-- dump date 20111121_010027 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762376000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 762376000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376000003 Walker A motif; other site 762376000004 ATP binding site [chemical binding]; other site 762376000005 Walker B motif; other site 762376000006 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762376000007 arginine finger; other site 762376000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762376000009 DnaA box-binding interface [nucleotide binding]; other site 762376000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 762376000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 762376000012 putative DNA binding surface [nucleotide binding]; other site 762376000013 dimer interface [polypeptide binding]; other site 762376000014 beta-clamp/clamp loader binding surface; other site 762376000015 beta-clamp/translesion DNA polymerase binding surface; other site 762376000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 762376000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376000018 ATP binding site [chemical binding]; other site 762376000019 Mg2+ binding site [ion binding]; other site 762376000020 G-X-G motif; other site 762376000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 762376000022 anchoring element; other site 762376000023 dimer interface [polypeptide binding]; other site 762376000024 ATP binding site [chemical binding]; other site 762376000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762376000026 active site 762376000027 putative metal-binding site [ion binding]; other site 762376000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762376000029 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376000030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000031 DNA-binding site [nucleotide binding]; DNA binding site 762376000032 FCD domain; Region: FCD; cl11656 762376000033 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762376000034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376000035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376000036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000037 substrate binding pocket [chemical binding]; other site 762376000038 membrane-bound complex binding site; other site 762376000039 hinge residues; other site 762376000040 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000042 dimer interface [polypeptide binding]; other site 762376000043 conserved gate region; other site 762376000044 putative PBP binding loops; other site 762376000045 ABC-ATPase subunit interface; other site 762376000046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376000047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000048 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376000049 Walker A/P-loop; other site 762376000050 ATP binding site [chemical binding]; other site 762376000051 Q-loop/lid; other site 762376000052 ABC transporter signature motif; other site 762376000053 Walker B; other site 762376000054 D-loop; other site 762376000055 H-loop/switch region; other site 762376000056 serine/threonine dehydratase; Validated; Region: PRK07048 762376000057 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376000058 tetramer interface [polypeptide binding]; other site 762376000059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000060 catalytic residue [active] 762376000061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376000062 aspartate aminotransferase; Provisional; Region: PRK08361 762376000063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000064 homodimer interface [polypeptide binding]; other site 762376000065 catalytic residue [active] 762376000066 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376000067 homotrimer interaction site [polypeptide binding]; other site 762376000068 putative active site [active] 762376000069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000071 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376000072 putative effector binding pocket; other site 762376000073 dimerization interface [polypeptide binding]; other site 762376000074 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 762376000075 Isochorismatase family; Region: Isochorismatase; pfam00857 762376000076 catalytic triad [active] 762376000077 dimer interface [polypeptide binding]; other site 762376000078 conserved cis-peptide bond; other site 762376000079 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 762376000080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000081 putative substrate translocation pore; other site 762376000082 Pirin-related protein [General function prediction only]; Region: COG1741 762376000083 Cupin domain; Region: Cupin_2; cl09118 762376000084 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 762376000085 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376000086 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376000087 active site 762376000088 DoxX; Region: DoxX; cl00976 762376000089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376000091 substrate binding pocket [chemical binding]; other site 762376000092 membrane-bound complex binding site; other site 762376000093 hinge residues; other site 762376000094 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000096 dimer interface [polypeptide binding]; other site 762376000097 conserved gate region; other site 762376000098 putative PBP binding loops; other site 762376000099 ABC-ATPase subunit interface; other site 762376000100 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000101 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376000102 Walker A/P-loop; other site 762376000103 ATP binding site [chemical binding]; other site 762376000104 Q-loop/lid; other site 762376000105 ABC transporter signature motif; other site 762376000106 Walker B; other site 762376000107 D-loop; other site 762376000108 H-loop/switch region; other site 762376000109 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376000110 Cupin domain; Region: Cupin_2; cl09118 762376000111 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376000112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000113 DNA-binding site [nucleotide binding]; DNA binding site 762376000114 FCD domain; Region: FCD; cl11656 762376000115 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 762376000116 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 762376000117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000118 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 762376000119 putative substrate binding pocket [chemical binding]; other site 762376000120 putative dimerization interface [polypeptide binding]; other site 762376000121 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 762376000122 dimer interface [polypeptide binding]; other site 762376000123 putative metal binding site [ion binding]; other site 762376000124 Flavin Reductases; Region: FlaRed; cl00801 762376000125 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376000126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000127 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376000128 putative dimerization interface [polypeptide binding]; other site 762376000129 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376000131 substrate binding pocket [chemical binding]; other site 762376000132 membrane-bound complex binding site; other site 762376000133 hinge residues; other site 762376000134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000136 dimer interface [polypeptide binding]; other site 762376000137 conserved gate region; other site 762376000138 putative PBP binding loops; other site 762376000139 ABC-ATPase subunit interface; other site 762376000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000141 dimer interface [polypeptide binding]; other site 762376000142 conserved gate region; other site 762376000143 putative PBP binding loops; other site 762376000144 ABC-ATPase subunit interface; other site 762376000145 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000146 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376000147 Walker A/P-loop; other site 762376000148 ATP binding site [chemical binding]; other site 762376000149 Q-loop/lid; other site 762376000150 ABC transporter signature motif; other site 762376000151 Walker B; other site 762376000152 D-loop; other site 762376000153 H-loop/switch region; other site 762376000154 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 762376000155 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762376000156 tetramer interface [polypeptide binding]; other site 762376000157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000158 catalytic residue [active] 762376000159 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 762376000160 Acylphosphatase; Region: Acylphosphatase; cl00551 762376000161 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376000162 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 762376000163 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 762376000164 active site 762376000165 substrate binding site [chemical binding]; other site 762376000166 FMN binding site [chemical binding]; other site 762376000167 putative catalytic residues [active] 762376000168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000169 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376000170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000171 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 762376000172 cytosine deaminase; Provisional; Region: PRK05985 762376000173 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 762376000174 active site 762376000175 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762376000176 TM-ABC transporter signature motif; other site 762376000177 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762376000178 TM-ABC transporter signature motif; other site 762376000179 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 762376000180 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 762376000181 Walker A/P-loop; other site 762376000182 ATP binding site [chemical binding]; other site 762376000183 Q-loop/lid; other site 762376000184 ABC transporter signature motif; other site 762376000185 Walker B; other site 762376000186 D-loop; other site 762376000187 H-loop/switch region; other site 762376000188 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 762376000189 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762376000190 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 762376000191 putative ligand binding site [chemical binding]; other site 762376000192 Abi-like protein; Region: Abi_2; cl01988 762376000193 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376000194 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376000195 active site residue [active] 762376000196 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 762376000197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000198 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762376000199 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 762376000200 NAD binding site [chemical binding]; other site 762376000201 putative active site [active] 762376000202 substrate binding site [chemical binding]; other site 762376000203 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376000204 Flavin Reductases; Region: FlaRed; cl00801 762376000205 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 762376000206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376000207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376000208 major facilitator superfamily transporter; Provisional; Region: PRK05122 762376000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000210 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 762376000211 SET domain; Region: SET; cl02566 762376000212 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 762376000213 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000215 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 762376000216 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376000217 PYR/PP interface [polypeptide binding]; other site 762376000218 dimer interface [polypeptide binding]; other site 762376000219 TPP binding site [chemical binding]; other site 762376000220 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376000221 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762376000222 TPP-binding site [chemical binding]; other site 762376000223 dimer interface [polypeptide binding]; other site 762376000224 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 762376000225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000226 NAD(P) binding site [chemical binding]; other site 762376000227 active site 762376000228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376000229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000230 dimer interface [polypeptide binding]; other site 762376000231 conserved gate region; other site 762376000232 putative PBP binding loops; other site 762376000233 ABC-ATPase subunit interface; other site 762376000234 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376000235 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376000236 Walker A/P-loop; other site 762376000237 ATP binding site [chemical binding]; other site 762376000238 Q-loop/lid; other site 762376000239 ABC transporter signature motif; other site 762376000240 Walker B; other site 762376000241 D-loop; other site 762376000242 H-loop/switch region; other site 762376000243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000244 DNA topoisomerase III; Validated; Region: PRK08173 762376000245 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376000246 active site 762376000247 putative interdomain interaction site [polypeptide binding]; other site 762376000248 putative metal-binding site [ion binding]; other site 762376000249 putative nucleotide binding site [chemical binding]; other site 762376000250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 762376000251 domain I; other site 762376000252 DNA binding groove [nucleotide binding] 762376000253 phosphate binding site [ion binding]; other site 762376000254 domain II; other site 762376000255 domain III; other site 762376000256 nucleotide binding site [chemical binding]; other site 762376000257 catalytic site [active] 762376000258 domain IV; other site 762376000259 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 762376000260 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 762376000261 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376000262 active site 762376000263 HIGH motif; other site 762376000264 nucleotide binding site [chemical binding]; other site 762376000265 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376000266 active site 762376000267 KMSKS motif; other site 762376000268 Protein of unknown function (DUF494); Region: DUF494; cl01103 762376000269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376000270 DctM-like transporters; Region: DctM; pfam06808 762376000271 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 762376000272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000273 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376000274 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 762376000275 dimer interface [polypeptide binding]; other site 762376000276 active site 762376000277 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376000278 substrate binding site [chemical binding]; other site 762376000279 catalytic residue [active] 762376000280 Entericidin EcnA/B family; Region: Entericidin; cl02322 762376000281 CsbD-like; Region: CsbD; cl01272 762376000282 hypothetical protein; Provisional; Region: PRK13560 762376000283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376000284 putative active site [active] 762376000285 heme pocket [chemical binding]; other site 762376000286 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376000287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376000288 DNA binding residues [nucleotide binding] 762376000289 dimerization interface [polypeptide binding]; other site 762376000290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000292 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 762376000293 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376000294 inhibitor-cofactor binding pocket; inhibition site 762376000295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000296 catalytic residue [active] 762376000297 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 762376000298 putative RNAase interaction site [polypeptide binding]; other site 762376000299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376000300 dimerization interface [polypeptide binding]; other site 762376000301 putative DNA binding site [nucleotide binding]; other site 762376000302 putative Zn2+ binding site [ion binding]; other site 762376000303 Fic/DOC family; Region: Fic; cl00960 762376000304 Restriction endonuclease; Region: Mrr_cat; cl00747 762376000305 maltose O-acetyltransferase; Provisional; Region: PRK10092 762376000306 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 762376000307 trimer interface [polypeptide binding]; other site 762376000308 active site 762376000309 substrate binding site [chemical binding]; other site 762376000310 CoA binding site [chemical binding]; other site 762376000311 haloalkane dehalogenase; Provisional; Region: PRK03592 762376000312 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 762376000313 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376000314 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 762376000315 Isochorismatase family; Region: Isochorismatase; pfam00857 762376000316 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376000317 catalytic triad [active] 762376000318 conserved cis-peptide bond; other site 762376000319 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 762376000320 agmatine deiminase; Region: agmatine_aguA; TIGR03380 762376000321 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376000322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000324 dimerization interface [polypeptide binding]; other site 762376000325 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376000326 classical (c) SDRs; Region: SDR_c; cd05233 762376000327 NAD(P) binding site [chemical binding]; other site 762376000328 active site 762376000329 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376000330 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376000331 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376000332 N-terminal plug; other site 762376000333 ligand-binding site [chemical binding]; other site 762376000334 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376000335 FecR protein; Region: FecR; pfam04773 762376000336 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376000337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376000338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376000339 DNA binding residues [nucleotide binding] 762376000340 enterobactin exporter EntS; Provisional; Region: PRK10489 762376000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000343 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376000344 putative dimerization interface [polypeptide binding]; other site 762376000345 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762376000346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376000347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000349 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376000350 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 762376000351 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376000352 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376000353 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376000354 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376000355 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376000356 carboxyltransferase (CT) interaction site; other site 762376000357 biotinylation site [posttranslational modification]; other site 762376000358 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376000359 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376000360 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376000361 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 762376000362 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376000363 dimer interface [polypeptide binding]; other site 762376000364 active site 762376000365 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 762376000366 isovaleryl-CoA dehydrogenase; Region: PLN02519 762376000367 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 762376000368 substrate binding site [chemical binding]; other site 762376000369 FAD binding site [chemical binding]; other site 762376000370 catalytic base [active] 762376000371 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376000372 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376000373 metal binding site [ion binding]; metal-binding site 762376000374 putative dimer interface [polypeptide binding]; other site 762376000375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000377 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 762376000378 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 762376000379 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762376000380 DNA binding residues [nucleotide binding] 762376000381 putative dimer interface [polypeptide binding]; other site 762376000382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376000383 LysE type translocator; Region: LysE; cl00565 762376000384 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136 762376000385 putative FMN binding site [chemical binding]; other site 762376000386 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762376000387 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376000388 homodimer interface [polypeptide binding]; other site 762376000389 substrate-cofactor binding pocket; other site 762376000390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000391 catalytic residue [active] 762376000392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376000393 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376000394 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376000395 putative ligand binding site [chemical binding]; other site 762376000396 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 762376000397 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762376000398 catalytic residues [active] 762376000399 hinge region; other site 762376000400 alpha helical domain; other site 762376000401 Sporulation related domain; Region: SPOR; cl10051 762376000402 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 762376000403 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 762376000404 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762376000405 active site 762376000406 HIGH motif; other site 762376000407 KMSK motif region; other site 762376000408 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762376000409 tRNA binding surface [nucleotide binding]; other site 762376000410 anticodon binding site; other site 762376000411 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 762376000412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000413 dimer interface [polypeptide binding]; other site 762376000414 conserved gate region; other site 762376000415 putative PBP binding loops; other site 762376000416 ABC-ATPase subunit interface; other site 762376000417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000418 dimer interface [polypeptide binding]; other site 762376000419 conserved gate region; other site 762376000420 putative PBP binding loops; other site 762376000421 ABC-ATPase subunit interface; other site 762376000422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376000423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000424 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762376000425 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 762376000426 Walker A/P-loop; other site 762376000427 ATP binding site [chemical binding]; other site 762376000428 Q-loop/lid; other site 762376000429 ABC transporter signature motif; other site 762376000430 Walker B; other site 762376000431 D-loop; other site 762376000432 H-loop/switch region; other site 762376000433 TOBE domain; Region: TOBE_2; cl01440 762376000434 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376000435 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 762376000436 active site 762376000437 metal binding site [ion binding]; metal-binding site 762376000438 hexamer interface [polypeptide binding]; other site 762376000439 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376000440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376000441 DNA binding site [nucleotide binding] 762376000442 domain linker motif; other site 762376000443 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 762376000444 putative dimerization interface [polypeptide binding]; other site 762376000445 putative ligand binding site [chemical binding]; other site 762376000446 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376000447 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376000448 2-isopropylmalate synthase; Validated; Region: PRK03739 762376000449 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 762376000450 active site 762376000451 catalytic residues [active] 762376000452 metal binding site [ion binding]; metal-binding site 762376000453 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 762376000454 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 762376000455 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 762376000456 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 762376000457 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 762376000458 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 762376000459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000461 dimerization interface [polypeptide binding]; other site 762376000462 EamA-like transporter family; Region: EamA; cl01037 762376000463 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 762376000464 Ferritin-like domain; Region: Ferritin; pfam00210 762376000465 heme binding site [chemical binding]; other site 762376000466 ferroxidase pore; other site 762376000467 ferroxidase diiron center [ion binding]; other site 762376000468 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 762376000469 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 762376000470 G1 box; other site 762376000471 putative GEF interaction site [polypeptide binding]; other site 762376000472 GTP/Mg2+ binding site [chemical binding]; other site 762376000473 Switch I region; other site 762376000474 G2 box; other site 762376000475 G3 box; other site 762376000476 Switch II region; other site 762376000477 G4 box; other site 762376000478 G5 box; other site 762376000479 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 762376000480 LysE type translocator; Region: LysE; cl00565 762376000481 helicase 45; Provisional; Region: PTZ00424 762376000482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762376000483 ATP binding site [chemical binding]; other site 762376000484 Mg++ binding site [ion binding]; other site 762376000485 motif III; other site 762376000486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376000487 nucleotide binding region [chemical binding]; other site 762376000488 ATP-binding site [chemical binding]; other site 762376000489 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 762376000490 hypothetical protein; Provisional; Region: PRK11367 762376000491 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762376000492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376000493 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 762376000494 active site 762376000495 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376000496 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376000497 Walker A/P-loop; other site 762376000498 ATP binding site [chemical binding]; other site 762376000499 Q-loop/lid; other site 762376000500 ABC transporter signature motif; other site 762376000501 Walker B; other site 762376000502 D-loop; other site 762376000503 H-loop/switch region; other site 762376000504 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376000505 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376000506 Walker A/P-loop; other site 762376000507 ATP binding site [chemical binding]; other site 762376000508 Q-loop/lid; other site 762376000509 ABC transporter signature motif; other site 762376000510 Walker B; other site 762376000511 D-loop; other site 762376000512 H-loop/switch region; other site 762376000513 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376000514 dipeptide transporter; Provisional; Region: PRK10913 762376000515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000516 dimer interface [polypeptide binding]; other site 762376000517 conserved gate region; other site 762376000518 putative PBP binding loops; other site 762376000519 ABC-ATPase subunit interface; other site 762376000520 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376000521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376000522 dimer interface [polypeptide binding]; other site 762376000523 conserved gate region; other site 762376000524 putative PBP binding loops; other site 762376000525 ABC-ATPase subunit interface; other site 762376000526 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376000527 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376000528 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 762376000529 G1 box; other site 762376000530 GTP/Mg2+ binding site [chemical binding]; other site 762376000531 Switch I region; other site 762376000532 G2 box; other site 762376000533 Switch II region; other site 762376000534 G3 box; other site 762376000535 G4 box; other site 762376000536 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 762376000537 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 762376000538 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376000539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000540 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 762376000541 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762376000542 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376000543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376000544 catalytic residue [active] 762376000545 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 762376000546 homotrimer interaction site [polypeptide binding]; other site 762376000547 putative active site [active] 762376000548 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376000549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000550 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376000551 dimerization interface [polypeptide binding]; other site 762376000552 substrate binding pocket [chemical binding]; other site 762376000553 Stringent starvation protein B; Region: SspB; cl01120 762376000554 stringent starvation protein A; Provisional; Region: sspA; PRK09481 762376000555 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 762376000556 C-terminal domain interface [polypeptide binding]; other site 762376000557 putative GSH binding site (G-site) [chemical binding]; other site 762376000558 dimer interface [polypeptide binding]; other site 762376000559 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 762376000560 dimer interface [polypeptide binding]; other site 762376000561 N-terminal domain interface [polypeptide binding]; other site 762376000562 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 762376000563 cytochrome b; Provisional; Region: CYTB; MTH00145 762376000564 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 762376000565 Qi binding site; other site 762376000566 intrachain domain interface; other site 762376000567 interchain domain interface [polypeptide binding]; other site 762376000568 heme bH binding site [chemical binding]; other site 762376000569 heme bL binding site [chemical binding]; other site 762376000570 Qo binding site; other site 762376000571 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 762376000572 interchain domain interface [polypeptide binding]; other site 762376000573 intrachain domain interface; other site 762376000574 Qi binding site; other site 762376000575 Qo binding site; other site 762376000576 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 762376000577 [2Fe-2S] cluster binding site [ion binding]; other site 762376000578 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 762376000579 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376000580 intersubunit interface [polypeptide binding]; other site 762376000581 active site 762376000582 Zn2+ binding site [ion binding]; other site 762376000583 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376000584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000585 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376000586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000587 putative substrate translocation pore; other site 762376000588 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376000589 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376000590 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 762376000591 dimer interface [polypeptide binding]; other site 762376000592 substrate binding pocket (H-site) [chemical binding]; other site 762376000593 N-terminal domain interface [polypeptide binding]; other site 762376000594 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762376000595 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 762376000596 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 762376000597 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762376000598 protein binding site [polypeptide binding]; other site 762376000599 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 762376000600 sec-independent translocase; Provisional; Region: tatB; PRK00404 762376000601 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 762376000602 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 762376000603 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 762376000604 nucleotide binding site/active site [active] 762376000605 HIT family signature motif; other site 762376000606 catalytic residue [active] 762376000607 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 762376000608 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 762376000609 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 762376000610 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 762376000611 substrate binding site [chemical binding]; other site 762376000612 glutamase interaction surface [polypeptide binding]; other site 762376000613 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 762376000614 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 762376000615 catalytic residues [active] 762376000616 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 762376000617 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762376000618 putative active site [active] 762376000619 oxyanion strand; other site 762376000620 catalytic triad [active] 762376000621 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762376000622 putative active site pocket [active] 762376000623 4-fold oligomerization interface [polypeptide binding]; other site 762376000624 metal binding residues [ion binding]; metal-binding site 762376000625 3-fold/trimer interface [polypeptide binding]; other site 762376000626 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 762376000627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376000628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000629 homodimer interface [polypeptide binding]; other site 762376000630 catalytic residue [active] 762376000631 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 762376000632 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 762376000633 NAD binding site [chemical binding]; other site 762376000634 dimerization interface [polypeptide binding]; other site 762376000635 product binding site; other site 762376000636 substrate binding site [chemical binding]; other site 762376000637 zinc binding site [ion binding]; other site 762376000638 catalytic residues [active] 762376000639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000640 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 762376000641 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762376000642 hinge; other site 762376000643 active site 762376000644 BolA-like protein; Region: BolA; cl00386 762376000645 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376000646 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 762376000647 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762376000648 Walker A/P-loop; other site 762376000649 ATP binding site [chemical binding]; other site 762376000650 Q-loop/lid; other site 762376000651 ABC transporter signature motif; other site 762376000652 Walker B; other site 762376000653 D-loop; other site 762376000654 H-loop/switch region; other site 762376000655 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 762376000656 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 762376000657 VacJ like lipoprotein; Region: VacJ; cl01073 762376000658 mce related protein; Region: MCE; cl03606 762376000659 Domain of unknown function DUF140; Region: DUF140; cl00510 762376000660 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762376000661 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 762376000662 Walker A/P-loop; other site 762376000663 ATP binding site [chemical binding]; other site 762376000664 Q-loop/lid; other site 762376000665 ABC transporter signature motif; other site 762376000666 Walker B; other site 762376000667 D-loop; other site 762376000668 H-loop/switch region; other site 762376000669 Nitronate monooxygenase; Region: NMO; pfam03060 762376000670 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376000671 FMN binding site [chemical binding]; other site 762376000672 substrate binding site [chemical binding]; other site 762376000673 putative catalytic residue [active] 762376000674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000676 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 762376000677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000679 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 762376000680 putative dimerization interface [polypeptide binding]; other site 762376000681 Surface antigen; Region: Surface_Ag_2; cl01155 762376000682 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 762376000683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376000684 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 762376000685 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 762376000686 active site 762376000687 dimer interface [polypeptide binding]; other site 762376000688 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 762376000689 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 762376000690 active site 762376000691 FMN binding site [chemical binding]; other site 762376000692 substrate binding site [chemical binding]; other site 762376000693 3Fe-4S cluster binding site [ion binding]; other site 762376000694 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 762376000695 domain interface; other site 762376000696 Predicted esterase [General function prediction only]; Region: COG0627 762376000697 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376000698 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 762376000699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376000700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376000701 DNA binding residues [nucleotide binding] 762376000702 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 762376000703 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376000704 active site 762376000705 metal binding site [ion binding]; metal-binding site 762376000706 hexamer interface [polypeptide binding]; other site 762376000707 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762376000708 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762376000709 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762376000710 nudix motif; other site 762376000711 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 762376000712 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 762376000713 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376000714 Cytochrome c [Energy production and conversion]; Region: COG3258 762376000715 Cytochrome c; Region: Cytochrom_C; cl11414 762376000716 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376000717 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 762376000718 Subunit I/III interface [polypeptide binding]; other site 762376000719 D-pathway; other site 762376000720 Subunit I/VIIc interface [polypeptide binding]; other site 762376000721 Subunit I/IV interface [polypeptide binding]; other site 762376000722 Subunit I/II interface [polypeptide binding]; other site 762376000723 Low-spin heme (heme a) binding site [chemical binding]; other site 762376000724 Subunit I/VIIa interface [polypeptide binding]; other site 762376000725 Subunit I/VIa interface [polypeptide binding]; other site 762376000726 Dimer interface; other site 762376000727 Putative water exit pathway; other site 762376000728 Binuclear center (heme a3/CuB) [ion binding]; other site 762376000729 K-pathway; other site 762376000730 Subunit I/Vb interface [polypeptide binding]; other site 762376000731 Putative proton exit pathway; other site 762376000732 Subunit I/VIb interface; other site 762376000733 Subunit I/VIc interface [polypeptide binding]; other site 762376000734 Electron transfer pathway; other site 762376000735 Subunit I/VIIIb interface [polypeptide binding]; other site 762376000736 Subunit I/VIIb interface [polypeptide binding]; other site 762376000737 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 762376000738 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 762376000739 Subunit III/VIIa interface [polypeptide binding]; other site 762376000740 Phospholipid binding site [chemical binding]; other site 762376000741 Subunit I/III interface [polypeptide binding]; other site 762376000742 Subunit III/VIb interface [polypeptide binding]; other site 762376000743 Subunit III/VIa interface; other site 762376000744 Subunit III/Vb interface [polypeptide binding]; other site 762376000745 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 762376000746 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762376000747 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376000748 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 762376000749 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 762376000750 UbiA prenyltransferase family; Region: UbiA; cl00337 762376000751 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376000752 Cu(I) binding site [ion binding]; other site 762376000753 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 762376000754 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 762376000755 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762376000756 Substrate binding site [chemical binding]; other site 762376000757 Mg++ binding site [ion binding]; other site 762376000758 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762376000759 active site 762376000760 substrate binding site [chemical binding]; other site 762376000761 CoA binding site [chemical binding]; other site 762376000762 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000764 putative substrate translocation pore; other site 762376000765 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 762376000766 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376000767 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 762376000768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376000769 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376000770 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000772 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762376000773 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 762376000774 glutaminase active site [active] 762376000775 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762376000776 dimer interface [polypeptide binding]; other site 762376000777 active site 762376000778 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762376000779 dimer interface [polypeptide binding]; other site 762376000780 active site 762376000781 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 762376000782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000783 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376000784 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 762376000785 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 762376000786 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 762376000787 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 762376000788 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762376000789 putative ADP-binding pocket [chemical binding]; other site 762376000790 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 762376000791 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762376000792 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376000793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376000794 Q-loop/lid; other site 762376000795 ABC transporter signature motif; other site 762376000796 Walker B; other site 762376000797 D-loop; other site 762376000798 H-loop/switch region; other site 762376000799 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 762376000800 Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178 762376000801 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 762376000802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376000803 TPR motif; other site 762376000804 binding surface 762376000805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376000806 putative acyl-acceptor binding pocket; other site 762376000807 Pectate lyase; Region: Pec_lyase_C; cl01593 762376000808 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376000809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000810 OsmC-like protein; Region: OsmC; cl00767 762376000811 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376000812 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376000813 ligand binding site [chemical binding]; other site 762376000814 flexible hinge region; other site 762376000815 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376000816 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376000817 putative ligand binding site [chemical binding]; other site 762376000818 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 762376000819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376000820 classical (c) SDRs; Region: SDR_c; cd05233 762376000821 NAD(P) binding site [chemical binding]; other site 762376000822 active site 762376000823 Integral membrane protein TerC family; Region: TerC; cl10468 762376000824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376000825 Ligand Binding Site [chemical binding]; other site 762376000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376000827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376000828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376000829 active site 762376000830 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376000831 Flavin Reductases; Region: FlaRed; cl00801 762376000832 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376000833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000835 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376000836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376000837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000838 NAD(P) binding site [chemical binding]; other site 762376000839 active site 762376000840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376000841 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376000842 active site 762376000843 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376000844 active site 2 [active] 762376000845 active site 1 [active] 762376000846 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 762376000847 active site 762376000848 oxalacetate binding site [chemical binding]; other site 762376000849 citrylCoA binding site [chemical binding]; other site 762376000850 coenzyme A binding site [chemical binding]; other site 762376000851 catalytic triad [active] 762376000852 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376000853 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376000854 CHAT domain; Region: CHAT; cl02083 762376000855 PAS fold; Region: PAS_4; pfam08448 762376000856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376000857 putative active site [active] 762376000858 heme pocket [chemical binding]; other site 762376000859 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 762376000860 active site 762376000861 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 762376000862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376000863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376000864 active site 762376000865 catalytic tetrad [active] 762376000866 transcriptional regulator; Provisional; Region: PRK10632 762376000867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000869 dimerization interface [polypeptide binding]; other site 762376000870 ornithine cyclodeaminase; Validated; Region: PRK06141 762376000871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000872 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 762376000873 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376000874 tetramer interface [polypeptide binding]; other site 762376000875 active site 762376000876 catalytic triad [active] 762376000877 dimer interface [polypeptide binding]; other site 762376000878 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376000880 ornithine cyclodeaminase; Validated; Region: PRK07589 762376000881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000882 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 762376000883 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 762376000884 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 762376000885 G1 box; other site 762376000886 GTP/Mg2+ binding site [chemical binding]; other site 762376000887 Switch I region; other site 762376000888 G2 box; other site 762376000889 Switch II region; other site 762376000890 G3 box; other site 762376000891 G4 box; other site 762376000892 G5 box; other site 762376000893 Domain of unknown function (DUF697); Region: DUF697; cl12064 762376000894 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 762376000895 oligomerization interface [polypeptide binding]; other site 762376000896 active site 762376000897 metal binding site [ion binding]; metal-binding site 762376000898 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 762376000899 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376000900 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 762376000901 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 762376000902 active site 762376000903 metal binding site [ion binding]; metal-binding site 762376000904 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376000905 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 762376000906 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 762376000907 substrate binding site [chemical binding]; other site 762376000908 catalytic Zn binding site [ion binding]; other site 762376000909 NAD binding site [chemical binding]; other site 762376000910 structural Zn binding site [ion binding]; other site 762376000911 dimer interface [polypeptide binding]; other site 762376000912 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 762376000913 putative metal binding site [ion binding]; other site 762376000914 putative homotetramer interface [polypeptide binding]; other site 762376000915 putative homodimer interface [polypeptide binding]; other site 762376000916 putative homodimer-homodimer interface [polypeptide binding]; other site 762376000917 putative allosteric switch controlling residues; other site 762376000918 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 762376000919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000920 DNA-binding site [nucleotide binding]; DNA binding site 762376000921 UTRA domain; Region: UTRA; cl06649 762376000922 HutD; Region: HutD; cl01532 762376000923 urocanate hydratase; Provisional; Region: PRK05414 762376000924 urocanate hydratase; Region: hutU; TIGR01228 762376000925 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 762376000926 Sodium:solute symporter family; Region: SSF; cl00456 762376000927 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376000928 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 762376000929 active sites [active] 762376000930 tetramer interface [polypeptide binding]; other site 762376000931 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762376000932 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 762376000933 active site 762376000934 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 762376000935 active site 762376000936 catalytic triad [active] 762376000937 dimer interface [polypeptide binding]; other site 762376000938 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376000939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000940 putative substrate translocation pore; other site 762376000941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000943 putative substrate translocation pore; other site 762376000944 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 762376000945 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 762376000946 sulfite oxidase; Provisional; Region: PLN00177 762376000947 Moco binding site; other site 762376000948 metal coordination site [ion binding]; other site 762376000949 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 762376000950 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 762376000951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376000952 catalytic loop [active] 762376000953 iron binding site [ion binding]; other site 762376000954 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 762376000955 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376000956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000957 DNA-binding site [nucleotide binding]; DNA binding site 762376000958 FCD domain; Region: FCD; cl11656 762376000959 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376000960 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376000961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376000962 NAD(P) binding site [chemical binding]; other site 762376000963 catalytic residues [active] 762376000964 Domain of unknown function (DUF336); Region: DUF336; cl01249 762376000965 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376000966 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376000967 catalytic loop [active] 762376000968 iron binding site [ion binding]; other site 762376000969 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 762376000970 FAD binding pocket [chemical binding]; other site 762376000971 FAD binding motif [chemical binding]; other site 762376000972 phosphate binding motif [ion binding]; other site 762376000973 beta-alpha-beta structure motif; other site 762376000974 NAD binding pocket [chemical binding]; other site 762376000975 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376000976 Ligand Binding Site [chemical binding]; other site 762376000977 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376000978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376000979 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376000980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376000981 Walker A/P-loop; other site 762376000982 ATP binding site [chemical binding]; other site 762376000983 Q-loop/lid; other site 762376000984 ABC transporter signature motif; other site 762376000985 Walker B; other site 762376000986 D-loop; other site 762376000987 H-loop/switch region; other site 762376000988 TOBE domain; Region: TOBE_2; cl01440 762376000989 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 762376000990 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 762376000991 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 762376000992 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376000993 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 762376000994 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 762376000995 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376000996 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 762376000997 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376000998 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376000999 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376001000 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376001001 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 762376001002 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 762376001003 molybdopterin cofactor binding site; other site 762376001004 Fe-S containing; Region: FDH-beta; TIGR01582 762376001005 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 762376001006 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 762376001007 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564; cl11689 762376001008 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 762376001009 selenocysteine synthase; Provisional; Region: PRK04311 762376001010 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 762376001011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376001012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376001013 catalytic residue [active] 762376001014 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 762376001015 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 762376001016 G1 box; other site 762376001017 putative GEF interaction site [polypeptide binding]; other site 762376001018 GTP/Mg2+ binding site [chemical binding]; other site 762376001019 Switch I region; other site 762376001020 G2 box; other site 762376001021 G3 box; other site 762376001022 Switch II region; other site 762376001023 G4 box; other site 762376001024 G5 box; other site 762376001025 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 762376001026 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 762376001027 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 762376001028 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 762376001029 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376001030 catalytic residues [active] 762376001031 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 762376001032 selenophosphate synthetase; Provisional; Region: PRK00943 762376001033 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 762376001034 dimerization interface [polypeptide binding]; other site 762376001035 putative ATP binding site [chemical binding]; other site 762376001036 Sulfatase; Region: Sulfatase; cl10460 762376001037 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 762376001038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001040 dimerization interface [polypeptide binding]; other site 762376001041 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 762376001042 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762376001043 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 762376001044 putative catalytic residue [active] 762376001045 Protein of unknown function (DUF779); Region: DUF779; cl01432 762376001046 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 762376001047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376001048 NAD(P) binding site [chemical binding]; other site 762376001049 catalytic residues [active] 762376001050 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 762376001051 GAF domain; Region: GAF; cl00853 762376001052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376001053 Walker A motif; other site 762376001054 ATP binding site [chemical binding]; other site 762376001055 Walker B motif; other site 762376001056 arginine finger; other site 762376001057 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376001058 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 762376001059 active site 762376001060 ribulose/triose binding site [chemical binding]; other site 762376001061 phosphate binding site [ion binding]; other site 762376001062 substrate (anthranilate) binding pocket [chemical binding]; other site 762376001063 product (indole) binding pocket [chemical binding]; other site 762376001064 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 762376001065 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762376001066 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762376001067 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 762376001068 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 762376001069 glutamine binding [chemical binding]; other site 762376001070 catalytic triad [active] 762376001071 anthranilate synthase component I; Provisional; Region: PRK13565 762376001072 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762376001073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762376001074 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376001075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376001076 motif II; other site 762376001077 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 762376001078 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 762376001079 substrate binding site [chemical binding]; other site 762376001080 hexamer interface [polypeptide binding]; other site 762376001081 metal binding site [ion binding]; metal-binding site 762376001082 Protein of unknown function (DUF525); Region: DUF525; cl01119 762376001083 MltA specific insert domain; Region: MltA; pfam03562 762376001084 3D domain; Region: 3D; cl01439 762376001085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376001086 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 762376001087 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 762376001088 dimerization domain [polypeptide binding]; other site 762376001089 dimer interface [polypeptide binding]; other site 762376001090 catalytic residues [active] 762376001091 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376001092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001093 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 762376001094 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 762376001095 Ligand Binding Site [chemical binding]; other site 762376001096 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 762376001097 active site 762376001098 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 762376001099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376001100 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376001101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001105 dimerization interface [polypeptide binding]; other site 762376001106 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001107 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 762376001108 putative ligand binding site [chemical binding]; other site 762376001109 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001110 TM-ABC transporter signature motif; other site 762376001111 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001112 TM-ABC transporter signature motif; other site 762376001113 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 762376001114 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376001115 Walker A/P-loop; other site 762376001116 ATP binding site [chemical binding]; other site 762376001117 Q-loop/lid; other site 762376001118 ABC transporter signature motif; other site 762376001119 Walker B; other site 762376001120 D-loop; other site 762376001121 H-loop/switch region; other site 762376001122 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 762376001123 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376001124 Walker A/P-loop; other site 762376001125 ATP binding site [chemical binding]; other site 762376001126 Q-loop/lid; other site 762376001127 ABC transporter signature motif; other site 762376001128 Walker B; other site 762376001129 D-loop; other site 762376001130 H-loop/switch region; other site 762376001131 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 762376001132 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376001133 multimer interface [polypeptide binding]; other site 762376001134 active site 762376001135 catalytic triad [active] 762376001136 dimer interface [polypeptide binding]; other site 762376001137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376001138 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 762376001139 Walker A motif; other site 762376001140 ATP binding site [chemical binding]; other site 762376001141 Walker B motif; other site 762376001142 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 762376001143 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 762376001144 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762376001145 metal ion-dependent adhesion site (MIDAS); other site 762376001146 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001147 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 762376001148 ligand binding site [chemical binding]; other site 762376001149 regulator interaction site; other site 762376001150 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376001151 ANTAR domain; Region: ANTAR; pfam03861 762376001152 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376001153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001154 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376001155 dimerization interface [polypeptide binding]; other site 762376001156 substrate binding pocket [chemical binding]; other site 762376001157 Transposase, Mutator family; Region: Transposase_mut; pfam00872 762376001158 MULE transposase domain; Region: MULE; pfam10551 762376001159 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 762376001160 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 762376001161 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 762376001162 protein binding site [polypeptide binding]; other site 762376001163 enoyl-CoA hydratase; Provisional; Region: PRK05862 762376001164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376001165 substrate binding site [chemical binding]; other site 762376001166 oxyanion hole (OAH) forming residues; other site 762376001167 trimer interface [polypeptide binding]; other site 762376001168 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376001169 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 762376001170 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376001171 ATP synthase A chain; Region: ATP-synt_A; cl00413 762376001172 ATP synthase subunit C; Region: ATP-synt_C; cl00466 762376001173 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 762376001174 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762376001175 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 762376001176 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762376001177 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762376001178 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762376001179 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762376001180 beta subunit interaction interface [polypeptide binding]; other site 762376001181 Walker A motif; other site 762376001182 ATP binding site [chemical binding]; other site 762376001183 Walker B motif; other site 762376001184 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762376001185 ATP synthase; Region: ATP-synt; cl00365 762376001186 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762376001187 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762376001188 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762376001189 alpha subunit interaction interface [polypeptide binding]; other site 762376001190 Walker A motif; other site 762376001191 ATP binding site [chemical binding]; other site 762376001192 Walker B motif; other site 762376001193 inhibitor binding site; inhibition site 762376001194 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762376001195 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 762376001196 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376001197 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 762376001198 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 762376001199 substrate binding site [chemical binding]; other site 762376001200 active site 762376001201 primosome assembly protein PriA; Validated; Region: PRK05580 762376001202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376001203 ATP binding site [chemical binding]; other site 762376001204 putative Mg++ binding site [ion binding]; other site 762376001205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 762376001206 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 762376001207 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376001208 TIGR03442 family protein; Region: TIGR03442 762376001209 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 762376001210 putative active site [active] 762376001211 putative dimer interface [polypeptide binding]; other site 762376001212 Replication initiator protein A; Region: RPA; cl02339 762376001213 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 762376001214 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 762376001215 putative trimer interface [polypeptide binding]; other site 762376001216 putative CoA binding site [chemical binding]; other site 762376001217 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376001218 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 762376001219 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 762376001220 metal binding site [ion binding]; metal-binding site 762376001221 dimer interface [polypeptide binding]; other site 762376001222 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 762376001223 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001224 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 762376001225 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376001226 Walker A/P-loop; other site 762376001227 ATP binding site [chemical binding]; other site 762376001228 Q-loop/lid; other site 762376001229 ABC transporter signature motif; other site 762376001230 Walker B; other site 762376001231 D-loop; other site 762376001232 H-loop/switch region; other site 762376001233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376001234 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376001235 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376001236 Walker A/P-loop; other site 762376001237 ATP binding site [chemical binding]; other site 762376001238 Q-loop/lid; other site 762376001239 ABC transporter signature motif; other site 762376001240 Walker B; other site 762376001241 D-loop; other site 762376001242 H-loop/switch region; other site 762376001243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376001244 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376001246 dimer interface [polypeptide binding]; other site 762376001247 conserved gate region; other site 762376001248 putative PBP binding loops; other site 762376001249 ABC-ATPase subunit interface; other site 762376001250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376001251 dimer interface [polypeptide binding]; other site 762376001252 conserved gate region; other site 762376001253 putative PBP binding loops; other site 762376001254 ABC-ATPase subunit interface; other site 762376001255 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376001256 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376001257 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 762376001258 active site 762376001259 Zn-binding site [ion binding]; other site 762376001260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001261 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376001262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001263 dimerization interface [polypeptide binding]; other site 762376001264 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376001265 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376001266 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762376001267 putative ATP binding site [chemical binding]; other site 762376001268 putative substrate binding site [chemical binding]; other site 762376001269 enoyl-CoA hydratase; Provisional; Region: PRK07327 762376001270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376001271 substrate binding site [chemical binding]; other site 762376001272 oxyanion hole (OAH) forming residues; other site 762376001273 trimer interface [polypeptide binding]; other site 762376001274 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376001275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376001276 substrate binding site [chemical binding]; other site 762376001277 oxyanion hole (OAH) forming residues; other site 762376001278 trimer interface [polypeptide binding]; other site 762376001279 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376001280 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376001281 FMN binding site [chemical binding]; other site 762376001282 substrate binding site [chemical binding]; other site 762376001283 putative catalytic residue [active] 762376001284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376001285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376001286 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376001287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376001288 active site 762376001289 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376001290 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 762376001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376001293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001296 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 762376001297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376001298 active site 762376001299 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376001300 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376001301 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 762376001302 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376001303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001304 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001308 dimerization interface [polypeptide binding]; other site 762376001309 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 762376001310 classical (c) SDRs; Region: SDR_c; cd05233 762376001311 NAD(P) binding site [chemical binding]; other site 762376001312 active site 762376001313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001315 NAD(P) binding site [chemical binding]; other site 762376001316 active site 762376001317 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376001318 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376001319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001321 Cytochrome c; Region: Cytochrom_C; cl11414 762376001322 Cytochrome c; Region: Cytochrom_C; cl11414 762376001323 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376001324 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001325 N-terminal plug; other site 762376001326 ligand-binding site [chemical binding]; other site 762376001327 fec operon regulator FecR; Reviewed; Region: PRK09774 762376001328 FecR protein; Region: FecR; pfam04773 762376001329 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376001330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376001331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376001332 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376001333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001334 DNA-binding site [nucleotide binding]; DNA binding site 762376001335 UTRA domain; Region: UTRA; cl06649 762376001336 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 762376001337 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762376001338 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762376001339 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 762376001340 ligand binding site [chemical binding]; other site 762376001341 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 762376001342 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 762376001343 Walker A/P-loop; other site 762376001344 ATP binding site [chemical binding]; other site 762376001345 Q-loop/lid; other site 762376001346 ABC transporter signature motif; other site 762376001347 Walker B; other site 762376001348 D-loop; other site 762376001349 H-loop/switch region; other site 762376001350 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 762376001351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762376001352 TM-ABC transporter signature motif; other site 762376001353 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376001354 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376001355 active site 762376001356 catalytic tetrad [active] 762376001357 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 762376001358 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 762376001359 putative active site; other site 762376001360 catalytic residue [active] 762376001361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376001362 catalytic loop [active] 762376001363 iron binding site [ion binding]; other site 762376001364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376001365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376001366 dimer interface [polypeptide binding]; other site 762376001367 phosphorylation site [posttranslational modification] 762376001368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001369 ATP binding site [chemical binding]; other site 762376001370 Mg2+ binding site [ion binding]; other site 762376001371 G-X-G motif; other site 762376001372 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762376001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376001374 active site 762376001375 phosphorylation site [posttranslational modification] 762376001376 intermolecular recognition site; other site 762376001377 dimerization interface [polypeptide binding]; other site 762376001378 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376001379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376001380 active site 762376001381 phosphorylation site [posttranslational modification] 762376001382 intermolecular recognition site; other site 762376001383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376001384 DNA binding residues [nucleotide binding] 762376001385 dimerization interface [polypeptide binding]; other site 762376001386 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 762376001387 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 762376001388 putative active site [active] 762376001389 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376001390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376001391 Walker A/P-loop; other site 762376001392 ATP binding site [chemical binding]; other site 762376001393 Q-loop/lid; other site 762376001394 ABC transporter signature motif; other site 762376001395 Walker B; other site 762376001396 D-loop; other site 762376001397 H-loop/switch region; other site 762376001398 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 762376001399 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376001400 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 762376001401 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 762376001402 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 762376001403 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 762376001404 putative DNA binding site [nucleotide binding]; other site 762376001405 putative homodimer interface [polypeptide binding]; other site 762376001406 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 762376001407 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 762376001408 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 762376001409 active site 762376001410 DNA binding site [nucleotide binding] 762376001411 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 762376001412 DNA binding site [nucleotide binding] 762376001413 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862 762376001414 nucleotide binding site [chemical binding]; other site 762376001415 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376001416 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762376001417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001418 NAD(P) binding site [chemical binding]; other site 762376001419 active site 762376001420 OsmC-like protein; Region: OsmC; cl00767 762376001421 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001423 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376001424 putative effector binding pocket; other site 762376001425 dimerization interface [polypeptide binding]; other site 762376001426 Cupin domain; Region: Cupin_2; cl09118 762376001427 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 762376001428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376001429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376001430 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 762376001431 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376001433 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001435 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376001436 short chain dehydrogenase; Provisional; Region: PRK12939 762376001437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001438 NAD(P) binding site [chemical binding]; other site 762376001439 active site 762376001440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376001442 dimerization interface [polypeptide binding]; other site 762376001443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001445 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 762376001446 Cupin domain; Region: Cupin_2; cl09118 762376001447 Cupin domain; Region: Cupin_2; cl09118 762376001448 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376001449 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376001450 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001451 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376001452 putative ligand binding site [chemical binding]; other site 762376001453 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001454 TM-ABC transporter signature motif; other site 762376001455 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001456 TM-ABC transporter signature motif; other site 762376001457 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001458 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376001459 Walker A/P-loop; other site 762376001460 ATP binding site [chemical binding]; other site 762376001461 Q-loop/lid; other site 762376001462 ABC transporter signature motif; other site 762376001463 Walker B; other site 762376001464 D-loop; other site 762376001465 H-loop/switch region; other site 762376001466 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001467 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376001468 Walker A/P-loop; other site 762376001469 ATP binding site [chemical binding]; other site 762376001470 Q-loop/lid; other site 762376001471 ABC transporter signature motif; other site 762376001472 Walker B; other site 762376001473 D-loop; other site 762376001474 H-loop/switch region; other site 762376001475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001477 DNA-binding site [nucleotide binding]; DNA binding site 762376001478 FCD domain; Region: FCD; cl11656 762376001479 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762376001480 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001481 substrate binding pocket [chemical binding]; other site 762376001482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376001484 dimerization interface [polypeptide binding]; other site 762376001485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001487 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 762376001488 active site 762376001489 Zn-binding site [ion binding]; other site 762376001490 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 762376001491 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 762376001492 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 762376001493 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001494 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376001496 DNA binding residues [nucleotide binding] 762376001497 Membrane transport protein; Region: Mem_trans; cl09117 762376001498 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376001499 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376001500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001503 SAF domain; Region: SAF; cl00555 762376001504 galactarate dehydratase; Region: galactar-dH20; TIGR03248 762376001505 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376001506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001507 DNA-binding site [nucleotide binding]; DNA binding site 762376001508 UTRA domain; Region: UTRA; cl06649 762376001509 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376001510 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 762376001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376001512 muropeptide transporter; Reviewed; Region: ampG; PRK11902 762376001513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 762376001514 universal stress protein UspE; Provisional; Region: PRK11175 762376001515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376001516 Ligand Binding Site [chemical binding]; other site 762376001517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376001518 Ligand Binding Site [chemical binding]; other site 762376001519 Predicted membrane protein [Function unknown]; Region: COG2860 762376001520 UPF0126 domain; Region: UPF0126; pfam03458 762376001521 UPF0126 domain; Region: UPF0126; pfam03458 762376001522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001524 DNA-binding site [nucleotide binding]; DNA binding site 762376001525 FCD domain; Region: FCD; cl11656 762376001526 LamB/YcsF family; Region: LamB_YcsF; cl00664 762376001527 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 762376001528 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 762376001529 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 762376001530 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 762376001531 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 762376001532 putative metal binding site [ion binding]; other site 762376001533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001534 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376001535 putative dimerization interface [polypeptide binding]; other site 762376001536 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376001537 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376001538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001539 N-terminal plug; other site 762376001540 ligand-binding site [chemical binding]; other site 762376001541 fec operon regulator FecR; Reviewed; Region: PRK09774 762376001542 FecR protein; Region: FecR; pfam04773 762376001543 RNA polymerase sigma factor; Reviewed; Region: PRK12523 762376001544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376001545 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 762376001546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001547 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 762376001548 L-serine binding site [chemical binding]; other site 762376001549 ACT domain interface; other site 762376001550 Protein of unknown function, DUF; Region: DUF411; cl01142 762376001551 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376001552 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376001553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376001554 dimer interface [polypeptide binding]; other site 762376001555 phosphorylation site [posttranslational modification] 762376001556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001557 ATP binding site [chemical binding]; other site 762376001558 Mg2+ binding site [ion binding]; other site 762376001559 G-X-G motif; other site 762376001560 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376001561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376001562 active site 762376001563 phosphorylation site [posttranslational modification] 762376001564 intermolecular recognition site; other site 762376001565 dimerization interface [polypeptide binding]; other site 762376001566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376001567 DNA binding site [nucleotide binding] 762376001568 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762376001569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376001570 dimer interface [polypeptide binding]; other site 762376001571 phosphorylation site [posttranslational modification] 762376001572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001573 ATP binding site [chemical binding]; other site 762376001574 Mg2+ binding site [ion binding]; other site 762376001575 G-X-G motif; other site 762376001576 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 762376001577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376001578 active site 762376001579 phosphorylation site [posttranslational modification] 762376001580 intermolecular recognition site; other site 762376001581 dimerization interface [polypeptide binding]; other site 762376001582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376001583 DNA binding site [nucleotide binding] 762376001584 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 762376001585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376001586 S-adenosylmethionine binding site [chemical binding]; other site 762376001587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376001588 Tim44-like domain; Region: Tim44; cl09208 762376001589 SCP-2 sterol transfer family; Region: SCP2; cl01225 762376001590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376001591 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 762376001592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376001593 active site 762376001594 nucleotide binding site [chemical binding]; other site 762376001595 HIGH motif; other site 762376001596 KMSKS motif; other site 762376001597 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 762376001598 Outer membrane efflux protein; Region: OEP; pfam02321 762376001599 Outer membrane efflux protein; Region: OEP; pfam02321 762376001600 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 762376001601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376001602 S-adenosylmethionine binding site [chemical binding]; other site 762376001603 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 762376001604 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762376001605 dimer interface [polypeptide binding]; other site 762376001606 substrate binding site [chemical binding]; other site 762376001607 ATP binding site [chemical binding]; other site 762376001608 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 762376001609 ThiS interaction site; other site 762376001610 putative active site [active] 762376001611 tetramer interface [polypeptide binding]; other site 762376001612 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 762376001613 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 762376001614 cobalamin binding residues [chemical binding]; other site 762376001615 putative BtuC binding residues; other site 762376001616 dimer interface [polypeptide binding]; other site 762376001617 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 762376001618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001619 N-terminal plug; other site 762376001620 ligand-binding site [chemical binding]; other site 762376001621 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 762376001622 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 762376001623 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 762376001624 substrate binding pocket [chemical binding]; other site 762376001625 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 762376001626 B12 binding site [chemical binding]; other site 762376001627 cobalt ligand [ion binding]; other site 762376001628 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 762376001629 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 762376001630 active site 762376001631 oxalacetate binding site [chemical binding]; other site 762376001632 citrylCoA binding site [chemical binding]; other site 762376001633 coenzyme A binding site [chemical binding]; other site 762376001634 catalytic triad [active] 762376001635 acyl-CoA synthetase; Validated; Region: PRK06188 762376001636 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376001637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001639 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376001640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001641 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 762376001642 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 762376001643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376001644 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376001645 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 762376001646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001649 dimerization interface [polypeptide binding]; other site 762376001650 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 762376001651 putative glutathione S-transferase; Provisional; Region: PRK10357 762376001652 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376001653 putative C-terminal domain interface [polypeptide binding]; other site 762376001654 putative GSH binding site (G-site) [chemical binding]; other site 762376001655 putative dimer interface [polypeptide binding]; other site 762376001656 GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205 762376001657 putative N-terminal domain interface [polypeptide binding]; other site 762376001658 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 762376001659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376001660 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001661 classical (c) SDRs; Region: SDR_c; cd05233 762376001662 NAD(P) binding site [chemical binding]; other site 762376001663 active site 762376001664 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001666 NAD(P) binding site [chemical binding]; other site 762376001667 active site 762376001668 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001669 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376001670 Walker A/P-loop; other site 762376001671 ATP binding site [chemical binding]; other site 762376001672 Q-loop/lid; other site 762376001673 ABC transporter signature motif; other site 762376001674 Walker B; other site 762376001675 D-loop; other site 762376001676 H-loop/switch region; other site 762376001677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001678 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376001679 Walker A/P-loop; other site 762376001680 ATP binding site [chemical binding]; other site 762376001681 Q-loop/lid; other site 762376001682 ABC transporter signature motif; other site 762376001683 Walker B; other site 762376001684 D-loop; other site 762376001685 H-loop/switch region; other site 762376001686 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001687 TM-ABC transporter signature motif; other site 762376001688 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001689 TM-ABC transporter signature motif; other site 762376001690 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001691 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376001692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376001693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001694 NAD(P) binding site [chemical binding]; other site 762376001695 active site 762376001696 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001698 DNA-binding site [nucleotide binding]; DNA binding site 762376001699 FCD domain; Region: FCD; cl11656 762376001700 classical (c) SDRs; Region: SDR_c; cd05233 762376001701 NAD(P) binding site [chemical binding]; other site 762376001702 active site 762376001703 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 762376001704 active site clefts [active] 762376001705 zinc binding site [ion binding]; other site 762376001706 dimer interface [polypeptide binding]; other site 762376001707 hypothetical protein; Provisional; Region: PRK11505 762376001708 psiF repeat; Region: PsiF_repeat; pfam07769 762376001709 indole acetimide hydrolase; Validated; Region: PRK07488 762376001710 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376001711 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 762376001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376001713 S-adenosylmethionine binding site [chemical binding]; other site 762376001714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376001715 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001717 DNA-binding site [nucleotide binding]; DNA binding site 762376001718 FCD domain; Region: FCD; cl11656 762376001719 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 762376001720 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376001721 PYR/PP interface [polypeptide binding]; other site 762376001722 dimer interface [polypeptide binding]; other site 762376001723 TPP binding site [chemical binding]; other site 762376001724 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376001725 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376001726 TPP-binding site [chemical binding]; other site 762376001727 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 762376001728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001729 NAD(P) binding site [chemical binding]; other site 762376001730 active site 762376001731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001733 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762376001734 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376001735 minor groove reading motif; other site 762376001736 helix-hairpin-helix signature motif; other site 762376001737 substrate binding pocket [chemical binding]; other site 762376001738 active site 762376001739 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 762376001740 DNA binding and oxoG recognition site [nucleotide binding] 762376001741 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 762376001742 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376001743 dimer interface [polypeptide binding]; other site 762376001744 PYR/PP interface [polypeptide binding]; other site 762376001745 TPP binding site [chemical binding]; other site 762376001746 substrate binding site [chemical binding]; other site 762376001747 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 762376001748 TPP-binding site; other site 762376001749 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 762376001750 glycerol kinase; Provisional; Region: glpK; PRK00047 762376001751 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762376001752 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 762376001753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376001754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376001755 putative substrate translocation pore; other site 762376001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376001757 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 762376001758 ScpA/B protein; Region: ScpA_ScpB; cl00598 762376001759 Pantoate-beta-alanine ligase; Region: PanC; cd00560 762376001760 pantoate--beta-alanine ligase; Region: panC; TIGR00018 762376001761 active site 762376001762 ATP-binding site [chemical binding]; other site 762376001763 pantoate-binding site; other site 762376001764 HXXH motif; other site 762376001765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376001766 DNA binding residues [nucleotide binding] 762376001767 dimerization interface [polypeptide binding]; other site 762376001768 Uncharacterized lipoprotein NlpE involved in copper resistance; Region: NlpE; cl01138 762376001769 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 762376001770 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 762376001771 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762376001772 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762376001773 CoA-binding site [chemical binding]; other site 762376001774 ATP-binding [chemical binding]; other site 762376001775 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 762376001776 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 762376001777 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 762376001778 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 762376001779 Protein export membrane protein; Region: SecD_SecF; cl14618 762376001780 NodT family; Region: outer_NodT; TIGR01845 762376001781 Outer membrane efflux protein; Region: OEP; pfam02321 762376001782 short chain dehydrogenase; Provisional; Region: PRK12744 762376001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001784 NAD(P) binding site [chemical binding]; other site 762376001785 active site 762376001786 transcriptional regulator; Provisional; Region: PRK10632 762376001787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001788 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376001789 putative effector binding pocket; other site 762376001790 putative dimerization interface [polypeptide binding]; other site 762376001791 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376001792 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376001793 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001794 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 762376001795 putative ligand binding site [chemical binding]; other site 762376001796 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376001797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001798 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376001799 putative dimerization interface [polypeptide binding]; other site 762376001800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001801 TM-ABC transporter signature motif; other site 762376001802 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001803 TM-ABC transporter signature motif; other site 762376001804 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001805 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376001806 Walker A/P-loop; other site 762376001807 ATP binding site [chemical binding]; other site 762376001808 Q-loop/lid; other site 762376001809 ABC transporter signature motif; other site 762376001810 Walker B; other site 762376001811 D-loop; other site 762376001812 H-loop/switch region; other site 762376001813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001814 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376001815 Walker A/P-loop; other site 762376001816 ATP binding site [chemical binding]; other site 762376001817 Q-loop/lid; other site 762376001818 ABC transporter signature motif; other site 762376001819 Walker B; other site 762376001820 D-loop; other site 762376001821 H-loop/switch region; other site 762376001822 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 762376001823 hypothetical protein; Provisional; Region: PRK08999 762376001824 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 762376001825 active site 762376001826 8-oxo-dGMP binding site [chemical binding]; other site 762376001827 nudix motif; other site 762376001828 metal binding site [ion binding]; metal-binding site 762376001829 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 762376001830 active site 762376001831 thiamine phosphate binding site [chemical binding]; other site 762376001832 pyrophosphate binding site [ion binding]; other site 762376001833 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 762376001834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376001835 Walker A motif; other site 762376001836 ATP binding site [chemical binding]; other site 762376001837 Walker B motif; other site 762376001838 arginine finger; other site 762376001839 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 762376001840 heterotetramer interface [polypeptide binding]; other site 762376001841 active site pocket [active] 762376001842 cleavage site 762376001843 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376001844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376001845 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001846 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376001847 putative ligand binding site [chemical binding]; other site 762376001848 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001849 TM-ABC transporter signature motif; other site 762376001850 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001851 TM-ABC transporter signature motif; other site 762376001852 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001853 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376001854 Walker A/P-loop; other site 762376001855 ATP binding site [chemical binding]; other site 762376001856 Q-loop/lid; other site 762376001857 ABC transporter signature motif; other site 762376001858 Walker B; other site 762376001859 D-loop; other site 762376001860 H-loop/switch region; other site 762376001861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001862 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376001863 Walker A/P-loop; other site 762376001864 ATP binding site [chemical binding]; other site 762376001865 Q-loop/lid; other site 762376001866 ABC transporter signature motif; other site 762376001867 Walker B; other site 762376001868 D-loop; other site 762376001869 H-loop/switch region; other site 762376001870 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 762376001871 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376001872 dimerization interface [polypeptide binding]; other site 762376001873 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 762376001874 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 762376001875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376001876 metal binding site [ion binding]; metal-binding site 762376001877 active site 762376001878 I-site; other site 762376001879 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 762376001880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376001881 PAS fold; Region: PAS_4; pfam08448 762376001882 putative active site [active] 762376001883 heme pocket [chemical binding]; other site 762376001884 GAF domain; Region: GAF; cl00853 762376001885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376001886 metal binding site [ion binding]; metal-binding site 762376001887 active site 762376001888 I-site; other site 762376001889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376001890 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 762376001891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376001892 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376001893 active site 762376001894 FMN binding site [chemical binding]; other site 762376001895 substrate binding site [chemical binding]; other site 762376001896 homotetramer interface [polypeptide binding]; other site 762376001897 catalytic residue [active] 762376001898 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001899 classical (c) SDRs; Region: SDR_c; cd05233 762376001900 NAD(P) binding site [chemical binding]; other site 762376001901 active site 762376001902 enoyl-CoA hydratase; Provisional; Region: PRK08258 762376001903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376001904 substrate binding site [chemical binding]; other site 762376001905 oxyanion hole (OAH) forming residues; other site 762376001906 trimer interface [polypeptide binding]; other site 762376001907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376001908 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376001909 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376001910 active site 762376001911 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376001912 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376001913 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376001914 active site 762376001915 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376001916 homotrimer interaction site [polypeptide binding]; other site 762376001917 putative active site [active] 762376001918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376001919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376001920 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376001921 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376001922 putative ligand binding site [chemical binding]; other site 762376001923 Dienelactone hydrolase family; Region: DLH; pfam01738 762376001924 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376001925 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376001926 iron-sulfur cluster [ion binding]; other site 762376001927 [2Fe-2S] cluster binding site [ion binding]; other site 762376001928 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 762376001929 putative alpha subunit interface [polypeptide binding]; other site 762376001930 putative active site [active] 762376001931 putative substrate binding site [chemical binding]; other site 762376001932 Fe binding site [ion binding]; other site 762376001933 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376001934 inter-subunit interface; other site 762376001935 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376001936 catalytic triad [active] 762376001937 conserved cis-peptide bond; other site 762376001938 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376001939 classical (c) SDRs; Region: SDR_c; cd05233 762376001940 NAD(P) binding site [chemical binding]; other site 762376001941 active site 762376001942 Protein of unknown function (DUF342); Region: DUF342; pfam03961 762376001943 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376001944 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376001945 catalytic residue [active] 762376001946 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 762376001947 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376001948 inhibitor-cofactor binding pocket; inhibition site 762376001949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376001950 catalytic residue [active] 762376001951 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 762376001952 thiamine phosphate binding site [chemical binding]; other site 762376001953 active site 762376001954 pyrophosphate binding site [ion binding]; other site 762376001955 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 762376001956 substrate binding site [chemical binding]; other site 762376001957 ATP binding site [chemical binding]; other site 762376001958 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 762376001959 Rubredoxin; Region: Rubredoxin; pfam00301 762376001960 iron binding site [ion binding]; other site 762376001961 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 762376001962 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 762376001963 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376001964 dihydroorotase; Provisional; Region: PRK07627 762376001965 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376001966 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 762376001967 active site 762376001968 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376001969 putative acyl-acceptor binding pocket; other site 762376001970 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 762376001971 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 762376001972 active site 762376001973 metal binding site [ion binding]; metal-binding site 762376001974 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 762376001975 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762376001976 Transglycosylase; Region: Transgly; cl07896 762376001977 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762376001978 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376001979 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376001980 shikimate binding site; other site 762376001981 NAD(P) binding site [chemical binding]; other site 762376001982 Gram-negative bacterial tonB protein; Region: TonB; cl10048 762376001983 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376001984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376001985 Walker A/P-loop; other site 762376001986 ATP binding site [chemical binding]; other site 762376001987 Q-loop/lid; other site 762376001988 ABC transporter signature motif; other site 762376001989 Walker B; other site 762376001990 D-loop; other site 762376001991 H-loop/switch region; other site 762376001992 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376001994 dimer interface [polypeptide binding]; other site 762376001995 conserved gate region; other site 762376001996 ABC-ATPase subunit interface; other site 762376001997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376001998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001999 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376002000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376002001 dimer interface [polypeptide binding]; other site 762376002002 phosphorylation site [posttranslational modification] 762376002003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376002004 ATP binding site [chemical binding]; other site 762376002005 Mg2+ binding site [ion binding]; other site 762376002006 G-X-G motif; other site 762376002007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376002009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376002010 active site 762376002011 phosphorylation site [posttranslational modification] 762376002012 intermolecular recognition site; other site 762376002013 dimerization interface [polypeptide binding]; other site 762376002014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376002015 DNA binding site [nucleotide binding] 762376002016 RNB domain; Region: RNB; pfam00773 762376002017 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 762376002018 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376002019 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 762376002020 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002021 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002022 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002023 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376002024 catalytic residues [active] 762376002025 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762376002026 trimer interface [polypeptide binding]; other site 762376002027 active site 762376002028 dimer interface [polypeptide binding]; other site 762376002029 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762376002030 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376002031 carboxyltransferase (CT) interaction site; other site 762376002032 biotinylation site [posttranslational modification]; other site 762376002033 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762376002034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376002035 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376002036 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376002037 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 762376002038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376002039 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 762376002040 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 762376002041 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 762376002042 substrate binding site [chemical binding]; other site 762376002043 ATP binding site [chemical binding]; other site 762376002044 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 762376002045 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376002046 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762376002047 DltD C-terminal region; Region: DltD_C; pfam04914 762376002048 MBOAT family; Region: MBOAT; cl00738 762376002049 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 762376002050 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376002051 YGGT family; Region: YGGT; cl00508 762376002052 YGGT family; Region: YGGT; cl00508 762376002053 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762376002054 dimer interface [polypeptide binding]; other site 762376002055 putative radical transfer pathway; other site 762376002056 diiron center [ion binding]; other site 762376002057 tyrosyl radical; other site 762376002058 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 762376002059 ATP cone domain; Region: ATP-cone; pfam03477 762376002060 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762376002061 active site 762376002062 dimer interface [polypeptide binding]; other site 762376002063 catalytic residues [active] 762376002064 effector binding site; other site 762376002065 R2 peptide binding site; other site 762376002066 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 762376002067 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376002068 dimer interface [polypeptide binding]; other site 762376002069 PYR/PP interface [polypeptide binding]; other site 762376002070 TPP binding site [chemical binding]; other site 762376002071 substrate binding site [chemical binding]; other site 762376002072 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762376002073 TPP-binding site [chemical binding]; other site 762376002074 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 762376002075 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376002080 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376002081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002083 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376002084 putative dimerization interface [polypeptide binding]; other site 762376002085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376002087 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762376002088 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762376002089 HIGH motif; other site 762376002090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762376002091 active site 762376002092 KMSKS motif; other site 762376002093 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376002094 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376002095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376002096 Isochorismatase family; Region: Isochorismatase; pfam00857 762376002097 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376002098 catalytic triad [active] 762376002099 conserved cis-peptide bond; other site 762376002100 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376002102 dimer interface [polypeptide binding]; other site 762376002103 conserved gate region; other site 762376002104 putative PBP binding loops; other site 762376002105 ABC-ATPase subunit interface; other site 762376002106 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376002107 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376002108 Walker A/P-loop; other site 762376002109 ATP binding site [chemical binding]; other site 762376002110 Q-loop/lid; other site 762376002111 ABC transporter signature motif; other site 762376002112 Walker B; other site 762376002113 D-loop; other site 762376002114 H-loop/switch region; other site 762376002115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002116 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376002117 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 762376002118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376002119 Protein of unknown function (DUF615); Region: DUF615; cl01147 762376002120 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 762376002121 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 762376002122 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376002123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376002124 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376002125 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376002126 TM-ABC transporter signature motif; other site 762376002127 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376002128 TM-ABC transporter signature motif; other site 762376002129 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376002130 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376002131 Walker A/P-loop; other site 762376002132 ATP binding site [chemical binding]; other site 762376002133 Q-loop/lid; other site 762376002134 ABC transporter signature motif; other site 762376002135 Walker B; other site 762376002136 D-loop; other site 762376002137 H-loop/switch region; other site 762376002138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376002139 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376002140 Walker A/P-loop; other site 762376002141 ATP binding site [chemical binding]; other site 762376002142 Q-loop/lid; other site 762376002143 ABC transporter signature motif; other site 762376002144 Walker B; other site 762376002145 D-loop; other site 762376002146 H-loop/switch region; other site 762376002147 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762376002148 23S rRNA interface [nucleotide binding]; other site 762376002149 L3 interface [polypeptide binding]; other site 762376002150 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 762376002151 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762376002152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002153 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 762376002154 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 762376002155 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 762376002156 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 762376002157 putative peptidase; Provisional; Region: PRK11649 762376002158 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376002159 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 762376002160 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762376002161 active site 762376002162 HIGH motif; other site 762376002163 dimer interface [polypeptide binding]; other site 762376002164 KMSKS motif; other site 762376002165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376002166 RNA binding surface [nucleotide binding]; other site 762376002167 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762376002168 substrate binding site [chemical binding]; other site 762376002169 LysE type translocator; Region: LysE; cl00565 762376002170 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 762376002171 dimer interface [polypeptide binding]; other site 762376002172 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762376002173 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762376002174 active site 762376002175 folate binding site [chemical binding]; other site 762376002176 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 762376002177 ATP cone domain; Region: ATP-cone; pfam03477 762376002178 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376002179 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376002180 conserved cys residue [active] 762376002181 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376002182 catalytic triad [active] 762376002183 conserved cis-peptide bond; other site 762376002184 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 762376002185 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 762376002186 catalytic motif [active] 762376002187 Zn binding site [ion binding]; other site 762376002188 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 762376002189 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 762376002190 PrkA family serine protein kinase; Provisional; Region: PRK15455 762376002191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376002192 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 762376002193 Protein of unknown function (DUF444); Region: DUF444; pfam04285 762376002194 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762376002195 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 762376002196 SpoVR family protein; Provisional; Region: PRK11767 762376002197 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 762376002198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002199 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002201 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376002202 putative dimerization interface [polypeptide binding]; other site 762376002203 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762376002204 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 762376002205 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 762376002206 dimerization interface [polypeptide binding]; other site 762376002207 active site 762376002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002210 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 762376002211 putative metal binding site [ion binding]; other site 762376002212 OsmC-like protein; Region: OsmC; cl00767 762376002213 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 762376002214 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762376002215 NAD binding site [chemical binding]; other site 762376002216 homotetramer interface [polypeptide binding]; other site 762376002217 homodimer interface [polypeptide binding]; other site 762376002218 substrate binding site [chemical binding]; other site 762376002219 active site 762376002220 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376002221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002222 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376002223 dimerization interface [polypeptide binding]; other site 762376002224 substrate binding pocket [chemical binding]; other site 762376002225 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 762376002226 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_2; cd06252 762376002227 putative active site [active] 762376002228 Zn-binding site [ion binding]; other site 762376002229 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 762376002230 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 762376002231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376002232 catalytic residue [active] 762376002233 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 762376002234 Uncharacterized conserved protein [Function unknown]; Region: COG4832 762376002235 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 762376002236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002237 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 762376002238 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376002239 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376002240 catalytic residue [active] 762376002241 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376002242 putative peptidoglycan binding site; other site 762376002243 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376002244 putative peptidoglycan binding site; other site 762376002245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376002246 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 762376002247 RNA/DNA hybrid binding site [nucleotide binding]; other site 762376002248 active site 762376002249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376002250 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762376002251 Proteobacterial; Region: dnaQ_proteo; TIGR01406 762376002252 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 762376002253 active site 762376002254 substrate binding site [chemical binding]; other site 762376002255 catalytic site [active] 762376002256 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 762376002257 LexA regulated protein; Provisional; Region: PRK11675 762376002258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002259 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 762376002260 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376002261 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376002262 Ligand binding site [chemical binding]; other site 762376002263 Putative Catalytic site [active] 762376002264 DXD motif; other site 762376002265 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376002266 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 762376002267 GtrA-like protein; Region: GtrA; cl00971 762376002268 YdjC-like protein; Region: YdjC; cl01344 762376002269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376002272 dimerization interface [polypeptide binding]; other site 762376002273 Predicted membrane protein [Function unknown]; Region: COG4125 762376002274 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 762376002275 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 762376002276 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376002277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002278 DNA-binding site [nucleotide binding]; DNA binding site 762376002279 FCD domain; Region: FCD; cl11656 762376002280 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376002281 TM-ABC transporter signature motif; other site 762376002282 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376002283 TM-ABC transporter signature motif; other site 762376002284 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376002285 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376002286 putative ligand binding site [chemical binding]; other site 762376002287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376002288 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376002289 Walker A/P-loop; other site 762376002290 ATP binding site [chemical binding]; other site 762376002291 Q-loop/lid; other site 762376002292 ABC transporter signature motif; other site 762376002293 Walker B; other site 762376002294 D-loop; other site 762376002295 H-loop/switch region; other site 762376002296 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376002297 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376002298 Walker A/P-loop; other site 762376002299 ATP binding site [chemical binding]; other site 762376002300 Q-loop/lid; other site 762376002301 ABC transporter signature motif; other site 762376002302 Walker B; other site 762376002303 D-loop; other site 762376002304 H-loop/switch region; other site 762376002305 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376002306 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376002307 inhibitor site; inhibition site 762376002308 active site 762376002309 dimer interface [polypeptide binding]; other site 762376002310 catalytic residue [active] 762376002311 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376002312 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376002313 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376002314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002315 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 762376002316 putative dimerization interface [polypeptide binding]; other site 762376002317 LrgA family; Region: LrgA; cl00608 762376002318 LrgB-like family; Region: LrgB; cl00596 762376002319 LysE type translocator; Region: LysE; cl00565 762376002320 EamA-like transporter family; Region: EamA; cl01037 762376002321 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376002322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002323 DNA-binding site [nucleotide binding]; DNA binding site 762376002324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376002325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002326 homodimer interface [polypeptide binding]; other site 762376002327 catalytic residue [active] 762376002328 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 762376002329 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376002330 Ligand Binding Site [chemical binding]; other site 762376002331 elongation factor G; Reviewed; Region: PRK00007 762376002332 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 762376002333 G1 box; other site 762376002334 putative GEF interaction site [polypeptide binding]; other site 762376002335 GTP/Mg2+ binding site [chemical binding]; other site 762376002336 Switch I region; other site 762376002337 G2 box; other site 762376002338 G3 box; other site 762376002339 Switch II region; other site 762376002340 G4 box; other site 762376002341 G5 box; other site 762376002342 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 762376002343 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 762376002344 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 762376002345 EamA-like transporter family; Region: EamA; cl01037 762376002346 EamA-like transporter family; Region: EamA; cl01037 762376002347 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376002350 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910 762376002351 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 762376002352 putative deacylase active site [active] 762376002353 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376002354 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376002355 Walker A/P-loop; other site 762376002356 ATP binding site [chemical binding]; other site 762376002357 Q-loop/lid; other site 762376002358 ABC transporter signature motif; other site 762376002359 Walker B; other site 762376002360 D-loop; other site 762376002361 H-loop/switch region; other site 762376002362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376002363 ABC-ATPase subunit interface; other site 762376002364 dimer interface [polypeptide binding]; other site 762376002365 putative PBP binding regions; other site 762376002366 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762376002367 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376002368 ligand binding site [chemical binding]; other site 762376002369 translocation protein TolB; Provisional; Region: tolB; PRK02889 762376002370 TolB amino-terminal domain; Region: TolB_N; pfam04052 762376002371 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002372 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002373 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002374 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002375 Gram-negative bacterial tonB protein; Region: TonB; cl10048 762376002376 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 762376002377 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376002378 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762376002379 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376002380 active site 762376002381 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762376002382 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 762376002383 dimer interface [polypeptide binding]; other site 762376002384 motif 1; other site 762376002385 active site 762376002386 motif 2; other site 762376002387 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 762376002388 putative deacylase active site [active] 762376002389 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762376002390 active site 762376002391 motif 3; other site 762376002392 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 762376002393 anticodon binding site; other site 762376002394 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 762376002395 putative active site [active] 762376002396 Ap4A binding site [chemical binding]; other site 762376002397 nudix motif; other site 762376002398 putative metal binding site [ion binding]; other site 762376002399 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376002400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376002401 active site 762376002402 phosphorylation site [posttranslational modification] 762376002403 intermolecular recognition site; other site 762376002404 dimerization interface [polypeptide binding]; other site 762376002405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376002406 DNA binding site [nucleotide binding] 762376002407 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376002408 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 762376002409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376002410 dimer interface [polypeptide binding]; other site 762376002411 phosphorylation site [posttranslational modification] 762376002412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376002413 ATP binding site [chemical binding]; other site 762376002414 Mg2+ binding site [ion binding]; other site 762376002415 G-X-G motif; other site 762376002416 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376002417 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376002418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002419 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376002420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002421 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376002422 putative effector binding pocket; other site 762376002423 putative dimerization interface [polypeptide binding]; other site 762376002424 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376002425 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376002426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002427 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376002428 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376002429 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376002430 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376002431 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 762376002432 Cell division protein ZapA; Region: ZapA; cl01146 762376002433 Protein of unknown function (DUF541); Region: SIMPL; cl01077 762376002434 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 762376002435 Dehydratase family; Region: ILVD_EDD; cl00340 762376002436 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376002437 Cytochrome c; Region: Cytochrom_C; cl11414 762376002438 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 762376002439 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 762376002440 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 762376002441 dimer interface [polypeptide binding]; other site 762376002442 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 762376002443 active site 762376002444 Fe binding site [ion binding]; other site 762376002445 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 762376002446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002447 Predicted membrane protein [Function unknown]; Region: COG3671 762376002448 SWIB/MDM2 domain; Region: SWIB; cl02489 762376002449 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376002450 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376002451 metal binding site [ion binding]; metal-binding site 762376002452 putative dimer interface [polypeptide binding]; other site 762376002453 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 762376002454 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 762376002455 active site 762376002456 substrate binding pocket [chemical binding]; other site 762376002457 dimer interface [polypeptide binding]; other site 762376002458 ABC transporter ATPase component; Reviewed; Region: PRK11147 762376002459 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376002460 ABC transporter; Region: ABC_tran_2; pfam12848 762376002461 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376002462 cell division protein MraZ; Reviewed; Region: PRK00326 762376002463 MraZ protein; Region: MraZ; pfam02381 762376002464 MraZ protein; Region: MraZ; pfam02381 762376002465 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 762376002466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376002467 Septum formation initiator; Region: DivIC; cl11433 762376002468 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762376002469 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762376002470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762376002471 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 762376002472 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002475 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002478 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762376002479 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 762376002480 Mg++ binding site [ion binding]; other site 762376002481 putative catalytic motif [active] 762376002482 putative substrate binding site [chemical binding]; other site 762376002483 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 762376002484 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002485 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002486 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 762376002487 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762376002488 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 762376002489 active site 762376002490 homodimer interface [polypeptide binding]; other site 762376002491 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762376002492 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002495 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 762376002496 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762376002497 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376002498 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 762376002499 Cell division protein FtsQ; Region: FtsQ; pfam03799 762376002500 cell division protein FtsA; Region: ftsA; TIGR01174 762376002501 Cell division protein FtsA; Region: FtsA; cl11496 762376002502 Cell division protein FtsA; Region: FtsA; cl11496 762376002503 cell division protein FtsZ; Validated; Region: PRK09330 762376002504 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 762376002505 nucleotide binding site [chemical binding]; other site 762376002506 SulA interaction site; other site 762376002507 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 762376002508 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 762376002509 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762376002510 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376002511 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762376002512 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762376002513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376002514 nucleotide binding region [chemical binding]; other site 762376002515 ATP-binding site [chemical binding]; other site 762376002516 SEC-C motif; Region: SEC-C; cl12132 762376002517 DNA helicase, putative; Region: TIGR00376 762376002518 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762376002519 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376002520 putative active site [active] 762376002521 catalytic site [active] 762376002522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376002523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002524 DNA-binding site [nucleotide binding]; DNA binding site 762376002525 FCD domain; Region: FCD; cl11656 762376002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002528 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376002529 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376002530 PYR/PP interface [polypeptide binding]; other site 762376002531 dimer interface [polypeptide binding]; other site 762376002532 TPP binding site [chemical binding]; other site 762376002533 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376002534 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376002535 TPP-binding site [chemical binding]; other site 762376002536 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376002537 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376002538 putative NAD(P) binding site [chemical binding]; other site 762376002539 putative active site [active] 762376002540 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002542 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376002543 putative active site pocket [active] 762376002544 dimerization interface [polypeptide binding]; other site 762376002545 putative catalytic residue [active] 762376002546 Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181 762376002547 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762376002548 MgtE intracellular N domain; Region: MgtE_N; cl15244 762376002549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762376002550 Divalent cation transporter; Region: MgtE; cl00786 762376002551 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 762376002552 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 762376002553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002554 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 762376002555 putative dimerization interface [polypeptide binding]; other site 762376002556 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376002557 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376002558 metal binding site [ion binding]; metal-binding site 762376002559 putative dimer interface [polypeptide binding]; other site 762376002560 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 762376002561 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376002562 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 762376002563 active site 762376002564 dimerization interface [polypeptide binding]; other site 762376002565 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 762376002566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376002567 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376002568 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 762376002569 active site 762376002570 catalytic site [active] 762376002571 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762376002572 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 762376002573 Walker A/P-loop; other site 762376002574 ATP binding site [chemical binding]; other site 762376002575 Q-loop/lid; other site 762376002576 ABC transporter signature motif; other site 762376002577 Walker B; other site 762376002578 D-loop; other site 762376002579 H-loop/switch region; other site 762376002580 NIL domain; Region: NIL; pfam09383 762376002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376002582 dimer interface [polypeptide binding]; other site 762376002583 conserved gate region; other site 762376002584 ABC-ATPase subunit interface; other site 762376002585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002586 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 762376002587 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376002588 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376002589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002590 metal binding site [ion binding]; metal-binding site 762376002591 active site 762376002592 I-site; other site 762376002593 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762376002594 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_6; cd06233 762376002595 putative active site [active] 762376002596 Zn-binding site [ion binding]; other site 762376002597 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_6; cd06233 762376002598 putative active site [active] 762376002599 Zn-binding site [ion binding]; other site 762376002600 citrate-proton symporter; Provisional; Region: PRK15075 762376002601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002602 putative substrate translocation pore; other site 762376002603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002604 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376002605 putative substrate translocation pore; other site 762376002606 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376002607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002609 dimerization interface [polypeptide binding]; other site 762376002610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376002611 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 762376002612 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376002613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002616 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376002617 Zn binding site [ion binding]; other site 762376002618 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376002619 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 762376002620 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376002621 metal binding site 2 [ion binding]; metal-binding site 762376002622 putative DNA binding helix; other site 762376002623 metal binding site 1 [ion binding]; metal-binding site 762376002624 dimer interface [polypeptide binding]; other site 762376002625 structural Zn2+ binding site [ion binding]; other site 762376002626 Cupin domain; Region: Cupin_2; cl09118 762376002627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376002628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376002629 Esterase/lipase [General function prediction only]; Region: COG1647 762376002630 Flagellin N-methylase; Region: FliB; cl00497 762376002631 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 762376002632 Sulfatase; Region: Sulfatase; cl10460 762376002633 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 762376002634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002635 metal binding site [ion binding]; metal-binding site 762376002636 active site 762376002637 I-site; other site 762376002638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376002639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376002640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376002641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002642 NAD(P) binding site [chemical binding]; other site 762376002643 active site 762376002644 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376002645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376002646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376002647 DNA binding residues [nucleotide binding] 762376002648 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376002649 FecR protein; Region: FecR; pfam04773 762376002650 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376002651 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376002652 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376002653 N-terminal plug; other site 762376002654 ligand-binding site [chemical binding]; other site 762376002655 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762376002656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376002657 motif II; other site 762376002658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002660 putative DNA binding site [nucleotide binding]; other site 762376002661 putative Zn2+ binding site [ion binding]; other site 762376002662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002663 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 762376002664 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376002665 aspartate aminotransferase; Provisional; Region: PRK08361 762376002666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376002667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002668 homodimer interface [polypeptide binding]; other site 762376002669 catalytic residue [active] 762376002670 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376002671 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 762376002672 metal binding site [ion binding]; metal-binding site 762376002673 putative dimer interface [polypeptide binding]; other site 762376002674 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376002675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002676 putative substrate translocation pore; other site 762376002677 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376002678 ligand binding site [chemical binding]; other site 762376002679 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 762376002680 aromatic arch; other site 762376002681 DCoH dimer interaction site [polypeptide binding]; other site 762376002682 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 762376002683 DCoH tetramer interaction site [polypeptide binding]; other site 762376002684 substrate binding site [chemical binding]; other site 762376002685 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376002686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002687 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376002688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376002689 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 762376002690 Substrate binding site [chemical binding]; other site 762376002691 metal binding site [ion binding]; metal-binding site 762376002692 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376002693 Phosphotransferase enzyme family; Region: APH; pfam01636 762376002694 OstA-like protein; Region: OstA; cl00844 762376002695 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 762376002696 Organic solvent tolerance protein; Region: OstA_C; pfam04453 762376002697 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 762376002698 SurA N-terminal domain; Region: SurA_N; pfam09312 762376002699 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376002700 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376002701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376002702 putative transposase OrfB; Reviewed; Region: PHA02517 762376002703 Integrase core domain; Region: rve; cl01316 762376002704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376002705 Glycerate kinase family; Region: Gly_kinase; cl00841 762376002706 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376002707 pyruvate kinase; Provisional; Region: PRK05826 762376002708 domain interfaces; other site 762376002709 active site 762376002710 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 762376002711 Nucleoside recognition; Region: Gate; cl00486 762376002712 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 762376002713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376002714 active site 762376002715 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 762376002716 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 762376002717 active site 762376002718 catalytic residues [active] 762376002719 metal binding site [ion binding]; metal-binding site 762376002720 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 762376002721 dimer interface [polypeptide binding]; other site 762376002722 active site 762376002723 metal binding site [ion binding]; metal-binding site 762376002724 glutathione binding site [chemical binding]; other site 762376002725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376002726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376002727 catalytic residue [active] 762376002728 Protein of unknown function DUF45; Region: DUF45; cl00636 762376002729 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376002730 putative acyl-acceptor binding pocket; other site 762376002731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376002732 active site 762376002733 motif I; other site 762376002734 motif II; other site 762376002735 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 762376002736 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 762376002737 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 762376002738 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 762376002739 dimer interface [polypeptide binding]; other site 762376002740 motif 1; other site 762376002741 active site 762376002742 motif 2; other site 762376002743 motif 3; other site 762376002744 enoyl-CoA hydratase; Provisional; Region: PRK08252 762376002745 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376002746 substrate binding site [chemical binding]; other site 762376002747 oxyanion hole (OAH) forming residues; other site 762376002748 trimer interface [polypeptide binding]; other site 762376002749 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 762376002750 Fumarase C-terminus; Region: Fumerase_C; cl00795 762376002751 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376002752 enoyl-CoA hydratase; Region: PLN02864 762376002753 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376002754 dimer interaction site [polypeptide binding]; other site 762376002755 substrate-binding tunnel; other site 762376002756 active site 762376002757 catalytic site [active] 762376002758 substrate binding site [chemical binding]; other site 762376002759 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 762376002760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002761 NAD(P) binding site [chemical binding]; other site 762376002762 active site 762376002763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002765 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376002766 putative dimerization interface [polypeptide binding]; other site 762376002767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002768 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376002769 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376002770 FMN binding site [chemical binding]; other site 762376002771 substrate binding site [chemical binding]; other site 762376002772 putative catalytic residue [active] 762376002773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002775 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376002776 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376002777 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376002778 thiolase; Provisional; Region: PRK06158 762376002779 active site 762376002780 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376002781 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376002782 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376002783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376002784 active site 762376002785 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376002786 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376002787 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376002788 active site 762376002789 enoyl-CoA hydratase; Provisional; Region: PRK08140 762376002790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376002791 substrate binding site [chemical binding]; other site 762376002792 oxyanion hole (OAH) forming residues; other site 762376002793 trimer interface [polypeptide binding]; other site 762376002794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376002797 putative dimerization interface [polypeptide binding]; other site 762376002798 Uncharacterized conserved protein [Function unknown]; Region: COG3777 762376002799 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376002800 active site 2 [active] 762376002801 active site 1 [active] 762376002802 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376002803 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376002804 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 762376002805 substrate binding site [chemical binding]; other site 762376002806 ATP binding site [chemical binding]; other site 762376002807 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 762376002808 catalytic center binding site [active] 762376002809 ATP binding site [chemical binding]; other site 762376002810 poly(A) polymerase; Region: pcnB; TIGR01942 762376002811 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762376002812 active site 762376002813 NTP binding site [chemical binding]; other site 762376002814 metal binding triad [ion binding]; metal-binding site 762376002815 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762376002816 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 762376002817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376002818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376002819 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762376002820 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 762376002821 dimerization interface [polypeptide binding]; other site 762376002822 putative ATP binding site [chemical binding]; other site 762376002823 IPP transferase; Region: IPPT; cl00403 762376002824 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762376002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376002826 ATP binding site [chemical binding]; other site 762376002827 Mg2+ binding site [ion binding]; other site 762376002828 G-X-G motif; other site 762376002829 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 762376002830 ATP binding site [chemical binding]; other site 762376002831 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 762376002832 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376002833 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 762376002834 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762376002835 active site 762376002836 metal binding site [ion binding]; metal-binding site 762376002837 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 762376002838 fumarate hydratase; Reviewed; Region: fumC; PRK00485 762376002839 Class II fumarases; Region: Fumarase_classII; cd01362 762376002840 active site 762376002841 tetramer interface [polypeptide binding]; other site 762376002842 Membrane transport protein; Region: Mem_trans; cl09117 762376002843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002845 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376002846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002848 dimerization interface [polypeptide binding]; other site 762376002849 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376002850 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376002851 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376002852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002853 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376002854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376002855 active site 762376002856 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376002857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002858 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 762376002859 putative dimerization interface [polypeptide binding]; other site 762376002860 putative substrate binding pocket [chemical binding]; other site 762376002861 putative transporter; Provisional; Region: PRK11660 762376002862 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376002863 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376002864 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 762376002865 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 762376002866 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 762376002867 putative active site [active] 762376002868 putative substrate binding site [chemical binding]; other site 762376002869 putative cosubstrate binding site; other site 762376002870 catalytic site [active] 762376002871 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376002872 Flavin Reductases; Region: FlaRed; cl00801 762376002873 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 762376002874 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376002875 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 762376002876 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376002877 putative active site pocket [active] 762376002878 dimerization interface [polypeptide binding]; other site 762376002879 putative catalytic residue [active] 762376002880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376002882 putative substrate translocation pore; other site 762376002883 macrolide transporter subunit MacA; Provisional; Region: PRK11578 762376002884 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 762376002885 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762376002886 Walker A/P-loop; other site 762376002887 ATP binding site [chemical binding]; other site 762376002888 Q-loop/lid; other site 762376002889 ABC transporter signature motif; other site 762376002890 Walker B; other site 762376002891 D-loop; other site 762376002892 H-loop/switch region; other site 762376002893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762376002894 FtsX-like permease family; Region: FtsX; pfam02687 762376002895 NodT family; Region: outer_NodT; TIGR01845 762376002896 Outer membrane efflux protein; Region: OEP; pfam02321 762376002897 Outer membrane efflux protein; Region: OEP; pfam02321 762376002898 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376002899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002900 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376002901 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376002902 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376002903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376002904 enoyl-CoA hydratase; Provisional; Region: PRK06494 762376002905 substrate binding site [chemical binding]; other site 762376002906 oxyanion hole (OAH) forming residues; other site 762376002907 trimer interface [polypeptide binding]; other site 762376002908 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 762376002909 putative ATP binding site [chemical binding]; other site 762376002910 putative substrate interface [chemical binding]; other site 762376002911 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 762376002912 [2Fe-2S] cluster binding site [ion binding]; other site 762376002913 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376002914 inter-subunit interface; other site 762376002915 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376002916 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376002917 iron-sulfur cluster [ion binding]; other site 762376002918 [2Fe-2S] cluster binding site [ion binding]; other site 762376002919 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376002920 putative alpha subunit interface [polypeptide binding]; other site 762376002921 putative active site [active] 762376002922 putative substrate binding site [chemical binding]; other site 762376002923 Fe binding site [ion binding]; other site 762376002924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002926 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376002927 substrate binding pocket [chemical binding]; other site 762376002928 dimerization interface [polypeptide binding]; other site 762376002929 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 762376002930 substrate-cofactor binding pocket; other site 762376002931 homodimer interface [polypeptide binding]; other site 762376002932 Aminotransferase class IV; Region: Aminotran_4; pfam01063 762376002933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002934 catalytic residue [active] 762376002935 aminodeoxychorismate synthase; Provisional; Region: PRK07508 762376002936 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762376002937 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 762376002938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376002939 Walker A/P-loop; other site 762376002940 ATP binding site [chemical binding]; other site 762376002941 Q-loop/lid; other site 762376002942 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762376002943 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 762376002944 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762376002945 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762376002946 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 762376002947 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762376002948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376002949 Walker A/P-loop; other site 762376002950 ATP binding site [chemical binding]; other site 762376002951 Q-loop/lid; other site 762376002952 ABC transporter signature motif; other site 762376002953 Walker B; other site 762376002954 D-loop; other site 762376002955 H-loop/switch region; other site 762376002956 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376002957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002958 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376002959 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 762376002960 active site 762376002961 intersubunit interface [polypeptide binding]; other site 762376002962 catalytic residue [active] 762376002963 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762376002964 substrate binding site [chemical binding]; other site 762376002965 ATP binding site [chemical binding]; other site 762376002966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376002968 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376002969 putative effector binding pocket; other site 762376002970 dimerization interface [polypeptide binding]; other site 762376002971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762376002972 active site 762376002973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376002974 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376002975 Walker A/P-loop; other site 762376002976 ATP binding site [chemical binding]; other site 762376002977 Q-loop/lid; other site 762376002978 ABC transporter signature motif; other site 762376002979 Walker B; other site 762376002980 D-loop; other site 762376002981 H-loop/switch region; other site 762376002982 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376002983 TM-ABC transporter signature motif; other site 762376002984 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376002985 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376002986 Walker A/P-loop; other site 762376002987 ATP binding site [chemical binding]; other site 762376002988 Q-loop/lid; other site 762376002989 ABC transporter signature motif; other site 762376002990 Walker B; other site 762376002991 D-loop; other site 762376002992 H-loop/switch region; other site 762376002993 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376002994 TM-ABC transporter signature motif; other site 762376002995 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376002996 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376002997 putative ligand binding site [chemical binding]; other site 762376002998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376002999 classical (c) SDRs; Region: SDR_c; cd05233 762376003000 NAD(P) binding site [chemical binding]; other site 762376003001 active site 762376003002 Putative cyclase; Region: Cyclase; cl00814 762376003003 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376003004 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376003005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376003006 NAD(P) binding site [chemical binding]; other site 762376003007 active site 762376003008 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376003009 active site 762376003010 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376003011 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376003012 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376003013 inter-subunit interface; other site 762376003014 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 762376003015 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376003016 iron-sulfur cluster [ion binding]; other site 762376003017 [2Fe-2S] cluster binding site [ion binding]; other site 762376003018 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 762376003019 putative alpha subunit interface [polypeptide binding]; other site 762376003020 putative active site [active] 762376003021 putative substrate binding site [chemical binding]; other site 762376003022 Fe binding site [ion binding]; other site 762376003023 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376003024 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 762376003025 FMN-binding pocket [chemical binding]; other site 762376003026 flavin binding motif; other site 762376003027 phosphate binding motif [ion binding]; other site 762376003028 beta-alpha-beta structure motif; other site 762376003029 NAD binding pocket [chemical binding]; other site 762376003030 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376003031 catalytic loop [active] 762376003032 iron binding site [ion binding]; other site 762376003033 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 762376003034 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 762376003035 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 762376003036 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376003037 dimer interface [polypeptide binding]; other site 762376003038 PYR/PP interface [polypeptide binding]; other site 762376003039 TPP binding site [chemical binding]; other site 762376003040 substrate binding site [chemical binding]; other site 762376003041 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 762376003042 TPP-binding site; other site 762376003043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003044 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376003045 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376003046 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376003047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376003048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003049 dimer interface [polypeptide binding]; other site 762376003050 conserved gate region; other site 762376003051 putative PBP binding loops; other site 762376003052 ABC-ATPase subunit interface; other site 762376003053 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376003054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003055 dimer interface [polypeptide binding]; other site 762376003056 conserved gate region; other site 762376003057 putative PBP binding loops; other site 762376003058 ABC-ATPase subunit interface; other site 762376003059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376003060 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003061 Walker A/P-loop; other site 762376003062 ATP binding site [chemical binding]; other site 762376003063 Q-loop/lid; other site 762376003064 ABC transporter signature motif; other site 762376003065 Walker B; other site 762376003066 D-loop; other site 762376003067 H-loop/switch region; other site 762376003068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003069 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376003070 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003071 Walker A/P-loop; other site 762376003072 ATP binding site [chemical binding]; other site 762376003073 Q-loop/lid; other site 762376003074 ABC transporter signature motif; other site 762376003075 Walker B; other site 762376003076 D-loop; other site 762376003077 H-loop/switch region; other site 762376003078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003079 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376003080 EamA-like transporter family; Region: EamA; cl01037 762376003081 EamA-like transporter family; Region: EamA; cl01037 762376003082 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 762376003083 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376003084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376003085 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376003086 ABC transporter; Region: ABC_tran_2; pfam12848 762376003087 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376003088 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 762376003089 Isochorismatase family; Region: Isochorismatase; pfam00857 762376003090 catalytic triad [active] 762376003091 dimer interface [polypeptide binding]; other site 762376003092 conserved cis-peptide bond; other site 762376003093 Septum formation topological specificity factor MinE; Region: MinE; cl00538 762376003094 cell division inhibitor MinD; Provisional; Region: PRK10818 762376003095 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 762376003096 Switch I; other site 762376003097 Switch II; other site 762376003098 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 762376003099 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 762376003100 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 762376003101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376003102 active site 762376003103 HIGH motif; other site 762376003104 nucleotide binding site [chemical binding]; other site 762376003105 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 762376003106 KMSKS motif; other site 762376003107 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 762376003108 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 762376003109 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376003110 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376003111 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 762376003112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376003113 ATP binding site [chemical binding]; other site 762376003114 putative Mg++ binding site [ion binding]; other site 762376003115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003116 nucleotide binding region [chemical binding]; other site 762376003117 ATP-binding site [chemical binding]; other site 762376003118 RQC domain; Region: RQC; pfam09382 762376003119 HRDC domain; Region: HRDC; cl02578 762376003120 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376003121 osmolarity response regulator; Provisional; Region: ompR; PRK09468 762376003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003123 active site 762376003124 phosphorylation site [posttranslational modification] 762376003125 intermolecular recognition site; other site 762376003126 dimerization interface [polypeptide binding]; other site 762376003127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376003128 DNA binding site [nucleotide binding] 762376003129 sensor protein RstB; Provisional; Region: PRK10604 762376003130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003131 ATP binding site [chemical binding]; other site 762376003132 Mg2+ binding site [ion binding]; other site 762376003133 G-X-G motif; other site 762376003134 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762376003135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376003136 Walker A motif; other site 762376003137 ATP binding site [chemical binding]; other site 762376003138 Walker B motif; other site 762376003139 arginine finger; other site 762376003140 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762376003141 serine/threonine dehydratase; Validated; Region: PRK07048 762376003142 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376003143 tetramer interface [polypeptide binding]; other site 762376003144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376003145 catalytic residue [active] 762376003146 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762376003147 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 762376003148 putative NAD(P) binding site [chemical binding]; other site 762376003149 active site 762376003150 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762376003151 RuvA N terminal domain; Region: RuvA_N; pfam01330 762376003152 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 762376003153 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 762376003154 active site 762376003155 putative DNA-binding cleft [nucleotide binding]; other site 762376003156 dimer interface [polypeptide binding]; other site 762376003157 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762376003158 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 762376003159 purine monophosphate binding site [chemical binding]; other site 762376003160 dimer interface [polypeptide binding]; other site 762376003161 putative catalytic residues [active] 762376003162 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762376003163 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762376003164 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376003165 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 762376003166 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 762376003167 FMN binding site [chemical binding]; other site 762376003168 active site 762376003169 catalytic residues [active] 762376003170 substrate binding site [chemical binding]; other site 762376003171 hypothetical protein; Provisional; Region: PRK06996 762376003172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376003173 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 762376003174 proline aminopeptidase P II; Provisional; Region: PRK10879 762376003175 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 762376003176 active site 762376003177 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 762376003178 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 762376003179 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 762376003180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376003182 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762376003183 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376003184 trimer interface [polypeptide binding]; other site 762376003185 eyelet of channel; other site 762376003186 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 762376003187 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 762376003188 DNA binding residues [nucleotide binding] 762376003189 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 762376003190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376003191 non-specific DNA binding site [nucleotide binding]; other site 762376003192 salt bridge; other site 762376003193 sequence-specific DNA binding site [nucleotide binding]; other site 762376003194 Cupin domain; Region: Cupin_2; cl09118 762376003195 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376003196 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376003197 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762376003198 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762376003199 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762376003200 active site 762376003201 tetramer interface [polypeptide binding]; other site 762376003202 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 762376003203 Peptidase family M48; Region: Peptidase_M48; cl12018 762376003204 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 762376003205 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376003206 Zinc-finger domain; Region: zf-CHCC; cl01821 762376003207 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 762376003208 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 762376003209 homodimer interface [polypeptide binding]; other site 762376003210 substrate-cofactor binding pocket; other site 762376003211 catalytic residue [active] 762376003212 AzlC protein; Region: AzlC; cl00570 762376003213 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 762376003214 helicase 45; Provisional; Region: PTZ00424 762376003215 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762376003216 ATP binding site [chemical binding]; other site 762376003217 Mg++ binding site [ion binding]; other site 762376003218 motif III; other site 762376003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003220 nucleotide binding region [chemical binding]; other site 762376003221 ATP-binding site [chemical binding]; other site 762376003222 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376003223 catalytic residues [active] 762376003224 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 762376003225 putative MPT binding site; other site 762376003226 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003227 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003228 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003231 Phasin protein; Region: Phasin_2; cl11491 762376003232 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 762376003233 quinone interaction residues [chemical binding]; other site 762376003234 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 762376003235 active site 762376003236 catalytic residues [active] 762376003237 FMN binding site [chemical binding]; other site 762376003238 substrate binding site [chemical binding]; other site 762376003239 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 762376003240 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 762376003241 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 762376003242 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 762376003243 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 762376003244 nudix motif; other site 762376003245 transcriptional regulator; Provisional; Region: PRK10632 762376003246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376003248 putative effector binding pocket; other site 762376003249 dimerization interface [polypeptide binding]; other site 762376003250 DoxX; Region: DoxX; cl00976 762376003251 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376003252 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 762376003253 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174 762376003254 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003255 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003256 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003257 Fimbrial Usher protein; Region: Usher; pfam00577 762376003258 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 762376003259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376003260 dimer interface [polypeptide binding]; other site 762376003261 phosphorylation site [posttranslational modification] 762376003262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003263 ATP binding site [chemical binding]; other site 762376003264 Mg2+ binding site [ion binding]; other site 762376003265 G-X-G motif; other site 762376003266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003267 active site 762376003268 phosphorylation site [posttranslational modification] 762376003269 intermolecular recognition site; other site 762376003270 dimerization interface [polypeptide binding]; other site 762376003271 Response regulator receiver domain; Region: Response_reg; pfam00072 762376003272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003273 active site 762376003274 phosphorylation site [posttranslational modification] 762376003275 intermolecular recognition site; other site 762376003276 dimerization interface [polypeptide binding]; other site 762376003277 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376003278 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 762376003279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376003280 dimer interface [polypeptide binding]; other site 762376003281 phosphorylation site [posttranslational modification] 762376003282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003283 ATP binding site [chemical binding]; other site 762376003284 Mg2+ binding site [ion binding]; other site 762376003285 G-X-G motif; other site 762376003286 Response regulator receiver domain; Region: Response_reg; pfam00072 762376003287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003288 active site 762376003289 phosphorylation site [posttranslational modification] 762376003290 intermolecular recognition site; other site 762376003291 dimerization interface [polypeptide binding]; other site 762376003292 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 762376003293 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376003294 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376003295 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762376003296 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376003297 Magnesium ion binding site [ion binding]; other site 762376003298 ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 762376003299 ParB-like nuclease domain; Region: ParBc; cl02129 762376003300 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 762376003301 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 762376003302 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 762376003303 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376003304 ssDNA binding site [nucleotide binding]; other site 762376003305 dimer interface [polypeptide binding]; other site 762376003306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376003307 DNA topoisomerase III; Provisional; Region: PRK07726 762376003308 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376003309 active site 762376003310 putative interdomain interaction site [polypeptide binding]; other site 762376003311 putative metal-binding site [ion binding]; other site 762376003312 putative nucleotide binding site [chemical binding]; other site 762376003313 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 762376003314 domain I; other site 762376003315 DNA binding groove [nucleotide binding] 762376003316 phosphate binding site [ion binding]; other site 762376003317 domain II; other site 762376003318 domain III; other site 762376003319 nucleotide binding site [chemical binding]; other site 762376003320 catalytic site [active] 762376003321 domain IV; other site 762376003322 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 762376003323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376003324 cofactor binding site; other site 762376003325 DNA binding site [nucleotide binding] 762376003326 substrate interaction site [chemical binding]; other site 762376003327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376003328 putative transcriptional regulator MerR; Provisional; Region: PRK13752 762376003329 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 762376003330 DNA binding residues [nucleotide binding] 762376003331 dimer interface [polypeptide binding]; other site 762376003332 mercury binding site [ion binding]; other site 762376003333 MerT mercuric transport protein; Region: MerT; cl03578 762376003334 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376003335 metal-binding site [ion binding] 762376003336 putative mercuric reductase; Provisional; Region: PRK13748 762376003337 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376003338 metal-binding site [ion binding] 762376003339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376003340 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376003341 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 762376003342 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 762376003343 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 762376003344 Domain of unknown function (DUF932); Region: DUF932; cl12129 762376003345 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 762376003346 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 762376003347 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762376003348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003349 nucleotide binding region [chemical binding]; other site 762376003350 ATP-binding site [chemical binding]; other site 762376003351 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376003352 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376003353 catalytic residues [active] 762376003354 Membrane transport protein; Region: Mem_trans; cl09117 762376003355 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376003356 Active site [active] 762376003357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376003358 dimerization interface [polypeptide binding]; other site 762376003359 putative DNA binding site [nucleotide binding]; other site 762376003360 putative Zn2+ binding site [ion binding]; other site 762376003361 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 762376003362 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 762376003363 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376003364 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 762376003365 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 762376003366 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 762376003367 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 762376003368 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; cl09893 762376003369 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 762376003370 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 762376003371 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 762376003372 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 762376003373 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 762376003374 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 762376003375 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 762376003376 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 762376003377 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 762376003378 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376003379 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762376003380 MPN+ (JAMM) motif; other site 762376003381 Zinc-binding site [ion binding]; other site 762376003382 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 762376003383 TraU protein; Region: TraU; cl06067 762376003384 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 762376003385 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 762376003386 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 762376003387 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 762376003388 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 762376003389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376003390 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 762376003391 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762376003392 sensor kinase CusS; Provisional; Region: PRK09835 762376003393 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376003394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376003395 dimer interface [polypeptide binding]; other site 762376003396 phosphorylation site [posttranslational modification] 762376003397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003398 ATP binding site [chemical binding]; other site 762376003399 Mg2+ binding site [ion binding]; other site 762376003400 G-X-G motif; other site 762376003401 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 762376003402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003403 active site 762376003404 phosphorylation site [posttranslational modification] 762376003405 intermolecular recognition site; other site 762376003406 dimerization interface [polypeptide binding]; other site 762376003407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376003408 DNA binding site [nucleotide binding] 762376003409 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376003410 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376003411 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376003412 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 762376003413 Protein of unknown function, DUF; Region: DUF411; cl01142 762376003414 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 762376003415 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 762376003416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376003417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376003419 Copper resistance protein CopC; Region: CopC; cl01012 762376003420 Copper resistance protein D; Region: CopD; cl00563 762376003421 Copper resistance protein K; Region: CopK; pfam11525 762376003422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003424 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376003425 dimerization interface [polypeptide binding]; other site 762376003426 substrate binding pocket [chemical binding]; other site 762376003427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376003428 non-specific DNA binding site [nucleotide binding]; other site 762376003429 salt bridge; other site 762376003430 sequence-specific DNA binding site [nucleotide binding]; other site 762376003431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003432 dimerization interface [polypeptide binding]; other site 762376003433 Transposase domain (DUF772); Region: DUF772; cl12084 762376003434 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376003435 Outer membrane efflux protein; Region: OEP; pfam02321 762376003436 Outer membrane efflux protein; Region: OEP; pfam02321 762376003437 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 762376003438 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 762376003439 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 762376003440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003441 integrase; Provisional; Region: PRK09692 762376003442 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 762376003443 active site 762376003444 Int/Topo IB signature motif; other site 762376003445 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 762376003446 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 762376003447 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 762376003448 Iron-sulfur protein interface; other site 762376003449 proximal heme binding site [chemical binding]; other site 762376003450 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 762376003451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376003452 domain; Region: Succ_DH_flav_C; pfam02910 762376003453 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 762376003454 Fumarase C-terminus; Region: Fumerase_C; cl00795 762376003455 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376003456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003458 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376003459 putative dimerization interface [polypeptide binding]; other site 762376003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003462 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376003463 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376003464 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376003465 tetrameric interface [polypeptide binding]; other site 762376003466 NAD binding site [chemical binding]; other site 762376003467 catalytic residues [active] 762376003468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376003471 putative effector binding pocket; other site 762376003472 dimerization interface [polypeptide binding]; other site 762376003473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003475 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376003476 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376003477 PYR/PP interface [polypeptide binding]; other site 762376003478 dimer interface [polypeptide binding]; other site 762376003479 TPP binding site [chemical binding]; other site 762376003480 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376003481 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762376003482 TPP-binding site [chemical binding]; other site 762376003483 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762376003484 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762376003485 tetramer interface [polypeptide binding]; other site 762376003486 heme binding pocket [chemical binding]; other site 762376003487 NADPH binding site [chemical binding]; other site 762376003488 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 762376003489 FAD binding domain; Region: FAD_binding_4; pfam01565 762376003490 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762376003491 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762376003492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376003493 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762376003494 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 762376003495 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376003496 metal binding site 2 [ion binding]; metal-binding site 762376003497 putative DNA binding helix; other site 762376003498 metal binding site 1 [ion binding]; metal-binding site 762376003499 dimer interface [polypeptide binding]; other site 762376003500 structural Zn2+ binding site [ion binding]; other site 762376003501 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762376003502 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 762376003503 Walker A/P-loop; other site 762376003504 ATP binding site [chemical binding]; other site 762376003505 Q-loop/lid; other site 762376003506 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 762376003507 ABC transporter signature motif; other site 762376003508 Walker B; other site 762376003509 D-loop; other site 762376003510 H-loop/switch region; other site 762376003511 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 762376003512 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 762376003513 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762376003514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003515 HrcA protein C terminal domain; Region: HrcA; pfam01628 762376003516 ferrochelatase; Reviewed; Region: hemH; PRK00035 762376003517 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 762376003518 C-terminal domain interface [polypeptide binding]; other site 762376003519 active site 762376003520 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 762376003521 active site 762376003522 N-terminal domain interface [polypeptide binding]; other site 762376003523 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 762376003524 dimer interface [polypeptide binding]; other site 762376003525 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762376003526 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376003527 catalytic residues [active] 762376003528 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762376003529 chaperone protein DnaJ; Provisional; Region: PRK10767 762376003530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 762376003531 HSP70 interaction site [polypeptide binding]; other site 762376003532 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 762376003533 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 762376003534 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762376003535 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762376003536 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762376003537 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762376003538 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762376003539 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376003540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376003541 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376003542 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762376003543 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376003545 Walker A motif; other site 762376003546 ATP binding site [chemical binding]; other site 762376003547 Walker B motif; other site 762376003548 arginine finger; other site 762376003549 Cytochrome c; Region: Cytochrom_C; cl11414 762376003550 Cytochrome c; Region: Cytochrom_C; cl11414 762376003551 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 762376003552 isocitrate dehydrogenase; Validated; Region: PRK07362 762376003553 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762376003554 O-Antigen ligase; Region: Wzy_C; cl04850 762376003555 Cache domain; Region: Cache_2; pfam08269 762376003556 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376003557 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 762376003558 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376003559 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376003560 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376003561 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762376003562 dimer interface [polypeptide binding]; other site 762376003563 active site 762376003564 catalytic residue [active] 762376003565 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 762376003566 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 762376003567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376003568 active site 762376003569 phosphorylation site [posttranslational modification] 762376003570 intermolecular recognition site; other site 762376003571 dimerization interface [polypeptide binding]; other site 762376003572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376003573 DNA binding site [nucleotide binding] 762376003574 sensor protein KdpD; Provisional; Region: PRK10490 762376003575 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 762376003576 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 762376003577 Ligand Binding Site [chemical binding]; other site 762376003578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376003579 dimer interface [polypeptide binding]; other site 762376003580 phosphorylation site [posttranslational modification] 762376003581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003582 ATP binding site [chemical binding]; other site 762376003583 Mg2+ binding site [ion binding]; other site 762376003584 G-X-G motif; other site 762376003585 K+-transporting ATPase, c chain; Region: KdpC; cl00944 762376003586 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 762376003587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376003589 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 762376003590 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 762376003591 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 762376003592 Sodium:solute symporter family; Region: SSF; cl00456 762376003593 Sodium:solute symporter family; Region: SSF; cl00456 762376003594 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376003595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 762376003596 Smr domain; Region: Smr; cl02619 762376003597 thioredoxin reductase; Provisional; Region: PRK10262 762376003598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376003599 DNA translocase FtsK; Provisional; Region: PRK10263 762376003600 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 762376003601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376003602 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 762376003603 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 762376003604 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 762376003605 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376003606 homotrimer interaction site [polypeptide binding]; other site 762376003607 putative active site [active] 762376003608 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376003609 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376003610 active site 762376003611 putative substrate binding pocket [chemical binding]; other site 762376003612 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376003613 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376003614 putative active site [active] 762376003615 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376003616 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003617 Walker A/P-loop; other site 762376003618 ATP binding site [chemical binding]; other site 762376003619 Q-loop/lid; other site 762376003620 ABC transporter signature motif; other site 762376003621 Walker B; other site 762376003622 D-loop; other site 762376003623 H-loop/switch region; other site 762376003624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003625 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376003626 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003627 Walker A/P-loop; other site 762376003628 ATP binding site [chemical binding]; other site 762376003629 Q-loop/lid; other site 762376003630 ABC transporter signature motif; other site 762376003631 Walker B; other site 762376003632 D-loop; other site 762376003633 H-loop/switch region; other site 762376003634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003635 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376003636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003637 dimer interface [polypeptide binding]; other site 762376003638 conserved gate region; other site 762376003639 putative PBP binding loops; other site 762376003640 ABC-ATPase subunit interface; other site 762376003641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003643 dimer interface [polypeptide binding]; other site 762376003644 conserved gate region; other site 762376003645 putative PBP binding loops; other site 762376003646 ABC-ATPase subunit interface; other site 762376003647 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376003648 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376003649 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376003650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 762376003651 dimer interface [polypeptide binding]; other site 762376003652 active site 762376003653 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376003654 substrate binding site [chemical binding]; other site 762376003655 catalytic residue [active] 762376003656 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376003657 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 762376003658 putative active site [active] 762376003659 catalytic triad [active] 762376003660 putative dimer interface [polypeptide binding]; other site 762376003661 recombination factor protein RarA; Reviewed; Region: PRK13342 762376003662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376003663 Walker A motif; other site 762376003664 ATP binding site [chemical binding]; other site 762376003665 Walker B motif; other site 762376003666 arginine finger; other site 762376003667 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 762376003668 seryl-tRNA synthetase; Provisional; Region: PRK05431 762376003669 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762376003670 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762376003671 dimer interface [polypeptide binding]; other site 762376003672 active site 762376003673 motif 1; other site 762376003674 motif 2; other site 762376003675 motif 3; other site 762376003676 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 762376003677 cytosine deaminase; Provisional; Region: PRK05985 762376003678 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 762376003679 active site 762376003680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376003683 putative dimerization interface [polypeptide binding]; other site 762376003684 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 762376003685 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 762376003686 active site pocket [active] 762376003687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003689 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 762376003690 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 762376003691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376003692 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376003693 trimer interface [polypeptide binding]; other site 762376003694 eyelet of channel; other site 762376003695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003696 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003697 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376003699 putative substrate translocation pore; other site 762376003700 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376003701 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376003702 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 762376003703 putative active site [active] 762376003704 catalytic triad [active] 762376003705 putative dimer interface [polypeptide binding]; other site 762376003706 Flavin Reductases; Region: FlaRed; cl00801 762376003707 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762376003708 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762376003709 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762376003710 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 762376003711 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 762376003712 NAD binding site [chemical binding]; other site 762376003713 homotetramer interface [polypeptide binding]; other site 762376003714 homodimer interface [polypeptide binding]; other site 762376003715 substrate binding site [chemical binding]; other site 762376003716 active site 762376003717 Protein of unknown function (DUF328); Region: DUF328; cl01143 762376003718 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 762376003719 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 762376003720 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 762376003721 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376003722 PYR/PP interface [polypeptide binding]; other site 762376003723 dimer interface [polypeptide binding]; other site 762376003724 TPP binding site [chemical binding]; other site 762376003725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376003726 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762376003727 TPP-binding site [chemical binding]; other site 762376003728 dimer interface [polypeptide binding]; other site 762376003729 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 762376003730 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 762376003731 putative valine binding site [chemical binding]; other site 762376003732 dimer interface [polypeptide binding]; other site 762376003733 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 762376003734 ketol-acid reductoisomerase; Provisional; Region: PRK05479 762376003735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376003736 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 762376003737 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762376003738 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 762376003739 16S/18S rRNA binding site [nucleotide binding]; other site 762376003740 S13e-L30e interaction site [polypeptide binding]; other site 762376003741 25S rRNA binding site [nucleotide binding]; other site 762376003742 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 762376003743 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 762376003744 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 762376003745 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 762376003746 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 762376003747 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 762376003748 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 762376003749 putative nucleic acid binding region [nucleotide binding]; other site 762376003750 G-X-X-G motif; other site 762376003751 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 762376003752 RNA binding site [nucleotide binding]; other site 762376003753 domain interface; other site 762376003754 threonine dehydratase; Provisional; Region: PRK07334 762376003755 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376003756 tetramer interface [polypeptide binding]; other site 762376003757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376003758 catalytic residue [active] 762376003759 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 762376003760 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376003761 GST_C family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its...; Region: GST_C_Metaxin; cd03193 762376003762 putative N-terminal domain interface [polypeptide binding]; other site 762376003763 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 762376003764 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376003765 putative active site [active] 762376003766 catalytic triad [active] 762376003767 putative dimer interface [polypeptide binding]; other site 762376003768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003770 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 762376003771 putative substrate binding pocket [chemical binding]; other site 762376003772 putative dimerization interface [polypeptide binding]; other site 762376003773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376003774 binding surface 762376003775 TPR motif; other site 762376003776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376003777 binding surface 762376003778 TPR motif; other site 762376003779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376003780 binding surface 762376003781 TPR motif; other site 762376003782 RDD family; Region: RDD; cl00746 762376003783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003786 dimerization interface [polypeptide binding]; other site 762376003787 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376003788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003790 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376003791 active site 762376003792 catalytic residues [active] 762376003793 metal binding site [ion binding]; metal-binding site 762376003794 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376003795 Ligand Binding Site [chemical binding]; other site 762376003796 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376003797 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376003798 NAD(P) binding site [chemical binding]; other site 762376003799 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762376003800 substrate binding site [chemical binding]; other site 762376003801 dimer interface [polypeptide binding]; other site 762376003802 catalytic triad [active] 762376003803 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376003804 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376003805 putative active site [active] 762376003806 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 762376003807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376003808 active site 762376003809 motif I; other site 762376003810 motif II; other site 762376003811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003812 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 762376003813 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 762376003814 Walker A/P-loop; other site 762376003815 ATP binding site [chemical binding]; other site 762376003816 Q-loop/lid; other site 762376003817 ABC transporter signature motif; other site 762376003818 Walker B; other site 762376003819 D-loop; other site 762376003820 H-loop/switch region; other site 762376003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003822 dimer interface [polypeptide binding]; other site 762376003823 conserved gate region; other site 762376003824 putative PBP binding loops; other site 762376003825 ABC-ATPase subunit interface; other site 762376003826 Pseudomonas-type; Region: PC_PLC; TIGR03396 762376003827 Phosphoesterase family; Region: Phosphoesterase; cl10627 762376003828 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376003829 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376003830 YadA-like C-terminal region; Region: YadA; pfam03895 762376003831 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376003832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003834 dimerization interface [polypeptide binding]; other site 762376003835 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 762376003836 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 762376003837 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376003838 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 762376003839 phosphate binding site [ion binding]; other site 762376003840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003842 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376003843 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 762376003844 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376003845 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 762376003846 Walker A/P-loop; other site 762376003847 ATP binding site [chemical binding]; other site 762376003848 Q-loop/lid; other site 762376003849 ABC transporter signature motif; other site 762376003850 Walker B; other site 762376003851 D-loop; other site 762376003852 H-loop/switch region; other site 762376003853 TOBE domain; Region: TOBE_2; cl01440 762376003854 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376003855 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376003856 NAD(P) binding site [chemical binding]; other site 762376003857 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376003858 putative C-terminal domain interface [polypeptide binding]; other site 762376003859 putative GSH binding site (G-site) [chemical binding]; other site 762376003860 putative dimer interface [polypeptide binding]; other site 762376003861 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 762376003862 N-terminal domain interface [polypeptide binding]; other site 762376003863 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762376003864 trimer interface [polypeptide binding]; other site 762376003865 active site 762376003866 dimer interface [polypeptide binding]; other site 762376003867 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376003868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003870 dimer interface [polypeptide binding]; other site 762376003871 conserved gate region; other site 762376003872 putative PBP binding loops; other site 762376003873 ABC-ATPase subunit interface; other site 762376003874 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376003875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003876 putative PBP binding loops; other site 762376003877 dimer interface [polypeptide binding]; other site 762376003878 ABC-ATPase subunit interface; other site 762376003879 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376003880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003881 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376003882 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376003883 Walker A/P-loop; other site 762376003884 ATP binding site [chemical binding]; other site 762376003885 Q-loop/lid; other site 762376003886 ABC transporter signature motif; other site 762376003887 Walker B; other site 762376003888 D-loop; other site 762376003889 H-loop/switch region; other site 762376003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003891 dimer interface [polypeptide binding]; other site 762376003892 conserved gate region; other site 762376003893 putative PBP binding loops; other site 762376003894 ABC-ATPase subunit interface; other site 762376003895 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376003896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003897 dimer interface [polypeptide binding]; other site 762376003898 conserved gate region; other site 762376003899 putative PBP binding loops; other site 762376003900 ABC-ATPase subunit interface; other site 762376003901 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376003902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376003903 substrate binding pocket [chemical binding]; other site 762376003904 membrane-bound complex binding site; other site 762376003905 hinge residues; other site 762376003906 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376003907 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376003908 homotrimer interaction site [polypeptide binding]; other site 762376003909 putative active site [active] 762376003910 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 762376003911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376003913 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376003914 putative substrate binding pocket [chemical binding]; other site 762376003915 dimerization interface [polypeptide binding]; other site 762376003916 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 762376003917 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376003918 metal binding site [ion binding]; metal-binding site 762376003919 putative dimer interface [polypeptide binding]; other site 762376003920 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 762376003921 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376003922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376003923 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376003924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376003925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376003926 enoyl-CoA hydratase; Provisional; Region: PRK08259 762376003927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376003928 substrate binding site [chemical binding]; other site 762376003929 oxyanion hole (OAH) forming residues; other site 762376003930 trimer interface [polypeptide binding]; other site 762376003931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376003932 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 762376003933 NAD(P) binding site [chemical binding]; other site 762376003934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376003937 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376003938 active site 762376003939 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376003940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376003941 non-specific DNA binding site [nucleotide binding]; other site 762376003942 salt bridge; other site 762376003943 sequence-specific DNA binding site [nucleotide binding]; other site 762376003944 Cupin domain; Region: Cupin_2; cl09118 762376003945 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376003946 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376003947 active site 762376003948 putative substrate binding pocket [chemical binding]; other site 762376003949 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376003950 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003951 Walker A/P-loop; other site 762376003952 ATP binding site [chemical binding]; other site 762376003953 Q-loop/lid; other site 762376003954 ABC transporter signature motif; other site 762376003955 Walker B; other site 762376003956 D-loop; other site 762376003957 H-loop/switch region; other site 762376003958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003959 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376003960 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376003961 Walker A/P-loop; other site 762376003962 ATP binding site [chemical binding]; other site 762376003963 Q-loop/lid; other site 762376003964 ABC transporter signature motif; other site 762376003965 Walker B; other site 762376003966 D-loop; other site 762376003967 H-loop/switch region; other site 762376003968 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003970 dimer interface [polypeptide binding]; other site 762376003971 conserved gate region; other site 762376003972 putative PBP binding loops; other site 762376003973 ABC-ATPase subunit interface; other site 762376003974 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376003976 dimer interface [polypeptide binding]; other site 762376003977 conserved gate region; other site 762376003978 putative PBP binding loops; other site 762376003979 ABC-ATPase subunit interface; other site 762376003980 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376003981 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376003982 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376003983 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376003984 MlrC C-terminus; Region: MlrC_C; pfam07171 762376003985 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376003986 homotrimer interaction site [polypeptide binding]; other site 762376003987 putative active site [active] 762376003988 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376003989 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 762376003990 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 762376003991 dimer interface [polypeptide binding]; other site 762376003992 putative tRNA-binding site [nucleotide binding]; other site 762376003993 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 762376003994 dimer interface [polypeptide binding]; other site 762376003995 FMN binding site [chemical binding]; other site 762376003996 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 762376003997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 762376003998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003999 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 762376004000 META domain; Region: META; cl01245 762376004001 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376004002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376004004 fec operon regulator FecR; Reviewed; Region: PRK09774 762376004005 FecR protein; Region: FecR; pfam04773 762376004006 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376004007 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376004008 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004009 N-terminal plug; other site 762376004010 ligand-binding site [chemical binding]; other site 762376004011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 762376004012 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376004013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004014 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 762376004015 putative dimerization interface [polypeptide binding]; other site 762376004016 Sulfatase; Region: Sulfatase; cl10460 762376004017 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376004018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004020 Predicted membrane protein [Function unknown]; Region: COG1971 762376004021 Domain of unknown function DUF; Region: DUF204; pfam02659 762376004022 Domain of unknown function DUF; Region: DUF204; pfam02659 762376004023 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 762376004024 heme-binding site [chemical binding]; other site 762376004025 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 762376004026 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376004027 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376004028 ligand binding site [chemical binding]; other site 762376004029 flexible hinge region; other site 762376004030 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376004031 putative switch regulator; other site 762376004032 non-specific DNA interactions [nucleotide binding]; other site 762376004033 DNA binding site [nucleotide binding] 762376004034 sequence specific DNA binding site [nucleotide binding]; other site 762376004035 putative cAMP binding site [chemical binding]; other site 762376004036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376004037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762376004038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376004039 Walker A/P-loop; other site 762376004040 ATP binding site [chemical binding]; other site 762376004041 Q-loop/lid; other site 762376004042 ABC transporter signature motif; other site 762376004043 Walker B; other site 762376004044 D-loop; other site 762376004045 H-loop/switch region; other site 762376004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 762376004047 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376004048 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004049 N-terminal plug; other site 762376004050 ligand-binding site [chemical binding]; other site 762376004051 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376004052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004053 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376004054 dimerization interface [polypeptide binding]; other site 762376004055 substrate binding pocket [chemical binding]; other site 762376004056 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 762376004057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376004058 catalytic residue [active] 762376004059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004060 D-galactonate transporter; Region: 2A0114; TIGR00893 762376004061 putative substrate translocation pore; other site 762376004062 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376004063 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376004064 MlrC C-terminus; Region: MlrC_C; pfam07171 762376004065 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 762376004066 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 762376004067 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 762376004068 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 762376004069 CGNR zinc finger; Region: zf-CGNR; pfam11706 762376004070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376004071 PAS fold; Region: PAS_3; pfam08447 762376004072 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 762376004073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376004074 metal binding site [ion binding]; metal-binding site 762376004075 active site 762376004076 I-site; other site 762376004077 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762376004078 hydrophobic ligand binding site; other site 762376004079 EamA-like transporter family; Region: EamA; cl01037 762376004080 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376004081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004082 DNA-binding site [nucleotide binding]; DNA binding site 762376004083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376004084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004085 homodimer interface [polypeptide binding]; other site 762376004086 catalytic residue [active] 762376004087 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376004088 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004089 N-terminal plug; other site 762376004090 ligand-binding site [chemical binding]; other site 762376004091 fec operon regulator FecR; Reviewed; Region: PRK09774 762376004092 FecR protein; Region: FecR; pfam04773 762376004093 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376004094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376004096 DNA binding residues [nucleotide binding] 762376004097 fec operon regulator FecR; Reviewed; Region: PRK09774 762376004098 FecR protein; Region: FecR; pfam04773 762376004099 RNA polymerase sigma factor; Provisional; Region: PRK12529 762376004100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376004102 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 762376004103 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 762376004104 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 762376004105 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 762376004106 heme binding pocket [chemical binding]; other site 762376004107 heme ligand [chemical binding]; other site 762376004108 Protein of unknown function (DUF454); Region: DUF454; cl01063 762376004109 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004110 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376004111 Walker A/P-loop; other site 762376004112 ATP binding site [chemical binding]; other site 762376004113 Q-loop/lid; other site 762376004114 ABC transporter signature motif; other site 762376004115 Walker B; other site 762376004116 D-loop; other site 762376004117 H-loop/switch region; other site 762376004118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004119 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376004120 Walker A/P-loop; other site 762376004121 ATP binding site [chemical binding]; other site 762376004122 Q-loop/lid; other site 762376004123 ABC transporter signature motif; other site 762376004124 Walker B; other site 762376004125 D-loop; other site 762376004126 H-loop/switch region; other site 762376004127 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004128 TM-ABC transporter signature motif; other site 762376004129 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004130 TM-ABC transporter signature motif; other site 762376004131 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004132 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376004133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376004134 Beta-lactamase; Region: Beta-lactamase; cl01009 762376004135 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376004136 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 762376004137 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376004138 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376004139 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376004140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 762376004141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004142 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376004143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376004144 dimer interface [polypeptide binding]; other site 762376004145 phosphorylation site [posttranslational modification] 762376004146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376004147 ATP binding site [chemical binding]; other site 762376004148 Mg2+ binding site [ion binding]; other site 762376004149 G-X-G motif; other site 762376004150 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376004151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376004152 active site 762376004153 phosphorylation site [posttranslational modification] 762376004154 intermolecular recognition site; other site 762376004155 dimerization interface [polypeptide binding]; other site 762376004156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376004157 DNA binding site [nucleotide binding] 762376004158 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376004159 Citrate transporter; Region: CitMHS; pfam03600 762376004160 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 762376004161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004162 NAD(P) binding site [chemical binding]; other site 762376004163 active site 762376004164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376004165 non-specific DNA binding site [nucleotide binding]; other site 762376004166 salt bridge; other site 762376004167 sequence-specific DNA binding site [nucleotide binding]; other site 762376004168 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 762376004169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004171 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376004172 Sulfatase; Region: Sulfatase; cl10460 762376004173 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376004174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004176 dimerization interface [polypeptide binding]; other site 762376004177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004179 dimer interface [polypeptide binding]; other site 762376004180 conserved gate region; other site 762376004181 putative PBP binding loops; other site 762376004182 ABC-ATPase subunit interface; other site 762376004183 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376004184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004185 dimer interface [polypeptide binding]; other site 762376004186 conserved gate region; other site 762376004187 putative PBP binding loops; other site 762376004188 ABC-ATPase subunit interface; other site 762376004189 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376004190 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004191 Walker A/P-loop; other site 762376004192 ATP binding site [chemical binding]; other site 762376004193 Q-loop/lid; other site 762376004194 ABC transporter signature motif; other site 762376004195 Walker B; other site 762376004196 D-loop; other site 762376004197 H-loop/switch region; other site 762376004198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004199 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004200 Walker A/P-loop; other site 762376004201 ATP binding site [chemical binding]; other site 762376004202 Q-loop/lid; other site 762376004203 ABC transporter signature motif; other site 762376004204 Walker B; other site 762376004205 D-loop; other site 762376004206 H-loop/switch region; other site 762376004207 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004208 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376004209 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004210 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376004211 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376004212 MlrC C-terminus; Region: MlrC_C; pfam07171 762376004213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004216 dimerization interface [polypeptide binding]; other site 762376004217 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376004218 classical (c) SDRs; Region: SDR_c; cd05233 762376004219 NAD(P) binding site [chemical binding]; other site 762376004220 active site 762376004221 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004223 dimer interface [polypeptide binding]; other site 762376004224 conserved gate region; other site 762376004225 putative PBP binding loops; other site 762376004226 ABC-ATPase subunit interface; other site 762376004227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376004228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004229 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 762376004230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376004231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl02583 762376004232 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 762376004233 putative dimerization interface [polypeptide binding]; other site 762376004234 putative ligand binding site [chemical binding]; other site 762376004235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004236 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376004237 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 762376004238 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 762376004239 NAD binding site [chemical binding]; other site 762376004240 dimerization interface [polypeptide binding]; other site 762376004241 product binding site; other site 762376004242 substrate binding site [chemical binding]; other site 762376004243 zinc binding site [ion binding]; other site 762376004244 catalytic residues [active] 762376004245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376004246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004247 NAD(P) binding site [chemical binding]; other site 762376004248 active site 762376004249 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376004250 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762376004251 NAD(P) binding site [chemical binding]; other site 762376004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004253 dimer interface [polypeptide binding]; other site 762376004254 conserved gate region; other site 762376004255 putative PBP binding loops; other site 762376004256 ABC-ATPase subunit interface; other site 762376004257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004259 dimer interface [polypeptide binding]; other site 762376004260 conserved gate region; other site 762376004261 putative PBP binding loops; other site 762376004262 ABC-ATPase subunit interface; other site 762376004263 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376004264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004265 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376004266 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376004267 Walker A/P-loop; other site 762376004268 ATP binding site [chemical binding]; other site 762376004269 Q-loop/lid; other site 762376004270 ABC transporter signature motif; other site 762376004271 Walker B; other site 762376004272 D-loop; other site 762376004273 H-loop/switch region; other site 762376004274 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376004275 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376004276 tetramer interface [polypeptide binding]; other site 762376004277 TPP-binding site [chemical binding]; other site 762376004278 heterodimer interface [polypeptide binding]; other site 762376004279 phosphorylation loop region [posttranslational modification] 762376004280 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376004281 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376004282 alpha subunit interface [polypeptide binding]; other site 762376004283 TPP binding site [chemical binding]; other site 762376004284 heterodimer interface [polypeptide binding]; other site 762376004285 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376004286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376004287 active site 762376004288 metal binding site [ion binding]; metal-binding site 762376004289 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376004290 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 762376004291 E3 interaction surface; other site 762376004292 lipoyl attachment site [posttranslational modification]; other site 762376004293 e3 binding domain; Region: E3_binding; pfam02817 762376004294 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376004295 DNA-binding site [nucleotide binding]; DNA binding site 762376004296 RNA-binding motif; other site 762376004297 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 762376004298 GAF domain; Region: GAF; cl00853 762376004299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376004300 Walker A motif; other site 762376004301 ATP binding site [chemical binding]; other site 762376004302 Walker B motif; other site 762376004303 arginine finger; other site 762376004304 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 762376004305 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 762376004306 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 762376004307 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 762376004308 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 762376004309 Protein of unknown function (DUF808); Region: DUF808; cl01002 762376004310 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 762376004311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376004313 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376004314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004315 dimer interface [polypeptide binding]; other site 762376004316 conserved gate region; other site 762376004317 putative PBP binding loops; other site 762376004318 ABC-ATPase subunit interface; other site 762376004319 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376004320 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004321 Walker A/P-loop; other site 762376004322 ATP binding site [chemical binding]; other site 762376004323 Q-loop/lid; other site 762376004324 ABC transporter signature motif; other site 762376004325 Walker B; other site 762376004326 D-loop; other site 762376004327 H-loop/switch region; other site 762376004328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004329 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004330 Walker A/P-loop; other site 762376004331 ATP binding site [chemical binding]; other site 762376004332 Q-loop/lid; other site 762376004333 ABC transporter signature motif; other site 762376004334 Walker B; other site 762376004335 D-loop; other site 762376004336 H-loop/switch region; other site 762376004337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004338 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 762376004339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004340 DNA-binding site [nucleotide binding]; DNA binding site 762376004341 FCD domain; Region: FCD; cl11656 762376004342 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004343 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004346 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 762376004347 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376004348 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 762376004349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376004350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004351 DNA-binding site [nucleotide binding]; DNA binding site 762376004352 FCD domain; Region: FCD; cl11656 762376004353 Transposase, Mutator family; Region: Transposase_mut; pfam00872 762376004354 MULE transposase domain; Region: MULE; pfam10551 762376004355 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004356 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004357 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376004358 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376004359 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 762376004360 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376004361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004364 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376004365 NodT family; Region: outer_NodT; TIGR01845 762376004366 Outer membrane efflux protein; Region: OEP; pfam02321 762376004367 Outer membrane efflux protein; Region: OEP; pfam02321 762376004368 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762376004369 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376004370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376004371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004372 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 762376004373 dimer interface [polypeptide binding]; other site 762376004374 metal binding site [ion binding]; metal-binding site 762376004375 choline transport protein BetT; Provisional; Region: PRK09928 762376004376 BCCT family transporter; Region: BCCT; cl00569 762376004377 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376004378 multidrug efflux protein; Reviewed; Region: PRK09579 762376004379 NodT family; Region: outer_NodT; TIGR01845 762376004380 Outer membrane efflux protein; Region: OEP; pfam02321 762376004381 Outer membrane efflux protein; Region: OEP; pfam02321 762376004382 Predicted transcriptional regulator [Transcription]; Region: COG2345 762376004383 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 762376004384 Outer membrane efflux protein; Region: OEP; pfam02321 762376004385 Outer membrane efflux protein; Region: OEP; pfam02321 762376004386 multidrug efflux protein; Reviewed; Region: PRK09577 762376004387 Protein export membrane protein; Region: SecD_SecF; cl14618 762376004388 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376004389 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 762376004390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004391 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 762376004392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376004395 dimerization interface [polypeptide binding]; other site 762376004396 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 762376004397 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004398 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376004399 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376004400 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 762376004401 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762376004402 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376004403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376004404 active site 762376004405 metal binding site [ion binding]; metal-binding site 762376004406 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762376004407 active site 762376004408 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376004409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004410 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376004411 CoenzymeA binding site [chemical binding]; other site 762376004412 subunit interaction site [polypeptide binding]; other site 762376004413 PHB binding site; other site 762376004414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004415 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376004416 trimer interface [polypeptide binding]; other site 762376004417 eyelet of channel; other site 762376004418 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 762376004419 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 762376004420 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 762376004421 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 762376004422 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 762376004423 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 762376004424 putative dimer interface [polypeptide binding]; other site 762376004425 [2Fe-2S] cluster binding site [ion binding]; other site 762376004426 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 762376004427 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 762376004428 SLBB domain; Region: SLBB; pfam10531 762376004429 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 762376004430 NADH dehydrogenase subunit G; Validated; Region: PRK09129 762376004431 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376004432 catalytic loop [active] 762376004433 iron binding site [ion binding]; other site 762376004434 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 762376004435 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions...; Region: MopB_NDH-1_NuoG2; cd02772 762376004436 NADH dehydrogenase; Region: NADHdh; cl00469 762376004437 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 762376004438 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 762376004439 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 762376004440 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 762376004441 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 762376004442 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 762376004443 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 762376004444 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 762376004445 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 762376004446 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 762376004447 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 762376004448 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376004449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004450 N-terminal plug; other site 762376004451 ligand-binding site [chemical binding]; other site 762376004452 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 762376004453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376004454 motif II; other site 762376004455 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762376004456 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 762376004457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376004458 ATP binding site [chemical binding]; other site 762376004459 putative Mg++ binding site [ion binding]; other site 762376004460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376004461 nucleotide binding region [chemical binding]; other site 762376004462 ATP-binding site [chemical binding]; other site 762376004463 TRCF domain; Region: TRCF; pfam03461 762376004464 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 762376004465 substrate binding site [chemical binding]; other site 762376004466 dimer interface [polypeptide binding]; other site 762376004467 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 762376004468 homotrimer interaction site [polypeptide binding]; other site 762376004469 zinc binding site [ion binding]; other site 762376004470 CDP-binding sites; other site 762376004471 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376004472 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 762376004473 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376004474 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376004475 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 762376004476 dimer interface [polypeptide binding]; other site 762376004477 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762376004478 catalytic triad [active] 762376004479 peroxidatic and resolving cysteines [active] 762376004480 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376004481 dimerization interface [polypeptide binding]; other site 762376004482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 762376004483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 762376004484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376004485 ATP binding site [chemical binding]; other site 762376004486 Mg2+ binding site [ion binding]; other site 762376004487 G-X-G motif; other site 762376004488 osmolarity response regulator; Provisional; Region: ompR; PRK09468 762376004489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376004490 active site 762376004491 phosphorylation site [posttranslational modification] 762376004492 intermolecular recognition site; other site 762376004493 dimerization interface [polypeptide binding]; other site 762376004494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376004495 DNA binding site [nucleotide binding] 762376004496 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 762376004497 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762376004498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376004499 Coenzyme A binding pocket [chemical binding]; other site 762376004500 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 762376004501 lysophospholipid transporter LplT; Provisional; Region: PRK11195 762376004502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004503 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376004504 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 762376004505 Walker A/P-loop; other site 762376004506 ATP binding site [chemical binding]; other site 762376004507 Q-loop/lid; other site 762376004508 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 762376004509 ABC transporter signature motif; other site 762376004510 Walker B; other site 762376004511 D-loop; other site 762376004512 H-loop/switch region; other site 762376004513 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 762376004514 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762376004515 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762376004516 nucleotide binding pocket [chemical binding]; other site 762376004517 K-X-D-G motif; other site 762376004518 catalytic site [active] 762376004519 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762376004520 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762376004521 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 762376004522 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 762376004523 Dimer interface [polypeptide binding]; other site 762376004524 BRCT sequence motif; other site 762376004525 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376004526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004527 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376004528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004530 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376004531 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376004532 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 762376004533 active site 762376004534 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376004535 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 762376004536 active site 762376004537 iron coordination sites [ion binding]; other site 762376004538 substrate binding pocket [chemical binding]; other site 762376004539 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 762376004540 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376004541 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 762376004542 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376004543 BolA-like protein; Region: BolA; cl00386 762376004544 Intracellular septation protein A; Region: IspA; cl01098 762376004545 SelR domain; Region: SelR; cl00369 762376004546 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762376004547 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762376004548 Walker A/P-loop; other site 762376004549 ATP binding site [chemical binding]; other site 762376004550 Q-loop/lid; other site 762376004551 ABC transporter signature motif; other site 762376004552 Walker B; other site 762376004553 D-loop; other site 762376004554 H-loop/switch region; other site 762376004555 Cobalt transport protein; Region: CbiQ; cl00463 762376004556 BioY family; Region: BioY; cl00560 762376004557 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004558 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376004559 putative ligand binding site [chemical binding]; other site 762376004560 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 762376004561 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004562 TM-ABC transporter signature motif; other site 762376004563 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004564 TM-ABC transporter signature motif; other site 762376004565 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004566 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376004567 Walker A/P-loop; other site 762376004568 ATP binding site [chemical binding]; other site 762376004569 Q-loop/lid; other site 762376004570 ABC transporter signature motif; other site 762376004571 Walker B; other site 762376004572 D-loop; other site 762376004573 H-loop/switch region; other site 762376004574 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004575 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376004576 Walker A/P-loop; other site 762376004577 ATP binding site [chemical binding]; other site 762376004578 Q-loop/lid; other site 762376004579 ABC transporter signature motif; other site 762376004580 Walker B; other site 762376004581 D-loop; other site 762376004582 H-loop/switch region; other site 762376004583 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 762376004584 Pseudomonas-type; Region: PC_PLC; TIGR03396 762376004585 Phosphoesterase family; Region: Phosphoesterase; cl10627 762376004586 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004587 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004588 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 762376004589 homodimer interface [polypeptide binding]; other site 762376004590 substrate-cofactor binding pocket; other site 762376004591 Aminotransferase class IV; Region: Aminotran_4; pfam01063 762376004592 catalytic residue [active] 762376004593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004594 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762376004595 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004596 TM-ABC transporter signature motif; other site 762376004597 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004598 TM-ABC transporter signature motif; other site 762376004599 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004600 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376004601 putative ligand binding site [chemical binding]; other site 762376004602 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004603 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376004604 Walker A/P-loop; other site 762376004605 ATP binding site [chemical binding]; other site 762376004606 Q-loop/lid; other site 762376004607 ABC transporter signature motif; other site 762376004608 Walker B; other site 762376004609 D-loop; other site 762376004610 H-loop/switch region; other site 762376004611 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004612 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376004613 Walker A/P-loop; other site 762376004614 ATP binding site [chemical binding]; other site 762376004615 Q-loop/lid; other site 762376004616 ABC transporter signature motif; other site 762376004617 Walker B; other site 762376004618 D-loop; other site 762376004619 H-loop/switch region; other site 762376004620 endonuclease III; Provisional; Region: PRK10702 762376004621 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376004622 minor groove reading motif; other site 762376004623 helix-hairpin-helix signature motif; other site 762376004624 substrate binding pocket [chemical binding]; other site 762376004625 active site 762376004626 FES domain; Region: FES; smart00525 762376004627 ferredoxin; Provisional; Region: PRK06991 762376004628 Putative Fe-S cluster; Region: FeS; pfam04060 762376004629 4Fe-4S binding domain; Region: Fer4; cl02805 762376004630 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 762376004631 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 762376004632 ferredoxin-NADP reductase; Provisional; Region: PRK10926 762376004633 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 762376004634 FAD binding pocket [chemical binding]; other site 762376004635 FAD binding motif [chemical binding]; other site 762376004636 phosphate binding motif [ion binding]; other site 762376004637 beta-alpha-beta structure motif; other site 762376004638 NAD binding pocket [chemical binding]; other site 762376004639 Ferredoxin [Energy production and conversion]; Region: COG1146 762376004640 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 762376004641 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 762376004642 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401 762376004643 active site 762376004644 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 762376004645 homotrimer interaction site [polypeptide binding]; other site 762376004646 putative active site [active] 762376004647 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376004648 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 762376004649 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762376004650 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762376004651 synthetase active site [active] 762376004652 NTP binding site [chemical binding]; other site 762376004653 metal binding site [ion binding]; metal-binding site 762376004654 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 762376004655 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762376004656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004657 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376004658 putative substrate translocation pore; other site 762376004659 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376004660 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 762376004661 metal binding site [ion binding]; metal-binding site 762376004662 putative dimer interface [polypeptide binding]; other site 762376004663 tryptophan synthase, beta chain; Region: PLN02618 762376004664 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762376004665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004666 catalytic residue [active] 762376004667 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 762376004668 substrate binding site [chemical binding]; other site 762376004669 active site 762376004670 catalytic residues [active] 762376004671 heterodimer interface [polypeptide binding]; other site 762376004672 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762376004673 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376004674 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 762376004675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004677 galactarate dehydratase; Region: galactar-dH20; TIGR03248 762376004678 SAF domain; Region: SAF; cl00555 762376004679 SAF domain; Region: SAF; cl00555 762376004680 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376004681 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376004682 inhibitor site; inhibition site 762376004683 active site 762376004684 dimer interface [polypeptide binding]; other site 762376004685 catalytic residue [active] 762376004686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004688 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376004689 putative dimerization interface [polypeptide binding]; other site 762376004690 ribonuclease E; Reviewed; Region: rne; PRK10811 762376004691 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762376004692 homodimer interface [polypeptide binding]; other site 762376004693 oligonucleotide binding site [chemical binding]; other site 762376004694 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 762376004695 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762376004696 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 762376004697 active site 762376004698 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376004699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376004700 motif II; other site 762376004701 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 762376004702 Moco binding site; other site 762376004703 metal coordination site [ion binding]; other site 762376004704 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 762376004705 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 762376004706 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762376004707 amidase catalytic site [active] 762376004708 Zn binding residues [ion binding]; other site 762376004709 substrate binding site [chemical binding]; other site 762376004710 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376004711 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 762376004712 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762376004713 active site 762376004714 dimer interface [polypeptide binding]; other site 762376004715 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 762376004716 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 762376004717 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376004718 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762376004719 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762376004720 dimer interface [polypeptide binding]; other site 762376004721 active site 762376004722 CoA binding pocket [chemical binding]; other site 762376004723 Acyl transferase domain; Region: Acyl_transf_1; cl08282 762376004724 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762376004725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004726 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376004727 NAD(P) binding site [chemical binding]; other site 762376004728 active site 762376004729 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376004730 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 762376004731 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762376004732 dimer interface [polypeptide binding]; other site 762376004733 active site 762376004734 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 762376004735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376004737 DNA binding residues [nucleotide binding] 762376004738 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 762376004739 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 762376004740 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762376004741 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 762376004742 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762376004743 protein binding site [polypeptide binding]; other site 762376004744 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762376004745 GTP-binding protein LepA; Provisional; Region: PRK05433 762376004746 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 762376004747 G1 box; other site 762376004748 putative GEF interaction site [polypeptide binding]; other site 762376004749 GTP/Mg2+ binding site [chemical binding]; other site 762376004750 Switch I region; other site 762376004751 G2 box; other site 762376004752 G3 box; other site 762376004753 Switch II region; other site 762376004754 G4 box; other site 762376004755 G5 box; other site 762376004756 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 762376004757 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762376004758 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762376004759 signal peptidase I; Provisional; Region: PRK10861 762376004760 HemY protein N-terminus; Region: HemY_N; pfam07219 762376004761 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762376004762 Catalytic site [active] 762376004763 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762376004764 ribonuclease III; Reviewed; Region: rnc; PRK00102 762376004765 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 762376004766 dimerization interface [polypeptide binding]; other site 762376004767 active site 762376004768 metal binding site [ion binding]; metal-binding site 762376004769 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 762376004770 dsRNA binding site [nucleotide binding]; other site 762376004771 GTPase Era; Reviewed; Region: era; PRK00089 762376004772 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 762376004773 G1 box; other site 762376004774 GTP/Mg2+ binding site [chemical binding]; other site 762376004775 Switch I region; other site 762376004776 G2 box; other site 762376004777 Switch II region; other site 762376004778 G3 box; other site 762376004779 G4 box; other site 762376004780 G5 box; other site 762376004781 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 762376004782 Recombination protein O N terminal; Region: RecO_N; pfam11967 762376004783 Recombination protein O C terminal; Region: RecO_C; pfam02565 762376004784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004786 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376004787 putative dimerization interface [polypeptide binding]; other site 762376004788 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 762376004789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376004790 catalytic residue [active] 762376004791 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 762376004792 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 762376004793 active site 762376004794 Zn-binding site [ion binding]; other site 762376004795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376004796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004797 TLC ATP/ADP transporter; Region: TLC; cl03940 762376004798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376004799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376004800 active site 762376004801 catalytic tetrad [active] 762376004802 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 762376004803 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 762376004804 multifunctional aminopeptidase A; Provisional; Region: PRK00913 762376004805 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 762376004806 interface (dimer of trimers) [polypeptide binding]; other site 762376004807 Substrate-binding/catalytic site; other site 762376004808 Zn-binding sites [ion binding]; other site 762376004809 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 762376004810 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762376004811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004814 dimerization interface [polypeptide binding]; other site 762376004815 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004816 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376004817 putative ligand binding site [chemical binding]; other site 762376004818 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376004819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376004820 tetrameric interface [polypeptide binding]; other site 762376004821 NAD binding site [chemical binding]; other site 762376004822 catalytic residues [active] 762376004823 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 762376004824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376004825 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 762376004826 substrate binding site [chemical binding]; other site 762376004827 dimerization interface [polypeptide binding]; other site 762376004828 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 762376004829 NlpC/P60 family; Region: NLPC_P60; cl11438 762376004830 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 762376004831 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 762376004832 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376004833 Domain of unknown function (DUF336); Region: DUF336; cl01249 762376004834 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 762376004835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004836 putative substrate translocation pore; other site 762376004837 acetyl-CoA synthetase; Provisional; Region: PRK00174 762376004838 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 762376004839 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376004840 EamA-like transporter family; Region: EamA; cl01037 762376004841 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376004842 EamA-like transporter family; Region: EamA; cl01037 762376004843 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 762376004844 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762376004845 tetramer interface [polypeptide binding]; other site 762376004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004847 catalytic residue [active] 762376004848 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 762376004849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376004850 inhibitor-cofactor binding pocket; inhibition site 762376004851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004852 catalytic residue [active] 762376004853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004854 DNA-binding site [nucleotide binding]; DNA binding site 762376004855 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376004856 FCD domain; Region: FCD; cl11656 762376004857 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376004858 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762376004859 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004862 dimer interface [polypeptide binding]; other site 762376004863 conserved gate region; other site 762376004864 putative PBP binding loops; other site 762376004865 ABC-ATPase subunit interface; other site 762376004866 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376004867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004868 dimer interface [polypeptide binding]; other site 762376004869 conserved gate region; other site 762376004870 putative PBP binding loops; other site 762376004871 ABC-ATPase subunit interface; other site 762376004872 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376004873 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004874 Walker A/P-loop; other site 762376004875 ATP binding site [chemical binding]; other site 762376004876 Q-loop/lid; other site 762376004877 ABC transporter signature motif; other site 762376004878 Walker B; other site 762376004879 D-loop; other site 762376004880 H-loop/switch region; other site 762376004881 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004882 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004883 Walker A/P-loop; other site 762376004884 ATP binding site [chemical binding]; other site 762376004885 Q-loop/lid; other site 762376004886 ABC transporter signature motif; other site 762376004887 Walker B; other site 762376004888 D-loop; other site 762376004889 H-loop/switch region; other site 762376004890 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004891 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 762376004892 Cytochrome P450; Region: p450; cl12078 762376004893 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 762376004894 TIGR01777 family protein; Region: yfcH 762376004895 putative NAD(P) binding site [chemical binding]; other site 762376004896 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 762376004897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376004898 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 762376004899 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376004900 active site 762376004901 Coenzyme A transferase; Region: CoA_trans; cl00773 762376004902 Coenzyme A transferase; Region: CoA_trans; cl00773 762376004903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376004904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376004905 Coenzyme A binding pocket [chemical binding]; other site 762376004906 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376004907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376004908 putative active site [active] 762376004909 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512 762376004910 active site 762376004911 dimer interface [polypeptide binding]; other site 762376004912 catalytic nucleophile [active] 762376004913 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376004914 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004915 Walker A/P-loop; other site 762376004916 ATP binding site [chemical binding]; other site 762376004917 Q-loop/lid; other site 762376004918 ABC transporter signature motif; other site 762376004919 Walker B; other site 762376004920 D-loop; other site 762376004921 H-loop/switch region; other site 762376004922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004923 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376004924 Walker A/P-loop; other site 762376004925 ATP binding site [chemical binding]; other site 762376004926 Q-loop/lid; other site 762376004927 ABC transporter signature motif; other site 762376004928 Walker B; other site 762376004929 D-loop; other site 762376004930 H-loop/switch region; other site 762376004931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004932 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 762376004933 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 762376004934 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 762376004935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004936 dimer interface [polypeptide binding]; other site 762376004937 conserved gate region; other site 762376004938 putative PBP binding loops; other site 762376004939 ABC-ATPase subunit interface; other site 762376004940 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 762376004941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376004942 dimer interface [polypeptide binding]; other site 762376004943 conserved gate region; other site 762376004944 putative PBP binding loops; other site 762376004945 ABC-ATPase subunit interface; other site 762376004946 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 762376004947 homodimer interface [polypeptide binding]; other site 762376004948 homotetramer interface [polypeptide binding]; other site 762376004949 active site pocket [active] 762376004950 cleavage site 762376004951 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 762376004952 SxDxEG motif; other site 762376004953 active site 762376004954 metal binding site [ion binding]; metal-binding site 762376004955 homopentamer interface [polypeptide binding]; other site 762376004956 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376004957 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376004958 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 762376004959 active site 762376004960 CTP synthetase; Validated; Region: pyrG; PRK05380 762376004961 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 762376004962 Catalytic site [active] 762376004963 Active site [active] 762376004964 UTP binding site [chemical binding]; other site 762376004965 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762376004966 active site 762376004967 putative oxyanion hole; other site 762376004968 catalytic triad [active] 762376004969 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 762376004970 enolase; Provisional; Region: eno; PRK00077 762376004971 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762376004972 dimer interface [polypeptide binding]; other site 762376004973 metal binding site [ion binding]; metal-binding site 762376004974 substrate binding pocket [chemical binding]; other site 762376004975 Septum formation initiator; Region: DivIC; cl11433 762376004976 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 762376004977 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 762376004978 dimerization interface [polypeptide binding]; other site 762376004979 domain crossover interface; other site 762376004980 redox-dependent activation switch; other site 762376004981 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 762376004982 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 762376004983 trimer interface [polypeptide binding]; other site 762376004984 putative metal binding site [ion binding]; other site 762376004985 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376004986 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376004987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376004988 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 762376004989 putative active site [active] 762376004990 putative metal binding site [ion binding]; other site 762376004991 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 762376004992 RDD family; Region: RDD; cl00746 762376004993 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 762376004994 THUMP domain; Region: THUMP; cl12076 762376004995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376004996 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 762376004997 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376004998 2-methylcitrate dehydratase; Region: prpD; TIGR02330 762376004999 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376005000 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (...; Region: Ec2MCS_like_1; cd06117 762376005001 dimer interface [polypeptide binding]; other site 762376005002 active site 762376005003 citrylCoA binding site [chemical binding]; other site 762376005004 oxalacetate/citrate binding site [chemical binding]; other site 762376005005 coenzyme A binding site [chemical binding]; other site 762376005006 catalytic triad [active] 762376005007 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376005008 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376005009 tetramer interface [polypeptide binding]; other site 762376005010 active site 762376005011 Mg2+/Mn2+ binding site [ion binding]; other site 762376005012 malate dehydrogenase; Provisional; Region: PRK05442 762376005013 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 762376005014 NAD(P) binding site [chemical binding]; other site 762376005015 dimer interface [polypeptide binding]; other site 762376005016 malate binding site [chemical binding]; other site 762376005017 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376005018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376005019 DNA-binding site [nucleotide binding]; DNA binding site 762376005020 UTRA domain; Region: UTRA; cl06649 762376005021 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 762376005022 Iron-sulfur protein interface; other site 762376005023 proximal quinone binding site [chemical binding]; other site 762376005024 SdhD (CybS) interface [polypeptide binding]; other site 762376005025 proximal heme binding site [chemical binding]; other site 762376005026 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 762376005027 SdhC subunit interface [polypeptide binding]; other site 762376005028 proximal heme binding site [chemical binding]; other site 762376005029 cardiolipin binding site; other site 762376005030 Iron-sulfur protein interface; other site 762376005031 proximal quinone binding site [chemical binding]; other site 762376005032 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 762376005033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376005034 domain; Region: Succ_DH_flav_C; pfam02910 762376005035 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 762376005036 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 762376005037 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 762376005038 dimer interface [polypeptide binding]; other site 762376005039 Citrate synthase; Region: Citrate_synt; pfam00285 762376005040 active site 762376005041 citrylCoA binding site [chemical binding]; other site 762376005042 NADH binding [chemical binding]; other site 762376005043 cationic pore residues; other site 762376005044 oxalacetate/citrate binding site [chemical binding]; other site 762376005045 coenzyme A binding site [chemical binding]; other site 762376005046 catalytic triad [active] 762376005047 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 762376005048 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 762376005049 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376005050 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376005051 putative NAD(P) binding site [chemical binding]; other site 762376005052 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376005053 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 762376005054 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376005055 dimer interface [polypeptide binding]; other site 762376005056 TPP-binding site [chemical binding]; other site 762376005057 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 762376005058 OPT oligopeptide transporter protein; Region: OPT; cl14607 762376005059 putative oligopeptide transporter, OPT family; Region: TIGR00733 762376005060 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 762376005061 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 762376005062 putative metal binding site [ion binding]; other site 762376005063 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 762376005064 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 762376005065 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376005066 active site 762376005067 metal binding site [ion binding]; metal-binding site 762376005068 dimer interface [polypeptide binding]; other site 762376005069 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 762376005070 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376005071 D-cysteine desulfhydrase; Validated; Region: PRK03910 762376005072 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 762376005073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005074 catalytic residue [active] 762376005075 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 762376005076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005077 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 762376005078 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 762376005079 TPP-binding site [chemical binding]; other site 762376005080 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 762376005081 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 762376005082 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376005083 E3 interaction surface; other site 762376005084 lipoyl attachment site [posttranslational modification]; other site 762376005085 e3 binding domain; Region: E3_binding; pfam02817 762376005086 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762376005087 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 762376005088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376005089 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376005090 Predicted ATPase [General function prediction only]; Region: COG1485 762376005091 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376005092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376005093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376005094 DNA binding residues [nucleotide binding] 762376005095 fec operon regulator FecR; Reviewed; Region: PRK09774 762376005096 FecR protein; Region: FecR; pfam04773 762376005097 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376005098 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376005099 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376005100 N-terminal plug; other site 762376005101 ligand-binding site [chemical binding]; other site 762376005102 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 762376005103 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376005104 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 762376005105 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 762376005106 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762376005107 active site 762376005108 HIGH motif; other site 762376005109 dimer interface [polypeptide binding]; other site 762376005110 KMSKS motif; other site 762376005111 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762376005112 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762376005113 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 762376005114 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 762376005115 RNA binding site [nucleotide binding]; other site 762376005116 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762376005117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 762376005118 ATP binding site [chemical binding]; other site 762376005119 DEAD_2; Region: DEAD_2; cl14887 762376005120 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 762376005121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005122 putative substrate translocation pore; other site 762376005123 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376005124 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376005125 conserved cys residue [active] 762376005126 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 762376005127 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 762376005128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376005129 RNA binding surface [nucleotide binding]; other site 762376005130 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 762376005131 active site 762376005132 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 762376005133 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 762376005134 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 762376005135 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 762376005136 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 762376005137 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376005138 NAD(P) binding site [chemical binding]; other site 762376005139 homotetramer interface [polypeptide binding]; other site 762376005140 homodimer interface [polypeptide binding]; other site 762376005141 active site 762376005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 762376005143 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 762376005144 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 762376005145 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 762376005146 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 762376005147 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 762376005148 Fe2+ transport protein; Region: Iron_transport; cl01377 762376005149 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376005150 Iron permease FTR1 family; Region: FTR1; cl00475 762376005151 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 762376005152 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376005153 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376005154 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762376005155 BON domain; Region: BON; cl02771 762376005156 CsbD-like; Region: CsbD; cl01272 762376005157 cyanophycin synthetase; Provisional; Region: PRK14016 762376005158 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376005159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376005160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376005161 cyanophycin synthetase; Provisional; Region: PRK14016 762376005162 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376005163 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376005164 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376005165 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376005166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376005167 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 762376005168 Walker A/P-loop; other site 762376005169 ATP binding site [chemical binding]; other site 762376005170 Q-loop/lid; other site 762376005171 ABC transporter signature motif; other site 762376005172 Walker B; other site 762376005173 D-loop; other site 762376005174 H-loop/switch region; other site 762376005175 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 762376005176 FemAB family; Region: FemAB; cl11444 762376005177 Protein of unknown function, DUF482; Region: DUF482; pfam04339 762376005178 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376005179 dinuclear metal binding motif [ion binding]; other site 762376005180 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376005181 lytic murein transglycosylase; Region: MltB_2; TIGR02283 762376005182 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376005183 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 762376005184 hypothetical protein; Provisional; Region: PRK09936 762376005185 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 762376005186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762376005187 active site 762376005188 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 762376005189 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 762376005190 active site 762376005191 homodimer interface [polypeptide binding]; other site 762376005192 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376005193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376005194 substrate binding site [chemical binding]; other site 762376005195 oxyanion hole (OAH) forming residues; other site 762376005196 trimer interface [polypeptide binding]; other site 762376005197 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376005198 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005199 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376005200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376005201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005202 active site 762376005203 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376005204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005205 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376005206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376005207 active site 2 [active] 762376005208 active site 1 [active] 762376005209 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376005210 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376005211 NAD(P) binding site [chemical binding]; other site 762376005212 homotetramer interface [polypeptide binding]; other site 762376005213 homodimer interface [polypeptide binding]; other site 762376005214 active site 762376005215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005219 enoyl-CoA hydratase; Region: PLN02864 762376005220 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376005221 dimer interaction site [polypeptide binding]; other site 762376005222 substrate-binding tunnel; other site 762376005223 active site 762376005224 catalytic site [active] 762376005225 substrate binding site [chemical binding]; other site 762376005226 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376005227 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376005228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376005229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005230 active site 762376005231 thiolase; Provisional; Region: PRK06158 762376005232 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376005233 active site 762376005234 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376005235 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376005236 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005238 putative substrate translocation pore; other site 762376005239 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376005240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376005241 motif II; other site 762376005242 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 762376005243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376005244 S-adenosylmethionine binding site [chemical binding]; other site 762376005245 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376005246 ligand binding site [chemical binding]; other site 762376005247 DNA gyrase subunit A; Validated; Region: PRK05560 762376005248 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 762376005249 CAP-like domain; other site 762376005250 Active site [active] 762376005251 primary dimer interface [polypeptide binding]; other site 762376005252 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005253 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005254 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005255 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005256 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005257 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005258 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 762376005259 homodimer interface [polypeptide binding]; other site 762376005260 substrate-cofactor binding pocket; other site 762376005261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005262 catalytic residue [active] 762376005263 Chorismate mutase type II; Region: CM_2; cl00693 762376005264 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 762376005265 Prephenate dehydratase; Region: PDT; pfam00800 762376005266 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 762376005267 putative L-Phe binding site [chemical binding]; other site 762376005268 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 762376005269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005271 homodimer interface [polypeptide binding]; other site 762376005272 catalytic residue [active] 762376005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005274 Prephenate dehydrogenase; Region: PDH; pfam02153 762376005275 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762376005276 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 762376005277 hinge; other site 762376005278 active site 762376005279 cytidylate kinase; Provisional; Region: cmk; PRK00023 762376005280 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762376005281 CMP-binding site; other site 762376005282 The sites determining sugar specificity; other site 762376005283 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 762376005284 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762376005285 RNA binding site [nucleotide binding]; other site 762376005286 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762376005287 RNA binding site [nucleotide binding]; other site 762376005288 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 762376005289 RNA binding site [nucleotide binding]; other site 762376005290 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 762376005291 RNA binding site [nucleotide binding]; other site 762376005292 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 762376005293 RNA binding site [nucleotide binding]; other site 762376005294 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 762376005295 RNA binding site [nucleotide binding]; other site 762376005296 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 762376005297 IHF dimer interface [polypeptide binding]; other site 762376005298 IHF - DNA interface [nucleotide binding]; other site 762376005299 tetratricopeptide repeat protein; Provisional; Region: PRK11788 762376005300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376005301 binding surface 762376005302 TPR motif; other site 762376005303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376005304 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 762376005305 putative ribose interaction site [chemical binding]; other site 762376005306 putative ADP binding site [chemical binding]; other site 762376005307 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 762376005308 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 762376005309 NADP binding site [chemical binding]; other site 762376005310 homopentamer interface [polypeptide binding]; other site 762376005311 substrate binding site [chemical binding]; other site 762376005312 active site 762376005313 Protein of unknown function, DUF655; Region: DUF655; cl00648 762376005314 cysteine synthases; Region: cysKM; TIGR01136 762376005315 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 762376005316 dimer interface [polypeptide binding]; other site 762376005317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005318 catalytic residue [active] 762376005319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005321 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005323 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376005324 Putative cyclase; Region: Cyclase; cl00814 762376005325 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376005326 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762376005327 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 762376005328 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376005329 Ligand binding site [chemical binding]; other site 762376005330 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 762376005331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376005332 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376005333 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 762376005334 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 762376005335 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376005336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376005337 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 762376005338 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 762376005339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005341 homodimer interface [polypeptide binding]; other site 762376005342 catalytic residue [active] 762376005343 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 762376005344 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 762376005345 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376005346 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376005347 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 762376005348 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 762376005349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005350 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376005351 putative dimerization interface [polypeptide binding]; other site 762376005352 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376005353 enoyl-CoA hydratase; Provisional; Region: PRK06144 762376005354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376005355 substrate binding site [chemical binding]; other site 762376005356 oxyanion hole (OAH) forming residues; other site 762376005357 trimer interface [polypeptide binding]; other site 762376005358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005360 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 762376005361 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 762376005362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005363 active site 762376005364 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376005365 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376005366 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 762376005367 dimer interface [polypeptide binding]; other site 762376005368 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762376005369 catalytic triad [active] 762376005370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005371 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762376005372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376005373 dimer interface [polypeptide binding]; other site 762376005374 conserved gate region; other site 762376005375 putative PBP binding loops; other site 762376005376 ABC-ATPase subunit interface; other site 762376005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376005378 dimer interface [polypeptide binding]; other site 762376005379 conserved gate region; other site 762376005380 putative PBP binding loops; other site 762376005381 ABC-ATPase subunit interface; other site 762376005382 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 762376005383 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 762376005384 Walker A/P-loop; other site 762376005385 ATP binding site [chemical binding]; other site 762376005386 Q-loop/lid; other site 762376005387 ABC transporter signature motif; other site 762376005388 Walker B; other site 762376005389 D-loop; other site 762376005390 H-loop/switch region; other site 762376005391 TOBE-like domain; Region: TOBE_3; pfam12857 762376005392 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762376005393 Active Sites [active] 762376005394 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 762376005395 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762376005396 Active Sites [active] 762376005397 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 762376005398 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 762376005399 CysD dimerization site [polypeptide binding]; other site 762376005400 G1 box; other site 762376005401 putative GEF interaction site [polypeptide binding]; other site 762376005402 GTP/Mg2+ binding site [chemical binding]; other site 762376005403 Switch I region; other site 762376005404 G2 box; other site 762376005405 G3 box; other site 762376005406 Switch II region; other site 762376005407 G4 box; other site 762376005408 G5 box; other site 762376005409 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 762376005410 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 762376005411 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 762376005412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376005413 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 762376005414 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 762376005415 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 762376005416 putative active site [active] 762376005417 putative CoA binding site [chemical binding]; other site 762376005418 nudix motif; other site 762376005419 metal binding site [ion binding]; metal-binding site 762376005420 GTPase RsgA; Reviewed; Region: PRK00098 762376005421 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 762376005422 GTPase/OB domain interface [polypeptide binding]; other site 762376005423 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762376005424 GTP/Mg2+ binding site [chemical binding]; other site 762376005425 G4 box; other site 762376005426 G5 box; other site 762376005427 G1 box; other site 762376005428 Switch I region; other site 762376005429 G2 box; other site 762376005430 G3 box; other site 762376005431 Switch II region; other site 762376005432 Peptidase family M48; Region: Peptidase_M48; cl12018 762376005433 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 762376005434 putative active site [active] 762376005435 putative substrate binding site [chemical binding]; other site 762376005436 catalytic site [active] 762376005437 dimer interface [polypeptide binding]; other site 762376005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376005439 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762376005440 Walker A motif; other site 762376005441 ATP binding site [chemical binding]; other site 762376005442 Walker B motif; other site 762376005443 arginine finger; other site 762376005444 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376005445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005446 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376005447 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 762376005448 PaaX-like protein; Region: PaaX; pfam07848 762376005449 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 762376005450 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 762376005451 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 762376005452 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 762376005453 Phenylacetic acid degradation B; Region: PaaB; cl01371 762376005454 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 762376005455 Domain of unknown function DUF59; Region: DUF59; cl00941 762376005456 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 762376005457 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 762376005458 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 762376005459 FAD binding pocket [chemical binding]; other site 762376005460 FAD binding motif [chemical binding]; other site 762376005461 phosphate binding motif [ion binding]; other site 762376005462 beta-alpha-beta structure motif; other site 762376005463 NAD(p) ribose binding residues [chemical binding]; other site 762376005464 NAD binding pocket [chemical binding]; other site 762376005465 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 762376005466 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376005467 catalytic loop [active] 762376005468 iron binding site [ion binding]; other site 762376005469 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 762376005470 NADP binding site [chemical binding]; other site 762376005471 catalytic residues [active] 762376005472 enoyl-CoA hydratase; Provisional; Region: PRK08140 762376005473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376005474 substrate binding site [chemical binding]; other site 762376005475 oxyanion hole (OAH) forming residues; other site 762376005476 trimer interface [polypeptide binding]; other site 762376005477 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376005478 CoenzymeA binding site [chemical binding]; other site 762376005479 subunit interaction site [polypeptide binding]; other site 762376005480 PHB binding site; other site 762376005481 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376005482 multidrug efflux protein; Reviewed; Region: PRK01766 762376005483 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376005484 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 762376005485 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 762376005486 Putative cyclase; Region: Cyclase; cl00814 762376005487 hypothetical protein; Reviewed; Region: PRK00024 762376005488 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762376005489 MPN+ (JAMM) motif; other site 762376005490 Zinc-binding site [ion binding]; other site 762376005491 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 762376005492 LytB protein; Region: LYTB; cl00507 762376005493 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 762376005494 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 762376005495 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376005496 C-terminal domain interface [polypeptide binding]; other site 762376005497 GSH binding site (G-site) [chemical binding]; other site 762376005498 putative dimer interface [polypeptide binding]; other site 762376005499 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 762376005500 dimer interface [polypeptide binding]; other site 762376005501 N-terminal domain interface [polypeptide binding]; other site 762376005502 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 762376005503 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762376005504 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 762376005505 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762376005506 protein binding site [polypeptide binding]; other site 762376005507 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762376005508 protein binding site [polypeptide binding]; other site 762376005509 sensor protein QseC; Provisional; Region: PRK10337 762376005510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376005511 dimer interface [polypeptide binding]; other site 762376005512 phosphorylation site [posttranslational modification] 762376005513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376005514 ATP binding site [chemical binding]; other site 762376005515 Mg2+ binding site [ion binding]; other site 762376005516 G-X-G motif; other site 762376005517 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 762376005518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376005519 active site 762376005520 phosphorylation site [posttranslational modification] 762376005521 intermolecular recognition site; other site 762376005522 dimerization interface [polypeptide binding]; other site 762376005523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376005524 DNA binding site [nucleotide binding] 762376005525 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376005526 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376005527 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 762376005528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005529 transcriptional activator TtdR; Provisional; Region: PRK09801 762376005530 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376005531 putative effector binding pocket; other site 762376005532 dimerization interface [polypeptide binding]; other site 762376005533 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 762376005534 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376005535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376005536 RNA binding surface [nucleotide binding]; other site 762376005537 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 762376005538 probable active site [active] 762376005539 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762376005540 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 762376005541 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 762376005542 Sm1 motif; other site 762376005543 D3 - B interaction site; other site 762376005544 D1 - D2 interaction site; other site 762376005545 Hfq - Hfq interaction site; other site 762376005546 RNA binding pocket [nucleotide binding]; other site 762376005547 Sm2 motif; other site 762376005548 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 762376005549 NusA N-terminal domain; Region: NusA_N; pfam08529 762376005550 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 762376005551 RNA binding site [nucleotide binding]; other site 762376005552 homodimer interface [polypeptide binding]; other site 762376005553 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762376005554 G-X-X-G motif; other site 762376005555 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 762376005556 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 762376005557 translation initiation factor IF-2; Validated; Region: infB; PRK05306 762376005558 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 762376005559 translation initiation factor IF-2; Region: IF-2; TIGR00487 762376005560 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762376005561 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 762376005562 G1 box; other site 762376005563 putative GEF interaction site [polypeptide binding]; other site 762376005564 GTP/Mg2+ binding site [chemical binding]; other site 762376005565 Switch I region; other site 762376005566 G2 box; other site 762376005567 G3 box; other site 762376005568 Switch II region; other site 762376005569 G4 box; other site 762376005570 G5 box; other site 762376005571 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 762376005572 Translation-initiation factor 2; Region: IF-2; pfam11987 762376005573 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 762376005574 Ribosome-binding factor A; Region: RBFA; cl00542 762376005575 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 762376005576 RNA binding site [nucleotide binding]; other site 762376005577 active site 762376005578 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 762376005579 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 762376005580 G1 box; other site 762376005581 putative GEF interaction site [polypeptide binding]; other site 762376005582 GTP/Mg2+ binding site [chemical binding]; other site 762376005583 Switch I region; other site 762376005584 G2 box; other site 762376005585 G3 box; other site 762376005586 Switch II region; other site 762376005587 G4 box; other site 762376005588 G5 box; other site 762376005589 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762376005590 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 762376005591 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376005592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376005594 dimerization interface [polypeptide binding]; other site 762376005595 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 762376005596 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-...; Region: MLE; cd03318 762376005597 octamer interface [polypeptide binding]; other site 762376005598 active site 762376005599 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 762376005600 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 762376005601 Active site [active] 762376005602 benzoate transport; Region: 2A0115; TIGR00895 762376005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005605 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376005606 NAD(P) binding site [chemical binding]; other site 762376005607 active site 762376005608 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005611 dimerization interface [polypeptide binding]; other site 762376005612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005614 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 762376005615 amidohydrolase; Region: amidohydrolases; TIGR01891 762376005616 putative metal binding site [ion binding]; other site 762376005617 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 762376005618 DNA polymerase I; Provisional; Region: PRK05755 762376005619 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762376005620 active site 762376005621 metal binding site 1 [ion binding]; metal-binding site 762376005622 putative 5' ssDNA interaction site; other site 762376005623 metal binding site 3; metal-binding site 762376005624 metal binding site 2 [ion binding]; metal-binding site 762376005625 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762376005626 putative DNA binding site [nucleotide binding]; other site 762376005627 putative metal binding site [ion binding]; other site 762376005628 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 762376005629 active site 762376005630 catalytic site [active] 762376005631 substrate binding site [chemical binding]; other site 762376005632 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762376005633 active site 762376005634 DNA binding site [nucleotide binding] 762376005635 catalytic site [active] 762376005636 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 762376005637 Dienelactone hydrolase family; Region: DLH; pfam01738 762376005638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376005639 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 762376005640 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 762376005641 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 762376005642 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 762376005643 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 762376005644 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762376005645 Peptidase family M48; Region: Peptidase_M48; cl12018 762376005646 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762376005647 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 762376005648 active site residue [active] 762376005649 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 762376005650 active site residue [active] 762376005651 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376005652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005653 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 762376005654 putative dimerization interface [polypeptide binding]; other site 762376005655 putative effector binding pocket; other site 762376005656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005657 putative substrate translocation pore; other site 762376005658 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl14899 762376005659 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376005660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005661 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376005662 dimerization interface [polypeptide binding]; other site 762376005663 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 762376005664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376005665 Walker A/P-loop; other site 762376005666 ATP binding site [chemical binding]; other site 762376005667 Q-loop/lid; other site 762376005668 ABC transporter signature motif; other site 762376005669 Walker B; other site 762376005670 D-loop; other site 762376005671 H-loop/switch region; other site 762376005672 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 762376005673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376005675 dimer interface [polypeptide binding]; other site 762376005676 conserved gate region; other site 762376005677 putative PBP binding loops; other site 762376005678 ABC-ATPase subunit interface; other site 762376005679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376005680 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762376005681 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 762376005682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005683 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376005684 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 762376005685 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 762376005686 putative hydrophobic ligand binding site [chemical binding]; other site 762376005687 protein interface [polypeptide binding]; other site 762376005688 gate; other site 762376005689 Dienelactone hydrolase family; Region: DLH; pfam01738 762376005690 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376005691 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376005692 Zn binding site [ion binding]; other site 762376005693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376005694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005695 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376005696 putative dimerization interface [polypeptide binding]; other site 762376005697 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376005698 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 762376005699 [2Fe-2S] cluster binding site [ion binding]; other site 762376005700 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 762376005701 alpha subunit interface [polypeptide binding]; other site 762376005702 active site 762376005703 substrate binding site [chemical binding]; other site 762376005704 Fe binding site [ion binding]; other site 762376005705 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 762376005706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005708 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005710 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 762376005711 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762376005712 substrate binding pocket [chemical binding]; other site 762376005713 chain length determination region; other site 762376005714 substrate-Mg2+ binding site; other site 762376005715 catalytic residues [active] 762376005716 aspartate-rich region 1; other site 762376005717 active site lid residues [active] 762376005718 aspartate-rich region 2; other site 762376005719 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 762376005720 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 762376005721 TPP-binding site; other site 762376005722 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376005723 PYR/PP interface [polypeptide binding]; other site 762376005724 dimer interface [polypeptide binding]; other site 762376005725 TPP binding site [chemical binding]; other site 762376005726 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376005727 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 762376005728 Protein of unknown function (DUF817); Region: DUF817; cl01520 762376005729 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 762376005730 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 762376005731 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 762376005732 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762376005733 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762376005734 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762376005735 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376005736 replicative DNA helicase; Provisional; Region: PRK07004 762376005737 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762376005738 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762376005739 Walker A motif; other site 762376005740 ATP binding site [chemical binding]; other site 762376005741 Walker B motif; other site 762376005742 DNA binding loops [nucleotide binding] 762376005743 Membrane transport protein; Region: Mem_trans; cl09117 762376005744 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 762376005745 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376005746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376005747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005748 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376005749 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376005750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376005751 DNA-binding site [nucleotide binding]; DNA binding site 762376005752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005754 homodimer interface [polypeptide binding]; other site 762376005755 catalytic residue [active] 762376005756 Predicted flavoproteins [General function prediction only]; Region: COG2081 762376005757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376005758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376005759 Entericidin EcnA/B family; Region: Entericidin; cl02322 762376005760 aspartate carbamoyltransferase; Provisional; Region: PRK11891 762376005761 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762376005762 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376005763 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 762376005764 heme-binding site [chemical binding]; other site 762376005765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376005766 metal binding site [ion binding]; metal-binding site 762376005767 active site 762376005768 I-site; other site 762376005769 Putative exonuclease, RdgC; Region: RdgC; cl01122 762376005770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005771 putative substrate translocation pore; other site 762376005772 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376005773 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376005774 sensor protein BasS/PmrB; Provisional; Region: PRK10755 762376005775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376005776 dimer interface [polypeptide binding]; other site 762376005777 phosphorylation site [posttranslational modification] 762376005778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376005779 ATP binding site [chemical binding]; other site 762376005780 G-X-G motif; other site 762376005781 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376005782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376005783 active site 762376005784 phosphorylation site [posttranslational modification] 762376005785 intermolecular recognition site; other site 762376005786 dimerization interface [polypeptide binding]; other site 762376005787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376005788 DNA binding site [nucleotide binding] 762376005789 recombinase A; Provisional; Region: recA; PRK09354 762376005790 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762376005791 hexamer interface [polypeptide binding]; other site 762376005792 Walker A motif; other site 762376005793 ATP binding site [chemical binding]; other site 762376005794 Walker B motif; other site 762376005795 RecX family; Region: RecX; cl00936 762376005796 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 762376005797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005798 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 762376005799 putative dimerization interface [polypeptide binding]; other site 762376005800 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 762376005801 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 762376005802 THF binding site; other site 762376005803 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 762376005804 substrate binding site [chemical binding]; other site 762376005805 THF binding site; other site 762376005806 zinc-binding site [ion binding]; other site 762376005807 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 762376005808 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376005809 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 762376005810 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376005811 putative trimer interface [polypeptide binding]; other site 762376005812 putative CoA binding site [chemical binding]; other site 762376005813 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376005814 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376005815 putative trimer interface [polypeptide binding]; other site 762376005816 putative CoA binding site [chemical binding]; other site 762376005817 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762376005818 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 762376005819 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 762376005820 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376005821 CoA-ligase; Region: Ligase_CoA; pfam00549 762376005822 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 762376005823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005824 CoA-ligase; Region: Ligase_CoA; pfam00549 762376005825 Integral membrane protein TerC family; Region: TerC; cl10468 762376005826 Integral membrane protein TerC family; Region: TerC; cl10468 762376005827 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 762376005828 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 762376005829 domain interfaces; other site 762376005830 active site 762376005831 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 762376005832 active site 762376005833 HemX; Region: HemX; cl14667 762376005834 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 762376005835 HemY protein N-terminus; Region: HemY_N; pfam07219 762376005836 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 762376005837 dimer interface [polypeptide binding]; other site 762376005838 substrate binding site [chemical binding]; other site 762376005839 metal binding sites [ion binding]; metal-binding site 762376005840 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376005843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005844 NAD(P) binding site [chemical binding]; other site 762376005845 active site 762376005846 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376005847 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376005848 putative ligand binding site [chemical binding]; other site 762376005849 Cupin domain; Region: Cupin_2; cl09118 762376005850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376005852 NAD(P) binding site [chemical binding]; other site 762376005853 active site 762376005854 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376005855 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376005856 Walker A/P-loop; other site 762376005857 ATP binding site [chemical binding]; other site 762376005858 Q-loop/lid; other site 762376005859 ABC transporter signature motif; other site 762376005860 Walker B; other site 762376005861 D-loop; other site 762376005862 H-loop/switch region; other site 762376005863 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376005864 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376005865 Walker A/P-loop; other site 762376005866 ATP binding site [chemical binding]; other site 762376005867 Q-loop/lid; other site 762376005868 ABC transporter signature motif; other site 762376005869 Walker B; other site 762376005870 D-loop; other site 762376005871 H-loop/switch region; other site 762376005872 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376005873 TM-ABC transporter signature motif; other site 762376005874 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376005875 TM-ABC transporter signature motif; other site 762376005876 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 762376005877 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376005878 Entericidin EcnA/B family; Region: Entericidin; cl02322 762376005879 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 762376005880 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 762376005881 putative active site [active] 762376005882 PhoH-like protein; Region: PhoH; cl12134 762376005883 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 762376005884 catalytic triad [active] 762376005885 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560 762376005886 aspartate aminotransferase; Provisional; Region: PRK07681 762376005887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005889 homodimer interface [polypeptide binding]; other site 762376005890 catalytic residue [active] 762376005891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005892 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762376005893 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 762376005894 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762376005895 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 762376005896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005897 catalytic residue [active] 762376005898 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 762376005899 fructose-1,6-bisphosphatase family protein; Region: PLN02628 762376005900 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 762376005901 AMP binding site [chemical binding]; other site 762376005902 metal binding site [ion binding]; metal-binding site 762376005903 active site 762376005904 aminopeptidase N; Provisional; Region: pepN; PRK14015 762376005905 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 762376005906 active site 762376005907 Zn binding site [ion binding]; other site 762376005908 H-NS histone family; Region: Histone_HNS; pfam00816 762376005909 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 762376005910 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 762376005911 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 762376005912 NeuB family; Region: NeuB; cl00496 762376005913 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376005914 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 762376005915 FAD binding domain; Region: FAD_binding_4; pfam01565 762376005916 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 762376005917 FAD binding domain; Region: FAD_binding_4; pfam01565 762376005918 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 762376005919 FAD binding domain; Region: FAD_binding_4; pfam01565 762376005920 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 762376005921 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 762376005922 Cysteine-rich domain; Region: CCG; pfam02754 762376005923 Cysteine-rich domain; Region: CCG; pfam02754 762376005924 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 762376005925 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 762376005926 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 762376005927 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 762376005928 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376005929 N-formylglutamate amidohydrolase; Region: FGase; cl01522 762376005930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376005931 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005932 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376005933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376005934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005935 dimerization interface [polypeptide binding]; other site 762376005936 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 762376005937 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 762376005938 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 762376005939 putative glutathione S-transferase; Provisional; Region: PRK10357 762376005940 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376005941 putative C-terminal domain interface [polypeptide binding]; other site 762376005942 putative GSH binding site (G-site) [chemical binding]; other site 762376005943 putative dimer interface [polypeptide binding]; other site 762376005944 GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205 762376005945 putative N-terminal domain interface [polypeptide binding]; other site 762376005946 putative dimer interface [polypeptide binding]; other site 762376005947 putative substrate binding pocket (H-site) [chemical binding]; other site 762376005948 adenylosuccinate lyase; Provisional; Region: PRK09285 762376005949 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 762376005950 tetramer interface [polypeptide binding]; other site 762376005951 active site 762376005952 Cytochrome C'; Region: Cytochrom_C_2; cl01610 762376005953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376005954 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 762376005955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376005956 Coenzyme A binding pocket [chemical binding]; other site 762376005957 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 762376005958 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762376005959 Domain of unknown function DUF20; Region: UPF0118; cl00465 762376005960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376005961 metal binding site [ion binding]; metal-binding site 762376005962 active site 762376005963 I-site; other site 762376005964 aromatic amino acid exporter; Provisional; Region: PRK11689 762376005965 EamA-like transporter family; Region: EamA; cl01037 762376005966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376005967 TIGR03440 family protein; Region: unchr_TIGR03440 762376005968 DinB superfamily; Region: DinB_2; cl00986 762376005969 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 762376005970 probable methyltransferase; Region: TIGR03438 762376005971 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 762376005972 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 762376005973 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 762376005974 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376005975 putative active site [active] 762376005976 catalytic site [active] 762376005977 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 762376005978 putative active site [active] 762376005979 catalytic site [active] 762376005980 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 762376005981 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 762376005982 active site 762376005983 FMN binding site [chemical binding]; other site 762376005984 substrate binding site [chemical binding]; other site 762376005985 3Fe-4S cluster binding site [ion binding]; other site 762376005986 putative inner membrane protein; Provisional; Region: PRK11099 762376005987 YeeE/YedE family (DUF395); Region: DUF395; cl01018 762376005988 putative inner membrane protein; Provisional; Region: PRK11099 762376005989 arsenical pump membrane protein; Provisional; Region: PRK15445 762376005990 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 762376005991 transmembrane helices; other site 762376005992 Membrane transport protein; Region: Mem_trans; cl09117 762376005993 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376005994 EamA-like transporter family; Region: EamA; cl01037 762376005995 EamA-like transporter family; Region: EamA; cl01037 762376005996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376005997 Coenzyme A binding pocket [chemical binding]; other site 762376005998 DTW domain; Region: DTW; cl01221 762376005999 ribonuclease R; Region: RNase_R; TIGR02063 762376006000 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 762376006001 RNB domain; Region: RNB; pfam00773 762376006002 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 762376006003 RNA binding site [nucleotide binding]; other site 762376006004 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 762376006005 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762376006006 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762376006007 hypothetical protein; Provisional; Region: PRK05939 762376006008 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376006009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376006010 catalytic residue [active] 762376006011 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 762376006012 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 762376006013 IHF dimer interface [polypeptide binding]; other site 762376006014 IHF - DNA interface [nucleotide binding]; other site 762376006015 Gram-negative bacterial tonB protein; Region: TonB; cl10048 762376006016 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376006017 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762376006018 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 762376006019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376006020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376006021 active site 762376006022 phosphorylation site [posttranslational modification] 762376006023 intermolecular recognition site; other site 762376006024 dimerization interface [polypeptide binding]; other site 762376006025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376006026 DNA binding site [nucleotide binding] 762376006027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376006028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376006029 dimer interface [polypeptide binding]; other site 762376006030 phosphorylation site [posttranslational modification] 762376006031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006032 ATP binding site [chemical binding]; other site 762376006033 Mg2+ binding site [ion binding]; other site 762376006034 G-X-G motif; other site 762376006035 K+ potassium transporter; Region: K_trans; cl01227 762376006036 potassium uptake protein; Region: kup; TIGR00794 762376006037 argininosuccinate synthase; Region: argG; TIGR00032 762376006038 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 762376006039 Ligand Binding Site [chemical binding]; other site 762376006040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376006041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006042 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376006043 putative dimerization interface [polypeptide binding]; other site 762376006044 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 762376006045 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 762376006046 active site 762376006047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376006048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006049 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376006050 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376006051 ornithine carbamoyltransferase; Provisional; Region: PRK00779 762376006052 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762376006053 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376006054 acetylornithine aminotransferase; Provisional; Region: PRK02627 762376006055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376006056 inhibitor-cofactor binding pocket; inhibition site 762376006057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006058 catalytic residue [active] 762376006059 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 762376006060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376006061 DNA-binding site [nucleotide binding]; DNA binding site 762376006062 FCD domain; Region: FCD; cl11656 762376006063 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376006064 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376006065 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006067 dimer interface [polypeptide binding]; other site 762376006068 conserved gate region; other site 762376006069 putative PBP binding loops; other site 762376006070 ABC-ATPase subunit interface; other site 762376006071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376006072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006073 dimer interface [polypeptide binding]; other site 762376006074 conserved gate region; other site 762376006075 putative PBP binding loops; other site 762376006076 ABC-ATPase subunit interface; other site 762376006077 cytosine deaminase; Provisional; Region: PRK05985 762376006078 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 762376006079 active site 762376006080 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 762376006081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376006082 active site 762376006083 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376006084 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376006085 Walker A/P-loop; other site 762376006086 ATP binding site [chemical binding]; other site 762376006087 Q-loop/lid; other site 762376006088 ABC transporter signature motif; other site 762376006089 Walker B; other site 762376006090 D-loop; other site 762376006091 H-loop/switch region; other site 762376006092 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006093 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376006094 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376006095 Walker A/P-loop; other site 762376006096 ATP binding site [chemical binding]; other site 762376006097 Q-loop/lid; other site 762376006098 ABC transporter signature motif; other site 762376006099 Walker B; other site 762376006100 D-loop; other site 762376006101 H-loop/switch region; other site 762376006102 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006103 DctM-like transporters; Region: DctM; pfam06808 762376006104 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376006105 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376006106 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376006107 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 762376006108 FtsX-like permease family; Region: FtsX; pfam02687 762376006109 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 762376006110 apolar tunnel; other site 762376006111 heme binding site [chemical binding]; other site 762376006112 dimerization interface [polypeptide binding]; other site 762376006113 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376006114 ATP binding site [chemical binding]; other site 762376006115 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376006116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006117 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 762376006118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376006119 Walker A/P-loop; other site 762376006120 ATP binding site [chemical binding]; other site 762376006121 Q-loop/lid; other site 762376006122 ABC transporter signature motif; other site 762376006123 Walker B; other site 762376006124 D-loop; other site 762376006125 H-loop/switch region; other site 762376006126 TOBE domain; Region: TOBE_2; cl01440 762376006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006128 dimer interface [polypeptide binding]; other site 762376006129 conserved gate region; other site 762376006130 putative PBP binding loops; other site 762376006131 ABC-ATPase subunit interface; other site 762376006132 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006134 dimer interface [polypeptide binding]; other site 762376006135 conserved gate region; other site 762376006136 putative PBP binding loops; other site 762376006137 ABC-ATPase subunit interface; other site 762376006138 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 762376006139 putative catalytic residues [active] 762376006140 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 762376006141 active site 762376006142 DNA binding site [nucleotide binding] 762376006143 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376006144 RmuC family; Region: RmuC; pfam02646 762376006145 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376006146 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376006147 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 762376006148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376006149 active site 762376006150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376006151 active site 762376006152 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762376006153 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376006154 active site 762376006155 dimer interface [polypeptide binding]; other site 762376006156 transcriptional regulator PhoU; Provisional; Region: PRK11115 762376006157 PhoU domain; Region: PhoU; pfam01895 762376006158 PhoU domain; Region: PhoU; pfam01895 762376006159 Pseudomonas-type; Region: PC_PLC; TIGR03396 762376006160 Phosphoesterase family; Region: Phosphoesterase; cl10627 762376006161 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376006162 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 762376006163 N-acetylglutamate synthase; Validated; Region: PRK05279 762376006164 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 762376006165 putative feedback inhibition sensing region; other site 762376006166 putative nucleotide binding site [chemical binding]; other site 762376006167 putative substrate binding site [chemical binding]; other site 762376006168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006169 Coenzyme A binding pocket [chemical binding]; other site 762376006170 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 762376006171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376006172 ATP binding site [chemical binding]; other site 762376006173 putative Mg++ binding site [ion binding]; other site 762376006174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376006175 nucleotide binding region [chemical binding]; other site 762376006176 ATP-binding site [chemical binding]; other site 762376006177 Helicase associated domain (HA2); Region: HA2; cl04503 762376006178 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 762376006179 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 762376006180 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 762376006181 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 762376006182 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 762376006183 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 762376006184 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 762376006185 generic binding surface I; other site 762376006186 generic binding surface II; other site 762376006187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006188 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006189 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762376006190 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376006191 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 762376006192 putative metal binding site [ion binding]; other site 762376006193 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006194 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006195 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376006196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006197 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006198 Flagellin N-methylase; Region: FliB; cl00497 762376006199 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762376006200 putative active site [active] 762376006201 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 762376006202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376006203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376006204 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 762376006205 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376006206 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 762376006207 Walker A/P-loop; other site 762376006208 ATP binding site [chemical binding]; other site 762376006209 Q-loop/lid; other site 762376006210 ABC transporter signature motif; other site 762376006211 Walker B; other site 762376006212 D-loop; other site 762376006213 H-loop/switch region; other site 762376006214 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762376006215 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762376006216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006218 metal binding site [ion binding]; metal-binding site 762376006219 active site 762376006220 I-site; other site 762376006221 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 762376006222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006223 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376006224 putative dimerization interface [polypeptide binding]; other site 762376006225 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376006226 DctM-like transporters; Region: DctM; pfam06808 762376006227 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376006228 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376006229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006230 NAD(P) binding site [chemical binding]; other site 762376006231 active site 762376006232 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376006233 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 762376006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376006235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376006236 Walker A/P-loop; other site 762376006237 ATP binding site [chemical binding]; other site 762376006238 Putative exonuclease, RdgC; Region: RdgC; cl01122 762376006239 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 762376006240 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762376006241 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 762376006242 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 762376006243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376006244 non-specific DNA binding site [nucleotide binding]; other site 762376006245 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 762376006246 salt bridge; other site 762376006247 sequence-specific DNA binding site [nucleotide binding]; other site 762376006248 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 762376006249 Catalytic site [active] 762376006250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376006251 non-specific DNA binding site [nucleotide binding]; other site 762376006252 salt bridge; other site 762376006253 sequence-specific DNA binding site [nucleotide binding]; other site 762376006254 Endodeoxyribonuclease RusA; Region: RusA; cl01885 762376006255 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 762376006256 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 762376006257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 762376006258 Terminase-like family; Region: Terminase_6; pfam03237 762376006259 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 762376006260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 762376006261 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 762376006262 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 762376006263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 762376006264 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 762376006265 Calicivirus minor structural protein; Region: Calici_MSP; pfam05752 762376006266 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 762376006267 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 762376006268 HeH/LEM domain; Region: HeH; pfam12949 762376006269 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 762376006270 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 762376006271 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 762376006272 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 762376006273 Baseplate J-like protein; Region: Baseplate_J; cl01294 762376006274 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 762376006275 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376006276 DNA binding site [nucleotide binding] 762376006277 Int/Topo IB signature motif; other site 762376006278 active site 762376006279 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376006280 catalytic residue [active] 762376006281 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 762376006282 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 762376006283 Phage integrase family; Region: Phage_integrase; pfam00589 762376006284 active site 762376006285 Int/Topo IB signature motif; other site 762376006286 ribonuclease G; Provisional; Region: PRK11712 762376006287 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762376006288 homodimer interface [polypeptide binding]; other site 762376006289 oligonucleotide binding site [chemical binding]; other site 762376006290 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376006291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376006292 active site 762376006293 phosphorylation site [posttranslational modification] 762376006294 intermolecular recognition site; other site 762376006295 dimerization interface [polypeptide binding]; other site 762376006296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376006297 Walker A motif; other site 762376006298 ATP binding site [chemical binding]; other site 762376006299 Walker B motif; other site 762376006300 arginine finger; other site 762376006301 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376006302 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 762376006303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376006304 phosphorylation site [posttranslational modification] 762376006305 dimer interface [polypeptide binding]; other site 762376006306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006307 ATP binding site [chemical binding]; other site 762376006308 Mg2+ binding site [ion binding]; other site 762376006309 G-X-G motif; other site 762376006310 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 762376006311 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762376006312 active site 762376006313 dimer interface [polypeptide binding]; other site 762376006314 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 762376006315 Domain of unknown function DUF143; Region: DUF143; cl00519 762376006316 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 762376006317 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762376006318 active site 762376006319 (T/H)XGH motif; other site 762376006320 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 762376006321 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762376006322 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762376006323 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376006324 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762376006325 Domain of unknown function DUF28; Region: DUF28; cl00361 762376006326 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 762376006327 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762376006328 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 762376006329 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376006330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006331 putative substrate translocation pore; other site 762376006332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006333 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 762376006334 NodT family; Region: outer_NodT; TIGR01845 762376006335 Outer membrane efflux protein; Region: OEP; pfam02321 762376006336 Outer membrane efflux protein; Region: OEP; pfam02321 762376006337 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376006338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006339 Predicted permeases [General function prediction only]; Region: RarD; COG2962 762376006340 EamA-like transporter family; Region: EamA; cl01037 762376006341 EamA-like transporter family; Region: EamA; cl01037 762376006342 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 762376006343 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 762376006344 NADP binding site [chemical binding]; other site 762376006345 dimer interface [polypeptide binding]; other site 762376006346 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376006347 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376006348 NAD(P) binding site [chemical binding]; other site 762376006349 catalytic residues [active] 762376006350 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 762376006351 methylamine dehydrogenase heavy chain; Region: TTQ_MADH_Hv; TIGR02658 762376006352 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376006353 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 762376006354 Cytochrome c; Region: Cytochrom_C; cl11414 762376006355 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376006356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376006357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 762376006358 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 762376006359 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 762376006360 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376006361 metal binding triad; other site 762376006362 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376006363 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376006364 metal binding triad; other site 762376006365 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376006366 TIGR02099 family protein; Region: TIGR02099 762376006367 transcription termination factor Rho; Provisional; Region: rho; PRK09376 762376006368 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 762376006369 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 762376006370 RNA binding site [nucleotide binding]; other site 762376006371 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 762376006372 multimer interface [polypeptide binding]; other site 762376006373 Walker A motif; other site 762376006374 ATP binding site [chemical binding]; other site 762376006375 Walker B motif; other site 762376006376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376006377 catalytic residues [active] 762376006378 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 762376006379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006380 ATP binding site [chemical binding]; other site 762376006381 Mg2+ binding site [ion binding]; other site 762376006382 G-X-G motif; other site 762376006383 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 762376006384 anchoring element; other site 762376006385 dimer interface [polypeptide binding]; other site 762376006386 ATP binding site [chemical binding]; other site 762376006387 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 762376006388 active site 762376006389 metal binding site [ion binding]; metal-binding site 762376006390 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762376006391 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762376006392 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 762376006393 CAP-like domain; other site 762376006394 Active site [active] 762376006395 primary dimer interface [polypeptide binding]; other site 762376006396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376006397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376006398 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376006399 Predicted membrane protein [Function unknown]; Region: COG2311 762376006400 Protein of unknown function (DUF418); Region: DUF418; cl12135 762376006401 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376006402 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376006403 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 762376006404 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 762376006405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006406 hypothetical protein; Provisional; Region: PRK07483 762376006407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376006408 inhibitor-cofactor binding pocket; inhibition site 762376006409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006410 catalytic residue [active] 762376006411 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376006412 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376006413 putative active site [active] 762376006414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006416 Coenzyme A binding pocket [chemical binding]; other site 762376006417 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 762376006418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376006419 inhibitor-cofactor binding pocket; inhibition site 762376006420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006421 catalytic residue [active] 762376006422 Cupin domain; Region: Cupin_2; cl09118 762376006423 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376006424 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 762376006425 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 762376006426 MOSC domain; Region: MOSC; pfam03473 762376006427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376006428 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376006429 active site 762376006430 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376006431 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 762376006432 tetramerization interface [polypeptide binding]; other site 762376006433 active site 762376006434 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376006435 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376006436 catalytic loop [active] 762376006437 iron binding site [ion binding]; other site 762376006438 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 762376006439 FAD binding pocket [chemical binding]; other site 762376006440 FAD binding motif [chemical binding]; other site 762376006441 phosphate binding motif [ion binding]; other site 762376006442 beta-alpha-beta structure motif; other site 762376006443 NAD binding pocket [chemical binding]; other site 762376006444 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376006445 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 762376006446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376006447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006448 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 762376006449 VirB7 interaction site; other site 762376006450 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 762376006451 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376006452 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376006453 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 762376006454 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376006455 Walker A motif; other site 762376006456 ATP binding site [chemical binding]; other site 762376006457 Walker B motif; other site 762376006458 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762376006459 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 762376006460 motif 1; other site 762376006461 active site 762376006462 motif 2; other site 762376006463 motif 3; other site 762376006464 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 762376006465 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 762376006466 CPxP motif; other site 762376006467 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 762376006468 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762376006469 RimM N-terminal domain; Region: RimM; pfam01782 762376006470 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 762376006471 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 762376006472 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762376006473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376006474 active site 762376006475 HIGH motif; other site 762376006476 nucleotide binding site [chemical binding]; other site 762376006477 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762376006478 active site 762376006479 KMSKS motif; other site 762376006480 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762376006481 tRNA binding surface [nucleotide binding]; other site 762376006482 anticodon binding site; other site 762376006483 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762376006484 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762376006485 active site 762376006486 multimer interface [polypeptide binding]; other site 762376006487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376006488 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 762376006489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376006490 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 762376006491 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 762376006492 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762376006493 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 762376006494 dimer interface [polypeptide binding]; other site 762376006495 motif 1; other site 762376006496 active site 762376006497 motif 2; other site 762376006498 motif 3; other site 762376006499 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762376006500 anticodon binding site; other site 762376006501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 762376006502 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 762376006503 GTP-binding protein Der; Reviewed; Region: PRK00093 762376006504 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 762376006505 G1 box; other site 762376006506 GTP/Mg2+ binding site [chemical binding]; other site 762376006507 Switch I region; other site 762376006508 G2 box; other site 762376006509 Switch II region; other site 762376006510 G3 box; other site 762376006511 G4 box; other site 762376006512 G5 box; other site 762376006513 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 762376006514 G1 box; other site 762376006515 GTP/Mg2+ binding site [chemical binding]; other site 762376006516 Switch I region; other site 762376006517 G2 box; other site 762376006518 G3 box; other site 762376006519 Switch II region; other site 762376006520 G4 box; other site 762376006521 G5 box; other site 762376006522 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 762376006523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376006524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006525 homodimer interface [polypeptide binding]; other site 762376006526 catalytic residue [active] 762376006527 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 762376006528 Sm1 motif; other site 762376006529 intra - hexamer interaction site; other site 762376006530 inter - hexamer interaction site [polypeptide binding]; other site 762376006531 nucleotide binding pocket [chemical binding]; other site 762376006532 Sm2 motif; other site 762376006533 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762376006534 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 762376006535 G1 box; other site 762376006536 GTP/Mg2+ binding site [chemical binding]; other site 762376006537 Switch I region; other site 762376006538 G2 box; other site 762376006539 G3 box; other site 762376006540 Switch II region; other site 762376006541 G4 box; other site 762376006542 G5 box; other site 762376006543 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 762376006544 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 762376006545 HflK protein; Region: hflK; TIGR01933 762376006546 FtsH protease regulator HflC; Provisional; Region: PRK11029 762376006547 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 762376006548 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 762376006549 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 762376006550 dimer interface [polypeptide binding]; other site 762376006551 motif 1; other site 762376006552 active site 762376006553 motif 2; other site 762376006554 motif 3; other site 762376006555 adenylosuccinate synthetase; Provisional; Region: PRK01117 762376006556 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 762376006557 GDP-binding site [chemical binding]; other site 762376006558 ACT binding site; other site 762376006559 IMP binding site; other site 762376006560 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376006561 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 762376006562 DNA primase, catalytic core; Region: dnaG; TIGR01391 762376006563 CHC2 zinc finger; Region: zf-CHC2; cl02597 762376006564 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762376006565 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762376006566 active site 762376006567 metal binding site [ion binding]; metal-binding site 762376006568 interdomain interaction site; other site 762376006569 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 762376006570 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 762376006571 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 762376006572 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 762376006573 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762376006574 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 762376006575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376006576 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762376006577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376006578 DNA binding residues [nucleotide binding] 762376006579 Family of unknown function (DUF500); Region: DUF500; cl01109 762376006580 transcriptional regulator; Provisional; Region: PRK10632 762376006581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006582 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376006583 putative effector binding pocket; other site 762376006584 dimerization interface [polypeptide binding]; other site 762376006585 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376006586 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376006587 thiolase; Provisional; Region: PRK06158 762376006588 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376006589 active site 762376006590 Coenzyme A transferase; Region: CoA_trans; cl00773 762376006591 Coenzyme A transferase; Region: CoA_trans; cl00773 762376006592 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376006593 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376006594 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376006595 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 762376006596 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376006597 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376006598 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376006599 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376006600 carboxyltransferase (CT) interaction site; other site 762376006601 biotinylation site [posttranslational modification]; other site 762376006602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376006603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376006605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006606 NAD(P) binding site [chemical binding]; other site 762376006607 active site 762376006608 enoyl-CoA hydratase; Region: PLN02864 762376006609 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376006610 dimer interaction site [polypeptide binding]; other site 762376006611 substrate-binding tunnel; other site 762376006612 active site 762376006613 catalytic site [active] 762376006614 substrate binding site [chemical binding]; other site 762376006615 SAF domain; Region: SAF; cl00555 762376006616 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 762376006617 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376006618 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762376006619 phosphopeptide binding site; other site 762376006620 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 762376006621 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 762376006622 ATP binding site [chemical binding]; other site 762376006623 Walker A motif; other site 762376006624 hexamer interface [polypeptide binding]; other site 762376006625 Walker B motif; other site 762376006626 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762376006627 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762376006628 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 762376006629 Phosphotransferase enzyme family; Region: APH; pfam01636 762376006630 putative active site [active] 762376006631 putative substrate binding site [chemical binding]; other site 762376006632 ATP binding site [chemical binding]; other site 762376006633 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 762376006634 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 762376006635 FMN binding site [chemical binding]; other site 762376006636 active site 762376006637 catalytic residues [active] 762376006638 substrate binding site [chemical binding]; other site 762376006639 FOG: CBS domain [General function prediction only]; Region: COG0517 762376006640 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_12; cd04625 762376006641 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 762376006642 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 762376006643 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 762376006644 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 762376006645 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 762376006646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376006647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376006648 active site 762376006649 phosphorylation site [posttranslational modification] 762376006650 intermolecular recognition site; other site 762376006651 dimerization interface [polypeptide binding]; other site 762376006652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376006653 DNA binding site [nucleotide binding] 762376006654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376006655 dimer interface [polypeptide binding]; other site 762376006656 phosphorylation site [posttranslational modification] 762376006657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006658 ATP binding site [chemical binding]; other site 762376006659 Mg2+ binding site [ion binding]; other site 762376006660 G-X-G motif; other site 762376006661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006662 metal binding site [ion binding]; metal-binding site 762376006663 active site 762376006664 I-site; other site 762376006665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376006666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006667 metal binding site [ion binding]; metal-binding site 762376006668 active site 762376006669 I-site; other site 762376006670 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376006671 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762376006672 Tetramer interface [polypeptide binding]; other site 762376006673 Active site [active] 762376006674 FMN-binding site [chemical binding]; other site 762376006675 Peptidase family M48; Region: Peptidase_M48; cl12018 762376006676 regulatory protein CsrD; Provisional; Region: PRK11059 762376006677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006678 metal binding site [ion binding]; metal-binding site 762376006679 active site 762376006680 I-site; other site 762376006681 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376006682 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479 762376006683 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006684 Putative Ig domain; Region: He_PIG; cl09256 762376006685 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006686 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006687 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006688 Putative Ig domain; Region: He_PIG; cl09256 762376006689 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006690 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762376006691 metal ion-dependent adhesion site (MIDAS); other site 762376006692 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006693 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006694 DinB superfamily; Region: DinB_2; cl00986 762376006695 Putative Ig domain; Region: He_PIG; cl09256 762376006696 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006697 Putative Ig domain; Region: He_PIG; cl09256 762376006698 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006699 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376006700 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762376006701 metal ion-dependent adhesion site (MIDAS); other site 762376006702 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 762376006703 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006704 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 762376006705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376006706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376006707 DNA binding residues [nucleotide binding] 762376006708 dimerization interface [polypeptide binding]; other site 762376006709 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 762376006710 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 762376006711 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 762376006712 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376006713 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 762376006714 Walker A/P-loop; other site 762376006715 ATP binding site [chemical binding]; other site 762376006716 Q-loop/lid; other site 762376006717 ABC transporter signature motif; other site 762376006718 Walker B; other site 762376006719 D-loop; other site 762376006720 H-loop/switch region; other site 762376006721 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 762376006722 Outer membrane efflux protein; Region: OEP; pfam02321 762376006723 Outer membrane efflux protein; Region: OEP; pfam02321 762376006724 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376006725 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762376006726 substrate binding site [chemical binding]; other site 762376006727 ligand binding site [chemical binding]; other site 762376006728 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 762376006729 substrate binding site [chemical binding]; other site 762376006730 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762376006731 isocitrate dehydrogenase; Validated; Region: PRK06451 762376006732 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 762376006733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006734 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 762376006735 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 762376006736 FimV N-terminal domain; Region: FimV_core; TIGR03505 762376006737 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762376006738 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 762376006739 dimerization interface 3.5A [polypeptide binding]; other site 762376006740 active site 762376006741 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376006742 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 762376006743 active site 762376006744 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 762376006745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006746 metal binding site [ion binding]; metal-binding site 762376006747 active site 762376006748 I-site; other site 762376006749 LysE type translocator; Region: LysE; cl00565 762376006750 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 762376006751 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376006752 Protein of unknown function (DUF454); Region: DUF454; cl01063 762376006753 Dehydratase family; Region: ILVD_EDD; cl00340 762376006754 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376006755 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376006756 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376006757 DctM-like transporters; Region: DctM; pfam06808 762376006758 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376006759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376006760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376006761 DNA binding site [nucleotide binding] 762376006762 domain linker motif; other site 762376006763 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 762376006764 putative dimerization interface [polypeptide binding]; other site 762376006765 putative ligand binding site [chemical binding]; other site 762376006766 Cupin domain; Region: Cupin_2; cl09118 762376006767 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376006768 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376006769 Walker A/P-loop; other site 762376006770 ATP binding site [chemical binding]; other site 762376006771 Q-loop/lid; other site 762376006772 ABC transporter signature motif; other site 762376006773 Walker B; other site 762376006774 D-loop; other site 762376006775 H-loop/switch region; other site 762376006776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006777 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376006778 Walker A/P-loop; other site 762376006779 ATP binding site [chemical binding]; other site 762376006780 Q-loop/lid; other site 762376006781 ABC transporter signature motif; other site 762376006782 Walker B; other site 762376006783 D-loop; other site 762376006784 H-loop/switch region; other site 762376006785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006786 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376006787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006788 dimer interface [polypeptide binding]; other site 762376006789 conserved gate region; other site 762376006790 putative PBP binding loops; other site 762376006791 ABC-ATPase subunit interface; other site 762376006792 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006794 dimer interface [polypeptide binding]; other site 762376006795 conserved gate region; other site 762376006796 putative PBP binding loops; other site 762376006797 ABC-ATPase subunit interface; other site 762376006798 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376006799 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376006800 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376006801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376006802 DNA-binding site [nucleotide binding]; DNA binding site 762376006803 FCD domain; Region: FCD; cl11656 762376006804 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376006805 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 762376006806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376006807 FeS/SAM binding site; other site 762376006808 HemN C-terminal region; Region: HemN_C; pfam06969 762376006809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376006810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376006811 active site 762376006812 phosphorylation site [posttranslational modification] 762376006813 intermolecular recognition site; other site 762376006814 dimerization interface [polypeptide binding]; other site 762376006815 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376006816 DNA binding residues [nucleotide binding] 762376006817 dimerization interface [polypeptide binding]; other site 762376006818 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762376006819 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 762376006820 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 762376006821 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762376006822 active site 762376006823 dimer interface [polypeptide binding]; other site 762376006824 motif 1; other site 762376006825 motif 2; other site 762376006826 motif 3; other site 762376006827 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762376006828 anticodon binding site; other site 762376006829 translation initiation factor IF-3; Region: infC; TIGR00168 762376006830 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762376006831 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762376006832 glutathione synthetase; Provisional; Region: PRK05246 762376006833 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 762376006834 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376006835 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 762376006836 active pocket/dimerization site; other site 762376006837 active site 762376006838 phosphorylation site [posttranslational modification] 762376006839 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762376006840 dimerization domain swap beta strand [polypeptide binding]; other site 762376006841 regulatory protein interface [polypeptide binding]; other site 762376006842 active site 762376006843 regulatory phosphorylation site [posttranslational modification]; other site 762376006844 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762376006845 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762376006846 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 762376006847 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376006848 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 762376006849 Nitrogen regulatory protein P-II; Region: P-II; cl00412 762376006850 Membrane fusogenic activity; Region: BMFP; cl01115 762376006851 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 762376006852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376006853 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 762376006854 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762376006855 23S rRNA binding site [nucleotide binding]; other site 762376006856 L21 binding site [polypeptide binding]; other site 762376006857 L13 binding site [polypeptide binding]; other site 762376006858 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762376006859 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762376006860 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762376006861 dimer interface [polypeptide binding]; other site 762376006862 motif 1; other site 762376006863 active site 762376006864 motif 2; other site 762376006865 motif 3; other site 762376006866 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762376006867 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762376006868 putative tRNA-binding site [nucleotide binding]; other site 762376006869 B3/4 domain; Region: B3_4; cl11458 762376006870 tRNA synthetase B5 domain; Region: B5; cl08394 762376006871 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762376006872 dimer interface [polypeptide binding]; other site 762376006873 motif 1; other site 762376006874 motif 3; other site 762376006875 motif 2; other site 762376006876 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762376006877 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 762376006878 IHF - DNA interface [nucleotide binding]; other site 762376006879 IHF dimer interface [polypeptide binding]; other site 762376006880 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 762376006881 DNA binding residues [nucleotide binding] 762376006882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376006883 Rhomboid family; Region: Rhomboid; cl11446 762376006884 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376006885 classical (c) SDRs; Region: SDR_c; cd05233 762376006886 NAD(P) binding site [chemical binding]; other site 762376006887 active site 762376006888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376006889 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 762376006890 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 762376006891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006892 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376006893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376006894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006895 Dehydratase family; Region: ILVD_EDD; cl00340 762376006896 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376006897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376006898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006899 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376006900 putative dimerization interface [polypeptide binding]; other site 762376006901 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376006902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006904 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376006905 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762376006906 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376006907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006908 Coenzyme A binding pocket [chemical binding]; other site 762376006909 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 762376006910 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 762376006911 active site 762376006912 Zn-binding site [ion binding]; other site 762376006913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376006914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006915 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376006916 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376006917 putative active site [active] 762376006918 Family of unknown function (DUF500); Region: DUF500; cl01109 762376006919 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 762376006920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006921 EamA-like transporter family; Region: EamA; cl01037 762376006922 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376006923 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376006924 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 762376006925 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 762376006926 dimerization interface [polypeptide binding]; other site 762376006927 putative active cleft [active] 762376006928 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376006929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006930 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376006931 dimerization interface [polypeptide binding]; other site 762376006932 substrate binding pocket [chemical binding]; other site 762376006933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376006934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006935 N-formylglutamate amidohydrolase; Region: FGase; cl01522 762376006936 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376006937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376006938 substrate binding pocket [chemical binding]; other site 762376006939 membrane-bound complex binding site; other site 762376006940 hinge residues; other site 762376006941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376006942 dimer interface [polypeptide binding]; other site 762376006943 ABC-ATPase subunit interface; other site 762376006944 putative PBP binding loops; other site 762376006945 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376006946 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376006947 Walker A/P-loop; other site 762376006948 ATP binding site [chemical binding]; other site 762376006949 Q-loop/lid; other site 762376006950 ABC transporter signature motif; other site 762376006951 Walker B; other site 762376006952 D-loop; other site 762376006953 H-loop/switch region; other site 762376006954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376006955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006956 dimerization interface [polypeptide binding]; other site 762376006957 Membrane transport protein; Region: Mem_trans; cl09117 762376006958 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 762376006959 iron-sulfur cluster [ion binding]; other site 762376006960 [2Fe-2S] cluster binding site [ion binding]; other site 762376006961 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376006962 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 762376006963 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 762376006964 Walker A/P-loop; other site 762376006965 ATP binding site [chemical binding]; other site 762376006966 Q-loop/lid; other site 762376006967 ABC transporter signature motif; other site 762376006968 Walker B; other site 762376006969 D-loop; other site 762376006970 H-loop/switch region; other site 762376006971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376006972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376006973 active site 762376006974 catalytic tetrad [active] 762376006975 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376006976 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 762376006977 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376006978 active site 762376006979 metal binding site [ion binding]; metal-binding site 762376006980 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 762376006981 Transglycosylase; Region: Transgly; cl07896 762376006982 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762376006983 Cupin domain; Region: Cupin_2; cl09118 762376006984 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376006985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376006987 putative substrate translocation pore; other site 762376006988 hemin storage system protein; Provisional; Region: hmsS; cl14676 762376006989 N-glycosyltransferase; Provisional; Region: PRK11204 762376006990 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 762376006991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762376006992 DXD motif; other site 762376006993 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 762376006994 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376006995 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 762376006996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006997 metal binding site [ion binding]; metal-binding site 762376006998 active site 762376006999 I-site; other site 762376007000 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762376007001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376007002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007004 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376007005 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376007006 active site 762376007007 metal binding site [ion binding]; metal-binding site 762376007008 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376007009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007010 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376007011 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376007012 CoenzymeA binding site [chemical binding]; other site 762376007013 subunit interaction site [polypeptide binding]; other site 762376007014 PHB binding site; other site 762376007015 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762376007016 active site 762376007017 DNA polymerase IV; Validated; Region: PRK02406 762376007018 DNA binding site [nucleotide binding] 762376007019 GatB domain; Region: GatB_Yqey; cl11497 762376007020 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 762376007021 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762376007022 dimer interface [polypeptide binding]; other site 762376007023 active site 762376007024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007025 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 762376007026 NAD(P) binding site [chemical binding]; other site 762376007027 active site 762376007028 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 762376007029 putative active site 1 [active] 762376007030 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 762376007031 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 762376007032 active site 762376007033 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 762376007034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007035 Predicted exporter [General function prediction only]; Region: COG4258 762376007036 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 762376007037 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 762376007038 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376007039 active site 762376007040 Predicted acyltransferase [General function prediction only]; Region: COG4261 762376007041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376007042 putative acyl-acceptor binding pocket; other site 762376007043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762376007044 active site 762376007045 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376007046 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007047 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376007048 active site 2 [active] 762376007049 Predicted membrane protein [Function unknown]; Region: COG4648 762376007050 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007051 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376007053 putative acyl-acceptor binding pocket; other site 762376007054 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762376007055 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 762376007056 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 762376007057 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 762376007058 heme-binding site [chemical binding]; other site 762376007059 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 762376007060 FAD binding pocket [chemical binding]; other site 762376007061 FAD binding motif [chemical binding]; other site 762376007062 phosphate binding motif [ion binding]; other site 762376007063 beta-alpha-beta structure motif; other site 762376007064 NAD binding pocket [chemical binding]; other site 762376007065 Heme binding pocket [chemical binding]; other site 762376007066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007067 Rrf2 family protein; Region: rrf2_super; TIGR00738 762376007068 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376007069 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 762376007070 EamA-like transporter family; Region: EamA; cl01037 762376007071 EamA-like transporter family; Region: EamA; cl01037 762376007072 Proline dehydrogenase; Region: Pro_dh; cl03282 762376007073 Cupin domain; Region: Cupin_2; cl09118 762376007074 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376007075 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007078 dimerization interface [polypeptide binding]; other site 762376007079 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376007080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376007081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376007082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007084 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 762376007085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007087 transcriptional regulator; Provisional; Region: PRK10632 762376007088 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 762376007089 putative effector binding pocket; other site 762376007090 putative dimerization interface [polypeptide binding]; other site 762376007091 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376007092 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 762376007093 putative C-terminal domain interface [polypeptide binding]; other site 762376007094 putative GSH binding site (G-site) [chemical binding]; other site 762376007095 putative dimer interface [polypeptide binding]; other site 762376007096 GST_C family, unknown subfamily 7; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_7; cd03206 762376007097 putative N-terminal domain interface [polypeptide binding]; other site 762376007098 putative dimer interface [polypeptide binding]; other site 762376007099 putative substrate binding pocket (H-site) [chemical binding]; other site 762376007100 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376007101 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376007102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007103 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 762376007104 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 762376007105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376007106 active site 762376007107 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376007108 acyl-CoA synthetase; Validated; Region: PRK08162 762376007109 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007110 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376007111 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376007112 ligand binding site [chemical binding]; other site 762376007113 flexible hinge region; other site 762376007114 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376007115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007116 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 762376007117 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 762376007118 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376007119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376007120 ligand binding site [chemical binding]; other site 762376007121 flexible hinge region; other site 762376007122 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376007123 putative switch regulator; other site 762376007124 non-specific DNA interactions [nucleotide binding]; other site 762376007125 DNA binding site [nucleotide binding] 762376007126 sequence specific DNA binding site [nucleotide binding]; other site 762376007127 putative cAMP binding site [chemical binding]; other site 762376007128 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 762376007129 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376007130 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376007131 Cytochrome c; Region: Cytochrom_C; cl11414 762376007132 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 762376007133 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376007134 dimer interface [polypeptide binding]; other site 762376007135 TPP-binding site [chemical binding]; other site 762376007136 LysE type translocator; Region: LysE; cl00565 762376007137 glutathione reductase; Validated; Region: PRK06116 762376007138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007139 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376007140 Protein of unknown function DUF72; Region: DUF72; cl00777 762376007141 LysE type translocator; Region: LysE; cl00565 762376007142 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376007143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007144 DNA-binding site [nucleotide binding]; DNA binding site 762376007145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376007146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376007147 homodimer interface [polypeptide binding]; other site 762376007148 catalytic residue [active] 762376007149 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376007150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376007151 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376007152 EamA-like transporter family; Region: EamA; cl01037 762376007153 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376007154 catalytic residues [active] 762376007155 allantoate amidohydrolase; Reviewed; Region: PRK12890 762376007156 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376007157 active site 762376007158 metal binding site [ion binding]; metal-binding site 762376007159 dimer interface [polypeptide binding]; other site 762376007160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007163 dimerization interface [polypeptide binding]; other site 762376007164 enoyl-CoA hydratase; Provisional; Region: PRK05995 762376007165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376007166 substrate binding site [chemical binding]; other site 762376007167 oxyanion hole (OAH) forming residues; other site 762376007168 trimer interface [polypeptide binding]; other site 762376007169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376007171 NAD(P) binding site [chemical binding]; other site 762376007172 active site 762376007173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376007174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376007175 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 762376007176 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376007177 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007178 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 762376007179 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 762376007180 active site 762376007181 substrate-binding site [chemical binding]; other site 762376007182 metal-binding site [ion binding] 762376007183 GTP binding site [chemical binding]; other site 762376007184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376007185 S-adenosylmethionine binding site [chemical binding]; other site 762376007186 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 762376007187 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376007188 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376007189 Walker A/P-loop; other site 762376007190 ATP binding site [chemical binding]; other site 762376007191 Q-loop/lid; other site 762376007192 ABC transporter signature motif; other site 762376007193 Walker B; other site 762376007194 D-loop; other site 762376007195 H-loop/switch region; other site 762376007196 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376007197 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376007198 Walker A/P-loop; other site 762376007199 ATP binding site [chemical binding]; other site 762376007200 Q-loop/lid; other site 762376007201 ABC transporter signature motif; other site 762376007202 Walker B; other site 762376007203 D-loop; other site 762376007204 H-loop/switch region; other site 762376007205 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376007206 TM-ABC transporter signature motif; other site 762376007207 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376007208 TM-ABC transporter signature motif; other site 762376007209 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376007210 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 762376007211 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376007212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007213 DNA-binding site [nucleotide binding]; DNA binding site 762376007214 FCD domain; Region: FCD; cl11656 762376007215 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 762376007216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007218 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376007219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007220 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376007221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007222 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376007223 putative dimerization interface [polypeptide binding]; other site 762376007224 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 762376007225 short chain dehydrogenase; Provisional; Region: PRK06841 762376007226 classical (c) SDRs; Region: SDR_c; cd05233 762376007227 NAD(P) binding site [chemical binding]; other site 762376007228 active site 762376007229 Flavin Reductases; Region: FlaRed; cl00801 762376007230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007231 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 762376007232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007233 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 762376007234 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376007235 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007237 Pirin-related protein [General function prediction only]; Region: COG1741 762376007238 Cupin domain; Region: Cupin_2; cl09118 762376007239 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 762376007240 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 762376007241 tetrathionate reductase subunit B; Provisional; Region: PRK14993 762376007242 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 762376007243 tetrathionate reductase subunit A; Provisional; Region: PRK14991 762376007244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376007245 molybdopterin cofactor binding site; other site 762376007246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376007247 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 762376007248 putative molybdopterin cofactor binding site; other site 762376007249 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 762376007250 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 762376007251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 762376007252 Cytochrome C biogenesis protein; Region: CcmH; cl01179 762376007253 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 762376007254 catalytic residues [active] 762376007255 central insert; other site 762376007256 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376007257 CcmE; Region: CcmE; cl00994 762376007258 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376007259 CcmB protein; Region: CcmB; cl01016 762376007260 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 762376007261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376007262 Walker A/P-loop; other site 762376007263 ATP binding site [chemical binding]; other site 762376007264 Q-loop/lid; other site 762376007265 ABC transporter signature motif; other site 762376007266 Walker B; other site 762376007267 D-loop; other site 762376007268 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 762376007269 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 762376007270 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 762376007271 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 762376007272 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 762376007273 [4Fe-4S] binding site [ion binding]; other site 762376007274 molybdopterin cofactor binding site; other site 762376007275 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 762376007276 molybdopterin cofactor binding site; other site 762376007277 NapD protein; Region: NapD; cl01163 762376007278 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 762376007279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007280 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376007281 putative effector binding pocket; other site 762376007282 dimerization interface [polypeptide binding]; other site 762376007283 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 762376007284 YadA-like C-terminal region; Region: YadA; pfam03895 762376007285 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 762376007286 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 762376007287 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 762376007288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007289 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376007290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007292 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376007293 putative dimerization interface [polypeptide binding]; other site 762376007294 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376007295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007296 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762376007297 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762376007298 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 762376007299 Ligand binding site [chemical binding]; other site 762376007300 metal binding site [ion binding]; metal-binding site 762376007301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376007302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376007303 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 762376007304 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-...; Region: CSHase; cd01015 762376007305 Isochorismatase family; Region: Isochorismatase; pfam00857 762376007306 substrate binding site [chemical binding]; other site 762376007307 catalytic triad [active] 762376007308 domain interfaces; other site 762376007309 conserved cis-peptide bond; other site 762376007310 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376007311 inter-subunit interface; other site 762376007312 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376007313 iron-sulfur cluster [ion binding]; other site 762376007314 [2Fe-2S] cluster binding site [ion binding]; other site 762376007315 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376007316 putative alpha subunit interface [polypeptide binding]; other site 762376007317 putative active site [active] 762376007318 putative substrate binding site [chemical binding]; other site 762376007319 Fe binding site [ion binding]; other site 762376007320 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376007321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007322 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 762376007323 [2Fe-2S] cluster binding site [ion binding]; other site 762376007324 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376007325 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762376007326 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 762376007327 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376007328 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 762376007329 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 762376007330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 762376007331 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762376007332 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 762376007333 putative hydrophobic ligand binding site [chemical binding]; other site 762376007334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007335 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376007336 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376007337 Walker A/P-loop; other site 762376007338 ATP binding site [chemical binding]; other site 762376007339 Q-loop/lid; other site 762376007340 ABC transporter signature motif; other site 762376007341 Walker B; other site 762376007342 D-loop; other site 762376007343 H-loop/switch region; other site 762376007344 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376007345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376007346 dimer interface [polypeptide binding]; other site 762376007347 conserved gate region; other site 762376007348 putative PBP binding loops; other site 762376007349 ABC-ATPase subunit interface; other site 762376007350 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376007351 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376007352 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376007353 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 762376007354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376007355 S-adenosylmethionine binding site [chemical binding]; other site 762376007356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376007357 S-adenosylmethionine binding site [chemical binding]; other site 762376007358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376007359 non-specific DNA binding site [nucleotide binding]; other site 762376007360 salt bridge; other site 762376007361 sequence-specific DNA binding site [nucleotide binding]; other site 762376007362 HipA N-terminal domain; Region: couple_hipA; TIGR03071 762376007363 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376007364 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376007365 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376007366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007368 DNA-binding site [nucleotide binding]; DNA binding site 762376007369 FCD domain; Region: FCD; cl11656 762376007370 Dehydratase family; Region: ILVD_EDD; cl00340 762376007371 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376007372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007374 RNase II stability modulator; Provisional; Region: PRK10060 762376007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376007376 putative active site [active] 762376007377 heme pocket [chemical binding]; other site 762376007378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007379 metal binding site [ion binding]; metal-binding site 762376007380 active site 762376007381 I-site; other site 762376007382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376007383 enoyl-CoA hydratase; Validated; Region: PRK08788 762376007384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376007385 substrate binding site [chemical binding]; other site 762376007386 oxyanion hole (OAH) forming residues; other site 762376007387 trimer interface [polypeptide binding]; other site 762376007388 short chain dehydrogenase; Provisional; Region: PRK12937 762376007389 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 762376007390 NADP binding site [chemical binding]; other site 762376007391 homodimer interface [polypeptide binding]; other site 762376007392 active site 762376007393 substrate binding site [chemical binding]; other site 762376007394 transcriptional regulator; Provisional; Region: PRK10632 762376007395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007396 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376007397 putative effector binding pocket; other site 762376007398 putative dimerization interface [polypeptide binding]; other site 762376007399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376007400 Citrate transporter; Region: CitMHS; pfam03600 762376007401 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 762376007402 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 762376007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007404 putative substrate translocation pore; other site 762376007405 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376007406 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376007407 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007409 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376007410 dimerization interface [polypeptide binding]; other site 762376007411 substrate binding pocket [chemical binding]; other site 762376007412 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 762376007413 nudix motif; other site 762376007414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376007417 dimerization interface [polypeptide binding]; other site 762376007418 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376007419 intersubunit interface [polypeptide binding]; other site 762376007420 active site 762376007421 Zn2+ binding site [ion binding]; other site 762376007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007423 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376007424 putative substrate translocation pore; other site 762376007425 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 762376007426 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 762376007427 putative catalytic residue [active] 762376007428 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 762376007429 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376007430 active sites [active] 762376007431 tetramer interface [polypeptide binding]; other site 762376007432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376007433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007434 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376007435 putative substrate translocation pore; other site 762376007436 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376007437 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376007438 active site 762376007439 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376007440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376007441 active site 762376007442 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376007443 urocanate hydratase; Provisional; Region: PRK05414 762376007444 urocanate hydratase; Region: hutU; TIGR01228 762376007445 Uncharacterized conserved protein [Function unknown]; Region: COG3535 762376007446 Protein of unknown function (DUF917); Region: DUF917; pfam06032 762376007447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007449 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376007450 putative dimerization interface [polypeptide binding]; other site 762376007451 allantoinase; Provisional; Region: PRK06189 762376007452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376007453 active site 762376007454 allantoate amidohydrolase; Reviewed; Region: PRK12890 762376007455 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376007456 active site 762376007457 metal binding site [ion binding]; metal-binding site 762376007458 dimer interface [polypeptide binding]; other site 762376007459 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376007460 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376007461 putative ligand binding site [chemical binding]; other site 762376007462 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376007463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007464 DNA-binding site [nucleotide binding]; DNA binding site 762376007465 UTRA domain; Region: UTRA; cl06649 762376007466 acyl-CoA synthetase; Validated; Region: PRK06164 762376007467 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007468 Putative cyclase; Region: Cyclase; cl00814 762376007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007471 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376007472 classical (c) SDRs; Region: SDR_c; cd05233 762376007473 NAD(P) binding site [chemical binding]; other site 762376007474 active site 762376007475 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376007476 conserved cys residue [active] 762376007477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376007478 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 762376007479 conserved cys residue [active] 762376007480 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376007481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007482 LysE type translocator; Region: LysE; cl00565 762376007483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376007484 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 762376007485 Walker A/P-loop; other site 762376007486 ATP binding site [chemical binding]; other site 762376007487 Q-loop/lid; other site 762376007488 ABC transporter signature motif; other site 762376007489 Walker B; other site 762376007490 D-loop; other site 762376007491 H-loop/switch region; other site 762376007492 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376007493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007494 DNA-binding site [nucleotide binding]; DNA binding site 762376007495 FCD domain; Region: FCD; cl11656 762376007496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376007497 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 762376007498 active site 762376007499 metal binding site [ion binding]; metal-binding site 762376007500 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 762376007501 active site 762376007502 metal binding site [ion binding]; metal-binding site 762376007503 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376007504 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376007505 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376007506 NAD binding site [chemical binding]; other site 762376007507 catalytic residues [active] 762376007508 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376007509 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376007510 putative ligand binding site [chemical binding]; other site 762376007511 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376007512 TM-ABC transporter signature motif; other site 762376007513 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376007514 TM-ABC transporter signature motif; other site 762376007515 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376007516 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376007517 Walker A/P-loop; other site 762376007518 ATP binding site [chemical binding]; other site 762376007519 Q-loop/lid; other site 762376007520 ABC transporter signature motif; other site 762376007521 Walker B; other site 762376007522 D-loop; other site 762376007523 H-loop/switch region; other site 762376007524 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376007525 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376007526 Walker A/P-loop; other site 762376007527 ATP binding site [chemical binding]; other site 762376007528 Q-loop/lid; other site 762376007529 ABC transporter signature motif; other site 762376007530 Walker B; other site 762376007531 D-loop; other site 762376007532 H-loop/switch region; other site 762376007533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376007534 classical (c) SDRs; Region: SDR_c; cd05233 762376007535 NAD(P) binding site [chemical binding]; other site 762376007536 active site 762376007537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376007538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376007539 dimerization interface [polypeptide binding]; other site 762376007540 putative DNA binding site [nucleotide binding]; other site 762376007541 putative Zn2+ binding site [ion binding]; other site 762376007542 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 762376007543 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376007544 putative NAD(P) binding site [chemical binding]; other site 762376007545 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376007546 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376007547 N-terminal plug; other site 762376007548 ligand-binding site [chemical binding]; other site 762376007549 fec operon regulator FecR; Reviewed; Region: PRK09774 762376007550 FecR protein; Region: FecR; pfam04773 762376007551 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376007552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376007553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376007554 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376007555 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376007556 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376007557 N-terminal plug; other site 762376007558 ligand-binding site [chemical binding]; other site 762376007559 fec operon regulator FecR; Reviewed; Region: PRK09774 762376007560 FecR protein; Region: FecR; pfam04773 762376007561 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376007562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376007563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376007564 Flavin Reductases; Region: FlaRed; cl00801 762376007565 methionine synthase; Provisional; Region: PRK01207 762376007566 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 762376007567 substrate binding site [chemical binding]; other site 762376007568 THF binding site; other site 762376007569 zinc-binding site [ion binding]; other site 762376007570 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 762376007571 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 762376007572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007573 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 762376007574 putative dimerization interface [polypeptide binding]; other site 762376007575 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 762376007576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376007577 ATP binding site [chemical binding]; other site 762376007578 DNA helicase, putative; Region: TIGR00376 762376007579 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376007580 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 762376007581 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376007582 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 762376007583 active site 762376007584 FMN binding site [chemical binding]; other site 762376007585 substrate binding site [chemical binding]; other site 762376007586 putative catalytic residue [active] 762376007587 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376007588 homotrimer interaction site [polypeptide binding]; other site 762376007589 putative active site [active] 762376007590 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007592 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376007593 dimerization interface [polypeptide binding]; other site 762376007594 substrate binding pocket [chemical binding]; other site 762376007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376007596 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376007597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007598 putative substrate translocation pore; other site 762376007599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007602 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 762376007603 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 762376007604 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 762376007605 active site 762376007606 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 762376007607 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 762376007608 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376007609 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 762376007610 Walker A/P-loop; other site 762376007611 ATP binding site [chemical binding]; other site 762376007612 Q-loop/lid; other site 762376007613 ABC transporter signature motif; other site 762376007614 Walker B; other site 762376007615 D-loop; other site 762376007616 H-loop/switch region; other site 762376007617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376007618 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376007619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376007620 Walker A/P-loop; other site 762376007621 ATP binding site [chemical binding]; other site 762376007622 Q-loop/lid; other site 762376007623 ABC transporter signature motif; other site 762376007624 Walker B; other site 762376007625 D-loop; other site 762376007626 H-loop/switch region; other site 762376007627 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 762376007628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007630 dimerization interface [polypeptide binding]; other site 762376007631 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007633 DNA-binding site [nucleotide binding]; DNA binding site 762376007634 FCD domain; Region: FCD; cl11656 762376007635 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 762376007636 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007637 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 762376007638 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376007639 active site 762376007640 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376007641 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376007642 Walker A/P-loop; other site 762376007643 ATP binding site [chemical binding]; other site 762376007644 Q-loop/lid; other site 762376007645 ABC transporter signature motif; other site 762376007646 Walker B; other site 762376007647 D-loop; other site 762376007648 H-loop/switch region; other site 762376007649 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376007650 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376007651 Walker A/P-loop; other site 762376007652 ATP binding site [chemical binding]; other site 762376007653 Q-loop/lid; other site 762376007654 ABC transporter signature motif; other site 762376007655 Walker B; other site 762376007656 D-loop; other site 762376007657 H-loop/switch region; other site 762376007658 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376007659 TM-ABC transporter signature motif; other site 762376007660 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376007661 TM-ABC transporter signature motif; other site 762376007662 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376007663 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376007664 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376007665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007667 dimerization interface [polypeptide binding]; other site 762376007668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007670 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376007671 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376007672 active site 762376007673 catalytic site [active] 762376007674 N-formylglutamate amidohydrolase; Region: FGase; cl01522 762376007675 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376007676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007677 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376007678 putative effector binding pocket; other site 762376007679 dimerization interface [polypeptide binding]; other site 762376007680 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376007681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 762376007682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376007683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376007684 MarC family integral membrane protein; Region: MarC; cl00919 762376007685 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 762376007686 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 762376007687 active site 762376007688 non-prolyl cis peptide bond; other site 762376007689 Sodium:solute symporter family; Region: SSF; cl00456 762376007690 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 762376007691 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007692 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376007693 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 762376007694 dimer interface [polypeptide binding]; other site 762376007695 active site 762376007696 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376007697 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376007698 putative ligand binding site [chemical binding]; other site 762376007699 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376007700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007702 dimerization interface [polypeptide binding]; other site 762376007703 transcriptional regulator TraR; Provisional; Region: PRK13870 762376007704 Autoinducer binding domain; Region: Autoind_bind; pfam03472 762376007705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376007706 DNA binding residues [nucleotide binding] 762376007707 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 762376007708 putative phosphate binding site [ion binding]; other site 762376007709 putative catalytic site [active] 762376007710 active site 762376007711 metal binding site A [ion binding]; metal-binding site 762376007712 DNA binding site [nucleotide binding] 762376007713 putative AP binding site [nucleotide binding]; other site 762376007714 putative metal binding site B [ion binding]; other site 762376007715 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 762376007716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376007717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376007718 MbtH-like protein; Region: MbtH; cl01279 762376007719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376007720 Thioesterase domain; Region: Thioesterase; pfam00975 762376007721 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762376007722 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 762376007723 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 762376007724 acyl-CoA synthetase; Validated; Region: PRK09192 762376007725 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007726 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007727 Condensation domain; Region: Condensation; cl09290 762376007728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376007729 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007730 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007731 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007732 Condensation domain; Region: Condensation; cl09290 762376007733 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376007734 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007735 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007736 Condensation domain; Region: Condensation; cl09290 762376007737 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 762376007738 Condensation domain; Region: Condensation; cl09290 762376007739 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376007740 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007741 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007742 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007743 Condensation domain; Region: Condensation; cl09290 762376007744 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376007745 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007746 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007747 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007748 Condensation domain; Region: Condensation; cl09290 762376007749 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 762376007750 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007751 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376007752 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007753 Thioesterase domain; Region: Thioesterase; pfam00975 762376007754 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376007755 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 762376007756 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 762376007757 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 762376007758 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 762376007759 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376007760 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376007761 N-terminal plug; other site 762376007762 ligand-binding site [chemical binding]; other site 762376007763 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376007764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376007765 N-terminal plug; other site 762376007766 ligand-binding site [chemical binding]; other site 762376007767 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 762376007768 catalytic site [active] 762376007769 Penicillin amidase; Region: Penicil_amidase; pfam01804 762376007770 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 762376007771 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 762376007772 active site 762376007773 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 762376007774 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 762376007775 Walker A/P-loop; other site 762376007776 ATP binding site [chemical binding]; other site 762376007777 Q-loop/lid; other site 762376007778 ABC transporter signature motif; other site 762376007779 Walker B; other site 762376007780 D-loop; other site 762376007781 H-loop/switch region; other site 762376007782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376007783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007784 NAD(P) binding site [chemical binding]; other site 762376007785 active site 762376007786 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007788 DNA-binding site [nucleotide binding]; DNA binding site 762376007789 FCD domain; Region: FCD; cl11656 762376007790 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376007791 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 762376007792 NAD(P) binding site [chemical binding]; other site 762376007793 catalytic residues [active] 762376007794 catalytic residues [active] 762376007795 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 762376007796 Lumazine binding domain; Region: Lum_binding; pfam00677 762376007797 Lumazine binding domain; Region: Lum_binding; pfam00677 762376007798 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 762376007799 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376007800 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376007801 MlrC C-terminus; Region: MlrC_C; pfam07171 762376007802 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007804 putative substrate translocation pore; other site 762376007805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007808 dimerization interface [polypeptide binding]; other site 762376007809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376007810 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376007811 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376007812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376007813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376007814 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 762376007815 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 762376007816 DNA binding residues [nucleotide binding] 762376007817 dimer interface [polypeptide binding]; other site 762376007818 putative metal binding site [ion binding]; other site 762376007819 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376007820 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007822 DNA-binding site [nucleotide binding]; DNA binding site 762376007823 FCD domain; Region: FCD; cl11656 762376007824 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376007825 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376007826 substrate binding site [chemical binding]; other site 762376007827 oxyanion hole (OAH) forming residues; other site 762376007828 trimer interface [polypeptide binding]; other site 762376007829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007830 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007831 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 762376007832 putative FMN binding site [chemical binding]; other site 762376007833 putative transposase OrfB; Reviewed; Region: PHA02517 762376007834 Integrase core domain; Region: rve; cl01316 762376007835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376007836 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 762376007837 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376007838 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376007839 tetramer interface [polypeptide binding]; other site 762376007840 TPP-binding site [chemical binding]; other site 762376007841 heterodimer interface [polypeptide binding]; other site 762376007842 phosphorylation loop region [posttranslational modification] 762376007843 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376007844 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376007845 alpha subunit interface [polypeptide binding]; other site 762376007846 TPP binding site [chemical binding]; other site 762376007847 heterodimer interface [polypeptide binding]; other site 762376007848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376007849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376007850 E3 interaction surface; other site 762376007851 lipoyl attachment site [posttranslational modification]; other site 762376007852 e3 binding domain; Region: E3_binding; pfam02817 762376007853 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376007854 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762376007855 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 762376007856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007858 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376007859 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376007860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007861 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376007862 dimerization interface [polypeptide binding]; other site 762376007863 substrate binding pocket [chemical binding]; other site 762376007864 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376007865 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376007866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007868 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376007869 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376007870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007872 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376007873 putative dimerization interface [polypeptide binding]; other site 762376007874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007876 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376007877 active site 762376007878 catalytic site [active] 762376007879 The beta subunit of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol; Region: 2A5CPDO_B; cd07372 762376007880 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376007881 putative active site [active] 762376007882 putative metal binding site [ion binding]; other site 762376007883 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 762376007884 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376007885 active site 762376007886 metal binding site [ion binding]; metal-binding site 762376007887 putative fumarate hydratase; Provisional; Region: PRK15392 762376007888 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 762376007889 Fumarase C-terminus; Region: Fumerase_C; cl00795 762376007890 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007892 putative substrate translocation pore; other site 762376007893 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 762376007894 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376007895 C-terminal domain interface [polypeptide binding]; other site 762376007896 GSH binding site (G-site) [chemical binding]; other site 762376007897 putative dimer interface [polypeptide binding]; other site 762376007898 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 762376007899 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 762376007900 N-terminal domain interface [polypeptide binding]; other site 762376007901 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376007902 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376007903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376007904 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376007905 Zn binding site [ion binding]; other site 762376007906 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376007907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376007908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376007909 DNA binding residues [nucleotide binding] 762376007910 dimerization interface [polypeptide binding]; other site 762376007911 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007913 putative substrate translocation pore; other site 762376007914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007916 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 762376007917 putative effector binding pocket; other site 762376007918 putative dimerization interface [polypeptide binding]; other site 762376007919 argininosuccinate lyase; Provisional; Region: PRK00855 762376007920 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762376007921 active sites [active] 762376007922 tetramer interface [polypeptide binding]; other site 762376007923 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376007924 NAD synthetase; Reviewed; Region: nadE; PRK02628 762376007925 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 762376007926 multimer interface [polypeptide binding]; other site 762376007927 active site 762376007928 catalytic triad [active] 762376007929 protein interface 1 [polypeptide binding]; other site 762376007930 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 762376007931 homodimer interface [polypeptide binding]; other site 762376007932 NAD binding pocket [chemical binding]; other site 762376007933 ATP binding pocket [chemical binding]; other site 762376007934 Mg binding site [ion binding]; other site 762376007935 active-site loop [active] 762376007936 Nitrogen regulatory protein P-II; Region: P-II; cl00412 762376007937 general secretion pathway protein F; Region: GspF; TIGR02120 762376007938 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762376007939 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762376007940 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 762376007941 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376007942 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376007943 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376007944 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376007945 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 762376007946 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 762376007947 Walker A motif; other site 762376007948 ATP binding site [chemical binding]; other site 762376007949 Walker B motif; other site 762376007950 Phd_YefM; Region: PhdYeFM; cl09153 762376007951 Bacterial type II secretion system protein N; Region: GSPII_N; pfam01203 762376007952 General secretion pathway, M protein; Region: GspM; cl01222 762376007953 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 762376007954 GspL periplasmic domain; Region: GspL_C; cl14909 762376007955 General secretion pathway protein K; Region: GspK; pfam03934 762376007956 Pseudopilin GspJ; Region: GspJ; pfam11612 762376007957 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 762376007958 Type II transport protein GspH; Region: GspH; pfam12019 762376007959 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 762376007960 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 762376007961 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 762376007962 Sulfatase; Region: Sulfatase; cl10460 762376007963 Pseudomonas-type; Region: PC_PLC; TIGR03396 762376007964 Phosphoesterase family; Region: Phosphoesterase; cl10627 762376007965 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376007966 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376007967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376007969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007970 dimerization interface [polypeptide binding]; other site 762376007971 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376007972 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376007973 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 762376007974 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376007975 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376007976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376007977 dimer interface [polypeptide binding]; other site 762376007978 conserved gate region; other site 762376007979 putative PBP binding loops; other site 762376007980 ABC-ATPase subunit interface; other site 762376007981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376007982 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762376007983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376007984 dimer interface [polypeptide binding]; other site 762376007985 conserved gate region; other site 762376007986 putative PBP binding loops; other site 762376007987 ABC-ATPase subunit interface; other site 762376007988 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376007989 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376007990 Walker A/P-loop; other site 762376007991 ATP binding site [chemical binding]; other site 762376007992 Q-loop/lid; other site 762376007993 ABC transporter signature motif; other site 762376007994 Walker B; other site 762376007995 D-loop; other site 762376007996 H-loop/switch region; other site 762376007997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376007998 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376007999 Walker A/P-loop; other site 762376008000 ATP binding site [chemical binding]; other site 762376008001 Q-loop/lid; other site 762376008002 ABC transporter signature motif; other site 762376008003 Walker B; other site 762376008004 D-loop; other site 762376008005 H-loop/switch region; other site 762376008006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376008007 LysE type translocator; Region: LysE; cl00565 762376008008 YaeQ protein; Region: YaeQ; cl01913 762376008009 PAS fold; Region: PAS_3; pfam08447 762376008010 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 762376008011 hypothetical protein; Provisional; Region: PRK13560 762376008012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376008013 metal binding site [ion binding]; metal-binding site 762376008014 active site 762376008015 I-site; other site 762376008016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376008017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008018 DNA-binding site [nucleotide binding]; DNA binding site 762376008019 UTRA domain; Region: UTRA; cl06649 762376008020 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008021 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 762376008022 putative ligand binding site [chemical binding]; other site 762376008023 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008024 TM-ABC transporter signature motif; other site 762376008025 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008026 TM-ABC transporter signature motif; other site 762376008027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008028 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376008029 Walker A/P-loop; other site 762376008030 ATP binding site [chemical binding]; other site 762376008031 Q-loop/lid; other site 762376008032 ABC transporter signature motif; other site 762376008033 Walker B; other site 762376008034 D-loop; other site 762376008035 H-loop/switch region; other site 762376008036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008037 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376008038 Walker A/P-loop; other site 762376008039 ATP binding site [chemical binding]; other site 762376008040 Q-loop/lid; other site 762376008041 ABC transporter signature motif; other site 762376008042 Walker B; other site 762376008043 D-loop; other site 762376008044 H-loop/switch region; other site 762376008045 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376008046 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 762376008047 substrate binding site [chemical binding]; other site 762376008048 ligand binding site [chemical binding]; other site 762376008049 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376008050 substrate binding site [chemical binding]; other site 762376008051 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762376008052 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 762376008053 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376008054 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 762376008055 Isochorismatase family; Region: Isochorismatase; pfam00857 762376008056 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376008057 catalytic triad [active] 762376008058 conserved cis-peptide bond; other site 762376008059 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 762376008060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008062 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376008063 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376008064 tetramer interface [polypeptide binding]; other site 762376008065 active site 762376008066 Mg2+/Mn2+ binding site [ion binding]; other site 762376008067 Chorismate lyase; Region: Chor_lyase; cl01230 762376008068 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376008069 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 762376008070 putative active site [active] 762376008071 catalytic triad [active] 762376008072 putative dimer interface [polypeptide binding]; other site 762376008073 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008074 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 762376008075 putative ligand binding site [chemical binding]; other site 762376008076 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008077 TM-ABC transporter signature motif; other site 762376008078 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008079 TM-ABC transporter signature motif; other site 762376008080 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008081 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376008082 Walker A/P-loop; other site 762376008083 ATP binding site [chemical binding]; other site 762376008084 Q-loop/lid; other site 762376008085 ABC transporter signature motif; other site 762376008086 Walker B; other site 762376008087 D-loop; other site 762376008088 H-loop/switch region; other site 762376008089 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008090 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376008091 Walker A/P-loop; other site 762376008092 ATP binding site [chemical binding]; other site 762376008093 Q-loop/lid; other site 762376008094 ABC transporter signature motif; other site 762376008095 Walker B; other site 762376008096 D-loop; other site 762376008097 H-loop/switch region; other site 762376008098 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 762376008099 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008100 ligand binding site [chemical binding]; other site 762376008101 regulator interaction site; other site 762376008102 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376008103 ANTAR domain; Region: ANTAR; pfam03861 762376008104 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376008105 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376008106 MlrC C-terminus; Region: MlrC_C; pfam07171 762376008107 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376008108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376008109 RNA binding surface [nucleotide binding]; other site 762376008110 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 762376008111 active site 762376008112 transcriptional regulator; Provisional; Region: PRK10632 762376008113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008114 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376008115 putative effector binding pocket; other site 762376008116 dimerization interface [polypeptide binding]; other site 762376008117 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 762376008118 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376008119 Protein export membrane protein; Region: SecD_SecF; cl14618 762376008120 NodT family; Region: outer_NodT; TIGR01845 762376008121 Outer membrane efflux protein; Region: OEP; pfam02321 762376008122 Outer membrane efflux protein; Region: OEP; pfam02321 762376008123 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 762376008124 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376008125 Cu(I) binding site [ion binding]; other site 762376008126 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 762376008127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376008128 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 762376008129 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 762376008130 active site 762376008131 Zn binding site [ion binding]; other site 762376008132 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 762376008133 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762376008134 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762376008135 homodimer interface [polypeptide binding]; other site 762376008136 NADP binding site [chemical binding]; other site 762376008137 substrate binding site [chemical binding]; other site 762376008138 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376008139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008140 active site 762376008141 phosphorylation site [posttranslational modification] 762376008142 intermolecular recognition site; other site 762376008143 dimerization interface [polypeptide binding]; other site 762376008144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376008145 DNA binding residues [nucleotide binding] 762376008146 dimerization interface [polypeptide binding]; other site 762376008147 7 transmembrane receptor (rhodopsin family); Region: 7tm_1; pfam00001 762376008148 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 762376008149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008150 putative active site [active] 762376008151 heme pocket [chemical binding]; other site 762376008152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376008153 dimer interface [polypeptide binding]; other site 762376008154 phosphorylation site [posttranslational modification] 762376008155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008156 ATP binding site [chemical binding]; other site 762376008157 Mg2+ binding site [ion binding]; other site 762376008158 G-X-G motif; other site 762376008159 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 762376008160 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376008161 dimer interface [polypeptide binding]; other site 762376008162 TPP-binding site [chemical binding]; other site 762376008163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008164 E3 interaction surface; other site 762376008165 lipoyl attachment site [posttranslational modification]; other site 762376008166 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008167 E3 interaction surface; other site 762376008168 lipoyl attachment site [posttranslational modification]; other site 762376008169 e3 binding domain; Region: E3_binding; pfam02817 762376008170 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376008171 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762376008172 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008173 E3 interaction surface; other site 762376008174 lipoyl attachment site [posttranslational modification]; other site 762376008175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008176 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 762376008177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008178 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376008179 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 762376008180 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 762376008181 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762376008182 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 762376008183 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 762376008184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376008185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762376008186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376008187 DNA binding residues [nucleotide binding] 762376008188 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 762376008189 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 762376008190 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 762376008191 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376008192 flagellar motor protein MotB; Validated; Region: motB; PRK09041 762376008193 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376008194 ligand binding site [chemical binding]; other site 762376008195 Response regulator receiver domain; Region: Response_reg; pfam00072 762376008196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008197 active site 762376008198 phosphorylation site [posttranslational modification] 762376008199 intermolecular recognition site; other site 762376008200 dimerization interface [polypeptide binding]; other site 762376008201 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762376008202 putative binding surface; other site 762376008203 active site 762376008204 CheY binding; Region: CheY-binding; pfam09078 762376008205 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 762376008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008207 ATP binding site [chemical binding]; other site 762376008208 Mg2+ binding site [ion binding]; other site 762376008209 G-X-G motif; other site 762376008210 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 762376008211 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 762376008212 putative CheA interaction surface; other site 762376008213 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376008214 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008215 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376008216 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008217 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008218 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 762376008219 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 762376008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376008221 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 762376008222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008223 active site 762376008224 phosphorylation site [posttranslational modification] 762376008225 intermolecular recognition site; other site 762376008226 dimerization interface [polypeptide binding]; other site 762376008227 CheB methylesterase; Region: CheB_methylest; pfam01339 762376008228 Response regulator receiver domain; Region: Response_reg; pfam00072 762376008229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008230 active site 762376008231 phosphorylation site [posttranslational modification] 762376008232 intermolecular recognition site; other site 762376008233 dimerization interface [polypeptide binding]; other site 762376008234 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 762376008235 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008236 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 762376008237 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 762376008238 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 762376008239 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 762376008240 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 762376008241 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 762376008242 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376008243 FlgN protein; Region: FlgN; cl09176 762376008244 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 762376008245 SAF domain; Region: SAF; cl00555 762376008246 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 762376008247 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 762376008248 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 762376008249 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 762376008250 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 762376008251 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 762376008252 Flagellar hook capping protein; Region: FlgD; cl04347 762376008253 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 762376008254 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 762376008255 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 762376008256 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 762376008257 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 762376008258 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 762376008259 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 762376008260 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 762376008261 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 762376008262 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 762376008263 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 762376008264 Flagellar L-ring protein; Region: FlgH; cl00905 762376008265 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 762376008266 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 762376008267 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 762376008268 Rod binding protein; Region: Rod-binding; cl01626 762376008269 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 762376008270 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 762376008271 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 762376008272 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 762376008273 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762376008274 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376008275 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008276 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376008277 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008278 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008279 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008280 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376008281 dimerization interface [polypeptide binding]; other site 762376008282 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008283 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008284 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008285 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376008286 dimerization interface [polypeptide binding]; other site 762376008287 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008288 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008290 PAS fold; Region: PAS_3; pfam08447 762376008291 putative active site [active] 762376008292 heme pocket [chemical binding]; other site 762376008293 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376008294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008295 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376008296 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 762376008297 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 762376008298 FliP family; Region: FliP; cl00593 762376008299 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 762376008300 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 762376008301 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 762376008302 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 762376008303 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 762376008304 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 762376008305 Flagellar FliJ protein; Region: FliJ; cl09161 762376008306 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 762376008307 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 762376008308 Walker A motif/ATP binding site; other site 762376008309 Walker B motif; other site 762376008310 flagellar assembly protein H; Validated; Region: fliH; PRK05687 762376008311 Flagellar assembly protein FliH; Region: FliH; pfam02108 762376008312 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 762376008313 FliG C-terminal domain; Region: FliG_C; pfam01706 762376008314 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 762376008315 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 762376008316 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 762376008317 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 762376008318 Flagellar regulator YcgR; Region: YcgR; pfam07317 762376008319 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 762376008320 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 762376008321 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 762376008322 Flagellar protein FliT; Region: FliT; cl05125 762376008323 Flagellar protein FliS; Region: FliS; cl00654 762376008324 flagellar capping protein; Reviewed; Region: fliD; PRK08032 762376008325 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 762376008326 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 762376008327 FlaG protein; Region: FlaG; cl00591 762376008328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008329 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376008330 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376008331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376008332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376008333 active site 762376008334 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376008335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008337 Cupin domain; Region: Cupin_2; cl09118 762376008338 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 762376008339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376008340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376008341 Sporulation related domain; Region: SPOR; cl10051 762376008342 Colicin V production protein; Region: Colicin_V; cl00567 762376008343 amidophosphoribosyltransferase; Provisional; Region: PRK09246 762376008344 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762376008345 active site 762376008346 tetramer interface [polypeptide binding]; other site 762376008347 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376008348 Protein of unknown function DUF45; Region: DUF45; cl00636 762376008349 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 762376008350 MarC family integral membrane protein; Region: MarC; cl00919 762376008351 PII uridylyl-transferase; Provisional; Region: PRK03059 762376008352 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376008353 metal binding triad; other site 762376008354 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376008355 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376008356 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 762376008357 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 762376008358 methionine aminopeptidase; Reviewed; Region: PRK07281 762376008359 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762376008360 active site 762376008361 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762376008362 rRNA interaction site [nucleotide binding]; other site 762376008363 S8 interaction site; other site 762376008364 putative laminin-1 binding site; other site 762376008365 elongation factor Ts; Provisional; Region: tsf; PRK09377 762376008366 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 762376008367 Elongation factor TS; Region: EF_TS; pfam00889 762376008368 Elongation factor TS; Region: EF_TS; pfam00889 762376008369 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 762376008370 putative nucleotide binding site [chemical binding]; other site 762376008371 uridine monophosphate binding site [chemical binding]; other site 762376008372 homohexameric interface [polypeptide binding]; other site 762376008373 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 762376008374 hinge region; other site 762376008375 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 762376008376 catalytic residue [active] 762376008377 putative FPP diphosphate binding site; other site 762376008378 putative FPP binding hydrophobic cleft; other site 762376008379 dimer interface [polypeptide binding]; other site 762376008380 putative IPP diphosphate binding site; other site 762376008381 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 762376008382 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 762376008383 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 762376008384 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 762376008385 zinc metallopeptidase RseP; Provisional; Region: PRK10779 762376008386 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762376008387 active site 762376008388 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 762376008389 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762376008390 putative substrate binding region [chemical binding]; other site 762376008391 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 762376008392 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376008393 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376008394 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376008395 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376008396 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376008397 Surface antigen; Region: Bac_surface_Ag; cl03097 762376008398 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 762376008399 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 762376008400 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 762376008401 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 762376008402 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 762376008403 trimer interface [polypeptide binding]; other site 762376008404 active site 762376008405 UDP-GlcNAc binding site [chemical binding]; other site 762376008406 lipid binding site [chemical binding]; lipid-binding site 762376008407 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762376008408 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 762376008409 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 762376008410 active site 762376008411 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 762376008412 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 762376008413 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762376008414 RNA/DNA hybrid binding site [nucleotide binding]; other site 762376008415 active site 762376008416 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762376008417 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762376008418 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 762376008419 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 762376008420 Domain of unknown function (DUF299); Region: DUF299; cl00780 762376008421 phosphoenolpyruvate synthase; Validated; Region: PRK06464 762376008422 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376008423 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 762376008424 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376008425 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 762376008426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376008427 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376008428 DNA binding site [nucleotide binding] 762376008429 active site 762376008430 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762376008431 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762376008432 catalytic triad [active] 762376008433 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762376008434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376008435 metal binding site [ion binding]; metal-binding site 762376008436 active site 762376008437 I-site; other site 762376008438 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762376008439 SmpB-tmRNA interface; other site 762376008440 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 762376008441 putative coenzyme Q binding site [chemical binding]; other site 762376008442 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 762376008443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376008444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376008445 active site 762376008446 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 762376008447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376008448 substrate binding site [chemical binding]; other site 762376008449 oxyanion hole (OAH) forming residues; other site 762376008450 trimer interface [polypeptide binding]; other site 762376008451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376008452 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 762376008453 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376008454 CoenzymeA binding site [chemical binding]; other site 762376008455 subunit interaction site [polypeptide binding]; other site 762376008456 PHB binding site; other site 762376008457 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762376008458 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 762376008459 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 762376008460 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762376008461 YceG-like family; Region: YceG; pfam02618 762376008462 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 762376008463 dimerization interface [polypeptide binding]; other site 762376008464 thymidylate kinase; Validated; Region: tmk; PRK00698 762376008465 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 762376008466 TMP-binding site; other site 762376008467 ATP-binding site [chemical binding]; other site 762376008468 DNA polymerase III subunit delta'; Validated; Region: PRK06964 762376008469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376008470 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 762376008471 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762376008472 active site 762376008473 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376008474 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376008475 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376008476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008477 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376008478 DNA-binding site [nucleotide binding]; DNA binding site 762376008479 FCD domain; Region: FCD; cl11656 762376008480 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 762376008481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376008482 inhibitor-cofactor binding pocket; inhibition site 762376008483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376008484 catalytic residue [active] 762376008485 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 762376008486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376008487 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376008488 substrate binding site [chemical binding]; other site 762376008489 oxyanion hole (OAH) forming residues; other site 762376008490 trimer interface [polypeptide binding]; other site 762376008491 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376008492 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 762376008493 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 762376008494 ligand binding site [chemical binding]; other site 762376008495 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008496 TM-ABC transporter signature motif; other site 762376008497 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008498 TM-ABC transporter signature motif; other site 762376008499 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008500 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376008501 Walker A/P-loop; other site 762376008502 ATP binding site [chemical binding]; other site 762376008503 Q-loop/lid; other site 762376008504 ABC transporter signature motif; other site 762376008505 Walker B; other site 762376008506 D-loop; other site 762376008507 H-loop/switch region; other site 762376008508 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008509 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376008510 Walker A/P-loop; other site 762376008511 ATP binding site [chemical binding]; other site 762376008512 Q-loop/lid; other site 762376008513 ABC transporter signature motif; other site 762376008514 Walker B; other site 762376008515 D-loop; other site 762376008516 H-loop/switch region; other site 762376008517 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376008518 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376008519 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376008520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008521 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376008522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376008523 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376008524 substrate binding pocket [chemical binding]; other site 762376008525 membrane-bound complex binding site; other site 762376008526 hinge residues; other site 762376008527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376008528 dimer interface [polypeptide binding]; other site 762376008529 conserved gate region; other site 762376008530 putative PBP binding loops; other site 762376008531 ABC-ATPase subunit interface; other site 762376008532 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376008533 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376008534 Walker A/P-loop; other site 762376008535 ATP binding site [chemical binding]; other site 762376008536 Q-loop/lid; other site 762376008537 ABC transporter signature motif; other site 762376008538 Walker B; other site 762376008539 D-loop; other site 762376008540 H-loop/switch region; other site 762376008541 Arginase family; Region: Arginase; cl00306 762376008542 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 762376008543 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 762376008544 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 762376008545 NAD(P) binding site [chemical binding]; other site 762376008546 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376008547 trimer interface [polypeptide binding]; other site 762376008548 eyelet of channel; other site 762376008549 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 762376008550 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 762376008551 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762376008552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376008553 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 762376008554 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 762376008555 C-terminal domain interface [polypeptide binding]; other site 762376008556 GSH binding site (G-site) [chemical binding]; other site 762376008557 dimer interface [polypeptide binding]; other site 762376008558 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 762376008559 dimer interface [polypeptide binding]; other site 762376008560 N-terminal domain interface [polypeptide binding]; other site 762376008561 putative substrate binding pocket (H-site) [chemical binding]; other site 762376008562 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376008563 EamA-like transporter family; Region: EamA; cl01037 762376008564 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 762376008565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008566 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 762376008567 catalytic residues [active] 762376008568 dimer interface [polypeptide binding]; other site 762376008569 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376008570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008571 putative substrate translocation pore; other site 762376008572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376008573 TPR motif; other site 762376008574 binding surface 762376008575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008576 PAS fold; Region: PAS_3; pfam08447 762376008577 putative active site [active] 762376008578 heme pocket [chemical binding]; other site 762376008579 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 762376008580 DNA photolyase; Region: DNA_photolyase; pfam00875 762376008581 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 762376008582 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376008583 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 762376008584 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 762376008585 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 762376008586 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 762376008587 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 762376008588 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 762376008589 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 762376008590 catalytic triad [active] 762376008591 DoxX; Region: DoxX; cl00976 762376008592 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 762376008593 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762376008594 ATP binding site [chemical binding]; other site 762376008595 Mg++ binding site [ion binding]; other site 762376008596 motif III; other site 762376008597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376008598 nucleotide binding region [chemical binding]; other site 762376008599 ATP-binding site [chemical binding]; other site 762376008600 DbpA RNA binding domain; Region: DbpA; pfam03880 762376008601 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376008602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008603 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376008604 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 762376008605 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376008606 PYR/PP interface [polypeptide binding]; other site 762376008607 dimer interface [polypeptide binding]; other site 762376008608 TPP binding site [chemical binding]; other site 762376008609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376008610 TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl...; Region: TPP_Xsc_like; cd02013 762376008611 TPP-binding site; other site 762376008612 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376008613 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762376008614 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376008615 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376008616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376008617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376008618 dimer interface [polypeptide binding]; other site 762376008619 conserved gate region; other site 762376008620 putative PBP binding loops; other site 762376008621 ABC-ATPase subunit interface; other site 762376008622 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 762376008623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376008624 dimer interface [polypeptide binding]; other site 762376008625 conserved gate region; other site 762376008626 putative PBP binding loops; other site 762376008627 ABC-ATPase subunit interface; other site 762376008628 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376008629 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376008630 Walker A/P-loop; other site 762376008631 ATP binding site [chemical binding]; other site 762376008632 Q-loop/lid; other site 762376008633 ABC transporter signature motif; other site 762376008634 Walker B; other site 762376008635 D-loop; other site 762376008636 H-loop/switch region; other site 762376008637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376008638 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376008639 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376008640 Walker A/P-loop; other site 762376008641 ATP binding site [chemical binding]; other site 762376008642 Q-loop/lid; other site 762376008643 ABC transporter signature motif; other site 762376008644 Walker B; other site 762376008645 D-loop; other site 762376008646 H-loop/switch region; other site 762376008647 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376008648 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376008649 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376008650 active site 762376008651 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376008652 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376008653 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 762376008654 classical (c) SDRs; Region: SDR_c; cd05233 762376008655 NAD(P) binding site [chemical binding]; other site 762376008656 active site 762376008657 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376008658 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376008659 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376008660 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376008661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008662 DNA-binding site [nucleotide binding]; DNA binding site 762376008663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376008664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376008665 homodimer interface [polypeptide binding]; other site 762376008666 catalytic residue [active] 762376008667 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376008668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376008669 dimer interface [polypeptide binding]; other site 762376008670 conserved gate region; other site 762376008671 putative PBP binding loops; other site 762376008672 ABC-ATPase subunit interface; other site 762376008673 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 762376008674 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376008675 Walker A/P-loop; other site 762376008676 ATP binding site [chemical binding]; other site 762376008677 Q-loop/lid; other site 762376008678 ABC transporter signature motif; other site 762376008679 Walker B; other site 762376008680 D-loop; other site 762376008681 H-loop/switch region; other site 762376008682 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376008683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376008684 substrate binding pocket [chemical binding]; other site 762376008685 membrane-bound complex binding site; other site 762376008686 hinge residues; other site 762376008687 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 762376008688 homodecamer interface [polypeptide binding]; other site 762376008689 GTP cyclohydrolase I; Provisional; Region: PLN03044 762376008690 active site 762376008691 putative catalytic site residues [active] 762376008692 zinc binding site [ion binding]; other site 762376008693 GTP-CH-I/GFRP interaction surface; other site 762376008694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376008695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008696 active site 762376008697 phosphorylation site [posttranslational modification] 762376008698 intermolecular recognition site; other site 762376008699 dimerization interface [polypeptide binding]; other site 762376008700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376008701 DNA binding residues [nucleotide binding] 762376008702 dimerization interface [polypeptide binding]; other site 762376008703 Cache domain; Region: Cache_2; pfam08269 762376008704 Histidine kinase; Region: HisKA_3; pfam07730 762376008705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 762376008706 Carbon starvation protein CstA; Region: CstA; cl00856 762376008707 Protein of unknown function (DUF466); Region: DUF466; cl01082 762376008708 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 762376008709 MFS_1 like family; Region: MFS_1_like; pfam12832 762376008710 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762376008711 Ferritin-like domain; Region: Ferritin; pfam00210 762376008712 dimerization interface [polypeptide binding]; other site 762376008713 DPS ferroxidase diiron center [ion binding]; other site 762376008714 ion pore; other site 762376008715 LysE type translocator; Region: LysE; cl00565 762376008716 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 762376008717 SelR domain; Region: SelR; cl00369 762376008718 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 762376008719 Moco binding site; other site 762376008720 metal coordination site [ion binding]; other site 762376008721 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 762376008722 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376008723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008724 active site 762376008725 phosphorylation site [posttranslational modification] 762376008726 intermolecular recognition site; other site 762376008727 dimerization interface [polypeptide binding]; other site 762376008728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376008729 DNA binding site [nucleotide binding] 762376008730 sensory histidine kinase CreC; Provisional; Region: PRK11100 762376008731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376008732 dimer interface [polypeptide binding]; other site 762376008733 phosphorylation site [posttranslational modification] 762376008734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008735 ATP binding site [chemical binding]; other site 762376008736 Mg2+ binding site [ion binding]; other site 762376008737 G-X-G motif; other site 762376008738 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376008739 phosphoenolpyruvate synthase; Validated; Region: PRK06241 762376008740 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 762376008741 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 762376008742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376008743 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376008744 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376008745 FMN binding site [chemical binding]; other site 762376008746 substrate binding site [chemical binding]; other site 762376008747 putative catalytic residue [active] 762376008748 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 762376008749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376008750 FeS/SAM binding site; other site 762376008751 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 762376008752 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 762376008753 ATP cone domain; Region: ATP-cone; pfam03477 762376008754 Class III ribonucleotide reductase; Region: RNR_III; cd01675 762376008755 effector binding site; other site 762376008756 active site 762376008757 Zn binding site [ion binding]; other site 762376008758 glycine loop; other site 762376008759 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 762376008760 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376008761 hydroperoxidase II; Provisional; Region: katE; PRK11249 762376008762 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 762376008763 heme binding pocket [chemical binding]; other site 762376008764 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 762376008765 domain interactions; other site 762376008766 Family of unknown function (DUF500); Region: DUF500; cl01109 762376008767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008769 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 762376008770 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 762376008771 metal binding site [ion binding]; metal-binding site 762376008772 putative dimer interface [polypeptide binding]; other site 762376008773 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376008774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008776 dimerization interface [polypeptide binding]; other site 762376008777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008779 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 762376008780 hypothetical protein; Provisional; Region: PRK09897 762376008781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008782 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376008783 active site 762376008784 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 762376008785 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376008786 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376008787 Zn binding site [ion binding]; other site 762376008788 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 762376008789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376008790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008791 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376008792 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376008793 active site 762376008794 catalytic residues [active] 762376008795 metal binding site [ion binding]; metal-binding site 762376008796 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376008797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008799 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 762376008800 Protein export membrane protein; Region: SecD_SecF; cl14618 762376008801 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 762376008802 Protein export membrane protein; Region: SecD_SecF; cl14618 762376008803 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 762376008804 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376008805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376008806 DNA binding residues [nucleotide binding] 762376008807 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376008808 FecR protein; Region: FecR; pfam04773 762376008809 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376008810 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376008811 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376008812 N-terminal plug; other site 762376008813 ligand-binding site [chemical binding]; other site 762376008814 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376008815 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376008816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008817 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376008818 dimerization interface [polypeptide binding]; other site 762376008819 putative effector binding pocket; other site 762376008820 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 762376008821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376008822 Low affinity iron permease; Region: Iron_permease; cl12096 762376008823 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376008824 NnrS protein; Region: NnrS; cl01258 762376008825 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 762376008826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008827 putative substrate translocation pore; other site 762376008828 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 762376008829 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 762376008830 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 762376008831 [4Fe-4S] binding site [ion binding]; other site 762376008832 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376008833 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376008834 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 762376008835 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 762376008836 molybdopterin cofactor binding site; other site 762376008837 nitrate reductase, beta subunit; Region: narH; TIGR01660 762376008838 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cl00470 762376008839 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 762376008840 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 762376008841 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376008842 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762376008843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376008844 FeS/SAM binding site; other site 762376008845 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762376008846 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 762376008847 active site clefts [active] 762376008848 zinc binding site [ion binding]; other site 762376008849 dimer interface [polypeptide binding]; other site 762376008850 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 762376008851 Walker A motif; other site 762376008852 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 762376008853 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376008854 dimerization interface [polypeptide binding]; other site 762376008855 GAF domain; Region: GAF; cl00853 762376008856 Histidine kinase; Region: HisKA_3; pfam07730 762376008857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008858 ATP binding site [chemical binding]; other site 762376008859 Mg2+ binding site [ion binding]; other site 762376008860 G-X-G motif; other site 762376008861 transcriptional regulator NarL; Provisional; Region: PRK10651 762376008862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376008863 active site 762376008864 phosphorylation site [posttranslational modification] 762376008865 intermolecular recognition site; other site 762376008866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376008867 DNA binding residues [nucleotide binding] 762376008868 dimerization interface [polypeptide binding]; other site 762376008869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008871 choline dehydrogenase; Validated; Region: PRK02106 762376008872 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376008873 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762376008874 TPP-binding site [chemical binding]; other site 762376008875 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376008876 PYR/PP interface [polypeptide binding]; other site 762376008877 dimer interface [polypeptide binding]; other site 762376008878 TPP binding site [chemical binding]; other site 762376008879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008881 dimerization interface [polypeptide binding]; other site 762376008882 Peptidase family U32; Region: Peptidase_U32; cl03113 762376008883 Peptidase family U32; Region: Peptidase_U32; cl03113 762376008884 SCP-2 sterol transfer family; Region: SCP2; cl01225 762376008885 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762376008886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376008887 NAD(P) binding site [chemical binding]; other site 762376008888 active site 762376008889 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 762376008890 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376008891 homodimer interface [polypeptide binding]; other site 762376008892 substrate-cofactor binding pocket; other site 762376008893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376008894 catalytic residue [active] 762376008895 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376008896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008897 DNA-binding site [nucleotide binding]; DNA binding site 762376008898 FCD domain; Region: FCD; cl11656 762376008899 Dehydratase family; Region: ILVD_EDD; cl00340 762376008900 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376008901 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 762376008902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008906 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376008907 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376008908 inhibitor site; inhibition site 762376008909 active site 762376008910 dimer interface [polypeptide binding]; other site 762376008911 catalytic residue [active] 762376008912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008913 DNA-binding site [nucleotide binding]; DNA binding site 762376008914 FCD domain; Region: FCD; cl11656 762376008915 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376008916 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 762376008917 FMN-binding pocket [chemical binding]; other site 762376008918 flavin binding motif; other site 762376008919 phosphate binding motif [ion binding]; other site 762376008920 beta-alpha-beta structure motif; other site 762376008921 NAD binding pocket [chemical binding]; other site 762376008922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376008923 catalytic loop [active] 762376008924 iron binding site [ion binding]; other site 762376008925 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376008926 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376008927 iron-sulfur cluster [ion binding]; other site 762376008928 [2Fe-2S] cluster binding site [ion binding]; other site 762376008929 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 762376008930 alpha subunit interface [polypeptide binding]; other site 762376008931 active site 762376008932 substrate binding site [chemical binding]; other site 762376008933 Fe binding site [ion binding]; other site 762376008934 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008935 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376008936 putative ligand binding site [chemical binding]; other site 762376008937 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 762376008938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008939 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376008940 substrate binding pocket [chemical binding]; other site 762376008941 dimerization interface [polypeptide binding]; other site 762376008942 Uncharacterized conserved protein [Function unknown]; Region: COG4104 762376008943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008945 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376008946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008948 dimerization interface [polypeptide binding]; other site 762376008949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376008952 dimerization interface [polypeptide binding]; other site 762376008953 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376008954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376008957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376008958 active site 762376008959 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376008960 classical (c) SDRs; Region: SDR_c; cd05233 762376008961 NAD(P) binding site [chemical binding]; other site 762376008962 active site 762376008963 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376008964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376008965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376008966 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 762376008967 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 762376008968 NmrA-like family; Region: NmrA; pfam05368 762376008969 NADP binding site [chemical binding]; other site 762376008970 active site 762376008971 regulatory binding site [polypeptide binding]; other site 762376008972 transcriptional regulator; Provisional; Region: PRK10632 762376008973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376008974 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376008975 putative effector binding pocket; other site 762376008976 dimerization interface [polypeptide binding]; other site 762376008977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376008978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 762376008979 dimer interface [polypeptide binding]; other site 762376008980 metal binding site [ion binding]; metal-binding site 762376008981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376008982 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 762376008983 putative ADP-ribose binding site [chemical binding]; other site 762376008984 putative active site [active] 762376008985 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43...; Region: PL2_Passenger_AT; cd01344 762376008986 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376008987 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376008988 short chain dehydrogenase; Provisional; Region: PRK12746 762376008989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376008990 NAD(P) binding site [chemical binding]; other site 762376008991 active site 762376008992 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376008993 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376008994 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376008995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376008996 dimer interface [polypeptide binding]; other site 762376008997 conserved gate region; other site 762376008998 putative PBP binding loops; other site 762376008999 ABC-ATPase subunit interface; other site 762376009000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376009001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009002 dimer interface [polypeptide binding]; other site 762376009003 conserved gate region; other site 762376009004 putative PBP binding loops; other site 762376009005 ABC-ATPase subunit interface; other site 762376009006 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376009007 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376009008 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376009009 CoenzymeA binding site [chemical binding]; other site 762376009010 subunit interaction site [polypeptide binding]; other site 762376009011 PHB binding site; other site 762376009012 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376009013 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376009014 NAD(P) binding site [chemical binding]; other site 762376009015 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_6; cd06233 762376009016 putative active site [active] 762376009017 Zn-binding site [ion binding]; other site 762376009018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376009019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376009020 substrate binding pocket [chemical binding]; other site 762376009021 membrane-bound complex binding site; other site 762376009022 hinge residues; other site 762376009023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009024 dimer interface [polypeptide binding]; other site 762376009025 conserved gate region; other site 762376009026 putative PBP binding loops; other site 762376009027 ABC-ATPase subunit interface; other site 762376009028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376009029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009030 dimer interface [polypeptide binding]; other site 762376009031 conserved gate region; other site 762376009032 putative PBP binding loops; other site 762376009033 ABC-ATPase subunit interface; other site 762376009034 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376009035 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376009036 Walker A/P-loop; other site 762376009037 ATP binding site [chemical binding]; other site 762376009038 Q-loop/lid; other site 762376009039 ABC transporter signature motif; other site 762376009040 Walker B; other site 762376009041 D-loop; other site 762376009042 H-loop/switch region; other site 762376009043 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762376009044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376009045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376009046 catalytic residue [active] 762376009047 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376009048 active site 762376009049 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 762376009050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009051 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 762376009052 substrate binding site [chemical binding]; other site 762376009053 dimerization interface [polypeptide binding]; other site 762376009054 Cysteine dioxygenase type I; Region: CDO_I; cl02350 762376009055 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009056 active site residue [active] 762376009057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009058 active site residue [active] 762376009059 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009060 active site residue [active] 762376009061 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009062 active site residue [active] 762376009063 Domain of unknown function (DUF336); Region: DUF336; cl01249 762376009064 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376009065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009066 active site 762376009067 phosphorylation site [posttranslational modification] 762376009068 intermolecular recognition site; other site 762376009069 dimerization interface [polypeptide binding]; other site 762376009070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376009071 DNA binding residues [nucleotide binding] 762376009072 dimerization interface [polypeptide binding]; other site 762376009073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376009074 dimer interface [polypeptide binding]; other site 762376009075 phosphorylation site [posttranslational modification] 762376009076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009077 ATP binding site [chemical binding]; other site 762376009078 Mg2+ binding site [ion binding]; other site 762376009079 G-X-G motif; other site 762376009080 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 762376009081 HPP family; Region: HPP; pfam04982 762376009082 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 762376009083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009084 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762376009085 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 762376009086 Cl- selectivity filter; other site 762376009087 Cl- binding residues [ion binding]; other site 762376009088 pore gating glutamate residue; other site 762376009089 dimer interface [polypeptide binding]; other site 762376009090 FOG: CBS domain [General function prediction only]; Region: COG0517 762376009091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 762376009092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376009095 dimerization interface [polypeptide binding]; other site 762376009096 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 762376009097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009098 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 762376009099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009100 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376009101 substrate binding pocket [chemical binding]; other site 762376009102 dimerization interface [polypeptide binding]; other site 762376009103 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376009104 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376009105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009106 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376009107 putative substrate translocation pore; other site 762376009108 lipid-transfer protein; Provisional; Region: PRK07855 762376009109 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376009110 active site 762376009111 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 762376009112 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376009113 catalytic residues [active] 762376009114 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009116 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376009117 hypothetical protein; Validated; Region: PRK07586 762376009118 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009119 PYR/PP interface [polypeptide binding]; other site 762376009120 dimer interface [polypeptide binding]; other site 762376009121 TPP binding site [chemical binding]; other site 762376009122 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 762376009123 TPP-binding site [chemical binding]; other site 762376009124 dimer interface [polypeptide binding]; other site 762376009125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376009126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009127 NAD(P) binding site [chemical binding]; other site 762376009128 active site 762376009129 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 762376009130 Ycf48-like protein; Provisional; Region: PRK13684 762376009131 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 762376009132 putative active site [active] 762376009133 putative metal binding site [ion binding]; other site 762376009134 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 762376009135 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376009136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376009137 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376009138 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 762376009139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376009140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376009141 Sulfatase; Region: Sulfatase; cl10460 762376009142 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376009143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376009146 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376009147 substrate binding pocket [chemical binding]; other site 762376009148 membrane-bound complex binding site; other site 762376009149 hinge residues; other site 762376009150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009151 dimer interface [polypeptide binding]; other site 762376009152 conserved gate region; other site 762376009153 putative PBP binding loops; other site 762376009154 ABC-ATPase subunit interface; other site 762376009155 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376009156 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376009157 Walker A/P-loop; other site 762376009158 ATP binding site [chemical binding]; other site 762376009159 Q-loop/lid; other site 762376009160 ABC transporter signature motif; other site 762376009161 Walker B; other site 762376009162 D-loop; other site 762376009163 H-loop/switch region; other site 762376009164 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376009165 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376009166 Walker A/P-loop; other site 762376009167 ATP binding site [chemical binding]; other site 762376009168 Q-loop/lid; other site 762376009169 ABC transporter signature motif; other site 762376009170 Walker B; other site 762376009171 D-loop; other site 762376009172 H-loop/switch region; other site 762376009173 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762376009174 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762376009175 ABC-ATPase subunit interface; other site 762376009176 dimer interface [polypeptide binding]; other site 762376009177 putative PBP binding regions; other site 762376009178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762376009179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762376009180 dimer interface [polypeptide binding]; other site 762376009181 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 762376009182 intersubunit interface [polypeptide binding]; other site 762376009183 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376009184 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009185 N-terminal plug; other site 762376009186 ligand-binding site [chemical binding]; other site 762376009187 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 762376009188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009189 putative substrate translocation pore; other site 762376009190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376009191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376009192 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376009193 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376009194 iron-sulfur cluster [ion binding]; other site 762376009195 [2Fe-2S] cluster binding site [ion binding]; other site 762376009196 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 762376009197 alpha subunit interface [polypeptide binding]; other site 762376009198 active site 762376009199 substrate binding site [chemical binding]; other site 762376009200 Fe binding site [ion binding]; other site 762376009201 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 762376009202 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 762376009203 IucA / IucC family; Region: IucA_IucC; pfam04183 762376009204 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 762376009205 Siderophore biosynthesis protein domain; Region: AlcB; pfam10331 762376009206 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376009207 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 762376009208 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376009209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009210 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376009211 dimerization interface [polypeptide binding]; other site 762376009212 substrate binding pocket [chemical binding]; other site 762376009213 NodT family; Region: outer_NodT; TIGR01845 762376009214 multidrug efflux protein; Reviewed; Region: PRK09579 762376009215 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376009216 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 762376009217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762376009218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376009219 Walker A/P-loop; other site 762376009220 ATP binding site [chemical binding]; other site 762376009221 Q-loop/lid; other site 762376009222 ABC transporter signature motif; other site 762376009223 Walker B; other site 762376009224 D-loop; other site 762376009225 H-loop/switch region; other site 762376009226 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 762376009227 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376009228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 762376009229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376009230 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376009231 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 762376009232 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 762376009233 threonine dehydratase; Reviewed; Region: PRK09224 762376009234 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376009235 tetramer interface [polypeptide binding]; other site 762376009236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009237 catalytic residue [active] 762376009238 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 762376009239 putative Ile/Val binding site [chemical binding]; other site 762376009240 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 762376009241 putative Ile/Val binding site [chemical binding]; other site 762376009242 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 762376009243 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376009244 putative active site [active] 762376009245 catalytic residue [active] 762376009246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009248 Fic family protein [Function unknown]; Region: COG3177 762376009249 Fic/DOC family; Region: Fic; cl00960 762376009250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009252 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376009253 putative dimerization interface [polypeptide binding]; other site 762376009254 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376009255 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009256 PYR/PP interface [polypeptide binding]; other site 762376009257 dimer interface [polypeptide binding]; other site 762376009258 TPP binding site [chemical binding]; other site 762376009259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376009260 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376009261 TPP-binding site [chemical binding]; other site 762376009262 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376009263 intersubunit interface [polypeptide binding]; other site 762376009264 active site 762376009265 Zn2+ binding site [ion binding]; other site 762376009266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009267 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009268 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 762376009269 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 762376009270 NAD(P) binding site [chemical binding]; other site 762376009271 catalytic residues [active] 762376009272 allantoate amidohydrolase; Reviewed; Region: PRK12893 762376009273 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376009274 active site 762376009275 metal binding site [ion binding]; metal-binding site 762376009276 dimer interface [polypeptide binding]; other site 762376009277 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376009278 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009279 PYR/PP interface [polypeptide binding]; other site 762376009280 dimer interface [polypeptide binding]; other site 762376009281 TPP binding site [chemical binding]; other site 762376009282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376009283 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376009284 TPP-binding site [chemical binding]; other site 762376009285 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376009286 DctM-like transporters; Region: DctM; pfam06808 762376009287 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376009288 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376009289 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376009290 Uncharacterized conserved protein [Function unknown]; Region: COG3391 762376009291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762376009292 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376009293 Walker A/P-loop; other site 762376009294 ATP binding site [chemical binding]; other site 762376009295 Q-loop/lid; other site 762376009296 ABC transporter signature motif; other site 762376009297 Walker B; other site 762376009298 D-loop; other site 762376009299 H-loop/switch region; other site 762376009300 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376009301 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376009302 Walker A/P-loop; other site 762376009303 ATP binding site [chemical binding]; other site 762376009304 Q-loop/lid; other site 762376009305 ABC transporter signature motif; other site 762376009306 Walker B; other site 762376009307 D-loop; other site 762376009308 H-loop/switch region; other site 762376009309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376009310 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376009311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009312 dimer interface [polypeptide binding]; other site 762376009313 conserved gate region; other site 762376009314 putative PBP binding loops; other site 762376009315 ABC-ATPase subunit interface; other site 762376009316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009317 dimer interface [polypeptide binding]; other site 762376009318 conserved gate region; other site 762376009319 putative PBP binding loops; other site 762376009320 ABC-ATPase subunit interface; other site 762376009321 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 762376009322 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376009323 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376009324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009325 DNA-binding site [nucleotide binding]; DNA binding site 762376009326 FCD domain; Region: FCD; cl11656 762376009327 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762376009328 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 762376009329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376009330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009331 active site 762376009332 phosphorylation site [posttranslational modification] 762376009333 intermolecular recognition site; other site 762376009334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376009335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009337 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376009338 putative dimerization interface [polypeptide binding]; other site 762376009339 Cupin domain; Region: Cupin_2; cl09118 762376009340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009342 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 762376009343 Active site [active] 762376009344 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376009345 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376009346 NAD(P) binding site [chemical binding]; other site 762376009347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009349 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376009350 trimer interface [polypeptide binding]; other site 762376009351 eyelet of channel; other site 762376009352 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 762376009353 putative active site [active] 762376009354 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376009355 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376009356 active site 762376009357 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376009358 Sulfatase; Region: Sulfatase; cl10460 762376009359 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 762376009360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009361 DNA-binding site [nucleotide binding]; DNA binding site 762376009362 FCD domain; Region: FCD; cl11656 762376009363 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 762376009364 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376009365 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376009366 FAD binding domain; Region: FAD_binding_3; pfam01494 762376009367 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376009368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376009369 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376009370 active site 762376009371 metal binding site [ion binding]; metal-binding site 762376009372 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 762376009373 putative active site [active] 762376009374 putative metal binding site [ion binding]; other site 762376009375 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376009376 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376009377 putative effector binding pocket; other site 762376009378 putative dimerization interface [polypeptide binding]; other site 762376009379 Isochorismatase family; Region: Isochorismatase; pfam00857 762376009380 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 762376009381 catalytic triad [active] 762376009382 dimer interface [polypeptide binding]; other site 762376009383 conserved cis-peptide bond; other site 762376009384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009385 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376009386 dimerization interface [polypeptide binding]; other site 762376009387 substrate binding pocket [chemical binding]; other site 762376009388 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376009389 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 762376009390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009391 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376009392 putative substrate translocation pore; other site 762376009393 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376009394 classical (c) SDRs; Region: SDR_c; cd05233 762376009395 NAD(P) binding site [chemical binding]; other site 762376009396 active site 762376009397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376009398 classical (c) SDRs; Region: SDR_c; cd05233 762376009399 NAD(P) binding site [chemical binding]; other site 762376009400 active site 762376009401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376009402 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376009403 Walker A/P-loop; other site 762376009404 ATP binding site [chemical binding]; other site 762376009405 Q-loop/lid; other site 762376009406 ABC transporter signature motif; other site 762376009407 Walker B; other site 762376009408 D-loop; other site 762376009409 H-loop/switch region; other site 762376009410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376009411 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376009412 Walker A/P-loop; other site 762376009413 ATP binding site [chemical binding]; other site 762376009414 Q-loop/lid; other site 762376009415 ABC transporter signature motif; other site 762376009416 Walker B; other site 762376009417 D-loop; other site 762376009418 H-loop/switch region; other site 762376009419 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376009420 TM-ABC transporter signature motif; other site 762376009421 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376009422 TM-ABC transporter signature motif; other site 762376009423 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009424 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 762376009425 putative ligand binding site [chemical binding]; other site 762376009426 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 762376009427 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 762376009428 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 762376009429 active site 762376009430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376009431 sulfite oxidase; Provisional; Region: PLN00177 762376009432 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 762376009433 Moco binding site; other site 762376009434 metal coordination site [ion binding]; other site 762376009435 dimerization interface [polypeptide binding]; other site 762376009436 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 762376009437 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376009438 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009439 N-terminal plug; other site 762376009440 ligand-binding site [chemical binding]; other site 762376009441 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376009442 FecR protein; Region: FecR; pfam04773 762376009443 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376009444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376009445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376009446 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376009447 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376009448 NodT family; Region: outer_NodT; TIGR01845 762376009449 Outer membrane efflux protein; Region: OEP; pfam02321 762376009450 Outer membrane efflux protein; Region: OEP; pfam02321 762376009451 cell division protein MukB; Provisional; Region: mukB; PRK04863 762376009452 putative mechanosensitive channel protein; Provisional; Region: PRK11465 762376009453 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376009454 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 762376009455 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 762376009456 dimerization domain [polypeptide binding]; other site 762376009457 dimer interface [polypeptide binding]; other site 762376009458 catalytic residues [active] 762376009459 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 762376009460 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376009461 catalytic residues [active] 762376009462 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 762376009463 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 762376009464 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 762376009465 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 762376009466 DsbD alpha interface [polypeptide binding]; other site 762376009467 catalytic residues [active] 762376009468 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 762376009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009470 active site 762376009471 phosphorylation site [posttranslational modification] 762376009472 intermolecular recognition site; other site 762376009473 dimerization interface [polypeptide binding]; other site 762376009474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376009475 DNA binding site [nucleotide binding] 762376009476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376009477 dimer interface [polypeptide binding]; other site 762376009478 phosphorylation site [posttranslational modification] 762376009479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009480 ATP binding site [chemical binding]; other site 762376009481 Mg2+ binding site [ion binding]; other site 762376009482 G-X-G motif; other site 762376009483 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 762376009484 CGNR zinc finger; Region: zf-CGNR; pfam11706 762376009485 Epoxide hydrolase N terminus; Region: EHN; pfam06441 762376009486 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 762376009487 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376009488 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 762376009489 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009490 N-terminal plug; other site 762376009491 ligand-binding site [chemical binding]; other site 762376009492 fec operon regulator FecR; Reviewed; Region: PRK09774 762376009493 FecR protein; Region: FecR; pfam04773 762376009494 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376009495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376009496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376009497 DNA binding residues [nucleotide binding] 762376009498 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376009499 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376009500 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376009501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009502 putative substrate translocation pore; other site 762376009503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009504 DNA-binding site [nucleotide binding]; DNA binding site 762376009505 FCD domain; Region: FCD; cl11656 762376009506 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376009507 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376009508 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376009509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376009510 substrate binding site [chemical binding]; other site 762376009511 oxyanion hole (OAH) forming residues; other site 762376009512 trimer interface [polypeptide binding]; other site 762376009513 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376009514 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376009515 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 762376009516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009517 N-terminal plug; other site 762376009518 ligand-binding site [chemical binding]; other site 762376009519 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 762376009520 PemK-like protein; Region: PemK; cl00995 762376009521 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 762376009522 C-terminal domain interface [polypeptide binding]; other site 762376009523 GSH binding site (G-site) [chemical binding]; other site 762376009524 dimer interface [polypeptide binding]; other site 762376009525 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 762376009526 N-terminal domain interface [polypeptide binding]; other site 762376009527 dimer interface [polypeptide binding]; other site 762376009528 substrate binding pocket (H-site) [chemical binding]; other site 762376009529 YceI-like domain; Region: YceI; cl01001 762376009530 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762376009531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376009532 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376009533 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376009534 active site 762376009535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009536 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376009537 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376009538 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376009539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376009543 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376009544 tetramerization interface [polypeptide binding]; other site 762376009545 NAD(P) binding site [chemical binding]; other site 762376009546 catalytic residues [active] 762376009547 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009548 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376009549 putative ligand binding site [chemical binding]; other site 762376009550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376009551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376009552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009554 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376009555 putative dimerization interface [polypeptide binding]; other site 762376009556 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376009557 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376009558 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376009559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376009560 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 762376009561 dimer interface [polypeptide binding]; other site 762376009562 catalytic triad [active] 762376009563 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376009564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376009565 RNA binding surface [nucleotide binding]; other site 762376009566 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 762376009567 active site 762376009568 Domain of unknown function DUF20; Region: UPF0118; cl00465 762376009569 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762376009570 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376009571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376009572 substrate binding pocket [chemical binding]; other site 762376009573 membrane-bound complex binding site; other site 762376009574 hinge residues; other site 762376009575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376009576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376009577 catalytic residue [active] 762376009578 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376009579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009580 D-galactonate transporter; Region: 2A0114; TIGR00893 762376009581 putative substrate translocation pore; other site 762376009582 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376009583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009585 dimerization interface [polypeptide binding]; other site 762376009586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376009587 Phage integrase family; Region: Phage_integrase; pfam00589 762376009588 DNA binding site [nucleotide binding] 762376009589 Int/Topo IB signature motif; other site 762376009590 active site 762376009591 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376009592 metal binding site [ion binding]; metal-binding site 762376009593 active site 762376009594 I-site; other site 762376009595 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 762376009596 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376009597 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376009598 Rdx family; Region: Rdx; cl01407 762376009599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009600 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 762376009601 putative substrate translocation pore; other site 762376009602 enoyl-CoA hydratase; Validated; Region: PRK08139 762376009603 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376009604 substrate binding site [chemical binding]; other site 762376009605 oxyanion hole (OAH) forming residues; other site 762376009606 trimer interface [polypeptide binding]; other site 762376009607 Chromate transporter; Region: Chromate_transp; pfam02417 762376009608 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 762376009609 Chromate transporter; Region: Chromate_transp; pfam02417 762376009610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 762376009611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009612 ATP binding site [chemical binding]; other site 762376009613 Mg2+ binding site [ion binding]; other site 762376009614 G-X-G motif; other site 762376009615 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376009616 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376009617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009618 DNA-binding site [nucleotide binding]; DNA binding site 762376009619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376009620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009621 homodimer interface [polypeptide binding]; other site 762376009622 catalytic residue [active] 762376009623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376009624 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376009625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376009626 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376009627 Sulfatase; Region: Sulfatase; cl10460 762376009628 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 762376009629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376009630 hypothetical protein; Provisional; Region: PRK13685 762376009631 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762376009632 metal ion-dependent adhesion site (MIDAS); other site 762376009633 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 762376009634 metal ion-dependent adhesion site (MIDAS); other site 762376009635 Protein of unknown function DUF58; Region: DUF58; pfam01882 762376009636 MoxR-like ATPases [General function prediction only]; Region: COG0714 762376009637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376009638 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376009639 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 762376009640 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 762376009641 Integral membrane protein TerC family; Region: TerC; cl10468 762376009642 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376009643 Transporter associated domain; Region: CorC_HlyC; pfam03471 762376009644 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 762376009645 MgtC family; Region: MgtC; cl12207 762376009646 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376009647 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376009648 Walker A/P-loop; other site 762376009649 ATP binding site [chemical binding]; other site 762376009650 Q-loop/lid; other site 762376009651 ABC transporter signature motif; other site 762376009652 Walker B; other site 762376009653 D-loop; other site 762376009654 H-loop/switch region; other site 762376009655 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376009656 Walker A/P-loop; other site 762376009657 ATP binding site [chemical binding]; other site 762376009658 Q-loop/lid; other site 762376009659 ABC transporter signature motif; other site 762376009660 Walker B; other site 762376009661 D-loop; other site 762376009662 H-loop/switch region; other site 762376009663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376009664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762376009665 putative catalytic site [active] 762376009666 putative metal binding site [ion binding]; other site 762376009667 putative phosphate binding site [ion binding]; other site 762376009668 cardiolipin synthase 2; Provisional; Region: PRK11263 762376009669 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376009670 putative active site [active] 762376009671 catalytic site [active] 762376009672 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376009673 putative active site [active] 762376009674 catalytic site [active] 762376009675 Predicted integral membrane protein [Function unknown]; Region: COG0392 762376009676 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 762376009677 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376009678 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 762376009679 thiamine pyrophosphate protein; Provisional; Region: PRK08273 762376009680 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 762376009681 PYR/PP interface [polypeptide binding]; other site 762376009682 tetramer interface [polypeptide binding]; other site 762376009683 dimer interface [polypeptide binding]; other site 762376009684 TPP binding site [chemical binding]; other site 762376009685 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376009686 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 762376009687 TPP-binding site [chemical binding]; other site 762376009688 glycogen synthase; Provisional; Region: glgA; PRK00654 762376009689 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 762376009690 ADP-binding pocket [chemical binding]; other site 762376009691 homodimer interface [polypeptide binding]; other site 762376009692 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 762376009693 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009694 trehalose synthase; Region: treS_nterm; TIGR02456 762376009695 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009696 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 762376009697 glycogen branching enzyme; Provisional; Region: PRK05402 762376009698 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 762376009699 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009700 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 762376009701 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 762376009702 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 762376009703 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009704 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 762376009705 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 762376009706 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009707 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762376009708 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 762376009709 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 762376009710 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 762376009711 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762376009712 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376009713 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 762376009714 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 762376009715 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376009716 Ligand Binding Site [chemical binding]; other site 762376009717 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376009718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009719 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 762376009720 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659 762376009721 DNA binding site [nucleotide binding] 762376009722 active site 762376009723 Int/Topo IB signature motif; other site 762376009724 catalytic residues [active] 762376009725 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 762376009726 dimerization interface [polypeptide binding]; other site 762376009727 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 762376009728 short chain dehydrogenase; Provisional; Region: PRK06701 762376009729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009730 NAD(P) binding site [chemical binding]; other site 762376009731 active site 762376009732 Predicted outer membrane protein [Function unknown]; Region: COG3652 762376009733 Domain of unknown function (DUF378); Region: DUF378; cl00943 762376009734 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009736 active site 762376009737 phosphorylation site [posttranslational modification] 762376009738 intermolecular recognition site; other site 762376009739 dimerization interface [polypeptide binding]; other site 762376009740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376009741 Walker A motif; other site 762376009742 ATP binding site [chemical binding]; other site 762376009743 Walker B motif; other site 762376009744 arginine finger; other site 762376009745 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376009746 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762376009747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376009748 Walker A motif; other site 762376009749 ATP binding site [chemical binding]; other site 762376009750 Walker B motif; other site 762376009751 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376009752 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 762376009753 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 762376009754 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 762376009755 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 762376009756 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762376009757 PAS domain S-box; Region: sensory_box; TIGR00229 762376009758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376009759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376009760 putative active site [active] 762376009761 heme pocket [chemical binding]; other site 762376009762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376009763 dimer interface [polypeptide binding]; other site 762376009764 phosphorylation site [posttranslational modification] 762376009765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009766 ATP binding site [chemical binding]; other site 762376009767 Mg2+ binding site [ion binding]; other site 762376009768 G-X-G motif; other site 762376009769 Response regulator receiver domain; Region: Response_reg; pfam00072 762376009770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009771 active site 762376009772 phosphorylation site [posttranslational modification] 762376009773 intermolecular recognition site; other site 762376009774 dimerization interface [polypeptide binding]; other site 762376009775 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 762376009776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009777 putative substrate translocation pore; other site 762376009778 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376009779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009780 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376009781 putative dimerization interface [polypeptide binding]; other site 762376009782 putative substrate binding pocket [chemical binding]; other site 762376009783 conserved hypothetical protein; Region: TIGR02231 762376009784 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 762376009785 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 762376009786 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 762376009787 FAD binding pocket [chemical binding]; other site 762376009788 FAD binding motif [chemical binding]; other site 762376009789 phosphate binding motif [ion binding]; other site 762376009790 beta-alpha-beta structure motif; other site 762376009791 NAD binding pocket [chemical binding]; other site 762376009792 Response regulator receiver domain; Region: Response_reg; pfam00072 762376009793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009794 active site 762376009795 phosphorylation site [posttranslational modification] 762376009796 intermolecular recognition site; other site 762376009797 dimerization interface [polypeptide binding]; other site 762376009798 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376009799 NeuB family; Region: NeuB; cl00496 762376009800 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376009801 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376009802 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376009803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376009804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376009805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009806 active site 762376009807 phosphorylation site [posttranslational modification] 762376009808 intermolecular recognition site; other site 762376009809 dimerization interface [polypeptide binding]; other site 762376009810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376009811 DNA binding site [nucleotide binding] 762376009812 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376009813 Beta-lactamase; Region: Beta-lactamase; cl01009 762376009814 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 762376009815 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762376009816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376009817 Walker A/P-loop; other site 762376009818 ATP binding site [chemical binding]; other site 762376009819 Q-loop/lid; other site 762376009820 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376009821 ABC transporter signature motif; other site 762376009822 Walker B; other site 762376009823 ABC transporter; Region: ABC_tran_2; pfam12848 762376009824 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376009825 Sulfatase; Region: Sulfatase; cl10460 762376009826 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376009827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009829 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376009830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009832 dimerization interface [polypeptide binding]; other site 762376009833 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009835 Cytochrome P450; Region: p450; cl12078 762376009836 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376009837 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 762376009838 FMN-binding pocket [chemical binding]; other site 762376009839 flavin binding motif; other site 762376009840 phosphate binding motif [ion binding]; other site 762376009841 beta-alpha-beta structure motif; other site 762376009842 NAD binding pocket [chemical binding]; other site 762376009843 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376009844 catalytic loop [active] 762376009845 iron binding site [ion binding]; other site 762376009846 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 762376009847 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376009848 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 762376009849 phosphate binding site [ion binding]; other site 762376009850 Predicted acetyltransferase [General function prediction only]; Region: COG3393 762376009851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376009852 Coenzyme A binding pocket [chemical binding]; other site 762376009853 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 762376009854 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376009855 putative active site [active] 762376009856 putative metal binding site [ion binding]; other site 762376009857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376009860 PAS domain S-box; Region: sensory_box; TIGR00229 762376009861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376009862 putative active site [active] 762376009863 heme pocket [chemical binding]; other site 762376009864 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376009865 metal binding site [ion binding]; metal-binding site 762376009866 active site 762376009867 I-site; other site 762376009868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009869 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 762376009870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376009871 inhibitor-cofactor binding pocket; inhibition site 762376009872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009873 catalytic residue [active] 762376009874 Arginase family; Region: Arginase; cl00306 762376009875 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009876 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376009877 putative ligand binding site [chemical binding]; other site 762376009878 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 762376009879 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376009880 putative NAD(P) binding site [chemical binding]; other site 762376009881 catalytic Zn binding site [ion binding]; other site 762376009882 RES domain; Region: RES; cl02411 762376009883 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 762376009884 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 762376009885 Protein of unknown function (DUF423); Region: DUF423; cl01008 762376009886 EamA-like transporter family; Region: EamA; cl01037 762376009887 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376009888 EamA-like transporter family; Region: EamA; cl01037 762376009889 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376009890 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376009891 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 762376009892 dimer interface [polypeptide binding]; other site 762376009893 N-terminal domain interface [polypeptide binding]; other site 762376009894 substrate binding pocket (H-site) [chemical binding]; other site 762376009895 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 762376009896 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 762376009897 glutathionine S-transferase; Provisional; Region: PRK10542 762376009898 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 762376009899 C-terminal domain interface [polypeptide binding]; other site 762376009900 GSH binding site (G-site) [chemical binding]; other site 762376009901 dimer interface [polypeptide binding]; other site 762376009902 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 762376009903 dimer interface [polypeptide binding]; other site 762376009904 N-terminal domain interface [polypeptide binding]; other site 762376009905 substrate binding pocket (H-site) [chemical binding]; other site 762376009906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009909 dimerization interface [polypeptide binding]; other site 762376009910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009912 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376009913 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376009914 active site 762376009915 putative substrate binding pocket [chemical binding]; other site 762376009916 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376009917 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 762376009918 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376009919 Walker A/P-loop; other site 762376009920 ATP binding site [chemical binding]; other site 762376009921 Q-loop/lid; other site 762376009922 ABC transporter signature motif; other site 762376009923 Walker B; other site 762376009924 D-loop; other site 762376009925 H-loop/switch region; other site 762376009926 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 762376009927 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376009928 Walker A/P-loop; other site 762376009929 ATP binding site [chemical binding]; other site 762376009930 Q-loop/lid; other site 762376009931 ABC transporter signature motif; other site 762376009932 Walker B; other site 762376009933 D-loop; other site 762376009934 H-loop/switch region; other site 762376009935 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 762376009936 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 762376009937 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376009938 TM-ABC transporter signature motif; other site 762376009939 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376009940 TM-ABC transporter signature motif; other site 762376009941 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009942 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376009943 dimerization interface [polypeptide binding]; other site 762376009944 ligand binding site [chemical binding]; other site 762376009945 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 762376009946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009948 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376009949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376009950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762376009951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376009952 dimer interface [polypeptide binding]; other site 762376009953 conserved gate region; other site 762376009954 putative PBP binding loops; other site 762376009955 ABC-ATPase subunit interface; other site 762376009956 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762376009957 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 762376009958 Walker A/P-loop; other site 762376009959 ATP binding site [chemical binding]; other site 762376009960 Q-loop/lid; other site 762376009961 ABC transporter signature motif; other site 762376009962 Walker B; other site 762376009963 D-loop; other site 762376009964 H-loop/switch region; other site 762376009965 TOBE domain; Region: TOBE_2; cl01440 762376009966 MltA-interacting protein MipA; Region: MipA; cl01504 762376009967 Beta-lactamase; Region: Beta-lactamase; cl01009 762376009968 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376009969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376009970 dimer interface [polypeptide binding]; other site 762376009971 phosphorylation site [posttranslational modification] 762376009972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009973 ATP binding site [chemical binding]; other site 762376009974 Mg2+ binding site [ion binding]; other site 762376009975 G-X-G motif; other site 762376009976 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 762376009977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376009978 active site 762376009979 phosphorylation site [posttranslational modification] 762376009980 intermolecular recognition site; other site 762376009981 dimerization interface [polypeptide binding]; other site 762376009982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376009983 DNA binding site [nucleotide binding] 762376009984 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009985 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376009986 dimerization interface [polypeptide binding]; other site 762376009987 ligand binding site [chemical binding]; other site 762376009988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376009989 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376009990 Ferritin-like domain; Region: Ferritin; pfam00210 762376009991 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762376009992 dimerization interface [polypeptide binding]; other site 762376009993 DPS ferroxidase diiron center [ion binding]; other site 762376009994 ion pore; other site 762376009995 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 762376009996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376009997 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 762376009998 dimerization interface [polypeptide binding]; other site 762376009999 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762376010000 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 762376010001 generic binding surface II; other site 762376010002 ssDNA binding site; other site 762376010003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376010004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376010005 ATP binding site [chemical binding]; other site 762376010006 putative Mg++ binding site [ion binding]; other site 762376010007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376010008 nucleotide binding region [chemical binding]; other site 762376010009 ATP-binding site [chemical binding]; other site 762376010010 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376010011 homotrimer interaction site [polypeptide binding]; other site 762376010012 putative active site [active] 762376010013 Fic/DOC family; Region: Fic; cl00960 762376010014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010016 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376010017 putative dimerization interface [polypeptide binding]; other site 762376010018 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376010019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010021 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376010022 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 762376010023 FAD binding pocket [chemical binding]; other site 762376010024 FAD binding motif [chemical binding]; other site 762376010025 phosphate binding motif [ion binding]; other site 762376010026 beta-alpha-beta structure motif; other site 762376010027 NAD binding pocket [chemical binding]; other site 762376010028 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 762376010029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010031 dimer interface [polypeptide binding]; other site 762376010032 conserved gate region; other site 762376010033 putative PBP binding loops; other site 762376010034 ABC-ATPase subunit interface; other site 762376010035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010036 dimer interface [polypeptide binding]; other site 762376010037 conserved gate region; other site 762376010038 putative PBP binding loops; other site 762376010039 ABC-ATPase subunit interface; other site 762376010040 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 762376010041 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 762376010042 Walker A/P-loop; other site 762376010043 ATP binding site [chemical binding]; other site 762376010044 Q-loop/lid; other site 762376010045 ABC transporter signature motif; other site 762376010046 Walker B; other site 762376010047 D-loop; other site 762376010048 H-loop/switch region; other site 762376010049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010051 Pirin-related protein [General function prediction only]; Region: COG1741 762376010052 Cupin domain; Region: Cupin_2; cl09118 762376010053 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 762376010054 Cupin domain; Region: Cupin_2; cl09118 762376010055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010056 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 762376010057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010058 dimerization interface [polypeptide binding]; other site 762376010059 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 762376010060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376010061 active site 762376010062 phosphorylation site [posttranslational modification] 762376010063 intermolecular recognition site; other site 762376010064 dimerization interface [polypeptide binding]; other site 762376010065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376010066 Walker A motif; other site 762376010067 ATP binding site [chemical binding]; other site 762376010068 Walker B motif; other site 762376010069 arginine finger; other site 762376010070 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376010071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762376010072 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 762376010073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 762376010074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010075 ATP binding site [chemical binding]; other site 762376010076 Mg2+ binding site [ion binding]; other site 762376010077 G-X-G motif; other site 762376010078 glutamine synthetase; Provisional; Region: glnA; PRK09469 762376010079 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762376010080 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762376010081 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 762376010082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376010083 FeS/SAM binding site; other site 762376010084 HemN C-terminal region; Region: HemN_C; pfam06969 762376010085 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 762376010086 active site 762376010087 dimerization interface [polypeptide binding]; other site 762376010088 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376010089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain...; Region: CBS_pair_GGDEF_assoc; cd04598 762376010090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376010091 metal binding site [ion binding]; metal-binding site 762376010092 active site 762376010093 I-site; other site 762376010094 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376010095 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376010096 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376010097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010098 active site 762376010099 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376010100 ribonuclease PH; Reviewed; Region: rph; PRK00173 762376010101 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 762376010102 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 762376010103 hypothetical protein; Provisional; Region: PRK11820 762376010104 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 762376010105 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 762376010106 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 762376010107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376010108 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762376010109 Amino acid permease; Region: AA_permease; pfam00324 762376010110 AMP nucleosidase; Provisional; Region: PRK08292 762376010111 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 762376010112 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 762376010113 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762376010114 NlpC/P60 family; Region: NLPC_P60; cl11438 762376010115 classical (c) SDRs; Region: SDR_c; cd05233 762376010116 NAD(P) binding site [chemical binding]; other site 762376010117 active site 762376010118 Cytochrome c; Region: Cytochrom_C; cl11414 762376010119 Cytochrome c; Region: Cytochrom_C; cl11414 762376010120 Cytochrome c [Energy production and conversion]; Region: COG3258 762376010121 Cytochrome c; Region: Cytochrom_C; cl11414 762376010122 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 762376010123 catalytic site [active] 762376010124 G-X2-G-X-G-K; other site 762376010125 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 762376010126 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762376010127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376010128 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762376010129 synthetase active site [active] 762376010130 NTP binding site [chemical binding]; other site 762376010131 metal binding site [ion binding]; metal-binding site 762376010132 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 762376010133 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762376010134 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 762376010135 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376010136 Walker A/P-loop; other site 762376010137 ATP binding site [chemical binding]; other site 762376010138 Q-loop/lid; other site 762376010139 ABC transporter signature motif; other site 762376010140 Walker B; other site 762376010141 D-loop; other site 762376010142 H-loop/switch region; other site 762376010143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010144 dimer interface [polypeptide binding]; other site 762376010145 conserved gate region; other site 762376010146 putative PBP binding loops; other site 762376010147 ABC-ATPase subunit interface; other site 762376010148 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 762376010149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376010150 substrate binding pocket [chemical binding]; other site 762376010151 membrane-bound complex binding site; other site 762376010152 hinge residues; other site 762376010153 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376010154 5-oxoprolinase; Region: PLN02666 762376010155 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376010156 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 762376010157 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 762376010158 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 762376010159 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 762376010160 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 762376010161 putative NADH binding site [chemical binding]; other site 762376010162 putative active site [active] 762376010163 nudix motif; other site 762376010164 putative metal binding site [ion binding]; other site 762376010165 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376010166 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376010167 DctM-like transporters; Region: DctM; pfam06808 762376010168 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376010169 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376010170 trimer interface [polypeptide binding]; other site 762376010171 eyelet of channel; other site 762376010172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376010173 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376010174 Walker A/P-loop; other site 762376010175 ATP binding site [chemical binding]; other site 762376010176 Q-loop/lid; other site 762376010177 ABC transporter signature motif; other site 762376010178 Walker B; other site 762376010179 D-loop; other site 762376010180 H-loop/switch region; other site 762376010181 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376010182 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376010183 Walker A/P-loop; other site 762376010184 ATP binding site [chemical binding]; other site 762376010185 Q-loop/lid; other site 762376010186 ABC transporter signature motif; other site 762376010187 Walker B; other site 762376010188 D-loop; other site 762376010189 H-loop/switch region; other site 762376010190 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376010191 TM-ABC transporter signature motif; other site 762376010192 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376010193 TM-ABC transporter signature motif; other site 762376010194 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376010195 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 762376010196 putative ligand binding site [chemical binding]; other site 762376010197 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 762376010198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010199 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376010200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376010201 dimerization interface [polypeptide binding]; other site 762376010202 amidase; Provisional; Region: PRK07056 762376010203 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376010204 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 762376010205 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376010206 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376010207 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376010208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376010211 dimerization interface [polypeptide binding]; other site 762376010212 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 762376010213 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 762376010214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010215 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 762376010216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376010217 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 762376010218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376010219 motif II; other site 762376010220 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376010221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010222 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376010223 dimerization interface [polypeptide binding]; other site 762376010224 substrate binding pocket [chemical binding]; other site 762376010225 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376010226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376010227 Walker A/P-loop; other site 762376010228 ATP binding site [chemical binding]; other site 762376010229 Q-loop/lid; other site 762376010230 ABC transporter signature motif; other site 762376010231 Walker B; other site 762376010232 D-loop; other site 762376010233 H-loop/switch region; other site 762376010234 TOBE domain; Region: TOBE_2; cl01440 762376010235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376010236 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376010237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010238 dimer interface [polypeptide binding]; other site 762376010239 conserved gate region; other site 762376010240 putative PBP binding loops; other site 762376010241 ABC-ATPase subunit interface; other site 762376010242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010243 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 762376010244 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762376010245 Walker A/P-loop; other site 762376010246 ATP binding site [chemical binding]; other site 762376010247 Q-loop/lid; other site 762376010248 ABC transporter signature motif; other site 762376010249 Walker B; other site 762376010250 D-loop; other site 762376010251 H-loop/switch region; other site 762376010252 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 762376010253 active site 762376010254 catalytic triad [active] 762376010255 oxyanion hole [active] 762376010256 switch loop; other site 762376010257 periplasmic folding chaperone; Provisional; Region: PRK10788 762376010258 SurA N-terminal domain; Region: SurA_N; pfam09312 762376010259 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376010260 hypothetical protein; Provisional; Region: PRK07338 762376010261 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 762376010262 metal binding site [ion binding]; metal-binding site 762376010263 dimer interface [polypeptide binding]; other site 762376010264 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 762376010265 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762376010266 putative active site [active] 762376010267 catalytic site [active] 762376010268 putative metal binding site [ion binding]; other site 762376010269 Protein of unknown function (DUF519); Region: DUF519; cl04492 762376010270 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 762376010271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376010272 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376010273 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 762376010274 catalytic triad [active] 762376010275 dimer interface [polypeptide binding]; other site 762376010276 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376010277 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762376010278 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 762376010279 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 762376010280 DNA binding residues [nucleotide binding] 762376010281 dimer interface [polypeptide binding]; other site 762376010282 copper binding site [ion binding]; other site 762376010283 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 762376010284 TRAM domain; Region: TRAM; cl01282 762376010285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376010286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010287 putative substrate translocation pore; other site 762376010288 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376010289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010290 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376010291 dimerization interface [polypeptide binding]; other site 762376010292 substrate binding pocket [chemical binding]; other site 762376010293 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 762376010294 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 762376010295 active site 762376010296 catalytic site [active] 762376010297 substrate binding site [chemical binding]; other site 762376010298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 762376010299 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 762376010300 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376010301 putative peptidoglycan binding site; other site 762376010302 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376010303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376010304 Survival protein SurE; Region: SurE; cl00448 762376010305 Domain of unknown function (DUF205); Region: DUF205; cl00410 762376010306 UGMP family protein; Validated; Region: PRK09604 762376010307 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 762376010308 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376010309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 762376010310 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762376010311 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 762376010312 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376010313 catalytic residues [active] 762376010314 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762376010315 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762376010316 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762376010317 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376010318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010319 dimer interface [polypeptide binding]; other site 762376010320 conserved gate region; other site 762376010321 putative PBP binding loops; other site 762376010322 ABC-ATPase subunit interface; other site 762376010323 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376010324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010325 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376010326 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376010327 Walker A/P-loop; other site 762376010328 ATP binding site [chemical binding]; other site 762376010329 Q-loop/lid; other site 762376010330 ABC transporter signature motif; other site 762376010331 Walker B; other site 762376010332 D-loop; other site 762376010333 H-loop/switch region; other site 762376010334 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376010335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010337 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 762376010338 putative active site [active] 762376010339 putative catalytic site [active] 762376010340 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376010341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376010342 substrate binding site [chemical binding]; other site 762376010343 oxyanion hole (OAH) forming residues; other site 762376010344 trimer interface [polypeptide binding]; other site 762376010345 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376010346 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376010347 thiolase; Provisional; Region: PRK06158 762376010348 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376010349 active site 762376010350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376010351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010352 NAD(P) binding site [chemical binding]; other site 762376010353 active site 762376010354 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 762376010355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376010356 Walker A/P-loop; other site 762376010357 ATP binding site [chemical binding]; other site 762376010358 Q-loop/lid; other site 762376010359 ABC transporter signature motif; other site 762376010360 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376010361 Walker B; other site 762376010362 D-loop; other site 762376010363 H-loop/switch region; other site 762376010364 ABC transporter; Region: ABC_tran_2; pfam12848 762376010365 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376010366 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 762376010367 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376010368 NADP binding site [chemical binding]; other site 762376010369 dimer interface [polypeptide binding]; other site 762376010370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010371 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 762376010372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010373 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376010374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010375 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010376 dimerization interface [polypeptide binding]; other site 762376010377 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 762376010378 dimer interface [polypeptide binding]; other site 762376010379 catalytic triad [active] 762376010380 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762376010381 nucleoside/Zn binding site; other site 762376010382 dimer interface [polypeptide binding]; other site 762376010383 catalytic motif [active] 762376010384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376010385 motif II; other site 762376010386 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 762376010387 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 762376010388 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 762376010389 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 762376010390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 762376010391 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 762376010392 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 762376010393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 762376010394 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 762376010395 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 762376010396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010398 Protein of unknown function (DUF342); Region: DUF342; pfam03961 762376010399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010401 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376010402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376010403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376010404 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 762376010405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010406 active site 762376010407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376010408 Walker A/P-loop; other site 762376010409 ATP binding site [chemical binding]; other site 762376010410 Q-loop/lid; other site 762376010411 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762376010412 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762376010413 active site 762376010414 metal binding site [ion binding]; metal-binding site 762376010415 DNA binding site [nucleotide binding] 762376010416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376010418 active site 762376010419 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376010420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010422 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376010423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010425 dimerization interface [polypeptide binding]; other site 762376010426 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376010427 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 762376010428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010429 Protein of unknown function (DUF502); Region: DUF502; cl01107 762376010430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762376010431 Restriction endonuclease; Region: Mrr_cat; cl00747 762376010432 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 762376010433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376010434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010435 active site 762376010436 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 762376010437 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 762376010438 glucose-1-dehydrogenase; Provisional; Region: PRK08936 762376010439 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 762376010440 NAD binding site [chemical binding]; other site 762376010441 homodimer interface [polypeptide binding]; other site 762376010442 active site 762376010443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376010444 metal binding site [ion binding]; metal-binding site 762376010445 active site 762376010446 I-site; other site 762376010447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376010448 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376010449 substrate binding pocket [chemical binding]; other site 762376010450 membrane-bound complex binding site; other site 762376010451 hinge residues; other site 762376010452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376010453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010455 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376010456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010459 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376010460 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376010461 putative dimerization interface [polypeptide binding]; other site 762376010462 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376010463 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376010464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376010465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010466 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 762376010467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762376010468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010469 dimer interface [polypeptide binding]; other site 762376010470 conserved gate region; other site 762376010471 putative PBP binding loops; other site 762376010472 ABC-ATPase subunit interface; other site 762376010473 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376010474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010475 dimer interface [polypeptide binding]; other site 762376010476 putative PBP binding loops; other site 762376010477 ABC-ATPase subunit interface; other site 762376010478 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762376010479 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 762376010480 Walker A/P-loop; other site 762376010481 ATP binding site [chemical binding]; other site 762376010482 Q-loop/lid; other site 762376010483 ABC transporter signature motif; other site 762376010484 Walker B; other site 762376010485 D-loop; other site 762376010486 H-loop/switch region; other site 762376010487 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762376010488 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 762376010489 Walker A/P-loop; other site 762376010490 ATP binding site [chemical binding]; other site 762376010491 Q-loop/lid; other site 762376010492 ABC transporter signature motif; other site 762376010493 Walker B; other site 762376010494 D-loop; other site 762376010495 H-loop/switch region; other site 762376010496 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 762376010497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010498 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 762376010499 glycerol-3-phosphate dehydrogenase; Region: PLN02464 762376010500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376010501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376010502 Zn2+ binding site [ion binding]; other site 762376010503 Mg2+ binding site [ion binding]; other site 762376010504 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 762376010505 potential catalytic triad [active] 762376010506 conserved cys residue [active] 762376010507 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 762376010508 Prostaglandin dehydrogenases; Region: PGDH; cd05288 762376010509 NAD(P) binding site [chemical binding]; other site 762376010510 substrate binding site [chemical binding]; other site 762376010511 dimer interface [polypeptide binding]; other site 762376010512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376010513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376010514 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376010515 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376010516 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762376010517 Walker A/P-loop; other site 762376010518 ATP binding site [chemical binding]; other site 762376010519 Q-loop/lid; other site 762376010520 ABC transporter signature motif; other site 762376010521 Walker B; other site 762376010522 D-loop; other site 762376010523 H-loop/switch region; other site 762376010524 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762376010525 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762376010526 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376010527 NodT family; Region: outer_NodT; TIGR01845 762376010528 Outer membrane efflux protein; Region: OEP; pfam02321 762376010529 Outer membrane efflux protein; Region: OEP; pfam02321 762376010530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376010531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 762376010532 DNA binding site [nucleotide binding] 762376010533 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 762376010534 putative deacylase active site [active] 762376010535 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 762376010536 Protein of unknown function (DUF833); Region: DUF833; cl01315 762376010537 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762376010538 active site 762376010539 catalytic site [active] 762376010540 MAPEG family; Region: MAPEG; cl09190 762376010541 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 762376010542 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376010543 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 762376010544 FMN binding site [chemical binding]; other site 762376010545 active site 762376010546 substrate binding site [chemical binding]; other site 762376010547 catalytic residue [active] 762376010548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376010549 dimerization interface [polypeptide binding]; other site 762376010550 putative DNA binding site [nucleotide binding]; other site 762376010551 putative Zn2+ binding site [ion binding]; other site 762376010552 amidase; Provisional; Region: PRK07487 762376010553 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376010554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010556 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376010557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010559 dimerization interface [polypeptide binding]; other site 762376010560 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 762376010561 RF-1 domain; Region: RF-1; cl02875 762376010562 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 762376010563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376010564 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 762376010565 active site 762376010566 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376010567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010568 Fusaric acid resistance protein family; Region: FUSC; pfam04632 762376010569 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 762376010570 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 762376010571 NodT family; Region: outer_NodT; TIGR01845 762376010572 Outer membrane efflux protein; Region: OEP; pfam02321 762376010573 Outer membrane efflux protein; Region: OEP; pfam02321 762376010574 Predicted esterase [General function prediction only]; Region: COG0400 762376010575 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376010576 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762376010577 Amino acid permease; Region: AA_permease; pfam00324 762376010578 Cell division inhibitor SulA; Region: SulA; cl01880 762376010579 DNA Polymerase Y-family; Region: PolY_like; cd03468 762376010580 active site 762376010581 DNA binding site [nucleotide binding] 762376010582 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 762376010583 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 762376010584 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 762376010585 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 762376010586 generic binding surface II; other site 762376010587 generic binding surface I; other site 762376010588 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 762376010589 active site 762376010590 catalytic triad [active] 762376010591 oxyanion hole [active] 762376010592 transcriptional regulator; Provisional; Region: PRK10632 762376010593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376010595 putative effector binding pocket; other site 762376010596 dimerization interface [polypeptide binding]; other site 762376010597 peptidase; Reviewed; Region: PRK13004 762376010598 M28, and M42; Region: Zinc_peptidase_like; cl14876 762376010599 metal binding site [ion binding]; metal-binding site 762376010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010601 D-galactonate transporter; Region: 2A0114; TIGR00893 762376010602 putative substrate translocation pore; other site 762376010603 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 762376010604 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376010605 tetramer interface [polypeptide binding]; other site 762376010606 active site 762376010607 catalytic triad [active] 762376010608 dimer interface [polypeptide binding]; other site 762376010609 allantoate amidohydrolase; Reviewed; Region: PRK12893 762376010610 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376010611 active site 762376010612 metal binding site [ion binding]; metal-binding site 762376010613 dimer interface [polypeptide binding]; other site 762376010614 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 762376010615 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cd00640 762376010616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376010617 catalytic residue [active] 762376010618 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376010619 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376010620 putative active site [active] 762376010621 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 762376010622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376010625 dimerization interface [polypeptide binding]; other site 762376010626 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376010627 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376010628 Walker A/P-loop; other site 762376010629 ATP binding site [chemical binding]; other site 762376010630 Q-loop/lid; other site 762376010631 ABC transporter signature motif; other site 762376010632 Walker B; other site 762376010633 D-loop; other site 762376010634 H-loop/switch region; other site 762376010635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010636 dimer interface [polypeptide binding]; other site 762376010637 conserved gate region; other site 762376010638 putative PBP binding loops; other site 762376010639 ABC-ATPase subunit interface; other site 762376010640 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376010641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010642 dimer interface [polypeptide binding]; other site 762376010643 conserved gate region; other site 762376010644 putative PBP binding loops; other site 762376010645 ABC-ATPase subunit interface; other site 762376010646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376010647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376010648 substrate binding pocket [chemical binding]; other site 762376010649 membrane-bound complex binding site; other site 762376010650 hinge residues; other site 762376010651 aspartate aminotransferase; Provisional; Region: PRK08361 762376010652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376010653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376010654 homodimer interface [polypeptide binding]; other site 762376010655 catalytic residue [active] 762376010656 hypothetical protein; Validated; Region: PRK06201 762376010657 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 762376010658 Cupin domain; Region: Cupin_2; cl09118 762376010659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376010660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376010661 Cytochrome P450; Region: p450; cl12078 762376010662 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 762376010663 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 762376010664 FMN-binding pocket [chemical binding]; other site 762376010665 flavin binding motif; other site 762376010666 phosphate binding motif [ion binding]; other site 762376010667 beta-alpha-beta structure motif; other site 762376010668 NAD binding pocket [chemical binding]; other site 762376010669 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376010670 catalytic loop [active] 762376010671 iron binding site [ion binding]; other site 762376010672 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376010673 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376010674 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 762376010675 putative transposase OrfB; Reviewed; Region: PHA02517 762376010676 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376010677 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762376010678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376010679 active site 762376010680 HIGH motif; other site 762376010681 nucleotide binding site [chemical binding]; other site 762376010682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376010683 active site 762376010684 KMSKS motif; other site 762376010685 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762376010686 tRNA binding surface [nucleotide binding]; other site 762376010687 anticodon binding site; other site 762376010688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376010689 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 762376010690 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 762376010691 Cytochrome c; Region: Cytochrom_C; cl11414 762376010692 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376010693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010694 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 762376010695 putative effector binding pocket; other site 762376010696 putative dimerization interface [polypeptide binding]; other site 762376010697 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 762376010698 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 762376010699 putative NAD(P) binding site [chemical binding]; other site 762376010700 Found in ATP-dependent protease La (LON); Region: LON; cl01056 762376010701 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 762376010702 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376010703 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 762376010704 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762376010705 dimer interface [polypeptide binding]; other site 762376010706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010707 putative substrate translocation pore; other site 762376010708 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376010709 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376010710 metal binding site [ion binding]; metal-binding site 762376010711 putative dimer interface [polypeptide binding]; other site 762376010712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010714 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376010715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010716 DNA-binding site [nucleotide binding]; DNA binding site 762376010717 FCD domain; Region: FCD; cl11656 762376010718 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376010719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010720 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376010721 choline dehydrogenase; Validated; Region: PRK02106 762376010722 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376010723 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376010724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010725 putative substrate translocation pore; other site 762376010726 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376010727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376010728 active site 762376010729 catalytic tetrad [active] 762376010730 Beta-lactamase; Region: Beta-lactamase; cl01009 762376010731 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 762376010732 homodimer interface [polypeptide binding]; other site 762376010733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376010734 catalytic residue [active] 762376010735 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376010736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010737 DNA-binding site [nucleotide binding]; DNA binding site 762376010738 FCD domain; Region: FCD; cl11656 762376010739 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 762376010740 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376010741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376010742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010743 dimer interface [polypeptide binding]; other site 762376010744 conserved gate region; other site 762376010745 putative PBP binding loops; other site 762376010746 ABC-ATPase subunit interface; other site 762376010747 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376010748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376010749 dimer interface [polypeptide binding]; other site 762376010750 conserved gate region; other site 762376010751 putative PBP binding loops; other site 762376010752 ABC-ATPase subunit interface; other site 762376010753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376010754 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376010755 Walker A/P-loop; other site 762376010756 ATP binding site [chemical binding]; other site 762376010757 Q-loop/lid; other site 762376010758 ABC transporter signature motif; other site 762376010759 Walker B; other site 762376010760 D-loop; other site 762376010761 H-loop/switch region; other site 762376010762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376010763 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376010764 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376010765 Walker A/P-loop; other site 762376010766 ATP binding site [chemical binding]; other site 762376010767 Q-loop/lid; other site 762376010768 ABC transporter signature motif; other site 762376010769 Walker B; other site 762376010770 D-loop; other site 762376010771 H-loop/switch region; other site 762376010772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376010773 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 762376010774 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 762376010775 metal binding site [ion binding]; metal-binding site 762376010776 putative dimer interface [polypeptide binding]; other site 762376010777 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376010778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010779 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376010780 putative effector binding pocket; other site 762376010781 dimerization interface [polypeptide binding]; other site 762376010782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 762376010783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376010784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376010785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010787 Protein of unknown function (DUF523); Region: DUF523; cl00733 762376010788 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376010789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376010790 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 762376010791 putative metal binding site [ion binding]; other site 762376010792 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 762376010793 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376010794 flagellar motor protein MotA; Validated; Region: PRK08124 762376010795 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376010796 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376010797 ligand binding site [chemical binding]; other site 762376010798 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376010799 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376010800 ligand binding site [chemical binding]; other site 762376010801 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376010802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376010803 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376010804 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 762376010805 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376010806 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376010807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010808 LysE type translocator; Region: LysE; cl00565 762376010809 Flavin Reductases; Region: FlaRed; cl00801 762376010810 high affinity sulphate transporter 1; Region: sulP; TIGR00815 762376010811 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376010812 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376010813 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376010814 YCII-related domain; Region: YCII; cl00999 762376010815 YCII-related domain; Region: YCII; cl00999 762376010816 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 762376010817 putative hydrophobic ligand binding site [chemical binding]; other site 762376010818 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 762376010819 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 762376010820 Cupin domain; Region: Cupin_2; cl09118 762376010821 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376010822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376010823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376010824 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376010825 EamA-like transporter family; Region: EamA; cl01037 762376010826 EamA-like transporter family; Region: EamA; cl01037 762376010827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010828 putative substrate translocation pore; other site 762376010829 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 762376010830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010833 dimerization interface [polypeptide binding]; other site 762376010834 Uncharacterised ArCR, COG2043; Region: DUF169; cl00894 762376010835 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376010836 classical (c) SDRs; Region: SDR_c; cd05233 762376010837 NAD(P) binding site [chemical binding]; other site 762376010838 active site 762376010839 A new structural DNA glycosylase; Region: AlkD_like; cl11434 762376010840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010841 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376010842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376010843 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 762376010844 dimer interface [polypeptide binding]; other site 762376010845 ligand binding site [chemical binding]; other site 762376010846 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376010847 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376010848 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376010849 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376010850 tetracycline repressor protein TetR; Provisional; Region: PRK13756 762376010851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376010852 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 762376010853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010854 putative substrate translocation pore; other site 762376010855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 762376010856 DNA binding site [nucleotide binding] 762376010857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376010858 dimer interface [polypeptide binding]; other site 762376010859 phosphorylation site [posttranslational modification] 762376010860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010861 ATP binding site [chemical binding]; other site 762376010862 Mg2+ binding site [ion binding]; other site 762376010863 G-X-G motif; other site 762376010864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376010865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376010866 active site 762376010867 phosphorylation site [posttranslational modification] 762376010868 intermolecular recognition site; other site 762376010869 dimerization interface [polypeptide binding]; other site 762376010870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376010871 DNA binding site [nucleotide binding] 762376010872 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 762376010873 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376010874 active sites [active] 762376010875 tetramer interface [polypeptide binding]; other site 762376010876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010879 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 762376010880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010881 transcriptional regulator; Provisional; Region: PRK10632 762376010882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010883 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376010884 putative effector binding pocket; other site 762376010885 dimerization interface [polypeptide binding]; other site 762376010886 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 762376010887 Domain of unknown function (DUF802); Region: DUF802; pfam05650 762376010888 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376010889 Domain of unknown function (DUF802); Region: DUF802; pfam05650 762376010890 hypothetical protein; Provisional; Region: PRK09040 762376010891 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376010892 ligand binding site [chemical binding]; other site 762376010893 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 762376010894 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 762376010895 methionine aminopeptidase; Reviewed; Region: PRK07281 762376010896 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762376010897 active site 762376010898 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 762376010899 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 762376010900 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376010901 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376010902 putative C-terminal domain interface [polypeptide binding]; other site 762376010903 putative GSH binding site (G-site) [chemical binding]; other site 762376010904 putative dimer interface [polypeptide binding]; other site 762376010905 GST_C family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_2; cd03180 762376010906 putative N-terminal domain interface [polypeptide binding]; other site 762376010907 putative dimer interface [polypeptide binding]; other site 762376010908 putative substrate binding pocket (H-site) [chemical binding]; other site 762376010909 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 762376010910 E-class dimer interface [polypeptide binding]; other site 762376010911 P-class dimer interface [polypeptide binding]; other site 762376010912 active site 762376010913 Cu2+ binding site [ion binding]; other site 762376010914 Zn2+ binding site [ion binding]; other site 762376010915 Protein of unknown function (DUF445); Region: DUF445; pfam04286 762376010916 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376010917 gluconate transporter; Region: gntP; TIGR00791 762376010918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010920 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376010921 putative effector binding pocket; other site 762376010922 dimerization interface [polypeptide binding]; other site 762376010923 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376010924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376010925 substrate binding site [chemical binding]; other site 762376010926 oxyanion hole (OAH) forming residues; other site 762376010927 trimer interface [polypeptide binding]; other site 762376010928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010929 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376010930 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376010931 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 762376010932 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376010933 dimer interface [polypeptide binding]; other site 762376010934 active site 762376010935 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376010936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010937 active site 762376010938 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376010939 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376010940 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376010941 active site 762376010942 AMP-binding domain protein; Validated; Region: PRK07529 762376010943 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376010944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376010947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762376010949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376010950 Walker A/P-loop; other site 762376010951 ATP binding site [chemical binding]; other site 762376010952 Q-loop/lid; other site 762376010953 ABC transporter signature motif; other site 762376010954 Walker B; other site 762376010955 D-loop; other site 762376010956 H-loop/switch region; other site 762376010957 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376010958 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376010959 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376010960 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376010961 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376010962 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376010963 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376010964 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376010965 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43...; Region: PL2_Passenger_AT; cd01344 762376010966 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376010967 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376010968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010969 NAD(P) binding site [chemical binding]; other site 762376010970 active site 762376010971 transcriptional regulator; Provisional; Region: PRK10632 762376010972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010973 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 762376010974 putative effector binding pocket; other site 762376010975 putative dimerization interface [polypeptide binding]; other site 762376010976 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376010977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376010978 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376010979 dimerization interface [polypeptide binding]; other site 762376010980 substrate binding pocket [chemical binding]; other site 762376010981 Cupin domain; Region: Cupin_2; cl09118 762376010982 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 762376010983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376010984 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 762376010985 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376010986 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 762376010987 putative NAD(P) binding site [chemical binding]; other site 762376010988 putative substrate binding site [chemical binding]; other site 762376010989 catalytic Zn binding site [ion binding]; other site 762376010990 structural Zn binding site [ion binding]; other site 762376010991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010992 putative substrate translocation pore; other site 762376010993 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 762376010994 DNA binding residues [nucleotide binding] 762376010995 putative dimer interface [polypeptide binding]; other site 762376010996 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 762376010997 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 762376010998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376010999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011000 DNA-binding site [nucleotide binding]; DNA binding site 762376011001 FCD domain; Region: FCD; cl11656 762376011002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011004 dimerization interface [polypeptide binding]; other site 762376011005 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 762376011006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011007 methionine gamma-lyase; Validated; Region: PRK07049 762376011008 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376011009 homodimer interface [polypeptide binding]; other site 762376011010 substrate-cofactor binding pocket; other site 762376011011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011012 catalytic residue [active] 762376011013 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376011014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011015 Response regulator receiver domain; Region: Response_reg; pfam00072 762376011016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376011017 active site 762376011018 phosphorylation site [posttranslational modification] 762376011019 intermolecular recognition site; other site 762376011020 dimerization interface [polypeptide binding]; other site 762376011021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376011022 metal binding site [ion binding]; metal-binding site 762376011023 active site 762376011024 I-site; other site 762376011025 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 762376011026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376011027 phosphorylation site [posttranslational modification] 762376011028 intermolecular recognition site; other site 762376011029 CheB methylesterase; Region: CheB_methylest; pfam01339 762376011030 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762376011031 putative binding surface; other site 762376011032 active site 762376011033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376011034 ATP binding site [chemical binding]; other site 762376011035 Mg2+ binding site [ion binding]; other site 762376011036 G-X-G motif; other site 762376011037 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 762376011038 Response regulator receiver domain; Region: Response_reg; pfam00072 762376011039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376011040 active site 762376011041 phosphorylation site [posttranslational modification] 762376011042 intermolecular recognition site; other site 762376011043 dimerization interface [polypeptide binding]; other site 762376011044 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 762376011045 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 762376011046 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 762376011047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376011048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376011049 TPR motif; other site 762376011050 binding surface 762376011051 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 762376011052 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 762376011053 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762376011054 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376011055 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376011056 amidase; Provisional; Region: PRK07486 762376011057 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376011058 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762376011059 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 762376011060 VRR-NUC domain; Region: VRR_NUC; pfam08774 762376011061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376011062 Active site [active] 762376011063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011065 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 762376011066 putative effector binding pocket; other site 762376011067 putative dimerization interface [polypeptide binding]; other site 762376011068 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376011069 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 762376011070 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376011071 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762376011072 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376011073 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376011074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376011075 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762376011076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376011077 Walker A/P-loop; other site 762376011078 ATP binding site [chemical binding]; other site 762376011079 Q-loop/lid; other site 762376011080 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376011081 ABC transporter signature motif; other site 762376011082 Walker B; other site 762376011083 D-loop; other site 762376011084 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376011085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011088 dimerization interface [polypeptide binding]; other site 762376011089 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376011090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376011091 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376011092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011093 dimer interface [polypeptide binding]; other site 762376011094 conserved gate region; other site 762376011095 putative PBP binding loops; other site 762376011096 ABC-ATPase subunit interface; other site 762376011097 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376011098 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376011099 Walker A/P-loop; other site 762376011100 ATP binding site [chemical binding]; other site 762376011101 Q-loop/lid; other site 762376011102 ABC transporter signature motif; other site 762376011103 Walker B; other site 762376011104 D-loop; other site 762376011105 H-loop/switch region; other site 762376011106 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011107 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376011108 Walker A/P-loop; other site 762376011109 ATP binding site [chemical binding]; other site 762376011110 Q-loop/lid; other site 762376011111 ABC transporter signature motif; other site 762376011112 Walker B; other site 762376011113 D-loop; other site 762376011114 H-loop/switch region; other site 762376011115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011116 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376011117 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376011118 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376011119 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 762376011120 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 762376011121 putative active site [active] 762376011122 putative metal binding site [ion binding]; other site 762376011123 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376011124 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376011125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011127 putative effector binding pocket; other site 762376011128 dimerization interface [polypeptide binding]; other site 762376011129 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762376011130 dimer interface [polypeptide binding]; other site 762376011131 FMN binding site [chemical binding]; other site 762376011132 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376011133 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 762376011134 putative NAD(P) binding site [chemical binding]; other site 762376011135 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376011136 CoenzymeA binding site [chemical binding]; other site 762376011137 subunit interaction site [polypeptide binding]; other site 762376011138 PHB binding site; other site 762376011139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011140 putative substrate translocation pore; other site 762376011141 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 762376011142 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376011143 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 762376011144 dimer interface [polypeptide binding]; other site 762376011145 active site 762376011146 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762376011147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011148 NAD(P) binding site [chemical binding]; other site 762376011149 active site 762376011150 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376011151 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376011152 conserved cys residue [active] 762376011153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011154 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 762376011155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376011156 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376011157 active site 1 [active] 762376011158 dimer interface [polypeptide binding]; other site 762376011159 hexamer interface [polypeptide binding]; other site 762376011160 active site 2 [active] 762376011161 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376011162 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 762376011163 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376011164 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376011165 N-terminal plug; other site 762376011166 ligand-binding site [chemical binding]; other site 762376011167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376011168 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 762376011169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376011170 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376011171 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376011172 N-terminal plug; other site 762376011173 ligand-binding site [chemical binding]; other site 762376011174 fec operon regulator FecR; Reviewed; Region: PRK09774 762376011175 FecR protein; Region: FecR; pfam04773 762376011176 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376011177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376011178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376011179 DNA binding residues [nucleotide binding] 762376011180 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376011181 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 762376011182 homotrimer interaction site [polypeptide binding]; other site 762376011183 putative active site [active] 762376011184 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376011185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011187 dimerization interface [polypeptide binding]; other site 762376011188 Sulfatase; Region: Sulfatase; cl10460 762376011189 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376011190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011192 GMP synthase; Reviewed; Region: guaA; PRK00074 762376011193 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762376011194 AMP/PPi binding site [chemical binding]; other site 762376011195 candidate oxyanion hole; other site 762376011196 catalytic triad [active] 762376011197 potential glutamine specificity residues [chemical binding]; other site 762376011198 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762376011199 ATP Binding subdomain [chemical binding]; other site 762376011200 Ligand Binding sites [chemical binding]; other site 762376011201 Dimerization subdomain; other site 762376011202 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 762376011203 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 762376011204 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 762376011205 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 762376011206 active site 762376011207 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 762376011208 LysE type translocator; Region: LysE; cl00565 762376011209 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376011210 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 762376011211 conserved cys residue [active] 762376011212 Protein of unknown function, DUF393; Region: DUF393; cl01136 762376011213 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 762376011214 active site clefts [active] 762376011215 zinc binding site [ion binding]; other site 762376011216 dimer interface [polypeptide binding]; other site 762376011217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376011218 ligand binding site [chemical binding]; other site 762376011219 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 762376011220 homotrimer interaction site [polypeptide binding]; other site 762376011221 putative active site [active] 762376011222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376011225 active site 762376011226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011228 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376011229 putative dimerization interface [polypeptide binding]; other site 762376011230 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376011231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011233 dimerization interface [polypeptide binding]; other site 762376011234 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376011235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376011236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011237 dimer interface [polypeptide binding]; other site 762376011238 conserved gate region; other site 762376011239 putative PBP binding loops; other site 762376011240 ABC-ATPase subunit interface; other site 762376011241 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376011242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011243 dimer interface [polypeptide binding]; other site 762376011244 conserved gate region; other site 762376011245 putative PBP binding loops; other site 762376011246 ABC-ATPase subunit interface; other site 762376011247 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376011248 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376011249 Walker A/P-loop; other site 762376011250 ATP binding site [chemical binding]; other site 762376011251 Q-loop/lid; other site 762376011252 ABC transporter signature motif; other site 762376011253 Walker B; other site 762376011254 D-loop; other site 762376011255 H-loop/switch region; other site 762376011256 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011257 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376011258 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376011259 Walker A/P-loop; other site 762376011260 ATP binding site [chemical binding]; other site 762376011261 Q-loop/lid; other site 762376011262 ABC transporter signature motif; other site 762376011263 Walker B; other site 762376011264 D-loop; other site 762376011265 H-loop/switch region; other site 762376011266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011267 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376011268 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376011269 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 762376011270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376011271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376011272 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376011273 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376011274 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376011275 LysE type translocator; Region: LysE; cl00565 762376011276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376011277 Uncharacterized conserved protein [Function unknown]; Region: COG4933 762376011278 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762376011279 putative transposase OrfB; Reviewed; Region: PHA02517 762376011280 Integrase core domain; Region: rve; cl01316 762376011281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011285 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376011286 putative dimerization interface [polypeptide binding]; other site 762376011287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011290 dimerization interface [polypeptide binding]; other site 762376011291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 762376011292 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376011293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011295 dimerization interface [polypeptide binding]; other site 762376011296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011297 D-galactonate transporter; Region: 2A0114; TIGR00893 762376011298 putative substrate translocation pore; other site 762376011299 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376011300 classical (c) SDRs; Region: SDR_c; cd05233 762376011301 NAD(P) binding site [chemical binding]; other site 762376011302 active site 762376011303 Dehydratase family; Region: ILVD_EDD; cl00340 762376011304 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376011305 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376011306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011307 Isochorismatase family; Region: Isochorismatase; pfam00857 762376011308 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 762376011309 catalytic triad [active] 762376011310 conserved cis-peptide bond; other site 762376011311 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 762376011312 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376011313 conserved cys residue [active] 762376011314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011315 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376011316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376011318 Coenzyme A binding pocket [chemical binding]; other site 762376011319 EamA-like transporter family; Region: EamA; cl01037 762376011320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376011321 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 762376011322 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762376011323 tetramer interface [polypeptide binding]; other site 762376011324 catalytic Zn binding site [ion binding]; other site 762376011325 NADP binding site [chemical binding]; other site 762376011326 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 762376011327 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376011328 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376011329 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376011330 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376011331 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376011332 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43...; Region: PL2_Passenger_AT; cd01344 762376011333 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376011334 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376011335 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376011336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 762376011337 phosphate binding site [ion binding]; other site 762376011338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376011339 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 762376011340 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376011341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011342 DNA-binding site [nucleotide binding]; DNA binding site 762376011343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376011344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011345 homodimer interface [polypeptide binding]; other site 762376011346 catalytic residue [active] 762376011347 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376011348 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376011349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376011350 catalytic loop [active] 762376011351 iron binding site [ion binding]; other site 762376011352 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 762376011353 FAD binding pocket [chemical binding]; other site 762376011354 conserved FAD binding motif [chemical binding]; other site 762376011355 phosphate binding motif [ion binding]; other site 762376011356 beta-alpha-beta structure motif; other site 762376011357 NAD binding pocket [chemical binding]; other site 762376011358 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 762376011359 active site 762376011360 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 762376011361 B12 binding site [chemical binding]; other site 762376011362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376011363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376011364 metal binding site [ion binding]; metal-binding site 762376011365 active site 762376011366 I-site; other site 762376011367 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 762376011368 active site 762376011369 substrate binding site [chemical binding]; other site 762376011370 Mg2+ binding site [ion binding]; other site 762376011371 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762376011372 dimer interface [polypeptide binding]; other site 762376011373 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 762376011374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376011375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376011376 metal binding site [ion binding]; metal-binding site 762376011377 active site 762376011378 I-site; other site 762376011379 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376011380 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762376011381 nucleoside/Zn binding site; other site 762376011382 dimer interface [polypeptide binding]; other site 762376011383 catalytic motif [active] 762376011384 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 762376011385 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 762376011386 putative active site [active] 762376011387 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376011388 FAD binding domain; Region: FAD_binding_4; pfam01565 762376011389 Berberine and berberine like; Region: BBE; pfam08031 762376011390 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762376011391 hypothetical protein; Provisional; Region: PRK06184 762376011392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376011393 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376011394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011396 dimerization interface [polypeptide binding]; other site 762376011397 Sulfatase; Region: Sulfatase; cl10460 762376011398 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376011399 Cupin domain; Region: Cupin_2; cl09118 762376011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011402 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 762376011403 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762376011404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376011405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011407 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 762376011408 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 762376011409 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 762376011410 metal binding site [ion binding]; metal-binding site 762376011411 putative dimer interface [polypeptide binding]; other site 762376011412 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376011413 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376011414 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376011415 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376011416 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376011417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376011418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376011419 fec operon regulator FecR; Reviewed; Region: PRK09774 762376011420 FecR protein; Region: FecR; pfam04773 762376011421 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376011422 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376011423 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376011424 N-terminal plug; other site 762376011425 ligand-binding site [chemical binding]; other site 762376011426 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 762376011427 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 762376011428 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 762376011429 dimerization interface [polypeptide binding]; other site 762376011430 ATP binding site [chemical binding]; other site 762376011431 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 762376011432 dimerization interface [polypeptide binding]; other site 762376011433 ATP binding site [chemical binding]; other site 762376011434 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762376011435 putative active site [active] 762376011436 catalytic triad [active] 762376011437 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376011438 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376011439 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376011440 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 762376011441 domain; Region: GreA_GreB_N; pfam03449 762376011442 C-term; Region: GreA_GreB; pfam01272 762376011443 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 762376011444 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 762376011445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376011446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376011447 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 762376011448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376011449 S-adenosylmethionine binding site [chemical binding]; other site 762376011450 choline dehydrogenase; Validated; Region: PRK02106 762376011451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376011452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376011453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376011454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011457 dimerization interface [polypeptide binding]; other site 762376011458 nitrite reductase subunit NirD; Provisional; Region: PRK14989 762376011459 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 762376011460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376011461 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 762376011462 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 762376011463 Predicted integral membrane protein [Function unknown]; Region: COG5616 762376011464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376011465 TPR motif; other site 762376011466 binding surface 762376011467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376011468 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 762376011469 homodimer interface [polypeptide binding]; other site 762376011470 substrate-cofactor binding pocket; other site 762376011471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011472 Aminotransferase class IV; Region: Aminotran_4; pfam01063 762376011473 catalytic residue [active] 762376011474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376011475 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376011476 Walker A/P-loop; other site 762376011477 ATP binding site [chemical binding]; other site 762376011478 Q-loop/lid; other site 762376011479 ABC transporter signature motif; other site 762376011480 Walker B; other site 762376011481 D-loop; other site 762376011482 H-loop/switch region; other site 762376011483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011484 putative PBP binding loops; other site 762376011485 dimer interface [polypeptide binding]; other site 762376011486 ABC-ATPase subunit interface; other site 762376011487 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376011488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011489 dimer interface [polypeptide binding]; other site 762376011490 conserved gate region; other site 762376011491 putative PBP binding loops; other site 762376011492 ABC-ATPase subunit interface; other site 762376011493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376011494 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376011495 substrate binding pocket [chemical binding]; other site 762376011496 membrane-bound complex binding site; other site 762376011497 hinge residues; other site 762376011498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011501 dimerization interface [polypeptide binding]; other site 762376011502 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 762376011503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376011504 DNA binding site [nucleotide binding] 762376011505 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 762376011506 putative ligand binding site [chemical binding]; other site 762376011507 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376011508 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376011509 DctM-like transporters; Region: DctM; pfam06808 762376011510 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376011511 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 762376011512 dimer interface [polypeptide binding]; other site 762376011513 substrate binding site [chemical binding]; other site 762376011514 metal binding site [ion binding]; metal-binding site 762376011515 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 762376011516 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 762376011517 dimer interface [polypeptide binding]; other site 762376011518 active site 762376011519 catalytic residue [active] 762376011520 metal binding site [ion binding]; metal-binding site 762376011521 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 762376011522 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376011523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376011524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011525 NAD(P) binding site [chemical binding]; other site 762376011526 active site 762376011527 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376011528 active site 762376011529 catalytic site [active] 762376011530 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376011531 active site 762376011532 catalytic site [active] 762376011533 lipid-transfer protein; Provisional; Region: PRK08256 762376011534 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376011535 active site 762376011536 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376011537 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376011538 FMN binding site [chemical binding]; other site 762376011539 substrate binding site [chemical binding]; other site 762376011540 putative catalytic residue [active] 762376011541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376011542 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 762376011543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376011544 DNA binding residues [nucleotide binding] 762376011545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011547 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376011548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376011549 active site 762376011550 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376011551 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376011552 active site 762376011553 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376011554 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376011555 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376011556 substrate binding site [chemical binding]; other site 762376011557 oxyanion hole (OAH) forming residues; other site 762376011558 trimer interface [polypeptide binding]; other site 762376011559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011561 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376011562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376011563 substrate binding site [chemical binding]; other site 762376011564 oxyanion hole (OAH) forming residues; other site 762376011565 trimer interface [polypeptide binding]; other site 762376011566 hypothetical protein; Provisional; Region: PRK08204 762376011567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376011568 active site 762376011569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011571 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376011572 trimer interface [polypeptide binding]; other site 762376011573 eyelet of channel; other site 762376011574 hypothetical protein; Provisional; Region: PRK08204 762376011575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376011576 active site 762376011577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011579 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011580 putative effector binding pocket; other site 762376011581 dimerization interface [polypeptide binding]; other site 762376011582 Gram-negative bacterial tonB protein; Region: TonB; cl10048 762376011583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376011584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011585 DNA-binding site [nucleotide binding]; DNA binding site 762376011586 FCD domain; Region: FCD; cl11656 762376011587 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376011588 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376011589 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 762376011590 active site 762376011591 NAD binding site [chemical binding]; other site 762376011592 metal binding site [ion binding]; metal-binding site 762376011593 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376011594 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376011595 tetramerization interface [polypeptide binding]; other site 762376011596 NAD(P) binding site [chemical binding]; other site 762376011597 catalytic residues [active] 762376011598 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762376011599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011601 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 762376011602 Competence protein; Region: Competence; cl00471 762376011603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376011604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011605 NAD(P) binding site [chemical binding]; other site 762376011606 active site 762376011607 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376011608 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376011609 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376011610 active site 762376011611 catalytic site [active] 762376011612 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376011613 active site 762376011614 catalytic site [active] 762376011615 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376011616 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376011617 thiolase; Provisional; Region: PRK06158 762376011618 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376011619 active site 762376011620 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 762376011621 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376011622 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376011623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376011624 active site 762376011625 metal binding site [ion binding]; metal-binding site 762376011626 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 762376011627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376011628 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376011629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011630 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376011631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376011632 dimer interface [polypeptide binding]; other site 762376011633 conserved gate region; other site 762376011634 ABC-ATPase subunit interface; other site 762376011635 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376011636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376011637 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376011638 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376011639 Walker A/P-loop; other site 762376011640 ATP binding site [chemical binding]; other site 762376011641 Q-loop/lid; other site 762376011642 ABC transporter signature motif; other site 762376011643 Walker B; other site 762376011644 D-loop; other site 762376011645 H-loop/switch region; other site 762376011646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376011649 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376011650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376011651 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 762376011652 [2Fe-2S] cluster binding site [ion binding]; other site 762376011653 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376011654 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 762376011655 iron-sulfur cluster [ion binding]; other site 762376011656 [2Fe-2S] cluster binding site [ion binding]; other site 762376011657 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376011658 putative alpha subunit interface [polypeptide binding]; other site 762376011659 putative active site [active] 762376011660 putative substrate binding site [chemical binding]; other site 762376011661 Fe binding site [ion binding]; other site 762376011662 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376011663 inter-subunit interface; other site 762376011664 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 762376011665 Cupin domain; Region: Cupin_2; cl09118 762376011666 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 762376011667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011668 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376011669 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376011670 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376011671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011672 DNA-binding site [nucleotide binding]; DNA binding site 762376011673 FCD domain; Region: FCD; cl11656 762376011674 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 762376011675 substrate binding site [chemical binding]; other site 762376011676 multimerization interface [polypeptide binding]; other site 762376011677 ATP binding site [chemical binding]; other site 762376011678 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376011679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376011680 N-terminal plug; other site 762376011681 ligand-binding site [chemical binding]; other site 762376011682 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 762376011683 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 762376011684 active site 762376011685 metal binding site [ion binding]; metal-binding site 762376011686 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376011687 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 762376011688 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376011689 Walker A/P-loop; other site 762376011690 ATP binding site [chemical binding]; other site 762376011691 Q-loop/lid; other site 762376011692 ABC transporter signature motif; other site 762376011693 Walker B; other site 762376011694 D-loop; other site 762376011695 H-loop/switch region; other site 762376011696 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 762376011697 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376011698 ABC-ATPase subunit interface; other site 762376011699 dimer interface [polypeptide binding]; other site 762376011700 putative PBP binding regions; other site 762376011701 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 762376011702 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376011703 ABC-ATPase subunit interface; other site 762376011704 dimer interface [polypeptide binding]; other site 762376011705 putative PBP binding regions; other site 762376011706 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 762376011707 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762376011708 putative ligand binding residues [chemical binding]; other site 762376011709 enterobactin receptor protein; Provisional; Region: PRK13483 762376011710 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376011711 N-terminal plug; other site 762376011712 ligand-binding site [chemical binding]; other site 762376011713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376011714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376011715 active site 762376011716 phosphorylation site [posttranslational modification] 762376011717 intermolecular recognition site; other site 762376011718 dimerization interface [polypeptide binding]; other site 762376011719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376011720 DNA binding site [nucleotide binding] 762376011721 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376011722 dimerization interface [polypeptide binding]; other site 762376011723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376011724 dimer interface [polypeptide binding]; other site 762376011725 phosphorylation site [posttranslational modification] 762376011726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376011727 ATP binding site [chemical binding]; other site 762376011728 Mg2+ binding site [ion binding]; other site 762376011729 G-X-G motif; other site 762376011730 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762376011731 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 762376011732 active site 762376011733 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 762376011734 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762376011735 Walker A/P-loop; other site 762376011736 ATP binding site [chemical binding]; other site 762376011737 Q-loop/lid; other site 762376011738 ABC transporter signature motif; other site 762376011739 Walker B; other site 762376011740 D-loop; other site 762376011741 H-loop/switch region; other site 762376011742 LolC/E family; Region: lolCE; TIGR02212 762376011743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762376011744 FtsX-like permease family; Region: FtsX; pfam02687 762376011745 Sulfatase; Region: Sulfatase; cl10460 762376011746 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 762376011747 DHH family; Region: DHH; pfam01368 762376011748 DHHA1 domain; Region: DHHA1; pfam02272 762376011749 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376011750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011751 putative substrate translocation pore; other site 762376011752 peptide chain release factor 2; Provisional; Region: PRK08787 762376011753 RF-1 domain; Region: RF-1; cl02875 762376011754 RF-1 domain; Region: RF-1; cl02875 762376011755 short chain dehydrogenase; Provisional; Region: PRK06924 762376011756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011757 NAD(P) binding site [chemical binding]; other site 762376011758 active site 762376011759 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762376011760 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 762376011761 dimer interface [polypeptide binding]; other site 762376011762 putative anticodon binding site; other site 762376011763 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762376011764 motif 1; other site 762376011765 active site 762376011766 motif 2; other site 762376011767 motif 3; other site 762376011768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376011769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011770 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 762376011771 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376011772 dimer interface [polypeptide binding]; other site 762376011773 active site 762376011774 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762376011775 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376011776 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376011777 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376011778 Walker A/P-loop; other site 762376011779 ATP binding site [chemical binding]; other site 762376011780 Q-loop/lid; other site 762376011781 ABC transporter signature motif; other site 762376011782 Walker B; other site 762376011783 D-loop; other site 762376011784 H-loop/switch region; other site 762376011785 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 762376011786 putative ligand binding site [chemical binding]; other site 762376011787 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376011788 TM-ABC transporter signature motif; other site 762376011789 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376011790 TM-ABC transporter signature motif; other site 762376011791 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376011792 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376011793 Walker A/P-loop; other site 762376011794 ATP binding site [chemical binding]; other site 762376011795 Q-loop/lid; other site 762376011796 ABC transporter signature motif; other site 762376011797 Walker B; other site 762376011798 D-loop; other site 762376011799 H-loop/switch region; other site 762376011800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376011801 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376011802 substrate binding site [chemical binding]; other site 762376011803 oxyanion hole (OAH) forming residues; other site 762376011804 trimer interface [polypeptide binding]; other site 762376011805 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376011806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376011807 substrate binding site [chemical binding]; other site 762376011808 oxyanion hole (OAH) forming residues; other site 762376011809 trimer interface [polypeptide binding]; other site 762376011810 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376011811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011813 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 762376011814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011815 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376011816 putative dimerization interface [polypeptide binding]; other site 762376011817 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 762376011818 active site 762376011819 dimer interfaces [polypeptide binding]; other site 762376011820 catalytic residues [active] 762376011821 Protein of unknown function (DUF528); Region: DUF528; cl01123 762376011822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 762376011823 chaperone protein HscA; Provisional; Region: hscA; PRK05183 762376011824 co-chaperone HscB; Provisional; Region: hscB; PRK03578 762376011825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 762376011826 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 762376011827 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 762376011828 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762376011829 trimerization site [polypeptide binding]; other site 762376011830 active site 762376011831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762376011832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376011833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376011834 catalytic residue [active] 762376011835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011836 Rrf2 family protein; Region: rrf2_super; TIGR00738 762376011837 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376011838 Active site [active] 762376011839 excinuclease ABC subunit B; Provisional; Region: PRK05298 762376011840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376011841 ATP binding site [chemical binding]; other site 762376011842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376011843 nucleotide binding region [chemical binding]; other site 762376011844 ATP-binding site [chemical binding]; other site 762376011845 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762376011846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376011847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011848 homodimer interface [polypeptide binding]; other site 762376011849 catalytic residue [active] 762376011850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011851 LexA repressor; Validated; Region: PRK00215 762376011852 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 762376011853 Catalytic site [active] 762376011854 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 762376011855 Found in ATP-dependent protease La (LON); Region: LON; cl01056 762376011856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376011857 Walker A motif; other site 762376011858 ATP binding site [chemical binding]; other site 762376011859 Walker B motif; other site 762376011860 arginine finger; other site 762376011861 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762376011862 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762376011863 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762376011864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376011865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376011866 Walker A motif; other site 762376011867 ATP binding site [chemical binding]; other site 762376011868 Walker B motif; other site 762376011869 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376011870 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762376011871 oligomer interface [polypeptide binding]; other site 762376011872 active site residues [active] 762376011873 trigger factor; Provisional; Region: tig; PRK01490 762376011874 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 762376011875 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762376011876 Peptidase family M48; Region: Peptidase_M48; cl12018 762376011877 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 762376011878 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376011879 DNA-binding site [nucleotide binding]; DNA binding site 762376011880 RNA-binding motif; other site 762376011881 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 762376011882 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376011883 DNA-binding site [nucleotide binding]; DNA binding site 762376011884 RNA-binding motif; other site 762376011885 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 762376011886 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376011887 homotrimer interaction site [polypeptide binding]; other site 762376011888 putative active site [active] 762376011889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 762376011890 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376011891 active site 762376011892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376011893 dimer interface [polypeptide binding]; other site 762376011894 substrate binding site [chemical binding]; other site 762376011895 catalytic residue [active] 762376011896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376011898 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376011899 putative effector binding pocket; other site 762376011900 putative dimerization interface [polypeptide binding]; other site 762376011901 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376011902 homotrimer interaction site [polypeptide binding]; other site 762376011903 putative active site [active] 762376011904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011906 putative substrate translocation pore; other site 762376011907 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 762376011908 mce related protein; Region: MCE; cl03606 762376011909 mce related protein; Region: MCE; cl03606 762376011910 mce related protein; Region: MCE; cl03606 762376011911 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376011912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376011913 Coenzyme A binding pocket [chemical binding]; other site 762376011914 NeuB family; Region: NeuB; cl00496 762376011915 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376011916 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 762376011917 MgtC family; Region: MgtC; cl12207 762376011918 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 762376011919 amphipathic channel; other site 762376011920 Asn-Pro-Ala signature motifs; other site 762376011921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 762376011922 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 762376011923 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 762376011924 Phage holin family 2; Region: Phage_holin_2; pfam04550 762376011925 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 762376011926 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 762376011927 Phage-related minor tail protein [Function unknown]; Region: COG5281 762376011928 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 762376011929 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 762376011930 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 762376011931 Phage tail protein; Region: Phage_tail_3; pfam08813 762376011932 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 762376011933 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 762376011934 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 762376011935 oligomerization interface [polypeptide binding]; other site 762376011936 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 762376011937 Phage capsid family; Region: Phage_capsid; pfam05065 762376011938 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 762376011939 oligomer interface [polypeptide binding]; other site 762376011940 active site residues [active] 762376011941 Phage portal protein; Region: Phage_portal; pfam04860 762376011942 Phage-related protein [Function unknown]; Region: COG4695; cl01923 762376011943 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 762376011944 Phage Terminase; Region: Terminase_1; pfam03354 762376011945 Terminase small subunit; Region: Terminase_2; cl01513 762376011946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 762376011947 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 762376011948 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 762376011949 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 762376011950 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 762376011951 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 762376011952 Catalytic site [active] 762376011953 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376011954 DNA-binding site [nucleotide binding]; DNA binding site 762376011955 RNA-binding motif; other site 762376011956 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 762376011957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376011958 DNA binding site [nucleotide binding] 762376011959 Int/Topo IB signature motif; other site 762376011960 active site 762376011961 aspartate aminotransferase; Provisional; Region: PRK07681 762376011962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376011963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011964 homodimer interface [polypeptide binding]; other site 762376011965 catalytic residue [active] 762376011966 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 762376011967 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 762376011968 trimer interface [polypeptide binding]; other site 762376011969 active site 762376011970 substrate binding site [chemical binding]; other site 762376011971 CoA binding site [chemical binding]; other site 762376011972 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 762376011973 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 762376011974 metal binding site [ion binding]; metal-binding site 762376011975 dimer interface [polypeptide binding]; other site 762376011976 HemK family putative methylases; Region: hemK_fam; TIGR00536 762376011977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376011978 S-adenosylmethionine binding site [chemical binding]; other site 762376011979 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 762376011980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376011981 Walker A/P-loop; other site 762376011982 ATP binding site [chemical binding]; other site 762376011983 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376011984 ABC transporter; Region: ABC_tran_2; pfam12848 762376011985 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762376011986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376011987 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376011988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376011989 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376011990 FecR protein; Region: FecR; pfam04773 762376011991 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 762376011992 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376011993 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 762376011994 Chorismate mutase type II; Region: CM_2; cl00693 762376011995 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 762376011996 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376011997 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376011998 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 762376011999 Di-iron ligands [ion binding]; other site 762376012000 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 762376012001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012002 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762376012003 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762376012004 active site 762376012005 substrate binding site [chemical binding]; other site 762376012006 cosubstrate binding site; other site 762376012007 catalytic site [active] 762376012008 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762376012009 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762376012010 active site 762376012011 Riboflavin kinase; Region: Flavokinase; pfam01687 762376012012 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 762376012013 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376012014 active site 762376012015 HIGH motif; other site 762376012016 nucleotide binding site [chemical binding]; other site 762376012017 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762376012018 active site 762376012019 KMSKS motif; other site 762376012020 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 762376012021 tRNA binding surface [nucleotide binding]; other site 762376012022 anticodon binding site; other site 762376012023 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762376012024 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 762376012025 lipoprotein signal peptidase; Provisional; Region: PRK14787 762376012026 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762376012027 Flavoprotein; Region: Flavoprotein; cl08021 762376012028 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 762376012029 Cation efflux family; Region: Cation_efflux; cl00316 762376012030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012032 AroM protein; Region: AroM; cl06364 762376012033 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 762376012034 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 762376012035 active site pocket [active] 762376012036 oxyanion hole [active] 762376012037 catalytic triad [active] 762376012038 active site nucleophile [active] 762376012039 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376012040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012041 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376012042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012046 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376012047 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376012048 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 762376012049 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376012050 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376012051 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 762376012052 dUTPase; Region: dUTPase_2; pfam08761 762376012053 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl01578 762376012054 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl01578 762376012055 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl01578 762376012056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012058 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376012059 putative effector binding pocket; other site 762376012060 dimerization interface [polypeptide binding]; other site 762376012061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012063 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376012064 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 762376012065 active site 762376012066 dimer interface [polypeptide binding]; other site 762376012067 metal binding site [ion binding]; metal-binding site 762376012068 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376012069 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376012070 active site 762376012071 FMN binding site [chemical binding]; other site 762376012072 substrate binding site [chemical binding]; other site 762376012073 homotetramer interface [polypeptide binding]; other site 762376012074 catalytic residue [active] 762376012075 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376012076 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376012077 Walker A/P-loop; other site 762376012078 ATP binding site [chemical binding]; other site 762376012079 Q-loop/lid; other site 762376012080 ABC transporter signature motif; other site 762376012081 Walker B; other site 762376012082 D-loop; other site 762376012083 H-loop/switch region; other site 762376012084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012085 dimer interface [polypeptide binding]; other site 762376012086 conserved gate region; other site 762376012087 putative PBP binding loops; other site 762376012088 ABC-ATPase subunit interface; other site 762376012089 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376012090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012091 dimer interface [polypeptide binding]; other site 762376012092 conserved gate region; other site 762376012093 putative PBP binding loops; other site 762376012094 ABC-ATPase subunit interface; other site 762376012095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376012096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376012097 substrate binding pocket [chemical binding]; other site 762376012098 membrane-bound complex binding site; other site 762376012099 hinge residues; other site 762376012100 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376012101 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376012102 putative ligand binding site [chemical binding]; other site 762376012103 OsmC-like protein; Region: OsmC; cl00767 762376012104 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 762376012105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012107 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376012108 putative effector binding pocket; other site 762376012109 dimerization interface [polypeptide binding]; other site 762376012110 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376012111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012113 dimerization interface [polypeptide binding]; other site 762376012114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376012115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376012116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376012117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012118 putative substrate translocation pore; other site 762376012119 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376012120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012121 DNA-binding site [nucleotide binding]; DNA binding site 762376012122 FCD domain; Region: FCD; cl11656 762376012123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012124 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012125 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376012126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376012127 substrate binding site [chemical binding]; other site 762376012128 oxyanion hole (OAH) forming residues; other site 762376012129 trimer interface [polypeptide binding]; other site 762376012130 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376012131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376012132 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376012133 Walker A/P-loop; other site 762376012134 ATP binding site [chemical binding]; other site 762376012135 Q-loop/lid; other site 762376012136 ABC transporter signature motif; other site 762376012137 Walker B; other site 762376012138 D-loop; other site 762376012139 H-loop/switch region; other site 762376012140 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376012141 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376012142 Walker A/P-loop; other site 762376012143 ATP binding site [chemical binding]; other site 762376012144 Q-loop/lid; other site 762376012145 ABC transporter signature motif; other site 762376012146 Walker B; other site 762376012147 D-loop; other site 762376012148 H-loop/switch region; other site 762376012149 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376012150 TM-ABC transporter signature motif; other site 762376012151 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376012152 TM-ABC transporter signature motif; other site 762376012153 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376012154 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376012155 dimerization interface [polypeptide binding]; other site 762376012156 ligand binding site [chemical binding]; other site 762376012157 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 762376012158 Proline dehydrogenase; Region: Pro_dh; cl03282 762376012159 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 762376012160 Glutamate binding site [chemical binding]; other site 762376012161 NAD binding site [chemical binding]; other site 762376012162 catalytic residues [active] 762376012163 Protein of unknown function (DUF330); Region: DUF330; cl01135 762376012164 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 762376012165 mce related protein; Region: MCE; cl03606 762376012166 mce related protein; Region: MCE; cl03606 762376012167 mce related protein; Region: MCE; cl03606 762376012168 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 762376012169 Paraquat-inducible protein A; Region: PqiA; pfam04403 762376012170 Paraquat-inducible protein A; Region: PqiA; pfam04403 762376012171 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 762376012172 Clp amino terminal domain; Region: Clp_N; pfam02861 762376012173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376012174 Walker A motif; other site 762376012175 ATP binding site [chemical binding]; other site 762376012176 Walker B motif; other site 762376012177 arginine finger; other site 762376012178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376012179 Walker A motif; other site 762376012180 ATP binding site [chemical binding]; other site 762376012181 Walker B motif; other site 762376012182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376012183 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 762376012184 Transglycosylase; Region: Transgly; cl07896 762376012185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762376012186 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 762376012187 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 762376012188 MG2 domain; Region: A2M_N; pfam01835 762376012189 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 762376012190 Alpha-2-macroglobulin family; Region: A2M; pfam00207 762376012191 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 762376012192 surface patch; other site 762376012193 thioester region; other site 762376012194 specificity defining residues; other site 762376012195 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 762376012196 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376012197 DNA-binding site [nucleotide binding]; DNA binding site 762376012198 RNA-binding motif; other site 762376012199 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 762376012200 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 762376012201 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376012202 dimer interface [polypeptide binding]; other site 762376012203 active site 762376012204 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 762376012205 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 762376012206 putative ion selectivity filter; other site 762376012207 putative pore gating glutamate residue; other site 762376012208 putative H+/Cl- coupling transport residue; other site 762376012209 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 762376012210 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 762376012211 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376012212 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376012213 superoxide dismutase; Provisional; Region: PRK10543 762376012214 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762376012215 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762376012216 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762376012217 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 762376012218 generic binding surface II; other site 762376012219 generic binding surface I; other site 762376012220 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762376012221 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376012222 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 762376012223 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 762376012224 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 762376012225 Trm112p-like protein; Region: Trm112p; cl01066 762376012226 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 762376012227 Ligand binding site [chemical binding]; other site 762376012228 oligomer interface [polypeptide binding]; other site 762376012229 adenylate kinase; Reviewed; Region: adk; PRK00279 762376012230 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762376012231 AMP-binding site [chemical binding]; other site 762376012232 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762376012233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376012234 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 762376012235 NAD binding site [chemical binding]; other site 762376012236 homotetramer interface [polypeptide binding]; other site 762376012237 homodimer interface [polypeptide binding]; other site 762376012238 active site 762376012239 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 762376012240 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376012241 FecR protein; Region: FecR; pfam04773 762376012242 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 762376012243 transcriptional regulator; Provisional; Region: PRK10632 762376012244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012245 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376012246 putative effector binding pocket; other site 762376012247 dimerization interface [polypeptide binding]; other site 762376012248 choline dehydrogenase; Validated; Region: PRK02106 762376012249 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 762376012250 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376012251 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376012252 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 762376012253 NAD(P) binding site [chemical binding]; other site 762376012254 catalytic residues [active] 762376012255 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 762376012256 heme binding pocket [chemical binding]; other site 762376012257 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376012258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012260 dimerization interface [polypeptide binding]; other site 762376012261 diaminopimelate decarboxylase; Provisional; Region: PRK11165 762376012262 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762376012263 active site 762376012264 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376012265 substrate binding site [chemical binding]; other site 762376012266 catalytic residues [active] 762376012267 dimer interface [polypeptide binding]; other site 762376012268 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376012269 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 762376012270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012271 Dehydratase family; Region: ILVD_EDD; cl00340 762376012272 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376012273 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376012274 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376012275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012276 DNA-binding site [nucleotide binding]; DNA binding site 762376012277 FCD domain; Region: FCD; cl11656 762376012278 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376012279 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376012280 inhibitor site; inhibition site 762376012281 active site 762376012282 dimer interface [polypeptide binding]; other site 762376012283 catalytic residue [active] 762376012284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012288 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376012289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012290 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 762376012291 DNA repair protein RadA; Provisional; Region: PRK11823 762376012292 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762376012293 Walker A motif/ATP binding site; other site 762376012294 ATP binding site [chemical binding]; other site 762376012295 Walker B motif; other site 762376012296 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762376012297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012298 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376012299 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 762376012300 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376012301 putative active site [active] 762376012302 putative metal binding site [ion binding]; other site 762376012303 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376012304 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376012305 NAD binding site [chemical binding]; other site 762376012306 catalytic residues [active] 762376012307 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 762376012308 putative substrate binding pocket [chemical binding]; other site 762376012309 trimer interface [polypeptide binding]; other site 762376012310 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376012311 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 762376012312 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376012313 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376012314 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 762376012315 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376012316 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376012317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376012320 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376012321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012323 dimerization interface [polypeptide binding]; other site 762376012324 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376012325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012327 dimerization interface [polypeptide binding]; other site 762376012328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376012329 classical (c) SDRs; Region: SDR_c; cd05233 762376012330 NAD(P) binding site [chemical binding]; other site 762376012331 active site 762376012332 alanine racemase; Reviewed; Region: alr; PRK00053 762376012333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 762376012334 active site 762376012335 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376012336 substrate binding site [chemical binding]; other site 762376012337 catalytic residues [active] 762376012338 dimer interface [polypeptide binding]; other site 762376012339 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 762376012340 active site lid residues [active] 762376012341 substrate binding pocket [chemical binding]; other site 762376012342 catalytic residues [active] 762376012343 substrate-Mg2+ binding site; other site 762376012344 aspartate-rich region 1; other site 762376012345 aspartate-rich region 2; other site 762376012346 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 762376012347 active site lid residues [active] 762376012348 substrate binding pocket [chemical binding]; other site 762376012349 catalytic residues [active] 762376012350 substrate-Mg2+ binding site; other site 762376012351 aspartate-rich region 1; other site 762376012352 aspartate-rich region 2; other site 762376012353 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 762376012354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376012355 CrcB-like protein; Region: CRCB; cl09114 762376012356 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 762376012357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 762376012358 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469 762376012359 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 762376012360 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 762376012361 ApbE family; Region: ApbE; cl00643 762376012362 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376012363 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 762376012364 FAD binding pocket [chemical binding]; other site 762376012365 FAD binding motif [chemical binding]; other site 762376012366 catalytic residues [active] 762376012367 NAD binding pocket [chemical binding]; other site 762376012368 phosphate binding motif [ion binding]; other site 762376012369 beta-alpha-beta structure motif; other site 762376012370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012372 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376012373 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376012374 active site 762376012375 putative substrate binding pocket [chemical binding]; other site 762376012376 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376012377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012380 dimerization interface [polypeptide binding]; other site 762376012381 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 762376012382 putative hydrophobic ligand binding site [chemical binding]; other site 762376012383 protein interface [polypeptide binding]; other site 762376012384 gate; other site 762376012385 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 762376012386 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 762376012387 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 762376012388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376012389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376012390 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376012391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012392 DNA-binding site [nucleotide binding]; DNA binding site 762376012393 FCD domain; Region: FCD; cl11656 762376012394 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376012395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012396 hypothetical protein; Validated; Region: PRK06201 762376012397 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 762376012398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012400 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376012401 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 762376012402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012403 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376012404 Sulfatase; Region: Sulfatase; cl10460 762376012405 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376012406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012408 Cupin domain; Region: Cupin_2; cl09118 762376012409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376012410 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 762376012411 NAD(P) binding site [chemical binding]; other site 762376012412 catalytic residues [active] 762376012413 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 762376012414 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 762376012415 dimer interface [polypeptide binding]; other site 762376012416 active site 762376012417 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 762376012418 iron-sulfur cluster [ion binding]; other site 762376012419 [2Fe-2S] cluster binding site [ion binding]; other site 762376012420 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 762376012421 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 762376012422 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 762376012423 Clp amino terminal domain; Region: Clp_N; pfam02861 762376012424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376012425 Walker A motif; other site 762376012426 ATP binding site [chemical binding]; other site 762376012427 Walker B motif; other site 762376012428 arginine finger; other site 762376012429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376012430 Walker A motif; other site 762376012431 ATP binding site [chemical binding]; other site 762376012432 Walker B motif; other site 762376012433 arginine finger; other site 762376012434 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376012435 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376012436 putative active site pocket [active] 762376012437 dimerization interface [polypeptide binding]; other site 762376012438 putative catalytic residue [active] 762376012439 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 762376012440 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376012441 ligand binding site [chemical binding]; other site 762376012442 flexible hinge region; other site 762376012443 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376012444 putative switch regulator; other site 762376012445 non-specific DNA interactions [nucleotide binding]; other site 762376012446 DNA binding site [nucleotide binding] 762376012447 sequence specific DNA binding site [nucleotide binding]; other site 762376012448 putative cAMP binding site [chemical binding]; other site 762376012449 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 762376012450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012451 putative substrate translocation pore; other site 762376012452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376012453 dimerization interface [polypeptide binding]; other site 762376012454 putative DNA binding site [nucleotide binding]; other site 762376012455 putative Zn2+ binding site [ion binding]; other site 762376012456 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 762376012457 putative hydrophobic ligand binding site [chemical binding]; other site 762376012458 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376012459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376012460 catalytic loop [active] 762376012461 iron binding site [ion binding]; other site 762376012462 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 762376012463 dimer interface [polypeptide binding]; other site 762376012464 ADP-ribose binding site [chemical binding]; other site 762376012465 active site 762376012466 nudix motif; other site 762376012467 metal binding site [ion binding]; metal-binding site 762376012468 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 762376012469 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376012470 putative NAD(P) binding site [chemical binding]; other site 762376012471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012474 dimerization interface [polypeptide binding]; other site 762376012475 putative chaperone; Provisional; Region: PRK11678 762376012476 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 762376012477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 762376012478 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376012479 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012480 N-terminal plug; other site 762376012481 ligand-binding site [chemical binding]; other site 762376012482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376012483 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 762376012484 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 762376012485 catalytic triad [active] 762376012486 conserved cis-peptide bond; other site 762376012487 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 762376012488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376012489 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376012490 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376012491 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376012492 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376012493 putative C-terminal domain interface [polypeptide binding]; other site 762376012494 putative GSH binding site (G-site) [chemical binding]; other site 762376012495 putative dimer interface [polypeptide binding]; other site 762376012496 GST_C family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_2; cd03180 762376012497 putative N-terminal domain interface [polypeptide binding]; other site 762376012498 putative dimer interface [polypeptide binding]; other site 762376012499 putative substrate binding pocket (H-site) [chemical binding]; other site 762376012500 OsmC-like protein; Region: OsmC; cl00767 762376012501 Uncharacterized lipoprotein NlpE involved in copper resistance; Region: NlpE; cl01138 762376012502 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376012503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376012504 substrate binding pocket [chemical binding]; other site 762376012505 hinge residues; other site 762376012506 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 762376012507 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 762376012508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376012509 putative active site [active] 762376012510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376012511 heme pocket [chemical binding]; other site 762376012512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376012513 dimer interface [polypeptide binding]; other site 762376012514 phosphorylation site [posttranslational modification] 762376012515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376012516 ATP binding site [chemical binding]; other site 762376012517 G-X-G motif; other site 762376012518 Response regulator receiver domain; Region: Response_reg; pfam00072 762376012519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376012520 active site 762376012521 phosphorylation site [posttranslational modification] 762376012522 intermolecular recognition site; other site 762376012523 dimerization interface [polypeptide binding]; other site 762376012524 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762376012525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376012526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376012527 catalytic residue [active] 762376012528 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376012529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012530 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376012531 trimer interface [polypeptide binding]; other site 762376012532 eyelet of channel; other site 762376012533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376012534 DNA binding site [nucleotide binding] 762376012535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012537 putative transposase OrfB; Reviewed; Region: PHA02517 762376012538 Integrase core domain; Region: rve; cl01316 762376012539 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762376012540 haemagglutination activity domain; Region: Haemagg_act; cl05436 762376012541 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376012542 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376012543 Surface antigen; Region: Bac_surface_Ag; cl03097 762376012544 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 762376012545 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376012546 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376012547 Walker A/P-loop; other site 762376012548 ATP binding site [chemical binding]; other site 762376012549 Q-loop/lid; other site 762376012550 ABC transporter signature motif; other site 762376012551 Walker B; other site 762376012552 D-loop; other site 762376012553 H-loop/switch region; other site 762376012554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376012555 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376012556 Walker A/P-loop; other site 762376012557 ATP binding site [chemical binding]; other site 762376012558 Q-loop/lid; other site 762376012559 ABC transporter signature motif; other site 762376012560 Walker B; other site 762376012561 D-loop; other site 762376012562 H-loop/switch region; other site 762376012563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376012564 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 762376012565 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376012566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376012567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012568 dimer interface [polypeptide binding]; other site 762376012569 conserved gate region; other site 762376012570 putative PBP binding loops; other site 762376012571 ABC-ATPase subunit interface; other site 762376012572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376012573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012574 dimer interface [polypeptide binding]; other site 762376012575 conserved gate region; other site 762376012576 putative PBP binding loops; other site 762376012577 ABC-ATPase subunit interface; other site 762376012578 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_5; cd06232 762376012579 putative active site [active] 762376012580 Zn-binding site [ion binding]; other site 762376012581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376012582 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 762376012583 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376012584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012585 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376012586 lytic murein transglycosylase; Region: MltB_2; TIGR02283 762376012587 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376012588 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762376012589 MatE; Region: MatE; pfam01554 762376012590 MatE; Region: MatE; pfam01554 762376012591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012594 dimerization interface [polypeptide binding]; other site 762376012595 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 762376012596 active site 762376012597 purine riboside binding site [chemical binding]; other site 762376012598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376012599 substrate binding pocket [chemical binding]; other site 762376012600 catalytic triad [active] 762376012601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012602 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376012604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376012605 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376012606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012607 putative substrate translocation pore; other site 762376012608 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 762376012609 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376012610 metal binding site [ion binding]; metal-binding site 762376012611 putative dimer interface [polypeptide binding]; other site 762376012612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376012613 Coenzyme A binding pocket [chemical binding]; other site 762376012614 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 762376012615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012616 Domain of unknown function DUF108; Region: DUF108; pfam01958 762376012617 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 762376012618 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376012619 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 762376012620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376012621 RNA binding surface [nucleotide binding]; other site 762376012622 translation initiation factor Sui1; Validated; Region: PRK06824 762376012623 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 762376012624 Predicted RNA interaction site [nucleotide binding]; other site 762376012625 putative binding site; other site 762376012626 Mutations affecting start-site selection; other site 762376012627 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 762376012628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376012629 Active site [active] 762376012630 methionine gamma-lyase; Provisional; Region: PRK07503 762376012631 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376012632 homodimer interface [polypeptide binding]; other site 762376012633 substrate-cofactor binding pocket; other site 762376012634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012635 catalytic residue [active] 762376012636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012637 dimer interface [polypeptide binding]; other site 762376012638 conserved gate region; other site 762376012639 ABC-ATPase subunit interface; other site 762376012640 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762376012641 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 762376012642 Walker A/P-loop; other site 762376012643 ATP binding site [chemical binding]; other site 762376012644 Q-loop/lid; other site 762376012645 ABC transporter signature motif; other site 762376012646 Walker B; other site 762376012647 D-loop; other site 762376012648 H-loop/switch region; other site 762376012649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012650 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 762376012651 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 762376012652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376012654 putative substrate translocation pore; other site 762376012655 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376012656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012657 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 762376012658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012659 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 762376012660 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376012661 Beta-lactamase; Region: Beta-lactamase; cl01009 762376012662 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376012663 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 762376012664 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376012665 Phd_YefM; Region: PhdYeFM; cl09153 762376012666 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 762376012667 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 762376012668 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 762376012669 active site 762376012670 catalytic residues [active] 762376012671 metal binding site [ion binding]; metal-binding site 762376012672 DmpG-like communication domain; Region: DmpG_comm; pfam07836 762376012673 acetaldehyde dehydrogenase; Validated; Region: PRK08300 762376012674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012675 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 762376012676 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376012677 DctM-like transporters; Region: DctM; pfam06808 762376012678 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376012679 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376012680 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376012681 FAD binding domain; Region: FAD_binding_4; pfam01565 762376012682 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376012683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012684 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376012685 L-aspartate oxidase; Provisional; Region: PRK09077 762376012686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376012687 domain; Region: Succ_DH_flav_C; pfam02910 762376012688 Quinolinate synthetase A protein; Region: NadA; cl00420 762376012689 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376012690 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762376012691 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 762376012692 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 762376012693 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 762376012694 NodT family; Region: outer_NodT; TIGR01845 762376012695 Outer membrane efflux protein; Region: OEP; pfam02321 762376012696 Outer membrane efflux protein; Region: OEP; pfam02321 762376012697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376012698 Active site [active] 762376012699 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 762376012700 putative hydrophobic ligand binding site [chemical binding]; other site 762376012701 tellurite resistance protein TehB; Provisional; Region: PRK12335 762376012702 Domain of unknown function (DU1801); Region: DUF1801; cl01838 762376012703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376012706 dimerization interface [polypeptide binding]; other site 762376012707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012709 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376012710 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376012711 active site 762376012712 putative substrate binding pocket [chemical binding]; other site 762376012713 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376012714 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376012715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012718 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376012719 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 762376012720 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762376012721 active site 762376012722 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376012723 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 762376012724 conserved cys residue [active] 762376012725 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 762376012726 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 762376012727 putative dimer interface [polypeptide binding]; other site 762376012728 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 762376012729 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 762376012730 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376012731 Haemolysin-III related; Region: HlyIII; cl03831 762376012732 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 762376012733 Cupin domain; Region: Cupin_2; cl09118 762376012734 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376012735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376012736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376012737 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376012738 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 762376012739 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 762376012740 DNA binding residues [nucleotide binding] 762376012741 putative dimer interface [polypeptide binding]; other site 762376012742 putative metal binding residues [ion binding]; other site 762376012743 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 762376012744 N-acetyltransferase; Region: Acetyltransf_2; cl00949 762376012745 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH...; Region: GST_N_etherase_LigE; cd03038 762376012746 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376012747 putative C-terminal domain interface [polypeptide binding]; other site 762376012748 putative GSH binding site (G-site) [chemical binding]; other site 762376012749 putative dimer interface [polypeptide binding]; other site 762376012750 GST_C family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH...; Region: GST_C_etherase_LigE; cd03202 762376012751 putative dimer interface [polypeptide binding]; other site 762376012752 putative lignin/substrate binding pocket (H-site); other site 762376012753 putative N-terminal domain interface [polypeptide binding]; other site 762376012754 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376012755 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376012756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376012757 Walker A/P-loop; other site 762376012758 ATP binding site [chemical binding]; other site 762376012759 Q-loop/lid; other site 762376012760 ABC transporter signature motif; other site 762376012761 Walker B; other site 762376012762 D-loop; other site 762376012763 H-loop/switch region; other site 762376012764 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376012765 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376012766 inhibitor site; inhibition site 762376012767 active site 762376012768 dimer interface [polypeptide binding]; other site 762376012769 catalytic residue [active] 762376012770 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 762376012771 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_2; cd03327 762376012772 putative active site pocket [active] 762376012773 putative metal binding site [ion binding]; other site 762376012774 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376012775 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 762376012776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012778 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376012779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012780 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 762376012781 putative dimerization interface [polypeptide binding]; other site 762376012782 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 762376012783 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 762376012784 PhnA protein; Region: PhnA; pfam03831 762376012785 FixH; Region: FixH; cl01254 762376012786 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 762376012787 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376012788 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 762376012789 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 762376012790 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 762376012791 Cytochrome c; Region: Cytochrom_C; cl11414 762376012792 Cytochrome c; Region: Cytochrom_C; cl11414 762376012793 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 762376012794 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 762376012795 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 762376012796 Low-spin heme binding site [chemical binding]; other site 762376012797 Putative water exit pathway; other site 762376012798 Binuclear center (active site) [active] 762376012799 Putative proton exit pathway; other site 762376012800 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 762376012801 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376012802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376012803 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376012804 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 762376012805 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376012806 inhibitor-cofactor binding pocket; inhibition site 762376012807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012808 catalytic residue [active] 762376012809 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 762376012810 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376012811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376012812 catalytic residue [active] 762376012813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376012814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012815 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 762376012816 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 762376012817 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376012818 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376012819 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376012820 tetramer interface [polypeptide binding]; other site 762376012821 active site 762376012822 Mg2+/Mn2+ binding site [ion binding]; other site 762376012823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 762376012824 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 762376012825 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 762376012826 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 762376012827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012828 putative substrate translocation pore; other site 762376012829 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762376012830 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762376012831 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 762376012832 UvrB/uvrC motif; Region: UVR; pfam02151 762376012833 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762376012834 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 762376012835 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 762376012836 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 762376012837 active site 762376012838 hydrophilic channel; other site 762376012839 dimerization interface [polypeptide binding]; other site 762376012840 catalytic residues [active] 762376012841 active site lid [active] 762376012842 NodT family; Region: outer_NodT; TIGR01845 762376012843 Outer membrane efflux protein; Region: OEP; pfam02321 762376012844 Outer membrane efflux protein; Region: OEP; pfam02321 762376012845 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376012846 Protein export membrane protein; Region: SecD_SecF; cl14618 762376012847 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376012848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 762376012849 DNA binding site [nucleotide binding] 762376012850 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 762376012851 Patatin phospholipase; Region: DUF3734; pfam12536 762376012852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012853 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 762376012854 TOBE domain; Region: TOBE_2; cl01440 762376012855 TOBE domain; Region: TOBE_2; cl01440 762376012856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376012857 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 762376012858 Walker A/P-loop; other site 762376012859 ATP binding site [chemical binding]; other site 762376012860 Q-loop/lid; other site 762376012861 ABC transporter signature motif; other site 762376012862 Walker B; other site 762376012863 D-loop; other site 762376012864 H-loop/switch region; other site 762376012865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376012866 putative PBP binding loops; other site 762376012867 ABC-ATPase subunit interface; other site 762376012868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012869 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 762376012870 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 762376012871 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 762376012872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012873 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 762376012874 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 762376012875 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376012876 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376012877 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376012878 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376012879 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 762376012880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376012881 Walker A/P-loop; other site 762376012882 ATP binding site [chemical binding]; other site 762376012883 Q-loop/lid; other site 762376012884 ABC transporter signature motif; other site 762376012885 Walker B; other site 762376012886 D-loop; other site 762376012887 H-loop/switch region; other site 762376012888 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 762376012889 TM-ABC transporter signature motif; other site 762376012890 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 762376012891 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 762376012892 zinc binding site [ion binding]; other site 762376012893 putative ligand binding site [chemical binding]; other site 762376012894 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376012895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376012896 active site 762376012897 catalytic tetrad [active] 762376012898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012900 malonyl-CoA synthase; Validated; Region: PRK07514 762376012901 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376012902 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376012903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376012904 substrate binding site [chemical binding]; other site 762376012905 oxyanion hole (OAH) forming residues; other site 762376012906 trimer interface [polypeptide binding]; other site 762376012907 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 762376012908 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376012909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012910 DNA-binding site [nucleotide binding]; DNA binding site 762376012911 FCD domain; Region: FCD; cl11656 762376012912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376012913 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376012914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376012915 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376012916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376012917 active site 762376012918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012920 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 762376012921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012922 enoyl-CoA hydratase; Provisional; Region: PRK08290 762376012923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376012924 substrate binding site [chemical binding]; other site 762376012925 oxyanion hole (OAH) forming residues; other site 762376012926 trimer interface [polypeptide binding]; other site 762376012927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376012928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012929 beta-ketothiolase; Provisional; Region: PRK09051 762376012930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376012931 dimer interface [polypeptide binding]; other site 762376012932 active site 762376012933 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376012934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376012935 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376012936 dimerization interface [polypeptide binding]; other site 762376012937 substrate binding pocket [chemical binding]; other site 762376012938 FOG: CBS domain [General function prediction only]; Region: COG0517 762376012939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 762376012940 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 762376012941 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 762376012942 substrate binding site [chemical binding]; other site 762376012943 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 762376012944 substrate binding site [chemical binding]; other site 762376012945 ligand binding site [chemical binding]; other site 762376012946 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376012947 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376012948 catalytic residue [active] 762376012949 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376012950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012951 N-terminal plug; other site 762376012952 ligand-binding site [chemical binding]; other site 762376012953 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376012954 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376012955 MlrC C-terminus; Region: MlrC_C; pfam07171 762376012956 allantoate amidohydrolase; Reviewed; Region: PRK09290 762376012957 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376012958 active site 762376012959 metal binding site [ion binding]; metal-binding site 762376012960 dimer interface [polypeptide binding]; other site 762376012961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376012962 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376012963 Walker A/P-loop; other site 762376012964 ATP binding site [chemical binding]; other site 762376012965 Q-loop/lid; other site 762376012966 ABC transporter signature motif; other site 762376012967 Walker B; other site 762376012968 D-loop; other site 762376012969 H-loop/switch region; other site 762376012970 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376012971 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376012972 Walker A/P-loop; other site 762376012973 ATP binding site [chemical binding]; other site 762376012974 Q-loop/lid; other site 762376012975 ABC transporter signature motif; other site 762376012976 Walker B; other site 762376012977 D-loop; other site 762376012978 H-loop/switch region; other site 762376012979 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376012980 TM-ABC transporter signature motif; other site 762376012981 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376012982 TM-ABC transporter signature motif; other site 762376012983 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376012984 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376012985 putative ligand binding site [chemical binding]; other site 762376012986 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376012987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012988 DNA-binding site [nucleotide binding]; DNA binding site 762376012989 FCD domain; Region: FCD; cl11656 762376012990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012992 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376012993 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376012994 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 762376012995 short chain dehydrogenase; Provisional; Region: PRK07677 762376012996 NAD(P) binding site [chemical binding]; other site 762376012997 substrate binding site [chemical binding]; other site 762376012998 homotetramer interface [polypeptide binding]; other site 762376012999 active site 762376013000 homodimer interface [polypeptide binding]; other site 762376013001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013003 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376013004 putative effector binding pocket; other site 762376013005 dimerization interface [polypeptide binding]; other site 762376013006 aconitate hydratase; Provisional; Region: acnA; PRK12881 762376013007 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376013008 substrate binding site [chemical binding]; other site 762376013009 ligand binding site [chemical binding]; other site 762376013010 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 762376013011 substrate binding site [chemical binding]; other site 762376013012 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376013013 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 762376013014 putative active site [active] 762376013015 metal binding site [ion binding]; metal-binding site 762376013016 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 762376013017 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 762376013018 elongation factor P; Validated; Region: PRK00529 762376013019 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762376013020 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 762376013021 RNA binding site [nucleotide binding]; other site 762376013022 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 762376013023 RNA binding site [nucleotide binding]; other site 762376013024 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 762376013025 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 762376013026 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376013027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376013028 Walker A motif; other site 762376013029 ATP binding site [chemical binding]; other site 762376013030 Walker B motif; other site 762376013031 arginine finger; other site 762376013032 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 762376013033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376013034 binding surface 762376013035 TPR motif; other site 762376013036 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762376013037 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 762376013038 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 762376013039 ATP binding site [chemical binding]; other site 762376013040 Walker A motif; other site 762376013041 hexamer interface [polypeptide binding]; other site 762376013042 Walker B motif; other site 762376013043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376013044 Response regulator receiver domain; Region: Response_reg; pfam00072 762376013045 active site 762376013046 phosphorylation site [posttranslational modification] 762376013047 intermolecular recognition site; other site 762376013048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376013049 dimerization interface [polypeptide binding]; other site 762376013050 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762376013051 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 762376013052 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376013053 SAF domain; Region: SAF; cl00555 762376013054 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 762376013055 Flp/Fap pilin component; Region: Flp_Fap; cl01585 762376013056 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 762376013057 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 762376013058 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376013059 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376013060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376013061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013062 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 762376013063 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376013064 Walker A/P-loop; other site 762376013065 ATP binding site [chemical binding]; other site 762376013066 Q-loop/lid; other site 762376013067 ABC transporter signature motif; other site 762376013068 Walker B; other site 762376013069 D-loop; other site 762376013070 H-loop/switch region; other site 762376013071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376013072 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376013073 Walker A/P-loop; other site 762376013074 ATP binding site [chemical binding]; other site 762376013075 Q-loop/lid; other site 762376013076 ABC transporter signature motif; other site 762376013077 Walker B; other site 762376013078 D-loop; other site 762376013079 H-loop/switch region; other site 762376013080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376013081 dimer interface [polypeptide binding]; other site 762376013082 conserved gate region; other site 762376013083 putative PBP binding loops; other site 762376013084 ABC-ATPase subunit interface; other site 762376013085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376013086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376013087 dimer interface [polypeptide binding]; other site 762376013088 conserved gate region; other site 762376013089 putative PBP binding loops; other site 762376013090 ABC-ATPase subunit interface; other site 762376013091 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 762376013092 Staphylococcal nuclease homologues; Region: SNc; smart00318 762376013093 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 762376013094 Catalytic site; other site 762376013095 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 762376013096 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 762376013097 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762376013098 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376013099 Protein of unknown function DUF72; Region: DUF72; cl00777 762376013100 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376013101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013102 DNA-binding site [nucleotide binding]; DNA binding site 762376013103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376013104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376013105 homodimer interface [polypeptide binding]; other site 762376013106 catalytic residue [active] 762376013107 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 762376013108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376013109 inhibitor-cofactor binding pocket; inhibition site 762376013110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376013111 catalytic residue [active] 762376013112 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376013113 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376013114 tetramerization interface [polypeptide binding]; other site 762376013115 NAD(P) binding site [chemical binding]; other site 762376013116 catalytic residues [active] 762376013117 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 762376013118 active site 762376013119 putative lithium-binding site [ion binding]; other site 762376013120 substrate binding site [chemical binding]; other site 762376013121 NAD-dependent deacetylase; Provisional; Region: PRK05333 762376013122 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 762376013123 NAD+ binding site [chemical binding]; other site 762376013124 substrate binding site [chemical binding]; other site 762376013125 Zn binding site [ion binding]; other site 762376013126 serine O-acetyltransferase; Region: cysE; TIGR01172 762376013127 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 762376013128 trimer interface [polypeptide binding]; other site 762376013129 active site 762376013130 substrate binding site [chemical binding]; other site 762376013131 CoA binding site [chemical binding]; other site 762376013132 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762376013133 UDP-glucose 4-epimerase; Region: PLN02240 762376013134 NAD binding site [chemical binding]; other site 762376013135 homodimer interface [polypeptide binding]; other site 762376013136 active site 762376013137 substrate binding site [chemical binding]; other site 762376013138 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 762376013139 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762376013140 active site 762376013141 dimer interface [polypeptide binding]; other site 762376013142 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762376013143 dimer interface [polypeptide binding]; other site 762376013144 active site 762376013145 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 762376013146 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 762376013147 active site 762376013148 substrate binding site [chemical binding]; other site 762376013149 metal binding site [ion binding]; metal-binding site 762376013150 tyrosine kinase; Provisional; Region: PRK11519 762376013151 Chain length determinant protein; Region: Wzz; cl01623 762376013152 Chain length determinant protein; Region: Wzz; cl01623 762376013153 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 762376013154 P loop; other site 762376013155 Nucleotide binding site [chemical binding]; other site 762376013156 DTAP/Switch II; other site 762376013157 Switch I; other site 762376013158 polysaccharide export protein Wza; Provisional; Region: PRK15078 762376013159 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762376013160 SLBB domain; Region: SLBB; pfam10531 762376013161 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 762376013162 Bacterial sugar transferase; Region: Bac_transf; cl00939 762376013163 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762376013164 nudix motif; other site 762376013165 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 762376013166 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 762376013167 Substrate binding site [chemical binding]; other site 762376013168 Cupin domain; Region: Cupin_2; cl09118 762376013169 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 762376013170 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 762376013171 NADP-binding site; other site 762376013172 homotetramer interface [polypeptide binding]; other site 762376013173 substrate binding site [chemical binding]; other site 762376013174 homodimer interface [polypeptide binding]; other site 762376013175 active site 762376013176 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 762376013177 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 762376013178 NADP binding site [chemical binding]; other site 762376013179 active site 762376013180 putative substrate binding site [chemical binding]; other site 762376013181 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 762376013182 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 762376013183 metal binding site [ion binding]; metal-binding site 762376013184 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 762376013185 O-Antigen ligase; Region: Wzy_C; cl04850 762376013186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376013187 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762376013188 putative ADP-binding pocket [chemical binding]; other site 762376013189 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 762376013190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376013191 putative metal binding site [ion binding]; other site 762376013192 putative acyl transferase; Provisional; Region: PRK10502 762376013193 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 762376013194 putative trimer interface [polypeptide binding]; other site 762376013195 putative active site [active] 762376013196 putative substrate binding site [chemical binding]; other site 762376013197 putative CoA binding site [chemical binding]; other site 762376013198 putative glycosyl transferase; Provisional; Region: PRK10307 762376013199 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762376013200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376013201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 762376013202 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376013203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376013204 DNA binding residues [nucleotide binding] 762376013205 dimerization interface [polypeptide binding]; other site 762376013206 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762376013207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376013208 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 762376013209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013210 active site 762376013211 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 762376013212 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 762376013213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376013214 dimer interface [polypeptide binding]; other site 762376013215 active site 762376013216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013217 fatty oxidation complex, alpha subunit FadB; Region: FadB; TIGR02437 762376013218 substrate binding site [chemical binding]; other site 762376013219 oxyanion hole (OAH) forming residues; other site 762376013220 trimer interface [polypeptide binding]; other site 762376013221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013222 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013223 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 762376013224 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 762376013225 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 762376013226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013227 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013229 substrate binding site [chemical binding]; other site 762376013230 oxyanion hole (OAH) forming residues; other site 762376013231 trimer interface [polypeptide binding]; other site 762376013232 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 762376013233 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376013234 dimer interface [polypeptide binding]; other site 762376013235 active site 762376013236 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376013237 CoenzymeA binding site [chemical binding]; other site 762376013238 subunit interaction site [polypeptide binding]; other site 762376013239 PHB binding site; other site 762376013240 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 762376013241 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 762376013242 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376013243 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376013244 Sulfatase; Region: Sulfatase; cl10460 762376013245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013247 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376013248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013249 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376013250 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013251 N-terminal plug; other site 762376013252 ligand-binding site [chemical binding]; other site 762376013253 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 762376013254 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 762376013255 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376013256 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 762376013257 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376013258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013259 DNA-binding site [nucleotide binding]; DNA binding site 762376013260 UTRA domain; Region: UTRA; cl06649 762376013261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013262 DNA-binding site [nucleotide binding]; DNA binding site 762376013263 FCD domain; Region: FCD; cl11656 762376013264 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376013265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013267 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376013268 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376013269 Coenzyme A transferase; Region: CoA_trans; cl00773 762376013270 Coenzyme A transferase; Region: CoA_trans; cl00773 762376013271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013272 substrate binding site [chemical binding]; other site 762376013273 oxyanion hole (OAH) forming residues; other site 762376013274 trimer interface [polypeptide binding]; other site 762376013275 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013280 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376013281 Cysteine dioxygenase type I; Region: CDO_I; cl02350 762376013282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376013283 non-specific DNA binding site [nucleotide binding]; other site 762376013284 salt bridge; other site 762376013285 sequence-specific DNA binding site [nucleotide binding]; other site 762376013286 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 762376013287 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 762376013288 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376013289 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 762376013290 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376013291 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 762376013292 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376013293 active site residue [active] 762376013294 aspartate kinase; Reviewed; Region: PRK06635 762376013295 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 762376013296 putative Mg ion binding site [ion binding]; other site 762376013297 putative aspartate binding site [chemical binding]; other site 762376013298 putative catalytic residues [active] 762376013299 putative nucleotide binding site [chemical binding]; other site 762376013300 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 762376013301 putative allosteric regulatory site; other site 762376013302 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 762376013303 putative allosteric regulatory residue; other site 762376013304 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762376013305 Ligand Binding Site [chemical binding]; other site 762376013306 TilS substrate binding domain; Region: TilS; pfam09179 762376013307 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376013308 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376013309 endonuclease III; Region: ENDO3c; smart00478 762376013310 minor groove reading motif; other site 762376013311 helix-hairpin-helix signature motif; other site 762376013312 substrate binding pocket [chemical binding]; other site 762376013313 active site 762376013314 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762376013315 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762376013316 active site 762376013317 HIGH motif; other site 762376013318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762376013319 KMSKS motif; other site 762376013320 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 762376013321 tRNA binding surface [nucleotide binding]; other site 762376013322 anticodon binding site; other site 762376013323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376013324 binding surface 762376013325 TPR motif; other site 762376013326 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 762376013327 substrate binding site [chemical binding]; other site 762376013328 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 762376013329 putative active site [active] 762376013330 putative metal binding site [ion binding]; other site 762376013331 Bacitracin resistance protein BacA; Region: BacA; cl00858 762376013332 Integral membrane protein TerC family; Region: TerC; cl10468 762376013333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376013334 Transporter associated domain; Region: CorC_HlyC; pfam03471 762376013335 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376013336 FMN-binding domain; Region: FMN_bind; cl01081 762376013337 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 762376013338 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 762376013339 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376013340 nitrous-oxide reductase; Validated; Region: PRK02888 762376013341 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376013342 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 762376013343 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 762376013344 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 762376013345 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376013346 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762376013347 Walker A/P-loop; other site 762376013348 ATP binding site [chemical binding]; other site 762376013349 Q-loop/lid; other site 762376013350 ABC transporter signature motif; other site 762376013351 Walker B; other site 762376013352 D-loop; other site 762376013353 H-loop/switch region; other site 762376013354 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376013355 NosL; Region: NosL; cl01769 762376013356 ApbE family; Region: ApbE; cl00643 762376013357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376013358 putative transposase OrfB; Reviewed; Region: PHA02517 762376013359 Integrase core domain; Region: rve; cl01316 762376013360 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 762376013361 active site 762376013362 dimerization interface [polypeptide binding]; other site 762376013363 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 762376013364 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762376013365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013367 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013368 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376013369 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376013370 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 762376013371 Imelysin; Region: Peptidase_M75; cl09159 762376013372 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 762376013373 Imelysin; Region: Peptidase_M75; cl09159 762376013374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013376 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376013377 putative dimerization interface [polypeptide binding]; other site 762376013378 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376013379 intersubunit interface [polypeptide binding]; other site 762376013380 active site 762376013381 Zn2+ binding site [ion binding]; other site 762376013382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013386 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376013387 putative substrate translocation pore; other site 762376013388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376013392 dimerization interface [polypeptide binding]; other site 762376013393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013394 DNA-binding site [nucleotide binding]; DNA binding site 762376013395 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 762376013396 FCD domain; Region: FCD; cl11656 762376013397 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 762376013398 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376013399 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 762376013400 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 762376013401 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376013402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376013403 putative effector binding pocket; other site 762376013404 dimerization interface [polypeptide binding]; other site 762376013405 short chain dehydrogenase; Provisional; Region: PRK07062 762376013406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013407 NAD(P) binding site [chemical binding]; other site 762376013408 active site 762376013409 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762376013410 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762376013411 putative NAD(P) binding site [chemical binding]; other site 762376013412 dimer interface [polypeptide binding]; other site 762376013413 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 762376013414 active site 762376013415 catalytic residues [active] 762376013416 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376013417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013418 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376013419 dimerization interface [polypeptide binding]; other site 762376013420 substrate binding pocket [chemical binding]; other site 762376013421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013422 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 762376013423 NAD(P) binding site [chemical binding]; other site 762376013424 active site 762376013425 fumarylacetoacetase; Region: PLN02856 762376013426 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 762376013427 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376013428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013430 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762376013431 MutS domain I; Region: MutS_I; pfam01624 762376013432 MutS domain II; Region: MutS_II; pfam05188 762376013433 MutS family domain IV; Region: MutS_IV; pfam05190 762376013434 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 762376013435 Walker A/P-loop; other site 762376013436 ATP binding site [chemical binding]; other site 762376013437 Q-loop/lid; other site 762376013438 ABC transporter signature motif; other site 762376013439 Walker B; other site 762376013440 D-loop; other site 762376013441 H-loop/switch region; other site 762376013442 Cupin superfamily protein; Region: Cupin_4; pfam08007 762376013443 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 762376013444 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 762376013445 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376013446 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762376013447 dimer interface [polypeptide binding]; other site 762376013448 active site 762376013449 catalytic residue [active] 762376013450 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 762376013451 active site 762376013452 putative substrate binding region [chemical binding]; other site 762376013453 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 762376013454 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 762376013455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013456 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376013457 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376013458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376013459 Coenzyme A binding pocket [chemical binding]; other site 762376013460 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 762376013461 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762376013462 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762376013463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013465 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376013466 putative dimerization interface [polypeptide binding]; other site 762376013467 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376013468 active site 762376013469 catalytic residues [active] 762376013470 metal binding site [ion binding]; metal-binding site 762376013471 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376013472 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376013473 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376013474 DctM-like transporters; Region: DctM; pfam06808 762376013475 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376013476 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013479 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 762376013480 Baseplate J-like protein; Region: Baseplate_J; cl01294 762376013481 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 762376013482 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 762376013483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 762376013484 Catalytic site [active] 762376013485 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 762376013486 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 762376013487 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 762376013488 putative active site [active] 762376013489 catalytic site [active] 762376013490 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 762376013491 putative active site [active] 762376013492 catalytic site [active] 762376013493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013495 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376013496 putative dimerization interface [polypeptide binding]; other site 762376013497 enoyl-CoA hydratase; Provisional; Region: PRK06143 762376013498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013499 substrate binding site [chemical binding]; other site 762376013500 oxyanion hole (OAH) forming residues; other site 762376013501 trimer interface [polypeptide binding]; other site 762376013502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013504 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013507 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376013508 CoenzymeA binding site [chemical binding]; other site 762376013509 subunit interaction site [polypeptide binding]; other site 762376013510 PHB binding site; other site 762376013511 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013512 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376013513 substrate binding site [chemical binding]; other site 762376013514 oxyanion hole (OAH) forming residues; other site 762376013515 trimer interface [polypeptide binding]; other site 762376013516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013517 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013518 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013520 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376013521 active site 762376013522 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376013523 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376013524 active site 762376013525 Coenzyme A transferase; Region: CoA_trans; cl00773 762376013526 Coenzyme A transferase; Region: CoA_trans; cl00773 762376013527 thiolase; Provisional; Region: PRK06158 762376013528 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376013529 active site 762376013530 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376013531 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376013532 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376013533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376013536 EamA-like transporter family; Region: EamA; cl01037 762376013537 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 762376013538 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376013539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013540 DNA-binding site [nucleotide binding]; DNA binding site 762376013541 FCD domain; Region: FCD; cl11656 762376013542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013544 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376013545 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376013546 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 762376013547 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376013548 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376013549 Ligand binding site [chemical binding]; other site 762376013550 Putative Catalytic site [active] 762376013551 DXD motif; other site 762376013552 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 762376013553 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 762376013554 Outer membrane efflux protein; Region: OEP; pfam02321 762376013555 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376013556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376013557 active site 762376013558 phosphorylation site [posttranslational modification] 762376013559 intermolecular recognition site; other site 762376013560 dimerization interface [polypeptide binding]; other site 762376013561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376013562 DNA binding site [nucleotide binding] 762376013563 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376013564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376013565 dimer interface [polypeptide binding]; other site 762376013566 phosphorylation site [posttranslational modification] 762376013567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376013568 ATP binding site [chemical binding]; other site 762376013569 Mg2+ binding site [ion binding]; other site 762376013570 G-X-G motif; other site 762376013571 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376013572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013574 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 762376013575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013576 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 762376013577 substrate binding pocket [chemical binding]; other site 762376013578 dimerization interface [polypeptide binding]; other site 762376013579 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 762376013580 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376013581 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 762376013582 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762376013583 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376013584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376013585 PYR/PP interface [polypeptide binding]; other site 762376013586 dimer interface [polypeptide binding]; other site 762376013587 TPP binding site [chemical binding]; other site 762376013588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376013589 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376013590 TPP-binding site [chemical binding]; other site 762376013591 NADH dehydrogenase subunit G; Validated; Region: PRK08493 762376013592 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 762376013593 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 762376013594 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376013595 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376013596 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376013597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013598 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013599 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376013600 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376013601 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376013602 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376013603 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 762376013604 active site 762376013605 dimer interface [polypeptide binding]; other site 762376013606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013609 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376013610 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376013611 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 762376013612 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 762376013613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376013614 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376013615 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376013616 OsmC-like protein; Region: OsmC; cl00767 762376013617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013619 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376013620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013621 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 762376013622 Cysteine-rich domain; Region: CCG; pfam02754 762376013623 FAD binding domain; Region: FAD_binding_4; pfam01565 762376013624 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 762376013625 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 762376013626 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 762376013627 NAD(P) binding site [chemical binding]; other site 762376013628 active site 762376013629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013631 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376013632 Strictosidine synthase; Region: Str_synth; pfam03088 762376013633 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376013634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013636 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376013637 putative dimerization interface [polypeptide binding]; other site 762376013638 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 762376013639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 762376013640 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762376013641 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376013642 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762376013643 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 762376013644 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376013645 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376013646 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762376013647 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762376013648 YcfA-like protein; Region: YcfA; cl00752 762376013649 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 762376013650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376013651 Cupin domain; Region: Cupin_2; cl09118 762376013652 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376013653 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376013654 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376013655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376013656 dimer interface [polypeptide binding]; other site 762376013657 conserved gate region; other site 762376013658 putative PBP binding loops; other site 762376013659 ABC-ATPase subunit interface; other site 762376013660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376013661 dimer interface [polypeptide binding]; other site 762376013662 conserved gate region; other site 762376013663 putative PBP binding loops; other site 762376013664 ABC-ATPase subunit interface; other site 762376013665 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376013666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376013667 substrate binding pocket [chemical binding]; other site 762376013668 membrane-bound complex binding site; other site 762376013669 hinge residues; other site 762376013670 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376013671 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376013672 Walker A/P-loop; other site 762376013673 ATP binding site [chemical binding]; other site 762376013674 Q-loop/lid; other site 762376013675 ABC transporter signature motif; other site 762376013676 Walker B; other site 762376013677 D-loop; other site 762376013678 H-loop/switch region; other site 762376013679 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376013680 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 762376013681 tetrameric interface [polypeptide binding]; other site 762376013682 NAD binding site [chemical binding]; other site 762376013683 catalytic residues [active] 762376013684 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cl00248 762376013685 substrate binding site [chemical binding]; other site 762376013686 dimerization interface [polypeptide binding]; other site 762376013687 active site 762376013688 calcium binding site [ion binding]; other site 762376013689 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 762376013690 dimer interface [polypeptide binding]; other site 762376013691 pyridoxal binding site [chemical binding]; other site 762376013692 ATP binding site [chemical binding]; other site 762376013693 Cupin domain; Region: Cupin_2; cl09118 762376013694 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 762376013695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376013696 non-specific DNA binding site [nucleotide binding]; other site 762376013697 salt bridge; other site 762376013698 sequence-specific DNA binding site [nucleotide binding]; other site 762376013699 Cupin domain; Region: Cupin_2; cl09118 762376013700 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376013701 intersubunit interface [polypeptide binding]; other site 762376013702 active site 762376013703 Zn2+ binding site [ion binding]; other site 762376013704 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376013705 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376013706 GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179 762376013707 putative N-terminal domain interface [polypeptide binding]; other site 762376013708 putative dimer interface [polypeptide binding]; other site 762376013709 putative substrate binding pocket (H-site) [chemical binding]; other site 762376013710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376013713 dimerization interface [polypeptide binding]; other site 762376013714 putative DNA binding site [nucleotide binding]; other site 762376013715 putative Zn2+ binding site [ion binding]; other site 762376013716 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 762376013717 putative metal binding site [ion binding]; other site 762376013718 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376013719 Active site [active] 762376013720 Membrane transport protein; Region: Mem_trans; cl09117 762376013721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013722 putative substrate translocation pore; other site 762376013723 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376013724 catalytic residues [active] 762376013725 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376013726 Nuclease-related domain; Region: NERD; pfam08378 762376013727 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 762376013728 SEC-C motif; Region: SEC-C; cl12132 762376013729 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376013730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376013731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376013732 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376013733 FecR protein; Region: FecR; pfam04773 762376013734 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376013735 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013736 N-terminal plug; other site 762376013737 ligand-binding site [chemical binding]; other site 762376013738 RNA polymerase sigma factor; Reviewed; Region: PRK12523 762376013739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376013740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376013741 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376013742 FecR protein; Region: FecR; pfam04773 762376013743 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376013744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013745 N-terminal plug; other site 762376013746 ligand-binding site [chemical binding]; other site 762376013747 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376013748 conserved cys residue [active] 762376013749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376013750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376013751 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376013752 autotransport protein MisL; Provisional; Region: PRK15313 762376013753 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43...; Region: PL2_Passenger_AT; cd01344 762376013754 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376013755 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376013756 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 762376013757 active site/substrate binding site [active] 762376013758 tetramer interface [polypeptide binding]; other site 762376013759 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376013760 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376013761 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376013762 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013763 N-terminal plug; other site 762376013764 ligand-binding site [chemical binding]; other site 762376013765 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376013766 FecR protein; Region: FecR; pfam04773 762376013767 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376013768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376013769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376013770 DNA binding residues [nucleotide binding] 762376013771 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013772 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 762376013773 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376013774 dimer interface [polypeptide binding]; other site 762376013775 active site 762376013776 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; cl14878 762376013777 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376013778 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013779 active site 762376013780 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376013781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013782 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376013783 dimerization interface [polypeptide binding]; other site 762376013784 substrate binding pocket [chemical binding]; other site 762376013785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013789 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376013790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376013791 substrate binding site [chemical binding]; other site 762376013792 oxyanion hole (OAH) forming residues; other site 762376013793 trimer interface [polypeptide binding]; other site 762376013794 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013800 dimerization interface [polypeptide binding]; other site 762376013801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013802 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376013803 NAD(P) binding site [chemical binding]; other site 762376013804 active site 762376013805 enoyl-CoA hydratase; Region: PLN02864 762376013806 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376013807 dimer interaction site [polypeptide binding]; other site 762376013808 substrate-binding tunnel; other site 762376013809 active site 762376013810 catalytic site [active] 762376013811 substrate binding site [chemical binding]; other site 762376013812 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 762376013813 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 762376013814 dimer interface [polypeptide binding]; other site 762376013815 active site 762376013816 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376013817 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376013818 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 762376013819 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376013820 active site 762376013821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376013822 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013823 active site 762376013824 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013827 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 762376013828 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 762376013829 active site residues [active] 762376013830 dimer interface [polypeptide binding]; other site 762376013831 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 762376013832 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762376013833 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 762376013834 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376013835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376013836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013837 active site 762376013838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376013839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013840 NAD(P) binding site [chemical binding]; other site 762376013841 active site 762376013842 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376013843 active site 762376013844 catalytic site [active] 762376013845 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376013846 active site 762376013847 catalytic site [active] 762376013848 lipid-transfer protein; Provisional; Region: PRK08256 762376013849 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376013850 active site 762376013851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 762376013852 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376013853 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376013854 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376013855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013856 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013859 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376013860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013861 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376013862 dimerization interface [polypeptide binding]; other site 762376013863 substrate binding pocket [chemical binding]; other site 762376013864 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376013865 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376013866 active site 2 [active] 762376013867 active site 1 [active] 762376013868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013870 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376013871 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376013872 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 762376013873 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 762376013874 Walker A/P-loop; other site 762376013875 ATP binding site [chemical binding]; other site 762376013876 Q-loop/lid; other site 762376013877 ABC transporter signature motif; other site 762376013878 Walker B; other site 762376013879 D-loop; other site 762376013880 H-loop/switch region; other site 762376013881 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 762376013882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376013883 dimer interface [polypeptide binding]; other site 762376013884 conserved gate region; other site 762376013885 putative PBP binding loops; other site 762376013886 ABC-ATPase subunit interface; other site 762376013887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013888 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762376013889 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 762376013890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376013891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013892 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 762376013893 putative substrate translocation pore; other site 762376013894 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 762376013895 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 762376013896 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376013897 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 762376013898 putative ligand binding site [chemical binding]; other site 762376013899 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376013900 TM-ABC transporter signature motif; other site 762376013901 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376013902 TM-ABC transporter signature motif; other site 762376013903 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376013904 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376013905 Walker A/P-loop; other site 762376013906 ATP binding site [chemical binding]; other site 762376013907 Q-loop/lid; other site 762376013908 ABC transporter signature motif; other site 762376013909 Walker B; other site 762376013910 D-loop; other site 762376013911 H-loop/switch region; other site 762376013912 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762376013913 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376013914 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376013915 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376013916 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376013917 tetramer interface [polypeptide binding]; other site 762376013918 active site 762376013919 Mg2+/Mn2+ binding site [ion binding]; other site 762376013920 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 762376013921 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762376013922 Beta-lactamase; Region: Beta-lactamase; cl01009 762376013923 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 762376013924 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257 762376013925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376013927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013928 putative substrate translocation pore; other site 762376013929 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762376013930 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762376013931 HIGH motif; other site 762376013932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376013933 active site 762376013934 KMSKS motif; other site 762376013935 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762376013936 tRNA binding surface [nucleotide binding]; other site 762376013937 Lipopolysaccharide-assembly; Region: LptE; cl01125 762376013938 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 762376013939 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762376013940 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 762376013941 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 762376013942 putative catalytic cysteine [active] 762376013943 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376013944 amidase; Provisional; Region: PRK07487 762376013945 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376013946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013949 dimerization interface [polypeptide binding]; other site 762376013950 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376013951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013952 putative substrate translocation pore; other site 762376013953 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 762376013954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376013955 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376013957 SEC-C motif; Region: SEC-C; cl12132 762376013958 hypothetical protein; Provisional; Region: PRK04233 762376013959 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376013960 intersubunit interface [polypeptide binding]; other site 762376013961 active site 762376013962 Zn2+ binding site [ion binding]; other site 762376013963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013964 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376013965 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376013966 dimerization interface [polypeptide binding]; other site 762376013967 substrate binding pocket [chemical binding]; other site 762376013968 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 762376013969 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 762376013970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376013972 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 762376013973 putative dimerization interface [polypeptide binding]; other site 762376013974 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 762376013975 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 762376013976 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376013977 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 762376013978 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 762376013979 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762376013980 active site 762376013981 catalytic site [active] 762376013982 substrate binding site [chemical binding]; other site 762376013983 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 762376013984 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 762376013985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376013986 putative active site [active] 762376013987 heme pocket [chemical binding]; other site 762376013988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376013989 putative active site [active] 762376013990 heme pocket [chemical binding]; other site 762376013991 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376013992 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 762376013993 glutathione s-transferase; Provisional; Region: PTZ00057 762376013994 GSH binding site (G-site) [chemical binding]; other site 762376013995 C-terminal domain interface [polypeptide binding]; other site 762376013996 dimer interface [polypeptide binding]; other site 762376013997 GST_C family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi, and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_C_Sigma_like; cd03192 762376013998 dimer interface [polypeptide binding]; other site 762376013999 N-terminal domain interface [polypeptide binding]; other site 762376014000 substrate binding pocket (H-site) [chemical binding]; other site 762376014001 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376014002 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 762376014003 conserved cys residue [active] 762376014004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376014005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014006 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376014007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376014008 Walker A/P-loop; other site 762376014009 ATP binding site [chemical binding]; other site 762376014010 Q-loop/lid; other site 762376014011 ABC transporter signature motif; other site 762376014012 Walker B; other site 762376014013 D-loop; other site 762376014014 H-loop/switch region; other site 762376014015 TOBE domain; Region: TOBE_2; cl01440 762376014016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014017 dimer interface [polypeptide binding]; other site 762376014018 conserved gate region; other site 762376014019 putative PBP binding loops; other site 762376014020 ABC-ATPase subunit interface; other site 762376014021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014022 dimer interface [polypeptide binding]; other site 762376014023 conserved gate region; other site 762376014024 putative PBP binding loops; other site 762376014025 ABC-ATPase subunit interface; other site 762376014026 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 762376014027 Proline racemase; Region: Pro_racemase; pfam05544 762376014028 choline dehydrogenase; Validated; Region: PRK02106 762376014029 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376014030 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 762376014031 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376014032 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376014033 shikimate binding site; other site 762376014034 NAD(P) binding site [chemical binding]; other site 762376014035 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 762376014036 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376014037 PYR/PP interface [polypeptide binding]; other site 762376014038 dimer interface [polypeptide binding]; other site 762376014039 TPP binding site [chemical binding]; other site 762376014040 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376014041 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376014042 TPP-binding site [chemical binding]; other site 762376014043 dimer interface [polypeptide binding]; other site 762376014044 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376014045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014046 DNA-binding site [nucleotide binding]; DNA binding site 762376014047 FCD domain; Region: FCD; cl11656 762376014048 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 762376014049 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 762376014050 dimer interface [polypeptide binding]; other site 762376014051 active site 762376014052 metal binding site [ion binding]; metal-binding site 762376014053 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 762376014054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014055 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 762376014056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376014057 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376014058 classical (c) SDRs; Region: SDR_c; cd05233 762376014059 NAD(P) binding site [chemical binding]; other site 762376014060 active site 762376014061 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376014062 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376014063 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376014064 TM-ABC transporter signature motif; other site 762376014065 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376014066 TM-ABC transporter signature motif; other site 762376014067 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376014068 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376014069 Walker A/P-loop; other site 762376014070 ATP binding site [chemical binding]; other site 762376014071 Q-loop/lid; other site 762376014072 ABC transporter signature motif; other site 762376014073 Walker B; other site 762376014074 D-loop; other site 762376014075 H-loop/switch region; other site 762376014076 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376014077 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376014078 Walker A/P-loop; other site 762376014079 ATP binding site [chemical binding]; other site 762376014080 Q-loop/lid; other site 762376014081 ABC transporter signature motif; other site 762376014082 Walker B; other site 762376014083 D-loop; other site 762376014084 H-loop/switch region; other site 762376014085 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376014086 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376014087 NAD(P) binding site [chemical binding]; other site 762376014088 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376014089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014090 NAD(P) binding site [chemical binding]; other site 762376014091 active site 762376014092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376014093 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376014094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376014095 active site 762376014096 catalytic tetrad [active] 762376014097 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 762376014098 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376014099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376014100 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376014101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762376014102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376014103 catalytic residue [active] 762376014104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014105 dimer interface [polypeptide binding]; other site 762376014106 conserved gate region; other site 762376014107 putative PBP binding loops; other site 762376014108 ABC-ATPase subunit interface; other site 762376014109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014110 dimer interface [polypeptide binding]; other site 762376014111 ABC-ATPase subunit interface; other site 762376014112 putative PBP binding loops; other site 762376014113 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376014114 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376014115 Walker A/P-loop; other site 762376014116 ATP binding site [chemical binding]; other site 762376014117 Q-loop/lid; other site 762376014118 ABC transporter signature motif; other site 762376014119 Walker B; other site 762376014120 D-loop; other site 762376014121 H-loop/switch region; other site 762376014122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376014123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376014124 substrate binding pocket [chemical binding]; other site 762376014125 membrane-bound complex binding site; other site 762376014126 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 762376014127 homotrimer interaction site [polypeptide binding]; other site 762376014128 putative active site [active] 762376014129 Predicted deacylase [General function prediction only]; Region: COG3608 762376014130 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 762376014131 active site 762376014132 Zn-binding site [ion binding]; other site 762376014133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376014134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376014135 DNA binding site [nucleotide binding] 762376014136 domain linker motif; other site 762376014137 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 762376014138 putative dimerization interface [polypeptide binding]; other site 762376014139 putative ligand binding site [chemical binding]; other site 762376014140 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376014141 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376014142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014143 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376014144 putative effector binding pocket; other site 762376014145 putative dimerization interface [polypeptide binding]; other site 762376014146 Isochorismatase family; Region: Isochorismatase; pfam00857 762376014147 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 762376014148 catalytic triad [active] 762376014149 dimer interface [polypeptide binding]; other site 762376014150 conserved cis-peptide bond; other site 762376014151 Isochorismatase family; Region: Isochorismatase; pfam00857 762376014152 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 762376014153 catalytic triad [active] 762376014154 dimer interface [polypeptide binding]; other site 762376014155 conserved cis-peptide bond; other site 762376014156 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 762376014157 Protein of unknown function (DUF465); Region: DUF465; cl01070 762376014158 LysE type translocator; Region: LysE; cl00565 762376014159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376014160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376014161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376014162 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 762376014163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376014164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376014165 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376014166 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376014167 Walker A/P-loop; other site 762376014168 ATP binding site [chemical binding]; other site 762376014169 Q-loop/lid; other site 762376014170 ABC transporter signature motif; other site 762376014171 Walker B; other site 762376014172 D-loop; other site 762376014173 H-loop/switch region; other site 762376014174 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376014175 TM-ABC transporter signature motif; other site 762376014176 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376014177 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376014178 Walker A/P-loop; other site 762376014179 ATP binding site [chemical binding]; other site 762376014180 Q-loop/lid; other site 762376014181 ABC transporter signature motif; other site 762376014182 Walker B; other site 762376014183 D-loop; other site 762376014184 H-loop/switch region; other site 762376014185 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376014186 TM-ABC transporter signature motif; other site 762376014187 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376014188 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376014189 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376014190 acyl-CoA synthetase; Validated; Region: PRK06145 762376014191 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376014192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014193 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376014194 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376014195 active site 762376014196 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762376014197 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376014198 E3 interaction surface; other site 762376014199 lipoyl attachment site [posttranslational modification]; other site 762376014200 e3 binding domain; Region: E3_binding; pfam02817 762376014201 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762376014202 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376014203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014204 substrate binding site [chemical binding]; other site 762376014205 oxyanion hole (OAH) forming residues; other site 762376014206 trimer interface [polypeptide binding]; other site 762376014207 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376014208 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376014209 alpha subunit interface [polypeptide binding]; other site 762376014210 TPP binding site [chemical binding]; other site 762376014211 heterodimer interface [polypeptide binding]; other site 762376014212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376014213 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 762376014214 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376014215 tetramer interface [polypeptide binding]; other site 762376014216 TPP-binding site [chemical binding]; other site 762376014217 heterodimer interface [polypeptide binding]; other site 762376014218 phosphorylation loop region [posttranslational modification] 762376014219 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014221 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014222 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376014223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014224 substrate binding site [chemical binding]; other site 762376014225 oxyanion hole (OAH) forming residues; other site 762376014226 trimer interface [polypeptide binding]; other site 762376014227 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 762376014228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014229 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 762376014230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014234 active site 762376014235 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376014236 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014237 substrate binding site [chemical binding]; other site 762376014238 oxyanion hole (OAH) forming residues; other site 762376014239 trimer interface [polypeptide binding]; other site 762376014240 thiolase; Provisional; Region: PRK06158 762376014241 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376014242 active site 762376014243 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376014244 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376014245 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376014246 active site 762376014247 catalytic site [active] 762376014248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014250 active site 762376014251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014253 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376014254 putative substrate binding pocket [chemical binding]; other site 762376014255 dimerization interface [polypeptide binding]; other site 762376014256 LamB/YcsF family; Region: LamB_YcsF; cl00664 762376014257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376014258 carboxyltransferase (CT) interaction site; other site 762376014259 biotinylation site [posttranslational modification]; other site 762376014260 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 762376014261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376014262 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376014264 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 762376014265 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 762376014266 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 762376014267 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 762376014268 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762376014269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376014270 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376014271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376014272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376014273 fec operon regulator FecR; Reviewed; Region: PRK09774 762376014274 FecR protein; Region: FecR; pfam04773 762376014275 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376014276 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376014277 N-terminal plug; other site 762376014278 ligand-binding site [chemical binding]; other site 762376014279 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376014280 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 762376014281 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762376014282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376014283 nucleotide binding region [chemical binding]; other site 762376014284 ATP-binding site [chemical binding]; other site 762376014285 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762376014286 active site 762376014287 putative substrate binding region [chemical binding]; other site 762376014288 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376014289 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 762376014290 Outer membrane efflux protein; Region: OEP; pfam02321 762376014291 Outer membrane efflux protein; Region: OEP; pfam02321 762376014292 SapC; Region: SapC; pfam07277 762376014293 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 762376014294 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376014295 active site 762376014296 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376014297 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376014298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014300 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376014301 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376014302 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376014303 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376014304 ligand binding site [chemical binding]; other site 762376014305 flexible hinge region; other site 762376014306 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 762376014307 active site 762376014308 oxalacetate binding site [chemical binding]; other site 762376014309 citrylCoA binding site [chemical binding]; other site 762376014310 coenzyme A binding site [chemical binding]; other site 762376014311 catalytic triad [active] 762376014312 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376014313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014314 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376014316 active site 2 [active] 762376014317 active site 1 [active] 762376014318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014320 active site 762376014321 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376014322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014323 NAD(P) binding site [chemical binding]; other site 762376014324 active site 762376014325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014327 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376014328 active site 762376014329 catalytic site [active] 762376014330 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376014331 active site 762376014332 catalytic site [active] 762376014333 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376014334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014335 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014338 active site 762376014339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014341 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376014342 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376014343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014344 substrate binding site [chemical binding]; other site 762376014345 oxyanion hole (OAH) forming residues; other site 762376014346 trimer interface [polypeptide binding]; other site 762376014347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014348 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014349 enoyl-CoA hydratase; Provisional; Region: PRK06495 762376014350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014351 substrate binding site [chemical binding]; other site 762376014352 oxyanion hole (OAH) forming residues; other site 762376014353 trimer interface [polypeptide binding]; other site 762376014354 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 762376014355 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376014356 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376014357 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376014358 Ligand binding site [chemical binding]; other site 762376014359 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376014360 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014361 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014362 active site 762376014363 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 762376014364 putative active site [active] 762376014365 putative catalytic site [active] 762376014366 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376014367 active site 2 [active] 762376014368 active site 1 [active] 762376014369 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376014370 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376014371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014372 DNA-binding site [nucleotide binding]; DNA binding site 762376014373 UTRA domain; Region: UTRA; cl06649 762376014374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014375 putative substrate translocation pore; other site 762376014376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014378 classical (c) SDRs; Region: SDR_c; cd05233 762376014379 NAD(P) binding site [chemical binding]; other site 762376014380 active site 762376014381 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376014382 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 762376014383 NAD(P) binding site [chemical binding]; other site 762376014384 catalytic residues [active] 762376014385 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376014386 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 762376014387 FMN-binding pocket [chemical binding]; other site 762376014388 flavin binding motif; other site 762376014389 phosphate binding motif [ion binding]; other site 762376014390 beta-alpha-beta structure motif; other site 762376014391 NAD binding pocket [chemical binding]; other site 762376014392 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376014393 catalytic loop [active] 762376014394 iron binding site [ion binding]; other site 762376014395 Cytochrome P450; Region: p450; cl12078 762376014396 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 762376014397 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 762376014398 Walker A/P-loop; other site 762376014399 ATP binding site [chemical binding]; other site 762376014400 Q-loop/lid; other site 762376014401 ABC transporter signature motif; other site 762376014402 Walker B; other site 762376014403 D-loop; other site 762376014404 H-loop/switch region; other site 762376014405 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 762376014406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014407 dimer interface [polypeptide binding]; other site 762376014408 conserved gate region; other site 762376014409 putative PBP binding loops; other site 762376014410 ABC-ATPase subunit interface; other site 762376014411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014412 dimer interface [polypeptide binding]; other site 762376014413 conserved gate region; other site 762376014414 putative PBP binding loops; other site 762376014415 ABC-ATPase subunit interface; other site 762376014416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014417 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 762376014418 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376014419 putative active site [active] 762376014420 catalytic site [active] 762376014421 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762376014422 putative domain interface [polypeptide binding]; other site 762376014423 putative active site [active] 762376014424 catalytic site [active] 762376014425 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 762376014426 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762376014427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376014428 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 762376014429 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 762376014430 active site 762376014431 substrate binding site [chemical binding]; other site 762376014432 metal binding site [ion binding]; metal-binding site 762376014433 dihydropteroate synthase; Region: DHPS; TIGR01496 762376014434 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 762376014435 substrate binding pocket [chemical binding]; other site 762376014436 dimer interface [polypeptide binding]; other site 762376014437 inhibitor binding site; inhibition site 762376014438 FtsH Extracellular; Region: FtsH_ext; pfam06480 762376014439 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 762376014440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376014441 Walker A motif; other site 762376014442 ATP binding site [chemical binding]; other site 762376014443 Walker B motif; other site 762376014444 arginine finger; other site 762376014445 Peptidase family M41; Region: Peptidase_M41; pfam01434 762376014446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376014447 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 762376014448 Mig-14; Region: Mig-14; pfam07395 762376014449 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762376014450 domain; Region: GreA_GreB_N; pfam03449 762376014451 C-term; Region: GreA_GreB; pfam01272 762376014452 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376014453 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376014454 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 762376014455 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376014456 Permease family; Region: Xan_ur_permease; pfam00860 762376014457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014459 dimer interface [polypeptide binding]; other site 762376014460 conserved gate region; other site 762376014461 putative PBP binding loops; other site 762376014462 ABC-ATPase subunit interface; other site 762376014463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014464 dimer interface [polypeptide binding]; other site 762376014465 conserved gate region; other site 762376014466 putative PBP binding loops; other site 762376014467 ABC-ATPase subunit interface; other site 762376014468 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376014469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376014470 Walker A/P-loop; other site 762376014471 ATP binding site [chemical binding]; other site 762376014472 Q-loop/lid; other site 762376014473 ABC transporter signature motif; other site 762376014474 Walker B; other site 762376014475 D-loop; other site 762376014476 H-loop/switch region; other site 762376014477 TOBE domain; Region: TOBE_2; cl01440 762376014478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376014480 dimerization interface [polypeptide binding]; other site 762376014481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376014482 catalytic core [active] 762376014483 short chain dehydrogenase; Provisional; Region: PRK08251 762376014484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014485 NAD(P) binding site [chemical binding]; other site 762376014486 active site 762376014487 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762376014488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376014489 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014490 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762376014491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376014492 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014493 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762376014494 IMP binding site; other site 762376014495 dimer interface [polypeptide binding]; other site 762376014496 interdomain contacts; other site 762376014497 partial ornithine binding site; other site 762376014498 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762376014499 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 762376014500 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762376014501 catalytic site [active] 762376014502 subunit interface [polypeptide binding]; other site 762376014503 transaldolase-like protein; Provisional; Region: PTZ00411 762376014504 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 762376014505 active site 762376014506 dimer interface [polypeptide binding]; other site 762376014507 catalytic residue [active] 762376014508 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376014509 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376014510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014511 dimer interface [polypeptide binding]; other site 762376014512 conserved gate region; other site 762376014513 putative PBP binding loops; other site 762376014514 ABC-ATPase subunit interface; other site 762376014515 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376014516 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376014517 Walker A/P-loop; other site 762376014518 ATP binding site [chemical binding]; other site 762376014519 Q-loop/lid; other site 762376014520 ABC transporter signature motif; other site 762376014521 Walker B; other site 762376014522 D-loop; other site 762376014523 H-loop/switch region; other site 762376014524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014525 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376014526 recombination protein RecR; Reviewed; Region: recR; PRK00076 762376014527 RecR protein; Region: RecR; pfam02132 762376014528 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762376014529 putative active site [active] 762376014530 putative metal-binding site [ion binding]; other site 762376014531 tetramer interface [polypeptide binding]; other site 762376014532 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 762376014533 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 762376014534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376014535 Walker A motif; other site 762376014536 ATP binding site [chemical binding]; other site 762376014537 Walker B motif; other site 762376014538 arginine finger; other site 762376014539 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762376014540 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 762376014541 Cupin domain; Region: Cupin_2; cl09118 762376014542 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376014543 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376014544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376014545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014546 ABC-ATPase subunit interface; other site 762376014547 putative PBP binding loops; other site 762376014548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014549 dimer interface [polypeptide binding]; other site 762376014550 conserved gate region; other site 762376014551 putative PBP binding loops; other site 762376014552 ABC-ATPase subunit interface; other site 762376014553 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376014554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014555 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376014556 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 762376014557 Walker A/P-loop; other site 762376014558 ATP binding site [chemical binding]; other site 762376014559 Q-loop/lid; other site 762376014560 ABC transporter signature motif; other site 762376014561 Walker B; other site 762376014562 D-loop; other site 762376014563 H-loop/switch region; other site 762376014564 TOBE domain; Region: TOBE_2; cl01440 762376014565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014567 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014568 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 762376014569 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376014570 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 762376014571 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376014572 probable DNA repair protein; Region: TIGR03623 762376014573 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 762376014574 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762376014575 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 762376014576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014577 putative substrate translocation pore; other site 762376014578 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 762376014579 Beta-lactamase; Region: Beta-lactamase; cl01009 762376014580 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 762376014581 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376014582 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762376014583 NAD binding site [chemical binding]; other site 762376014584 substrate binding site [chemical binding]; other site 762376014585 catalytic Zn binding site [ion binding]; other site 762376014586 tetramer interface [polypeptide binding]; other site 762376014587 structural Zn binding site [ion binding]; other site 762376014588 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 762376014589 conserved cys residue [active] 762376014590 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 762376014591 putative deacylase active site [active] 762376014592 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 762376014593 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376014594 DNA binding site [nucleotide binding] 762376014595 Int/Topo IB signature motif; other site 762376014596 active site 762376014597 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376014598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014600 dimerization interface [polypeptide binding]; other site 762376014601 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376014602 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376014603 PYR/PP interface [polypeptide binding]; other site 762376014604 dimer interface [polypeptide binding]; other site 762376014605 TPP binding site [chemical binding]; other site 762376014606 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376014607 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 762376014608 TPP-binding site [chemical binding]; other site 762376014609 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 762376014610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014611 FAD binding site [chemical binding]; other site 762376014612 substrate binding pocket [chemical binding]; other site 762376014613 catalytic base [active] 762376014614 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376014615 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376014616 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 762376014617 putative active site [active] 762376014618 putative catalytic site [active] 762376014619 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 762376014620 4Fe-4S binding domain; Region: Fer4; cl02805 762376014621 4Fe-4S binding domain; Region: Fer4; cl02805 762376014622 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 762376014623 dimerization interface [polypeptide binding]; other site 762376014624 FAD binding pocket [chemical binding]; other site 762376014625 FAD binding motif [chemical binding]; other site 762376014626 catalytic residues [active] 762376014627 NAD binding pocket [chemical binding]; other site 762376014628 phosphate binding motif [ion binding]; other site 762376014629 beta-alpha-beta structure motif; other site 762376014630 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 762376014631 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 762376014632 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014633 substrate binding site [chemical binding]; other site 762376014634 oxyanion hole (OAH) forming residues; other site 762376014635 trimer interface [polypeptide binding]; other site 762376014636 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 762376014637 oxyanion hole (OAH) forming residues; other site 762376014638 trimer interface [polypeptide binding]; other site 762376014639 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 762376014640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376014641 non-specific DNA binding site [nucleotide binding]; other site 762376014642 salt bridge; other site 762376014643 sequence-specific DNA binding site [nucleotide binding]; other site 762376014644 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 762376014645 ADP binding site [chemical binding]; other site 762376014646 magnesium binding site [ion binding]; other site 762376014647 putative shikimate binding site; other site 762376014648 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 762376014649 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376014650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376014651 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376014652 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 762376014653 putative ligand binding site [chemical binding]; other site 762376014654 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376014655 TM-ABC transporter signature motif; other site 762376014656 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376014657 TM-ABC transporter signature motif; other site 762376014658 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376014659 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376014660 Walker A/P-loop; other site 762376014661 ATP binding site [chemical binding]; other site 762376014662 Q-loop/lid; other site 762376014663 ABC transporter signature motif; other site 762376014664 Walker B; other site 762376014665 D-loop; other site 762376014666 H-loop/switch region; other site 762376014667 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376014668 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376014669 Walker A/P-loop; other site 762376014670 ATP binding site [chemical binding]; other site 762376014671 Q-loop/lid; other site 762376014672 ABC transporter signature motif; other site 762376014673 Walker B; other site 762376014674 D-loop; other site 762376014675 H-loop/switch region; other site 762376014676 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376014677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376014678 Walker A/P-loop; other site 762376014679 ATP binding site [chemical binding]; other site 762376014680 Q-loop/lid; other site 762376014681 ABC transporter signature motif; other site 762376014682 Walker B; other site 762376014683 D-loop; other site 762376014684 H-loop/switch region; other site 762376014685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014686 dimer interface [polypeptide binding]; other site 762376014687 conserved gate region; other site 762376014688 putative PBP binding loops; other site 762376014689 ABC-ATPase subunit interface; other site 762376014690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014691 dimer interface [polypeptide binding]; other site 762376014692 conserved gate region; other site 762376014693 putative PBP binding loops; other site 762376014694 ABC-ATPase subunit interface; other site 762376014695 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376014696 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376014697 active site 762376014698 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376014699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014703 dimerization interface [polypeptide binding]; other site 762376014704 hypothetical protein; Validated; Region: PRK07586 762376014705 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376014706 PYR/PP interface [polypeptide binding]; other site 762376014707 dimer interface [polypeptide binding]; other site 762376014708 TPP binding site [chemical binding]; other site 762376014709 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 762376014710 TPP-binding site [chemical binding]; other site 762376014711 dimer interface [polypeptide binding]; other site 762376014712 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376014713 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376014714 Walker A/P-loop; other site 762376014715 ATP binding site [chemical binding]; other site 762376014716 Q-loop/lid; other site 762376014717 ABC transporter signature motif; other site 762376014718 Walker B; other site 762376014719 D-loop; other site 762376014720 H-loop/switch region; other site 762376014721 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376014722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014723 dimer interface [polypeptide binding]; other site 762376014724 conserved gate region; other site 762376014725 putative PBP binding loops; other site 762376014726 ABC-ATPase subunit interface; other site 762376014727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376014728 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376014729 substrate binding pocket [chemical binding]; other site 762376014730 membrane-bound complex binding site; other site 762376014731 hinge residues; other site 762376014732 Arginase family; Region: Arginase; cl00306 762376014733 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376014734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014735 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014736 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376014737 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376014738 substrate binding pocket [chemical binding]; other site 762376014739 membrane-bound complex binding site; other site 762376014740 hinge residues; other site 762376014741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014743 Coenzyme A transferase; Region: CoA_trans; cl00773 762376014744 Coenzyme A transferase; Region: CoA_trans; cl00773 762376014745 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376014746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014747 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014748 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 762376014749 SUA5 domain; Region: SUA5; pfam03481 762376014750 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762376014751 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014752 AIR carboxylase; Region: AIRC; cl00310 762376014753 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 762376014754 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 762376014755 ATP binding site [chemical binding]; other site 762376014756 active site 762376014757 substrate binding site [chemical binding]; other site 762376014758 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 762376014759 hypothetical protein; Provisional; Region: PRK08185 762376014760 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 762376014761 intersubunit interface [polypeptide binding]; other site 762376014762 active site 762376014763 zinc binding site [ion binding]; other site 762376014764 Na+ binding site [ion binding]; other site 762376014765 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376014766 Strictosidine synthase; Region: Str_synth; pfam03088 762376014767 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 762376014768 MOSC domain; Region: MOSC; pfam03473 762376014769 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 762376014770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376014771 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 762376014772 active site 762376014773 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 762376014774 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762376014775 Walker A/P-loop; other site 762376014776 ATP binding site [chemical binding]; other site 762376014777 Q-loop/lid; other site 762376014778 ABC transporter signature motif; other site 762376014779 Walker B; other site 762376014780 D-loop; other site 762376014781 H-loop/switch region; other site 762376014782 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 762376014783 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376014784 Walker A/P-loop; other site 762376014785 ATP binding site [chemical binding]; other site 762376014786 Q-loop/lid; other site 762376014787 ABC transporter signature motif; other site 762376014788 Walker B; other site 762376014789 D-loop; other site 762376014790 H-loop/switch region; other site 762376014791 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376014792 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 762376014793 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 762376014794 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 762376014795 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 762376014796 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 762376014797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014798 DNA-binding site [nucleotide binding]; DNA binding site 762376014799 UTRA domain; Region: UTRA; cl06649 762376014800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376014801 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 762376014802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376014803 active site 762376014804 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 762376014805 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 762376014806 Guanylate kinase; Region: Guanylate_kin; cl12021 762376014807 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376014808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014810 dimerization interface [polypeptide binding]; other site 762376014811 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376014812 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376014813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014815 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376014816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014817 dimer interface [polypeptide binding]; other site 762376014818 conserved gate region; other site 762376014819 ABC-ATPase subunit interface; other site 762376014820 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 762376014821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014822 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 762376014823 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 762376014824 Walker A/P-loop; other site 762376014825 ATP binding site [chemical binding]; other site 762376014826 Q-loop/lid; other site 762376014827 ABC transporter signature motif; other site 762376014828 Walker B; other site 762376014829 D-loop; other site 762376014830 H-loop/switch region; other site 762376014831 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 762376014832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376014833 dimerization interface [polypeptide binding]; other site 762376014834 putative DNA binding site [nucleotide binding]; other site 762376014835 putative Zn2+ binding site [ion binding]; other site 762376014836 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 762376014837 putative hydrophobic ligand binding site [chemical binding]; other site 762376014838 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762376014839 rRNA binding site [nucleotide binding]; other site 762376014840 predicted 30S ribosome binding site; other site 762376014841 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376014842 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 762376014843 MPT binding site; other site 762376014844 trimer interface [polypeptide binding]; other site 762376014845 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 762376014846 Phosphate transporter family; Region: PHO4; cl00396 762376014847 Phosphate transporter family; Region: PHO4; cl00396 762376014848 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 762376014849 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 762376014850 catalytic residues [active] 762376014851 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376014852 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 762376014853 putative C-terminal domain interface [polypeptide binding]; other site 762376014854 putative GSH binding site (G-site) [chemical binding]; other site 762376014855 putative dimer interface [polypeptide binding]; other site 762376014856 GST_C family, unknown subfamily 8; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_8; cd03207 762376014857 putative N-terminal domain interface [polypeptide binding]; other site 762376014858 putative dimer interface [polypeptide binding]; other site 762376014859 putative substrate binding pocket (H-site) [chemical binding]; other site 762376014860 AzlC protein; Region: AzlC; cl00570 762376014861 chaperone protein DnaJ; Provisional; Region: PRK14276 762376014862 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 762376014863 HSP70 interaction site [polypeptide binding]; other site 762376014864 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 762376014865 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 762376014866 glutathione S-transferase; Provisional; Region: PRK15113 762376014867 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376014868 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 762376014869 substrate binding pocket (H-site) [chemical binding]; other site 762376014870 N-terminal domain interface [polypeptide binding]; other site 762376014871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376014872 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 762376014873 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376014874 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762376014875 Acetokinase family; Region: Acetate_kinase; cl01029 762376014876 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 762376014877 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762376014878 NAD binding site [chemical binding]; other site 762376014879 homotetramer interface [polypeptide binding]; other site 762376014880 homodimer interface [polypeptide binding]; other site 762376014881 substrate binding site [chemical binding]; other site 762376014882 active site 762376014883 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762376014884 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376014885 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376014886 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 762376014887 substrate binding site [chemical binding]; other site 762376014888 hinge regions; other site 762376014889 ADP binding site [chemical binding]; other site 762376014890 catalytic site [active] 762376014891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014892 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 762376014893 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762376014894 transketolase; Reviewed; Region: PRK12753 762376014895 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376014896 TPP-binding site [chemical binding]; other site 762376014897 dimer interface [polypeptide binding]; other site 762376014898 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376014899 PYR/PP interface [polypeptide binding]; other site 762376014900 dimer interface [polypeptide binding]; other site 762376014901 TPP binding site [chemical binding]; other site 762376014902 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376014903 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 762376014904 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 762376014905 putative RNAase interaction site [polypeptide binding]; other site 762376014906 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 762376014907 active site 762376014908 nucleophile elbow; other site 762376014909 malic enzyme; Reviewed; Region: PRK12862 762376014910 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376014911 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376014912 putative NAD(P) binding site [chemical binding]; other site 762376014913 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376014914 aspartate aminotransferase; Provisional; Region: PRK08361 762376014915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376014916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376014917 homodimer interface [polypeptide binding]; other site 762376014918 catalytic residue [active] 762376014919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376014920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376014921 catalytic residue [active] 762376014922 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 762376014923 Abi-like protein; Region: Abi_2; cl01988 762376014924 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 762376014925 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 762376014926 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 762376014927 [4Fe-4S] binding site [ion binding]; other site 762376014928 molybdopterin cofactor binding site; other site 762376014929 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 762376014930 molybdopterin cofactor binding site; other site 762376014931 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 762376014932 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 762376014933 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 762376014934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376014935 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376014936 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 762376014937 Walker A/P-loop; other site 762376014938 ATP binding site [chemical binding]; other site 762376014939 Q-loop/lid; other site 762376014940 ABC transporter signature motif; other site 762376014941 Walker B; other site 762376014942 D-loop; other site 762376014943 H-loop/switch region; other site 762376014944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376014945 dimer interface [polypeptide binding]; other site 762376014946 conserved gate region; other site 762376014947 putative PBP binding loops; other site 762376014948 ABC-ATPase subunit interface; other site 762376014949 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376014950 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376014951 ANTAR domain; Region: ANTAR; pfam03861 762376014952 siroheme synthase; Provisional; Region: cysG; PRK10637 762376014953 precorrin-2 dehydrogenase; Validated; Region: PRK06719 762376014954 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 762376014955 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 762376014956 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376014957 Beta-lactamase; Region: Beta-lactamase; cl01009 762376014958 PBP4 family; Region: PBP4; TIGR00666 762376014959 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376014960 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376014961 putative ligand binding site [chemical binding]; other site 762376014962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014963 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014964 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014965 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762376014966 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 762376014967 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 762376014968 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376014970 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 762376014971 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376014972 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376014973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014975 active site 762376014976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376014977 enoyl-CoA hydratase; Provisional; Region: PRK07468 762376014978 substrate binding site [chemical binding]; other site 762376014979 oxyanion hole (OAH) forming residues; other site 762376014980 trimer interface [polypeptide binding]; other site 762376014981 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376014982 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376014983 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376014984 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376014985 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376014986 carboxyltransferase (CT) interaction site; other site 762376014987 biotinylation site [posttranslational modification]; other site 762376014988 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376014989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376014991 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376014992 Preprotein translocase subunit; Region: YajC; cl00806 762376014993 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 762376014994 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 762376014995 Protein export membrane protein; Region: SecD_SecF; cl14618 762376014996 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 762376014997 Protein export membrane protein; Region: SecD_SecF; cl14618 762376014998 putative transposase OrfB; Reviewed; Region: PHA02517 762376014999 Integrase core domain; Region: rve; cl01316 762376015000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376015001 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 762376015002 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762376015003 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 762376015004 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 762376015005 active site 762376015006 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 762376015007 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762376015008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376015009 FeS/SAM binding site; other site 762376015010 TRAM domain; Region: TRAM; cl01282 762376015011 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762376015012 PhoH-like protein; Region: PhoH; cl12134 762376015013 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 762376015014 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 762376015015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376015016 Transporter associated domain; Region: CorC_HlyC; pfam03471 762376015017 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 762376015018 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 762376015019 putative active site [active] 762376015020 catalytic triad [active] 762376015021 putative dimer interface [polypeptide binding]; other site 762376015022 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376015023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376015024 active site 762376015025 catalytic tetrad [active] 762376015026 hypothetical protein; Provisional; Region: PRK13560 762376015027 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376015028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376015029 DNA binding residues [nucleotide binding] 762376015030 dimerization interface [polypeptide binding]; other site 762376015031 biotin synthetase; Region: bioB; TIGR00433 762376015032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376015033 FeS/SAM binding site; other site 762376015034 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 762376015035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015036 putative MFS family transporter protein; Provisional; Region: PRK03633 762376015037 putative substrate translocation pore; other site 762376015038 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 762376015039 catalytic triad [active] 762376015040 dimer interface [polypeptide binding]; other site 762376015041 Dienelactone hydrolase family; Region: DLH; pfam01738 762376015042 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 762376015043 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376015044 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376015045 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376015046 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376015047 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 762376015048 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 762376015049 trimer interface [polypeptide binding]; other site 762376015050 dimer interface [polypeptide binding]; other site 762376015051 putative active site [active] 762376015052 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 762376015053 MoaE interaction surface [polypeptide binding]; other site 762376015054 MoeB interaction surface [polypeptide binding]; other site 762376015055 thiocarboxylated glycine; other site 762376015056 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 762376015057 MoaE homodimer interface [polypeptide binding]; other site 762376015058 MoaD interaction [polypeptide binding]; other site 762376015059 active site residues [active] 762376015060 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 762376015061 MPT binding site; other site 762376015062 trimer interface [polypeptide binding]; other site 762376015063 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 762376015064 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 762376015065 dimer interface [polypeptide binding]; other site 762376015066 putative functional site; other site 762376015067 putative MPT binding site; other site 762376015068 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 762376015069 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 762376015070 GTP binding site [chemical binding]; other site 762376015071 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762376015072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376015073 FeS/SAM binding site; other site 762376015074 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762376015075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015078 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 762376015079 putative dimer interface [polypeptide binding]; other site 762376015080 [2Fe-2S] cluster binding site [ion binding]; other site 762376015081 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 762376015082 putative dimer interface [polypeptide binding]; other site 762376015083 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 762376015084 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 762376015085 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 762376015086 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 762376015087 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376015088 catalytic loop [active] 762376015089 iron binding site [ion binding]; other site 762376015090 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 762376015091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 762376015092 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 762376015093 [4Fe-4S] binding site [ion binding]; other site 762376015094 molybdopterin cofactor binding site; other site 762376015095 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 762376015096 molybdopterin cofactor binding site; other site 762376015097 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 762376015098 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 762376015099 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 762376015100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015101 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 762376015102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376015103 S-adenosylmethionine binding site [chemical binding]; other site 762376015104 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 762376015105 Chromate transporter; Region: Chromate_transp; pfam02417 762376015106 Chromate transporter; Region: Chromate_transp; pfam02417 762376015107 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376015108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015109 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376015110 putative dimerization interface [polypeptide binding]; other site 762376015111 putative substrate binding pocket [chemical binding]; other site 762376015112 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376015113 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376015114 Ligand Binding Site [chemical binding]; other site 762376015115 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376015116 Ligand Binding Site [chemical binding]; other site 762376015117 sensor protein PhoQ; Provisional; Region: PRK10815 762376015118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376015119 ATP binding site [chemical binding]; other site 762376015120 Mg2+ binding site [ion binding]; other site 762376015121 G-X-G motif; other site 762376015122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376015123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376015124 active site 762376015125 phosphorylation site [posttranslational modification] 762376015126 intermolecular recognition site; other site 762376015127 dimerization interface [polypeptide binding]; other site 762376015128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376015129 DNA binding site [nucleotide binding] 762376015130 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 762376015131 Predicted membrane protein [Function unknown]; Region: COG3212 762376015132 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 762376015133 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 762376015134 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 762376015135 FAD binding pocket [chemical binding]; other site 762376015136 FAD binding motif [chemical binding]; other site 762376015137 phosphate binding motif [ion binding]; other site 762376015138 beta-alpha-beta structure motif; other site 762376015139 NAD binding pocket [chemical binding]; other site 762376015140 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 762376015141 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 762376015142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376015143 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376015144 putative NAD(P) binding site [chemical binding]; other site 762376015145 putative active site [active] 762376015146 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 762376015147 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 762376015148 acyl-CoA synthetase; Validated; Region: PRK08162 762376015149 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376015150 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376015151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015152 DNA-binding site [nucleotide binding]; DNA binding site 762376015153 UTRA domain; Region: UTRA; cl06649 762376015154 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376015155 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376015156 putative ligand binding site [chemical binding]; other site 762376015157 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376015158 dinuclear metal binding motif [ion binding]; other site 762376015159 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015160 TM-ABC transporter signature motif; other site 762376015161 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015162 TM-ABC transporter signature motif; other site 762376015163 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376015164 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376015165 Walker A/P-loop; other site 762376015166 ATP binding site [chemical binding]; other site 762376015167 Q-loop/lid; other site 762376015168 ABC transporter signature motif; other site 762376015169 Walker B; other site 762376015170 D-loop; other site 762376015171 H-loop/switch region; other site 762376015172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376015173 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376015174 Walker A/P-loop; other site 762376015175 ATP binding site [chemical binding]; other site 762376015176 Q-loop/lid; other site 762376015177 ABC transporter signature motif; other site 762376015178 Walker B; other site 762376015179 D-loop; other site 762376015180 H-loop/switch region; other site 762376015181 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762376015182 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 762376015183 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376015184 homotrimer interaction site [polypeptide binding]; other site 762376015185 putative active site [active] 762376015186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376015188 NAD(P) binding site [chemical binding]; other site 762376015189 active site 762376015190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015192 active site 762376015193 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 762376015194 Phosphotransferase enzyme family; Region: APH; pfam01636 762376015195 putative active site [active] 762376015196 putative substrate binding site [chemical binding]; other site 762376015197 ATP binding site [chemical binding]; other site 762376015198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376015199 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 762376015200 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 762376015201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015202 RNA polymerase sigma factor; Provisional; Region: PRK12511 762376015203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376015204 DNA binding residues [nucleotide binding] 762376015205 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 762376015206 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376015207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015208 DNA-binding site [nucleotide binding]; DNA binding site 762376015209 FCD domain; Region: FCD; cl11656 762376015210 urea carboxylase; Region: urea_carbox; TIGR02712 762376015211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376015212 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376015213 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376015214 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 762376015215 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 762376015216 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376015217 carboxyltransferase (CT) interaction site; other site 762376015218 biotinylation site [posttranslational modification]; other site 762376015219 allophanate hydrolase; Provisional; Region: PRK08186 762376015220 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376015221 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376015222 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 762376015223 putative ligand binding site [chemical binding]; other site 762376015224 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015225 TM-ABC transporter signature motif; other site 762376015226 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015227 TM-ABC transporter signature motif; other site 762376015228 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 762376015229 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376015230 Walker A/P-loop; other site 762376015231 ATP binding site [chemical binding]; other site 762376015232 Q-loop/lid; other site 762376015233 ABC transporter signature motif; other site 762376015234 Walker B; other site 762376015235 D-loop; other site 762376015236 H-loop/switch region; other site 762376015237 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 762376015238 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376015239 Walker A/P-loop; other site 762376015240 ATP binding site [chemical binding]; other site 762376015241 Q-loop/lid; other site 762376015242 ABC transporter signature motif; other site 762376015243 Walker B; other site 762376015244 D-loop; other site 762376015245 H-loop/switch region; other site 762376015246 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 762376015247 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015248 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015249 N-terminal plug; other site 762376015250 ligand-binding site [chemical binding]; other site 762376015251 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376015252 catalytic residues [active] 762376015253 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762376015254 active site 762376015255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015257 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762376015258 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 762376015259 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376015260 DNA binding site [nucleotide binding] 762376015261 active site 762376015262 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 762376015263 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 762376015264 AlkA N-terminal domain; Region: AlkA_N; pfam06029 762376015265 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 762376015266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376015267 helix-hairpin-helix signature motif; other site 762376015268 substrate binding pocket [chemical binding]; other site 762376015269 active site 762376015270 transcriptional activator TtdR; Provisional; Region: PRK09801 762376015271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015272 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376015273 putative effector binding pocket; other site 762376015274 putative dimerization interface [polypeptide binding]; other site 762376015275 Protein of unknown function (DUF520); Region: DUF520; cl00723 762376015276 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 762376015277 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376015278 Walker A/P-loop; other site 762376015279 ATP binding site [chemical binding]; other site 762376015280 Q-loop/lid; other site 762376015281 ABC transporter signature motif; other site 762376015282 Walker B; other site 762376015283 D-loop; other site 762376015284 H-loop/switch region; other site 762376015285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376015286 ABC-ATPase subunit interface; other site 762376015287 dimer interface [polypeptide binding]; other site 762376015288 putative PBP binding regions; other site 762376015289 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 762376015290 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 762376015291 putative hemin binding site; other site 762376015292 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 762376015293 ChuX-like family; Region: DUF1008; cl01509 762376015294 ChuX-like family; Region: DUF1008; cl01509 762376015295 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376015296 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 762376015297 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015298 N-terminal plug; other site 762376015299 ligand-binding site [chemical binding]; other site 762376015300 fec operon regulator FecR; Reviewed; Region: PRK09774 762376015301 FecR protein; Region: FecR; pfam04773 762376015302 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376015303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376015305 Copper resistance protein D; Region: CopD; cl00563 762376015306 Predicted transcriptional regulator [Transcription]; Region: COG2378 762376015307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015308 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 762376015309 putative dimer interface [polypeptide binding]; other site 762376015310 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762376015311 kynureninase; Region: kynureninase; TIGR01814 762376015312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376015313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376015314 catalytic residue [active] 762376015315 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376015316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015317 Haemolysin-III related; Region: HlyIII; cl03831 762376015318 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 762376015319 putative active site pocket [active] 762376015320 cleavage site 762376015321 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376015322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376015323 substrate binding pocket [chemical binding]; other site 762376015324 membrane-bound complex binding site; other site 762376015325 hinge residues; other site 762376015326 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376015327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376015328 dimer interface [polypeptide binding]; other site 762376015329 conserved gate region; other site 762376015330 putative PBP binding loops; other site 762376015331 ABC-ATPase subunit interface; other site 762376015332 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376015333 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376015334 Walker A/P-loop; other site 762376015335 ATP binding site [chemical binding]; other site 762376015336 Q-loop/lid; other site 762376015337 ABC transporter signature motif; other site 762376015338 Walker B; other site 762376015339 D-loop; other site 762376015340 H-loop/switch region; other site 762376015341 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 762376015342 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015343 N-terminal plug; other site 762376015344 ligand-binding site [chemical binding]; other site 762376015345 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376015346 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376015347 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 762376015348 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376015349 ABC-ATPase subunit interface; other site 762376015350 dimer interface [polypeptide binding]; other site 762376015351 putative PBP binding regions; other site 762376015352 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 762376015353 intersubunit interface [polypeptide binding]; other site 762376015354 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376015355 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376015356 ligand binding site [chemical binding]; other site 762376015357 flexible hinge region; other site 762376015358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015359 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376015360 putative peptidoglycan binding site; other site 762376015361 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376015362 MASE1; Region: MASE1; pfam05231 762376015363 PAS fold; Region: PAS_3; pfam08447 762376015364 Esterase/lipase [General function prediction only]; Region: COG1647 762376015365 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 762376015366 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376015367 Cu(I) binding site [ion binding]; other site 762376015368 Protein of unknown function (DUF461); Region: DUF461; cl01071 762376015369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376015370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376015371 ATP binding site [chemical binding]; other site 762376015372 G-X-G motif; other site 762376015373 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 762376015374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376015375 active site 762376015376 phosphorylation site [posttranslational modification] 762376015377 intermolecular recognition site; other site 762376015378 dimerization interface [polypeptide binding]; other site 762376015379 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376015380 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 762376015381 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376015382 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 762376015383 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376015384 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 762376015385 D-pathway; other site 762376015386 Putative ubiquinol binding site [chemical binding]; other site 762376015387 Low-spin heme (heme b) binding site [chemical binding]; other site 762376015388 Putative water exit pathway; other site 762376015389 Binuclear center (heme o3/CuB) [ion binding]; other site 762376015390 K-pathway; other site 762376015391 Putative proton exit pathway; other site 762376015392 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 762376015393 Subunit I/III interface [polypeptide binding]; other site 762376015394 Subunit III/IV interface [polypeptide binding]; other site 762376015395 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 762376015396 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376015397 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376015398 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376015399 NifQ; Region: NifQ; pfam04891 762376015400 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015402 N-terminal plug; other site 762376015403 ligand-binding site [chemical binding]; other site 762376015404 SlyX; Region: SlyX; cl01090 762376015405 malic enzyme; Reviewed; Region: PRK12861 762376015406 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376015407 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376015408 putative NAD(P) binding site [chemical binding]; other site 762376015409 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762376015410 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376015411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015413 dimerization interface [polypeptide binding]; other site 762376015414 Cupin domain; Region: Cupin_2; cl09118 762376015415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376015416 EamA-like transporter family; Region: EamA; cl01037 762376015417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015418 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762376015419 MatE; Region: MatE; pfam01554 762376015420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015421 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376015422 putative dimerization interface [polypeptide binding]; other site 762376015423 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376015424 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762376015425 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762376015426 NADP binding site [chemical binding]; other site 762376015427 active site 762376015428 steroid binding site; other site 762376015429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376015430 Coenzyme A binding pocket [chemical binding]; other site 762376015431 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 762376015432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376015433 non-specific DNA binding site [nucleotide binding]; other site 762376015434 salt bridge; other site 762376015435 sequence-specific DNA binding site [nucleotide binding]; other site 762376015436 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 762376015437 putative active site [active] 762376015438 catalytic site [active] 762376015439 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 762376015440 putative active site [active] 762376015441 catalytic site [active] 762376015442 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 762376015443 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 762376015444 Cupin domain; Region: Cupin_2; cl09118 762376015445 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376015446 Cupin domain; Region: Cupin_2; cl09118 762376015447 short chain dehydrogenase; Provisional; Region: PRK06123 762376015448 classical (c) SDRs; Region: SDR_c; cd05233 762376015449 NAD(P) binding site [chemical binding]; other site 762376015450 active site 762376015451 MgtC family; Region: MgtC; cl12207 762376015452 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376015453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015454 NAD(P) binding site [chemical binding]; other site 762376015455 active site 762376015456 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762376015457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376015458 motif II; other site 762376015459 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376015460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376015461 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 762376015462 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 762376015463 DNA interaction; other site 762376015464 Metal-binding active site; metal-binding site 762376015465 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 762376015466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376015467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376015468 aconitate hydratase; Provisional; Region: acnA; PRK12881 762376015469 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376015470 substrate binding site [chemical binding]; other site 762376015471 ligand binding site [chemical binding]; other site 762376015472 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376015473 substrate binding site [chemical binding]; other site 762376015474 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376015475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015476 DNA-binding site [nucleotide binding]; DNA binding site 762376015477 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376015478 FCD domain; Region: FCD; cl11656 762376015479 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376015480 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015482 N-terminal plug; other site 762376015483 ligand-binding site [chemical binding]; other site 762376015484 fec operon regulator FecR; Reviewed; Region: PRK09774 762376015485 FecR protein; Region: FecR; pfam04773 762376015486 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376015487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376015489 DNA binding residues [nucleotide binding] 762376015490 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376015491 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015492 N-terminal plug; other site 762376015493 ligand-binding site [chemical binding]; other site 762376015494 fec operon regulator FecR; Reviewed; Region: PRK09774 762376015495 FecR protein; Region: FecR; pfam04773 762376015496 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376015497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376015499 DNA binding residues [nucleotide binding] 762376015500 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376015501 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376015502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015503 N-terminal plug; other site 762376015504 ligand-binding site [chemical binding]; other site 762376015505 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376015506 FecR protein; Region: FecR; pfam04773 762376015507 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376015508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376015509 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762376015510 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376015511 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 762376015512 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 762376015513 active site 762376015514 Zn binding site [ion binding]; other site 762376015515 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 762376015516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376015517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376015518 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376015519 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 762376015520 NodT family; Region: outer_NodT; TIGR01845 762376015521 Outer membrane efflux protein; Region: OEP; pfam02321 762376015522 Outer membrane efflux protein; Region: OEP; pfam02321 762376015523 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 762376015524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376015525 S-adenosylmethionine binding site [chemical binding]; other site 762376015526 Integral membrane protein TerC family; Region: TerC; cl10468 762376015527 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 762376015528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015530 dimerization interface [polypeptide binding]; other site 762376015531 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 762376015532 cell density-dependent motility repressor; Provisional; Region: PRK10082 762376015533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015535 dimerization interface [polypeptide binding]; other site 762376015536 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 762376015537 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376015538 inhibitor-cofactor binding pocket; inhibition site 762376015539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376015540 catalytic residue [active] 762376015541 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376015542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376015543 substrate binding pocket [chemical binding]; other site 762376015544 membrane-bound complex binding site; other site 762376015545 hinge residues; other site 762376015546 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376015547 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 762376015548 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376015549 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 762376015550 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376015551 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 762376015552 D-pathway; other site 762376015553 Putative ubiquinol binding site [chemical binding]; other site 762376015554 Low-spin heme (heme b) binding site [chemical binding]; other site 762376015555 Putative water exit pathway; other site 762376015556 Binuclear center (heme o3/CuB) [ion binding]; other site 762376015557 K-pathway; other site 762376015558 Putative proton exit pathway; other site 762376015559 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 762376015560 Subunit I/III interface [polypeptide binding]; other site 762376015561 Subunit III/IV interface [polypeptide binding]; other site 762376015562 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 762376015563 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762376015564 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376015565 trimer interface [polypeptide binding]; other site 762376015566 eyelet of channel; other site 762376015567 Putative ParB-like nuclease; Region: ParBc_2; cl01772 762376015568 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376015569 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 762376015570 C-terminal domain interface [polypeptide binding]; other site 762376015571 GSH binding site (G-site) [chemical binding]; other site 762376015572 dimer interface [polypeptide binding]; other site 762376015573 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 762376015574 N-terminal domain interface [polypeptide binding]; other site 762376015575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015576 Predicted transcriptional regulator [Transcription]; Region: COG2378 762376015577 transcriptional regulator RcsB; Provisional; Region: PRK10840 762376015578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376015579 active site 762376015580 phosphorylation site [posttranslational modification] 762376015581 intermolecular recognition site; other site 762376015582 dimerization interface [polypeptide binding]; other site 762376015583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376015584 DNA binding residues [nucleotide binding] 762376015585 dimerization interface [polypeptide binding]; other site 762376015586 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376015587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376015588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015589 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 762376015590 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 762376015591 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376015592 active site 762376015593 metal binding site [ion binding]; metal-binding site 762376015594 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015595 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015596 N-terminal plug; other site 762376015597 ligand-binding site [chemical binding]; other site 762376015598 YCII-related domain; Region: YCII; cl00999 762376015599 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762376015600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762376015601 active site 762376015602 catalytic tetrad [active] 762376015603 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376015604 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 762376015605 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015606 N-terminal plug; other site 762376015607 ligand-binding site [chemical binding]; other site 762376015608 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762376015609 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376015610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376015611 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 762376015612 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376015613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015614 DNA-binding site [nucleotide binding]; DNA binding site 762376015615 UTRA domain; Region: UTRA; cl06649 762376015616 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 762376015617 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376015618 intersubunit interface [polypeptide binding]; other site 762376015619 active site 762376015620 Zn2+ binding site [ion binding]; other site 762376015621 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376015622 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376015623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015625 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376015626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015627 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376015628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015629 active site 762376015630 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376015631 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376015632 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376015633 active site 762376015634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376015635 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376015636 substrate binding site [chemical binding]; other site 762376015637 oxyanion hole (OAH) forming residues; other site 762376015638 trimer interface [polypeptide binding]; other site 762376015639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015640 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376015641 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376015642 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 762376015643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376015644 dimer interface [polypeptide binding]; other site 762376015645 active site 762376015646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015650 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376015651 putative dimerization interface [polypeptide binding]; other site 762376015652 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376015653 enoyl-CoA hydratase; Provisional; Region: PRK06143 762376015654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376015655 substrate binding site [chemical binding]; other site 762376015656 oxyanion hole (OAH) forming residues; other site 762376015657 trimer interface [polypeptide binding]; other site 762376015658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015660 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376015661 putative dimerization interface [polypeptide binding]; other site 762376015662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015664 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376015665 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376015666 thiolase; Provisional; Region: PRK06158 762376015667 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376015668 active site 762376015669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376015670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015671 NAD(P) binding site [chemical binding]; other site 762376015672 active site 762376015673 enoyl-CoA hydratase; Region: PLN02864 762376015674 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376015675 active site 2 [active] 762376015676 active site 1 [active] 762376015677 Coenzyme A transferase; Region: CoA_trans; cl00773 762376015678 Coenzyme A transferase; Region: CoA_trans; cl00773 762376015679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015680 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376015681 active site 762376015682 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015683 active site 762376015684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376015685 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376015686 tetramerization interface [polypeptide binding]; other site 762376015687 NAD(P) binding site [chemical binding]; other site 762376015688 catalytic residues [active] 762376015689 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376015690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015691 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376015692 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376015693 acetyl-CoA acetyltransferase; Provisional; Region: PRK12578 762376015694 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376015695 active site 762376015696 LysE type translocator; Region: LysE; cl00565 762376015697 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 762376015698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376015699 DsrE/DsrF-like family; Region: DrsE; cl00672 762376015700 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 762376015701 active site 762376015702 metal binding site [ion binding]; metal-binding site 762376015703 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376015704 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376015705 catalytic residues [active] 762376015706 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 762376015707 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 762376015708 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 762376015709 Cytochrome c; Region: Cytochrom_C; cl11414 762376015710 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 762376015711 Moco binding site; other site 762376015712 metal coordination site [ion binding]; other site 762376015713 dimerization interface [polypeptide binding]; other site 762376015714 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 762376015715 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 762376015716 Cytochrome c; Region: Cytochrom_C; cl11414 762376015717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015719 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376015720 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376015721 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 762376015722 active site 762376015723 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376015724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015726 dimerization interface [polypeptide binding]; other site 762376015727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015729 tryptophan synthase; Region: PLN02591 762376015730 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 762376015731 substrate binding site [chemical binding]; other site 762376015732 active site 762376015733 catalytic residues [active] 762376015734 heterodimer interface [polypeptide binding]; other site 762376015735 tryptophan synthase, beta chain; Region: PLN02618 762376015736 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762376015737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376015738 catalytic residue [active] 762376015739 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376015740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015742 dimerization interface [polypeptide binding]; other site 762376015743 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762376015744 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 762376015745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015746 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015747 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376015748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015751 GAF domain; Region: GAF; cl00853 762376015752 LytTr DNA-binding domain; Region: LytTR; cl04498 762376015753 Beta-lactamase; Region: Beta-lactamase; cl01009 762376015754 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376015755 Beta-lactamase; Region: Beta-lactamase; cl01009 762376015756 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 762376015757 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376015758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376015759 S-adenosylmethionine binding site [chemical binding]; other site 762376015760 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 762376015761 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762376015762 TPP-binding site [chemical binding]; other site 762376015763 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 762376015764 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 762376015765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376015766 Beta-Casp domain; Region: Beta-Casp; pfam10996 762376015767 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762376015768 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015769 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015770 N-terminal plug; other site 762376015771 ligand-binding site [chemical binding]; other site 762376015772 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 762376015773 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762376015774 putative ligand binding residues [chemical binding]; other site 762376015775 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 762376015776 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376015777 Walker A/P-loop; other site 762376015778 ATP binding site [chemical binding]; other site 762376015779 Q-loop/lid; other site 762376015780 ABC transporter signature motif; other site 762376015781 Walker B; other site 762376015782 D-loop; other site 762376015783 H-loop/switch region; other site 762376015784 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 762376015785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376015786 ABC-ATPase subunit interface; other site 762376015787 dimer interface [polypeptide binding]; other site 762376015788 putative PBP binding regions; other site 762376015789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762376015790 ABC-ATPase subunit interface; other site 762376015791 dimer interface [polypeptide binding]; other site 762376015792 putative PBP binding regions; other site 762376015793 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376015794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376015795 Walker A/P-loop; other site 762376015796 ATP binding site [chemical binding]; other site 762376015797 Q-loop/lid; other site 762376015798 ABC transporter signature motif; other site 762376015799 Walker B; other site 762376015800 D-loop; other site 762376015801 H-loop/switch region; other site 762376015802 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376015803 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376015804 Walker A/P-loop; other site 762376015805 ATP binding site [chemical binding]; other site 762376015806 Q-loop/lid; other site 762376015807 ABC transporter signature motif; other site 762376015808 Walker B; other site 762376015809 D-loop; other site 762376015810 H-loop/switch region; other site 762376015811 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 762376015812 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 762376015813 C-terminal domain interface [polypeptide binding]; other site 762376015814 GSH binding site (G-site) [chemical binding]; other site 762376015815 dimer interface [polypeptide binding]; other site 762376015816 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 762376015817 dimer interface [polypeptide binding]; other site 762376015818 N-terminal domain interface [polypeptide binding]; other site 762376015819 putative substrate binding pocket (H-site) [chemical binding]; other site 762376015820 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 762376015821 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762376015822 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376015823 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 762376015824 C-terminal domain interface [polypeptide binding]; other site 762376015825 GSH binding site (G-site) [chemical binding]; other site 762376015826 dimer interface [polypeptide binding]; other site 762376015827 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 762376015828 N-terminal domain interface [polypeptide binding]; other site 762376015829 dimer interface [polypeptide binding]; other site 762376015830 substrate binding pocket (H-site) [chemical binding]; other site 762376015831 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 762376015832 active site 762376015833 oxalacetate binding site [chemical binding]; other site 762376015834 citrylCoA binding site [chemical binding]; other site 762376015835 coenzyme A binding site [chemical binding]; other site 762376015836 catalytic triad [active] 762376015837 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 762376015838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015839 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376015840 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376015841 active site 2 [active] 762376015842 active site 1 [active] 762376015843 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376015844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015845 NAD(P) binding site [chemical binding]; other site 762376015846 active site 762376015847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376015850 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376015851 NAD(P) binding site [chemical binding]; other site 762376015852 catalytic residues [active] 762376015853 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376015854 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 762376015855 active site 762376015856 NAD binding site [chemical binding]; other site 762376015857 metal binding site [ion binding]; metal-binding site 762376015858 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376015859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015860 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 762376015861 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376015862 FMN binding site [chemical binding]; other site 762376015863 substrate binding site [chemical binding]; other site 762376015864 putative catalytic residue [active] 762376015865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015867 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015868 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015869 active site 762376015870 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376015871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376015873 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376015874 FecR protein; Region: FecR; pfam04773 762376015875 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376015876 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376015877 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015878 N-terminal plug; other site 762376015879 ligand-binding site [chemical binding]; other site 762376015880 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376015881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376015882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376015883 Putative cyclase; Region: Cyclase; cl00814 762376015884 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376015885 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376015886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015887 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376015888 putative effector binding pocket; other site 762376015889 dimerization interface [polypeptide binding]; other site 762376015890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015891 OsmC-like protein; Region: OsmC; cl00767 762376015892 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 762376015893 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 762376015894 catalytic residues [active] 762376015895 Spore Coat Protein U domain; Region: SCPU; cl02253 762376015896 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376015897 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376015898 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 762376015899 Spore Coat Protein U domain; Region: SCPU; cl02253 762376015900 putative mechanosensitive channel protein; Provisional; Region: PRK11465 762376015901 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376015902 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376015903 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376015904 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 762376015905 dimer interface [polypeptide binding]; other site 762376015906 N-terminal domain interface [polypeptide binding]; other site 762376015907 substrate binding pocket (H-site) [chemical binding]; other site 762376015908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015909 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 762376015910 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 762376015911 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376015912 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376015913 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376015914 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015915 N-terminal plug; other site 762376015916 ligand-binding site [chemical binding]; other site 762376015917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015918 dimerization interface [polypeptide binding]; other site 762376015919 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376015920 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 762376015921 metal binding site [ion binding]; metal-binding site 762376015922 putative dimer interface [polypeptide binding]; other site 762376015923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015925 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376015926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376015927 PYR/PP interface [polypeptide binding]; other site 762376015928 dimer interface [polypeptide binding]; other site 762376015929 TPP binding site [chemical binding]; other site 762376015930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376015931 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762376015932 TPP-binding site [chemical binding]; other site 762376015933 aspartate aminotransferase; Provisional; Region: PRK08361 762376015934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376015935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376015936 homodimer interface [polypeptide binding]; other site 762376015937 catalytic residue [active] 762376015938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376015941 dimerization interface [polypeptide binding]; other site 762376015942 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376015943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015944 DNA-binding site [nucleotide binding]; DNA binding site 762376015945 FCD domain; Region: FCD; cl11656 762376015946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015948 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376015949 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376015950 MlrC C-terminus; Region: MlrC_C; pfam07171 762376015951 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376015952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376015953 catalytic residue [active] 762376015954 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376015955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376015956 Walker A/P-loop; other site 762376015957 ATP binding site [chemical binding]; other site 762376015958 Q-loop/lid; other site 762376015959 ABC transporter signature motif; other site 762376015960 Walker B; other site 762376015961 D-loop; other site 762376015962 H-loop/switch region; other site 762376015963 TOBE domain; Region: TOBE_2; cl01440 762376015964 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376015965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376015966 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376015967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376015968 dimer interface [polypeptide binding]; other site 762376015969 conserved gate region; other site 762376015970 putative PBP binding loops; other site 762376015971 ABC-ATPase subunit interface; other site 762376015972 Arginase family; Region: Arginase; cl00306 762376015973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376015974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015975 putative substrate translocation pore; other site 762376015976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376015977 metal binding site [ion binding]; metal-binding site 762376015978 active site 762376015979 I-site; other site 762376015980 EamA-like transporter family; Region: EamA; cl01037 762376015981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376015982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376015983 Predicted transcriptional regulator [Transcription]; Region: COG1959 762376015984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376015986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015987 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376015988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015989 putative substrate translocation pore; other site 762376015990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376015992 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 762376015993 putative effector binding pocket; other site 762376015994 putative dimerization interface [polypeptide binding]; other site 762376015995 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 762376015996 oligomerisation interface [polypeptide binding]; other site 762376015997 mobile loop; other site 762376015998 roof hairpin; other site 762376015999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762376016000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762376016001 ring oligomerisation interface [polypeptide binding]; other site 762376016002 ATP/Mg binding site [chemical binding]; other site 762376016003 stacking interactions; other site 762376016004 hinge regions; other site 762376016005 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 762376016006 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376016007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016008 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376016009 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376016010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376016011 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376016012 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376016013 NAD binding site [chemical binding]; other site 762376016014 catalytic residues [active] 762376016015 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376016016 homotrimer interaction site [polypeptide binding]; other site 762376016017 putative active site [active] 762376016018 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376016019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016021 dimerization interface [polypeptide binding]; other site 762376016022 Cupin domain; Region: Cupin_2; cl09118 762376016023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376016024 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376016025 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 762376016026 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 762376016027 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 762376016028 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 762376016029 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 762376016030 putative active site pocket [active] 762376016031 putative metal binding site [ion binding]; other site 762376016032 galactarate dehydratase; Region: galactar-dH20; TIGR03248 762376016033 SAF domain; Region: SAF; cl00555 762376016034 SAF domain; Region: SAF; cl00555 762376016035 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376016036 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376016037 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376016038 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 762376016039 NAD binding site [chemical binding]; other site 762376016040 homotetramer interface [polypeptide binding]; other site 762376016041 homodimer interface [polypeptide binding]; other site 762376016042 active site 762376016043 DctM-like transporters; Region: DctM; pfam06808 762376016044 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376016045 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376016046 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 762376016047 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 762376016048 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 762376016049 putative NAD(P) binding site [chemical binding]; other site 762376016050 catalytic Zn binding site [ion binding]; other site 762376016051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376016052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016053 DNA-binding site [nucleotide binding]; DNA binding site 762376016054 FCD domain; Region: FCD; cl11656 762376016055 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 762376016056 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762376016057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376016058 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 762376016059 active site 762376016060 dimer interface [polypeptide binding]; other site 762376016061 Competence-damaged protein; Region: CinA; cl00666 762376016062 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762376016063 tetramer interfaces [polypeptide binding]; other site 762376016064 binuclear metal-binding site [ion binding]; other site 762376016065 thiamine monophosphate kinase; Provisional; Region: PRK05731 762376016066 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 762376016067 ATP binding site [chemical binding]; other site 762376016068 dimerization interface [polypeptide binding]; other site 762376016069 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 762376016070 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 762376016071 homopentamer interface [polypeptide binding]; other site 762376016072 active site 762376016073 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 762376016074 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 762376016075 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 762376016076 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 762376016077 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 762376016078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016079 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016080 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376016081 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376016082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376016083 substrate binding pocket [chemical binding]; other site 762376016084 membrane-bound complex binding site; other site 762376016085 hinge residues; other site 762376016086 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 762376016087 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 762376016088 Walker A/P-loop; other site 762376016089 ATP binding site [chemical binding]; other site 762376016090 Q-loop/lid; other site 762376016091 ABC transporter signature motif; other site 762376016092 Walker B; other site 762376016093 D-loop; other site 762376016094 H-loop/switch region; other site 762376016095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376016096 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376016097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376016098 dimer interface [polypeptide binding]; other site 762376016099 conserved gate region; other site 762376016100 ABC-ATPase subunit interface; other site 762376016101 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376016102 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376016103 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376016104 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376016105 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376016106 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376016107 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376016108 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376016109 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376016110 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 762376016111 putative active site [active] 762376016112 putative metal binding residues [ion binding]; other site 762376016113 signature motif; other site 762376016114 putative triphosphate binding site [ion binding]; other site 762376016115 CHAD domain; Region: CHAD; cl10506 762376016116 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762376016117 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762376016118 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762376016119 P loop; other site 762376016120 GTP binding site [chemical binding]; other site 762376016121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376016122 S-adenosylmethionine binding site [chemical binding]; other site 762376016123 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 762376016124 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762376016125 active site 762376016126 (T/H)XGH motif; other site 762376016127 ferredoxin; Validated; Region: PRK07118 762376016128 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 762376016129 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376016130 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 762376016131 AsmA family; Region: AsmA; pfam05170 762376016132 AsmA family; Region: AsmA; pfam05170 762376016133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376016135 putative substrate translocation pore; other site 762376016136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016137 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376016138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016139 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376016140 GTP-binding protein YchF; Reviewed; Region: PRK09601 762376016141 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 762376016142 G1 box; other site 762376016143 GTP/Mg2+ binding site [chemical binding]; other site 762376016144 Switch I region; other site 762376016145 G2 box; other site 762376016146 Switch II region; other site 762376016147 G3 box; other site 762376016148 G4 box; other site 762376016149 G5 box; other site 762376016150 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762376016151 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762376016152 putative active site [active] 762376016153 catalytic residue [active] 762376016154 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 762376016155 5S rRNA interface [nucleotide binding]; other site 762376016156 CTC domain interface; other site 762376016157 L16 interface [polypeptide binding]; other site 762376016158 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 762376016159 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376016160 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 762376016161 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 762376016162 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 762376016163 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 762376016164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376016165 binding surface 762376016166 TPR motif; other site 762376016167 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762376016168 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762376016169 DNA binding site [nucleotide binding] 762376016170 catalytic residue [active] 762376016171 H2TH interface [polypeptide binding]; other site 762376016172 putative catalytic residues [active] 762376016173 turnover-facilitating residue; other site 762376016174 intercalation triad [nucleotide binding]; other site 762376016175 8OG recognition residue [nucleotide binding]; other site 762376016176 putative reading head residues; other site 762376016177 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762376016178 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762376016179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376016180 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376016181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376016182 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 762376016183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016185 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376016186 substrate binding pocket [chemical binding]; other site 762376016187 dimerization interface [polypeptide binding]; other site 762376016188 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 762376016189 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 762376016190 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 762376016191 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376016192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762376016193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 762376016194 putative acyl-acceptor binding pocket; other site 762376016195 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762376016196 Sulfatase; Region: Sulfatase; cl10460 762376016197 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376016198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016199 DNA-binding site [nucleotide binding]; DNA binding site 762376016200 FCD domain; Region: FCD; cl11656 762376016201 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 762376016202 active site 762376016203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376016204 dimer interface [polypeptide binding]; other site 762376016205 phosphorylation site [posttranslational modification] 762376016206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376016207 ATP binding site [chemical binding]; other site 762376016208 Mg2+ binding site [ion binding]; other site 762376016209 G-X-G motif; other site 762376016210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376016211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376016212 active site 762376016213 phosphorylation site [posttranslational modification] 762376016214 intermolecular recognition site; other site 762376016215 dimerization interface [polypeptide binding]; other site 762376016216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376016217 DNA binding site [nucleotide binding] 762376016218 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376016219 FAD binding domain; Region: FAD_binding_4; pfam01565 762376016220 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376016221 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 762376016222 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 762376016223 active site 762376016224 substrate binding site [chemical binding]; other site 762376016225 metal binding site [ion binding]; metal-binding site 762376016226 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 762376016227 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762376016228 active site 762376016229 dimer interface [polypeptide binding]; other site 762376016230 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762376016231 dimer interface [polypeptide binding]; other site 762376016232 active site 762376016233 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 762376016234 putative ADP-binding pocket [chemical binding]; other site 762376016235 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 762376016236 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 762376016237 putative ADP-binding pocket [chemical binding]; other site 762376016238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376016239 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762376016240 putative ADP-binding pocket [chemical binding]; other site 762376016241 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 762376016242 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 762376016243 active site 762376016244 dimer interface [polypeptide binding]; other site 762376016245 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 762376016246 Ligand Binding Site [chemical binding]; other site 762376016247 Molecular Tunnel; other site 762376016248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376016249 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762376016250 putative ADP-binding pocket [chemical binding]; other site 762376016251 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 762376016252 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 762376016253 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 762376016254 NAD binding site [chemical binding]; other site 762376016255 substrate binding site [chemical binding]; other site 762376016256 homodimer interface [polypeptide binding]; other site 762376016257 active site 762376016258 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 762376016259 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376016260 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376016261 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 762376016262 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases...; Region: GT_MraY_like; cd06912 762376016263 Mg++ binding site [ion binding]; other site 762376016264 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 762376016265 putative catalytic motif [active] 762376016266 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 762376016267 diiron binding motif [ion binding]; other site 762376016268 OsmC-like protein; Region: OsmC; cl00767 762376016269 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762376016270 dimerization interface [polypeptide binding]; other site 762376016271 active site 762376016272 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 762376016273 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 762376016274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376016275 metal binding site [ion binding]; metal-binding site 762376016276 active site 762376016277 I-site; other site 762376016278 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376016279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 762376016280 folate binding site [chemical binding]; other site 762376016281 NADP+ binding site [chemical binding]; other site 762376016282 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376016283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016284 DNA-binding site [nucleotide binding]; DNA binding site 762376016285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016287 homodimer interface [polypeptide binding]; other site 762376016288 catalytic residue [active] 762376016289 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 762376016290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376016291 inhibitor-cofactor binding pocket; inhibition site 762376016292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016293 catalytic residue [active] 762376016294 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376016295 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376016296 tetrameric interface [polypeptide binding]; other site 762376016297 NAD binding site [chemical binding]; other site 762376016298 catalytic residues [active] 762376016299 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376016300 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376016301 MlrC C-terminus; Region: MlrC_C; pfam07171 762376016302 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376016303 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376016304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376016305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376016306 dimer interface [polypeptide binding]; other site 762376016307 conserved gate region; other site 762376016308 putative PBP binding loops; other site 762376016309 ABC-ATPase subunit interface; other site 762376016310 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376016311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376016312 dimer interface [polypeptide binding]; other site 762376016313 conserved gate region; other site 762376016314 putative PBP binding loops; other site 762376016315 ABC-ATPase subunit interface; other site 762376016316 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376016317 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376016318 Walker A/P-loop; other site 762376016319 ATP binding site [chemical binding]; other site 762376016320 Q-loop/lid; other site 762376016321 ABC transporter signature motif; other site 762376016322 Walker B; other site 762376016323 D-loop; other site 762376016324 H-loop/switch region; other site 762376016325 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376016326 Walker A/P-loop; other site 762376016327 ATP binding site [chemical binding]; other site 762376016328 Q-loop/lid; other site 762376016329 ABC transporter signature motif; other site 762376016330 Walker B; other site 762376016331 D-loop; other site 762376016332 H-loop/switch region; other site 762376016333 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376016334 amidase; Provisional; Region: PRK07042 762376016335 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376016336 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376016337 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376016338 MlrC C-terminus; Region: MlrC_C; pfam07171 762376016339 hypothetical protein; Provisional; Region: PRK11367 762376016340 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 762376016341 glycine dehydrogenase; Provisional; Region: PRK05367 762376016342 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 762376016343 tetramer interface [polypeptide binding]; other site 762376016344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016345 catalytic residue [active] 762376016346 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 762376016347 tetramer interface [polypeptide binding]; other site 762376016348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016349 catalytic residue [active] 762376016350 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 762376016351 lipoyl attachment site [posttranslational modification]; other site 762376016352 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 762376016353 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762376016354 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 762376016355 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 762376016356 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762376016357 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762376016358 Predicted flavoproteins [General function prediction only]; Region: COG2081 762376016359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376016360 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 762376016361 lysine decarboxylase LdcC; Provisional; Region: PRK15399 762376016362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376016363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376016364 catalytic residue [active] 762376016365 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 762376016366 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376016367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376016368 Coenzyme A binding pocket [chemical binding]; other site 762376016369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376016370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376016371 metal binding site [ion binding]; metal-binding site 762376016372 active site 762376016373 I-site; other site 762376016374 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376016375 active site 762376016376 metal binding site [ion binding]; metal-binding site 762376016377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376016378 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762376016379 trimer interface [polypeptide binding]; other site 762376016380 active site 762376016381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 762376016382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 762376016383 Family of unknown function (DUF490); Region: DUF490; pfam04357 762376016384 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 762376016385 Surface antigen; Region: Bac_surface_Ag; cl03097 762376016386 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762376016387 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 762376016388 Walker A motif; other site 762376016389 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 762376016390 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762376016391 active site 762376016392 HIGH motif; other site 762376016393 KMSKS motif; other site 762376016394 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762376016395 tRNA binding surface [nucleotide binding]; other site 762376016396 anticodon binding site; other site 762376016397 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762376016398 dimer interface [polypeptide binding]; other site 762376016399 putative tRNA-binding site [nucleotide binding]; other site 762376016400 rhodanese superfamily protein; Provisional; Region: PRK05320 762376016401 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 762376016402 active site residue [active] 762376016403 META domain; Region: META; cl01245 762376016404 META domain; Region: META; cl01245 762376016405 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762376016406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376016407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376016408 sequence-specific DNA binding site [nucleotide binding]; other site 762376016409 salt bridge; other site 762376016410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376016411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 762376016412 phosphorylation site [posttranslational modification] 762376016413 intermolecular recognition site; other site 762376016414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 762376016415 voltage-gated potassium channel; Provisional; Region: PRK10537 762376016416 Ion channel; Region: Ion_trans_2; cl11596 762376016417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016418 phage resistance protein; Provisional; Region: PRK10551 762376016419 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 762376016420 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376016421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376016422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376016423 NodT family; Region: outer_NodT; TIGR01845 762376016424 Outer membrane efflux protein; Region: OEP; pfam02321 762376016425 Outer membrane efflux protein; Region: OEP; pfam02321 762376016426 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 762376016427 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 762376016428 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376016429 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762376016430 Walker A/P-loop; other site 762376016431 ATP binding site [chemical binding]; other site 762376016432 Q-loop/lid; other site 762376016433 ABC transporter signature motif; other site 762376016434 Walker B; other site 762376016435 D-loop; other site 762376016436 H-loop/switch region; other site 762376016437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376016438 Walker A/P-loop; other site 762376016439 ATP binding site [chemical binding]; other site 762376016440 Q-loop/lid; other site 762376016441 ABC transporter signature motif; other site 762376016442 Walker B; other site 762376016443 D-loop; other site 762376016444 H-loop/switch region; other site 762376016445 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376016446 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376016447 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762376016448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376016449 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762376016450 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 762376016451 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376016452 NAD(P) binding site [chemical binding]; other site 762376016453 homotetramer interface [polypeptide binding]; other site 762376016454 homodimer interface [polypeptide binding]; other site 762376016455 active site 762376016456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016457 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376016458 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376016459 putative effector binding pocket; other site 762376016460 dimerization interface [polypeptide binding]; other site 762376016461 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762376016462 dimer interface [polypeptide binding]; other site 762376016463 FMN binding site [chemical binding]; other site 762376016464 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376016465 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 762376016466 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376016467 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376016468 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376016469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016470 DNA-binding site [nucleotide binding]; DNA binding site 762376016471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016473 homodimer interface [polypeptide binding]; other site 762376016474 catalytic residue [active] 762376016475 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376016476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376016477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376016478 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376016479 FecR protein; Region: FecR; pfam04773 762376016480 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376016481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016482 N-terminal plug; other site 762376016483 ligand-binding site [chemical binding]; other site 762376016484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016486 tricarballylate utilization protein B; Provisional; Region: PRK15033 762376016487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376016488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016490 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376016491 putative dimerization interface [polypeptide binding]; other site 762376016492 Cytochrome c [Energy production and conversion]; Region: COG3258 762376016493 Cytochrome c; Region: Cytochrom_C; cl11414 762376016494 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376016495 Cytochrome c; Region: Cytochrom_C; cl11414 762376016496 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376016497 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 762376016498 C-terminal domain interface [polypeptide binding]; other site 762376016499 GSH binding site (G-site) [chemical binding]; other site 762376016500 dimer interface [polypeptide binding]; other site 762376016501 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 762376016502 dimer interface [polypeptide binding]; other site 762376016503 N-terminal domain interface [polypeptide binding]; other site 762376016504 putative substrate binding pocket (H-site) [chemical binding]; other site 762376016505 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 762376016506 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 762376016507 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376016508 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 762376016509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376016510 Walker A motif; other site 762376016511 ATP binding site [chemical binding]; other site 762376016512 Walker B motif; other site 762376016513 arginine finger; other site 762376016514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376016515 Walker A motif; other site 762376016516 ATP binding site [chemical binding]; other site 762376016517 Walker B motif; other site 762376016518 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376016519 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 762376016520 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 762376016521 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 762376016522 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 762376016523 Protein of unknown function (DUF796); Region: DUF796; cl01226 762376016524 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 762376016525 Protein of unknown function (DUF877); Region: DUF877; pfam05943 762376016526 Protein of unknown function (DUF770); Region: DUF770; cl01402 762376016527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762376016528 TPR motif; other site 762376016529 binding surface 762376016530 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 762376016531 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 762376016532 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 762376016533 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 762376016534 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 762376016535 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376016536 putative metal dependent hydrolase; Provisional; Region: PRK11598 762376016537 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376016538 putative active site [active] 762376016539 catalytic site [active] 762376016540 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376016541 putative active site [active] 762376016542 catalytic site [active] 762376016543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 762376016544 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 762376016545 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376016546 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 762376016547 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 762376016548 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 762376016549 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 762376016550 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 762376016551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376016552 ligand binding site [chemical binding]; other site 762376016553 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 762376016554 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 762376016555 Uncharacterized conserved protein [Function unknown]; Region: COG4104 762376016556 PAAR motif; Region: PAAR_motif; pfam05488 762376016557 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 762376016558 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 762376016559 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 762376016560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376016561 metal binding site [ion binding]; metal-binding site 762376016562 active site 762376016563 I-site; other site 762376016564 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 762376016565 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376016566 dimer interface [polypeptide binding]; other site 762376016567 PYR/PP interface [polypeptide binding]; other site 762376016568 TPP binding site [chemical binding]; other site 762376016569 substrate binding site [chemical binding]; other site 762376016570 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 762376016571 TPP-binding site; other site 762376016572 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 762376016573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016575 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376016576 putative substrate binding pocket [chemical binding]; other site 762376016577 dimerization interface [polypeptide binding]; other site 762376016578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016580 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376016581 putative dimerization interface [polypeptide binding]; other site 762376016582 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 762376016583 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376016584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016585 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 762376016586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376016587 Walker A motif; other site 762376016588 ATP binding site [chemical binding]; other site 762376016589 Walker B motif; other site 762376016590 arginine finger; other site 762376016591 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376016592 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376016593 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376016594 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376016595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016596 DNA-binding site [nucleotide binding]; DNA binding site 762376016597 FCD domain; Region: FCD; cl11656 762376016598 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 762376016599 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376016600 substrate binding site [chemical binding]; other site 762376016601 ligand binding site [chemical binding]; other site 762376016602 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376016603 substrate binding site [chemical binding]; other site 762376016604 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 762376016605 Peptidase family M48; Region: Peptidase_M48; cl12018 762376016606 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376016607 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376016608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016611 dimerization interface [polypeptide binding]; other site 762376016612 cytosine deaminase; Provisional; Region: PRK05985 762376016613 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 762376016614 active site 762376016615 Sodium:solute symporter family; Region: SSF; cl00456 762376016616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376016617 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376016618 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376016619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376016620 active site 762376016621 phosphorylation site [posttranslational modification] 762376016622 intermolecular recognition site; other site 762376016623 dimerization interface [polypeptide binding]; other site 762376016624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376016625 DNA binding site [nucleotide binding] 762376016626 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376016627 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762376016628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376016629 dimer interface [polypeptide binding]; other site 762376016630 phosphorylation site [posttranslational modification] 762376016631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376016632 ATP binding site [chemical binding]; other site 762376016633 Mg2+ binding site [ion binding]; other site 762376016634 G-X-G motif; other site 762376016635 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376016636 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376016637 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376016638 Multicopper oxidase; Region: Cu-oxidase; cl14658 762376016639 multicopper oxidase; Provisional; Region: PRK10965 762376016640 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 762376016641 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376016642 metal-binding site [ion binding] 762376016643 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376016644 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376016645 metal-binding site [ion binding] 762376016646 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376016647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376016648 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762376016649 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 762376016650 active sites [active] 762376016651 tetramer interface [polypeptide binding]; other site 762376016652 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 762376016653 Prostaglandin dehydrogenases; Region: PGDH; cd05288 762376016654 NAD(P) binding site [chemical binding]; other site 762376016655 substrate binding site [chemical binding]; other site 762376016656 dimer interface [polypeptide binding]; other site 762376016657 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762376016658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016661 dimerization interface [polypeptide binding]; other site 762376016662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376016665 dimerization interface [polypeptide binding]; other site 762376016666 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 762376016667 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376016668 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376016669 active site 762376016670 intersubunit interface [polypeptide binding]; other site 762376016671 Zn2+ binding site [ion binding]; other site 762376016672 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762376016673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016674 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762376016675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016677 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376016678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376016679 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 762376016680 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 762376016681 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 762376016682 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376016683 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 762376016684 dimer interface [polypeptide binding]; other site 762376016685 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762376016686 active site 762376016687 folate binding site [chemical binding]; other site 762376016688 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376016689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016690 DNA-binding site [nucleotide binding]; DNA binding site 762376016691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016693 homodimer interface [polypeptide binding]; other site 762376016694 catalytic residue [active] 762376016695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376016696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376016697 catalytic residue [active] 762376016698 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376016699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016700 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376016701 dimerization interface [polypeptide binding]; other site 762376016702 substrate binding pocket [chemical binding]; other site 762376016703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016705 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376016706 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376016707 inhibitor site; inhibition site 762376016708 active site 762376016709 dimer interface [polypeptide binding]; other site 762376016710 catalytic residue [active] 762376016711 Cupin domain; Region: Cupin_2; cl09118 762376016712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016714 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376016715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016716 DNA-binding site [nucleotide binding]; DNA binding site 762376016717 FCD domain; Region: FCD; cl11656 762376016718 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762376016719 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762376016720 catalytic triad [active] 762376016721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 762376016722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376016723 catalytic residue [active] 762376016724 Cupin domain; Region: Cupin_2; cl09118 762376016725 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376016726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376016727 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376016728 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376016729 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376016730 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 762376016731 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 762376016732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016733 DNA-binding site [nucleotide binding]; DNA binding site 762376016734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016736 homodimer interface [polypeptide binding]; other site 762376016737 catalytic residue [active] 762376016738 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 762376016739 lysine decarboxylase LdcC; Provisional; Region: PRK15399 762376016740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376016741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376016742 catalytic residue [active] 762376016743 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 762376016744 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376016745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016746 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376016747 putative dimerization interface [polypeptide binding]; other site 762376016748 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376016749 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376016750 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 762376016751 active site 762376016752 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376016753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376016754 dimer interface [polypeptide binding]; other site 762376016755 conserved gate region; other site 762376016756 ABC-ATPase subunit interface; other site 762376016757 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376016758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016759 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376016760 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376016761 Walker A/P-loop; other site 762376016762 ATP binding site [chemical binding]; other site 762376016763 Q-loop/lid; other site 762376016764 ABC transporter signature motif; other site 762376016765 Walker B; other site 762376016766 D-loop; other site 762376016767 H-loop/switch region; other site 762376016768 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376016769 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376016770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016771 Histidine kinase; Region: His_kinase; pfam06580 762376016772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 762376016773 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762376016774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376016775 active site 762376016776 phosphorylation site [posttranslational modification] 762376016777 intermolecular recognition site; other site 762376016778 dimerization interface [polypeptide binding]; other site 762376016779 LytTr DNA-binding domain; Region: LytTR; cl04498 762376016780 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376016781 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376016782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016787 dimerization interface [polypeptide binding]; other site 762376016788 Cache domain; Region: Cache_1; pfam02743 762376016789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376016790 metal binding site [ion binding]; metal-binding site 762376016791 active site 762376016792 I-site; other site 762376016793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016795 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376016796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016798 homodimer interface [polypeptide binding]; other site 762376016799 catalytic residue [active] 762376016800 M28, and M42; Region: Zinc_peptidase_like; cl14876 762376016801 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376016802 metal binding site [ion binding]; metal-binding site 762376016803 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376016804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376016805 substrate binding site [chemical binding]; other site 762376016806 oxyanion hole (OAH) forming residues; other site 762376016807 trimer interface [polypeptide binding]; other site 762376016808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016811 active site 762376016812 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376016813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016816 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016817 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376016818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376016819 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376016820 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376016821 conserved cys residue [active] 762376016822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376016823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376016824 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376016825 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 762376016826 C-term; Region: GreA_GreB; pfam01272 762376016827 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 762376016828 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 762376016829 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 762376016830 molybdopterin cofactor binding site [chemical binding]; other site 762376016831 substrate binding site [chemical binding]; other site 762376016832 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 762376016833 molybdopterin cofactor binding site; other site 762376016834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016836 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376016837 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376016838 putative NAD(P) binding site [chemical binding]; other site 762376016839 putative active site [active] 762376016840 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376016841 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376016842 dimer interface [polypeptide binding]; other site 762376016843 active site 762376016844 catalytic residue [active] 762376016845 cystathionine beta-lyase; Provisional; Region: PRK09028 762376016846 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376016847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376016848 catalytic residue [active] 762376016849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016850 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376016851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376016852 dimerization interface [polypeptide binding]; other site 762376016853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376016854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376016856 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 762376016857 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 762376016858 thiS-thiF/thiG interaction site; other site 762376016859 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 762376016860 BON domain; Region: BON; cl02771 762376016861 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376016862 putative peptidoglycan binding site; other site 762376016863 signal recognition particle protein; Provisional; Region: PRK10867 762376016864 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762376016865 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762376016866 GTP binding site [chemical binding]; other site 762376016867 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762376016868 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376016869 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762376016870 amidase catalytic site [active] 762376016871 Zn binding residues [ion binding]; other site 762376016872 substrate binding site [chemical binding]; other site 762376016873 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376016874 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376016875 putative C-terminal domain interface [polypeptide binding]; other site 762376016876 putative GSH binding site (G-site) [chemical binding]; other site 762376016877 putative dimer interface [polypeptide binding]; other site 762376016878 GST_C family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_2; cd03180 762376016879 putative N-terminal domain interface [polypeptide binding]; other site 762376016880 putative dimer interface [polypeptide binding]; other site 762376016881 putative substrate binding pocket (H-site) [chemical binding]; other site 762376016882 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016884 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376016885 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 762376016886 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 762376016887 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 762376016888 active site 762376016889 intersubunit interface [polypeptide binding]; other site 762376016890 catalytic residue [active] 762376016891 galactonate dehydratase; Provisional; Region: PRK14017 762376016892 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 762376016893 putative active site pocket [active] 762376016894 putative metal binding site [ion binding]; other site 762376016895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016896 D-galactonate transporter; Region: 2A0114; TIGR00893 762376016897 putative substrate translocation pore; other site 762376016898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016899 putative substrate translocation pore; other site 762376016900 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016902 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376016903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016905 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376016906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016908 active site 762376016909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016914 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376016915 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376016916 active site 762376016917 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 762376016918 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376016919 NADP binding site [chemical binding]; other site 762376016920 dimer interface [polypeptide binding]; other site 762376016921 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376016922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016923 HipA N-terminal domain; Region: couple_hipA; TIGR03071 762376016924 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376016925 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376016926 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376016927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376016928 heat shock protein 90; Provisional; Region: PRK05218 762376016929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376016930 ATP binding site [chemical binding]; other site 762376016931 Mg2+ binding site [ion binding]; other site 762376016932 G-X-G motif; other site 762376016933 Permease family; Region: Xan_ur_permease; pfam00860 762376016934 Sulfate transporter family; Region: Sulfate_transp; cl00967 762376016935 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762376016936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376016937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376016938 motif II; other site 762376016939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016941 glutathionine S-transferase; Provisional; Region: PRK10542 762376016942 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 762376016943 C-terminal domain interface [polypeptide binding]; other site 762376016944 GSH binding site (G-site) [chemical binding]; other site 762376016945 dimer interface [polypeptide binding]; other site 762376016946 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 762376016947 dimer interface [polypeptide binding]; other site 762376016948 N-terminal domain interface [polypeptide binding]; other site 762376016949 substrate binding pocket (H-site) [chemical binding]; other site 762376016950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376016952 dimerization interface [polypeptide binding]; other site 762376016953 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 762376016954 multidrug resistance protein MdtN; Provisional; Region: PRK10476 762376016955 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 762376016956 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 762376016957 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762376016958 Outer membrane efflux protein; Region: OEP; pfam02321 762376016959 Outer membrane efflux protein; Region: OEP; pfam02321 762376016960 Predicted membrane protein [Function unknown]; Region: COG1289 762376016961 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376016962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376016963 substrate binding pocket [chemical binding]; other site 762376016964 membrane-bound complex binding site; other site 762376016965 hinge residues; other site 762376016966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376016968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016969 dimerization interface [polypeptide binding]; other site 762376016970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376016971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016972 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376016973 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376016974 MlrC C-terminus; Region: MlrC_C; pfam07171 762376016975 PPIC-type PPIASE domain; Region: Rotamase; cl08278 762376016976 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376016977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376016978 Walker A/P-loop; other site 762376016979 ATP binding site [chemical binding]; other site 762376016980 Q-loop/lid; other site 762376016981 ABC transporter signature motif; other site 762376016982 Walker B; other site 762376016983 D-loop; other site 762376016984 H-loop/switch region; other site 762376016985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 762376016986 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376016987 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762376016988 TM-ABC transporter signature motif; other site 762376016989 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762376016990 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762376016991 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 762376016992 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 762376016993 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376016994 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376016995 putative ligand binding site [chemical binding]; other site 762376016996 classical (c) SDRs; Region: SDR_c; cd05233 762376016997 NAD(P) binding site [chemical binding]; other site 762376016998 active site 762376016999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017002 dimerization interface [polypeptide binding]; other site 762376017003 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376017004 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 762376017005 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376017006 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 762376017007 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 762376017008 Cupin domain; Region: Cupin_2; cl09118 762376017009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017010 putative substrate translocation pore; other site 762376017011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376017012 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376017013 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376017014 tetramer interface [polypeptide binding]; other site 762376017015 active site 762376017016 Mg2+/Mn2+ binding site [ion binding]; other site 762376017017 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376017018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017019 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376017020 putative dimerization interface [polypeptide binding]; other site 762376017021 putative substrate binding pocket [chemical binding]; other site 762376017022 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 762376017023 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 762376017024 FAD binding pocket [chemical binding]; other site 762376017025 FAD binding motif [chemical binding]; other site 762376017026 phosphate binding motif [ion binding]; other site 762376017027 NAD binding pocket [chemical binding]; other site 762376017028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017029 EamA-like transporter family; Region: EamA; cl01037 762376017030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376017031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017032 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376017033 putative substrate translocation pore; other site 762376017034 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 762376017035 Domain of unknown function DUF20; Region: UPF0118; cl00465 762376017036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017038 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376017039 putative effector binding pocket; other site 762376017040 putative dimerization interface [polypeptide binding]; other site 762376017041 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376017042 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 762376017043 NodT family; Region: outer_NodT; TIGR01845 762376017044 Outer membrane efflux protein; Region: OEP; pfam02321 762376017045 Outer membrane efflux protein; Region: OEP; pfam02321 762376017046 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376017047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017049 dimerization interface [polypeptide binding]; other site 762376017050 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 762376017051 Cupin domain; Region: Cupin_2; cl09118 762376017052 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376017053 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 762376017054 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376017055 C-terminal domain interface [polypeptide binding]; other site 762376017056 GSH binding site (G-site) [chemical binding]; other site 762376017057 putative dimer interface [polypeptide binding]; other site 762376017058 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 762376017059 dimer interface [polypeptide binding]; other site 762376017060 N-terminal domain interface [polypeptide binding]; other site 762376017061 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 762376017062 Chorismate mutase type II; Region: CM_2; cl00693 762376017063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017064 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 762376017065 salicylate hydroxylase; Provisional; Region: PRK08163 762376017066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376017067 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017068 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376017069 putative ligand binding site [chemical binding]; other site 762376017070 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376017071 TM-ABC transporter signature motif; other site 762376017072 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376017073 TM-ABC transporter signature motif; other site 762376017074 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376017075 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376017076 Walker A/P-loop; other site 762376017077 ATP binding site [chemical binding]; other site 762376017078 Q-loop/lid; other site 762376017079 ABC transporter signature motif; other site 762376017080 Walker B; other site 762376017081 D-loop; other site 762376017082 H-loop/switch region; other site 762376017083 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376017084 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376017085 Walker A/P-loop; other site 762376017086 ATP binding site [chemical binding]; other site 762376017087 Q-loop/lid; other site 762376017088 ABC transporter signature motif; other site 762376017089 Walker B; other site 762376017090 D-loop; other site 762376017091 H-loop/switch region; other site 762376017092 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 762376017093 dimer interface [polypeptide binding]; other site 762376017094 ligand binding site [chemical binding]; other site 762376017095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017097 enoyl-CoA hydratase; Provisional; Region: PRK05995 762376017098 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376017099 substrate binding site [chemical binding]; other site 762376017100 oxyanion hole (OAH) forming residues; other site 762376017101 trimer interface [polypeptide binding]; other site 762376017102 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376017103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017106 dimerization interface [polypeptide binding]; other site 762376017107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017109 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376017110 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762376017111 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376017112 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376017113 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376017114 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376017115 carboxyltransferase (CT) interaction site; other site 762376017116 biotinylation site [posttranslational modification]; other site 762376017117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376017118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376017119 active site 762376017120 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 762376017121 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376017122 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376017123 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376017124 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762376017125 Walker A/P-loop; other site 762376017126 ATP binding site [chemical binding]; other site 762376017127 Q-loop/lid; other site 762376017128 ABC transporter signature motif; other site 762376017129 Walker B; other site 762376017130 D-loop; other site 762376017131 H-loop/switch region; other site 762376017132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376017133 dimer interface [polypeptide binding]; other site 762376017134 conserved gate region; other site 762376017135 putative PBP binding loops; other site 762376017136 ABC-ATPase subunit interface; other site 762376017137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376017138 conserved gate region; other site 762376017139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376017140 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376017141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376017142 substrate binding pocket [chemical binding]; other site 762376017143 membrane-bound complex binding site; other site 762376017144 hinge residues; other site 762376017145 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 762376017146 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376017147 Walker A/P-loop; other site 762376017148 ATP binding site [chemical binding]; other site 762376017149 Q-loop/lid; other site 762376017150 ABC transporter signature motif; other site 762376017151 Walker B; other site 762376017152 D-loop; other site 762376017153 H-loop/switch region; other site 762376017154 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 762376017155 CheD chemotactic sensory transduction; Region: CheD; cl00810 762376017156 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 762376017157 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 762376017158 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 762376017159 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 762376017160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017161 SAF domain; Region: SAF; cl00555 762376017162 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376017163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017164 DNA-binding site [nucleotide binding]; DNA binding site 762376017165 FCD domain; Region: FCD; cl11656 762376017166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376017167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017168 NAD(P) binding site [chemical binding]; other site 762376017169 active site 762376017170 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762376017171 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376017172 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376017173 shikimate binding site; other site 762376017174 NAD(P) binding site [chemical binding]; other site 762376017175 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017176 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 762376017177 putative ligand binding site [chemical binding]; other site 762376017178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376017179 TM-ABC transporter signature motif; other site 762376017180 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376017181 TM-ABC transporter signature motif; other site 762376017182 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376017183 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376017184 Walker A/P-loop; other site 762376017185 ATP binding site [chemical binding]; other site 762376017186 Q-loop/lid; other site 762376017187 ABC transporter signature motif; other site 762376017188 Walker B; other site 762376017189 D-loop; other site 762376017190 H-loop/switch region; other site 762376017191 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376017192 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376017193 Walker A/P-loop; other site 762376017194 ATP binding site [chemical binding]; other site 762376017195 Q-loop/lid; other site 762376017196 ABC transporter signature motif; other site 762376017197 Walker B; other site 762376017198 D-loop; other site 762376017199 H-loop/switch region; other site 762376017200 short chain dehydrogenase; Provisional; Region: PRK06841 762376017201 classical (c) SDRs; Region: SDR_c; cd05233 762376017202 NAD(P) binding site [chemical binding]; other site 762376017203 active site 762376017204 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376017205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376017206 tetramer interface [polypeptide binding]; other site 762376017207 TPP-binding site [chemical binding]; other site 762376017208 heterodimer interface [polypeptide binding]; other site 762376017209 phosphorylation loop region [posttranslational modification] 762376017210 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376017211 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376017212 alpha subunit interface [polypeptide binding]; other site 762376017213 TPP binding site [chemical binding]; other site 762376017214 heterodimer interface [polypeptide binding]; other site 762376017215 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376017216 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762376017217 active site 762376017218 metal binding site [ion binding]; metal-binding site 762376017219 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376017220 E3 interaction surface; other site 762376017221 lipoyl attachment site [posttranslational modification]; other site 762376017222 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376017223 e3 binding domain; Region: E3_binding; pfam02817 762376017224 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762376017225 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762376017226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376017227 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376017228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017231 dimerization interface [polypeptide binding]; other site 762376017232 Dehydratase family; Region: ILVD_EDD; cl00340 762376017233 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 762376017234 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376017235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017236 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376017237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017238 dimerization interface [polypeptide binding]; other site 762376017239 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376017240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376017241 Coenzyme A binding pocket [chemical binding]; other site 762376017242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 762376017243 putative substrate translocation pore; other site 762376017244 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 762376017245 Ligand Binding Site [chemical binding]; other site 762376017246 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 762376017247 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 762376017248 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376017249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762376017250 DNA binding residues [nucleotide binding] 762376017251 fec operon regulator FecR; Reviewed; Region: PRK09774 762376017252 FecR protein; Region: FecR; pfam04773 762376017253 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376017254 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017255 N-terminal plug; other site 762376017256 ligand-binding site [chemical binding]; other site 762376017257 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 762376017258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376017260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376017261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376017262 classical (c) SDRs; Region: SDR_c; cd05233 762376017263 NAD(P) binding site [chemical binding]; other site 762376017264 active site 762376017265 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376017266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017267 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376017268 Coenzyme A transferase; Region: CoA_trans; cl00773 762376017269 Coenzyme A transferase; Region: CoA_trans; cl00773 762376017270 Muconolactone delta-isomerase; Region: MIase; cl01992 762376017271 YCII-related domain; Region: YCII; cl00999 762376017272 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376017273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376017274 Putative cyclase; Region: Cyclase; cl00814 762376017275 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 762376017276 Flavoprotein; Region: Flavoprotein; cl08021 762376017277 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 762376017278 putative GSH binding site [chemical binding]; other site 762376017279 catalytic residues [active] 762376017280 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762376017281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376017282 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762376017283 RF-1 domain; Region: RF-1; cl02875 762376017284 RF-1 domain; Region: RF-1; cl02875 762376017285 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 762376017286 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 762376017287 tRNA; other site 762376017288 putative tRNA binding site [nucleotide binding]; other site 762376017289 putative NADP binding site [chemical binding]; other site 762376017290 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 762376017291 Isochorismatase family; Region: Isochorismatase; pfam00857 762376017292 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376017293 catalytic triad [active] 762376017294 conserved cis-peptide bond; other site 762376017295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017297 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376017298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017299 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376017300 dimerization interface [polypeptide binding]; other site 762376017301 substrate binding pocket [chemical binding]; other site 762376017302 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 762376017303 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376017304 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376017305 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376017306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376017307 Walker A/P-loop; other site 762376017308 ATP binding site [chemical binding]; other site 762376017309 Q-loop/lid; other site 762376017310 ABC transporter signature motif; other site 762376017311 Walker B; other site 762376017312 D-loop; other site 762376017313 H-loop/switch region; other site 762376017314 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376017315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376017316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376017317 Abi-like protein; Region: Abi_2; cl01988 762376017318 RNA polymerase sigma factor; Provisional; Region: PRK11922 762376017319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376017320 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 762376017321 Predicted outer membrane protein [Function unknown]; Region: COG3652 762376017322 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376017323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017324 LysE type translocator; Region: LysE; cl00565 762376017325 threonine and homoserine efflux system; Provisional; Region: PRK10532 762376017326 EamA-like transporter family; Region: EamA; cl01037 762376017327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017329 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 762376017330 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376017331 active site 762376017332 catalytic residues [active] 762376017333 metal binding site [ion binding]; metal-binding site 762376017334 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376017335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376017336 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376017337 Walker A/P-loop; other site 762376017338 ATP binding site [chemical binding]; other site 762376017339 Q-loop/lid; other site 762376017340 ABC transporter signature motif; other site 762376017341 Walker B; other site 762376017342 D-loop; other site 762376017343 H-loop/switch region; other site 762376017344 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376017345 TM-ABC transporter signature motif; other site 762376017346 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376017347 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376017348 Walker A/P-loop; other site 762376017349 ATP binding site [chemical binding]; other site 762376017350 Q-loop/lid; other site 762376017351 ABC transporter signature motif; other site 762376017352 Walker B; other site 762376017353 D-loop; other site 762376017354 H-loop/switch region; other site 762376017355 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376017356 TM-ABC transporter signature motif; other site 762376017357 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017358 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376017359 choline dehydrogenase; Validated; Region: PRK02106 762376017360 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376017361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376017362 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376017363 tetramerization interface [polypeptide binding]; other site 762376017364 NAD(P) binding site [chemical binding]; other site 762376017365 catalytic residues [active] 762376017366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017368 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376017369 putative dimerization interface [polypeptide binding]; other site 762376017370 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376017371 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017372 N-terminal plug; other site 762376017373 ligand-binding site [chemical binding]; other site 762376017374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017375 DNA-binding site [nucleotide binding]; DNA binding site 762376017376 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376017377 FCD domain; Region: FCD; cl11656 762376017378 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 762376017379 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376017380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017381 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762376017382 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 762376017383 putative NAD(P) binding site [chemical binding]; other site 762376017384 active site 762376017385 putative substrate binding site [chemical binding]; other site 762376017386 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 762376017387 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 762376017388 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762376017389 intersubunit interface [polypeptide binding]; other site 762376017390 active site 762376017391 Zn2+ binding site [ion binding]; other site 762376017392 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376017393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017394 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376017395 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017396 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376017397 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376017398 TM-ABC transporter signature motif; other site 762376017399 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376017400 TM-ABC transporter signature motif; other site 762376017401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376017402 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376017403 Walker A/P-loop; other site 762376017404 ATP binding site [chemical binding]; other site 762376017405 Q-loop/lid; other site 762376017406 ABC transporter signature motif; other site 762376017407 Walker B; other site 762376017408 D-loop; other site 762376017409 H-loop/switch region; other site 762376017410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376017411 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376017412 Walker A/P-loop; other site 762376017413 ATP binding site [chemical binding]; other site 762376017414 Q-loop/lid; other site 762376017415 ABC transporter signature motif; other site 762376017416 Walker B; other site 762376017417 D-loop; other site 762376017418 H-loop/switch region; other site 762376017419 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376017420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017421 DNA-binding site [nucleotide binding]; DNA binding site 762376017422 FCD domain; Region: FCD; cl11656 762376017423 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762376017424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376017425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376017426 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376017427 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376017428 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 762376017429 Isochorismatase family; Region: Isochorismatase; pfam00857 762376017430 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376017431 catalytic triad [active] 762376017432 conserved cis-peptide bond; other site 762376017433 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 762376017434 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762376017435 Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302 762376017436 active site 762376017437 tetramer interface [polypeptide binding]; other site 762376017438 aconitate hydratase; Validated; Region: PRK09277 762376017439 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376017440 substrate binding site [chemical binding]; other site 762376017441 ligand binding site [chemical binding]; other site 762376017442 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376017443 substrate binding site [chemical binding]; other site 762376017444 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376017445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017446 DNA-binding site [nucleotide binding]; DNA binding site 762376017447 FCD domain; Region: FCD; cl11656 762376017448 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 762376017449 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376017450 tetramer interface [polypeptide binding]; other site 762376017451 active site 762376017452 Mg2+/Mn2+ binding site [ion binding]; other site 762376017453 classical (c) SDRs; Region: SDR_c; cd05233 762376017454 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 762376017455 NAD(P) binding site [chemical binding]; other site 762376017456 active site 762376017457 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376017458 classical (c) SDRs; Region: SDR_c; cd05233 762376017459 NAD(P) binding site [chemical binding]; other site 762376017460 active site 762376017461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017463 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376017464 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017465 N-terminal plug; other site 762376017466 ligand-binding site [chemical binding]; other site 762376017467 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 762376017468 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 762376017469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 762376017470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017471 ATP binding site [chemical binding]; other site 762376017472 Mg2+ binding site [ion binding]; other site 762376017473 G-X-G motif; other site 762376017474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376017475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017476 active site 762376017477 phosphorylation site [posttranslational modification] 762376017478 intermolecular recognition site; other site 762376017479 dimerization interface [polypeptide binding]; other site 762376017480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376017481 DNA binding residues [nucleotide binding] 762376017482 dimerization interface [polypeptide binding]; other site 762376017483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376017484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376017485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017486 active site 762376017487 phosphorylation site [posttranslational modification] 762376017488 intermolecular recognition site; other site 762376017489 dimerization interface [polypeptide binding]; other site 762376017490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376017491 DNA binding residues [nucleotide binding] 762376017492 dimerization interface [polypeptide binding]; other site 762376017493 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 762376017494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 762376017495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017496 ATP binding site [chemical binding]; other site 762376017497 Mg2+ binding site [ion binding]; other site 762376017498 G-X-G motif; other site 762376017499 Response regulator receiver domain; Region: Response_reg; pfam00072 762376017500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017501 active site 762376017502 phosphorylation site [posttranslational modification] 762376017503 intermolecular recognition site; other site 762376017504 dimerization interface [polypeptide binding]; other site 762376017505 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 762376017506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376017507 dimer interface [polypeptide binding]; other site 762376017508 phosphorylation site [posttranslational modification] 762376017509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017510 ATP binding site [chemical binding]; other site 762376017511 Mg2+ binding site [ion binding]; other site 762376017512 G-X-G motif; other site 762376017513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017514 Response regulator receiver domain; Region: Response_reg; pfam00072 762376017515 active site 762376017516 phosphorylation site [posttranslational modification] 762376017517 intermolecular recognition site; other site 762376017518 dimerization interface [polypeptide binding]; other site 762376017519 Fimbrial protein; Region: Fimbrial; cl01416 762376017520 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376017521 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376017522 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 762376017523 Fimbrial Usher protein; Region: Usher; pfam00577 762376017524 Fimbrial protein; Region: Fimbrial; cl01416 762376017525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 762376017526 Fimbrial protein; Region: Fimbrial; cl01416 762376017527 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 762376017528 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376017529 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376017530 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 762376017531 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376017532 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 762376017533 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376017534 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376017535 Fimbrial protein; Region: Fimbrial; cl01416 762376017536 haemagglutination activity domain; Region: Haemagg_act; cl05436 762376017537 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 762376017538 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376017539 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 762376017540 Surface antigen; Region: Bac_surface_Ag; cl03097 762376017541 transcriptional regulator RcsB; Provisional; Region: PRK10840 762376017542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 762376017543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 762376017544 DNA binding residues [nucleotide binding] 762376017545 dimerization interface [polypeptide binding]; other site 762376017546 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 762376017547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376017548 dimer interface [polypeptide binding]; other site 762376017549 phosphorylation site [posttranslational modification] 762376017550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017551 ATP binding site [chemical binding]; other site 762376017552 Mg2+ binding site [ion binding]; other site 762376017553 G-X-G motif; other site 762376017554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017555 active site 762376017556 phosphorylation site [posttranslational modification] 762376017557 intermolecular recognition site; other site 762376017558 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 762376017559 Sulfatase; Region: Sulfatase; cl10460 762376017560 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376017561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017564 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376017565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017566 dimerization interface [polypeptide binding]; other site 762376017567 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376017568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017571 Sulfatase; Region: Sulfatase; cl10460 762376017572 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376017573 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 762376017574 putative active site [active] 762376017575 putative metal binding site [ion binding]; other site 762376017576 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 762376017577 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762376017578 substrate binding pocket [chemical binding]; other site 762376017579 chain length determination region; other site 762376017580 substrate-Mg2+ binding site; other site 762376017581 catalytic residues [active] 762376017582 aspartate-rich region 1; other site 762376017583 active site lid residues [active] 762376017584 aspartate-rich region 2; other site 762376017585 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 762376017586 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376017587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376017589 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376017590 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 762376017591 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 762376017592 GTPase CgtA; Reviewed; Region: obgE; PRK12299 762376017593 GTP1/OBG; Region: GTP1_OBG; pfam01018 762376017594 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 762376017595 G1 box; other site 762376017596 GTP/Mg2+ binding site [chemical binding]; other site 762376017597 Switch I region; other site 762376017598 G2 box; other site 762376017599 G3 box; other site 762376017600 Switch II region; other site 762376017601 G4 box; other site 762376017602 G5 box; other site 762376017603 gamma-glutamyl kinase; Provisional; Region: PRK05429 762376017604 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 762376017605 nucleotide binding site [chemical binding]; other site 762376017606 homotetrameric interface [polypeptide binding]; other site 762376017607 putative phosphate binding site [ion binding]; other site 762376017608 putative allosteric binding site; other site 762376017609 PUA domain; Region: PUA; cl00607 762376017610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376017611 non-specific DNA binding site [nucleotide binding]; other site 762376017612 salt bridge; other site 762376017613 sequence-specific DNA binding site [nucleotide binding]; other site 762376017614 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 762376017615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376017616 putative transposase OrfB; Reviewed; Region: PHA02517 762376017617 Integrase core domain; Region: rve; cl01316 762376017618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376017619 protein-export membrane protein SecD; Region: secD; TIGR01129 762376017620 ThiC family; Region: ThiC; cl08031 762376017621 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376017622 FAD binding domain; Region: FAD_binding_4; pfam01565 762376017623 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376017624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017625 DNA-binding site [nucleotide binding]; DNA binding site 762376017626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376017627 metal binding site [ion binding]; metal-binding site 762376017628 active site 762376017629 I-site; other site 762376017630 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 762376017631 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 762376017632 ATP binding site [chemical binding]; other site 762376017633 substrate interface [chemical binding]; other site 762376017634 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 762376017635 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762376017636 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762376017637 protein binding site [polypeptide binding]; other site 762376017638 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 762376017639 Catalytic dyad [active] 762376017640 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 762376017641 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376017642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376017643 catalytic core [active] 762376017644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376017645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762376017646 active site residue [active] 762376017647 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 762376017648 GSH binding site [chemical binding]; other site 762376017649 catalytic residues [active] 762376017650 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 762376017651 SecA binding site; other site 762376017652 Preprotein binding site; other site 762376017653 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762376017654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017655 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762376017656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017658 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762376017659 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376017660 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 762376017661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376017662 S-adenosylmethionine binding site [chemical binding]; other site 762376017663 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 762376017664 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 762376017665 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 762376017666 Cation transport protein; Region: TrkH; cl10514 762376017667 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 762376017668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017670 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376017671 Response regulator receiver domain; Region: Response_reg; pfam00072 762376017672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017673 active site 762376017674 phosphorylation site [posttranslational modification] 762376017675 intermolecular recognition site; other site 762376017676 dimerization interface [polypeptide binding]; other site 762376017677 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376017678 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 762376017679 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 762376017680 dimerization interface [polypeptide binding]; other site 762376017681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 762376017682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017683 ATP binding site [chemical binding]; other site 762376017684 Mg2+ binding site [ion binding]; other site 762376017685 G-X-G motif; other site 762376017686 16S rRNA methyltransferase B; Provisional; Region: PRK10901 762376017687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376017688 LysE type translocator; Region: LysE; cl00565 762376017689 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376017690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017691 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376017692 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376017693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376017694 substrate binding site [chemical binding]; other site 762376017695 oxyanion hole (OAH) forming residues; other site 762376017696 trimer interface [polypeptide binding]; other site 762376017697 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 762376017698 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 762376017699 B12 binding site [chemical binding]; other site 762376017700 cobalt ligand [ion binding]; other site 762376017701 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376017702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376017703 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762376017704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017706 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017707 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376017708 putative ligand binding site [chemical binding]; other site 762376017709 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 762376017710 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 762376017711 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376017712 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 762376017713 NAD(P) binding site [chemical binding]; other site 762376017714 catalytic residues [active] 762376017715 catalytic residues [active] 762376017716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376017717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017718 NAD(P) binding site [chemical binding]; other site 762376017719 active site 762376017720 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 762376017721 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376017722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376017723 active site 762376017724 phosphorylation site [posttranslational modification] 762376017725 intermolecular recognition site; other site 762376017726 dimerization interface [polypeptide binding]; other site 762376017727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376017728 DNA binding site [nucleotide binding] 762376017729 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376017730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376017731 dimer interface [polypeptide binding]; other site 762376017732 phosphorylation site [posttranslational modification] 762376017733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017734 ATP binding site [chemical binding]; other site 762376017735 Mg2+ binding site [ion binding]; other site 762376017736 G-X-G motif; other site 762376017737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376017738 non-specific DNA binding site [nucleotide binding]; other site 762376017739 salt bridge; other site 762376017740 sequence-specific DNA binding site [nucleotide binding]; other site 762376017741 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 762376017742 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762376017743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 762376017744 FeS/SAM binding site; other site 762376017745 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376017746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017747 Ferritin-like domain; Region: Ferritin; pfam00210 762376017748 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376017749 dinuclear metal binding motif [ion binding]; other site 762376017750 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 762376017751 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376017752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762376017753 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376017754 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762376017755 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762376017756 putative active site [active] 762376017757 substrate binding site [chemical binding]; other site 762376017758 putative cosubstrate binding site; other site 762376017759 catalytic site [active] 762376017760 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762376017761 substrate binding site [chemical binding]; other site 762376017762 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 762376017763 active site 762376017764 catalytic residues [active] 762376017765 metal binding site [ion binding]; metal-binding site 762376017766 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 762376017767 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 762376017768 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376017769 active site 762376017770 catalytic residues [active] 762376017771 metal binding site [ion binding]; metal-binding site 762376017772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762376017773 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376017774 substrate binding pocket [chemical binding]; other site 762376017775 membrane-bound complex binding site; other site 762376017776 hinge residues; other site 762376017777 methionine aminotransferase; Validated; Region: PRK09082 762376017778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376017779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017780 homodimer interface [polypeptide binding]; other site 762376017781 catalytic residue [active] 762376017782 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 762376017783 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376017784 catalytic residue [active] 762376017785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017787 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 762376017788 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376017789 FAD binding domain; Region: FAD_binding_4; pfam01565 762376017790 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 762376017791 C subunit; Region: glycerol3P_GlpC; TIGR03379 762376017792 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762376017793 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 762376017794 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376017795 threonine dehydratase; Reviewed; Region: PRK09224 762376017796 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376017797 tetramer interface [polypeptide binding]; other site 762376017798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017799 catalytic residue [active] 762376017800 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 762376017801 putative Ile/Val binding site [chemical binding]; other site 762376017802 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 762376017803 putative Ile/Val binding site [chemical binding]; other site 762376017804 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 762376017805 trimer interface [polypeptide binding]; other site 762376017806 eyelet of channel; other site 762376017807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376017808 putative transposase OrfB; Reviewed; Region: PHA02517 762376017809 Integrase core domain; Region: rve; cl01316 762376017810 transcriptional regulator; Provisional; Region: PRK10632 762376017811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017812 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376017813 putative effector binding pocket; other site 762376017814 dimerization interface [polypeptide binding]; other site 762376017815 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376017816 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 762376017817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376017818 Walker A/P-loop; other site 762376017819 ATP binding site [chemical binding]; other site 762376017820 Q-loop/lid; other site 762376017821 ABC transporter signature motif; other site 762376017822 Walker B; other site 762376017823 D-loop; other site 762376017824 H-loop/switch region; other site 762376017825 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 762376017826 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762376017827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376017828 Walker A/P-loop; other site 762376017829 ATP binding site [chemical binding]; other site 762376017830 Q-loop/lid; other site 762376017831 ABC transporter signature motif; other site 762376017832 Walker B; other site 762376017833 D-loop; other site 762376017834 H-loop/switch region; other site 762376017835 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 762376017836 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376017837 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376017838 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 762376017839 Predicted transcriptional regulators [Transcription]; Region: COG1510 762376017840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017841 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 762376017842 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376017843 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376017844 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 762376017845 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 762376017846 putative active site [active] 762376017847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 762376017848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376017849 active site 762376017850 motif I; other site 762376017851 motif II; other site 762376017852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 762376017853 OstA-like protein; Region: OstA; cl00844 762376017854 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 762376017855 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 762376017856 Walker A/P-loop; other site 762376017857 ATP binding site [chemical binding]; other site 762376017858 Q-loop/lid; other site 762376017859 ABC transporter signature motif; other site 762376017860 Walker B; other site 762376017861 D-loop; other site 762376017862 H-loop/switch region; other site 762376017863 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 762376017864 30S subunit binding site; other site 762376017865 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762376017866 active site 762376017867 phosphorylation site [posttranslational modification] 762376017868 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762376017869 DRTGG domain; Region: DRTGG; cl12147 762376017870 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 762376017871 Hpr binding site; other site 762376017872 active site 762376017873 homohexamer subunit interaction site [polypeptide binding]; other site 762376017874 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376017875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017876 DNA-binding site [nucleotide binding]; DNA binding site 762376017877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376017878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017879 homodimer interface [polypeptide binding]; other site 762376017880 catalytic residue [active] 762376017881 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376017882 Cytochrome c; Region: Cytochrom_C; cl11414 762376017883 Cytochrome c; Region: Cytochrom_C; cl11414 762376017884 Cytochrome c; Region: Cytochrom_C; cl11414 762376017885 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 762376017886 rare lipoprotein A; Provisional; Region: PRK10672 762376017887 rare lipoprotein A; Region: rlpA; TIGR00413 762376017888 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 762376017889 Sporulation related domain; Region: SPOR; cl10051 762376017890 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 762376017891 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376017892 DNA binding site [nucleotide binding] 762376017893 active site 762376017894 Predicted methyltransferases [General function prediction only]; Region: COG0313 762376017895 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 762376017896 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 762376017897 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 762376017898 dimer interface [polypeptide binding]; other site 762376017899 active site 762376017900 BON domain; Region: BON; cl02771 762376017901 BON domain; Region: BON; cl02771 762376017902 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 762376017903 catalytic residues [active] 762376017904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017905 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 762376017906 homohexameric interface [polypeptide binding]; other site 762376017907 feedback inhibition sensing region; other site 762376017908 nucleotide binding site [chemical binding]; other site 762376017909 N-acetyl-L-glutamate binding site [chemical binding]; other site 762376017910 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762376017911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762376017912 motif II; other site 762376017913 division inhibitor protein; Provisional; Region: slmA; PRK09480 762376017914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376017915 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 762376017916 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 762376017917 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762376017918 transmembrane helices; other site 762376017919 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376017920 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 762376017921 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 762376017922 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762376017923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762376017924 rod shape-determining protein MreD; Region: MreD; cl01087 762376017925 rod shape-determining protein MreC; Provisional; Region: PRK13922 762376017926 rod shape-determining protein MreC; Region: MreC; pfam04085 762376017927 rod shape-determining protein MreB; Provisional; Region: PRK13927 762376017928 Cell division protein FtsA; Region: FtsA; cl11496 762376017929 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 762376017930 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376017931 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762376017932 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762376017933 GatB domain; Region: GatB_Yqey; cl11497 762376017934 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 762376017935 putative active site [active] 762376017936 homotetrameric interface [polypeptide binding]; other site 762376017937 metal binding site [ion binding]; metal-binding site 762376017938 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762376017939 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 762376017940 putative active site [active] 762376017941 putative DNA binding site [nucleotide binding]; other site 762376017942 putative phosphate binding site [ion binding]; other site 762376017943 putative catalytic site [active] 762376017944 metal binding site A [ion binding]; metal-binding site 762376017945 putative AP binding site [nucleotide binding]; other site 762376017946 putative metal binding site B [ion binding]; other site 762376017947 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376017948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017950 dimerization interface [polypeptide binding]; other site 762376017951 LysE type translocator; Region: LysE; cl00565 762376017952 glutamate dehydrogenase; Provisional; Region: PRK09414 762376017953 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 762376017954 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 762376017955 NAD(P) binding site [chemical binding]; other site 762376017956 Protein of unknown function (DUF461); Region: DUF461; cl01071 762376017957 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 762376017958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017960 dimerization interface [polypeptide binding]; other site 762376017961 LysE type translocator; Region: LysE; cl00565 762376017962 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 762376017963 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376017964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017966 dimerization interface [polypeptide binding]; other site 762376017967 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376017968 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 762376017969 putative ligand binding site [chemical binding]; other site 762376017970 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376017971 TM-ABC transporter signature motif; other site 762376017972 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376017973 TM-ABC transporter signature motif; other site 762376017974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376017975 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376017976 Walker A/P-loop; other site 762376017977 ATP binding site [chemical binding]; other site 762376017978 Q-loop/lid; other site 762376017979 ABC transporter signature motif; other site 762376017980 Walker B; other site 762376017981 D-loop; other site 762376017982 H-loop/switch region; other site 762376017983 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376017984 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376017985 Walker A/P-loop; other site 762376017986 ATP binding site [chemical binding]; other site 762376017987 Q-loop/lid; other site 762376017988 ABC transporter signature motif; other site 762376017989 Walker B; other site 762376017990 D-loop; other site 762376017991 H-loop/switch region; other site 762376017992 OsmC-like protein; Region: OsmC; cl00767 762376017993 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376017994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376017995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376017996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376017997 ligand binding site [chemical binding]; other site 762376017998 flexible hinge region; other site 762376017999 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762376018000 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376018001 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376018002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018003 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376018004 Walker A/P-loop; other site 762376018005 ATP binding site [chemical binding]; other site 762376018006 Q-loop/lid; other site 762376018007 ABC transporter signature motif; other site 762376018008 Walker B; other site 762376018009 D-loop; other site 762376018010 H-loop/switch region; other site 762376018011 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018012 TM-ABC transporter signature motif; other site 762376018013 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018014 TM-ABC transporter signature motif; other site 762376018015 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 762376018016 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376018017 putative ligand binding site [chemical binding]; other site 762376018018 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018019 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376018020 Walker A/P-loop; other site 762376018021 ATP binding site [chemical binding]; other site 762376018022 Q-loop/lid; other site 762376018023 ABC transporter signature motif; other site 762376018024 Walker B; other site 762376018025 D-loop; other site 762376018026 H-loop/switch region; other site 762376018027 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762376018028 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376018029 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 762376018030 YeeE/YedE family (DUF395); Region: DUF395; cl01018 762376018031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376018032 dimerization interface [polypeptide binding]; other site 762376018033 putative DNA binding site [nucleotide binding]; other site 762376018034 putative Zn2+ binding site [ion binding]; other site 762376018035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762376018036 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 762376018037 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 762376018038 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 762376018039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376018040 Coenzyme A binding pocket [chemical binding]; other site 762376018041 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 762376018042 nucleotide binding site/active site [active] 762376018043 HIT family signature motif; other site 762376018044 catalytic residue [active] 762376018045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376018046 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 762376018047 putative ADP-binding pocket [chemical binding]; other site 762376018048 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 762376018049 Protein of unknown function, DUF488; Region: DUF488; cl01246 762376018050 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 762376018051 classical (c) SDRs; Region: SDR_c; cd05233 762376018052 NAD(P) binding site [chemical binding]; other site 762376018053 active site 762376018054 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 762376018055 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376018056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376018057 N-terminal plug; other site 762376018058 ligand-binding site [chemical binding]; other site 762376018059 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376018060 FecR protein; Region: FecR; pfam04773 762376018061 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376018062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376018063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762376018064 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 762376018065 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 762376018066 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762376018067 ATP binding site [chemical binding]; other site 762376018068 Mg++ binding site [ion binding]; other site 762376018069 motif III; other site 762376018070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376018071 nucleotide binding region [chemical binding]; other site 762376018072 ATP-binding site [chemical binding]; other site 762376018073 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 762376018074 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13297 762376018075 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762376018076 active site 762376018077 NTP binding site [chemical binding]; other site 762376018078 metal binding triad [ion binding]; metal-binding site 762376018079 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762376018080 lytic murein transglycosylase; Provisional; Region: PRK11619 762376018081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376018082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376018083 catalytic residue [active] 762376018084 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 762376018085 Uncharacterized conserved protein [Function unknown]; Region: COG2308 762376018086 Domain of unknown function (DUF404); Region: DUF404; pfam04169 762376018087 Domain of unknown function (DUF407); Region: DUF407; pfam04174 762376018088 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 762376018089 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 762376018090 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 762376018091 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 762376018092 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765 762376018093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018097 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018098 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 762376018099 putative active site [active] 762376018100 putative catalytic site [active] 762376018101 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762376018102 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376018103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018105 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 762376018106 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 762376018107 FAD binding site [chemical binding]; other site 762376018108 Membrane protein of unknown function; Region: DUF360; cl00850 762376018109 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 762376018110 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 762376018111 oligomerization interface [polypeptide binding]; other site 762376018112 active site 762376018113 NAD+ binding site [chemical binding]; other site 762376018114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376018115 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 762376018116 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 762376018117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376018118 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 762376018119 substrate binding site [chemical binding]; other site 762376018120 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376018121 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 762376018122 substrate binding site [chemical binding]; other site 762376018123 ligand binding site [chemical binding]; other site 762376018124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018127 transcriptional activator TtdR; Provisional; Region: PRK09801 762376018128 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376018129 putative effector binding pocket; other site 762376018130 putative dimerization interface [polypeptide binding]; other site 762376018131 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376018132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018133 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376018134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018135 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376018136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018137 putative substrate translocation pore; other site 762376018138 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376018139 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376018140 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762376018141 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762376018142 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762376018143 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762376018144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376018145 putative acyl-acceptor binding pocket; other site 762376018146 Predicted acyltransferase [General function prediction only]; Region: COG4261 762376018147 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376018148 putative acyl-acceptor binding pocket; other site 762376018149 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 762376018150 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762376018151 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762376018152 Protein of unknown function, DUF484; Region: DUF484; cl01228 762376018153 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762376018154 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376018155 DNA binding site [nucleotide binding] 762376018156 Int/Topo IB signature motif; other site 762376018157 active site 762376018158 High-affinity nickel-transport protein; Region: NicO; cl00964 762376018159 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 762376018160 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 762376018161 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762376018162 metal binding site [ion binding]; metal-binding site 762376018163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762376018164 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762376018165 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 762376018166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376018167 metal binding site 2 [ion binding]; metal-binding site 762376018168 putative DNA binding helix; other site 762376018169 metal binding site 1 [ion binding]; metal-binding site 762376018170 dimer interface [polypeptide binding]; other site 762376018171 structural Zn2+ binding site [ion binding]; other site 762376018172 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376018173 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 762376018174 P-loop, Walker A motif; other site 762376018175 Base recognition motif; other site 762376018176 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 762376018177 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 762376018178 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 762376018179 active site 762376018180 HslU subunit interaction site [polypeptide binding]; other site 762376018181 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 762376018182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376018183 Walker A motif; other site 762376018184 ATP binding site [chemical binding]; other site 762376018185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376018186 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 762376018187 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 762376018188 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762376018189 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762376018190 NADP binding site [chemical binding]; other site 762376018191 active site 762376018192 putative substrate binding site [chemical binding]; other site 762376018193 Cupin domain; Region: Cupin_2; cl09118 762376018194 lipoyl synthase; Provisional; Region: PRK05481 762376018195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762376018196 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376018197 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 762376018198 Sel1 repeat; Region: Sel1; cl02723 762376018199 Sel1 repeat; Region: Sel1; cl02723 762376018200 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762376018201 Protein of unknown function (DUF493); Region: DUF493; cl01102 762376018202 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 762376018203 homodimer interface [polypeptide binding]; other site 762376018204 substrate-cofactor binding pocket; other site 762376018205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018206 Aminotransferase class IV; Region: Aminotran_4; pfam01063 762376018207 catalytic residue [active] 762376018208 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762376018209 Beta-lactamase; Region: Beta-lactamase; cl01009 762376018210 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 762376018211 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376018212 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376018213 conserved cys residue [active] 762376018214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376018215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376018216 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 762376018217 Protein of unknown function (DUF330); Region: DUF330; cl01135 762376018218 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 762376018219 mce related protein; Region: MCE; cl03606 762376018220 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762376018221 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 762376018222 Walker A/P-loop; other site 762376018223 ATP binding site [chemical binding]; other site 762376018224 Q-loop/lid; other site 762376018225 ABC transporter signature motif; other site 762376018226 Walker B; other site 762376018227 D-loop; other site 762376018228 H-loop/switch region; other site 762376018229 Domain of unknown function DUF140; Region: DUF140; cl00510 762376018230 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 762376018231 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762376018232 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762376018233 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 762376018234 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 762376018235 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 762376018236 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 762376018237 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376018238 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 762376018239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376018240 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 762376018241 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 762376018242 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376018243 putative trimer interface [polypeptide binding]; other site 762376018244 putative CoA binding site [chemical binding]; other site 762376018245 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762376018246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376018247 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 762376018248 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376018249 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 762376018250 putative trimer interface [polypeptide binding]; other site 762376018251 putative active site [active] 762376018252 putative substrate binding site [chemical binding]; other site 762376018253 putative CoA binding site [chemical binding]; other site 762376018254 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 762376018255 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 762376018256 inhibitor-cofactor binding pocket; inhibition site 762376018257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018258 catalytic residue [active] 762376018259 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 762376018260 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762376018261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376018262 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_III; cd01996 762376018263 Ligand Binding Site [chemical binding]; other site 762376018264 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 762376018265 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762376018266 putative active site [active] 762376018267 oxyanion strand; other site 762376018268 catalytic triad [active] 762376018269 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 762376018270 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 762376018271 substrate binding site [chemical binding]; other site 762376018272 glutamase interaction surface [polypeptide binding]; other site 762376018273 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 762376018274 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 762376018275 NAD(P) binding site [chemical binding]; other site 762376018276 homodimer interface [polypeptide binding]; other site 762376018277 substrate binding site [chemical binding]; other site 762376018278 active site 762376018279 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 762376018280 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 762376018281 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 762376018282 putative NAD(P) binding site [chemical binding]; other site 762376018283 active site 762376018284 putative substrate binding site [chemical binding]; other site 762376018285 Cupin domain; Region: Cupin_2; cl09118 762376018286 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 762376018287 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 762376018288 active site 762376018289 homodimer interface [polypeptide binding]; other site 762376018290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376018291 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762376018292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376018293 NAD(P) binding site [chemical binding]; other site 762376018294 active site 762376018295 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 762376018296 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854 762376018297 Mg++ binding site [ion binding]; other site 762376018298 putative catalytic motif [active] 762376018299 putative substrate binding site [chemical binding]; other site 762376018300 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 762376018301 putative trimer interface [polypeptide binding]; other site 762376018302 putative CoA binding site [chemical binding]; other site 762376018303 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 762376018304 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 762376018305 NAD(P) binding site [chemical binding]; other site 762376018306 homodimer interface [polypeptide binding]; other site 762376018307 substrate binding site [chemical binding]; other site 762376018308 active site 762376018309 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 762376018310 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 762376018311 NAD binding site [chemical binding]; other site 762376018312 substrate binding site [chemical binding]; other site 762376018313 homodimer interface [polypeptide binding]; other site 762376018314 active site 762376018315 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 762376018316 putative hydrophobic ligand binding site [chemical binding]; other site 762376018317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018318 putative substrate translocation pore; other site 762376018319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018320 EamA-like transporter family; Region: EamA; cl01037 762376018321 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376018322 EamA-like transporter family; Region: EamA; cl01037 762376018323 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 762376018324 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 762376018325 substrate binding site [chemical binding]; other site 762376018326 tetramer interface [polypeptide binding]; other site 762376018327 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376018328 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 762376018329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762376018330 S-adenosylmethionine binding site [chemical binding]; other site 762376018331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376018332 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762376018333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376018334 NAD(P) binding site [chemical binding]; other site 762376018335 active site 762376018336 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376018337 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376018338 Ligand binding site [chemical binding]; other site 762376018339 Putative Catalytic site [active] 762376018340 DXD motif; other site 762376018341 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 762376018342 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376018343 PYR/PP interface [polypeptide binding]; other site 762376018344 dimer interface [polypeptide binding]; other site 762376018345 TPP binding site [chemical binding]; other site 762376018346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376018347 TPP-binding site [chemical binding]; other site 762376018348 dimer interface [polypeptide binding]; other site 762376018349 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376018350 putative active site [active] 762376018351 catalytic site [active] 762376018352 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 762376018353 putative active site [active] 762376018354 catalytic site [active] 762376018355 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762376018356 putative catalytic site [active] 762376018357 putative metal binding site [ion binding]; other site 762376018358 putative phosphate binding site [ion binding]; other site 762376018359 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762376018360 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762376018361 dimer interface [polypeptide binding]; other site 762376018362 anticodon binding site; other site 762376018363 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 762376018364 homodimer interface [polypeptide binding]; other site 762376018365 motif 1; other site 762376018366 active site 762376018367 motif 2; other site 762376018368 GAD domain; Region: GAD; pfam02938 762376018369 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 762376018370 motif 3; other site 762376018371 Protein of unknown function (DUF502); Region: DUF502; cl01107 762376018372 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 762376018373 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 762376018374 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376018375 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376018376 MlrC C-terminus; Region: MlrC_C; pfam07171 762376018377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018379 hypothetical protein; Provisional; Region: PRK07483 762376018380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762376018381 inhibitor-cofactor binding pocket; inhibition site 762376018382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018383 catalytic residue [active] 762376018384 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376018385 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762376018386 putative active site [active] 762376018387 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 762376018388 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 762376018389 dimer interface [polypeptide binding]; other site 762376018390 active site 762376018391 Fatty acid desaturase; Region: FA_desaturase; pfam00487 762376018392 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 762376018393 putative di-iron ligands [ion binding]; other site 762376018394 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 762376018395 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376018396 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762376018397 dimer interface [polypeptide binding]; other site 762376018398 active site 762376018399 catalytic residue [active] 762376018400 GAF domain; Region: GAF; cl00853 762376018401 aspartate aminotransferase; Provisional; Region: PRK08361 762376018402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376018403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018404 homodimer interface [polypeptide binding]; other site 762376018405 catalytic residue [active] 762376018406 UbiA prenyltransferase family; Region: UbiA; cl00337 762376018407 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 762376018408 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 762376018409 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762376018410 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 762376018411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018412 DNA-binding site [nucleotide binding]; DNA binding site 762376018413 FCD domain; Region: FCD; cl11656 762376018414 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 762376018415 active site 762376018416 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376018417 catalytic triad [active] 762376018418 conserved cis-peptide bond; other site 762376018419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376018420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376018421 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 762376018422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376018423 Walker A motif; other site 762376018424 ATP binding site [chemical binding]; other site 762376018425 Walker B motif; other site 762376018426 arginine finger; other site 762376018427 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762376018428 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 762376018429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376018430 ATP binding site [chemical binding]; other site 762376018431 putative Mg++ binding site [ion binding]; other site 762376018432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376018433 nucleotide binding region [chemical binding]; other site 762376018434 ATP-binding site [chemical binding]; other site 762376018435 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 762376018436 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762376018437 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762376018438 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762376018439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376018440 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 762376018441 Domain of unknown function (DUF955); Region: DUF955; cl01076 762376018442 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 762376018443 active site 762376018444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 762376018445 Phage integrase family; Region: Phage_integrase; pfam00589 762376018446 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 762376018447 DNA binding site [nucleotide binding] 762376018448 Int/Topo IB signature motif; other site 762376018449 active site 762376018450 catalytic residues [active] 762376018451 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376018452 Int/Topo IB signature motif; other site 762376018453 active site 762376018454 DNA binding site [nucleotide binding] 762376018455 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376018456 dimer interface [polypeptide binding]; other site 762376018457 ssDNA binding site [nucleotide binding]; other site 762376018458 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376018459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018460 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762376018461 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762376018462 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762376018463 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 762376018464 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 762376018465 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376018466 putative C-terminal domain interface [polypeptide binding]; other site 762376018467 putative GSH binding site (G-site) [chemical binding]; other site 762376018468 putative dimer interface [polypeptide binding]; other site 762376018469 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 762376018470 putative N-terminal domain interface [polypeptide binding]; other site 762376018471 putative dimer interface [polypeptide binding]; other site 762376018472 putative substrate binding pocket (H-site) [chemical binding]; other site 762376018473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376018476 dimerization interface [polypeptide binding]; other site 762376018477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018479 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376018480 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376018481 metal binding site [ion binding]; metal-binding site 762376018482 putative dimer interface [polypeptide binding]; other site 762376018483 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 762376018484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376018485 Zn2+ binding site [ion binding]; other site 762376018486 Mg2+ binding site [ion binding]; other site 762376018487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376018488 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762376018489 active site 762376018490 dimer interface [polypeptide binding]; other site 762376018491 metal binding site [ion binding]; metal-binding site 762376018492 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 762376018493 shikimate kinase; Reviewed; Region: aroK; PRK00131 762376018494 ADP binding site [chemical binding]; other site 762376018495 magnesium binding site [ion binding]; other site 762376018496 putative shikimate binding site; other site 762376018497 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 762376018498 Transglycosylase; Region: Transgly; cl07896 762376018499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762376018500 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 762376018501 putative iron binding site [ion binding]; other site 762376018502 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762376018503 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762376018504 active site 762376018505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376018506 substrate binding site [chemical binding]; other site 762376018507 catalytic residues [active] 762376018508 dimer interface [polypeptide binding]; other site 762376018509 PEGA domain; Region: PEGA; pfam08308 762376018510 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 762376018511 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 762376018512 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 762376018513 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 762376018514 hypothetical protein; Provisional; Region: PRK07033 762376018515 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 762376018516 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376018517 ligand binding site [chemical binding]; other site 762376018518 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 762376018519 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 762376018520 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762376018521 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 762376018522 phosphopeptide binding site; other site 762376018523 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 762376018524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376018525 Walker A motif; other site 762376018526 ATP binding site [chemical binding]; other site 762376018527 Walker B motif; other site 762376018528 arginine finger; other site 762376018529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376018530 Walker A motif; other site 762376018531 ATP binding site [chemical binding]; other site 762376018532 Walker B motif; other site 762376018533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376018534 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 762376018535 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 762376018536 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 762376018537 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 762376018538 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 762376018539 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 762376018540 ImpE protein; Region: ImpE; pfam07024 762376018541 Protein of unknown function (DUF796); Region: DUF796; cl01226 762376018542 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 762376018543 Protein of unknown function (DUF877); Region: DUF877; pfam05943 762376018544 Protein of unknown function (DUF770); Region: DUF770; cl01402 762376018545 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 762376018546 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 762376018547 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 762376018548 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 762376018549 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 762376018550 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376018551 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 762376018552 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 762376018553 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376018554 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018557 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018558 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376018559 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376018560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376018562 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376018563 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 762376018564 ResB-like family; Region: ResB; pfam05140 762376018565 Cytochrome c; Region: Cytochrom_C; cl11414 762376018566 Cytochrome c; Region: Cytochrom_C; cl11414 762376018567 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 762376018568 G1 box; other site 762376018569 GTP/Mg2+ binding site [chemical binding]; other site 762376018570 Switch I region; other site 762376018571 G2 box; other site 762376018572 G3 box; other site 762376018573 Switch II region; other site 762376018574 G4 box; other site 762376018575 G5 box; other site 762376018576 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 762376018577 dimer interface [polypeptide binding]; other site 762376018578 active site 762376018579 aspartate-rich active site metal binding site; other site 762376018580 allosteric magnesium binding site [ion binding]; other site 762376018581 Schiff base residues; other site 762376018582 EamA-like transporter family; Region: EamA; cl01037 762376018583 EamA-like transporter family; Region: EamA; cl01037 762376018584 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018585 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376018586 Walker A/P-loop; other site 762376018587 ATP binding site [chemical binding]; other site 762376018588 Q-loop/lid; other site 762376018589 ABC transporter signature motif; other site 762376018590 Walker B; other site 762376018591 D-loop; other site 762376018592 H-loop/switch region; other site 762376018593 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018594 TM-ABC transporter signature motif; other site 762376018595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018596 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376018597 Walker A/P-loop; other site 762376018598 ATP binding site [chemical binding]; other site 762376018599 Q-loop/lid; other site 762376018600 ABC transporter signature motif; other site 762376018601 Walker B; other site 762376018602 D-loop; other site 762376018603 H-loop/switch region; other site 762376018604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018605 TM-ABC transporter signature motif; other site 762376018606 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376018607 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376018608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376018609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376018610 NAD(P) binding site [chemical binding]; other site 762376018611 active site 762376018612 putative succinate dehydrogenase; Reviewed; Region: PRK12842 762376018613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376018614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018616 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018617 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 762376018618 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 762376018619 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 762376018620 DsbD alpha interface [polypeptide binding]; other site 762376018621 catalytic residues [active] 762376018622 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 762376018623 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 762376018624 nucleotide binding site/active site [active] 762376018625 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 762376018626 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762376018627 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762376018628 alphaNTD homodimer interface [polypeptide binding]; other site 762376018629 alphaNTD - beta interaction site [polypeptide binding]; other site 762376018630 alphaNTD - beta' interaction site [polypeptide binding]; other site 762376018631 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 762376018632 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762376018633 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762376018634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376018635 RNA binding surface [nucleotide binding]; other site 762376018636 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 762376018637 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 762376018638 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 762376018639 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 762376018640 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762376018641 rRNA binding site [nucleotide binding]; other site 762376018642 predicted 30S ribosome binding site; other site 762376018643 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762376018644 SecY translocase; Region: SecY; pfam00344 762376018645 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 762376018646 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 762376018647 23S rRNA binding site [nucleotide binding]; other site 762376018648 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762376018649 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762376018650 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762376018651 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762376018652 5S rRNA interface [nucleotide binding]; other site 762376018653 L27 interface [polypeptide binding]; other site 762376018654 23S rRNA interface [nucleotide binding]; other site 762376018655 L5 interface [polypeptide binding]; other site 762376018656 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762376018657 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762376018658 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762376018659 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 762376018660 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 762376018661 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762376018662 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762376018663 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762376018664 KOW motif; Region: KOW; cl00354 762376018665 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 762376018666 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 762376018667 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376018668 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376018669 tetramerization interface [polypeptide binding]; other site 762376018670 NAD(P) binding site [chemical binding]; other site 762376018671 catalytic residues [active] 762376018672 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376018673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376018674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376018675 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376018676 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 762376018677 putative ligand binding site [chemical binding]; other site 762376018678 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018679 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376018680 Walker A/P-loop; other site 762376018681 ATP binding site [chemical binding]; other site 762376018682 Q-loop/lid; other site 762376018683 ABC transporter signature motif; other site 762376018684 Walker B; other site 762376018685 D-loop; other site 762376018686 H-loop/switch region; other site 762376018687 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018688 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376018689 Walker A/P-loop; other site 762376018690 ATP binding site [chemical binding]; other site 762376018691 Q-loop/lid; other site 762376018692 ABC transporter signature motif; other site 762376018693 Walker B; other site 762376018694 D-loop; other site 762376018695 H-loop/switch region; other site 762376018696 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018697 TM-ABC transporter signature motif; other site 762376018698 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018699 TM-ABC transporter signature motif; other site 762376018700 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 762376018701 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 762376018702 23S rRNA interface [nucleotide binding]; other site 762376018703 putative translocon interaction site; other site 762376018704 signal recognition particle (SRP54) interaction site; other site 762376018705 L23 interface [polypeptide binding]; other site 762376018706 trigger factor interaction site; other site 762376018707 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762376018708 23S rRNA interface [nucleotide binding]; other site 762376018709 5S rRNA interface [nucleotide binding]; other site 762376018710 putative antibiotic binding site [chemical binding]; other site 762376018711 L25 interface [polypeptide binding]; other site 762376018712 L27 interface [polypeptide binding]; other site 762376018713 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762376018714 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 762376018715 G-X-X-G motif; other site 762376018716 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762376018717 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762376018718 putative translocon binding site; other site 762376018719 protein-rRNA interface [nucleotide binding]; other site 762376018720 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 762376018721 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762376018722 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762376018723 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762376018724 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 762376018725 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 762376018726 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 762376018727 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 762376018728 elongation factor Tu; Reviewed; Region: PRK00049 762376018729 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 762376018730 G1 box; other site 762376018731 GEF interaction site [polypeptide binding]; other site 762376018732 GTP/Mg2+ binding site [chemical binding]; other site 762376018733 Switch I region; other site 762376018734 G2 box; other site 762376018735 G3 box; other site 762376018736 Switch II region; other site 762376018737 G4 box; other site 762376018738 G5 box; other site 762376018739 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762376018740 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 762376018741 Antibiotic Binding Site [chemical binding]; other site 762376018742 elongation factor G; Reviewed; Region: PRK00007 762376018743 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 762376018744 G1 box; other site 762376018745 putative GEF interaction site [polypeptide binding]; other site 762376018746 GTP/Mg2+ binding site [chemical binding]; other site 762376018747 Switch I region; other site 762376018748 G2 box; other site 762376018749 G3 box; other site 762376018750 Switch II region; other site 762376018751 G4 box; other site 762376018752 G5 box; other site 762376018753 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 762376018754 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 762376018755 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 762376018756 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 762376018757 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762376018758 S17 interaction site [polypeptide binding]; other site 762376018759 S8 interaction site; other site 762376018760 16S rRNA interaction site [nucleotide binding]; other site 762376018761 streptomycin interaction site [chemical binding]; other site 762376018762 23S rRNA interaction site [nucleotide binding]; other site 762376018763 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762376018764 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 762376018765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376018766 DNA binding site [nucleotide binding] 762376018767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376018768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376018769 active site 762376018770 phosphorylation site [posttranslational modification] 762376018771 intermolecular recognition site; other site 762376018772 dimerization interface [polypeptide binding]; other site 762376018773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376018774 DNA binding site [nucleotide binding] 762376018775 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762376018776 putative peptidoglycan binding site; other site 762376018777 FecR protein; Region: FecR; pfam04773 762376018778 CHASE2 domain; Region: CHASE2; cl01732 762376018779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762376018780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376018781 dimer interface [polypeptide binding]; other site 762376018782 phosphorylation site [posttranslational modification] 762376018783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018784 ATP binding site [chemical binding]; other site 762376018785 Mg2+ binding site [ion binding]; other site 762376018786 G-X-G motif; other site 762376018787 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 762376018788 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762376018789 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 762376018790 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762376018791 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 762376018792 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762376018793 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762376018794 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 762376018795 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 762376018796 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762376018797 DNA binding site [nucleotide binding] 762376018798 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762376018799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 762376018800 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 762376018801 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 762376018802 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762376018803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 762376018804 RPB11 interaction site [polypeptide binding]; other site 762376018805 RPB12 interaction site [polypeptide binding]; other site 762376018806 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762376018807 RPB3 interaction site [polypeptide binding]; other site 762376018808 RPB1 interaction site [polypeptide binding]; other site 762376018809 RPB11 interaction site [polypeptide binding]; other site 762376018810 RPB10 interaction site [polypeptide binding]; other site 762376018811 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762376018812 core dimer interface [polypeptide binding]; other site 762376018813 peripheral dimer interface [polypeptide binding]; other site 762376018814 L10 interface [polypeptide binding]; other site 762376018815 L11 interface [polypeptide binding]; other site 762376018816 putative EF-Tu interaction site [polypeptide binding]; other site 762376018817 putative EF-G interaction site [polypeptide binding]; other site 762376018818 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 762376018819 23S rRNA interface [nucleotide binding]; other site 762376018820 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762376018821 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 762376018822 mRNA/rRNA interface [nucleotide binding]; other site 762376018823 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762376018824 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762376018825 23S rRNA interface [nucleotide binding]; other site 762376018826 L7/L12 interface [polypeptide binding]; other site 762376018827 putative thiostrepton binding site; other site 762376018828 L25 interface [polypeptide binding]; other site 762376018829 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762376018830 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762376018831 putative homodimer interface [polypeptide binding]; other site 762376018832 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 762376018833 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 762376018834 elongation factor Tu; Reviewed; Region: PRK00049 762376018835 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 762376018836 G1 box; other site 762376018837 GEF interaction site [polypeptide binding]; other site 762376018838 GTP/Mg2+ binding site [chemical binding]; other site 762376018839 Switch I region; other site 762376018840 G2 box; other site 762376018841 G3 box; other site 762376018842 Switch II region; other site 762376018843 G4 box; other site 762376018844 G5 box; other site 762376018845 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762376018846 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 762376018847 Antibiotic Binding Site [chemical binding]; other site 762376018848 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376018849 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 762376018850 putative active site [active] 762376018851 metal binding site [ion binding]; metal-binding site 762376018852 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376018853 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 762376018854 NAD(P) binding site [chemical binding]; other site 762376018855 catalytic residues [active] 762376018856 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 762376018857 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762376018858 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 762376018859 active site 762376018860 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 762376018861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018862 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 762376018863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376018864 Walker A/P-loop; other site 762376018865 ATP binding site [chemical binding]; other site 762376018866 Q-loop/lid; other site 762376018867 ABC transporter signature motif; other site 762376018868 Walker B; other site 762376018869 D-loop; other site 762376018870 H-loop/switch region; other site 762376018871 TOBE domain; Region: TOBE_2; cl01440 762376018872 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 762376018873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376018874 dimer interface [polypeptide binding]; other site 762376018875 conserved gate region; other site 762376018876 putative PBP binding loops; other site 762376018877 ABC-ATPase subunit interface; other site 762376018878 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762376018879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018880 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 762376018881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018883 cystathionine beta-lyase; Provisional; Region: PRK09028 762376018884 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376018885 homodimer interface [polypeptide binding]; other site 762376018886 substrate-cofactor binding pocket; other site 762376018887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018888 catalytic residue [active] 762376018889 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762376018890 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376018891 active site residue [active] 762376018892 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative...; Region: 4RHOD_Repeat_2; cd01533 762376018893 active site residue [active] 762376018894 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 762376018895 active site residue [active] 762376018896 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376018897 active site residue [active] 762376018898 Cysteine dioxygenase type I; Region: CDO_I; cl02350 762376018899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376018901 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 762376018902 putative dimerization interface [polypeptide binding]; other site 762376018903 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 762376018904 active site/substrate binding site [active] 762376018905 tetramer interface [polypeptide binding]; other site 762376018906 ParB-like partition proteins; Region: parB_part; TIGR00180 762376018907 ParB-like nuclease domain; Region: ParBc; cl02129 762376018908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376018909 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762376018910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376018911 P-loop; other site 762376018912 Magnesium ion binding site [ion binding]; other site 762376018913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376018914 Magnesium ion binding site [ion binding]; other site 762376018915 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 762376018916 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 762376018917 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 762376018918 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762376018919 DNA-binding site [nucleotide binding]; DNA binding site 762376018920 RNA-binding motif; other site 762376018921 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 762376018922 Putative ammonia monooxygenase; Region: AmoA; pfam05145 762376018923 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 762376018924 methionine aminotransferase; Validated; Region: PRK09082 762376018925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376018926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018927 homodimer interface [polypeptide binding]; other site 762376018928 catalytic residue [active] 762376018929 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376018930 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376018931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018933 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376018934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762376018935 dimer interface [polypeptide binding]; other site 762376018936 phosphorylation site [posttranslational modification] 762376018937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018938 ATP binding site [chemical binding]; other site 762376018939 Mg2+ binding site [ion binding]; other site 762376018940 G-X-G motif; other site 762376018941 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376018942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762376018943 active site 762376018944 phosphorylation site [posttranslational modification] 762376018945 intermolecular recognition site; other site 762376018946 dimerization interface [polypeptide binding]; other site 762376018947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762376018948 DNA binding site [nucleotide binding] 762376018949 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 762376018950 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 762376018951 Cl- selectivity filter; other site 762376018952 Cl- binding residues [ion binding]; other site 762376018953 pore gating glutamate residue; other site 762376018954 dimer interface [polypeptide binding]; other site 762376018955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376018956 Coenzyme A binding pocket [chemical binding]; other site 762376018957 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 762376018958 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 762376018959 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 762376018960 G1 box; other site 762376018961 GTP/Mg2+ binding site [chemical binding]; other site 762376018962 Switch I region; other site 762376018963 G2 box; other site 762376018964 Switch II region; other site 762376018965 G3 box; other site 762376018966 G4 box; other site 762376018967 G5 box; other site 762376018968 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 762376018969 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376018970 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376018971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376018972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376018973 dimer interface [polypeptide binding]; other site 762376018974 conserved gate region; other site 762376018975 putative PBP binding loops; other site 762376018976 ABC-ATPase subunit interface; other site 762376018977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376018978 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762376018979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762376018980 dimer interface [polypeptide binding]; other site 762376018981 conserved gate region; other site 762376018982 putative PBP binding loops; other site 762376018983 ABC-ATPase subunit interface; other site 762376018984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376018985 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376018986 Walker A/P-loop; other site 762376018987 ATP binding site [chemical binding]; other site 762376018988 Q-loop/lid; other site 762376018989 ABC transporter signature motif; other site 762376018990 Walker B; other site 762376018991 D-loop; other site 762376018992 H-loop/switch region; other site 762376018993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376018994 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376018995 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762376018996 Walker A/P-loop; other site 762376018997 ATP binding site [chemical binding]; other site 762376018998 Q-loop/lid; other site 762376018999 ABC transporter signature motif; other site 762376019000 Walker B; other site 762376019001 D-loop; other site 762376019002 H-loop/switch region; other site 762376019003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376019004 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376019005 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376019006 metal binding site [ion binding]; metal-binding site 762376019007 putative dimer interface [polypeptide binding]; other site 762376019008 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376019009 homotrimer interaction site [polypeptide binding]; other site 762376019010 putative active site [active] 762376019011 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376019012 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 762376019013 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376019014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019015 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376019017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376019018 DNA-binding site [nucleotide binding]; DNA binding site 762376019019 FCD domain; Region: FCD; cl11656 762376019020 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376019021 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 762376019022 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376019023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019024 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376019025 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 762376019026 Walker A/P-loop; other site 762376019027 ATP binding site [chemical binding]; other site 762376019028 Q-loop/lid; other site 762376019029 ABC transporter signature motif; other site 762376019030 Walker B; other site 762376019031 D-loop; other site 762376019032 H-loop/switch region; other site 762376019033 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376019034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762376019035 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762376019036 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762376019037 tetramer interface [polypeptide binding]; other site 762376019038 heme binding pocket [chemical binding]; other site 762376019039 NADPH binding site [chemical binding]; other site 762376019040 membrane protein insertase; Provisional; Region: PRK01318 762376019041 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 762376019042 Domain of unknown function DUF37; Region: DUF37; cl00506 762376019043 Ribonuclease P; Region: Ribonuclease_P; cl00457 762376019044 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 762376019045 Replication initiator protein A; Region: RPA; cl02339 762376019046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376019047 dimer interface [polypeptide binding]; other site 762376019048 ssDNA binding site [nucleotide binding]; other site 762376019049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376019050 conjugal transfer protein TrbA; Provisional; Region: PRK13890 762376019051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376019052 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 762376019053 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 762376019054 ATP binding site [chemical binding]; other site 762376019055 Walker A motif; other site 762376019056 hexamer interface [polypeptide binding]; other site 762376019057 Walker B motif; other site 762376019058 TrbC/VIRB2 family; Region: TrbC; cl01583 762376019059 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 762376019060 conjugal transfer protein TrbE; Provisional; Region: PRK13891 762376019061 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 762376019062 VirB8 protein; Region: VirB8; cl01500 762376019063 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 762376019064 VirB7 interaction site; other site 762376019065 conjugal transfer protein TrbH; Provisional; Region: PRK13883 762376019066 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 762376019067 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 762376019068 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 762376019069 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 762376019070 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 762376019071 TrbM; Region: TrbM; cl06455 762376019072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 762376019073 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376019074 catalytic residue [active] 762376019075 TraX protein; Region: TraX; cl05434 762376019076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 762376019077 ligand binding site [chemical binding]; other site 762376019078 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 762376019079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 762376019080 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376019081 DNA binding residues [nucleotide binding] 762376019082 Integrase core domain; Region: rve; cl01316 762376019083 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 762376019084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376019085 Walker A motif; other site 762376019086 ATP binding site [chemical binding]; other site 762376019087 Walker B motif; other site 762376019088 arginine finger; other site 762376019089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376019090 H-loop/switch region; other site 762376019091 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376019092 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376019093 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 762376019094 active site 762376019095 dimer interface [polypeptide binding]; other site 762376019096 metal binding site [ion binding]; metal-binding site 762376019097 Dienelactone hydrolase family; Region: DLH; pfam01738 762376019098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019100 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-...; Region: MLE; cd03318 762376019101 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 762376019102 octamer interface [polypeptide binding]; other site 762376019103 active site 762376019104 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is...; Region: 1,2-CCD; cd03462 762376019105 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 762376019106 dimer interface [polypeptide binding]; other site 762376019107 active site 762376019108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019109 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376019110 The C-terminal substrate binding domain of LysR-type transcriptional regulator, CbnR, involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_CbnR; cd08486 762376019111 dimerization interface [polypeptide binding]; other site 762376019112 putative substrate binding pocket [chemical binding]; other site 762376019113 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376019114 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376019115 YCII-related domain; Region: YCII; cl00999 762376019116 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 762376019117 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 762376019118 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 762376019119 putative active site [active] 762376019120 putative metal binding site [ion binding]; other site 762376019121 NIPSNAP; Region: NIPSNAP; pfam07978 762376019122 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376019123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019124 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376019125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376019127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019128 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376019129 substrate binding pocket [chemical binding]; other site 762376019130 dimerization interface [polypeptide binding]; other site 762376019131 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376019132 Q-loop/lid; other site 762376019133 ABC transporter signature motif; other site 762376019134 Walker B; other site 762376019135 D-loop; other site 762376019136 H-loop/switch region; other site 762376019137 Transposase domain (DUF772); Region: DUF772; cl12084 762376019138 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376019139 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376019140 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376019141 Walker A/P-loop; other site 762376019142 ATP binding site [chemical binding]; other site 762376019143 Q-loop/lid; other site 762376019144 ABC transporter signature motif; other site 762376019145 Walker B; other site 762376019146 D-loop; other site 762376019147 H-loop/switch region; other site 762376019148 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376019149 TM-ABC transporter signature motif; other site 762376019150 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376019151 TM-ABC transporter signature motif; other site 762376019152 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 762376019153 [2Fe-2S] cluster binding site [ion binding]; other site 762376019154 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376019155 Transposase domain (DUF772); Region: DUF772; cl12084 762376019156 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376019157 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376019158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376019159 This alignment model represents the N-terminal rieske iron-sulfur domain of the oxygenase alpha subunit (NagG) of salicylate 5-hydroxylase (S5H). S5H converts salicylate (2-hydroxybenzoate), a metabolic intermediate of phenanthrene, to gentisate (2,5-...; Region: Rieske_RO_Alpha_S5H; cd03539 762376019160 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376019161 putative alpha subunit interface [polypeptide binding]; other site 762376019162 putative active site [active] 762376019163 putative substrate binding site [chemical binding]; other site 762376019164 Fe binding site [ion binding]; other site 762376019165 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376019166 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376019167 catalytic loop [active] 762376019168 iron binding site [ion binding]; other site 762376019169 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 762376019170 FAD binding pocket [chemical binding]; other site 762376019171 FAD binding motif [chemical binding]; other site 762376019172 phosphate binding motif [ion binding]; other site 762376019173 beta-alpha-beta structure motif; other site 762376019174 NAD binding pocket [chemical binding]; other site 762376019175 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 762376019176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019177 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376019178 substrate binding pocket [chemical binding]; other site 762376019179 dimerization interface [polypeptide binding]; other site 762376019180 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376019181 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376019182 putative ligand binding site [chemical binding]; other site 762376019183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019184 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376019185 inter-subunit interface; other site 762376019186 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H)...; Region: Rieske_RO_Alpha_OHBDO_like; cd03545 762376019187 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376019188 putative alpha subunit interface [polypeptide binding]; other site 762376019189 putative active site [active] 762376019190 putative substrate binding site [chemical binding]; other site 762376019191 Fe binding site [ion binding]; other site 762376019192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 762376019193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376019194 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376019195 Walker A motif; other site 762376019196 ATP binding site [chemical binding]; other site 762376019197 Walker B motif; other site 762376019198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 762376019199 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762376019200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 762376019201 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376019202 DNA binding residues [nucleotide binding] 762376019203 Integrase core domain; Region: rve; cl01316 762376019204 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 762376019205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376019206 Walker A motif; other site 762376019207 ATP binding site [chemical binding]; other site 762376019208 Walker B motif; other site 762376019209 arginine finger; other site 762376019210 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 762376019211 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 762376019212 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 762376019213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 762376019214 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029 762376019215 active site 762376019216 metal binding site [ion binding]; metal-binding site 762376019217 interdomain interaction site; other site 762376019218 DNA topoisomerase III; Provisional; Region: PRK07726 762376019219 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376019220 active site 762376019221 putative interdomain interaction site [polypeptide binding]; other site 762376019222 putative metal-binding site [ion binding]; other site 762376019223 putative nucleotide binding site [chemical binding]; other site 762376019224 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 762376019225 domain I; other site 762376019226 DNA binding groove [nucleotide binding] 762376019227 phosphate binding site [ion binding]; other site 762376019228 domain II; other site 762376019229 domain III; other site 762376019230 nucleotide binding site [chemical binding]; other site 762376019231 catalytic site [active] 762376019232 domain IV; other site 762376019233 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 762376019234 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 762376019235 Peptidase S26; Region: Peptidase_S26; pfam10502 762376019236 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 762376019237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376019238 Walker A motif; other site 762376019239 ATP binding site [chemical binding]; other site 762376019240 Walker B motif; other site 762376019241 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 762376019242 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 762376019243 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 762376019244 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 762376019245 P-loop; other site 762376019246 Transcriptional activator TraM; Region: Activator-TraM; cl11943 762376019247 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 762376019248 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376019249 ParB-like partition proteins; Region: parB_part; TIGR00180 762376019250 ParB-like nuclease domain; Region: ParBc; cl02129 762376019251 KorB domain; Region: KorB; pfam08535 762376019252 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 762376019253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376019254 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 762376019255 P-loop; other site 762376019256 Magnesium ion binding site [ion binding]; other site 762376019257 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376019258 Magnesium ion binding site [ion binding]; other site 762376019259 conjugal transfer protein TrbA; Provisional; Region: PRK13890 762376019260 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959 762376019261 Antirestriction protein; Region: Antirestrict; pfam03230 762376019262 RelB antitoxin; Region: RelB; cl01171 762376019263 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 762376019264 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376019265 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 762376019266 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 762376019267 Int/Topo IB signature motif; other site 762376019268 Glycerate kinase family; Region: Gly_kinase; cl00841 762376019269 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 762376019270 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762376019271 active site 762376019272 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376019273 metal-binding site [ion binding] 762376019274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762376019275 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376019276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762376019277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376019278 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 762376019279 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 762376019280 DNA binding residues [nucleotide binding] 762376019281 dimer interface [polypeptide binding]; other site 762376019282 putative metal binding site [ion binding]; other site 762376019283 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 762376019284 Cation efflux family; Region: Cation_efflux; cl00316 762376019285 Cytochrome c; Region: Cytochrom_C; cl11414 762376019286 Iron permease FTR1 family; Region: FTR1; cl00475 762376019287 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 762376019288 Initiator Replication protein; Region: Rep_3; cl03080 762376019289 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376019290 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762376019291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376019292 active site 762376019293 Int/Topo IB signature motif; other site 762376019294 DNA binding site [nucleotide binding] 762376019295 thiolase; Provisional; Region: PRK06158 762376019296 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376019297 active site 762376019298 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 762376019299 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376019300 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376019301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019303 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376019304 active site 762376019305 catalytic site [active] 762376019306 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376019307 active site 762376019308 catalytic site [active] 762376019309 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376019310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019311 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019312 Integrase core domain; Region: rve; cl01316 762376019313 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376019314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019315 substrate binding site [chemical binding]; other site 762376019316 oxyanion hole (OAH) forming residues; other site 762376019317 trimer interface [polypeptide binding]; other site 762376019318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019319 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019320 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019322 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019323 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019324 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376019325 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376019326 active site 762376019327 FMN binding site [chemical binding]; other site 762376019328 substrate binding site [chemical binding]; other site 762376019329 homotetramer interface [polypeptide binding]; other site 762376019330 catalytic residue [active] 762376019331 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 762376019332 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376019333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019334 NAD(P) binding site [chemical binding]; other site 762376019335 active site 762376019336 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376019337 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 762376019338 Walker A/P-loop; other site 762376019339 ATP binding site [chemical binding]; other site 762376019340 Q-loop/lid; other site 762376019341 ABC transporter signature motif; other site 762376019342 Walker B; other site 762376019343 D-loop; other site 762376019344 H-loop/switch region; other site 762376019345 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376019346 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 762376019347 Walker A/P-loop; other site 762376019348 ATP binding site [chemical binding]; other site 762376019349 Q-loop/lid; other site 762376019350 ABC transporter signature motif; other site 762376019351 Walker B; other site 762376019352 D-loop; other site 762376019353 H-loop/switch region; other site 762376019354 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376019355 TM-ABC transporter signature motif; other site 762376019356 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376019357 TM-ABC transporter signature motif; other site 762376019358 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376019359 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 762376019360 putative ligand binding site [chemical binding]; other site 762376019361 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376019362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019363 enoyl-CoA hydratase; Provisional; Region: PRK07327 762376019364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019365 substrate binding site [chemical binding]; other site 762376019366 oxyanion hole (OAH) forming residues; other site 762376019367 trimer interface [polypeptide binding]; other site 762376019368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376019369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019371 dimerization interface [polypeptide binding]; other site 762376019372 Coenzyme A transferase; Region: CoA_trans; cl00773 762376019373 Coenzyme A transferase; Region: CoA_trans; cl00773 762376019374 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762376019375 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376019376 CoenzymeA binding site [chemical binding]; other site 762376019377 subunit interaction site [polypeptide binding]; other site 762376019378 PHB binding site; other site 762376019379 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376019380 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019382 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019383 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 762376019384 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376019385 NADP binding site [chemical binding]; other site 762376019386 dimer interface [polypeptide binding]; other site 762376019387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019389 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376019390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019391 NAD(P) binding site [chemical binding]; other site 762376019392 active site 762376019393 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376019394 active site 2 [active] 762376019395 active site 1 [active] 762376019396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376019397 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376019398 active site 762376019399 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376019400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019403 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 762376019404 substrate binding site [chemical binding]; other site 762376019405 oxyanion hole (OAH) forming residues; other site 762376019406 trimer interface [polypeptide binding]; other site 762376019407 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 762376019408 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 762376019409 active site 762376019410 FMN binding site [chemical binding]; other site 762376019411 2,4-decadienoyl-CoA binding site; other site 762376019412 catalytic residue [active] 762376019413 4Fe-4S cluster binding site [ion binding]; other site 762376019414 enoyl-CoA hydratase; Provisional; Region: PRK07327 762376019415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019416 substrate binding site [chemical binding]; other site 762376019417 oxyanion hole (OAH) forming residues; other site 762376019418 trimer interface [polypeptide binding]; other site 762376019419 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376019420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019421 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376019422 Ligand binding site [chemical binding]; other site 762376019423 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 762376019424 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376019425 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376019426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019427 substrate binding site [chemical binding]; other site 762376019428 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376019429 oxyanion hole (OAH) forming residues; other site 762376019430 trimer interface [polypeptide binding]; other site 762376019431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376019433 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 762376019434 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376019435 dimer interface [polypeptide binding]; other site 762376019436 active site 762376019437 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376019438 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376019439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376019440 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376019441 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762376019442 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762376019443 carboxyltransferase (CT) interaction site; other site 762376019444 biotinylation site [posttranslational modification]; other site 762376019445 enoyl-CoA hydratase; Provisional; Region: PRK05995 762376019446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762376019447 substrate binding site [chemical binding]; other site 762376019448 oxyanion hole (OAH) forming residues; other site 762376019449 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376019450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376019451 active site 762376019452 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 762376019453 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762376019454 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376019455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019456 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762376019457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019459 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376019460 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376019461 thiolase; Provisional; Region: PRK06158 762376019462 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376019463 active site 762376019464 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376019465 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376019466 active site 762376019467 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376019468 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376019469 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376019470 active site 762376019471 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376019472 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762376019473 FMN binding site [chemical binding]; other site 762376019474 substrate binding site [chemical binding]; other site 762376019475 putative catalytic residue [active] 762376019476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019478 CoA-transferase family III; Region: CoA_transf_3; cl00778 762376019479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019480 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376019481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376019482 putative substrate translocation pore; other site 762376019483 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376019484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376019486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376019487 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376019488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019489 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376019490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762376019491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019492 dimerization interface [polypeptide binding]; other site 762376019493 putative succinate dehydrogenase; Reviewed; Region: PRK12842 762376019494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762376019495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376019496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376019497 active site 762376019498 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376019499 active site 2 [active] 762376019500 active site 1 [active] 762376019501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019502 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376019503 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376019504 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376019505 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 762376019506 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 762376019507 active site 762376019508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019510 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 762376019511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762376019512 Walker A motif; other site 762376019513 ATP binding site [chemical binding]; other site 762376019514 Walker B motif; other site 762376019515 arginine finger; other site 762376019516 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 762376019517 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 762376019518 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 762376019519 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 762376019520 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 762376019521 active site 762376019522 DNA binding site [nucleotide binding] 762376019523 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 762376019524 DNA binding site [nucleotide binding] 762376019525 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862 762376019526 nucleotide binding site [chemical binding]; other site 762376019527 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762376019528 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 762376019529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376019530 Phage integrase family; Region: Phage_integrase; pfam00589 762376019531 DNA binding site [nucleotide binding] 762376019532 Int/Topo IB signature motif; other site 762376019533 active site 762376019534 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376019535 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376019536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376019537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762376019538 ParA-like protein; Provisional; Region: PHA02518 762376019539 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 762376019540 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 762376019541 Int/Topo IB signature motif; other site 762376019542 DNA binding site [nucleotide binding] 762376019543 Verrucomicrobium spinosum paralogous family TIGR02599; Region: TIGR02599 762376019544 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 762376019545 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 762376019546 Putative exonuclease, RdgC; Region: RdgC; cl01122 762376019547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376019548 cofactor binding site; other site 762376019549 DNA binding site [nucleotide binding] 762376019550 substrate interaction site [chemical binding]; other site 762376019551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376019552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762376019553 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 762376019554 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 762376019555 active site 762376019556 substrate binding site [chemical binding]; other site 762376019557 Mg2+ binding site [ion binding]; other site 762376019558 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 762376019559 AAA-like domain; Region: AAA_10; pfam12846 762376019560 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 762376019561 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 762376019562 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 762376019563 active site 762376019564 catalytic residues [active] 762376019565 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 762376019566 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 762376019567 Autotransporter beta-domain; Region: Autotransporter; cl02365 762376019568 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762376019569 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762376019570 Active Sites [active] 762376019571 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 762376019572 PilS N terminal; Region: PilS; pfam08805 762376019573 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 762376019574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376019575 Walker A motif; other site 762376019576 ATP binding site [chemical binding]; other site 762376019577 Walker B motif; other site 762376019578 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 762376019579 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 762376019580 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 762376019581 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 762376019582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762376019583 Walker A motif; other site 762376019584 ATP binding site [chemical binding]; other site 762376019585 Walker B motif; other site 762376019586 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 762376019587 StbA protein; Region: StbA; pfam06406 762376019588 PRTRC system protein D; Region: PRTRC_D; TIGR03739 762376019589 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762376019590 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762376019591 putative recombination protein RecB; Provisional; Region: PRK13909 762376019592 translation initiation factor 2; Provisional; Region: infB; CHL00189 762376019593 Cupin domain; Region: Cupin_2; cl09118 762376019594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376019595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376019596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376019597 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376019598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376019599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019600 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376019601 HipA N-terminal domain; Region: couple_hipA; TIGR03071 762376019602 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376019603 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376019604 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376019605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376019606 non-specific DNA binding site [nucleotide binding]; other site 762376019607 salt bridge; other site 762376019608 sequence-specific DNA binding site [nucleotide binding]; other site 762376019609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376019610 non-specific DNA binding site [nucleotide binding]; other site 762376019611 salt bridge; other site 762376019612 sequence-specific DNA binding site [nucleotide binding]; other site 762376019613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762376019614 HipA N-terminal domain; Region: couple_hipA; TIGR03071 762376019615 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376019616 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376019617 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 762376019618 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 762376019619 active site 762376019620 metal binding site [ion binding]; metal-binding site 762376019621 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 762376019622 domain I; other site 762376019623 DNA binding groove [nucleotide binding] 762376019624 phosphate binding site [ion binding]; other site 762376019625 domain II; other site 762376019626 domain III; other site 762376019627 nucleotide binding site [chemical binding]; other site 762376019628 catalytic site [active] 762376019629 domain IV; other site 762376019630 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762376019631 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 762376019632 AAA-like domain; Region: AAA_10; pfam12846 762376019633 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 762376019634 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376019635 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 762376019636 DNA primase, catalytic core; Region: dnaG; TIGR01391 762376019637 CHC2 zinc finger; Region: zf-CHC2; cl02597 762376019638 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762376019639 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762376019640 active site 762376019641 metal binding site [ion binding]; metal-binding site 762376019642 interdomain interaction site; other site 762376019643 H-NS histone family; Region: Histone_HNS; pfam00816 762376019644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762376019645 ParA-like protein; Provisional; Region: PHA02518 762376019646 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762376019647 P-loop; other site 762376019648 Magnesium ion binding site [ion binding]; other site 762376019649 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 762376019650 ParB-like nuclease domain; Region: ParBc; cl02129