-- dump date 20120504_131612 -- class Genbank::misc_feature -- table misc_feature_note -- id note 696749000001 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 696749000002 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 696749000003 active site 696749000004 HIGH motif; other site 696749000005 dimer interface [polypeptide binding]; other site 696749000006 KMSKS motif; other site 696749000007 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 696749000008 short chain dehydrogenase; Validated; Region: PRK05855 696749000009 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 696749000010 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 696749000011 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749000012 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 696749000013 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749000014 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749000015 ABC transporter; Region: ABC_tran_2; pfam12848 696749000016 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749000017 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 696749000018 Cytochrome b562; Region: Cytochrom_B562; cl01546 696749000019 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 696749000020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749000021 Mg2+ binding site [ion binding]; other site 696749000022 G-X-G motif; other site 696749000023 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 696749000024 anchoring element; other site 696749000025 dimer interface [polypeptide binding]; other site 696749000026 ATP binding site [chemical binding]; other site 696749000027 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 696749000028 active site 696749000029 putative metal-binding site [ion binding]; other site 696749000030 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 696749000031 recombination protein F; Reviewed; Region: recF; PRK00064 696749000032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000033 Walker A/P-loop; other site 696749000034 ATP binding site [chemical binding]; other site 696749000035 Q-loop/lid; other site 696749000036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000037 ABC transporter signature motif; other site 696749000038 Walker B; other site 696749000039 D-loop; other site 696749000040 H-loop/switch region; other site 696749000041 DNA polymerase III subunit beta; Validated; Region: PRK05643 696749000042 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 696749000043 putative DNA binding surface [nucleotide binding]; other site 696749000044 dimer interface [polypeptide binding]; other site 696749000045 beta-clamp/clamp loader binding surface; other site 696749000046 beta-clamp/translesion DNA polymerase binding surface; other site 696749000047 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 696749000048 DnaA N-terminal domain; Region: DnaA_N; pfam11638 696749000049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749000050 Walker A motif; other site 696749000051 ATP binding site [chemical binding]; other site 696749000052 Walker B motif; other site 696749000053 arginine finger; other site 696749000054 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 696749000055 DnaA box-binding interface [nucleotide binding]; other site 696749000056 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 696749000057 Ribonuclease P; Region: Ribonuclease_P; cl00457 696749000058 Haemolytic domain; Region: Haemolytic; cl00506 696749000059 membrane protein insertase; Provisional; Region: PRK01318 696749000060 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 696749000061 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 696749000062 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 696749000063 trmE is a tRNA modification GTPase; Region: trmE; cd04164 696749000064 G1 box; other site 696749000065 GTP/Mg2+ binding site [chemical binding]; other site 696749000066 Switch I region; other site 696749000067 G2 box; other site 696749000068 Switch II region; other site 696749000069 G3 box; other site 696749000070 G4 box; other site 696749000071 G5 box; other site 696749000072 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 696749000073 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 696749000074 putative metal binding site [ion binding]; other site 696749000075 putative homodimer interface [polypeptide binding]; other site 696749000076 putative homotetramer interface [polypeptide binding]; other site 696749000077 putative homodimer-homodimer interface [polypeptide binding]; other site 696749000078 putative allosteric switch controlling residues; other site 696749000079 Cation efflux family; Region: Cation_efflux; cl00316 696749000080 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 696749000081 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 696749000082 dimerization domain [polypeptide binding]; other site 696749000083 dimer interface [polypeptide binding]; other site 696749000084 catalytic residues [active] 696749000085 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 696749000086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749000087 active site 696749000088 guanine deaminase; Provisional; Region: PRK09228 696749000089 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 696749000090 active site 696749000091 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 696749000092 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 696749000093 [2Fe-2S] cluster binding site [ion binding]; other site 696749000094 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 696749000095 hydrophobic ligand binding site; other site 696749000096 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 696749000097 Integral membrane protein TerC family; Region: TerC; cl10468 696749000098 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 696749000099 active site 696749000100 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 696749000101 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 696749000102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696749000103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749000104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749000105 Protein of unknown function, DUF486; Region: DUF486; cl01236 696749000106 AIR carboxylase; Region: AIRC; cl00310 696749000107 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 696749000108 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749000109 Transglycosylase SLT domain; Region: SLT_2; pfam13406 696749000110 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 696749000111 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 696749000112 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 696749000113 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 696749000114 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 696749000115 active site 696749000116 active site 696749000117 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 696749000118 active site 696749000119 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 696749000120 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 696749000121 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 696749000122 dimer interface [polypeptide binding]; other site 696749000123 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 696749000124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749000125 Helix-turn-helix domains; Region: HTH; cl00088 696749000126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749000127 putative effector binding pocket; other site 696749000128 dimerization interface [polypeptide binding]; other site 696749000129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749000130 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 696749000131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749000132 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 696749000133 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 696749000134 substrate binding site [chemical binding]; other site 696749000135 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 696749000136 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 696749000137 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749000138 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749000139 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 696749000140 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 696749000141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749000142 active site 696749000143 HIGH motif; other site 696749000144 nucleotide binding site [chemical binding]; other site 696749000145 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 696749000146 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 696749000147 active site 696749000148 KMSKS motif; other site 696749000149 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 696749000150 tRNA binding surface [nucleotide binding]; other site 696749000151 anticodon binding site; other site 696749000152 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 696749000153 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 696749000154 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 696749000155 active site 696749000156 Riboflavin kinase; Region: Flavokinase; cl03312 696749000157 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 696749000158 gating phenylalanine in ion channel; other site 696749000159 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 696749000160 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 696749000161 Helix-turn-helix domains; Region: HTH; cl00088 696749000162 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 696749000163 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 696749000164 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 696749000165 Walker A/P-loop; other site 696749000166 ATP binding site [chemical binding]; other site 696749000167 Q-loop/lid; other site 696749000168 ABC transporter signature motif; other site 696749000169 Walker B; other site 696749000170 D-loop; other site 696749000171 H-loop/switch region; other site 696749000172 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 696749000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749000174 putative PBP binding loops; other site 696749000175 dimer interface [polypeptide binding]; other site 696749000176 ABC-ATPase subunit interface; other site 696749000177 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 696749000178 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 696749000179 active site 696749000180 dimer interface [polypeptide binding]; other site 696749000181 non-prolyl cis peptide bond; other site 696749000182 insertion regions; other site 696749000183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 696749000184 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749000185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749000186 substrate binding pocket [chemical binding]; other site 696749000187 membrane-bound complex binding site; other site 696749000188 hinge residues; other site 696749000189 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749000190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749000191 substrate binding pocket [chemical binding]; other site 696749000192 membrane-bound complex binding site; other site 696749000193 N-acetylglutamate synthase; Validated; Region: PRK05279 696749000194 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 696749000195 putative feedback inhibition sensing region; other site 696749000196 putative nucleotide binding site [chemical binding]; other site 696749000197 putative substrate binding site [chemical binding]; other site 696749000198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749000199 Coenzyme A binding pocket [chemical binding]; other site 696749000200 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 696749000201 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 696749000202 short chain dehydrogenase; Provisional; Region: PRK08703 696749000203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000204 NAD(P) binding site [chemical binding]; other site 696749000205 active site 696749000206 phosphoglycolate phosphatase; Provisional; Region: PRK13222 696749000207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749000208 active site 696749000209 motif I; other site 696749000210 motif II; other site 696749000211 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 696749000212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749000213 S-adenosylmethionine binding site [chemical binding]; other site 696749000214 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 696749000215 catalytic residues [active] 696749000216 hinge region; other site 696749000217 alpha helical domain; other site 696749000218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749000219 Helix-turn-helix domains; Region: HTH; cl00088 696749000220 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 696749000221 Helix-turn-helix domains; Region: HTH; cl00088 696749000222 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 696749000223 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 696749000224 FAD binding pocket [chemical binding]; other site 696749000225 FAD binding motif [chemical binding]; other site 696749000226 phosphate binding motif [ion binding]; other site 696749000227 beta-alpha-beta structure motif; other site 696749000228 NAD binding pocket [chemical binding]; other site 696749000229 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749000230 catalytic loop [active] 696749000231 iron binding site [ion binding]; other site 696749000232 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 696749000233 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 696749000234 putative di-iron ligands [ion binding]; other site 696749000235 ribonuclease PH; Reviewed; Region: rph; PRK00173 696749000236 Ribonuclease PH; Region: RNase_PH_bact; cd11362 696749000237 hexamer interface [polypeptide binding]; other site 696749000238 active site 696749000239 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 696749000240 Phosphoesterase family; Region: Phosphoesterase; cl15450 696749000241 Domain of unknown function (DUF756); Region: DUF756; pfam05506 696749000242 Domain of unknown function (DUF756); Region: DUF756; pfam05506 696749000243 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 696749000244 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 696749000245 dimerization interface [polypeptide binding]; other site 696749000246 active site 696749000247 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 696749000248 amidase catalytic site [active] 696749000249 Zn binding residues [ion binding]; other site 696749000250 substrate binding site [chemical binding]; other site 696749000251 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 696749000252 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 696749000253 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 696749000254 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749000255 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 696749000256 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 696749000257 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749000258 tyrosine kinase; Provisional; Region: PRK11519 696749000259 Chain length determinant protein; Region: Wzz; cl15801 696749000260 Chain length determinant protein; Region: Wzz; cl15801 696749000261 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 696749000262 P loop; other site 696749000263 Nucleotide binding site [chemical binding]; other site 696749000264 DTAP/Switch II; other site 696749000265 Switch I; other site 696749000266 Low molecular weight phosphatase family; Region: LMWPc; cd00115 696749000267 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 696749000268 active site 696749000269 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 696749000270 polysaccharide export protein Wza; Provisional; Region: PRK15078 696749000271 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 696749000272 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 696749000273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000274 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 696749000275 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 696749000276 NAD(P) binding site [chemical binding]; other site 696749000277 homodimer interface [polypeptide binding]; other site 696749000278 substrate binding site [chemical binding]; other site 696749000279 active site 696749000280 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 696749000281 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 696749000282 inhibitor-cofactor binding pocket; inhibition site 696749000283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749000284 catalytic residue [active] 696749000285 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 696749000286 ligand binding site; other site 696749000287 tetramer interface; other site 696749000288 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 696749000289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696749000290 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 696749000291 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749000292 pseudaminic acid synthase; Region: PseI; TIGR03586 696749000293 NeuB family; Region: NeuB; cl00496 696749000294 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 696749000295 NeuB binding interface [polypeptide binding]; other site 696749000296 putative substrate binding site [chemical binding]; other site 696749000297 MatE; Region: MatE; cl10513 696749000298 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 696749000299 Core-2/I-Branching enzyme; Region: Branch; pfam02485 696749000300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 696749000301 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749000302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749000303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 696749000304 Bacterial sugar transferase; Region: Bac_transf; cl00939 696749000305 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 696749000306 active site 696749000307 tetramer interface; other site 696749000308 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 696749000309 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 696749000310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000311 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 696749000312 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 696749000313 active site 696749000314 dimer interface [polypeptide binding]; other site 696749000315 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 696749000316 dimer interface [polypeptide binding]; other site 696749000317 active site 696749000318 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 696749000319 UDP-glucose 4-epimerase; Region: PLN02240 696749000320 NAD binding site [chemical binding]; other site 696749000321 homodimer interface [polypeptide binding]; other site 696749000322 active site 696749000323 substrate binding site [chemical binding]; other site 696749000324 phosphomannomutase CpsG; Provisional; Region: PRK15414 696749000325 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 696749000326 active site 696749000327 substrate binding site [chemical binding]; other site 696749000328 metal binding site [ion binding]; metal-binding site 696749000329 L-lactate permease; Region: Lactate_perm; cl00701 696749000330 glycolate transporter; Provisional; Region: PRK09695 696749000331 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 696749000332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749000333 DNA-binding site [nucleotide binding]; DNA binding site 696749000334 FCD domain; Region: FCD; cl11656 696749000335 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 696749000336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 696749000337 phosphate binding site [ion binding]; other site 696749000338 D-lactate dehydrogenase; Provisional; Region: PRK11183 696749000339 FAD binding domain; Region: FAD_binding_4; pfam01565 696749000340 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 696749000341 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 696749000342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749000343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749000344 homodimer interface [polypeptide binding]; other site 696749000345 catalytic residue [active] 696749000346 Transcriptional regulators [Transcription]; Region: GntR; COG1802 696749000347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749000348 DNA-binding site [nucleotide binding]; DNA binding site 696749000349 FCD domain; Region: FCD; cl11656 696749000350 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 696749000351 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 696749000352 tetramer interface [polypeptide binding]; other site 696749000353 active site 696749000354 Mg2+/Mn2+ binding site [ion binding]; other site 696749000355 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 696749000356 Citrate synthase; Region: Citrate_synt; pfam00285 696749000357 oxalacetate binding site [chemical binding]; other site 696749000358 citrylCoA binding site [chemical binding]; other site 696749000359 coenzyme A binding site [chemical binding]; other site 696749000360 catalytic triad [active] 696749000361 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 696749000362 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 696749000363 substrate binding site [chemical binding]; other site 696749000364 ligand binding site [chemical binding]; other site 696749000365 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 696749000366 substrate binding site [chemical binding]; other site 696749000367 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 696749000368 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 696749000369 nudix motif; other site 696749000370 PemK-like protein; Region: PemK; cl00995 696749000371 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 696749000372 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 696749000373 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696749000374 dimer interface [polypeptide binding]; other site 696749000375 active site 696749000376 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 696749000377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000378 NAD(P) binding site [chemical binding]; other site 696749000379 active site 696749000380 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 696749000381 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696749000382 active site 696749000383 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 696749000384 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749000385 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749000386 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749000387 N-terminal plug; other site 696749000388 ligand-binding site [chemical binding]; other site 696749000389 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 696749000390 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 696749000391 Helix-turn-helix domains; Region: HTH; cl00088 696749000392 AsnC family; Region: AsnC_trans_reg; pfam01037 696749000393 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 696749000394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749000395 mRNA stabilisation; Region: mRNA_stabil; pfam13929 696749000396 alanine racemase; Reviewed; Region: dadX; PRK03646 696749000397 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 696749000398 active site 696749000399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696749000400 substrate binding site [chemical binding]; other site 696749000401 catalytic residues [active] 696749000402 dimer interface [polypeptide binding]; other site 696749000403 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 696749000404 homotrimer interaction site [polypeptide binding]; other site 696749000405 putative active site [active] 696749000406 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 696749000407 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 696749000408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749000409 Helix-turn-helix domains; Region: HTH; cl00088 696749000410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749000411 dimerization interface [polypeptide binding]; other site 696749000412 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 696749000413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749000414 tetrameric interface [polypeptide binding]; other site 696749000415 NAD binding site [chemical binding]; other site 696749000416 catalytic residues [active] 696749000417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000418 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 696749000419 acetyl-CoA synthetase; Provisional; Region: PRK04319 696749000420 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 696749000421 AMP-binding enzyme; Region: AMP-binding; cl15778 696749000422 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749000423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749000424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749000425 active site 696749000426 enoyl-CoA hydratase; Provisional; Region: PRK05862 696749000427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749000428 substrate binding site [chemical binding]; other site 696749000429 oxyanion hole (OAH) forming residues; other site 696749000430 trimer interface [polypeptide binding]; other site 696749000431 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 696749000432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749000433 substrate binding site [chemical binding]; other site 696749000434 oxyanion hole (OAH) forming residues; other site 696749000435 trimer interface [polypeptide binding]; other site 696749000436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 696749000437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000438 metabolite-proton symporter; Region: 2A0106; TIGR00883 696749000439 putative substrate translocation pore; other site 696749000440 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749000441 Autoinducer binding domain; Region: Autoind_bind; pfam03472 696749000442 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749000443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749000444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696749000445 dimerization interface [polypeptide binding]; other site 696749000446 DNA binding residues [nucleotide binding] 696749000447 acyl-CoA synthetase; Validated; Region: PRK05850 696749000448 AMP-binding enzyme; Region: AMP-binding; cl15778 696749000449 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749000450 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 696749000451 active site 696749000452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749000453 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 696749000454 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 696749000455 AMP-binding enzyme; Region: AMP-binding; cl15778 696749000456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749000457 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 696749000458 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 696749000459 hydrophobic ligand binding site; other site 696749000460 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 696749000461 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 696749000462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000463 NAD(P) binding site [chemical binding]; other site 696749000464 active site 696749000465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749000466 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749000467 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 696749000468 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 696749000469 BolA-like protein; Region: BolA; cl00386 696749000470 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 696749000471 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 696749000472 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749000473 P-loop; other site 696749000474 Magnesium ion binding site [ion binding]; other site 696749000475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749000476 Magnesium ion binding site [ion binding]; other site 696749000477 LysE type translocator; Region: LysE; cl00565 696749000478 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 696749000479 DoxX; Region: DoxX; cl00976 696749000480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 696749000481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 696749000482 GMP synthase; Reviewed; Region: guaA; PRK00074 696749000483 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 696749000484 AMP/PPi binding site [chemical binding]; other site 696749000485 candidate oxyanion hole; other site 696749000486 catalytic triad [active] 696749000487 potential glutamine specificity residues [chemical binding]; other site 696749000488 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 696749000489 ATP Binding subdomain [chemical binding]; other site 696749000490 Ligand Binding sites [chemical binding]; other site 696749000491 Dimerization subdomain; other site 696749000492 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 696749000493 active site 696749000494 NTP binding site [chemical binding]; other site 696749000495 metal binding triad [ion binding]; metal-binding site 696749000496 antibiotic binding site [chemical binding]; other site 696749000497 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 696749000498 Helix-turn-helix domains; Region: HTH; cl00088 696749000499 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 696749000500 Pirin-related protein [General function prediction only]; Region: COG1741 696749000501 Cupin domain; Region: Cupin_2; cl09118 696749000502 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 696749000503 OsmC-like protein; Region: OsmC; cl00767 696749000504 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 696749000505 putative dimer interface [polypeptide binding]; other site 696749000506 putative GSH binding site (G-site) [chemical binding]; other site 696749000507 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 696749000508 putative N-terminal domain interface [polypeptide binding]; other site 696749000509 putative dimer interface [polypeptide binding]; other site 696749000510 putative substrate binding pocket (H-site) [chemical binding]; other site 696749000511 cell division protein FtsN; Region: ftsN; TIGR02223 696749000512 Sporulation related domain; Region: SPOR; cl10051 696749000513 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 696749000514 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 696749000515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749000516 active site 696749000517 HIGH motif; other site 696749000518 nucleotide binding site [chemical binding]; other site 696749000519 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 696749000520 KMSK motif region; other site 696749000521 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 696749000522 tRNA binding surface [nucleotide binding]; other site 696749000523 anticodon binding site; other site 696749000524 malate dehydrogenase; Provisional; Region: PRK13529 696749000525 Malic enzyme, N-terminal domain; Region: malic; pfam00390 696749000526 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 696749000527 NAD(P) binding site [chemical binding]; other site 696749000528 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 696749000529 LysE type translocator; Region: LysE; cl00565 696749000530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696749000531 ABC-ATPase subunit interface; other site 696749000532 dimer interface [polypeptide binding]; other site 696749000533 putative PBP binding regions; other site 696749000534 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 696749000535 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000536 Walker A/P-loop; other site 696749000537 ATP binding site [chemical binding]; other site 696749000538 Q-loop/lid; other site 696749000539 ABC transporter signature motif; other site 696749000540 Walker B; other site 696749000541 D-loop; other site 696749000542 H-loop/switch region; other site 696749000543 Helix-turn-helix domains; Region: HTH; cl00088 696749000544 metal binding site 2 [ion binding]; metal-binding site 696749000545 putative DNA binding helix; other site 696749000546 metal binding site 1 [ion binding]; metal-binding site 696749000547 dimer interface [polypeptide binding]; other site 696749000548 structural Zn2+ binding site [ion binding]; other site 696749000549 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 696749000550 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 696749000551 intersubunit interface [polypeptide binding]; other site 696749000552 ATP synthase I chain; Region: ATP_synt_I; cl09170 696749000553 ATP synthase A chain; Region: ATP-synt_A; cl00413 696749000554 ATP synthase subunit C; Region: ATP-synt_C; cl00466 696749000555 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 696749000556 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 696749000557 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 696749000558 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 696749000559 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 696749000560 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 696749000561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000562 Walker A motif; other site 696749000563 ATP binding site [chemical binding]; other site 696749000564 Walker B motif; other site 696749000565 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 696749000566 ATP synthase; Region: ATP-synt; cl00365 696749000567 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 696749000568 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 696749000569 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 696749000570 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 696749000571 alpha subunit interaction interface [polypeptide binding]; other site 696749000572 Walker A motif; other site 696749000573 ATP binding site [chemical binding]; other site 696749000574 Walker B motif; other site 696749000575 inhibitor binding site; inhibition site 696749000576 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 696749000577 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 696749000578 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 696749000579 catalytic residues [active] 696749000580 dimer interface [polypeptide binding]; other site 696749000581 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749000582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749000583 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 696749000584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000585 putative substrate translocation pore; other site 696749000586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749000587 Helix-turn-helix domains; Region: HTH; cl00088 696749000588 EamA-like transporter family; Region: EamA; cl01037 696749000589 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749000590 EamA-like transporter family; Region: EamA; cl01037 696749000591 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 696749000592 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 696749000593 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 696749000594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749000595 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 696749000596 active site 696749000597 catalytic residues [active] 696749000598 metal binding site [ion binding]; metal-binding site 696749000599 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 696749000600 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749000601 N-terminal plug; other site 696749000602 ligand-binding site [chemical binding]; other site 696749000603 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 696749000604 Helix-turn-helix domains; Region: HTH; cl00088 696749000605 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749000606 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 696749000607 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 696749000608 dimer interface [polypeptide binding]; other site 696749000609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749000610 catalytic residue [active] 696749000611 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 696749000612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749000613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749000614 catalytic residue [active] 696749000615 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749000616 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 696749000617 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 696749000618 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 696749000619 DNA binding residues [nucleotide binding] 696749000620 putative dimer interface [polypeptide binding]; other site 696749000621 putative metal binding residues [ion binding]; other site 696749000622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 696749000623 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 696749000624 active site 696749000625 hypothetical protein; Provisional; Region: PRK01254 696749000626 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 696749000627 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 696749000628 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 696749000629 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 696749000630 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 696749000631 homotrimer interaction site [polypeptide binding]; other site 696749000632 putative active site [active] 696749000633 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 696749000634 active site 696749000635 DNA polymerase IV; Validated; Region: PRK02406 696749000636 DNA binding site [nucleotide binding] 696749000637 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 696749000638 active site 696749000639 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 696749000640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000641 putative transporter; Provisional; Region: PRK10504 696749000642 putative substrate translocation pore; other site 696749000643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000644 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 696749000645 Integral membrane protein TerC family; Region: TerC; cl10468 696749000646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696749000647 Transporter associated domain; Region: CorC_HlyC; cl08393 696749000648 hypothetical protein; Provisional; Region: PRK01752 696749000649 SEC-C motif; Region: SEC-C; pfam02810 696749000650 Predicted membrane protein [Function unknown]; Region: COG2860 696749000651 UPF0126 domain; Region: UPF0126; pfam03458 696749000652 UPF0126 domain; Region: UPF0126; pfam03458 696749000653 benzoate transport; Region: 2A0115; TIGR00895 696749000654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000655 putative substrate translocation pore; other site 696749000656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749000657 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 696749000658 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 696749000659 CAP-like domain; other site 696749000660 active site 696749000661 primary dimer interface [polypeptide binding]; other site 696749000662 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 696749000663 AMP-binding enzyme; Region: AMP-binding; cl15778 696749000664 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749000665 MAPEG family; Region: MAPEG; cl09190 696749000666 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 696749000667 dimer interface [polypeptide binding]; other site 696749000668 substrate binding site [chemical binding]; other site 696749000669 metal binding sites [ion binding]; metal-binding site 696749000670 outer membrane porin, OprD family; Region: OprD; pfam03573 696749000671 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 696749000672 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 696749000673 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 696749000674 inhibitor site; inhibition site 696749000675 active site 696749000676 dimer interface [polypeptide binding]; other site 696749000677 catalytic residue [active] 696749000678 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 696749000679 intersubunit interface [polypeptide binding]; other site 696749000680 active site 696749000681 Zn2+ binding site [ion binding]; other site 696749000682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749000683 DNA-binding site [nucleotide binding]; DNA binding site 696749000684 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749000685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749000686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749000687 homodimer interface [polypeptide binding]; other site 696749000688 catalytic residue [active] 696749000689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000690 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 696749000691 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 696749000692 Helix-turn-helix domains; Region: HTH; cl00088 696749000693 Integrase core domain; Region: rve; cl01316 696749000694 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 696749000695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000696 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749000697 Ligand Binding Site [chemical binding]; other site 696749000698 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749000699 Ligand Binding Site [chemical binding]; other site 696749000700 Sulfate transporter family; Region: Sulfate_transp; cl15842 696749000701 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 696749000702 Sulfate transporter family; Region: Sulfate_transp; cl15842 696749000703 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 696749000704 AAA domain; Region: AAA_33; pfam13671 696749000705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000706 Fic family protein [Function unknown]; Region: COG3177 696749000707 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 696749000708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749000709 active site 696749000710 DNA binding site [nucleotide binding] 696749000711 Int/Topo IB signature motif; other site 696749000712 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 696749000713 Helix-turn-helix domains; Region: HTH; cl00088 696749000714 Integrase core domain; Region: rve; cl01316 696749000715 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749000716 dihydropteroate synthase; Region: DHPS; TIGR01496 696749000717 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 696749000718 substrate binding pocket [chemical binding]; other site 696749000719 dimer interface [polypeptide binding]; other site 696749000720 inhibitor binding site; inhibition site 696749000721 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 696749000722 Putative transposase; Region: Y2_Tnp; pfam04986 696749000723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749000724 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 696749000725 Phosphotransferase enzyme family; Region: APH; pfam01636 696749000726 active site 696749000727 ATP binding site [chemical binding]; other site 696749000728 antibiotic binding site [chemical binding]; other site 696749000729 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 696749000730 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749000731 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 696749000732 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 696749000733 C-terminal domain interface [polypeptide binding]; other site 696749000734 GSH binding site (G-site) [chemical binding]; other site 696749000735 dimer interface [polypeptide binding]; other site 696749000736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749000737 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749000738 HTH-like domain; Region: HTH_21; pfam13276 696749000739 DDE domain; Region: DDE_Tnp_IS240; pfam13610 696749000740 Integrase core domain; Region: rve; cl01316 696749000741 Integrase core domain; Region: rve_3; cl15866 696749000742 Helix-turn-helix domains; Region: HTH; cl00088 696749000743 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 696749000744 Phosphotransferase enzyme family; Region: APH; pfam01636 696749000745 active site 696749000746 ATP binding site [chemical binding]; other site 696749000747 antibiotic binding site [chemical binding]; other site 696749000748 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 696749000749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749000750 Membrane fusogenic activity; Region: BMFP; cl01115 696749000751 Nitrogen regulatory protein P-II; Region: P-II; cl00412 696749000752 Nitrogen regulatory protein P-II; Region: P-II; smart00938 696749000753 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 696749000754 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 696749000755 ATP cone domain; Region: ATP-cone; pfam03477 696749000756 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 696749000757 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 696749000758 catalytic motif [active] 696749000759 Zn binding site [ion binding]; other site 696749000760 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 696749000761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749000762 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 696749000763 Lumazine binding domain; Region: Lum_binding; pfam00677 696749000764 Lumazine binding domain; Region: Lum_binding; pfam00677 696749000765 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 696749000766 multifunctional aminopeptidase A; Provisional; Region: PRK00913 696749000767 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 696749000768 interface (dimer of trimers) [polypeptide binding]; other site 696749000769 Substrate-binding/catalytic site; other site 696749000770 Zn-binding sites [ion binding]; other site 696749000771 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 696749000772 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 696749000773 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 696749000774 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 696749000775 Sulfatase; Region: Sulfatase; cl10460 696749000776 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 696749000777 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 696749000778 C-terminal peptidase (prc); Region: prc; TIGR00225 696749000779 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 696749000780 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 696749000781 Catalytic dyad [active] 696749000782 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 696749000783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749000784 active site 696749000785 phosphorylation site [posttranslational modification] 696749000786 intermolecular recognition site; other site 696749000787 dimerization interface [polypeptide binding]; other site 696749000788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749000789 Walker A motif; other site 696749000790 ATP binding site [chemical binding]; other site 696749000791 Walker B motif; other site 696749000792 arginine finger; other site 696749000793 Helix-turn-helix domains; Region: HTH; cl00088 696749000794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 696749000795 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 696749000796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749000797 dimer interface [polypeptide binding]; other site 696749000798 phosphorylation site [posttranslational modification] 696749000799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749000800 ATP binding site [chemical binding]; other site 696749000801 Mg2+ binding site [ion binding]; other site 696749000802 G-X-G motif; other site 696749000803 response regulator; Provisional; Region: PRK09483 696749000804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749000805 active site 696749000806 phosphorylation site [posttranslational modification] 696749000807 intermolecular recognition site; other site 696749000808 dimerization interface [polypeptide binding]; other site 696749000809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696749000810 DNA binding residues [nucleotide binding] 696749000811 dimerization interface [polypeptide binding]; other site 696749000812 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 696749000813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749000814 threonine synthase; Reviewed; Region: PRK06721 696749000815 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 696749000816 homodimer interface [polypeptide binding]; other site 696749000817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749000818 catalytic residue [active] 696749000819 homoserine dehydrogenase; Provisional; Region: PRK06349 696749000820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749000821 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 696749000822 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 696749000823 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 696749000824 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 696749000825 dimerization domain [polypeptide binding]; other site 696749000826 dimer interface [polypeptide binding]; other site 696749000827 catalytic residues [active] 696749000828 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 696749000829 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 696749000830 active site 696749000831 Int/Topo IB signature motif; other site 696749000832 FeoA domain; Region: FeoA; cl00838 696749000833 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 696749000834 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 696749000835 G1 box; other site 696749000836 GTP/Mg2+ binding site [chemical binding]; other site 696749000837 Switch I region; other site 696749000838 G2 box; other site 696749000839 G3 box; other site 696749000840 Switch II region; other site 696749000841 G4 box; other site 696749000842 G5 box; other site 696749000843 Nucleoside recognition; Region: Gate; cl00486 696749000844 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 696749000845 Nucleoside recognition; Region: Gate; cl00486 696749000846 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 696749000847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749000848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749000849 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 696749000850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749000851 active site 696749000852 nucleotide binding site [chemical binding]; other site 696749000853 HIGH motif; other site 696749000854 KMSKS motif; other site 696749000855 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 696749000856 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 696749000857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696749000858 active site 696749000859 metal binding site [ion binding]; metal-binding site 696749000860 hexamer interface [polypeptide binding]; other site 696749000861 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 696749000862 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 696749000863 dimer interface [polypeptide binding]; other site 696749000864 ADP-ribose binding site [chemical binding]; other site 696749000865 active site 696749000866 nudix motif; other site 696749000867 metal binding site [ion binding]; metal-binding site 696749000868 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 696749000869 ThiC-associated domain; Region: ThiC-associated; pfam13667 696749000870 ThiC family; Region: ThiC; cl08031 696749000871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749000872 Helix-turn-helix domains; Region: HTH; cl00088 696749000873 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749000874 EamA-like transporter family; Region: EamA; cl01037 696749000875 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 696749000876 transcriptional regulator PhoU; Provisional; Region: PRK11115 696749000877 PhoU domain; Region: PhoU; pfam01895 696749000878 PhoU domain; Region: PhoU; pfam01895 696749000879 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 696749000880 argininosuccinate lyase; Provisional; Region: PRK00855 696749000881 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 696749000882 active sites [active] 696749000883 tetramer interface [polypeptide binding]; other site 696749000884 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 696749000885 Histidine kinase; Region: His_kinase; pfam06580 696749000886 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 696749000887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749000888 active site 696749000889 phosphorylation site [posttranslational modification] 696749000890 intermolecular recognition site; other site 696749000891 dimerization interface [polypeptide binding]; other site 696749000892 LytTr DNA-binding domain; Region: LytTR; cl04498 696749000893 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 696749000894 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 696749000895 domain interfaces; other site 696749000896 active site 696749000897 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 696749000898 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 696749000899 active site 696749000900 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696749000901 active site 696749000902 H-NS histone family; Region: Histone_HNS; pfam00816 696749000903 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 696749000904 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 696749000905 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 696749000906 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 696749000907 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696749000908 type II secretion system protein D; Region: type_II_gspD; TIGR02517 696749000909 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 696749000910 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 696749000911 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 696749000912 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 696749000913 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 696749000914 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 696749000915 phosphopeptide binding site; other site 696749000916 phosphoglycolate phosphatase; Provisional; Region: PRK13222 696749000917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749000918 motif II; other site 696749000919 anthranilate synthase component I; Provisional; Region: PRK13565 696749000920 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 696749000921 chorismate binding enzyme; Region: Chorismate_bind; cl10555 696749000922 elongation factor Tu; Reviewed; Region: PRK00049 696749000923 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 696749000924 G1 box; other site 696749000925 GEF interaction site [polypeptide binding]; other site 696749000926 GTP/Mg2+ binding site [chemical binding]; other site 696749000927 Switch I region; other site 696749000928 G2 box; other site 696749000929 G3 box; other site 696749000930 Switch II region; other site 696749000931 G4 box; other site 696749000932 G5 box; other site 696749000933 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 696749000934 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 696749000935 Antibiotic Binding Site [chemical binding]; other site 696749000936 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 696749000937 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 696749000938 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 696749000939 putative homodimer interface [polypeptide binding]; other site 696749000940 KOW motif; Region: KOW; cl00354 696749000941 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 696749000942 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 696749000943 23S rRNA interface [nucleotide binding]; other site 696749000944 L7/L12 interface [polypeptide binding]; other site 696749000945 putative thiostrepton binding site; other site 696749000946 L25 interface [polypeptide binding]; other site 696749000947 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 696749000948 mRNA/rRNA interface [nucleotide binding]; other site 696749000949 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 696749000950 23S rRNA interface [nucleotide binding]; other site 696749000951 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 696749000952 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 696749000953 core dimer interface [polypeptide binding]; other site 696749000954 peripheral dimer interface [polypeptide binding]; other site 696749000955 L10 interface [polypeptide binding]; other site 696749000956 L11 interface [polypeptide binding]; other site 696749000957 putative EF-Tu interaction site [polypeptide binding]; other site 696749000958 putative EF-G interaction site [polypeptide binding]; other site 696749000959 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 696749000960 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 696749000961 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 696749000962 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 696749000963 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 696749000964 RPB11 interaction site [polypeptide binding]; other site 696749000965 RPB12 interaction site [polypeptide binding]; other site 696749000966 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 696749000967 RPB1 interaction site [polypeptide binding]; other site 696749000968 RPB11 interaction site [polypeptide binding]; other site 696749000969 RPB10 interaction site [polypeptide binding]; other site 696749000970 RPB3 interaction site [polypeptide binding]; other site 696749000971 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 696749000972 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 696749000973 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 696749000974 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 696749000975 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 696749000976 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 696749000977 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 696749000978 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 696749000979 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 696749000980 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 696749000981 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 696749000982 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 696749000983 DNA binding site [nucleotide binding] 696749000984 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 696749000985 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749000986 CoenzymeA binding site [chemical binding]; other site 696749000987 subunit interaction site [polypeptide binding]; other site 696749000988 PHB binding site; other site 696749000989 short chain dehydrogenase; Validated; Region: PRK05855 696749000990 Predicted permease [General function prediction only]; Region: COG2056 696749000991 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 696749000992 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749000993 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 696749000994 heat shock protein 90; Provisional; Region: PRK05218 696749000995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749000996 ATP binding site [chemical binding]; other site 696749000997 Mg2+ binding site [ion binding]; other site 696749000998 G-X-G motif; other site 696749000999 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 696749001000 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 696749001001 catalytic residues [active] 696749001002 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696749001003 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 696749001004 DNA binding residues [nucleotide binding] 696749001005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749001006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 696749001007 hypothetical protein; Provisional; Region: PRK10215 696749001008 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 696749001009 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749001010 dimer interface [polypeptide binding]; other site 696749001011 active site 696749001012 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 696749001013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749001014 substrate binding site [chemical binding]; other site 696749001015 oxyanion hole (OAH) forming residues; other site 696749001016 trimer interface [polypeptide binding]; other site 696749001017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001018 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749001019 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749001020 Cupin domain; Region: Cupin_2; cl09118 696749001021 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 696749001022 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 696749001023 GIY-YIG motif/motif A; other site 696749001024 active site 696749001025 catalytic site [active] 696749001026 putative DNA binding site [nucleotide binding]; other site 696749001027 metal binding site [ion binding]; metal-binding site 696749001028 UvrB/uvrC motif; Region: UVR; pfam02151 696749001029 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 696749001030 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 696749001031 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 696749001032 active site 696749001033 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 696749001034 active site 696749001035 dimer interface [polypeptide binding]; other site 696749001036 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 696749001037 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 696749001038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749001039 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 696749001040 DNA binding site [nucleotide binding] 696749001041 active site 696749001042 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 696749001043 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749001044 Helix-turn-helix domains; Region: HTH; cl00088 696749001045 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749001046 Fusaric acid resistance protein family; Region: FUSC; pfam04632 696749001047 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 696749001048 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 696749001049 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 696749001050 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749001051 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749001052 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 696749001053 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 696749001054 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 696749001055 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 696749001056 Walker A/P-loop; other site 696749001057 ATP binding site [chemical binding]; other site 696749001058 Q-loop/lid; other site 696749001059 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 696749001060 ABC transporter signature motif; other site 696749001061 Walker B; other site 696749001062 D-loop; other site 696749001063 H-loop/switch region; other site 696749001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696749001065 binding surface 696749001066 Tetratricopeptide repeat; Region: TPR_16; pfam13432 696749001067 TPR motif; other site 696749001068 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 696749001069 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 696749001070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 696749001071 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 696749001072 EamA-like transporter family; Region: EamA; cl01037 696749001073 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 696749001074 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 696749001075 CoA-binding site [chemical binding]; other site 696749001076 ATP-binding [chemical binding]; other site 696749001077 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 696749001078 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 696749001079 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 696749001080 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 696749001081 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 696749001082 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 696749001083 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 696749001084 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 696749001085 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 696749001086 Walker A motif; other site 696749001087 ATP binding site [chemical binding]; other site 696749001088 Walker B motif; other site 696749001089 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 696749001090 substrate binding site [chemical binding]; other site 696749001091 dimer interface [polypeptide binding]; other site 696749001092 catalytic triad [active] 696749001093 Preprotein translocase SecG subunit; Region: SecG; cl09123 696749001094 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 696749001095 ribosome maturation protein RimP; Reviewed; Region: PRK00092 696749001096 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 696749001097 Sm1 motif; other site 696749001098 D1 - D2 interaction site; other site 696749001099 D3 - B interaction site; other site 696749001100 Hfq - Hfq interaction site; other site 696749001101 RNA binding pocket [nucleotide binding]; other site 696749001102 Sm2 motif; other site 696749001103 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 696749001104 NusA N-terminal domain; Region: NusA_N; pfam08529 696749001105 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 696749001106 RNA binding site [nucleotide binding]; other site 696749001107 homodimer interface [polypeptide binding]; other site 696749001108 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 696749001109 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 696749001110 G-X-X-G motif; other site 696749001111 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 696749001112 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 696749001113 translation initiation factor IF-2; Validated; Region: infB; PRK05306 696749001114 translation initiation factor IF-2; Region: IF-2; TIGR00487 696749001115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 696749001116 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 696749001117 G1 box; other site 696749001118 putative GEF interaction site [polypeptide binding]; other site 696749001119 GTP/Mg2+ binding site [chemical binding]; other site 696749001120 Switch I region; other site 696749001121 G2 box; other site 696749001122 G3 box; other site 696749001123 Switch II region; other site 696749001124 G4 box; other site 696749001125 G5 box; other site 696749001126 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 696749001127 Translation-initiation factor 2; Region: IF-2; pfam11987 696749001128 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 696749001129 Ribosome-binding factor A; Region: RBFA; cl00542 696749001130 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 696749001131 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 696749001132 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 696749001133 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 696749001134 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 696749001135 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 696749001136 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 696749001137 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 696749001138 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 696749001139 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 696749001140 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 696749001141 AAA domain; Region: AAA_23; pfam13476 696749001142 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 696749001143 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 696749001144 Family description; Region: UvrD_C_2; cl15862 696749001145 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 696749001146 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 696749001147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 696749001148 metal binding site [ion binding]; metal-binding site 696749001149 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 696749001150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001151 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 696749001152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749001153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 696749001154 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 696749001155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749001156 S-adenosylmethionine binding site [chemical binding]; other site 696749001157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749001158 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 696749001159 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 696749001160 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 696749001161 Domain of unknown function (DUF697); Region: DUF697; cl12064 696749001162 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 696749001163 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 696749001164 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 696749001165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749001166 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 696749001167 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 696749001168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749001169 AAA domain; Region: AAA_22; pfam13401 696749001170 Family description; Region: UvrD_C_2; cl15862 696749001171 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 696749001172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749001173 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 696749001174 16S/18S rRNA binding site [nucleotide binding]; other site 696749001175 S13e-L30e interaction site [polypeptide binding]; other site 696749001176 25S rRNA binding site [nucleotide binding]; other site 696749001177 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 696749001178 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 696749001179 RNase E interface [polypeptide binding]; other site 696749001180 trimer interface [polypeptide binding]; other site 696749001181 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 696749001182 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 696749001183 RNase E interface [polypeptide binding]; other site 696749001184 trimer interface [polypeptide binding]; other site 696749001185 active site 696749001186 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 696749001187 putative nucleic acid binding region [nucleotide binding]; other site 696749001188 G-X-X-G motif; other site 696749001189 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 696749001190 RNA binding site [nucleotide binding]; other site 696749001191 domain interface; other site 696749001192 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 696749001193 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 696749001194 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 696749001195 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 696749001196 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 696749001197 HSP70 interaction site [polypeptide binding]; other site 696749001198 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 696749001199 substrate binding site [polypeptide binding]; other site 696749001200 dimer interface [polypeptide binding]; other site 696749001201 LysE type translocator; Region: LysE; cl00565 696749001202 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 696749001203 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 696749001204 dimerization interface [polypeptide binding]; other site 696749001205 domain crossover interface; other site 696749001206 redox-dependent activation switch; other site 696749001207 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 696749001208 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 696749001209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001210 primosome assembly protein PriA; Validated; Region: PRK05580 696749001211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749001212 ATP binding site [chemical binding]; other site 696749001213 putative Mg++ binding site [ion binding]; other site 696749001214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749001215 type II secretion system protein F; Region: GspF; TIGR02120 696749001216 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 696749001217 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 696749001218 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 696749001219 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 696749001220 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749001221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749001222 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 696749001223 dimer interface [polypeptide binding]; other site 696749001224 putative tRNA-binding site [nucleotide binding]; other site 696749001225 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 696749001226 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 696749001227 putative active site [active] 696749001228 catalytic triad [active] 696749001229 putative dimer interface [polypeptide binding]; other site 696749001230 FOG: CBS domain [General function prediction only]; Region: COG0517 696749001231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696749001232 Transporter associated domain; Region: CorC_HlyC; cl08393 696749001233 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 696749001234 CPxP motif; other site 696749001235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001236 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 696749001237 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 696749001238 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 696749001239 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 696749001240 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 696749001241 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 696749001242 ferrochelatase; Reviewed; Region: hemH; PRK00035 696749001243 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 696749001244 C-terminal domain interface [polypeptide binding]; other site 696749001245 active site 696749001246 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 696749001247 active site 696749001248 N-terminal domain interface [polypeptide binding]; other site 696749001249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749001250 Domain of unknown function (DUF329); Region: DUF329; cl01144 696749001251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749001252 Predicted flavoproteins [General function prediction only]; Region: COG2081 696749001253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001255 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 696749001256 CrcB-like protein; Region: CRCB; cl09114 696749001257 HopJ type III effector protein; Region: HopJ; pfam08888 696749001258 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 696749001259 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749001260 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 696749001261 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 696749001262 Flavin binding site [chemical binding]; other site 696749001263 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 696749001264 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 696749001265 Flavin binding site [chemical binding]; other site 696749001266 multidrug efflux protein; Reviewed; Region: PRK01766 696749001267 MatE; Region: MatE; cl10513 696749001268 MatE; Region: MatE; cl10513 696749001269 Protein of unknown function, DUF606; Region: DUF606; cl01273 696749001270 HemN family oxidoreductase; Provisional; Region: PRK05660 696749001271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749001272 FeS/SAM binding site; other site 696749001273 HemN C-terminal domain; Region: HemN_C; pfam06969 696749001274 short chain dehydrogenase; Provisional; Region: PRK12744 696749001275 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 696749001276 NADP binding site [chemical binding]; other site 696749001277 homodimer interface [polypeptide binding]; other site 696749001278 active site 696749001279 substrate binding site [chemical binding]; other site 696749001280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749001281 Helix-turn-helix domains; Region: HTH; cl00088 696749001282 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 696749001283 putative effector binding pocket; other site 696749001284 putative dimerization interface [polypeptide binding]; other site 696749001285 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 696749001286 AMP-binding enzyme; Region: AMP-binding; cl15778 696749001287 ribonuclease E; Reviewed; Region: rne; PRK10811 696749001288 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 696749001289 homodimer interface [polypeptide binding]; other site 696749001290 oligonucleotide binding site [chemical binding]; other site 696749001291 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 696749001292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696749001293 RNA binding surface [nucleotide binding]; other site 696749001294 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696749001295 active site 696749001296 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 696749001297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749001298 motif II; other site 696749001299 Helix-turn-helix domains; Region: HTH; cl00088 696749001300 WYL domain; Region: WYL; cl14852 696749001301 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749001302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749001303 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 696749001304 putative dimer interface [polypeptide binding]; other site 696749001305 putative GSH binding site (G-site) [chemical binding]; other site 696749001306 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 696749001307 dimer interface [polypeptide binding]; other site 696749001308 N-terminal domain interface [polypeptide binding]; other site 696749001309 putative substrate binding pocket (H-site) [chemical binding]; other site 696749001310 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 696749001311 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749001312 Helix-turn-helix domains; Region: HTH; cl00088 696749001313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749001314 dimerization interface [polypeptide binding]; other site 696749001315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749001316 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 696749001317 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 696749001318 heme binding site [chemical binding]; other site 696749001319 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 696749001320 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 696749001321 GAF domain; Region: GAF; cl15785 696749001322 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 696749001323 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 696749001324 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 696749001325 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 696749001326 putative active site [active] 696749001327 Ap4A binding site [chemical binding]; other site 696749001328 nudix motif; other site 696749001329 putative metal binding site [ion binding]; other site 696749001330 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 696749001331 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749001332 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749001333 Helix-turn-helix domains; Region: HTH; cl00088 696749001334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749001335 dimerization interface [polypeptide binding]; other site 696749001336 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 696749001337 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 696749001338 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 696749001339 substrate binding site [chemical binding]; other site 696749001340 ligand binding site [chemical binding]; other site 696749001341 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 696749001342 substrate binding site [chemical binding]; other site 696749001343 tartrate dehydrogenase; Provisional; Region: PRK08194 696749001344 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 696749001345 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 696749001346 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 696749001347 rRNA binding site [nucleotide binding]; other site 696749001348 predicted 30S ribosome binding site; other site 696749001349 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749001350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749001351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749001352 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 696749001353 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 696749001354 dimerization interface 3.5A [polypeptide binding]; other site 696749001355 active site 696749001356 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 696749001357 active site 696749001358 homodimer interface [polypeptide binding]; other site 696749001359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 696749001360 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 696749001361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001362 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 696749001363 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 696749001364 putative catalytic site [active] 696749001365 putative metal binding site [ion binding]; other site 696749001366 putative phosphate binding site [ion binding]; other site 696749001367 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749001368 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749001369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 696749001370 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 696749001371 putative ADP-binding pocket [chemical binding]; other site 696749001372 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 696749001373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696749001374 putative acyl-acceptor binding pocket; other site 696749001375 LysE type translocator; Region: LysE; cl00565 696749001376 ABC transporter ATPase component; Reviewed; Region: PRK11147 696749001377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749001378 Walker A/P-loop; other site 696749001379 ATP binding site [chemical binding]; other site 696749001380 Q-loop/lid; other site 696749001381 ABC transporter signature motif; other site 696749001382 Walker B; other site 696749001383 D-loop; other site 696749001384 H-loop/switch region; other site 696749001385 ABC transporter; Region: ABC_tran_2; pfam12848 696749001386 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749001387 SlyX; Region: SlyX; cl01090 696749001388 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 696749001389 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 696749001390 putative NAD(P) binding site [chemical binding]; other site 696749001391 dimer interface [polypeptide binding]; other site 696749001392 Helix-turn-helix domains; Region: HTH; cl00088 696749001393 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 696749001394 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 696749001395 active site 696749001396 interdomain interaction site; other site 696749001397 putative metal-binding site [ion binding]; other site 696749001398 nucleotide binding site [chemical binding]; other site 696749001399 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 696749001400 domain I; other site 696749001401 DNA binding groove [nucleotide binding] 696749001402 phosphate binding site [ion binding]; other site 696749001403 domain II; other site 696749001404 domain III; other site 696749001405 nucleotide binding site [chemical binding]; other site 696749001406 catalytic site [active] 696749001407 domain IV; other site 696749001408 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696749001409 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696749001410 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 696749001411 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 696749001412 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 696749001413 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 696749001414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749001415 Family description; Region: UvrD_C_2; cl15862 696749001416 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 696749001417 RNA/DNA binding site [nucleotide binding]; other site 696749001418 RRM dimerization site [polypeptide binding]; other site 696749001419 putative cation:proton antiport protein; Provisional; Region: PRK10669 696749001420 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 696749001421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001422 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 696749001423 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 696749001424 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 696749001425 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 696749001426 NAD(P) binding site [chemical binding]; other site 696749001427 catalytic residues [active] 696749001428 Helix-turn-helix domains; Region: HTH; cl00088 696749001429 Bacterial transcriptional repressor; Region: TetR; pfam13972 696749001430 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 696749001431 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 696749001432 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 696749001433 putative active site [active] 696749001434 putative substrate binding site [chemical binding]; other site 696749001435 putative cosubstrate binding site; other site 696749001436 catalytic site [active] 696749001437 Gram-negative bacterial tonB protein; Region: TonB; cl10048 696749001438 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 696749001439 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 696749001440 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696749001441 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 696749001442 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 696749001443 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 696749001444 folate binding site [chemical binding]; other site 696749001445 NADP+ binding site [chemical binding]; other site 696749001446 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 696749001447 dimerization interface [polypeptide binding]; other site 696749001448 active site 696749001449 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 696749001450 NRDE protein; Region: NRDE; cl01315 696749001451 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 696749001452 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 696749001453 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 696749001454 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 696749001455 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 696749001456 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 696749001457 Membrane transport protein; Region: Mem_trans; cl09117 696749001458 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 696749001459 active site 696749001460 dimerization interface [polypeptide binding]; other site 696749001461 Sel1 repeat; Region: Sel1; cl02723 696749001462 Sel1 repeat; Region: Sel1; cl02723 696749001463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749001464 S-adenosylmethionine binding site [chemical binding]; other site 696749001465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749001466 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 696749001467 2-isopropylmalate synthase; Validated; Region: PRK03739 696749001468 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 696749001469 active site 696749001470 catalytic residues [active] 696749001471 metal binding site [ion binding]; metal-binding site 696749001472 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 696749001473 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 696749001474 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 696749001475 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 696749001476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749001477 N-terminal plug; other site 696749001478 ligand-binding site [chemical binding]; other site 696749001479 trigger factor; Provisional; Region: tig; PRK01490 696749001480 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749001481 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 696749001482 Clp protease; Region: CLP_protease; pfam00574 696749001483 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 696749001484 oligomer interface [polypeptide binding]; other site 696749001485 active site residues [active] 696749001486 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 696749001487 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 696749001488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749001489 Walker A motif; other site 696749001490 ATP binding site [chemical binding]; other site 696749001491 Walker B motif; other site 696749001492 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 696749001493 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 696749001494 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 696749001495 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 696749001496 Fumarase C-terminus; Region: Fumerase_C; cl00795 696749001497 phosphate acetyltransferase; Reviewed; Region: PRK05632 696749001498 DRTGG domain; Region: DRTGG; cl12147 696749001499 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 696749001500 Acetokinase family; Region: Acetate_kinase; cl01029 696749001501 acetate kinase; Region: ackA; TIGR00016 696749001502 Dehydratase family; Region: ILVD_EDD; cl00340 696749001503 6-phosphogluconate dehydratase; Region: edd; TIGR01196 696749001504 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 696749001505 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 696749001506 active site 696749001507 intersubunit interface [polypeptide binding]; other site 696749001508 catalytic residue [active] 696749001509 GntP family permease; Region: GntP_permease; pfam02447 696749001510 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 696749001511 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 696749001512 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 696749001513 ATP-binding site [chemical binding]; other site 696749001514 Gluconate-6-phosphate binding site [chemical binding]; other site 696749001515 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 696749001516 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749001517 tetrameric interface [polypeptide binding]; other site 696749001518 activator binding site; other site 696749001519 NADP binding site [chemical binding]; other site 696749001520 substrate binding site [chemical binding]; other site 696749001521 catalytic residues [active] 696749001522 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 696749001523 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 696749001524 putative catalytic cysteine [active] 696749001525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749001526 Leucine carboxyl methyltransferase; Region: LCM; cl01306 696749001527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 696749001528 carboxy-terminal protease; Provisional; Region: PRK11186 696749001529 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 696749001530 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 696749001531 protein binding site [polypeptide binding]; other site 696749001532 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 696749001533 Catalytic dyad [active] 696749001534 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 696749001535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 696749001536 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 696749001537 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 696749001538 active site 696749001539 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 696749001540 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 696749001541 active site 696749001542 multimer interface [polypeptide binding]; other site 696749001543 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 696749001544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749001545 FeS/SAM binding site; other site 696749001546 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 696749001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696749001548 TPR motif; other site 696749001549 binding surface 696749001550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 696749001551 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 696749001552 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 696749001553 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 696749001554 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 696749001555 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 696749001556 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 696749001557 dimer interface [polypeptide binding]; other site 696749001558 motif 1; other site 696749001559 active site 696749001560 motif 2; other site 696749001561 motif 3; other site 696749001562 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 696749001563 anticodon binding site; other site 696749001564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 696749001565 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 696749001566 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 696749001567 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 696749001568 Trp docking motif [polypeptide binding]; other site 696749001569 active site 696749001570 GTP-binding protein Der; Reviewed; Region: PRK00093 696749001571 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 696749001572 G1 box; other site 696749001573 GTP/Mg2+ binding site [chemical binding]; other site 696749001574 Switch I region; other site 696749001575 G2 box; other site 696749001576 Switch II region; other site 696749001577 G3 box; other site 696749001578 G4 box; other site 696749001579 G5 box; other site 696749001580 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 696749001581 G1 box; other site 696749001582 GTP/Mg2+ binding site [chemical binding]; other site 696749001583 Switch I region; other site 696749001584 G2 box; other site 696749001585 G3 box; other site 696749001586 Switch II region; other site 696749001587 G4 box; other site 696749001588 G5 box; other site 696749001589 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 696749001590 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 696749001591 putative acyl-acceptor binding pocket; other site 696749001592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749001593 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749001594 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749001595 Predicted membrane protein [Function unknown]; Region: COG4648 696749001596 AMP-binding enzyme; Region: AMP-binding; cl15778 696749001597 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 696749001598 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 696749001599 Ligand binding site; other site 696749001600 Putative Catalytic site; other site 696749001601 DXD motif; other site 696749001602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696749001603 putative acyl-acceptor binding pocket; other site 696749001604 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 696749001605 active sites [active] 696749001606 tetramer interface [polypeptide binding]; other site 696749001607 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696749001608 active site 696749001609 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 696749001610 Predicted exporter [General function prediction only]; Region: COG4258 696749001611 Predicted exporter [General function prediction only]; Region: COG4258 696749001612 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 696749001613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001614 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 696749001615 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696749001616 dimer interface [polypeptide binding]; other site 696749001617 active site 696749001618 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 696749001619 putative active site 1 [active] 696749001620 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749001621 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 696749001622 NAD(P) binding site [chemical binding]; other site 696749001623 homotetramer interface [polypeptide binding]; other site 696749001624 homodimer interface [polypeptide binding]; other site 696749001625 active site 696749001626 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 696749001627 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696749001628 dimer interface [polypeptide binding]; other site 696749001629 active site 696749001630 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 696749001631 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 696749001632 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 696749001633 SecA binding site; other site 696749001634 Preprotein binding site; other site 696749001635 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 696749001636 GSH binding site [chemical binding]; other site 696749001637 catalytic residues [active] 696749001638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 696749001639 active site residue [active] 696749001640 GTPase RsgA; Reviewed; Region: PRK12288 696749001641 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 696749001642 RNA binding site [nucleotide binding]; other site 696749001643 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 696749001644 GTPase/Zn-binding domain interface [polypeptide binding]; other site 696749001645 GTP/Mg2+ binding site [chemical binding]; other site 696749001646 G4 box; other site 696749001647 G5 box; other site 696749001648 G1 box; other site 696749001649 Switch I region; other site 696749001650 G2 box; other site 696749001651 G3 box; other site 696749001652 Switch II region; other site 696749001653 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 696749001654 catalytic site [active] 696749001655 putative active site [active] 696749001656 putative substrate binding site [chemical binding]; other site 696749001657 dimer interface [polypeptide binding]; other site 696749001658 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 696749001659 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 696749001660 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 696749001661 NAD binding site [chemical binding]; other site 696749001662 homotetramer interface [polypeptide binding]; other site 696749001663 homodimer interface [polypeptide binding]; other site 696749001664 substrate binding site [chemical binding]; other site 696749001665 active site 696749001666 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 696749001667 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 696749001668 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 696749001669 Walker A/P-loop; other site 696749001670 ATP binding site [chemical binding]; other site 696749001671 Q-loop/lid; other site 696749001672 ABC transporter signature motif; other site 696749001673 Walker B; other site 696749001674 D-loop; other site 696749001675 H-loop/switch region; other site 696749001676 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696749001677 FtsX-like permease family; Region: FtsX; cl15850 696749001678 macrolide transporter subunit MacA; Provisional; Region: PRK11578 696749001679 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749001680 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749001681 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 696749001682 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 696749001683 Lipopolysaccharide-assembly; Region: LptE; cl01125 696749001684 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 696749001685 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 696749001686 HIGH motif; other site 696749001687 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 696749001688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749001689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749001690 active site 696749001691 KMSKS motif; other site 696749001692 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 696749001693 tRNA binding surface [nucleotide binding]; other site 696749001694 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 696749001695 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 696749001696 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 696749001697 PYR/PP interface [polypeptide binding]; other site 696749001698 dimer interface [polypeptide binding]; other site 696749001699 TPP binding site [chemical binding]; other site 696749001700 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 696749001701 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 696749001702 TPP-binding site [chemical binding]; other site 696749001703 dimer interface [polypeptide binding]; other site 696749001704 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 696749001705 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 696749001706 putative valine binding site [chemical binding]; other site 696749001707 dimer interface [polypeptide binding]; other site 696749001708 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 696749001709 ketol-acid reductoisomerase; Provisional; Region: PRK05479 696749001710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001711 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 696749001712 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 696749001713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749001714 metal binding site [ion binding]; metal-binding site 696749001715 active site 696749001716 I-site; other site 696749001717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 696749001718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749001719 Helix-turn-helix domains; Region: HTH; cl00088 696749001720 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 696749001721 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 696749001722 G1 box; other site 696749001723 putative GEF interaction site [polypeptide binding]; other site 696749001724 GTP/Mg2+ binding site [chemical binding]; other site 696749001725 Switch I region; other site 696749001726 G2 box; other site 696749001727 G3 box; other site 696749001728 Switch II region; other site 696749001729 G4 box; other site 696749001730 G5 box; other site 696749001731 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 696749001732 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 696749001733 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 696749001734 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 696749001735 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 696749001736 active site 696749001737 aconitate hydratase; Validated; Region: PRK09277 696749001738 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 696749001739 substrate binding site [chemical binding]; other site 696749001740 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 696749001741 ligand binding site [chemical binding]; other site 696749001742 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 696749001743 substrate binding site [chemical binding]; other site 696749001744 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 696749001745 homotrimer interaction site [polypeptide binding]; other site 696749001746 putative active site [active] 696749001747 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 696749001748 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 696749001749 putative ATP binding site [chemical binding]; other site 696749001750 putative substrate interface [chemical binding]; other site 696749001751 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749001752 Helix-turn-helix domains; Region: HTH; cl00088 696749001753 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 696749001754 dimerization interface [polypeptide binding]; other site 696749001755 substrate binding pocket [chemical binding]; other site 696749001756 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 696749001757 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696749001758 FMN binding site [chemical binding]; other site 696749001759 active site 696749001760 catalytic residues [active] 696749001761 substrate binding site [chemical binding]; other site 696749001762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749001763 putative substrate translocation pore; other site 696749001764 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 696749001765 homotrimer interaction site [polypeptide binding]; other site 696749001766 putative active site [active] 696749001767 EamA-like transporter family; Region: EamA; cl01037 696749001768 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749001769 EamA-like transporter family; Region: EamA; cl01037 696749001770 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 696749001771 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 696749001772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001773 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 696749001774 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 696749001775 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 696749001776 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 696749001777 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 696749001778 putative NAD(P) binding site [chemical binding]; other site 696749001779 active site 696749001780 Oligomerisation domain; Region: Oligomerisation; cl00519 696749001781 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 696749001782 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 696749001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001784 enoyl-CoA hydratase; Provisional; Region: PRK07509 696749001785 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749001786 substrate binding site [chemical binding]; other site 696749001787 oxyanion hole (OAH) forming residues; other site 696749001788 trimer interface [polypeptide binding]; other site 696749001789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749001790 dimer interface [polypeptide binding]; other site 696749001791 phosphorylation site [posttranslational modification] 696749001792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749001793 ATP binding site [chemical binding]; other site 696749001794 Mg2+ binding site [ion binding]; other site 696749001795 G-X-G motif; other site 696749001796 Response regulator receiver domain; Region: Response_reg; pfam00072 696749001797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749001798 active site 696749001799 phosphorylation site [posttranslational modification] 696749001800 intermolecular recognition site; other site 696749001801 dimerization interface [polypeptide binding]; other site 696749001802 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 696749001803 cysteine synthase B; Region: cysM; TIGR01138 696749001804 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 696749001805 dimer interface [polypeptide binding]; other site 696749001806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749001807 catalytic residue [active] 696749001808 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 696749001809 active site 696749001810 catalytic site [active] 696749001811 substrate binding site [chemical binding]; other site 696749001812 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 696749001813 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 696749001814 TRAM domain; Region: TRAM; cl01282 696749001815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749001816 S-adenosylmethionine binding site [chemical binding]; other site 696749001817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749001818 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 696749001819 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 696749001820 synthetase active site [active] 696749001821 NTP binding site [chemical binding]; other site 696749001822 metal binding site [ion binding]; metal-binding site 696749001823 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 696749001824 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 696749001825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749001826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001827 NAD(P) binding site [chemical binding]; other site 696749001828 active site 696749001829 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 696749001830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 696749001831 homodimer interface [polypeptide binding]; other site 696749001832 metal binding site [ion binding]; metal-binding site 696749001833 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 696749001834 homodimer interface [polypeptide binding]; other site 696749001835 active site 696749001836 putative chemical substrate binding site [chemical binding]; other site 696749001837 metal binding site [ion binding]; metal-binding site 696749001838 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 696749001839 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 696749001840 poly(A) polymerase; Region: pcnB; TIGR01942 696749001841 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 696749001842 active site 696749001843 NTP binding site [chemical binding]; other site 696749001844 metal binding triad [ion binding]; metal-binding site 696749001845 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 696749001846 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 696749001847 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 696749001848 catalytic center binding site [active] 696749001849 ATP binding site [chemical binding]; other site 696749001850 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 696749001851 oligomerization interface [polypeptide binding]; other site 696749001852 active site 696749001853 metal binding site [ion binding]; metal-binding site 696749001854 pantoate--beta-alanine ligase; Region: panC; TIGR00018 696749001855 Pantoate-beta-alanine ligase; Region: PanC; cd00560 696749001856 active site 696749001857 ATP-binding site [chemical binding]; other site 696749001858 pantoate-binding site; other site 696749001859 HXXH motif; other site 696749001860 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 696749001861 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 696749001862 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696749001863 dimerization domain swap beta strand [polypeptide binding]; other site 696749001864 regulatory protein interface [polypeptide binding]; other site 696749001865 active site 696749001866 regulatory phosphorylation site [posttranslational modification]; other site 696749001867 Protein of unknown function (DUF615); Region: DUF615; cl01147 696749001868 acyl-CoA synthetase; Validated; Region: PRK08162 696749001869 AMP-binding enzyme; Region: AMP-binding; cl15778 696749001870 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749001871 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 696749001872 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 696749001873 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 696749001874 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 696749001875 active site 696749001876 dimer interface [polypeptide binding]; other site 696749001877 motif 1; other site 696749001878 motif 2; other site 696749001879 motif 3; other site 696749001880 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 696749001881 anticodon binding site; other site 696749001882 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 696749001883 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 696749001884 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 696749001885 C-terminal domain interface [polypeptide binding]; other site 696749001886 GSH binding site (G-site) [chemical binding]; other site 696749001887 dimer interface [polypeptide binding]; other site 696749001888 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 696749001889 N-terminal domain interface [polypeptide binding]; other site 696749001890 putative dimer interface [polypeptide binding]; other site 696749001891 active site 696749001892 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 696749001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749001894 putative substrate translocation pore; other site 696749001895 H+ Antiporter protein; Region: 2A0121; TIGR00900 696749001896 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 696749001897 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 696749001898 23S rRNA binding site [nucleotide binding]; other site 696749001899 L21 binding site [polypeptide binding]; other site 696749001900 L13 binding site [polypeptide binding]; other site 696749001901 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 696749001902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 696749001903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749001904 Coenzyme A binding pocket [chemical binding]; other site 696749001905 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 696749001906 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 696749001907 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 696749001908 dimer interface [polypeptide binding]; other site 696749001909 motif 1; other site 696749001910 active site 696749001911 motif 2; other site 696749001912 motif 3; other site 696749001913 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 696749001914 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 696749001915 putative tRNA-binding site [nucleotide binding]; other site 696749001916 B3/4 domain; Region: B3_4; cl11458 696749001917 tRNA synthetase B5 domain; Region: B5; cl08394 696749001918 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 696749001919 dimer interface [polypeptide binding]; other site 696749001920 motif 1; other site 696749001921 motif 3; other site 696749001922 motif 2; other site 696749001923 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 696749001924 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696749001925 IHF dimer interface [polypeptide binding]; other site 696749001926 IHF - DNA interface [nucleotide binding]; other site 696749001927 transcription termination factor Rho; Provisional; Region: rho; PRK09376 696749001928 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 696749001929 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 696749001930 RNA binding site [nucleotide binding]; other site 696749001931 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 696749001932 multimer interface [polypeptide binding]; other site 696749001933 Walker A motif; other site 696749001934 ATP binding site [chemical binding]; other site 696749001935 Walker B motif; other site 696749001936 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 696749001937 catalytic residues [active] 696749001938 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 696749001939 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 696749001940 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749001941 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 696749001942 TilS substrate binding domain; Region: TilS; pfam09179 696749001943 B3/4 domain; Region: B3_4; cl11458 696749001944 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 696749001945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749001946 YGGT family; Region: YGGT; cl00508 696749001947 DNA polymerase I; Provisional; Region: PRK05755 696749001948 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 696749001949 active site 696749001950 metal binding site 1 [ion binding]; metal-binding site 696749001951 putative 5' ssDNA interaction site; other site 696749001952 metal binding site 3; metal-binding site 696749001953 metal binding site 2 [ion binding]; metal-binding site 696749001954 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 696749001955 putative DNA binding site [nucleotide binding]; other site 696749001956 putative metal binding site [ion binding]; other site 696749001957 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 696749001958 active site 696749001959 catalytic site [active] 696749001960 substrate binding site [chemical binding]; other site 696749001961 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 696749001962 active site 696749001963 DNA binding site [nucleotide binding] 696749001964 catalytic site [active] 696749001965 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 696749001966 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696749001967 Protein of unknown function (DUF432); Region: DUF432; cl01027 696749001968 type II secretion system protein E; Region: type_II_gspE; TIGR02533 696749001969 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 696749001970 Walker A motif; other site 696749001971 ATP binding site [chemical binding]; other site 696749001972 Walker B motif; other site 696749001973 OsmC-like protein; Region: OsmC; cl00767 696749001974 Helix-turn-helix domains; Region: HTH; cl00088 696749001975 Predicted amidohydrolase [General function prediction only]; Region: COG0388 696749001976 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 696749001977 putative active site [active] 696749001978 catalytic triad [active] 696749001979 dimer interface [polypeptide binding]; other site 696749001980 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 696749001981 anti sigma factor interaction site; other site 696749001982 regulatory phosphorylation site [posttranslational modification]; other site 696749001983 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 696749001984 VacJ like lipoprotein; Region: VacJ; cl01073 696749001985 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 696749001986 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 696749001987 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 696749001988 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 696749001989 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 696749001990 30S subunit binding site; other site 696749001991 BolA-like protein; Region: BolA; cl00386 696749001992 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 696749001993 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 696749001994 hinge; other site 696749001995 active site 696749001996 ATP phosphoribosyltransferase; Region: HisG; cl15266 696749001997 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 696749001998 histidinol dehydrogenase; Region: hisD; TIGR00069 696749001999 NAD binding site [chemical binding]; other site 696749002000 dimerization interface [polypeptide binding]; other site 696749002001 product binding site; other site 696749002002 substrate binding site [chemical binding]; other site 696749002003 zinc binding site [ion binding]; other site 696749002004 catalytic residues [active] 696749002005 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 696749002006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749002007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749002008 homodimer interface [polypeptide binding]; other site 696749002009 catalytic residue [active] 696749002010 chorismate binding enzyme; Region: Chorismate_bind; cl10555 696749002011 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 696749002012 putative active site [active] 696749002013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749002014 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 696749002015 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 696749002016 nudix motif; other site 696749002017 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 696749002018 putative active site [active] 696749002019 putative CoA binding site [chemical binding]; other site 696749002020 nudix motif; other site 696749002021 metal binding site [ion binding]; metal-binding site 696749002022 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 696749002023 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 696749002024 trimer interface [polypeptide binding]; other site 696749002025 putative metal binding site [ion binding]; other site 696749002026 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 696749002027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749002028 Peptidase C13 family; Region: Peptidase_C13; cl02159 696749002029 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749002030 Putative esterase; Region: Esterase; pfam00756 696749002031 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 696749002032 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 696749002033 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 696749002034 substrate binding site [chemical binding]; other site 696749002035 hexamer interface [polypeptide binding]; other site 696749002036 metal binding site [ion binding]; metal-binding site 696749002037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749002038 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 696749002039 active site 696749002040 motif I; other site 696749002041 motif II; other site 696749002042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749002043 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 696749002044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 696749002045 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 696749002046 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 696749002047 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 696749002048 Cation efflux family; Region: Cation_efflux; cl00316 696749002049 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 696749002050 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 696749002051 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 696749002052 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 696749002053 DNA binding site [nucleotide binding] 696749002054 active site 696749002055 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 696749002056 heterotetramer interface [polypeptide binding]; other site 696749002057 active site pocket [active] 696749002058 cleavage site 696749002059 Quinolinate synthetase A protein; Region: NadA; cl00420 696749002060 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 696749002061 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 696749002062 active site 696749002063 purine riboside binding site [chemical binding]; other site 696749002064 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 696749002065 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 696749002066 putative NAD(P) binding site [chemical binding]; other site 696749002067 catalytic Zn binding site [ion binding]; other site 696749002068 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 696749002069 Helix-turn-helix domains; Region: HTH; cl00088 696749002070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749002071 dimerization interface [polypeptide binding]; other site 696749002072 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 696749002073 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749002074 FAD binding site [chemical binding]; other site 696749002075 substrate binding pocket [chemical binding]; other site 696749002076 catalytic base [active] 696749002077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002078 benzoate transport; Region: 2A0115; TIGR00895 696749002079 putative substrate translocation pore; other site 696749002080 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 696749002081 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 696749002082 CoA-transferase family III; Region: CoA_transf_3; pfam02515 696749002083 tricarballylate utilization protein B; Provisional; Region: PRK15033 696749002084 tricarballylate dehydrogenase; Validated; Region: PRK08274 696749002085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002086 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 696749002087 Helix-turn-helix domains; Region: HTH; cl00088 696749002088 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 696749002089 putative dimerization interface [polypeptide binding]; other site 696749002090 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 696749002091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749002092 citrate-proton symporter; Provisional; Region: PRK15075 696749002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002094 putative substrate translocation pore; other site 696749002095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749002096 Helix-turn-helix domains; Region: HTH; cl00088 696749002097 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 696749002098 putative dimerization interface [polypeptide binding]; other site 696749002099 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749002100 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 696749002101 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 696749002102 metal binding site [ion binding]; metal-binding site 696749002103 putative dimer interface [polypeptide binding]; other site 696749002104 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749002105 SurA N-terminal domain; Region: SurA_N_3; cl07813 696749002106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749002107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749002108 Fatty acid desaturase; Region: FA_desaturase; pfam00487 696749002109 LysE type translocator; Region: LysE; cl00565 696749002110 Helix-turn-helix domains; Region: HTH; cl00088 696749002111 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 696749002112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749002113 dimerization interface [polypeptide binding]; other site 696749002114 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 696749002115 methionine synthase; Provisional; Region: PRK01207 696749002116 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 696749002117 substrate binding site [chemical binding]; other site 696749002118 THF binding site; other site 696749002119 zinc-binding site [ion binding]; other site 696749002120 Flavin Reductases; Region: FlaRed; cl00801 696749002121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749002122 Helix-turn-helix domains; Region: HTH; cl00088 696749002123 Restriction endonuclease; Region: Mrr_cat; cl00516 696749002124 AAA domain; Region: AAA_22; pfam13401 696749002125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749002126 Helix-turn-helix domains; Region: HTH; cl00088 696749002127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749002128 dimerization interface [polypeptide binding]; other site 696749002129 hypothetical protein; Provisional; Region: PRK10281 696749002130 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749002131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749002132 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 696749002133 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 696749002134 Trp docking motif [polypeptide binding]; other site 696749002135 putative active site [active] 696749002136 TniQ; Region: TniQ; pfam06527 696749002137 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696749002138 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696749002139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002140 AAA domain; Region: AAA_22; pfam13401 696749002141 Integrase core domain; Region: rve; cl01316 696749002142 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 696749002143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 696749002144 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 696749002145 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696749002146 Active Sites [active] 696749002147 potential frameshift: common BLAST hit: gi|184157020|ref|YP_001845359.1| Signal transduction histidine kinase 696749002148 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 696749002149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749002150 ATP binding site [chemical binding]; other site 696749002151 Mg2+ binding site [ion binding]; other site 696749002152 G-X-G motif; other site 696749002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 696749002154 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 696749002155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 696749002156 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 696749002157 dimer interface [polypeptide binding]; other site 696749002158 putative radical transfer pathway; other site 696749002159 diiron center [ion binding]; other site 696749002160 tyrosyl radical; other site 696749002161 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 696749002162 ATP cone domain; Region: ATP-cone; pfam03477 696749002163 Class I ribonucleotide reductase; Region: RNR_I; cd01679 696749002164 active site 696749002165 dimer interface [polypeptide binding]; other site 696749002166 catalytic residues [active] 696749002167 effector binding site; other site 696749002168 R2 peptide binding site; other site 696749002169 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 696749002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749002171 active site 696749002172 phosphorylation site [posttranslational modification] 696749002173 intermolecular recognition site; other site 696749002174 dimerization interface [polypeptide binding]; other site 696749002175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749002176 DNA binding site [nucleotide binding] 696749002177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 696749002178 dimerization interface [polypeptide binding]; other site 696749002179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749002180 dimer interface [polypeptide binding]; other site 696749002181 phosphorylation site [posttranslational modification] 696749002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749002183 ATP binding site [chemical binding]; other site 696749002184 Mg2+ binding site [ion binding]; other site 696749002185 G-X-G motif; other site 696749002186 MASE1; Region: MASE1; pfam05231 696749002187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749002188 metal binding site [ion binding]; metal-binding site 696749002189 active site 696749002190 I-site; other site 696749002191 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 696749002192 NADH dehydrogenase subunit B; Validated; Region: PRK06411 696749002193 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 696749002194 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 696749002195 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 696749002196 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 696749002197 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 696749002198 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 696749002199 putative dimer interface [polypeptide binding]; other site 696749002200 [2Fe-2S] cluster binding site [ion binding]; other site 696749002201 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 696749002202 SLBB domain; Region: SLBB; pfam10531 696749002203 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 696749002204 NADH dehydrogenase subunit G; Validated; Region: PRK08166 696749002205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749002206 catalytic loop [active] 696749002207 iron binding site [ion binding]; other site 696749002208 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 696749002209 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 696749002210 [4Fe-4S] binding site [ion binding]; other site 696749002211 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 696749002212 NADH dehydrogenase; Region: NADHdh; cl00469 696749002213 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 696749002214 4Fe-4S binding domain; Region: Fer4; cl02805 696749002215 4Fe-4S binding domain; Region: Fer4; cl02805 696749002216 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 696749002217 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 696749002218 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 696749002219 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 696749002220 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 696749002221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 696749002222 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 696749002223 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 696749002224 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 696749002225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749002226 active site 696749002227 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 696749002228 DNA-binding site [nucleotide binding]; DNA binding site 696749002229 RNA-binding motif; other site 696749002230 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 696749002231 Helix-turn-helix domains; Region: HTH; cl00088 696749002232 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 696749002233 putative dimerization interface [polypeptide binding]; other site 696749002234 ferredoxin-NADP reductase; Provisional; Region: PRK10926 696749002235 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 696749002236 FAD binding pocket [chemical binding]; other site 696749002237 FAD binding motif [chemical binding]; other site 696749002238 phosphate binding motif [ion binding]; other site 696749002239 beta-alpha-beta structure motif; other site 696749002240 NAD binding pocket [chemical binding]; other site 696749002241 Conserved TM helix; Region: TM_helix; pfam05552 696749002242 Conserved TM helix; Region: TM_helix; pfam05552 696749002243 Conserved TM helix; Region: TM_helix; pfam05552 696749002244 Conserved TM helix; Region: TM_helix; pfam05552 696749002245 HI0933-like protein; Region: HI0933_like; pfam03486 696749002246 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 696749002247 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 696749002248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749002249 catalytic residue [active] 696749002250 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 696749002251 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749002252 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749002255 putative substrate translocation pore; other site 696749002256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749002257 Helix-turn-helix domains; Region: HTH; cl00088 696749002258 LysE type translocator; Region: LysE; cl00565 696749002259 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 696749002260 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 696749002261 active site 696749002262 HIGH motif; other site 696749002263 KMSKS motif; other site 696749002264 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 696749002265 tRNA binding surface [nucleotide binding]; other site 696749002266 anticodon binding site; other site 696749002267 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 696749002268 dimer interface [polypeptide binding]; other site 696749002269 putative tRNA-binding site [nucleotide binding]; other site 696749002270 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 696749002271 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 696749002272 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 696749002273 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 696749002274 LysE type translocator; Region: LysE; cl00565 696749002275 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 696749002276 trimer interface [polypeptide binding]; other site 696749002277 active site 696749002278 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 696749002279 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696749002280 FMN binding site [chemical binding]; other site 696749002281 active site 696749002282 catalytic residues [active] 696749002283 substrate binding site [chemical binding]; other site 696749002284 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 696749002285 signal recognition particle protein; Provisional; Region: PRK10867 696749002286 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 696749002287 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 696749002288 GTP binding site [chemical binding]; other site 696749002289 Signal peptide binding domain; Region: SRP_SPB; pfam02978 696749002290 Type III pantothenate kinase; Region: Pan_kinase; cl09130 696749002291 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 696749002292 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 696749002293 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 696749002294 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749002295 Transcriptional regulators [Transcription]; Region: GntR; COG1802 696749002296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749002297 DNA-binding site [nucleotide binding]; DNA binding site 696749002298 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 696749002299 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 696749002300 Walker A/P-loop; other site 696749002301 ATP binding site [chemical binding]; other site 696749002302 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 696749002303 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 696749002304 ABC transporter signature motif; other site 696749002305 Walker B; other site 696749002306 D-loop; other site 696749002307 H-loop/switch region; other site 696749002308 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 696749002309 FtsZ protein binding site [polypeptide binding]; other site 696749002310 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 696749002311 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 696749002312 nucleotide binding pocket [chemical binding]; other site 696749002313 K-X-D-G motif; other site 696749002314 catalytic site [active] 696749002315 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 696749002316 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 696749002317 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 696749002318 Dimer interface [polypeptide binding]; other site 696749002319 BRCT sequence motif; other site 696749002320 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 696749002321 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 696749002322 heme binding site [chemical binding]; other site 696749002323 ferroxidase pore; other site 696749002324 ferroxidase diiron center [ion binding]; other site 696749002325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002326 putative substrate translocation pore; other site 696749002327 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 696749002328 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 696749002329 active site 696749002330 homotetramer interface [polypeptide binding]; other site 696749002331 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 696749002332 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749002333 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 696749002334 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749002335 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 696749002336 inhibitor-cofactor binding pocket; inhibition site 696749002337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749002338 catalytic residue [active] 696749002339 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 696749002340 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749002341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749002342 catalytic residue [active] 696749002343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749002344 S-adenosylmethionine binding site [chemical binding]; other site 696749002345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002346 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002347 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 696749002348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696749002349 RNA binding surface [nucleotide binding]; other site 696749002350 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 696749002351 probable active site [active] 696749002352 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 696749002353 ScpA/B protein; Region: ScpA_ScpB; cl00598 696749002354 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 696749002355 Protein of unknown function, DUF462; Region: DUF462; cl01190 696749002356 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 696749002357 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 696749002358 Acyl transferase domain; Region: Acyl_transf_1; cl08282 696749002359 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 696749002360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 696749002361 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 696749002362 NAD(P) binding site [chemical binding]; other site 696749002363 homotetramer interface [polypeptide binding]; other site 696749002364 homodimer interface [polypeptide binding]; other site 696749002365 active site 696749002366 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749002367 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 696749002368 BON domain; Region: BON; cl02771 696749002369 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749002370 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 696749002371 dimer interface [polypeptide binding]; other site 696749002372 substrate binding site [chemical binding]; other site 696749002373 ATP binding site [chemical binding]; other site 696749002374 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 696749002375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749002376 motif II; other site 696749002377 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 696749002378 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 696749002379 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 696749002380 GDYXXLXY protein; Region: GDYXXLXY; cl02066 696749002381 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 696749002382 tetramerization interface [polypeptide binding]; other site 696749002383 active site 696749002384 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 696749002385 putative active site [active] 696749002386 catalytic residue [active] 696749002387 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 696749002388 5S rRNA interface [nucleotide binding]; other site 696749002389 CTC domain interface [polypeptide binding]; other site 696749002390 L16 interface [polypeptide binding]; other site 696749002391 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 696749002392 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 696749002393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749002394 active site 696749002395 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 696749002396 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 696749002397 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 696749002398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696749002399 binding surface 696749002400 TPR motif; other site 696749002401 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 696749002402 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 696749002403 tRNA; other site 696749002404 putative tRNA binding site [nucleotide binding]; other site 696749002405 putative NADP binding site [chemical binding]; other site 696749002406 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 696749002407 DNA primase, catalytic core; Region: dnaG; TIGR01391 696749002408 CHC2 zinc finger; Region: zf-CHC2; cl15369 696749002409 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 696749002410 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 696749002411 active site 696749002412 metal binding site [ion binding]; metal-binding site 696749002413 interdomain interaction site; other site 696749002414 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 696749002415 Outer membrane lipoprotein; Region: YfiO; pfam13525 696749002416 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 696749002417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696749002418 RNA binding surface [nucleotide binding]; other site 696749002419 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696749002420 active site 696749002421 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 696749002422 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749002423 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 696749002424 SmpB-tmRNA interface; other site 696749002425 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 696749002426 active site 696749002427 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 696749002428 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 696749002429 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 696749002430 putative effector binding pocket; other site 696749002431 putative dimerization interface [polypeptide binding]; other site 696749002432 tartrate dehydrogenase; Provisional; Region: PRK08194 696749002433 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 696749002434 BCCT family transporter; Region: BCCT; cl00569 696749002435 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749002436 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 696749002437 substrate binding pocket [chemical binding]; other site 696749002438 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 696749002439 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 696749002440 [2Fe-2S] cluster binding site [ion binding]; other site 696749002441 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 696749002442 putative alpha subunit interface [polypeptide binding]; other site 696749002443 putative active site [active] 696749002444 putative substrate binding site [chemical binding]; other site 696749002445 Fe binding site [ion binding]; other site 696749002446 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749002447 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 696749002448 tetramerization interface [polypeptide binding]; other site 696749002449 NAD(P) binding site [chemical binding]; other site 696749002450 catalytic residues [active] 696749002451 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 696749002452 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 696749002453 FMN-binding pocket [chemical binding]; other site 696749002454 flavin binding motif; other site 696749002455 phosphate binding motif [ion binding]; other site 696749002456 beta-alpha-beta structure motif; other site 696749002457 NAD binding pocket [chemical binding]; other site 696749002458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749002459 catalytic loop [active] 696749002460 iron binding site [ion binding]; other site 696749002461 NAD synthetase; Provisional; Region: PRK13981 696749002462 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 696749002463 multimer interface [polypeptide binding]; other site 696749002464 active site 696749002465 catalytic triad [active] 696749002466 protein interface 1 [polypeptide binding]; other site 696749002467 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 696749002468 homodimer interface [polypeptide binding]; other site 696749002469 NAD binding pocket [chemical binding]; other site 696749002470 ATP binding pocket [chemical binding]; other site 696749002471 Mg binding site [ion binding]; other site 696749002472 active-site loop [active] 696749002473 Pirin-related protein [General function prediction only]; Region: COG1741 696749002474 Cupin domain; Region: Cupin_2; cl09118 696749002475 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 696749002476 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 696749002477 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 696749002478 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696749002479 dimer interface [polypeptide binding]; other site 696749002480 active site 696749002481 EcsC protein family; Region: EcsC; pfam12787 696749002482 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 696749002483 S17 interaction site [polypeptide binding]; other site 696749002484 S8 interaction site; other site 696749002485 16S rRNA interaction site [nucleotide binding]; other site 696749002486 streptomycin interaction site [chemical binding]; other site 696749002487 23S rRNA interaction site [nucleotide binding]; other site 696749002488 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 696749002489 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 696749002490 elongation factor G; Reviewed; Region: PRK00007 696749002491 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 696749002492 G1 box; other site 696749002493 putative GEF interaction site [polypeptide binding]; other site 696749002494 GTP/Mg2+ binding site [chemical binding]; other site 696749002495 Switch I region; other site 696749002496 G2 box; other site 696749002497 G3 box; other site 696749002498 Switch II region; other site 696749002499 G4 box; other site 696749002500 G5 box; other site 696749002501 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 696749002502 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 696749002503 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 696749002504 elongation factor Tu; Reviewed; Region: PRK00049 696749002505 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 696749002506 G1 box; other site 696749002507 GEF interaction site [polypeptide binding]; other site 696749002508 GTP/Mg2+ binding site [chemical binding]; other site 696749002509 Switch I region; other site 696749002510 G2 box; other site 696749002511 G3 box; other site 696749002512 Switch II region; other site 696749002513 G4 box; other site 696749002514 G5 box; other site 696749002515 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 696749002516 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 696749002517 Antibiotic Binding Site [chemical binding]; other site 696749002518 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749002519 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749002520 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749002521 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749002522 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 696749002523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749002524 Coenzyme A binding pocket [chemical binding]; other site 696749002525 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 696749002526 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749002527 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749002528 thioredoxin reductase; Provisional; Region: PRK10262 696749002529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749002530 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 696749002531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002532 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 696749002533 LysE type translocator; Region: LysE; cl00565 696749002534 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 696749002535 Septum formation topological specificity factor MinE; Region: MinE; cl00538 696749002536 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 696749002537 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 696749002538 Switch I; other site 696749002539 Switch II; other site 696749002540 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 696749002541 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 696749002542 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 696749002543 putative acyl-acceptor binding pocket; other site 696749002544 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749002545 ligand binding site [chemical binding]; other site 696749002546 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 696749002547 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002548 Family description; Region: UvrD_C_2; cl15862 696749002549 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 696749002550 trimer interface [polypeptide binding]; other site 696749002551 active site 696749002552 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 696749002553 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 696749002554 active site 696749002555 substrate binding site [chemical binding]; other site 696749002556 metal binding site [ion binding]; metal-binding site 696749002557 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 696749002558 feedback inhibition sensing region; other site 696749002559 homohexameric interface [polypeptide binding]; other site 696749002560 nucleotide binding site [chemical binding]; other site 696749002561 N-acetyl-L-glutamate binding site [chemical binding]; other site 696749002562 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749002563 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 696749002564 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 696749002565 putative dimer interface [polypeptide binding]; other site 696749002566 putative active site [active] 696749002567 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 696749002568 octamerization interface [polypeptide binding]; other site 696749002569 diferric-oxygen binding site [ion binding]; other site 696749002570 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749002571 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749002572 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 696749002573 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 696749002574 ferric uptake regulator; Provisional; Region: fur; PRK09462 696749002575 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 696749002576 metal binding site 2 [ion binding]; metal-binding site 696749002577 putative DNA binding helix; other site 696749002578 metal binding site 1 [ion binding]; metal-binding site 696749002579 dimer interface [polypeptide binding]; other site 696749002580 structural Zn2+ binding site [ion binding]; other site 696749002581 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 696749002582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002583 Walker A motif; other site 696749002584 ATP binding site [chemical binding]; other site 696749002585 Walker B motif; other site 696749002586 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 696749002587 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 696749002588 Walker A motif; other site 696749002589 ATP binding site [chemical binding]; other site 696749002590 Walker B motif; other site 696749002591 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 696749002592 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696749002593 catalytic residue [active] 696749002594 exonuclease SbcC; Region: sbcc; TIGR00618 696749002595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002596 Walker A/P-loop; other site 696749002597 ATP binding site [chemical binding]; other site 696749002598 Q-loop/lid; other site 696749002599 exonuclease subunit SbcC; Provisional; Region: PRK10246 696749002600 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 696749002601 ABC transporter signature motif; other site 696749002602 Walker B; other site 696749002603 D-loop; other site 696749002604 H-loop/switch region; other site 696749002605 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696749002606 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 696749002607 active site 696749002608 metal binding site [ion binding]; metal-binding site 696749002609 DNA binding site [nucleotide binding] 696749002610 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 696749002611 OsmC-like protein; Region: OsmC; cl00767 696749002612 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 696749002613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696749002614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002615 TIGR01777 family protein; Region: yfcH 696749002616 NAD(P) binding site [chemical binding]; other site 696749002617 active site 696749002618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002619 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 696749002620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002621 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 696749002622 dimer interface [polypeptide binding]; other site 696749002623 allosteric magnesium binding site [ion binding]; other site 696749002624 active site 696749002625 aspartate-rich active site metal binding site; other site 696749002626 Schiff base residues; other site 696749002627 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749002628 CoenzymeA binding site [chemical binding]; other site 696749002629 subunit interaction site [polypeptide binding]; other site 696749002630 PHB binding site; other site 696749002631 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 696749002632 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749002633 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749002636 putative substrate translocation pore; other site 696749002637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002638 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 696749002639 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 696749002640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002641 AAA domain; Region: AAA_21; pfam13304 696749002642 Walker A/P-loop; other site 696749002643 ATP binding site [chemical binding]; other site 696749002644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002645 Walker B motif; other site 696749002646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749002647 outer membrane porin, OprD family; Region: OprD; pfam03573 696749002648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002649 benzoate transport; Region: 2A0115; TIGR00895 696749002650 putative substrate translocation pore; other site 696749002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002652 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 696749002653 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 696749002654 inhibitor site; inhibition site 696749002655 active site 696749002656 dimer interface [polypeptide binding]; other site 696749002657 catalytic residue [active] 696749002658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749002659 Helix-turn-helix domains; Region: HTH; cl00088 696749002660 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 696749002661 putative dimerization interface [polypeptide binding]; other site 696749002662 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 696749002663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 696749002664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749002665 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 696749002666 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 696749002667 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 696749002668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002669 Predicted dehydrogenase [General function prediction only]; Region: COG0579 696749002670 choline dehydrogenase; Validated; Region: PRK02106 696749002671 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 696749002672 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749002673 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 696749002674 tetrameric interface [polypeptide binding]; other site 696749002675 NAD binding site [chemical binding]; other site 696749002676 catalytic residues [active] 696749002677 transcriptional regulator BetI; Validated; Region: PRK00767 696749002678 Helix-turn-helix domains; Region: HTH; cl00088 696749002679 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 696749002680 BCCT family transporter; Region: BCCT; cl00569 696749002681 BCCT family transporter; Region: BCCT; cl00569 696749002682 MarC family integral membrane protein; Region: MarC; cl00919 696749002683 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 696749002684 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 696749002685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002686 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749002687 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749002688 YaeQ protein; Region: YaeQ; cl01913 696749002689 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749002690 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 696749002691 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 696749002692 putative active site [active] 696749002693 putative metal binding site [ion binding]; other site 696749002694 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 696749002695 N-glycosyltransferase; Provisional; Region: PRK11204 696749002696 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 696749002697 DXD motif; other site 696749002698 PgaD-like protein; Region: PgaD; cl14676 696749002699 enoyl-CoA hydratase; Provisional; Region: PRK06563 696749002700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749002701 substrate binding site [chemical binding]; other site 696749002702 oxyanion hole (OAH) forming residues; other site 696749002703 trimer interface [polypeptide binding]; other site 696749002704 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 696749002705 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749002706 Helix-turn-helix domains; Region: HTH; cl00088 696749002707 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749002708 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 696749002709 [2Fe-2S] cluster binding site [ion binding]; other site 696749002710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 696749002711 hydrophobic ligand binding site; other site 696749002712 short chain dehydrogenase; Provisional; Region: PRK12939 696749002713 classical (c) SDRs; Region: SDR_c; cd05233 696749002714 NAD(P) binding site [chemical binding]; other site 696749002715 active site 696749002716 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 696749002717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696749002718 putative active site [active] 696749002719 putative metal binding site [ion binding]; other site 696749002720 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 696749002721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749002722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002723 D-galactonate transporter; Region: 2A0114; TIGR00893 696749002724 putative substrate translocation pore; other site 696749002725 Cupin domain; Region: Cupin_2; cl09118 696749002726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749002727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749002728 short chain dehydrogenase; Provisional; Region: PRK07062 696749002729 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 696749002730 putative NAD(P) binding site [chemical binding]; other site 696749002731 putative active site [active] 696749002732 L-aspartate dehydrogenase; Provisional; Region: PRK13303 696749002733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002734 Domain of unknown function DUF108; Region: DUF108; pfam01958 696749002735 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749002736 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 696749002737 NAD(P) binding site [chemical binding]; other site 696749002738 catalytic residues [active] 696749002739 hypothetical protein; Provisional; Region: PRK07064 696749002740 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 696749002741 PYR/PP interface [polypeptide binding]; other site 696749002742 dimer interface [polypeptide binding]; other site 696749002743 TPP binding site [chemical binding]; other site 696749002744 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 696749002745 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 696749002746 TPP-binding site [chemical binding]; other site 696749002747 metabolite-proton symporter; Region: 2A0106; TIGR00883 696749002748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002749 putative substrate translocation pore; other site 696749002750 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 696749002751 active site 696749002752 catalytic residues [active] 696749002753 metal binding site [ion binding]; metal-binding site 696749002754 Glutaminase; Region: Glutaminase; cl00907 696749002755 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 696749002756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002757 putative substrate translocation pore; other site 696749002758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749002759 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 696749002760 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 696749002761 active site 696749002762 catalytic residues [active] 696749002763 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 696749002764 Helix-turn-helix domains; Region: HTH; cl00088 696749002765 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 696749002766 dimerization interface [polypeptide binding]; other site 696749002767 substrate binding pocket [chemical binding]; other site 696749002768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749002769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749002770 NAD(P) binding site [chemical binding]; other site 696749002771 active site 696749002772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749002773 D-galactonate transporter; Region: 2A0114; TIGR00893 696749002774 putative substrate translocation pore; other site 696749002775 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 696749002776 TPP-binding site [chemical binding]; other site 696749002777 dimer interface [polypeptide binding]; other site 696749002778 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 696749002779 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 696749002780 PYR/PP interface [polypeptide binding]; other site 696749002781 dimer interface [polypeptide binding]; other site 696749002782 TPP binding site [chemical binding]; other site 696749002783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696749002784 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 696749002785 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 696749002786 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 696749002787 substrate binding pocket [chemical binding]; other site 696749002788 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 696749002789 B12 binding site [chemical binding]; other site 696749002790 cobalt ligand [ion binding]; other site 696749002791 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 696749002792 Phosphate transporter family; Region: PHO4; cl00396 696749002793 Phosphate transporter family; Region: PHO4; cl00396 696749002794 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 696749002795 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 696749002796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749002797 catalytic residue [active] 696749002798 Uncharacterized conserved protein [Function unknown]; Region: COG1262 696749002799 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 696749002800 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 696749002801 Sulfatase; Region: Sulfatase; cl10460 696749002802 Rhomboid family; Region: Rhomboid; cl11446 696749002803 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 696749002804 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 696749002805 NifU-like domain; Region: NifU; cl00484 696749002806 outer membrane receptor FepA; Provisional; Region: PRK13524 696749002807 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749002808 N-terminal plug; other site 696749002809 ligand-binding site [chemical binding]; other site 696749002810 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 696749002811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749002812 nucleophilic elbow; other site 696749002813 catalytic triad; other site 696749002814 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 696749002815 active site clefts [active] 696749002816 zinc binding site [ion binding]; other site 696749002817 dimer interface [polypeptide binding]; other site 696749002818 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 696749002819 active site 696749002820 catalytic triad [active] 696749002821 oxyanion hole [active] 696749002822 switch loop; other site 696749002823 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 696749002824 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 696749002825 Walker A/P-loop; other site 696749002826 ATP binding site [chemical binding]; other site 696749002827 Q-loop/lid; other site 696749002828 ABC transporter signature motif; other site 696749002829 Walker B; other site 696749002830 D-loop; other site 696749002831 H-loop/switch region; other site 696749002832 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 696749002833 FtsX-like permease family; Region: FtsX; cl15850 696749002834 FtsX-like permease family; Region: FtsX; cl15850 696749002835 Rhomboid family; Region: Rhomboid; cl11446 696749002836 Transglycosylase; Region: Transgly; cl07896 696749002837 polyphosphate kinase; Provisional; Region: PRK05443 696749002838 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 696749002839 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 696749002840 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 696749002841 putative active site [active] 696749002842 catalytic site [active] 696749002843 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 696749002844 putative active site [active] 696749002845 putative domain interface [polypeptide binding]; other site 696749002846 catalytic site [active] 696749002847 Sporulation related domain; Region: SPOR; cl10051 696749002848 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 696749002849 Helix-turn-helix domains; Region: HTH; cl00088 696749002850 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 696749002851 dimerization interface [polypeptide binding]; other site 696749002852 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 696749002853 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749002854 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 696749002855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749002856 Rubredoxin [Energy production and conversion]; Region: COG1773 696749002857 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 696749002858 iron binding site [ion binding]; other site 696749002859 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 696749002860 putative hydrophobic ligand binding site [chemical binding]; other site 696749002861 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 696749002862 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 696749002863 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 696749002864 dimer interface [polypeptide binding]; other site 696749002865 putative anticodon binding site; other site 696749002866 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 696749002867 motif 1; other site 696749002868 active site 696749002869 motif 2; other site 696749002870 motif 3; other site 696749002871 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 696749002872 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 696749002873 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696749002874 Active Sites [active] 696749002875 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 696749002876 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 696749002877 CysD dimerization site [polypeptide binding]; other site 696749002878 G1 box; other site 696749002879 putative GEF interaction site [polypeptide binding]; other site 696749002880 GTP/Mg2+ binding site [chemical binding]; other site 696749002881 Switch I region; other site 696749002882 G2 box; other site 696749002883 G3 box; other site 696749002884 Switch II region; other site 696749002885 G4 box; other site 696749002886 G5 box; other site 696749002887 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 696749002888 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 696749002889 Probable chromatin-remodeling complex ATPase chain; Provisional; Region: PLN03142 696749002890 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 696749002891 Citrate transporter; Region: CitMHS; pfam03600 696749002892 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 696749002893 transmembrane helices; other site 696749002894 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 696749002895 Domain of unknown function DUF21; Region: DUF21; pfam01595 696749002896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696749002897 Transporter associated domain; Region: CorC_HlyC; cl08393 696749002898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749002899 Helix-turn-helix domains; Region: HTH; cl00088 696749002900 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 696749002901 substrate binding pocket [chemical binding]; other site 696749002902 dimerization interface [polypeptide binding]; other site 696749002903 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 696749002904 tetramer interface [polypeptide binding]; other site 696749002905 active site 696749002906 Mg2+/Mn2+ binding site [ion binding]; other site 696749002907 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 696749002908 NlpE N-terminal domain; Region: NlpE; cl01138 696749002909 UreD urease accessory protein; Region: UreD; cl00530 696749002910 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 696749002911 alpha-gamma subunit interface [polypeptide binding]; other site 696749002912 beta-gamma subunit interface [polypeptide binding]; other site 696749002913 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 696749002914 gamma-beta subunit interface [polypeptide binding]; other site 696749002915 alpha-beta subunit interface [polypeptide binding]; other site 696749002916 urease subunit alpha; Reviewed; Region: ureC; PRK13207 696749002917 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 696749002918 subunit interactions [polypeptide binding]; other site 696749002919 active site 696749002920 flap region; other site 696749002921 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 696749002922 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 696749002923 dimer interface [polypeptide binding]; other site 696749002924 catalytic residues [active] 696749002925 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 696749002926 UreF; Region: UreF; pfam01730 696749002927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749002928 HupE / UreJ protein; Region: HupE_UreJ; cl01011 696749002929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 696749002930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749002931 S-adenosylmethionine binding site [chemical binding]; other site 696749002932 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 696749002933 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 696749002934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749002935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 696749002936 adenylate kinase; Reviewed; Region: adk; PRK00279 696749002937 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 696749002938 AMP-binding site [chemical binding]; other site 696749002939 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 696749002940 endonuclease III; Provisional; Region: PRK10702 696749002941 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 696749002942 minor groove reading motif; other site 696749002943 helix-hairpin-helix signature motif; other site 696749002944 substrate binding pocket [chemical binding]; other site 696749002945 active site 696749002946 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 696749002947 electron transport complex protein RnfB; Provisional; Region: PRK05113 696749002948 Putative Fe-S cluster; Region: FeS; pfam04060 696749002949 4Fe-4S binding domain; Region: Fer4; cl02805 696749002950 glutamate dehydrogenase; Provisional; Region: PRK09414 696749002951 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 696749002952 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 696749002953 NAD(P) binding site [chemical binding]; other site 696749002954 META domain; Region: META; cl01245 696749002955 META domain; Region: META; cl01245 696749002956 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 696749002957 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 696749002958 putative active site [active] 696749002959 metal binding site [ion binding]; metal-binding site 696749002960 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 696749002961 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 696749002962 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 696749002963 Found in ATP-dependent protease La (LON); Region: LON; smart00464 696749002964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749002965 Walker A motif; other site 696749002966 ATP binding site [chemical binding]; other site 696749002967 Walker B motif; other site 696749002968 arginine finger; other site 696749002969 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 696749002970 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 696749002971 Haemagglutinin; Region: HIM; pfam05662 696749002972 Haemagglutinin; Region: HIM; pfam05662 696749002973 Haemagglutinin; Region: HIM; pfam05662 696749002974 Spc7 kinetochore protein; Region: Spc7; smart00787 696749002975 Haemagglutinin; Region: HIM; pfam05662 696749002976 Haemagglutinin; Region: HIM; pfam05662 696749002977 YadA-like C-terminal region; Region: YadA; pfam03895 696749002978 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 696749002979 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749002980 ligand binding site [chemical binding]; other site 696749002981 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 696749002982 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749002983 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 696749002984 AAA domain; Region: AAA_24; pfam13479 696749002985 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 696749002986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749002987 non-specific DNA binding site [nucleotide binding]; other site 696749002988 salt bridge; other site 696749002989 Predicted transcriptional regulator [Transcription]; Region: COG2932 696749002990 sequence-specific DNA binding site [nucleotide binding]; other site 696749002991 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749002992 Catalytic site [active] 696749002993 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 696749002994 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 696749002995 putative active site [active] 696749002996 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 696749002997 Terminase-like family; Region: Terminase_6; pfam03237 696749002998 Phage terminase large subunit; Region: Terminase_3; cl12054 696749002999 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 696749003000 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 696749003001 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 696749003002 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 696749003003 HeH/LEM domain; Region: HeH; pfam12949 696749003004 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 696749003005 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 696749003006 Bacterial SH3 domain; Region: SH3_3; cl02551 696749003007 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 696749003008 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 696749003009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749003010 non-specific DNA binding site [nucleotide binding]; other site 696749003011 salt bridge; other site 696749003012 sequence-specific DNA binding site [nucleotide binding]; other site 696749003013 tape measure domain; Region: tape_meas_nterm; TIGR02675 696749003014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 696749003015 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 696749003016 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 696749003017 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 696749003018 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696749003019 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749003020 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749003021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749003022 Sulfatase; Region: Sulfatase; cl10460 696749003023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749003024 active site 696749003025 Int/Topo IB signature motif; other site 696749003026 DNA binding site [nucleotide binding] 696749003027 Cell division protein ZapA; Region: ZapA; cl01146 696749003028 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 696749003029 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 696749003030 proline aminopeptidase P II; Provisional; Region: PRK10879 696749003031 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 696749003032 active site 696749003033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003034 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 696749003035 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 696749003036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003037 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 696749003038 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696749003039 DNA binding residues [nucleotide binding] 696749003040 Cation efflux family; Region: Cation_efflux; cl00316 696749003041 LysE type translocator; Region: LysE; cl00565 696749003042 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 696749003043 Helix-turn-helix domains; Region: HTH; cl00088 696749003044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749003045 dimerization interface [polypeptide binding]; other site 696749003046 NMT1-like family; Region: NMT1_2; cl15260 696749003047 Predicted methyltransferases [General function prediction only]; Region: COG0313 696749003048 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 696749003049 Restriction endonuclease; Region: Mrr_cat; cl00516 696749003050 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 696749003051 BON domain; Region: BON; cl02771 696749003052 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749003053 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 696749003054 substrate binding pocket [chemical binding]; other site 696749003055 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749003056 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 696749003057 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 696749003058 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 696749003059 putative NADH binding site [chemical binding]; other site 696749003060 putative active site [active] 696749003061 nudix motif; other site 696749003062 putative metal binding site [ion binding]; other site 696749003063 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 696749003064 RNA/DNA hybrid binding site [nucleotide binding]; other site 696749003065 active site 696749003066 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 696749003067 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 696749003068 active site 696749003069 catalytic site [active] 696749003070 substrate binding site [chemical binding]; other site 696749003071 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 696749003072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749003073 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749003074 catalytic residue [active] 696749003075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749003076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749003077 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 696749003078 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 696749003079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 696749003080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749003081 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 696749003082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749003083 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 696749003084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749003085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 696749003086 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 696749003087 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 696749003088 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 696749003089 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 696749003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003091 dimer interface [polypeptide binding]; other site 696749003092 conserved gate region; other site 696749003093 ABC-ATPase subunit interface; other site 696749003094 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 696749003095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003096 dimer interface [polypeptide binding]; other site 696749003097 conserved gate region; other site 696749003098 putative PBP binding loops; other site 696749003099 ABC-ATPase subunit interface; other site 696749003100 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 696749003101 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 696749003102 Walker A/P-loop; other site 696749003103 ATP binding site [chemical binding]; other site 696749003104 Q-loop/lid; other site 696749003105 ABC transporter signature motif; other site 696749003106 Walker B; other site 696749003107 D-loop; other site 696749003108 H-loop/switch region; other site 696749003109 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 696749003110 Walker A/P-loop; other site 696749003111 ATP binding site [chemical binding]; other site 696749003112 Q-loop/lid; other site 696749003113 ABC transporter signature motif; other site 696749003114 Walker B; other site 696749003115 D-loop; other site 696749003116 H-loop/switch region; other site 696749003117 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 696749003118 putative active site [active] 696749003119 putative FMN binding site [chemical binding]; other site 696749003120 putative substrate binding site [chemical binding]; other site 696749003121 putative catalytic residue [active] 696749003122 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749003123 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749003124 N-terminal plug; other site 696749003125 ligand-binding site [chemical binding]; other site 696749003126 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 696749003127 dimer interface [polypeptide binding]; other site 696749003128 catalytic site [active] 696749003129 putative active site [active] 696749003130 putative substrate binding site [chemical binding]; other site 696749003131 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 696749003132 active site 696749003133 substrate binding pocket [chemical binding]; other site 696749003134 dimer interface [polypeptide binding]; other site 696749003135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749003136 metal binding site [ion binding]; metal-binding site 696749003137 active site 696749003138 I-site; other site 696749003139 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 696749003140 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 696749003141 ANP binding site [chemical binding]; other site 696749003142 Substrate Binding Site II [chemical binding]; other site 696749003143 Substrate Binding Site I [chemical binding]; other site 696749003144 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 696749003145 active site 696749003146 FMN binding site [chemical binding]; other site 696749003147 2,4-decadienoyl-CoA binding site; other site 696749003148 catalytic residue [active] 696749003149 4Fe-4S cluster binding site [ion binding]; other site 696749003150 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 696749003151 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 696749003152 Peptidase family M48; Region: Peptidase_M48; cl12018 696749003153 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 696749003154 NMT1-like family; Region: NMT1_2; cl15260 696749003155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749003156 Helix-turn-helix domains; Region: HTH; cl00088 696749003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 696749003158 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 696749003159 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 696749003160 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 696749003161 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 696749003162 DDE domain; Region: DDE_Tnp_IS240; pfam13610 696749003163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 696749003164 Integrase core domain; Region: rve; cl01316 696749003165 Integrase core domain; Region: rve; cl01316 696749003166 putative mercuric reductase; Provisional; Region: PRK13748 696749003167 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696749003168 metal-binding site [ion binding] 696749003169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749003170 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696749003171 Integrase core domain; Region: rve; cl01316 696749003172 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 696749003173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749003174 Walker A motif; other site 696749003175 ATP binding site [chemical binding]; other site 696749003176 Walker B motif; other site 696749003177 arginine finger; other site 696749003178 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 696749003179 dihydropteroate synthase; Region: DHPS; TIGR01496 696749003180 substrate binding pocket [chemical binding]; other site 696749003181 dimer interface [polypeptide binding]; other site 696749003182 inhibitor binding site; inhibition site 696749003183 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 696749003184 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749003185 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 696749003186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749003187 Coenzyme A binding pocket [chemical binding]; other site 696749003188 aminoglycoside resistance protein; Provisional; Region: PRK13746 696749003189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 696749003190 Integrase core domain; Region: rve; cl01316 696749003191 Integrase core domain; Region: rve; cl01316 696749003192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 696749003193 Integrase core domain; Region: rve; cl01316 696749003194 Integrase core domain; Region: rve; cl01316 696749003195 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 696749003196 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 696749003197 FAD binding site [chemical binding]; other site 696749003198 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 696749003199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003200 oligomerization interface [polypeptide binding]; other site 696749003201 active site 696749003202 NAD+ binding site [chemical binding]; other site 696749003203 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 696749003204 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749003205 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 696749003206 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749003207 active site 696749003208 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 696749003209 lipoyl synthase; Provisional; Region: PRK05481 696749003210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749003211 FeS/SAM binding site; other site 696749003212 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 696749003213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749003215 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696749003216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749003217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749003218 putative substrate translocation pore; other site 696749003219 nitrate transmembrane transporter; Provisional; Region: PLN00028 696749003220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749003221 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749003222 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 696749003223 active site 696749003224 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 696749003225 rRNA interaction site [nucleotide binding]; other site 696749003226 S8 interaction site; other site 696749003227 putative laminin-1 binding site; other site 696749003228 elongation factor Ts; Provisional; Region: tsf; PRK09377 696749003229 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 696749003230 Elongation factor TS; Region: EF_TS; pfam00889 696749003231 Elongation factor TS; Region: EF_TS; pfam00889 696749003232 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 696749003233 Cupin domain; Region: Cupin_2; cl09118 696749003234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003235 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749003236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003237 AzlC protein; Region: AzlC; cl00570 696749003238 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 696749003239 Protein of unknown function (DUF962); Region: DUF962; cl01879 696749003240 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 696749003241 Transglycosylase SLT domain; Region: SLT_2; pfam13406 696749003242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749003243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749003244 catalytic residue [active] 696749003245 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 696749003246 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 696749003247 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 696749003248 ABC-2 type transporter; Region: ABC2_membrane; cl11417 696749003249 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 696749003250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749003251 Walker A/P-loop; other site 696749003252 ATP binding site [chemical binding]; other site 696749003253 Q-loop/lid; other site 696749003254 ABC transporter signature motif; other site 696749003255 Walker B; other site 696749003256 D-loop; other site 696749003257 H-loop/switch region; other site 696749003258 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 696749003259 exodeoxyribonuclease X; Provisional; Region: PRK07983 696749003260 active site 696749003261 catalytic site [active] 696749003262 substrate binding site [chemical binding]; other site 696749003263 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 696749003264 Secretory lipase; Region: LIP; pfam03583 696749003265 Family of unknown function (DUF695); Region: DUF695; pfam05117 696749003266 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 696749003267 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 696749003268 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 696749003269 dimer interface [polypeptide binding]; other site 696749003270 active site 696749003271 glycine-pyridoxal phosphate binding site [chemical binding]; other site 696749003272 folate binding site [chemical binding]; other site 696749003273 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 696749003274 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 696749003275 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 696749003276 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749003277 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749003278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749003279 Helix-turn-helix domains; Region: HTH; cl00088 696749003280 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 696749003281 putative effector binding pocket; other site 696749003282 putative dimerization interface [polypeptide binding]; other site 696749003283 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 696749003284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749003285 substrate binding pocket [chemical binding]; other site 696749003286 membrane-bound complex binding site; other site 696749003287 hinge residues; other site 696749003288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003289 dimer interface [polypeptide binding]; other site 696749003290 conserved gate region; other site 696749003291 putative PBP binding loops; other site 696749003292 ABC-ATPase subunit interface; other site 696749003293 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696749003294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003295 dimer interface [polypeptide binding]; other site 696749003296 conserved gate region; other site 696749003297 putative PBP binding loops; other site 696749003298 ABC-ATPase subunit interface; other site 696749003299 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 696749003300 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 696749003301 Walker A/P-loop; other site 696749003302 ATP binding site [chemical binding]; other site 696749003303 Q-loop/lid; other site 696749003304 ABC transporter signature motif; other site 696749003305 Walker B; other site 696749003306 D-loop; other site 696749003307 H-loop/switch region; other site 696749003308 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 696749003309 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 696749003310 putative protease; Provisional; Region: PRK15452 696749003311 Peptidase family U32; Region: Peptidase_U32; cl03113 696749003312 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749003313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749003314 DNA-binding site [nucleotide binding]; DNA binding site 696749003315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749003316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749003317 homodimer interface [polypeptide binding]; other site 696749003318 catalytic residue [active] 696749003319 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 696749003320 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 696749003321 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 696749003322 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 696749003323 FAD binding pocket [chemical binding]; other site 696749003324 FAD binding motif [chemical binding]; other site 696749003325 phosphate binding motif [ion binding]; other site 696749003326 beta-alpha-beta structure motif; other site 696749003327 NAD binding pocket [chemical binding]; other site 696749003328 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 696749003329 homodimer interaction site [polypeptide binding]; other site 696749003330 cofactor binding site; other site 696749003331 Predicted membrane protein [Function unknown]; Region: COG3174 696749003332 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 696749003333 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 696749003334 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 696749003335 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 696749003336 Walker A motif; other site 696749003337 ATP binding site [chemical binding]; other site 696749003338 Walker B motif; other site 696749003339 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 696749003340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 696749003341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749003342 active site 696749003343 phosphorylation site [posttranslational modification] 696749003344 intermolecular recognition site; other site 696749003345 dimerization interface [polypeptide binding]; other site 696749003346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749003347 DNA binding site [nucleotide binding] 696749003348 sensor protein QseC; Provisional; Region: PRK10337 696749003349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749003350 dimer interface [polypeptide binding]; other site 696749003351 phosphorylation site [posttranslational modification] 696749003352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749003353 ATP binding site [chemical binding]; other site 696749003354 Mg2+ binding site [ion binding]; other site 696749003355 G-X-G motif; other site 696749003356 Hemin uptake protein hemP; Region: hemP; cl10043 696749003357 hypothetical protein; Provisional; Region: PRK08999 696749003358 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 696749003359 active site 696749003360 8-oxo-dGMP binding site [chemical binding]; other site 696749003361 nudix motif; other site 696749003362 metal binding site [ion binding]; metal-binding site 696749003363 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 696749003364 active site 696749003365 pyrophosphate binding site [ion binding]; other site 696749003366 thiamine phosphate binding site [chemical binding]; other site 696749003367 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 696749003368 Transglycosylase; Region: Transgly; cl07896 696749003369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749003370 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 696749003371 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 696749003372 hypothetical protein; Validated; Region: PRK09071 696749003373 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 696749003374 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 696749003375 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749003376 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749003377 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749003378 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749003379 active site 696749003380 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749003381 Chorismate mutase type II; Region: CM_2; cl00693 696749003382 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 696749003383 Prephenate dehydratase; Region: PDT; pfam00800 696749003384 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 696749003385 putative L-Phe binding site [chemical binding]; other site 696749003386 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 696749003387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003388 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 696749003389 hinge; other site 696749003390 active site 696749003391 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 696749003392 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 696749003393 metal binding site [ion binding]; metal-binding site 696749003394 dimer interface [polypeptide binding]; other site 696749003395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749003396 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 696749003397 Protein of unknown function (DUF328); Region: DUF328; cl01143 696749003398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749003399 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 696749003400 ThiS interaction site; other site 696749003401 putative active site [active] 696749003402 tetramer interface [polypeptide binding]; other site 696749003403 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 696749003404 thiS-thiF/thiG interaction site; other site 696749003405 Protein of unknown function (DUF423); Region: DUF423; cl01008 696749003406 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 696749003407 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 696749003408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696749003409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696749003410 DNA binding residues [nucleotide binding] 696749003411 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 696749003412 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 696749003413 DNA-binding site [nucleotide binding]; DNA binding site 696749003414 RNA-binding motif; other site 696749003415 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 696749003416 DEAD-like helicases superfamily; Region: DEXDc; smart00487 696749003417 ATP binding site [chemical binding]; other site 696749003418 Mg++ binding site [ion binding]; other site 696749003419 motif III; other site 696749003420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749003421 nucleotide binding region [chemical binding]; other site 696749003422 ATP-binding site [chemical binding]; other site 696749003423 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 696749003424 putative FMN binding site [chemical binding]; other site 696749003425 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 696749003426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003427 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 696749003428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696749003429 catalytic core [active] 696749003430 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 696749003431 GspL periplasmic domain; Region: GspL_C; cl14909 696749003432 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 696749003433 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 696749003434 quinone interaction residues [chemical binding]; other site 696749003435 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 696749003436 active site 696749003437 catalytic residues [active] 696749003438 FMN binding site [chemical binding]; other site 696749003439 substrate binding site [chemical binding]; other site 696749003440 Colicin V production protein; Region: Colicin_V; cl00567 696749003441 amidophosphoribosyltransferase; Provisional; Region: PRK09246 696749003442 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 696749003443 active site 696749003444 tetramer interface [polypeptide binding]; other site 696749003445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749003446 active site 696749003447 Peptidase family M48; Region: Peptidase_M48; cl12018 696749003448 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 696749003449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003450 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 696749003451 Peptidase family M48; Region: Peptidase_M48; cl12018 696749003452 GatB domain; Region: GatB_Yqey; cl11497 696749003453 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 696749003454 UGMP family protein; Validated; Region: PRK09604 696749003455 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 696749003456 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 696749003457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749003458 Walker A motif; other site 696749003459 ATP binding site [chemical binding]; other site 696749003460 Walker B motif; other site 696749003461 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 696749003462 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 696749003463 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 696749003464 active site 696749003465 nucleophile elbow; other site 696749003466 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749003467 substrate binding site [chemical binding]; other site 696749003468 activation loop (A-loop); other site 696749003469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749003470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749003471 Helix-turn-helix domains; Region: HTH; cl00088 696749003472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749003473 dimerization interface [polypeptide binding]; other site 696749003474 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 696749003475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749003476 inhibitor-cofactor binding pocket; inhibition site 696749003477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749003478 catalytic residue [active] 696749003479 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 696749003480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749003481 tetrameric interface [polypeptide binding]; other site 696749003482 NAD binding site [chemical binding]; other site 696749003483 catalytic residues [active] 696749003484 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 696749003485 Spore germination protein; Region: Spore_permease; cl15802 696749003486 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 696749003487 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749003488 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749003489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749003490 active site 696749003491 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 696749003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749003493 S-adenosylmethionine binding site [chemical binding]; other site 696749003494 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 696749003495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 696749003496 active site 696749003497 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 696749003498 Sensors of blue-light using FAD; Region: BLUF; cl04855 696749003499 LysE type translocator; Region: LysE; cl00565 696749003500 Cupin domain; Region: Cupin_2; cl09118 696749003501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003502 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749003503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003504 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 696749003505 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 696749003506 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 696749003507 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 696749003508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749003509 Walker A motif; other site 696749003510 ATP binding site [chemical binding]; other site 696749003511 Walker B motif; other site 696749003512 Transcriptional regulators [Transcription]; Region: FadR; COG2186 696749003513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749003514 DNA-binding site [nucleotide binding]; DNA binding site 696749003515 FCD domain; Region: FCD; cl11656 696749003516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749003517 Helix-turn-helix domains; Region: HTH; cl00088 696749003518 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749003519 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749003520 Spore Coat Protein U domain; Region: SCPU; cl02253 696749003521 Spore Coat Protein U domain; Region: SCPU; cl02253 696749003522 Spore Coat Protein U domain; Region: SCPU; cl02253 696749003523 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 696749003524 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 696749003525 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749003526 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 696749003527 PapC C-terminal domain; Region: PapC_C; pfam13953 696749003528 Spore Coat Protein U domain; Region: SCPU; cl02253 696749003529 Spore Coat Protein U domain; Region: SCPU; cl02253 696749003530 proline/glycine betaine transporter; Provisional; Region: PRK10642 696749003531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749003532 putative substrate translocation pore; other site 696749003533 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 696749003534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749003535 Helix-turn-helix domains; Region: HTH; cl00088 696749003536 EamA-like transporter family; Region: EamA; cl01037 696749003537 EamA-like transporter family; Region: EamA; cl01037 696749003538 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 696749003539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749003540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749003541 homodimer interface [polypeptide binding]; other site 696749003542 catalytic residue [active] 696749003543 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 696749003544 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 696749003545 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 696749003546 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 696749003547 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 696749003548 Paraquat-inducible protein A; Region: PqiA; pfam04403 696749003549 Paraquat-inducible protein A; Region: PqiA; pfam04403 696749003550 mce related protein; Region: MCE; pfam02470 696749003551 mce related protein; Region: MCE; pfam02470 696749003552 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 696749003553 mce related protein; Region: MCE; pfam02470 696749003554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 696749003555 Protein of unknown function (DUF330); Region: DUF330; cl01135 696749003556 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 696749003557 aromatic amino acid exporter; Provisional; Region: PRK11689 696749003558 EamA-like transporter family; Region: EamA; cl01037 696749003559 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 696749003560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 696749003561 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 696749003563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749003564 Helix-turn-helix domains; Region: HTH; cl00088 696749003565 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749003566 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749003567 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 696749003568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749003569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003570 dimer interface [polypeptide binding]; other site 696749003571 conserved gate region; other site 696749003572 ABC-ATPase subunit interface; other site 696749003573 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 696749003574 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 696749003575 Walker A/P-loop; other site 696749003576 ATP binding site [chemical binding]; other site 696749003577 Q-loop/lid; other site 696749003578 ABC transporter signature motif; other site 696749003579 Walker B; other site 696749003580 D-loop; other site 696749003581 H-loop/switch region; other site 696749003582 NIL domain; Region: NIL; cl09633 696749003583 NMT1-like family; Region: NMT1_2; cl15260 696749003584 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 696749003585 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 696749003586 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749003587 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 696749003588 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 696749003589 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 696749003590 purine monophosphate binding site [chemical binding]; other site 696749003591 dimer interface [polypeptide binding]; other site 696749003592 putative catalytic residues [active] 696749003593 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 696749003594 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 696749003595 Helix-turn-helix domains; Region: HTH; cl00088 696749003596 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 696749003597 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 696749003598 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 696749003599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749003600 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 696749003601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003602 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 696749003603 Predicted transcriptional regulator [Transcription]; Region: COG2378 696749003604 WYL domain; Region: WYL; cl14852 696749003605 Uncharacterized conserved protein [Function unknown]; Region: COG2308 696749003606 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 696749003607 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 696749003608 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 696749003609 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 696749003610 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 696749003611 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 696749003612 alanine racemase; Reviewed; Region: alr; PRK00053 696749003613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 696749003614 active site 696749003615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696749003616 substrate binding site [chemical binding]; other site 696749003617 catalytic residues [active] 696749003618 dimer interface [polypeptide binding]; other site 696749003619 replicative DNA helicase; Region: DnaB; TIGR00665 696749003620 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 696749003621 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 696749003622 Walker A motif; other site 696749003623 ATP binding site [chemical binding]; other site 696749003624 Walker B motif; other site 696749003625 DNA binding loops [nucleotide binding] 696749003626 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 696749003627 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 696749003628 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 696749003629 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 696749003630 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 696749003631 UbiA prenyltransferase family; Region: UbiA; cl00337 696749003632 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 696749003633 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 696749003634 Subunit I/III interface [polypeptide binding]; other site 696749003635 Subunit III/IV interface [polypeptide binding]; other site 696749003636 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 696749003637 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 696749003638 D-pathway; other site 696749003639 Putative ubiquinol binding site [chemical binding]; other site 696749003640 Low-spin heme (heme b) binding site [chemical binding]; other site 696749003641 Putative water exit pathway; other site 696749003642 Binuclear center (heme o3/CuB) [ion binding]; other site 696749003643 K-pathway; other site 696749003644 Putative proton exit pathway; other site 696749003645 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 696749003646 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 696749003647 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 696749003648 RDD family; Region: RDD; cl00746 696749003649 phosphoenolpyruvate synthase; Validated; Region: PRK06464 696749003650 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 696749003651 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 696749003652 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 696749003653 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 696749003654 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 696749003655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696749003656 binding surface 696749003657 TPR motif; other site 696749003658 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 696749003659 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 696749003660 putative active site [active] 696749003661 putative metal binding site [ion binding]; other site 696749003662 N-glycosyltransferase; Provisional; Region: PRK11204 696749003663 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 696749003664 DXD motif; other site 696749003665 PgaD-like protein; Region: PgaD; cl14676 696749003666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749003667 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 696749003668 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 696749003669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749003670 Helix-turn-helix domains; Region: HTH; cl00088 696749003671 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749003672 putative effector binding pocket; other site 696749003673 dimerization interface [polypeptide binding]; other site 696749003674 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 696749003675 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 696749003676 potential catalytic triad [active] 696749003677 conserved cys residue [active] 696749003678 peptide chain release factor 1; Validated; Region: prfA; PRK00591 696749003679 RF-1 domain; Region: RF-1; cl02875 696749003680 RF-1 domain; Region: RF-1; cl02875 696749003681 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 696749003682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749003683 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 696749003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749003685 ABC-ATPase subunit interface; other site 696749003686 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749003687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749003688 substrate binding pocket [chemical binding]; other site 696749003689 membrane-bound complex binding site; other site 696749003690 hinge residues; other site 696749003691 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749003692 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696749003693 SurA N-terminal domain; Region: SurA_N_3; cl07813 696749003694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003695 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749003696 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 696749003697 NAD binding site [chemical binding]; other site 696749003698 homodimer interface [polypeptide binding]; other site 696749003699 homotetramer interface [polypeptide binding]; other site 696749003700 active site 696749003701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749003702 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749003703 active site 696749003704 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 696749003705 AMP-binding enzyme; Region: AMP-binding; cl15778 696749003706 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749003707 Flavin Reductases; Region: FlaRed; cl00801 696749003708 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 696749003709 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 696749003710 ATP binding site [chemical binding]; other site 696749003711 substrate interface [chemical binding]; other site 696749003712 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749003713 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 696749003714 homooctamer interface [polypeptide binding]; other site 696749003715 active site 696749003716 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 696749003717 catalytic center binding site [active] 696749003718 ATP binding site [chemical binding]; other site 696749003719 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 696749003720 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 696749003721 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 696749003722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 696749003723 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749003724 K+-transporting ATPase, c chain; Region: KdpC; cl00944 696749003725 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 696749003726 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 696749003727 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 696749003728 Ligand Binding Site [chemical binding]; other site 696749003729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749003730 dimer interface [polypeptide binding]; other site 696749003731 phosphorylation site [posttranslational modification] 696749003732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749003733 ATP binding site [chemical binding]; other site 696749003734 Mg2+ binding site [ion binding]; other site 696749003735 G-X-G motif; other site 696749003736 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 696749003737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749003738 active site 696749003739 phosphorylation site [posttranslational modification] 696749003740 intermolecular recognition site; other site 696749003741 dimerization interface [polypeptide binding]; other site 696749003742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749003743 DNA binding site [nucleotide binding] 696749003744 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 696749003745 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 696749003746 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 696749003747 Mor transcription activator family; Region: Mor; cl02360 696749003748 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 696749003749 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 696749003750 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696749003751 IHF dimer interface [polypeptide binding]; other site 696749003752 IHF - DNA interface [nucleotide binding]; other site 696749003753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749003754 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 696749003755 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 696749003756 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 696749003757 Integrase core domain; Region: rve; cl01316 696749003758 Helix-turn-helix domains; Region: HTH; cl00088 696749003759 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 696749003760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 696749003761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749003762 non-specific DNA binding site [nucleotide binding]; other site 696749003763 salt bridge; other site 696749003764 Predicted transcriptional regulator [Transcription]; Region: COG2932 696749003765 sequence-specific DNA binding site [nucleotide binding]; other site 696749003766 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749003767 Catalytic site [active] 696749003768 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 696749003769 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 696749003770 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 696749003771 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 696749003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749003773 Protein of unknown function (DUF935); Region: DUF935; pfam06074 696749003774 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 696749003775 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 696749003776 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 696749003777 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 696749003778 Mu-like prophage I protein [General function prediction only]; Region: COG4388 696749003779 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 696749003780 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 696749003781 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 696749003782 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 696749003783 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 696749003784 Domain of unknown function (DUF1834); Region: DUF1834; cl02087 696749003785 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 696749003786 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 696749003787 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 696749003788 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 696749003789 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 696749003790 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 696749003791 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 696749003792 Phage protein GP46; Region: GP46; cl01814 696749003793 Baseplate J-like protein; Region: Baseplate_J; cl01294 696749003794 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 696749003795 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 696749003796 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 696749003797 diiron binding motif [ion binding]; other site 696749003798 lysophospholipid transporter LplT; Provisional; Region: PRK11195 696749003799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749003800 putative substrate translocation pore; other site 696749003801 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 696749003802 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749003803 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 696749003804 Surface antigen; Region: Bac_surface_Ag; cl03097 696749003805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 696749003806 Family of unknown function (DUF490); Region: DUF490; pfam04357 696749003807 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 696749003808 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 696749003809 substrate binding site [chemical binding]; other site 696749003810 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 696749003811 substrate binding site [chemical binding]; other site 696749003812 ligand binding site [chemical binding]; other site 696749003813 Ion transport protein; Region: Ion_trans; pfam00520 696749003814 Ion channel; Region: Ion_trans_2; cl11596 696749003815 CCC1-related family of proteins; Region: CCC1_like; cl00278 696749003816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749003817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749003818 putative substrate translocation pore; other site 696749003819 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 696749003820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749003821 Helix-turn-helix domains; Region: HTH; cl00088 696749003822 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 696749003823 putative dimerization interface [polypeptide binding]; other site 696749003824 Protein of unknown function (DUF441); Region: DUF441; cl01041 696749003825 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 696749003826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 696749003827 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 696749003828 active site 696749003829 uracil binding [chemical binding]; other site 696749003830 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 696749003831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749003832 Coenzyme A binding pocket [chemical binding]; other site 696749003833 RelB antitoxin; Region: RelB; cl01171 696749003834 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 696749003835 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 696749003836 probable active site [active] 696749003837 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 696749003838 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 696749003839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749003840 ATP binding site [chemical binding]; other site 696749003841 Mg2+ binding site [ion binding]; other site 696749003842 G-X-G motif; other site 696749003843 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 696749003844 ATP binding site [chemical binding]; other site 696749003845 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 696749003846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749003847 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 696749003848 Sm1 motif; other site 696749003849 intra - hexamer interaction site; other site 696749003850 inter - hexamer interaction site [polypeptide binding]; other site 696749003851 nucleotide binding pocket [chemical binding]; other site 696749003852 Sm2 motif; other site 696749003853 EamA-like transporter family; Region: EamA; cl01037 696749003854 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 696749003855 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 696749003856 dimer interface [polypeptide binding]; other site 696749003857 FMN binding site [chemical binding]; other site 696749003858 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 696749003859 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696749003860 putative active site [active] 696749003861 putative metal binding site [ion binding]; other site 696749003862 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 696749003863 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 696749003864 substrate binding site [chemical binding]; other site 696749003865 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 696749003866 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749003867 active site 696749003868 HIGH motif; other site 696749003869 nucleotide binding site [chemical binding]; other site 696749003870 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 696749003871 KMSKS motif; other site 696749003872 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 696749003873 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 696749003874 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 696749003875 catalytic triad [active] 696749003876 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 696749003877 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 696749003878 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 696749003879 ethanolamine permease; Region: 2A0305; TIGR00908 696749003880 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 696749003881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749003882 NAD(P) binding site [chemical binding]; other site 696749003883 catalytic residues [active] 696749003884 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 696749003885 Helix-turn-helix domains; Region: HTH; cl00088 696749003886 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 696749003887 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749003888 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 696749003889 putative alcohol dehydrogenase; Provisional; Region: PRK09860 696749003890 dimer interface [polypeptide binding]; other site 696749003891 active site 696749003892 metal binding site [ion binding]; metal-binding site 696749003893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749003894 PIF1-like helicase; Region: PIF1; pfam05970 696749003895 Walker A motif; other site 696749003896 ATP binding site [chemical binding]; other site 696749003897 Walker B motif; other site 696749003898 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 696749003899 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 696749003900 putative substrate binding pocket [chemical binding]; other site 696749003901 trimer interface [polypeptide binding]; other site 696749003902 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696749003903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749003904 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 696749003905 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 696749003906 substrate binding site [chemical binding]; other site 696749003907 multimerization interface [polypeptide binding]; other site 696749003908 ATP binding site [chemical binding]; other site 696749003909 aminopeptidase N; Provisional; Region: pepN; PRK14015 696749003910 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 696749003911 active site 696749003912 Zn binding site [ion binding]; other site 696749003913 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696749003914 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 696749003915 C-terminal domain interface [polypeptide binding]; other site 696749003916 GSH binding site (G-site) [chemical binding]; other site 696749003917 dimer interface [polypeptide binding]; other site 696749003918 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 696749003919 N-terminal domain interface [polypeptide binding]; other site 696749003920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003921 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 696749003922 NAD(P) binding site [chemical binding]; other site 696749003923 active site 696749003924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003925 active site 696749003926 Chorismate mutase type II; Region: CM_2; cl00693 696749003927 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 696749003928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749003929 putative DNA binding site [nucleotide binding]; other site 696749003930 putative Zn2+ binding site [ion binding]; other site 696749003931 AsnC family; Region: AsnC_trans_reg; pfam01037 696749003932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749003933 Helix-turn-helix domains; Region: HTH; cl00088 696749003934 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749003935 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749003936 N-terminal plug; other site 696749003937 ligand-binding site [chemical binding]; other site 696749003938 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 696749003939 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696749003940 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 696749003941 Predicted acetyltransferase [General function prediction only]; Region: COG3153 696749003942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749003943 Coenzyme A binding pocket [chemical binding]; other site 696749003944 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 696749003945 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749003946 N-terminal plug; other site 696749003947 ligand-binding site [chemical binding]; other site 696749003948 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749003949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749003950 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 696749003951 Walker A/P-loop; other site 696749003952 ATP binding site [chemical binding]; other site 696749003953 Q-loop/lid; other site 696749003954 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749003955 ABC transporter signature motif; other site 696749003956 Walker B; other site 696749003957 D-loop; other site 696749003958 ABC transporter; Region: ABC_tran_2; pfam12848 696749003959 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749003960 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749003961 Ligand Binding Site [chemical binding]; other site 696749003962 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 696749003963 RDD family; Region: RDD; cl00746 696749003964 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 696749003965 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 696749003966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 696749003967 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 696749003968 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 696749003969 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 696749003970 MgtC family; Region: MgtC; pfam02308 696749003971 Benzoate membrane transport protein; Region: BenE; pfam03594 696749003972 benzoate transporter; Region: benE; TIGR00843 696749003973 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 696749003974 Helix-turn-helix domains; Region: HTH; cl00088 696749003975 AsnC family; Region: AsnC_trans_reg; pfam01037 696749003976 LysE type translocator; Region: LysE; cl00565 696749003977 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 696749003978 transaldolase-like protein; Provisional; Region: PTZ00411 696749003979 active site 696749003980 dimer interface [polypeptide binding]; other site 696749003981 catalytic residue [active] 696749003982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749003983 Helix-turn-helix domains; Region: HTH; cl00088 696749003984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749003985 dimerization interface [polypeptide binding]; other site 696749003986 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696749003987 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696749003988 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 696749003989 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749003990 dimer interface [polypeptide binding]; other site 696749003991 active site 696749003992 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 696749003993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749003994 NAD(P) binding site [chemical binding]; other site 696749003995 active site 696749003996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 696749003997 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 696749003998 active site 2 [active] 696749003999 active site 1 [active] 696749004000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749004001 TetR family transcriptional regulator; Provisional; Region: PRK14996 696749004002 Helix-turn-helix domains; Region: HTH; cl00088 696749004003 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 696749004004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004005 putative substrate translocation pore; other site 696749004006 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 696749004007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749004008 Walker A motif; other site 696749004009 ATP binding site [chemical binding]; other site 696749004010 Walker B motif; other site 696749004011 arginine finger; other site 696749004012 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 696749004013 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 696749004014 Phosphoesterase family; Region: Phosphoesterase; cl15450 696749004015 Domain of unknown function (DUF756); Region: DUF756; pfam05506 696749004016 Domain of unknown function (DUF756); Region: DUF756; pfam05506 696749004017 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696749004018 active site 696749004019 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 696749004020 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 696749004021 putative active site [active] 696749004022 metal binding site [ion binding]; metal-binding site 696749004023 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 696749004024 Low molecular weight phosphatase family; Region: LMWPc; cd00115 696749004025 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 696749004026 active site 696749004027 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 696749004028 FAD binding domain; Region: FAD_binding_4; pfam01565 696749004029 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 696749004030 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 696749004031 putative active site [active] 696749004032 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 696749004033 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749004034 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 696749004035 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 696749004036 active site 696749004037 FMN binding site [chemical binding]; other site 696749004038 substrate binding site [chemical binding]; other site 696749004039 3Fe-4S cluster binding site [ion binding]; other site 696749004040 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 696749004041 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749004042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749004043 Helix-turn-helix domains; Region: HTH; cl00088 696749004044 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004045 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004046 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749004047 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 696749004048 active site 696749004049 Int/Topo IB signature motif; other site 696749004050 DNA binding site [nucleotide binding] 696749004051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749004052 non-specific DNA binding site [nucleotide binding]; other site 696749004053 salt bridge; other site 696749004054 sequence-specific DNA binding site [nucleotide binding]; other site 696749004055 Domain of unknown function (DUF955); Region: DUF955; cl01076 696749004056 AAA domain; Region: AAA_24; pfam13479 696749004057 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 696749004058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749004059 Predicted transcriptional regulator [Transcription]; Region: COG2932 696749004060 sequence-specific DNA binding site [nucleotide binding]; other site 696749004061 salt bridge; other site 696749004062 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749004063 Catalytic site [active] 696749004064 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 696749004065 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 696749004066 putative active site [active] 696749004067 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 696749004068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 696749004069 Terminase-like family; Region: Terminase_6; pfam03237 696749004070 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 696749004071 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 696749004072 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 696749004073 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 696749004074 Putative stress-responsive nuclear envelope protein; Region: Ish1; pfam10281 696749004075 Bacterial SH3 domain; Region: SH3_3; cl02551 696749004076 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 696749004077 YcfA-like protein; Region: YcfA; cl00752 696749004078 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 696749004079 Arc-like DNA binding domain; Region: Arc; pfam03869 696749004080 Mnt; Region: mnt; PHA01513 696749004081 KilA-N domain; Region: KilA-N; pfam04383 696749004082 tape measure domain; Region: tape_meas_nterm; TIGR02675 696749004083 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 696749004084 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 696749004085 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 696749004086 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 696749004087 integrase; Provisional; Region: PRK09692 696749004088 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 696749004089 active site 696749004090 Int/Topo IB signature motif; other site 696749004091 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 696749004092 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 696749004093 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 696749004094 active site 696749004095 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 696749004096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 696749004097 glutamine synthetase; Provisional; Region: glnA; PRK09469 696749004098 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 696749004099 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 696749004100 UTRA domain; Region: UTRA; cl01230 696749004101 UbiA prenyltransferase family; Region: UbiA; cl00337 696749004102 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 696749004103 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 696749004104 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 696749004105 putative active site [active] 696749004106 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 696749004107 superoxide dismutase; Provisional; Region: PRK10543 696749004108 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 696749004109 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 696749004110 Uncharacterized conserved protein [Function unknown]; Region: COG0327 696749004111 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 696749004112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696749004113 protein binding site [polypeptide binding]; other site 696749004114 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 696749004115 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 696749004116 active site 696749004117 NTP binding site [chemical binding]; other site 696749004118 metal binding triad [ion binding]; metal-binding site 696749004119 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 696749004120 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 696749004121 Malic enzyme, N-terminal domain; Region: malic; pfam00390 696749004122 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 696749004123 putative NAD(P) binding site [chemical binding]; other site 696749004124 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 696749004125 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 696749004126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 696749004127 PAS domain; Region: PAS_9; pfam13426 696749004128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749004129 metal binding site [ion binding]; metal-binding site 696749004130 active site 696749004131 I-site; other site 696749004132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 696749004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 696749004134 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 696749004135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 696749004136 Integrase core domain; Region: rve; cl01316 696749004137 Integrase core domain; Region: rve; cl01316 696749004138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749004139 Coenzyme A binding pocket [chemical binding]; other site 696749004140 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749004141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 696749004142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 696749004143 Integrase core domain; Region: rve; cl01316 696749004144 Integrase core domain; Region: rve; cl01316 696749004145 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749004146 classical (c) SDRs; Region: SDR_c; cd05233 696749004147 short chain dehydrogenase; Provisional; Region: PRK05650 696749004148 NAD(P) binding site [chemical binding]; other site 696749004149 active site 696749004150 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749004151 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749004152 Helix-turn-helix domains; Region: HTH; cl00088 696749004153 Pirin-related protein [General function prediction only]; Region: COG1741 696749004154 Cupin domain; Region: Cupin_2; cl09118 696749004155 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749004156 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749004157 classical (c) SDRs; Region: SDR_c; cd05233 696749004158 short chain dehydrogenase; Provisional; Region: PRK05650 696749004159 NAD(P) binding site [chemical binding]; other site 696749004160 active site 696749004161 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749004162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004163 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004165 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 696749004166 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 696749004167 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 696749004168 active site 696749004169 purine riboside binding site [chemical binding]; other site 696749004170 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 696749004171 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 696749004172 RNA/DNA hybrid binding site [nucleotide binding]; other site 696749004173 active site 696749004174 Global regulator protein family; Region: CsrA; cl00670 696749004175 aspartate kinase; Reviewed; Region: PRK06635 696749004176 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 696749004177 putative nucleotide binding site [chemical binding]; other site 696749004178 putative catalytic residues [active] 696749004179 putative Mg ion binding site [ion binding]; other site 696749004180 putative aspartate binding site [chemical binding]; other site 696749004181 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 696749004182 putative allosteric regulatory site; other site 696749004183 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 696749004184 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 696749004185 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 696749004186 motif 1; other site 696749004187 active site 696749004188 motif 2; other site 696749004189 motif 3; other site 696749004190 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 696749004191 DHHA1 domain; Region: DHHA1; pfam02272 696749004192 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 696749004193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004194 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 696749004195 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 696749004196 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 696749004197 dimer interface [polypeptide binding]; other site 696749004198 motif 1; other site 696749004199 active site 696749004200 motif 2; other site 696749004201 motif 3; other site 696749004202 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 696749004203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749004204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749004205 Peptidase family M48; Region: Peptidase_M48; cl12018 696749004206 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 696749004207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 696749004208 active site 696749004209 catalytic tetrad [active] 696749004210 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 696749004211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 696749004212 ligand binding site [chemical binding]; other site 696749004213 flexible hinge region; other site 696749004214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 696749004215 putative switch regulator; other site 696749004216 non-specific DNA interactions [nucleotide binding]; other site 696749004217 DNA binding site [nucleotide binding] 696749004218 sequence specific DNA binding site [nucleotide binding]; other site 696749004219 putative cAMP binding site [chemical binding]; other site 696749004220 OsmC-like protein; Region: OsmC; cl00767 696749004221 Predicted acetyltransferase [General function prediction only]; Region: COG3153 696749004222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749004223 Coenzyme A binding pocket [chemical binding]; other site 696749004224 Peptidase family M23; Region: Peptidase_M23; pfam01551 696749004225 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 696749004226 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 696749004227 Clp amino terminal domain; Region: Clp_N; pfam02861 696749004228 Clp amino terminal domain; Region: Clp_N; pfam02861 696749004229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749004230 Walker A motif; other site 696749004231 ATP binding site [chemical binding]; other site 696749004232 Walker B motif; other site 696749004233 arginine finger; other site 696749004234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749004235 Walker A motif; other site 696749004236 ATP binding site [chemical binding]; other site 696749004237 Walker B motif; other site 696749004238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 696749004239 Competence-damaged protein; Region: CinA; cl00666 696749004240 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 696749004241 THUMP domain; Region: THUMP; cl12076 696749004242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749004244 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 696749004245 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 696749004246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004247 dihydroorotase; Validated; Region: pyrC; PRK09357 696749004248 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 696749004249 active site 696749004250 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749004251 ligand binding site [chemical binding]; other site 696749004252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004253 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 696749004254 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696749004255 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 696749004256 putative C-terminal domain interface [polypeptide binding]; other site 696749004257 putative GSH binding site (G-site) [chemical binding]; other site 696749004258 putative dimer interface [polypeptide binding]; other site 696749004259 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 696749004260 putative N-terminal domain interface [polypeptide binding]; other site 696749004261 putative dimer interface [polypeptide binding]; other site 696749004262 putative substrate binding pocket (H-site) [chemical binding]; other site 696749004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749004264 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 696749004265 Lamin Tail Domain; Region: LTD; pfam00932 696749004266 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 696749004267 generic binding surface II; other site 696749004268 generic binding surface I; other site 696749004269 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 696749004270 putative active site [active] 696749004271 putative catalytic site [active] 696749004272 putative Mg binding site IVb [ion binding]; other site 696749004273 putative phosphate binding site [ion binding]; other site 696749004274 putative DNA binding site [nucleotide binding]; other site 696749004275 putative Mg binding site IVa [ion binding]; other site 696749004276 glutathionine S-transferase; Provisional; Region: PRK10542 696749004277 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 696749004278 C-terminal domain interface [polypeptide binding]; other site 696749004279 GSH binding site (G-site) [chemical binding]; other site 696749004280 dimer interface [polypeptide binding]; other site 696749004281 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 696749004282 dimer interface [polypeptide binding]; other site 696749004283 N-terminal domain interface [polypeptide binding]; other site 696749004284 substrate binding pocket (H-site) [chemical binding]; other site 696749004285 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 696749004286 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 696749004287 catalytic residue [active] 696749004288 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 696749004289 catalytic residues [active] 696749004290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749004291 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 696749004292 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 696749004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749004294 S-adenosylmethionine binding site [chemical binding]; other site 696749004295 KTSC domain; Region: KTSC; pfam13619 696749004296 peroxiredoxin; Region: AhpC; TIGR03137 696749004297 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 696749004298 dimer interface [polypeptide binding]; other site 696749004299 decamer (pentamer of dimers) interface [polypeptide binding]; other site 696749004300 catalytic triad [active] 696749004301 peroxidatic and resolving cysteines [active] 696749004302 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 696749004303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749004304 ATP binding site [chemical binding]; other site 696749004305 putative Mg++ binding site [ion binding]; other site 696749004306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749004307 nucleotide binding region [chemical binding]; other site 696749004308 ATP-binding site [chemical binding]; other site 696749004309 Helicase associated domain (HA2); Region: HA2; cl04503 696749004310 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 696749004311 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 696749004312 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 696749004313 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 696749004314 dimer interface [polypeptide binding]; other site 696749004315 active site 696749004316 CoA binding pocket [chemical binding]; other site 696749004317 outer membrane porin, OprD family; Region: OprD; pfam03573 696749004318 benzoate transport; Region: 2A0115; TIGR00895 696749004319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004320 putative substrate translocation pore; other site 696749004321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004322 putative substrate translocation pore; other site 696749004323 benzoate transporter; Region: benE; TIGR00843 696749004324 Benzoate membrane transport protein; Region: BenE; pfam03594 696749004325 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 696749004326 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 696749004327 putative NAD(P) binding site [chemical binding]; other site 696749004328 active site 696749004329 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 696749004330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749004331 catalytic loop [active] 696749004332 iron binding site [ion binding]; other site 696749004333 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 696749004334 FAD binding pocket [chemical binding]; other site 696749004335 FAD binding motif [chemical binding]; other site 696749004336 phosphate binding motif [ion binding]; other site 696749004337 beta-alpha-beta structure motif; other site 696749004338 NAD binding pocket [chemical binding]; other site 696749004339 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 696749004340 inter-subunit interface; other site 696749004341 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 696749004342 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 696749004343 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 696749004344 putative alpha subunit interface [polypeptide binding]; other site 696749004345 putative active site [active] 696749004346 putative substrate binding site [chemical binding]; other site 696749004347 Fe binding site [ion binding]; other site 696749004348 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749004349 Helix-turn-helix domains; Region: HTH; cl00088 696749004350 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 696749004351 dimerizarion interface [polypeptide binding]; other site 696749004352 CrgA pocket; other site 696749004353 substrate binding pocket [chemical binding]; other site 696749004354 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696749004355 metal-binding site [ion binding] 696749004356 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696749004357 metal-binding site [ion binding] 696749004358 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 696749004359 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696749004360 metal-binding site [ion binding] 696749004361 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 696749004362 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749004363 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 696749004364 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 696749004365 DNA binding residues [nucleotide binding] 696749004366 dimer interface [polypeptide binding]; other site 696749004367 copper binding site [ion binding]; other site 696749004368 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 696749004369 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 696749004370 dimerization interface [polypeptide binding]; other site 696749004371 LysE type translocator; Region: LysE; cl00565 696749004372 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 696749004373 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 696749004374 generic binding surface II; other site 696749004375 generic binding surface I; other site 696749004376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749004377 non-specific DNA binding site [nucleotide binding]; other site 696749004378 salt bridge; other site 696749004379 Predicted transcriptional regulator [Transcription]; Region: COG2932 696749004380 sequence-specific DNA binding site [nucleotide binding]; other site 696749004381 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749004382 Catalytic site [active] 696749004383 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 696749004384 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 696749004385 LysE type translocator; Region: LysE; cl00565 696749004386 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 696749004387 DNA-binding site [nucleotide binding]; DNA binding site 696749004388 RNA-binding motif; other site 696749004389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004390 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004391 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 696749004392 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 696749004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004394 putative substrate translocation pore; other site 696749004395 Helix-turn-helix domains; Region: HTH; cl00088 696749004396 Domain of unknown function (DUF305); Region: DUF305; cl15795 696749004397 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 696749004398 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 696749004399 active site 696749004400 HIGH motif; other site 696749004401 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 696749004402 KMSKS motif; other site 696749004403 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 696749004404 tRNA binding surface [nucleotide binding]; other site 696749004405 anticodon binding site; other site 696749004406 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 696749004407 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 696749004408 putative active site [active] 696749004409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 696749004410 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749004411 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 696749004412 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 696749004413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 696749004414 OstA-like protein; Region: OstA; cl00844 696749004415 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 696749004416 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 696749004417 Walker A/P-loop; other site 696749004418 ATP binding site [chemical binding]; other site 696749004419 Q-loop/lid; other site 696749004420 ABC transporter signature motif; other site 696749004421 Walker B; other site 696749004422 D-loop; other site 696749004423 H-loop/switch region; other site 696749004424 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 696749004425 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 696749004426 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 696749004427 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 696749004428 Walker A/P-loop; other site 696749004429 ATP binding site [chemical binding]; other site 696749004430 Q-loop/lid; other site 696749004431 ABC transporter signature motif; other site 696749004432 Walker B; other site 696749004433 D-loop; other site 696749004434 H-loop/switch region; other site 696749004435 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 696749004436 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749004437 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749004438 Uncharacterized conserved protein [Function unknown]; Region: COG1739 696749004439 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 696749004440 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 696749004441 putative trimer interface [polypeptide binding]; other site 696749004442 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 696749004443 trimer interface [polypeptide binding]; other site 696749004444 active site 696749004445 substrate binding site [chemical binding]; other site 696749004446 putative CoA binding site [chemical binding]; other site 696749004447 CoA binding site [chemical binding]; other site 696749004448 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749004449 Ligand Binding Site [chemical binding]; other site 696749004450 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 696749004451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 696749004453 4Fe-4S binding domain; Region: Fer4; cl02805 696749004454 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 696749004455 Predicted acetyltransferase [General function prediction only]; Region: COG3153 696749004456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749004457 Coenzyme A binding pocket [chemical binding]; other site 696749004458 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 696749004459 MutS domain I; Region: MutS_I; pfam01624 696749004460 MutS domain II; Region: MutS_II; pfam05188 696749004461 MutS family domain IV; Region: MutS_IV; pfam05190 696749004462 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 696749004463 Walker A/P-loop; other site 696749004464 ATP binding site [chemical binding]; other site 696749004465 Q-loop/lid; other site 696749004466 ABC transporter signature motif; other site 696749004467 Walker B; other site 696749004468 D-loop; other site 696749004469 H-loop/switch region; other site 696749004470 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 696749004471 Helix-turn-helix domains; Region: HTH; cl00088 696749004472 AsnC family; Region: AsnC_trans_reg; pfam01037 696749004473 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 696749004474 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 696749004475 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 696749004476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696749004477 putative acyl-acceptor binding pocket; other site 696749004478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749004479 Helix-turn-helix domains; Region: HTH; cl00088 696749004480 benzoate transport; Region: 2A0115; TIGR00895 696749004481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004482 putative substrate translocation pore; other site 696749004483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004484 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 696749004485 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 696749004486 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 696749004487 DNA binding residues [nucleotide binding] 696749004488 putative dimer interface [polypeptide binding]; other site 696749004489 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 696749004490 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 696749004491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004492 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749004493 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749004494 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 696749004495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749004496 motif II; other site 696749004497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749004498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 696749004499 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 696749004500 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 696749004501 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 696749004502 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 696749004503 RHS Repeat; Region: RHS_repeat; cl11982 696749004504 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 696749004505 RHS Repeat; Region: RHS_repeat; cl11982 696749004506 RHS Repeat; Region: RHS_repeat; cl11982 696749004507 RHS Repeat; Region: RHS_repeat; cl11982 696749004508 RHS Repeat; Region: RHS_repeat; cl11982 696749004509 RHS Repeat; Region: RHS_repeat; cl11982 696749004510 RHS protein; Region: RHS; pfam03527 696749004511 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 696749004512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749004513 Helix-turn-helix domains; Region: HTH; cl00088 696749004514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749004515 dimerization interface [polypeptide binding]; other site 696749004516 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 696749004517 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 696749004518 putative active site [active] 696749004519 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 696749004520 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 696749004521 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 696749004522 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 696749004523 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 696749004524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749004525 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749004526 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 696749004527 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696749004528 carboxyltransferase (CT) interaction site; other site 696749004529 biotinylation site [posttranslational modification]; other site 696749004530 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 696749004531 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 696749004532 putative Cl- selectivity filter; other site 696749004533 putative pore gating glutamate residue; other site 696749004534 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 696749004535 Sel1 repeat; Region: Sel1; cl02723 696749004536 Sel1 repeat; Region: Sel1; cl02723 696749004537 Sel1 repeat; Region: Sel1; cl02723 696749004538 Sel1 repeat; Region: Sel1; cl02723 696749004539 Sel1 repeat; Region: Sel1; cl02723 696749004540 Sel1 repeat; Region: Sel1; cl02723 696749004541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749004542 Helix-turn-helix domains; Region: HTH; cl00088 696749004543 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 696749004544 putative hydrophobic ligand binding site [chemical binding]; other site 696749004545 protein interface [polypeptide binding]; other site 696749004546 gate; other site 696749004547 potential frameshift: common BLAST hit: gi|184157600|ref|YP_001845939.1| threonine dehydrogenase 696749004548 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 696749004549 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 696749004550 NAD(P) binding site [chemical binding]; other site 696749004551 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 696749004552 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 696749004553 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 696749004554 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 696749004555 urea carboxylase; Region: urea_carbox; TIGR02712 696749004556 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749004557 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749004558 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 696749004559 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 696749004560 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 696749004561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696749004562 carboxyltransferase (CT) interaction site; other site 696749004563 biotinylation site [posttranslational modification]; other site 696749004564 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749004565 Helix-turn-helix domains; Region: HTH; cl00088 696749004566 nickel responsive regulator; Provisional; Region: PRK04460 696749004567 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 696749004568 allophanate hydrolase; Provisional; Region: PRK08186 696749004569 Amidase; Region: Amidase; cl11426 696749004570 NMT1-like family; Region: NMT1_2; cl15260 696749004571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 696749004572 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 696749004573 Walker A/P-loop; other site 696749004574 ATP binding site [chemical binding]; other site 696749004575 Q-loop/lid; other site 696749004576 ABC transporter signature motif; other site 696749004577 Walker B; other site 696749004578 D-loop; other site 696749004579 H-loop/switch region; other site 696749004580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749004581 dimer interface [polypeptide binding]; other site 696749004582 conserved gate region; other site 696749004583 putative PBP binding loops; other site 696749004584 ABC-ATPase subunit interface; other site 696749004585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 696749004586 Protein of unknown function (DUF770); Region: DUF770; cl01402 696749004587 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 696749004588 Protein of unknown function (DUF877); Region: DUF877; pfam05943 696749004589 Protein of unknown function (DUF796); Region: DUF796; cl01226 696749004590 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 696749004591 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 696749004592 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 696749004593 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 696749004594 FHIPEP family; Region: FHIPEP; pfam00771 696749004595 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 696749004596 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 696749004597 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004599 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 696749004600 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 696749004601 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 696749004602 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 696749004603 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 696749004604 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749004605 ligand binding site [chemical binding]; other site 696749004606 PAAR motif; Region: PAAR_motif; cl15808 696749004607 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 696749004608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749004609 Walker A motif; other site 696749004610 ATP binding site [chemical binding]; other site 696749004611 Walker B motif; other site 696749004612 arginine finger; other site 696749004613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749004614 Walker A motif; other site 696749004615 ATP binding site [chemical binding]; other site 696749004616 Walker B motif; other site 696749004617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 696749004618 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 696749004619 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 696749004620 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 696749004621 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 696749004622 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 696749004623 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 696749004624 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 696749004625 Helix-turn-helix domains; Region: HTH; cl00088 696749004626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749004627 dimerization interface [polypeptide binding]; other site 696749004628 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 696749004629 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 696749004630 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 696749004631 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 696749004632 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 696749004633 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 696749004634 nucleoside/Zn binding site; other site 696749004635 dimer interface [polypeptide binding]; other site 696749004636 catalytic motif [active] 696749004637 putative cyanate transporter; Provisional; Region: cynX; PRK09705 696749004638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004639 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 696749004640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749004641 Coenzyme A binding pocket [chemical binding]; other site 696749004642 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 696749004643 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004645 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 696749004646 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 696749004647 DNA binding residues [nucleotide binding] 696749004648 dimer interface [polypeptide binding]; other site 696749004649 [2Fe-2S] cluster binding site [ion binding]; other site 696749004650 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 696749004651 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 696749004652 Domain of unknown function (DUF333); Region: DUF333; pfam03891 696749004653 Potato inhibitor I family; Region: potato_inhibit; cl15459 696749004654 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 696749004655 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 696749004656 active site 696749004657 inhibitor site; inhibition site 696749004658 dimer interface [polypeptide binding]; other site 696749004659 catalytic residue [active] 696749004660 EamA-like transporter family; Region: EamA; cl01037 696749004661 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749004662 Transcriptional regulators [Transcription]; Region: GntR; COG1802 696749004663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749004664 DNA-binding site [nucleotide binding]; DNA binding site 696749004665 FCD domain; Region: FCD; cl11656 696749004666 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 696749004667 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 696749004668 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 696749004669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004670 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 696749004671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 696749004672 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 696749004673 PAS fold; Region: PAS_4; pfam08448 696749004674 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696749004675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749004676 metabolite-proton symporter; Region: 2A0106; TIGR00883 696749004677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004678 putative substrate translocation pore; other site 696749004679 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 696749004680 dimer interface [polypeptide binding]; other site 696749004681 NADP binding site [chemical binding]; other site 696749004682 catalytic residues [active] 696749004683 amino acid transporter; Region: 2A0306; TIGR00909 696749004684 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 696749004685 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 696749004686 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 696749004687 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 696749004688 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 696749004689 substrate binding site [chemical binding]; other site 696749004690 dimer interface [polypeptide binding]; other site 696749004691 NADP binding site [chemical binding]; other site 696749004692 catalytic residues [active] 696749004693 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 696749004694 substrate binding site [chemical binding]; other site 696749004695 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 696749004696 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 696749004697 Phenylacetic acid degradation B; Region: PaaB; cl01371 696749004698 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 696749004699 Domain of unknown function DUF59; Region: DUF59; cl00941 696749004700 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 696749004701 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 696749004702 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 696749004703 FAD binding pocket [chemical binding]; other site 696749004704 FAD binding motif [chemical binding]; other site 696749004705 phosphate binding motif [ion binding]; other site 696749004706 beta-alpha-beta structure motif; other site 696749004707 NAD(p) ribose binding residues [chemical binding]; other site 696749004708 NAD binding pocket [chemical binding]; other site 696749004709 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 696749004710 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749004711 catalytic loop [active] 696749004712 iron binding site [ion binding]; other site 696749004713 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 696749004714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749004715 substrate binding site [chemical binding]; other site 696749004716 oxyanion hole (OAH) forming residues; other site 696749004717 trimer interface [polypeptide binding]; other site 696749004718 enoyl-CoA hydratase; Provisional; Region: PRK08140 696749004719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749004720 substrate binding site [chemical binding]; other site 696749004721 oxyanion hole (OAH) forming residues; other site 696749004722 trimer interface [polypeptide binding]; other site 696749004723 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 696749004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749004726 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749004727 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 696749004728 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749004729 dimer interface [polypeptide binding]; other site 696749004730 active site 696749004731 AMP-binding enzyme; Region: AMP-binding; cl15778 696749004732 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 696749004733 PaaX-like protein; Region: PaaX; pfam07848 696749004734 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 696749004735 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 696749004736 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 696749004737 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 696749004738 putative trimer interface [polypeptide binding]; other site 696749004739 putative metal binding site [ion binding]; other site 696749004740 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749004741 CoenzymeA binding site [chemical binding]; other site 696749004742 subunit interaction site [polypeptide binding]; other site 696749004743 PHB binding site; other site 696749004744 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 696749004745 putative active site [active] 696749004746 putative NTP binding site [chemical binding]; other site 696749004747 putative nucleic acid binding site [nucleotide binding]; other site 696749004748 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004749 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749004751 Helix-turn-helix domains; Region: HTH; cl00088 696749004752 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 696749004753 putative heme binding pocket [chemical binding]; other site 696749004754 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 696749004755 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 696749004756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749004757 DNA-binding site [nucleotide binding]; DNA binding site 696749004758 FCD domain; Region: FCD; cl11656 696749004759 Amino acid synthesis; Region: AA_synth; pfam06684 696749004760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749004761 Flavin Reductases; Region: FlaRed; cl00801 696749004762 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 696749004763 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 696749004764 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749004765 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 696749004766 NAD(P) binding site [chemical binding]; other site 696749004767 catalytic residues [active] 696749004768 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749004769 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749004770 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749004771 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 696749004772 tetramerization interface [polypeptide binding]; other site 696749004773 NAD(P) binding site [chemical binding]; other site 696749004774 catalytic residues [active] 696749004775 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749004776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749004777 Helix-turn-helix domains; Region: HTH; cl00088 696749004778 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 696749004779 putative effector binding pocket; other site 696749004780 putative dimerization interface [polypeptide binding]; other site 696749004781 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749004782 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 696749004783 Helix-turn-helix domains; Region: HTH; cl00088 696749004784 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749004785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004786 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 696749004787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004788 transcriptional regulator protein; Region: phnR; TIGR03337 696749004789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749004790 DNA-binding site [nucleotide binding]; DNA binding site 696749004791 UTRA domain; Region: UTRA; cl01230 696749004792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749004793 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 696749004794 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 696749004795 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749004796 Walker A/P-loop; other site 696749004797 ATP binding site [chemical binding]; other site 696749004798 Q-loop/lid; other site 696749004799 ABC transporter signature motif; other site 696749004800 Walker B; other site 696749004801 D-loop; other site 696749004802 H-loop/switch region; other site 696749004803 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 696749004804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749004805 dimer interface [polypeptide binding]; other site 696749004806 conserved gate region; other site 696749004807 putative PBP binding loops; other site 696749004808 ABC-ATPase subunit interface; other site 696749004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749004810 dimer interface [polypeptide binding]; other site 696749004811 conserved gate region; other site 696749004812 putative PBP binding loops; other site 696749004813 ABC-ATPase subunit interface; other site 696749004814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004815 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 696749004816 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 696749004817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749004818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749004819 catalytic residue [active] 696749004820 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 696749004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004822 benzoate transport; Region: 2A0115; TIGR00895 696749004823 putative substrate translocation pore; other site 696749004824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749004825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749004826 active site 696749004827 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 696749004828 CoA-transferase family III; Region: CoA_transf_3; pfam02515 696749004829 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004830 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749004831 Helix-turn-helix domains; Region: HTH; cl00088 696749004832 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749004833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749004834 enoyl-CoA hydratase; Provisional; Region: PRK06688 696749004835 substrate binding site [chemical binding]; other site 696749004836 oxyanion hole (OAH) forming residues; other site 696749004837 trimer interface [polypeptide binding]; other site 696749004838 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 696749004839 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 696749004840 FMN binding site [chemical binding]; other site 696749004841 substrate binding site [chemical binding]; other site 696749004842 putative catalytic residue [active] 696749004843 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 696749004844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004845 putative substrate translocation pore; other site 696749004846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749004847 Helix-turn-helix domains; Region: HTH; cl00088 696749004848 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749004849 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 696749004850 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749004851 dimer interface [polypeptide binding]; other site 696749004852 active site 696749004853 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 696749004854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749004855 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749004856 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749004857 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 696749004858 classical (c) SDRs; Region: SDR_c; cd05233 696749004859 NAD(P) binding site [chemical binding]; other site 696749004860 active site 696749004861 enoyl-CoA hydratase; Provisional; Region: PRK08138 696749004862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749004863 substrate binding site [chemical binding]; other site 696749004864 oxyanion hole (OAH) forming residues; other site 696749004865 trimer interface [polypeptide binding]; other site 696749004866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749004867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749004868 active site 696749004869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004870 benzoate transport; Region: 2A0115; TIGR00895 696749004871 putative substrate translocation pore; other site 696749004872 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749004873 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749004874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749004875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749004876 putative substrate translocation pore; other site 696749004877 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749004878 CoenzymeA binding site [chemical binding]; other site 696749004879 subunit interaction site [polypeptide binding]; other site 696749004880 PHB binding site; other site 696749004881 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 696749004882 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 696749004883 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749004884 active site 696749004885 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 696749004886 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 696749004887 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 696749004888 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 696749004889 dimer interface [polypeptide binding]; other site 696749004890 PYR/PP interface [polypeptide binding]; other site 696749004891 TPP binding site [chemical binding]; other site 696749004892 substrate binding site [chemical binding]; other site 696749004893 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 696749004894 TPP-binding site [chemical binding]; other site 696749004895 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 696749004896 transcriptional regulator; Provisional; Region: PRK10632 696749004897 Helix-turn-helix domains; Region: HTH; cl00088 696749004898 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749004899 putative effector binding pocket; other site 696749004900 dimerization interface [polypeptide binding]; other site 696749004901 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 696749004902 active site 696749004903 catalytic residues [active] 696749004904 metal binding site [ion binding]; metal-binding site 696749004905 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 696749004906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749004907 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749004908 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 696749004909 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696749004910 carboxyltransferase (CT) interaction site; other site 696749004911 biotinylation site [posttranslational modification]; other site 696749004912 enoyl-CoA hydratase; Provisional; Region: PRK05995 696749004913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749004914 substrate binding site [chemical binding]; other site 696749004915 oxyanion hole (OAH) forming residues; other site 696749004916 trimer interface [polypeptide binding]; other site 696749004917 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 696749004918 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749004919 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749004920 isovaleryl-CoA dehydrogenase; Region: PLN02519 696749004921 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 696749004922 substrate binding site [chemical binding]; other site 696749004923 FAD binding site [chemical binding]; other site 696749004924 catalytic base [active] 696749004925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749004926 Helix-turn-helix domains; Region: HTH; cl00088 696749004927 AMP-binding domain protein; Validated; Region: PRK08315 696749004928 AMP-binding enzyme; Region: AMP-binding; cl15778 696749004929 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749004930 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 696749004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749004932 S-adenosylmethionine binding site [chemical binding]; other site 696749004933 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 696749004934 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 696749004935 active site 696749004936 catalytic triad [active] 696749004937 oxyanion hole [active] 696749004938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749004939 Helix-turn-helix domains; Region: HTH; cl00088 696749004940 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749004941 putative effector binding pocket; other site 696749004942 dimerization interface [polypeptide binding]; other site 696749004943 Competence-damaged protein; Region: CinA; cl00666 696749004944 hydroperoxidase II; Provisional; Region: katE; PRK11249 696749004945 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 696749004946 tetramer interface [polypeptide binding]; other site 696749004947 heme binding pocket [chemical binding]; other site 696749004948 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 696749004949 domain interactions; other site 696749004950 short chain dehydrogenase; Provisional; Region: PRK06701 696749004951 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 696749004952 NAD binding site [chemical binding]; other site 696749004953 metal binding site [ion binding]; metal-binding site 696749004954 active site 696749004955 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004957 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 696749004958 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749004959 Catalytic site [active] 696749004960 LysE type translocator; Region: LysE; cl00565 696749004961 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 696749004962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749004963 putative DNA binding site [nucleotide binding]; other site 696749004964 putative Zn2+ binding site [ion binding]; other site 696749004965 AsnC family; Region: AsnC_trans_reg; pfam01037 696749004966 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749004967 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749004968 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749004969 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749004970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749004971 dimer interface [polypeptide binding]; other site 696749004972 phosphorylation site [posttranslational modification] 696749004973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749004974 ATP binding site [chemical binding]; other site 696749004975 Mg2+ binding site [ion binding]; other site 696749004976 G-X-G motif; other site 696749004977 Response regulator receiver domain; Region: Response_reg; pfam00072 696749004978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749004979 active site 696749004980 phosphorylation site [posttranslational modification] 696749004981 intermolecular recognition site; other site 696749004982 dimerization interface [polypeptide binding]; other site 696749004983 Response regulator receiver domain; Region: Response_reg; pfam00072 696749004984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749004985 active site 696749004986 phosphorylation site [posttranslational modification] 696749004987 intermolecular recognition site; other site 696749004988 dimerization interface [polypeptide binding]; other site 696749004989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696749004990 DNA binding residues [nucleotide binding] 696749004991 dimerization interface [polypeptide binding]; other site 696749004992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749004993 Coenzyme A binding pocket [chemical binding]; other site 696749004994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749004995 dimer interface [polypeptide binding]; other site 696749004996 conserved gate region; other site 696749004997 putative PBP binding loops; other site 696749004998 ABC-ATPase subunit interface; other site 696749004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005000 dimer interface [polypeptide binding]; other site 696749005001 conserved gate region; other site 696749005002 putative PBP binding loops; other site 696749005003 ABC-ATPase subunit interface; other site 696749005004 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 696749005005 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 696749005006 Walker A/P-loop; other site 696749005007 ATP binding site [chemical binding]; other site 696749005008 Q-loop/lid; other site 696749005009 ABC transporter signature motif; other site 696749005010 Walker B; other site 696749005011 D-loop; other site 696749005012 H-loop/switch region; other site 696749005013 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 696749005014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749005015 substrate binding pocket [chemical binding]; other site 696749005016 membrane-bound complex binding site; other site 696749005017 hinge residues; other site 696749005018 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 696749005019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749005020 substrate binding pocket [chemical binding]; other site 696749005021 membrane-bound complex binding site; other site 696749005022 hinge residues; other site 696749005023 LysR family transcriptional regulator; Provisional; Region: PRK14997 696749005024 Helix-turn-helix domains; Region: HTH; cl00088 696749005025 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749005026 putative effector binding pocket; other site 696749005027 dimerization interface [polypeptide binding]; other site 696749005028 LysE type translocator; Region: LysE; cl00565 696749005029 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 696749005030 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 696749005031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749005032 catalytic residue [active] 696749005033 serine O-acetyltransferase; Region: PLN02694 696749005034 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 696749005035 trimer interface [polypeptide binding]; other site 696749005036 active site 696749005037 substrate binding site [chemical binding]; other site 696749005038 CoA binding site [chemical binding]; other site 696749005039 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 696749005040 active site residue [active] 696749005041 short chain dehydrogenase; Provisional; Region: PRK12937 696749005042 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 696749005043 NADP binding site [chemical binding]; other site 696749005044 homodimer interface [polypeptide binding]; other site 696749005045 active site 696749005046 substrate binding site [chemical binding]; other site 696749005047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005048 Helix-turn-helix domains; Region: HTH; cl00088 696749005049 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 696749005050 putative effector binding pocket; other site 696749005051 putative dimerization interface [polypeptide binding]; other site 696749005052 putative S-transferase; Provisional; Region: PRK11752 696749005053 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 696749005054 C-terminal domain interface [polypeptide binding]; other site 696749005055 GSH binding site (G-site) [chemical binding]; other site 696749005056 dimer interface [polypeptide binding]; other site 696749005057 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 696749005058 dimer interface [polypeptide binding]; other site 696749005059 N-terminal domain interface [polypeptide binding]; other site 696749005060 active site 696749005061 glutathione S-transferase; Provisional; Region: PRK15113 696749005062 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 696749005063 C-terminal domain interface [polypeptide binding]; other site 696749005064 GSH binding site (G-site) [chemical binding]; other site 696749005065 dimer interface [polypeptide binding]; other site 696749005066 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 696749005067 putative dimer interface [polypeptide binding]; other site 696749005068 N-terminal domain interface [polypeptide binding]; other site 696749005069 putative substrate binding pocket (H-site) [chemical binding]; other site 696749005070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005071 Helix-turn-helix domains; Region: HTH; cl00088 696749005072 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 696749005073 putative dimerization interface [polypeptide binding]; other site 696749005074 LrgA family; Region: LrgA; cl00608 696749005075 LrgB-like family; Region: LrgB; cl00596 696749005076 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749005077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749005078 DNA-binding site [nucleotide binding]; DNA binding site 696749005079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749005080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005081 homodimer interface [polypeptide binding]; other site 696749005082 catalytic residue [active] 696749005083 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 696749005084 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 696749005085 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749005086 potential frameshift: common BLAST hit: gi|184157779|ref|YP_001846118.1| major facilitator superfamily permease 696749005087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005088 putative substrate translocation pore; other site 696749005089 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 696749005090 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 696749005091 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 696749005092 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749005093 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749005094 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 696749005095 Acyl transferase domain; Region: Acyl_transf_1; cl08282 696749005096 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 696749005097 Malonate transporter MadL subunit; Region: MadL; cl04273 696749005098 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 696749005099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005100 Helix-turn-helix domains; Region: HTH; cl00088 696749005101 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 696749005102 putative dimerization interface [polypeptide binding]; other site 696749005103 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749005104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749005105 DNA-binding site [nucleotide binding]; DNA binding site 696749005106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749005107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005108 homodimer interface [polypeptide binding]; other site 696749005109 catalytic residue [active] 696749005110 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 696749005111 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 696749005112 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 696749005113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749005114 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 696749005115 active site 696749005116 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 696749005117 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 696749005118 active site 696749005119 non-prolyl cis peptide bond; other site 696749005120 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 696749005121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005122 putative substrate translocation pore; other site 696749005123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749005124 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749005125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749005126 substrate binding pocket [chemical binding]; other site 696749005127 membrane-bound complex binding site; other site 696749005128 hinge residues; other site 696749005129 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 696749005130 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 696749005131 Walker A/P-loop; other site 696749005132 ATP binding site [chemical binding]; other site 696749005133 Q-loop/lid; other site 696749005134 ABC transporter signature motif; other site 696749005135 Walker B; other site 696749005136 D-loop; other site 696749005137 H-loop/switch region; other site 696749005138 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 696749005139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005140 dimer interface [polypeptide binding]; other site 696749005141 conserved gate region; other site 696749005142 putative PBP binding loops; other site 696749005143 ABC-ATPase subunit interface; other site 696749005144 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 696749005145 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 696749005146 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 696749005147 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 696749005148 Na binding site [ion binding]; other site 696749005149 putative substrate binding site [chemical binding]; other site 696749005150 Transcriptional regulators [Transcription]; Region: GntR; COG1802 696749005151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749005152 DNA-binding site [nucleotide binding]; DNA binding site 696749005153 FCD domain; Region: FCD; cl11656 696749005154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005155 Helix-turn-helix domains; Region: HTH; cl00088 696749005156 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749005157 putative effector binding pocket; other site 696749005158 dimerization interface [polypeptide binding]; other site 696749005159 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 696749005160 Isochorismatase family; Region: Isochorismatase; pfam00857 696749005161 catalytic triad [active] 696749005162 dimer interface [polypeptide binding]; other site 696749005163 conserved cis-peptide bond; other site 696749005164 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 696749005165 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 696749005166 active site 696749005167 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 696749005168 catalytic residues [active] 696749005169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749005170 dimerization interface [polypeptide binding]; other site 696749005171 putative DNA binding site [nucleotide binding]; other site 696749005172 putative Zn2+ binding site [ion binding]; other site 696749005173 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 696749005174 Membrane transport protein; Region: Mem_trans; cl09117 696749005175 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749005176 Helix-turn-helix domains; Region: HTH; cl00088 696749005177 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 696749005178 putative dimerization interface [polypeptide binding]; other site 696749005179 putative substrate binding pocket [chemical binding]; other site 696749005180 Chromate transporter; Region: Chromate_transp; pfam02417 696749005181 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 696749005182 Chromate transporter; Region: Chromate_transp; pfam02417 696749005183 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 696749005184 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 696749005185 catalytic residue [active] 696749005186 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 696749005187 catalytic residues [active] 696749005188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749005189 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 696749005190 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749005191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696749005192 TPR motif; other site 696749005193 binding surface 696749005194 serine O-acetyltransferase; Region: cysE; TIGR01172 696749005195 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 696749005196 trimer interface [polypeptide binding]; other site 696749005197 active site 696749005198 substrate binding site [chemical binding]; other site 696749005199 CoA binding site [chemical binding]; other site 696749005200 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 696749005201 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 696749005202 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 696749005203 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 696749005204 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 696749005205 generic binding surface II; other site 696749005206 generic binding surface I; other site 696749005207 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 696749005208 active site 696749005209 homodimer interface [polypeptide binding]; other site 696749005210 homotetramer interface [polypeptide binding]; other site 696749005211 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749005212 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749005213 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 696749005214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749005215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005216 homodimer interface [polypeptide binding]; other site 696749005217 catalytic residue [active] 696749005218 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 696749005219 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 696749005220 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 696749005221 catalytic residues [active] 696749005222 dimer interface [polypeptide binding]; other site 696749005223 Cupin domain; Region: Cupin_2; cl09118 696749005224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749005225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005227 LysE type translocator; Region: LysE; cl00565 696749005228 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 696749005229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749005230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005231 homodimer interface [polypeptide binding]; other site 696749005232 catalytic residue [active] 696749005233 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 696749005234 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696749005235 metal binding triad; other site 696749005236 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 696749005237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749005238 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 696749005239 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 696749005240 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 696749005241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005242 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749005243 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 696749005244 trimer interface [polypeptide binding]; other site 696749005245 putative substrate binding pocket [chemical binding]; other site 696749005246 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 696749005247 putative L-valine exporter; Provisional; Region: PRK10408 696749005248 AzlC protein; Region: AzlC; cl00570 696749005249 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 696749005250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 696749005251 ligand binding site [chemical binding]; other site 696749005252 flexible hinge region; other site 696749005253 Helix-turn-helix domains; Region: HTH; cl00088 696749005254 Protein of unknown function (DUF962); Region: DUF962; cl01879 696749005255 GTP-binding protein YchF; Reviewed; Region: PRK09601 696749005256 YchF GTPase; Region: YchF; cd01900 696749005257 G1 box; other site 696749005258 GTP/Mg2+ binding site [chemical binding]; other site 696749005259 Switch I region; other site 696749005260 G2 box; other site 696749005261 Switch II region; other site 696749005262 G3 box; other site 696749005263 G4 box; other site 696749005264 G5 box; other site 696749005265 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 696749005266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005267 dimer interface [polypeptide binding]; other site 696749005268 conserved gate region; other site 696749005269 ABC-ATPase subunit interface; other site 696749005270 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 696749005271 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 696749005272 Walker A/P-loop; other site 696749005273 ATP binding site [chemical binding]; other site 696749005274 Q-loop/lid; other site 696749005275 ABC transporter signature motif; other site 696749005276 Walker B; other site 696749005277 D-loop; other site 696749005278 H-loop/switch region; other site 696749005279 NIL domain; Region: NIL; cl09633 696749005280 NMT1-like family; Region: NMT1_2; cl15260 696749005281 NMT1-like family; Region: NMT1_2; cl15260 696749005282 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 696749005283 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 696749005284 active site 696749005285 non-prolyl cis peptide bond; other site 696749005286 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 696749005287 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 696749005288 Flavin binding site [chemical binding]; other site 696749005289 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 696749005290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749005291 active site 696749005292 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 696749005293 C-terminal domain interface [polypeptide binding]; other site 696749005294 GSH binding site (G-site) [chemical binding]; other site 696749005295 dimer interface [polypeptide binding]; other site 696749005296 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 696749005297 N-terminal domain interface [polypeptide binding]; other site 696749005298 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 696749005299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696749005300 substrate binding pocket [chemical binding]; other site 696749005301 membrane-bound complex binding site; other site 696749005302 hinge residues; other site 696749005303 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696749005304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005305 dimer interface [polypeptide binding]; other site 696749005306 conserved gate region; other site 696749005307 putative PBP binding loops; other site 696749005308 ABC-ATPase subunit interface; other site 696749005309 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696749005310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005311 dimer interface [polypeptide binding]; other site 696749005312 conserved gate region; other site 696749005313 putative PBP binding loops; other site 696749005314 ABC-ATPase subunit interface; other site 696749005315 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 696749005316 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 696749005317 Walker A/P-loop; other site 696749005318 ATP binding site [chemical binding]; other site 696749005319 Q-loop/lid; other site 696749005320 ABC transporter signature motif; other site 696749005321 Walker B; other site 696749005322 D-loop; other site 696749005323 H-loop/switch region; other site 696749005324 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 696749005325 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 696749005326 Helix-turn-helix domains; Region: HTH; cl00088 696749005327 AsnC family; Region: AsnC_trans_reg; pfam01037 696749005328 Transcriptional regulator; Region: Transcrip_reg; cl00361 696749005329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 696749005330 putative acyl-acceptor binding pocket; other site 696749005331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749005332 Helix-turn-helix domains; Region: HTH; cl00088 696749005333 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749005334 active site 696749005335 Int/Topo IB signature motif; other site 696749005336 DNA binding site [nucleotide binding] 696749005337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005338 Helix-turn-helix domains; Region: HTH; cl00088 696749005339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749005340 dimerization interface [polypeptide binding]; other site 696749005341 Predicted membrane protein [Function unknown]; Region: COG4125 696749005342 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696749005343 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696749005344 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749005345 Na binding site [ion binding]; other site 696749005346 EamA-like transporter family; Region: EamA; cl01037 696749005347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005348 Helix-turn-helix domains; Region: HTH; cl00088 696749005349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749005350 dimerization interface [polypeptide binding]; other site 696749005351 putative major fimbrial protein SthE; Provisional; Region: PRK15292 696749005352 Fimbrial protein; Region: Fimbrial; cl01416 696749005353 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 696749005354 PapC N-terminal domain; Region: PapC_N; pfam13954 696749005355 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 696749005356 PapC C-terminal domain; Region: PapC_C; pfam13953 696749005357 putative chaperone protein EcpD; Provisional; Region: PRK09926 696749005358 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 696749005359 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 696749005360 Fimbrial protein; Region: Fimbrial; cl01416 696749005361 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749005362 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749005363 biotin synthase; Provisional; Region: PRK15108 696749005364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749005365 FeS/SAM binding site; other site 696749005366 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 696749005367 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 696749005368 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 696749005369 putative carbohydrate kinase; Provisional; Region: PRK10565 696749005370 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 696749005371 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 696749005372 putative substrate binding site [chemical binding]; other site 696749005373 putative ATP binding site [chemical binding]; other site 696749005374 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 696749005375 active site 696749005376 putative DNA-binding cleft [nucleotide binding]; other site 696749005377 dimer interface [polypeptide binding]; other site 696749005378 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 696749005379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749005380 non-specific DNA binding site [nucleotide binding]; other site 696749005381 salt bridge; other site 696749005382 sequence-specific DNA binding site [nucleotide binding]; other site 696749005383 Cupin domain; Region: Cupin_2; cl09118 696749005384 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 696749005385 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749005386 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749005387 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749005388 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 696749005389 S-adenosylmethionine synthetase; Validated; Region: PRK05250 696749005390 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 696749005391 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 696749005392 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 696749005393 transketolase; Reviewed; Region: PRK12753 696749005394 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 696749005395 TPP-binding site [chemical binding]; other site 696749005396 dimer interface [polypeptide binding]; other site 696749005397 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 696749005398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 696749005399 PYR/PP interface [polypeptide binding]; other site 696749005400 dimer interface [polypeptide binding]; other site 696749005401 TPP binding site [chemical binding]; other site 696749005402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696749005403 OsmC-like protein; Region: OsmC; cl00767 696749005404 YceI-like domain; Region: YceI; cl01001 696749005405 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 696749005406 Predicted periplasmic protein [Function unknown]; Region: COG3698 696749005407 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 696749005408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749005409 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 696749005410 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 696749005411 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 696749005412 Proline dehydrogenase; Region: Pro_dh; cl03282 696749005413 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 696749005414 Glutamate binding site [chemical binding]; other site 696749005415 NAD binding site [chemical binding]; other site 696749005416 catalytic residues [active] 696749005417 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 696749005418 Helix-turn-helix domains; Region: HTH; cl00088 696749005419 AsnC family; Region: AsnC_trans_reg; pfam01037 696749005420 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 696749005421 Na binding site [ion binding]; other site 696749005422 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 696749005423 NAD+ binding site [chemical binding]; other site 696749005424 substrate binding site [chemical binding]; other site 696749005425 Zn binding site [ion binding]; other site 696749005426 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 696749005427 lipoyl attachment site [posttranslational modification]; other site 696749005428 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749005429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749005430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005431 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 696749005432 putative active site [active] 696749005433 putative catalytic site [active] 696749005434 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 696749005435 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 696749005436 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 696749005437 Walker A/P-loop; other site 696749005438 ATP binding site [chemical binding]; other site 696749005439 Q-loop/lid; other site 696749005440 ABC transporter signature motif; other site 696749005441 Walker B; other site 696749005442 D-loop; other site 696749005443 H-loop/switch region; other site 696749005444 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 696749005445 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 696749005446 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749005447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749005448 dimerization interface [polypeptide binding]; other site 696749005449 putative DNA binding site [nucleotide binding]; other site 696749005450 putative Zn2+ binding site [ion binding]; other site 696749005451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749005452 Helix-turn-helix domains; Region: HTH; cl00088 696749005453 Cupin superfamily protein; Region: Cupin_4; pfam08007 696749005454 JmjC domain, hydroxylase; Region: JmjC; cl15814 696749005455 Maf-like protein; Region: Maf; pfam02545 696749005456 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 696749005457 active site 696749005458 dimer interface [polypeptide binding]; other site 696749005459 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 696749005460 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 696749005461 Phosphoglycerate kinase; Region: PGK; pfam00162 696749005462 substrate binding site [chemical binding]; other site 696749005463 hinge regions; other site 696749005464 ADP binding site [chemical binding]; other site 696749005465 catalytic site [active] 696749005466 hypothetical protein; Provisional; Region: PRK08185 696749005467 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 696749005468 intersubunit interface [polypeptide binding]; other site 696749005469 active site 696749005470 zinc binding site [ion binding]; other site 696749005471 Na+ binding site [ion binding]; other site 696749005472 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 696749005473 SurA N-terminal domain; Region: SurA_N_3; cl07813 696749005474 PPIC-type PPIASE domain; Region: Rotamase; cl08278 696749005475 PPIC-type PPIASE domain; Region: Rotamase; cl08278 696749005476 OstA-like protein; Region: OstA; cl00844 696749005477 Organic solvent tolerance protein; Region: OstA_C; pfam04453 696749005478 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749005479 Phosphotransferase enzyme family; Region: APH; pfam01636 696749005480 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 696749005481 Substrate binding site; other site 696749005482 metal-binding site 696749005483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749005484 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 696749005485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749005486 P-loop; other site 696749005487 Magnesium ion binding site [ion binding]; other site 696749005488 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749005489 Magnesium ion binding site [ion binding]; other site 696749005490 ParB-like partition proteins; Region: parB_part; TIGR00180 696749005491 ParB-like nuclease domain; Region: ParBc; cl02129 696749005492 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 696749005493 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696749005494 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 696749005495 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 696749005496 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 696749005497 Walker A/P-loop; other site 696749005498 ATP binding site [chemical binding]; other site 696749005499 Q-loop/lid; other site 696749005500 ABC transporter signature motif; other site 696749005501 Walker B; other site 696749005502 D-loop; other site 696749005503 H-loop/switch region; other site 696749005504 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 696749005505 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 696749005506 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 696749005507 Ligand binding site; other site 696749005508 oligomer interface; other site 696749005509 DNA polymerase III subunit delta'; Validated; Region: PRK05707 696749005510 PilZ domain; Region: PilZ; cl01260 696749005511 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 696749005512 active site 696749005513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749005514 Helix-turn-helix domains; Region: HTH; cl00088 696749005515 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 696749005516 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 696749005517 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 696749005518 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 696749005519 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 696749005520 ligand binding site [chemical binding]; other site 696749005521 active site 696749005522 UGI interface [polypeptide binding]; other site 696749005523 catalytic site [active] 696749005524 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 696749005525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749005526 substrate binding site [chemical binding]; other site 696749005527 oxyanion hole (OAH) forming residues; other site 696749005528 trimer interface [polypeptide binding]; other site 696749005529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 696749005530 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 696749005531 nucleoside/Zn binding site; other site 696749005532 dimer interface [polypeptide binding]; other site 696749005533 catalytic motif [active] 696749005534 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 696749005535 putative hydrophobic ligand binding site [chemical binding]; other site 696749005536 protein interface [polypeptide binding]; other site 696749005537 gate; other site 696749005538 cytidylate kinase; Provisional; Region: cmk; PRK00023 696749005539 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 696749005540 CMP-binding site; other site 696749005541 The sites determining sugar specificity; other site 696749005542 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 696749005543 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 696749005544 RNA binding site [nucleotide binding]; other site 696749005545 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 696749005546 RNA binding site [nucleotide binding]; other site 696749005547 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 696749005548 RNA binding site [nucleotide binding]; other site 696749005549 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 696749005550 RNA binding site [nucleotide binding]; other site 696749005551 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 696749005552 RNA binding site [nucleotide binding]; other site 696749005553 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 696749005554 RNA binding site [nucleotide binding]; other site 696749005555 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696749005556 IHF dimer interface [polypeptide binding]; other site 696749005557 IHF - DNA interface [nucleotide binding]; other site 696749005558 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 696749005559 active site 696749005560 dimer interface [polypeptide binding]; other site 696749005561 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 696749005562 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749005563 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749005564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749005565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005566 Predicted ATPase [General function prediction only]; Region: COG1485 696749005567 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 696749005568 active site 696749005569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749005570 Coenzyme A binding pocket [chemical binding]; other site 696749005571 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696749005572 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696749005573 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 696749005574 Gram-negative bacterial tonB protein; Region: TonB; cl10048 696749005575 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696749005576 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749005577 N-terminal plug; other site 696749005578 ligand-binding site [chemical binding]; other site 696749005579 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 696749005580 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 696749005581 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 696749005582 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 696749005583 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 696749005584 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 696749005585 active site 696749005586 Zn binding site [ion binding]; other site 696749005587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 696749005588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005589 dimer interface [polypeptide binding]; other site 696749005590 conserved gate region; other site 696749005591 putative PBP binding loops; other site 696749005592 ABC-ATPase subunit interface; other site 696749005593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005594 dimer interface [polypeptide binding]; other site 696749005595 conserved gate region; other site 696749005596 putative PBP binding loops; other site 696749005597 ABC-ATPase subunit interface; other site 696749005598 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 696749005599 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 696749005600 Walker A/P-loop; other site 696749005601 ATP binding site [chemical binding]; other site 696749005602 Q-loop/lid; other site 696749005603 ABC transporter signature motif; other site 696749005604 Walker B; other site 696749005605 D-loop; other site 696749005606 H-loop/switch region; other site 696749005607 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 696749005608 Walker A/P-loop; other site 696749005609 ATP binding site [chemical binding]; other site 696749005610 Q-loop/lid; other site 696749005611 ABC transporter signature motif; other site 696749005612 Walker B; other site 696749005613 D-loop; other site 696749005614 H-loop/switch region; other site 696749005615 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696749005616 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 696749005617 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 696749005618 active site 696749005619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696749005620 catalytic core [active] 696749005621 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 696749005622 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 696749005623 NAD binding site [chemical binding]; other site 696749005624 active site 696749005625 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 696749005626 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 696749005627 putative C-terminal domain interface [polypeptide binding]; other site 696749005628 putative GSH binding site (G-site) [chemical binding]; other site 696749005629 putative dimer interface [polypeptide binding]; other site 696749005630 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 696749005631 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 696749005632 transcription-repair coupling factor; Provisional; Region: PRK10689 696749005633 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 696749005634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749005635 ATP binding site [chemical binding]; other site 696749005636 putative Mg++ binding site [ion binding]; other site 696749005637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749005638 nucleotide binding region [chemical binding]; other site 696749005639 ATP-binding site [chemical binding]; other site 696749005640 TRCF domain; Region: TRCF; cl04088 696749005641 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 696749005642 cyclase homology domain; Region: CHD; cd07302 696749005643 nucleotidyl binding site; other site 696749005644 metal binding site [ion binding]; metal-binding site 696749005645 dimer interface [polypeptide binding]; other site 696749005646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749005647 catalytic loop [active] 696749005648 iron binding site [ion binding]; other site 696749005649 chaperone protein HscA; Provisional; Region: hscA; PRK05183 696749005650 co-chaperone HscB; Provisional; Region: hscB; PRK05014 696749005651 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 696749005652 HSP70 interaction site [polypeptide binding]; other site 696749005653 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 696749005654 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 696749005655 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 696749005656 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 696749005657 trimerization site [polypeptide binding]; other site 696749005658 active site 696749005659 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749005660 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 696749005661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749005662 catalytic residue [active] 696749005663 Helix-turn-helix domains; Region: HTH; cl00088 696749005664 Rrf2 family protein; Region: rrf2_super; TIGR00738 696749005665 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 696749005666 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696749005667 IHF dimer interface [polypeptide binding]; other site 696749005668 IHF - DNA interface [nucleotide binding]; other site 696749005669 periplasmic folding chaperone; Provisional; Region: PRK10788 696749005670 SurA N-terminal domain; Region: SurA_N_3; cl07813 696749005671 PPIC-type PPIASE domain; Region: Rotamase; cl08278 696749005672 Cupin domain; Region: Cupin_2; cl09118 696749005673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749005674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005675 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 696749005676 Di-iron ligands [ion binding]; other site 696749005677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749005678 active site 696749005679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749005680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749005681 active site 696749005682 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749005683 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 696749005684 putative deacylase active site [active] 696749005685 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 696749005686 IucA / IucC family; Region: IucA_IucC; pfam04183 696749005687 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 696749005688 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 696749005689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749005692 putative substrate translocation pore; other site 696749005693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005694 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 696749005695 IucA / IucC family; Region: IucA_IucC; pfam04183 696749005696 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 696749005697 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 696749005698 IucA / IucC family; Region: IucA_IucC; pfam04183 696749005699 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 696749005700 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 696749005701 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 696749005702 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749005703 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749005704 N-terminal plug; other site 696749005705 ligand-binding site [chemical binding]; other site 696749005706 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 696749005707 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749005708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 696749005709 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 696749005710 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 696749005711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749005712 motif II; other site 696749005713 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 696749005714 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 696749005715 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 696749005716 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 696749005717 homotrimer interface [polypeptide binding]; other site 696749005718 Walker A motif; other site 696749005719 GTP binding site [chemical binding]; other site 696749005720 Walker B motif; other site 696749005721 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 696749005722 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 696749005723 putative dimer interface [polypeptide binding]; other site 696749005724 active site pocket [active] 696749005725 putative cataytic base [active] 696749005726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696749005727 catalytic core [active] 696749005728 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 696749005729 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 696749005730 NeuB family; Region: NeuB; cl00496 696749005731 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696749005732 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696749005733 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749005734 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749005735 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 696749005736 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749005737 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 696749005738 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749005739 N-terminal plug; other site 696749005740 ligand-binding site [chemical binding]; other site 696749005741 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 696749005742 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696749005743 Helix-turn-helix domains; Region: HTH; cl00088 696749005744 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 696749005745 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 696749005746 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749005747 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749005748 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 696749005749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749005750 Walker A/P-loop; other site 696749005751 ATP binding site [chemical binding]; other site 696749005752 Q-loop/lid; other site 696749005753 ABC transporter signature motif; other site 696749005754 Walker B; other site 696749005755 D-loop; other site 696749005756 H-loop/switch region; other site 696749005757 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 696749005758 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 696749005759 Walker A/P-loop; other site 696749005760 ATP binding site [chemical binding]; other site 696749005761 Q-loop/lid; other site 696749005762 ABC transporter signature motif; other site 696749005763 Walker B; other site 696749005764 D-loop; other site 696749005765 H-loop/switch region; other site 696749005766 ABC-2 type transporter; Region: ABC2_membrane; cl11417 696749005767 ABC-2 type transporter; Region: ABC2_membrane; cl11417 696749005768 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 696749005769 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 696749005770 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 696749005771 eyelet of channel; other site 696749005772 trimer interface [polypeptide binding]; other site 696749005773 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 696749005774 HIT family signature motif; other site 696749005775 catalytic residue [active] 696749005776 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 696749005777 Gram-negative bacterial tonB protein; Region: TonB; cl10048 696749005778 phosphoethanolamine N-methyltransferase; Region: PLN02336 696749005779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749005780 S-adenosylmethionine binding site [chemical binding]; other site 696749005781 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 696749005782 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 696749005783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 696749005784 homodimer interface [polypeptide binding]; other site 696749005785 substrate-cofactor binding pocket; other site 696749005786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005787 catalytic residue [active] 696749005788 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 696749005789 recombination protein RecR; Reviewed; Region: recR; PRK00076 696749005790 RecR protein; Region: RecR; pfam02132 696749005791 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 696749005792 putative active site [active] 696749005793 putative metal-binding site [ion binding]; other site 696749005794 tetramer interface [polypeptide binding]; other site 696749005795 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 696749005796 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 696749005797 catalytic site [active] 696749005798 putative active site [active] 696749005799 putative substrate binding site [chemical binding]; other site 696749005800 HRDC domain; Region: HRDC; cl02578 696749005801 YcgL domain; Region: YcgL; cl01189 696749005802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749005803 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 696749005804 Walker A motif; other site 696749005805 ATP binding site [chemical binding]; other site 696749005806 Walker B motif; other site 696749005807 arginine finger; other site 696749005808 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 696749005809 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 696749005810 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 696749005811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749005812 catalytic residue [active] 696749005813 HemK family putative methylases; Region: hemK_fam; TIGR00536 696749005814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749005815 S-adenosylmethionine binding site [chemical binding]; other site 696749005816 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 696749005817 Tetramer interface [polypeptide binding]; other site 696749005818 active site 696749005819 FMN-binding site [chemical binding]; other site 696749005820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749005821 metal binding site [ion binding]; metal-binding site 696749005822 active site 696749005823 I-site; other site 696749005824 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 696749005825 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 696749005826 Helix-turn-helix domains; Region: HTH; cl00088 696749005827 lipoyl synthase; Provisional; Region: PRK12928 696749005828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749005829 FeS/SAM binding site; other site 696749005830 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 696749005831 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 696749005832 tetramer interface [polypeptide binding]; other site 696749005833 TPP-binding site [chemical binding]; other site 696749005834 heterodimer interface [polypeptide binding]; other site 696749005835 phosphorylation loop region [posttranslational modification] 696749005836 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 696749005837 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 696749005838 alpha subunit interface [polypeptide binding]; other site 696749005839 TPP binding site [chemical binding]; other site 696749005840 heterodimer interface [polypeptide binding]; other site 696749005841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696749005842 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 696749005843 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696749005844 E3 interaction surface; other site 696749005845 lipoyl attachment site [posttranslational modification]; other site 696749005846 e3 binding domain; Region: E3_binding; pfam02817 696749005847 e3 binding domain; Region: E3_binding; pfam02817 696749005848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 696749005849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005850 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 696749005851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749005852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696749005853 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 696749005854 acetoin reductases; Region: 23BDH; TIGR02415 696749005855 NAD binding site [chemical binding]; other site 696749005856 homotetramer interface [polypeptide binding]; other site 696749005857 homodimer interface [polypeptide binding]; other site 696749005858 active site 696749005859 substrate binding site [chemical binding]; other site 696749005860 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 696749005861 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 696749005862 putative NAD(P) binding site [chemical binding]; other site 696749005863 catalytic Zn binding site [ion binding]; other site 696749005864 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 696749005865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749005866 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 696749005867 Walker A motif; other site 696749005868 ATP binding site [chemical binding]; other site 696749005869 Walker B motif; other site 696749005870 arginine finger; other site 696749005871 Helix-turn-helix domains; Region: HTH; cl00088 696749005872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749005873 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 696749005874 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 696749005875 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749005876 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 696749005877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005878 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 696749005879 EamA-like transporter family; Region: EamA; cl01037 696749005880 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749005881 EamA-like transporter family; Region: EamA; cl01037 696749005882 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 696749005883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749005885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005886 Helix-turn-helix domains; Region: HTH; cl00088 696749005887 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749005888 Chromate transporter; Region: Chromate_transp; pfam02417 696749005889 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 696749005890 Chromate transporter; Region: Chromate_transp; pfam02417 696749005891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749005892 DNA-binding site [nucleotide binding]; DNA binding site 696749005893 UTRA domain; Region: UTRA; cl01230 696749005894 putative oxidoreductase; Provisional; Region: PRK08275 696749005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005896 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 696749005897 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 696749005898 NMT1-like family; Region: NMT1_2; cl15260 696749005899 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 696749005900 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 696749005901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005902 dimer interface [polypeptide binding]; other site 696749005903 conserved gate region; other site 696749005904 putative PBP binding loops; other site 696749005905 ABC-ATPase subunit interface; other site 696749005906 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 696749005907 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 696749005908 Walker A/P-loop; other site 696749005909 ATP binding site [chemical binding]; other site 696749005910 Q-loop/lid; other site 696749005911 ABC transporter signature motif; other site 696749005912 Walker B; other site 696749005913 D-loop; other site 696749005914 H-loop/switch region; other site 696749005915 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 696749005916 Protein of unknown function (DUF971); Region: DUF971; cl01414 696749005917 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 696749005918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005919 putative substrate translocation pore; other site 696749005920 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749005921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749005922 N-terminal plug; other site 696749005923 ligand-binding site [chemical binding]; other site 696749005924 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 696749005925 Aspartase; Region: Aspartase; cd01357 696749005926 active sites [active] 696749005927 tetramer interface [polypeptide binding]; other site 696749005928 cell density-dependent motility repressor; Provisional; Region: PRK10082 696749005929 Helix-turn-helix domains; Region: HTH; cl00088 696749005930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749005931 dimerization interface [polypeptide binding]; other site 696749005932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005933 Helix-turn-helix domains; Region: HTH; cl00088 696749005934 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 696749005935 substrate binding pocket [chemical binding]; other site 696749005936 dimerization interface [polypeptide binding]; other site 696749005937 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 696749005938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749005939 dimer interface [polypeptide binding]; other site 696749005940 active site 696749005941 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 696749005942 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749005943 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749005944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749005945 Helix-turn-helix domains; Region: HTH; cl00088 696749005946 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 696749005947 putative dimerization interface [polypeptide binding]; other site 696749005948 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 696749005949 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 696749005950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749005951 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 696749005952 NAD(P) binding site [chemical binding]; other site 696749005953 active site 696749005954 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749005955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005956 benzoate transport; Region: 2A0115; TIGR00895 696749005957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005958 putative substrate translocation pore; other site 696749005959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749005960 Dienelactone hydrolase family; Region: DLH; pfam01738 696749005961 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749005962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 696749005963 classical (c) SDRs; Region: SDR_c; cd05233 696749005964 NAD(P) binding site [chemical binding]; other site 696749005965 active site 696749005966 Flavin Reductases; Region: FlaRed; cl00801 696749005967 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 696749005968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005969 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749005970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749005971 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 696749005972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749005973 catalytic loop [active] 696749005974 iron binding site [ion binding]; other site 696749005975 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 696749005976 FAD binding pocket [chemical binding]; other site 696749005977 FAD binding motif [chemical binding]; other site 696749005978 phosphate binding motif [ion binding]; other site 696749005979 beta-alpha-beta structure motif; other site 696749005980 NAD binding pocket [chemical binding]; other site 696749005981 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 696749005982 inter-subunit interface; other site 696749005983 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 696749005984 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 696749005985 [2Fe-2S] cluster binding site [ion binding]; other site 696749005986 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 696749005987 putative alpha subunit interface [polypeptide binding]; other site 696749005988 putative active site [active] 696749005989 putative substrate binding site [chemical binding]; other site 696749005990 Fe binding site [ion binding]; other site 696749005991 Helix-turn-helix domains; Region: HTH; cl00088 696749005992 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 696749005993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749005994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749005995 dimer interface [polypeptide binding]; other site 696749005996 conserved gate region; other site 696749005997 putative PBP binding loops; other site 696749005998 ABC-ATPase subunit interface; other site 696749005999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749006000 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 696749006001 Walker A/P-loop; other site 696749006002 ATP binding site [chemical binding]; other site 696749006003 Q-loop/lid; other site 696749006004 ABC transporter signature motif; other site 696749006005 Walker B; other site 696749006006 D-loop; other site 696749006007 H-loop/switch region; other site 696749006008 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749006009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006010 NAD(P) binding site [chemical binding]; other site 696749006011 active site 696749006012 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 696749006013 hydrophobic substrate binding pocket; other site 696749006014 Isochorismatase family; Region: Isochorismatase; pfam00857 696749006015 active site 696749006016 conserved cis-peptide bond; other site 696749006017 Helix-turn-helix domains; Region: HTH; cl00088 696749006018 metal binding site 2 [ion binding]; metal-binding site 696749006019 putative DNA binding helix; other site 696749006020 metal binding site 1 [ion binding]; metal-binding site 696749006021 dimer interface [polypeptide binding]; other site 696749006022 structural Zn2+ binding site [ion binding]; other site 696749006023 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 696749006024 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 696749006025 putative active site [active] 696749006026 putative metal binding site [ion binding]; other site 696749006027 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 696749006028 polyphosphate kinase; Provisional; Region: PRK05443 696749006029 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 696749006030 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 696749006031 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 696749006032 putative active site [active] 696749006033 catalytic site [active] 696749006034 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 696749006035 putative domain interface [polypeptide binding]; other site 696749006036 putative active site [active] 696749006037 catalytic site [active] 696749006038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749006039 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 696749006040 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 696749006041 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 696749006042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749006043 FeS/SAM binding site; other site 696749006044 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 696749006045 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 696749006046 active site 696749006047 dimer interface [polypeptide binding]; other site 696749006048 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 696749006049 putative active site [active] 696749006050 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 696749006051 PLD-like domain; Region: PLDc_2; pfam13091 696749006052 putative active site [active] 696749006053 catalytic site [active] 696749006054 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 696749006055 putative active site [active] 696749006056 catalytic site [active] 696749006057 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 696749006058 putative heme binding pocket [chemical binding]; other site 696749006059 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 696749006060 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 696749006061 substrate binding site [chemical binding]; other site 696749006062 catalytic Zn binding site [ion binding]; other site 696749006063 NAD binding site [chemical binding]; other site 696749006064 structural Zn binding site [ion binding]; other site 696749006065 dimer interface [polypeptide binding]; other site 696749006066 Fimbrial protein; Region: Fimbrial; cl01416 696749006067 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 696749006068 PapC N-terminal domain; Region: PapC_N; pfam13954 696749006069 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 696749006070 PapC C-terminal domain; Region: PapC_C; pfam13953 696749006071 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 696749006072 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 696749006073 Fimbrial protein; Region: Fimbrial; cl01416 696749006074 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749006075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006076 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 696749006077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749006078 Helix-turn-helix domains; Region: HTH; cl00088 696749006079 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 696749006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006081 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 696749006082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006083 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749006084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006085 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749006086 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006087 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 696749006088 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 696749006089 Protein export membrane protein; Region: SecD_SecF; cl14618 696749006090 Protein export membrane protein; Region: SecD_SecF; cl14618 696749006091 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 696749006092 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006093 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 696749006095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749006096 active site 696749006097 phosphorylation site [posttranslational modification] 696749006098 intermolecular recognition site; other site 696749006099 dimerization interface [polypeptide binding]; other site 696749006100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749006101 DNA binding site [nucleotide binding] 696749006102 potential frameshift: common BLAST hit: gi|184158147|ref|YP_001846486.1| Signal transduction histidine kinase 696749006103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749006104 dimer interface [polypeptide binding]; other site 696749006105 phosphorylation site [posttranslational modification] 696749006106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749006107 ATP binding site [chemical binding]; other site 696749006108 Mg2+ binding site [ion binding]; other site 696749006109 G-X-G motif; other site 696749006110 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749006111 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 696749006112 Helix-turn-helix domains; Region: HTH; cl00088 696749006113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749006114 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749006115 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006116 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 696749006117 classical (c) SDRs; Region: SDR_c; cd05233 696749006118 NAD(P) binding site [chemical binding]; other site 696749006119 active site 696749006120 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 696749006121 classical (c) SDRs; Region: SDR_c; cd05233 696749006122 NAD(P) binding site [chemical binding]; other site 696749006123 active site 696749006124 PAAR motif; Region: PAAR_motif; cl15808 696749006125 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 696749006126 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749006127 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749006128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749006129 Helix-turn-helix domains; Region: HTH; cl00088 696749006130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749006131 non-specific DNA binding site [nucleotide binding]; other site 696749006132 salt bridge; other site 696749006133 sequence-specific DNA binding site [nucleotide binding]; other site 696749006134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749006135 Survival protein SurE; Region: SurE; cl00448 696749006136 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 696749006137 GH3 auxin-responsive promoter; Region: GH3; cl04006 696749006138 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 696749006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006140 putative substrate translocation pore; other site 696749006141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006142 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 696749006143 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006144 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006145 indole acetimide hydrolase; Validated; Region: PRK07488 696749006146 Amidase; Region: Amidase; cl11426 696749006147 potential frameshift: common BLAST hit: gi|184158171|ref|YP_001846510.1| DNA-binding HTH domain-containing protein 696749006148 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 696749006149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696749006150 DNA binding residues [nucleotide binding] 696749006151 dimerization interface [polypeptide binding]; other site 696749006152 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749006153 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749006154 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749006155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749006156 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 696749006157 FAD binding site [chemical binding]; other site 696749006158 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 696749006159 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 696749006160 nudix motif; other site 696749006161 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 696749006162 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 696749006163 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 696749006164 active site 696749006165 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 696749006166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749006167 active site 696749006168 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749006169 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696749006170 Cupin domain; Region: Cupin_2; cl09118 696749006171 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749006172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749006173 Coenzyme A binding pocket [chemical binding]; other site 696749006174 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 696749006175 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696749006176 Walker A/P-loop; other site 696749006177 ATP binding site [chemical binding]; other site 696749006178 Q-loop/lid; other site 696749006179 ABC transporter signature motif; other site 696749006180 Walker B; other site 696749006181 D-loop; other site 696749006182 H-loop/switch region; other site 696749006183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696749006184 ABC-ATPase subunit interface; other site 696749006185 dimer interface [polypeptide binding]; other site 696749006186 putative PBP binding regions; other site 696749006187 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 696749006188 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 696749006189 intersubunit interface [polypeptide binding]; other site 696749006190 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 696749006191 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 696749006192 putative NAD(P) binding site [chemical binding]; other site 696749006193 putative substrate binding site [chemical binding]; other site 696749006194 catalytic Zn binding site [ion binding]; other site 696749006195 structural Zn binding site [ion binding]; other site 696749006196 dimer interface [polypeptide binding]; other site 696749006197 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749006198 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749006199 Cupin domain; Region: Cupin_2; cl09118 696749006200 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 696749006201 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696749006202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749006203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749006204 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 696749006205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006206 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 696749006207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006208 putative substrate translocation pore; other site 696749006209 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 696749006210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006211 NAD(P) binding site [chemical binding]; other site 696749006212 active site 696749006213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749006214 Helix-turn-helix domains; Region: HTH; cl00088 696749006215 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 696749006216 putative dimerization interface [polypeptide binding]; other site 696749006217 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 696749006218 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 696749006219 Dehydratase family; Region: ILVD_EDD; cl00340 696749006220 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 696749006221 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 696749006222 dimer interface [polypeptide binding]; other site 696749006223 NADP binding site [chemical binding]; other site 696749006224 catalytic residues [active] 696749006225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749006226 Helix-turn-helix domains; Region: HTH; cl00088 696749006227 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 696749006228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006229 putative substrate translocation pore; other site 696749006230 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 696749006231 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006232 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749006233 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 696749006234 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 696749006235 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 696749006236 hypothetical protein; Validated; Region: PRK06201 696749006237 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 696749006238 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 696749006239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749006242 putative substrate translocation pore; other site 696749006243 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749006244 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749006245 Protein of unknown function, DUF606; Region: DUF606; cl01273 696749006246 Protein of unknown function, DUF606; Region: DUF606; cl01273 696749006247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749006248 Helix-turn-helix domains; Region: HTH; cl00088 696749006249 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749006250 putative effector binding pocket; other site 696749006251 dimerization interface [polypeptide binding]; other site 696749006252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006253 putative substrate translocation pore; other site 696749006254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749006255 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 696749006256 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 696749006257 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 696749006258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749006259 DNA-binding site [nucleotide binding]; DNA binding site 696749006260 UTRA domain; Region: UTRA; cl01230 696749006261 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 696749006262 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 696749006263 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 696749006264 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 696749006265 active site 696749006266 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 696749006267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006269 potential frameshift: common BLAST hit: gi|184158231|ref|YP_001846570.1| large exoprotein 696749006270 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 696749006271 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 696749006272 MafB19-like deaminase; Region: MafB19-deam; pfam14437 696749006273 haemagglutination activity domain; Region: Haemagg_act; cl05436 696749006274 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 696749006275 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749006276 Surface antigen; Region: Bac_surface_Ag; cl03097 696749006277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749006278 Helix-turn-helix domains; Region: HTH; cl00088 696749006279 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 696749006280 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 696749006281 metal binding site [ion binding]; metal-binding site 696749006282 putative dimer interface [polypeptide binding]; other site 696749006283 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 696749006284 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 696749006285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006286 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 696749006287 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 696749006288 LysR family transcriptional regulator; Provisional; Region: PRK14997 696749006289 Helix-turn-helix domains; Region: HTH; cl00088 696749006290 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 696749006291 putative effector binding pocket; other site 696749006292 putative dimerization interface [polypeptide binding]; other site 696749006293 Isochorismatase family; Region: Isochorismatase; pfam00857 696749006294 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 696749006295 catalytic triad [active] 696749006296 dimer interface [polypeptide binding]; other site 696749006297 conserved cis-peptide bond; other site 696749006298 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 696749006299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749006300 Helix-turn-helix domains; Region: HTH; cl00088 696749006301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749006302 Predicted transcriptional regulator [Transcription]; Region: COG1959 696749006303 Helix-turn-helix domains; Region: HTH; cl00088 696749006304 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 696749006305 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 696749006306 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 696749006307 potential catalytic triad [active] 696749006308 conserved cys residue [active] 696749006309 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696749006310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 696749006311 DNA binding residues [nucleotide binding] 696749006312 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 696749006313 Uncharacterized conserved protein [Function unknown]; Region: COG3268 696749006314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006315 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 696749006316 putative active site [active] 696749006317 putative FMN binding site [chemical binding]; other site 696749006318 putative substrate binding site [chemical binding]; other site 696749006319 putative catalytic residue [active] 696749006320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749006321 Helix-turn-helix domains; Region: HTH; cl00088 696749006322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006323 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 696749006324 substrate binding pocket [chemical binding]; other site 696749006325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006326 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 696749006327 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 696749006328 potential catalytic triad [active] 696749006329 conserved cys residue [active] 696749006330 2-oxoglutarate dehydrogenase E2 component; Region: PLN02226 696749006331 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 696749006332 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 696749006333 tetramer interface [polypeptide binding]; other site 696749006334 heme binding pocket [chemical binding]; other site 696749006335 NADPH binding site [chemical binding]; other site 696749006336 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 696749006337 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006338 HTH-like domain; Region: HTH_21; pfam13276 696749006339 DDE domain; Region: DDE_Tnp_IS240; pfam13610 696749006340 Integrase core domain; Region: rve; cl01316 696749006341 Integrase core domain; Region: rve_3; cl15866 696749006342 Helix-turn-helix domains; Region: HTH; cl00088 696749006343 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 696749006344 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 696749006345 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 696749006346 NAD(P) binding site [chemical binding]; other site 696749006347 catalytic residues [active] 696749006348 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 696749006349 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 696749006350 NAD(P) binding site [chemical binding]; other site 696749006351 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 696749006352 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 696749006353 Na binding site [ion binding]; other site 696749006354 Protein of unknown function, DUF485; Region: DUF485; cl01231 696749006355 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 696749006356 AMP-binding enzyme; Region: AMP-binding; cl15778 696749006357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749006358 Propionate catabolism activator; Region: PrpR_N; pfam06506 696749006359 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 696749006360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749006361 Walker A motif; other site 696749006362 ATP binding site [chemical binding]; other site 696749006363 Walker B motif; other site 696749006364 arginine finger; other site 696749006365 Helix-turn-helix domains; Region: HTH; cl00088 696749006366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749006367 classical (c) SDRs; Region: SDR_c; cd05233 696749006368 NAD(P) binding site [chemical binding]; other site 696749006369 active site 696749006370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749006371 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 696749006372 active site 696749006373 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696749006374 catalytic core [active] 696749006375 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 696749006376 Phosphotransferase enzyme family; Region: APH; pfam01636 696749006377 putative active site [active] 696749006378 putative substrate binding site [chemical binding]; other site 696749006379 ATP binding site [chemical binding]; other site 696749006380 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749006381 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 696749006382 dimer interface [polypeptide binding]; other site 696749006383 NADP binding site [chemical binding]; other site 696749006384 catalytic residues [active] 696749006385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 696749006386 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 696749006387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006388 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 696749006389 putative substrate translocation pore; other site 696749006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006391 Dehydratase family; Region: ILVD_EDD; cl00340 696749006392 Transcriptional regulators [Transcription]; Region: FadR; COG2186 696749006393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749006394 DNA-binding site [nucleotide binding]; DNA binding site 696749006395 FCD domain; Region: FCD; cl11656 696749006396 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 696749006397 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749006398 Helix-turn-helix domains; Region: HTH; cl00088 696749006399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749006400 dimerization interface [polypeptide binding]; other site 696749006401 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 696749006402 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 696749006403 octamer interface [polypeptide binding]; other site 696749006404 active site 696749006405 Muconolactone delta-isomerase; Region: MIase; cl01992 696749006406 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 696749006407 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 696749006408 dimer interface [polypeptide binding]; other site 696749006409 active site 696749006410 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749006411 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749006412 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 696749006413 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749006414 dimer interface [polypeptide binding]; other site 696749006415 active site 696749006416 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 696749006417 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006418 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 696749006419 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 696749006420 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 696749006421 active site 696749006422 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 696749006423 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749006424 NAD(P) binding site [chemical binding]; other site 696749006425 catalytic residues [active] 696749006426 tyramine oxidase; Provisional; Region: tynA; PRK14696 696749006427 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 696749006428 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 696749006429 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 696749006430 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 696749006431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749006432 Flavin Reductases; Region: FlaRed; cl00801 696749006433 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 696749006434 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 696749006435 FMN-binding pocket [chemical binding]; other site 696749006436 flavin binding motif; other site 696749006437 phosphate binding motif [ion binding]; other site 696749006438 beta-alpha-beta structure motif; other site 696749006439 NAD binding pocket [chemical binding]; other site 696749006440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749006441 catalytic loop [active] 696749006442 iron binding site [ion binding]; other site 696749006443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749006444 classical (c) SDRs; Region: SDR_c; cd05233 696749006445 NAD(P) binding site [chemical binding]; other site 696749006446 active site 696749006447 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 696749006448 inter-subunit interface; other site 696749006449 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 696749006450 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 696749006451 [2Fe-2S] cluster binding site [ion binding]; other site 696749006452 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 696749006453 putative alpha subunit interface [polypeptide binding]; other site 696749006454 putative active site [active] 696749006455 putative substrate binding site [chemical binding]; other site 696749006456 Fe binding site [ion binding]; other site 696749006457 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749006458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749006459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749006460 active site 696749006461 Amidase; Region: Amidase; cl11426 696749006462 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 696749006463 Helix-turn-helix domains; Region: HTH; cl00088 696749006464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749006466 putative substrate translocation pore; other site 696749006467 outer membrane porin, OprD family; Region: OprD; pfam03573 696749006468 short chain dehydrogenase; Provisional; Region: PRK08251 696749006469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006470 NAD(P) binding site [chemical binding]; other site 696749006471 active site 696749006472 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 696749006473 catalytic core [active] 696749006474 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 696749006475 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 696749006476 putative active site [active] 696749006477 putative substrate binding site [chemical binding]; other site 696749006478 ATP binding site [chemical binding]; other site 696749006479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749006480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749006481 active site 696749006482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749006483 Helix-turn-helix domains; Region: HTH; cl00088 696749006484 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 696749006485 substrate binding pocket [chemical binding]; other site 696749006486 dimerization interface [polypeptide binding]; other site 696749006487 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 696749006488 Helix-turn-helix domains; Region: HTH; cl00088 696749006489 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749006490 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 696749006491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749006492 Predicted transporter component [General function prediction only]; Region: COG2391 696749006493 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 696749006494 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 696749006495 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 696749006496 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 696749006497 Trp docking motif [polypeptide binding]; other site 696749006498 putative active site [active] 696749006499 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 696749006500 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 696749006501 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 696749006502 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 696749006503 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 696749006504 active site 696749006505 catalytic residue [active] 696749006506 dimer interface [polypeptide binding]; other site 696749006507 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 696749006508 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 696749006509 heterodimer interface [polypeptide binding]; other site 696749006510 active site 696749006511 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 696749006512 heterodimer interface [polypeptide binding]; other site 696749006513 multimer interface [polypeptide binding]; other site 696749006514 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 696749006515 active site 696749006516 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749006517 benzoate transport; Region: 2A0115; TIGR00895 696749006518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006519 putative substrate translocation pore; other site 696749006520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006521 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 696749006522 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 696749006523 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 696749006524 tetramer interface [polypeptide binding]; other site 696749006525 active site 696749006526 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 696749006527 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749006528 dimer interface [polypeptide binding]; other site 696749006529 active site 696749006530 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749006531 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749006532 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 696749006533 substrate binding site; other site 696749006534 dimer interface; other site 696749006535 Septum formation initiator; Region: DivIC; cl11433 696749006536 Protein of unknown function (DUF421); Region: DUF421; cl00990 696749006537 enolase; Provisional; Region: eno; PRK00077 696749006538 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 696749006539 dimer interface [polypeptide binding]; other site 696749006540 metal binding site [ion binding]; metal-binding site 696749006541 substrate binding pocket [chemical binding]; other site 696749006542 NeuB family; Region: NeuB; cl00496 696749006543 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696749006544 CTP synthetase; Validated; Region: pyrG; PRK05380 696749006545 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 696749006546 Catalytic site [active] 696749006547 active site 696749006548 UTP binding site [chemical binding]; other site 696749006549 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 696749006550 active site 696749006551 putative oxyanion hole; other site 696749006552 catalytic triad [active] 696749006553 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749006554 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749006555 hydrolase; Region: PLN02511 696749006556 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 696749006557 active site 696749006558 catalytic triad [active] 696749006559 oxyanion hole [active] 696749006560 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749006561 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 696749006562 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 696749006563 active site 696749006564 FMN binding site [chemical binding]; other site 696749006565 2,4-decadienoyl-CoA binding site; other site 696749006566 catalytic residue [active] 696749006567 4Fe-4S cluster binding site [ion binding]; other site 696749006568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006569 Helix-turn-helix domains; Region: HTH; cl00088 696749006570 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 696749006571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749006572 NeuB family; Region: NeuB; cl00496 696749006573 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696749006574 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 696749006575 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 696749006576 Clp amino terminal domain; Region: Clp_N; pfam02861 696749006577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749006578 Walker A motif; other site 696749006579 ATP binding site [chemical binding]; other site 696749006580 Walker B motif; other site 696749006581 arginine finger; other site 696749006582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749006583 Walker A motif; other site 696749006584 ATP binding site [chemical binding]; other site 696749006585 Walker B motif; other site 696749006586 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 696749006587 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 696749006588 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945 696749006589 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 696749006590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006591 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 696749006592 Protein of unknown function DUF45; Region: DUF45; cl00636 696749006593 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 696749006594 tetramer (dimer of dimers) interface [polypeptide binding]; other site 696749006595 active site 696749006596 dimer interface [polypeptide binding]; other site 696749006597 threonine dehydratase; Reviewed; Region: PRK09224 696749006598 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 696749006599 tetramer interface [polypeptide binding]; other site 696749006600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749006601 catalytic residue [active] 696749006602 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 696749006603 putative Ile/Val binding site [chemical binding]; other site 696749006604 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 696749006605 putative Ile/Val binding site [chemical binding]; other site 696749006606 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 696749006607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006608 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 696749006609 Cation transport protein; Region: TrkH; cl10514 696749006610 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 696749006611 dimerization interface [polypeptide binding]; other site 696749006612 substrate binding site [chemical binding]; other site 696749006613 active site 696749006614 calcium binding site [ion binding]; other site 696749006615 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 696749006616 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 696749006617 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696749006618 Peptidase M16C associated; Region: M16C_assoc; pfam08367 696749006619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696749006620 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749006621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749006622 N-terminal plug; other site 696749006623 ligand-binding site [chemical binding]; other site 696749006624 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 696749006625 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 696749006626 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 696749006627 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 696749006628 substrate binding site [chemical binding]; other site 696749006629 ATP binding site [chemical binding]; other site 696749006630 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 696749006631 iron-sulfur cluster [ion binding]; other site 696749006632 [2Fe-2S] cluster binding site [ion binding]; other site 696749006633 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 696749006634 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749006635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749006636 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 696749006637 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 696749006638 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 696749006639 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 696749006640 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 696749006641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 696749006642 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749006643 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 696749006644 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 696749006645 dimer interface [polypeptide binding]; other site 696749006646 FMN binding site [chemical binding]; other site 696749006647 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 696749006648 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 696749006649 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 696749006650 P loop; other site 696749006651 GTP binding site [chemical binding]; other site 696749006652 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 696749006653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 696749006654 FOG: CBS domain [General function prediction only]; Region: COG0517 696749006655 acetylornithine aminotransferase; Provisional; Region: PRK02627 696749006656 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749006657 inhibitor-cofactor binding pocket; inhibition site 696749006658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749006659 catalytic residue [active] 696749006660 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 696749006661 putative GSH binding site [chemical binding]; other site 696749006662 catalytic residues [active] 696749006663 LysR family transcriptional regulator; Provisional; Region: PRK14997 696749006664 Helix-turn-helix domains; Region: HTH; cl00088 696749006665 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 696749006666 putative effector binding pocket; other site 696749006667 putative dimerization interface [polypeptide binding]; other site 696749006668 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 696749006669 active site 696749006670 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 696749006671 Domain of unknown function (DUF336); Region: DUF336; cl01249 696749006672 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 696749006673 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749006674 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 696749006675 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 696749006676 active site 696749006677 phosphorylation site [posttranslational modification] 696749006678 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 696749006679 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696749006680 dimerization domain swap beta strand [polypeptide binding]; other site 696749006681 regulatory protein interface [polypeptide binding]; other site 696749006682 active site 696749006683 regulatory phosphorylation site [posttranslational modification]; other site 696749006684 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 696749006685 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 696749006686 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 696749006687 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 696749006688 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 696749006689 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 696749006690 putative substrate binding site [chemical binding]; other site 696749006691 putative ATP binding site [chemical binding]; other site 696749006692 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 696749006693 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 696749006694 active site 696749006695 P-loop; other site 696749006696 phosphorylation site [posttranslational modification] 696749006697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 696749006698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 696749006699 Helix-turn-helix domains; Region: HTH; cl00088 696749006700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 696749006701 PAS domain; Region: PAS_9; pfam13426 696749006702 putative active site [active] 696749006703 heme pocket [chemical binding]; other site 696749006704 PAS fold; Region: PAS_4; pfam08448 696749006705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 696749006706 putative active site [active] 696749006707 heme pocket [chemical binding]; other site 696749006708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749006709 metal binding site [ion binding]; metal-binding site 696749006710 active site 696749006711 I-site; other site 696749006712 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 696749006713 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749006714 Ligand Binding Site [chemical binding]; other site 696749006715 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 696749006716 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 696749006717 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 696749006718 Sulfate transporter family; Region: Sulfate_transp; cl15842 696749006719 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 696749006720 Sulfate transporter family; Region: Sulfate_transp; cl15842 696749006721 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 696749006722 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 696749006723 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 696749006724 calcium binding site 2 [ion binding]; other site 696749006725 active site 696749006726 catalytic triad [active] 696749006727 calcium binding site 1 [ion binding]; other site 696749006728 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 696749006729 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 696749006730 kynureninase; Region: kynureninase; TIGR01814 696749006731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749006732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749006733 catalytic residue [active] 696749006734 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 696749006735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749006736 putative DNA binding site [nucleotide binding]; other site 696749006737 putative Zn2+ binding site [ion binding]; other site 696749006738 AsnC family; Region: AsnC_trans_reg; pfam01037 696749006739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 696749006740 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749006741 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 696749006742 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 696749006743 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749006744 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 696749006745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696749006746 RNA binding surface [nucleotide binding]; other site 696749006747 recombinase A; Provisional; Region: recA; PRK09354 696749006748 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 696749006749 hexamer interface [polypeptide binding]; other site 696749006750 Walker A motif; other site 696749006751 ATP binding site [chemical binding]; other site 696749006752 Walker B motif; other site 696749006753 RecX family; Region: RecX; cl00936 696749006754 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 696749006755 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 696749006756 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 696749006757 active site 696749006758 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 696749006759 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 696749006760 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 696749006761 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 696749006762 trimer interface [polypeptide binding]; other site 696749006763 active site 696749006764 UDP-GlcNAc binding site [chemical binding]; other site 696749006765 lipid binding site [chemical binding]; lipid-binding site 696749006766 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 696749006767 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 696749006768 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749006769 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749006770 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749006771 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 696749006772 Surface antigen; Region: Bac_surface_Ag; cl03097 696749006773 zinc metallopeptidase RseP; Provisional; Region: PRK10779 696749006774 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 696749006775 active site 696749006776 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 696749006777 protein binding site [polypeptide binding]; other site 696749006778 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 696749006779 protein binding site [polypeptide binding]; other site 696749006780 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 696749006781 putative substrate binding region [chemical binding]; other site 696749006782 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 696749006783 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 696749006784 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 696749006785 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 696749006786 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 696749006787 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 696749006788 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 696749006789 catalytic residue [active] 696749006790 putative FPP diphosphate binding site; other site 696749006791 putative FPP binding hydrophobic cleft; other site 696749006792 dimer interface [polypeptide binding]; other site 696749006793 putative IPP diphosphate binding site; other site 696749006794 ribosome recycling factor; Reviewed; Region: frr; PRK00083 696749006795 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 696749006796 hinge region; other site 696749006797 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 696749006798 putative nucleotide binding site [chemical binding]; other site 696749006799 uridine monophosphate binding site [chemical binding]; other site 696749006800 homohexameric interface [polypeptide binding]; other site 696749006801 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 696749006802 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 696749006803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749006804 FeS/SAM binding site; other site 696749006805 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 696749006806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 696749006807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749006808 dimer interface [polypeptide binding]; other site 696749006809 phosphorylation site [posttranslational modification] 696749006810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749006811 ATP binding site [chemical binding]; other site 696749006812 Mg2+ binding site [ion binding]; other site 696749006813 G-X-G motif; other site 696749006814 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 696749006815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749006816 active site 696749006817 phosphorylation site [posttranslational modification] 696749006818 intermolecular recognition site; other site 696749006819 dimerization interface [polypeptide binding]; other site 696749006820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749006821 Walker A motif; other site 696749006822 ATP binding site [chemical binding]; other site 696749006823 Walker B motif; other site 696749006824 arginine finger; other site 696749006825 Helix-turn-helix domains; Region: HTH; cl00088 696749006826 potential frameshift: common BLAST hit: gi|215483163|ref|YP_002325370.1| TetR family regulatory protein 696749006827 Helix-turn-helix domains; Region: HTH; cl00088 696749006828 ornithine carbamoyltransferase; Provisional; Region: PRK00779 696749006829 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 696749006830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006831 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 696749006832 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 696749006833 homotrimer interaction site [polypeptide binding]; other site 696749006834 zinc binding site [ion binding]; other site 696749006835 CDP-binding sites; other site 696749006836 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 696749006837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006838 fumarate hydratase; Reviewed; Region: fumC; PRK00485 696749006839 Class II fumarases; Region: Fumarase_classII; cd01362 696749006840 active site 696749006841 tetramer interface [polypeptide binding]; other site 696749006842 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 696749006843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749006844 NAD(P) binding site [chemical binding]; other site 696749006845 active site 696749006846 DsrE/DsrF-like family; Region: DrsE; cl00672 696749006847 DsrC like protein; Region: DsrC; cl01101 696749006848 EamA-like transporter family; Region: EamA; cl01037 696749006849 EamA-like transporter family; Region: EamA; cl01037 696749006850 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749006851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749006852 DNA-binding site [nucleotide binding]; DNA binding site 696749006853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749006854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749006855 homodimer interface [polypeptide binding]; other site 696749006856 catalytic residue [active] 696749006857 Helix-turn-helix domains; Region: HTH; cl00088 696749006858 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 696749006859 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 696749006860 dimer interface [polypeptide binding]; other site 696749006861 putative functional site; other site 696749006862 putative MPT binding site; other site 696749006863 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 696749006864 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 696749006865 trimer interface [polypeptide binding]; other site 696749006866 dimer interface [polypeptide binding]; other site 696749006867 putative active site [active] 696749006868 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 696749006869 MPT binding site; other site 696749006870 trimer interface [polypeptide binding]; other site 696749006871 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 696749006872 MoaE homodimer interface [polypeptide binding]; other site 696749006873 MoaD interaction [polypeptide binding]; other site 696749006874 active site residues [active] 696749006875 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 696749006876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749006877 FeS/SAM binding site; other site 696749006878 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 696749006879 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 696749006880 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 696749006881 molybdopterin cofactor binding site; other site 696749006882 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 696749006883 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 696749006884 putative molybdopterin cofactor binding site; other site 696749006885 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 696749006886 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 696749006887 GTP binding site; other site 696749006888 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 696749006889 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 696749006890 [4Fe-4S] binding site [ion binding]; other site 696749006891 molybdopterin cofactor binding site; other site 696749006892 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 696749006893 molybdopterin cofactor binding site; other site 696749006894 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 696749006895 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 696749006896 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 696749006897 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 696749006898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749006899 nitrite reductase subunit NirD; Provisional; Region: PRK14989 696749006900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749006901 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 696749006902 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 696749006903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749006904 active site 696749006905 phosphorylation site [posttranslational modification] 696749006906 intermolecular recognition site; other site 696749006907 dimerization interface [polypeptide binding]; other site 696749006908 ANTAR domain; Region: ANTAR; cl04297 696749006909 NMT1-like family; Region: NMT1_2; cl15260 696749006910 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 696749006911 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 696749006912 active site 696749006913 DNA binding site [nucleotide binding] 696749006914 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 696749006915 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 696749006916 trimer interface [polypeptide binding]; other site 696749006917 active site 696749006918 dimer interface [polypeptide binding]; other site 696749006919 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 696749006920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696749006921 carboxyltransferase (CT) interaction site; other site 696749006922 biotinylation site [posttranslational modification]; other site 696749006923 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 696749006924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749006925 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749006926 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 696749006927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749006928 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 696749006929 putative substrate translocation pore; other site 696749006930 putative metal dependent hydrolase; Provisional; Region: PRK11598 696749006931 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 696749006932 Sulfatase; Region: Sulfatase; cl10460 696749006933 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 696749006934 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 696749006935 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 696749006936 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 696749006937 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 696749006938 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 696749006939 BRO family, N-terminal domain; Region: Bro-N; cl10591 696749006940 Arc-like DNA binding domain; Region: Arc; pfam03869 696749006941 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 696749006942 tape measure domain; Region: tape_meas_nterm; TIGR02675 696749006943 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 696749006944 internal virion protein D; Region: PHA00368 696749006945 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749006946 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749006947 catalytic residue [active] 696749006948 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 696749006949 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 696749006950 YcfA-like protein; Region: YcfA; cl00752 696749006951 Putative stress-responsive nuclear envelope protein; Region: Ish1; pfam10281 696749006952 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 696749006953 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 696749006954 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 696749006955 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 696749006956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 696749006957 Terminase-like family; Region: Terminase_6; pfam03237 696749006958 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 696749006959 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 696749006960 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 696749006961 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 696749006962 putative active site [active] 696749006963 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 696749006964 Predicted transcriptional regulator [Transcription]; Region: COG2932 696749006965 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696749006966 Catalytic site [active] 696749006967 AAA domain; Region: AAA_24; pfam13479 696749006968 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 696749006969 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 696749006970 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 696749006971 glutamine binding [chemical binding]; other site 696749006972 catalytic triad [active] 696749006973 Peptidase family M1; Region: Peptidase_M1; pfam01433 696749006974 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 696749006975 Zn binding site [ion binding]; other site 696749006976 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 696749006977 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696749006978 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749006979 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749006980 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 696749006981 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 696749006982 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 696749006983 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 696749006984 active site 696749006985 ribulose/triose binding site [chemical binding]; other site 696749006986 phosphate binding site [ion binding]; other site 696749006987 substrate (anthranilate) binding pocket [chemical binding]; other site 696749006988 product (indole) binding pocket [chemical binding]; other site 696749006989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 696749006990 Smr domain; Region: Smr; cl02619 696749006991 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 696749006992 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 696749006993 XdhC Rossmann domain; Region: XdhC_C; pfam13478 696749006994 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 696749006995 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 696749006996 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 696749006997 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 696749006998 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 696749006999 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 696749007000 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 696749007001 homodecamer interface [polypeptide binding]; other site 696749007002 GTP cyclohydrolase I; Provisional; Region: PLN03044 696749007003 active site 696749007004 putative catalytic site residues [active] 696749007005 zinc binding site [ion binding]; other site 696749007006 GTP-CH-I/GFRP interaction surface; other site 696749007007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007008 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 696749007009 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749007010 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 696749007011 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 696749007012 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 696749007013 Protein of unknown function (DUF817); Region: DUF817; cl01520 696749007014 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 696749007015 substrate binding site [chemical binding]; other site 696749007016 active site 696749007017 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 696749007018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 696749007019 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 696749007020 chorismate binding enzyme; Region: Chorismate_bind; cl10555 696749007021 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 696749007022 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 696749007023 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 696749007024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 696749007025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749007026 Walker A/P-loop; other site 696749007027 ATP binding site [chemical binding]; other site 696749007028 Q-loop/lid; other site 696749007029 ABC transporter signature motif; other site 696749007030 Walker B; other site 696749007031 D-loop; other site 696749007032 H-loop/switch region; other site 696749007033 potential frameshift: common BLAST hit: gi|184158894|ref|YP_001847233.1| multidrug ABC transporter ATPase and permease 696749007034 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 696749007035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749007036 Walker A/P-loop; other site 696749007037 ATP binding site [chemical binding]; other site 696749007038 Q-loop/lid; other site 696749007039 ABC transporter signature motif; other site 696749007040 Walker B; other site 696749007041 D-loop; other site 696749007042 H-loop/switch region; other site 696749007043 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 696749007044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749007045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749007046 catalytic residue [active] 696749007047 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 696749007048 hydrophobic substrate binding pocket; other site 696749007049 Isochorismatase family; Region: Isochorismatase; pfam00857 696749007050 active site 696749007051 conserved cis-peptide bond; other site 696749007052 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749007053 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 696749007054 AMP-binding enzyme; Region: AMP-binding; cl15778 696749007055 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749007056 Condensation domain; Region: Condensation; pfam00668 696749007057 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 696749007058 Nonribosomal peptide synthase; Region: NRPS; pfam08415 696749007059 Condensation domain; Region: Condensation; pfam00668 696749007060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 696749007061 Nonribosomal peptide synthase; Region: NRPS; pfam08415 696749007062 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749007063 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 696749007064 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749007065 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749007066 N-terminal plug; other site 696749007067 ligand-binding site [chemical binding]; other site 696749007068 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 696749007069 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 696749007070 putative ligand binding residues [chemical binding]; other site 696749007071 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696749007072 Walker A/P-loop; other site 696749007073 ATP binding site [chemical binding]; other site 696749007074 ABC transporter; Region: ABC_tran; pfam00005 696749007075 Q-loop/lid; other site 696749007076 ABC transporter signature motif; other site 696749007077 Walker B; other site 696749007078 D-loop; other site 696749007079 H-loop/switch region; other site 696749007080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696749007081 ABC-ATPase subunit interface; other site 696749007082 dimer interface [polypeptide binding]; other site 696749007083 putative PBP binding regions; other site 696749007084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696749007085 ABC-ATPase subunit interface; other site 696749007086 dimer interface [polypeptide binding]; other site 696749007087 putative PBP binding regions; other site 696749007088 peptide synthase; Validated; Region: PRK05691 696749007089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749007090 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 696749007091 AMP-binding enzyme; Region: AMP-binding; cl15778 696749007092 AMP-binding enzyme; Region: AMP-binding; cl15778 696749007093 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 696749007094 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 696749007095 FAD binding pocket [chemical binding]; other site 696749007096 FAD binding motif [chemical binding]; other site 696749007097 phosphate binding motif [ion binding]; other site 696749007098 NAD binding pocket [chemical binding]; other site 696749007099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 696749007100 YheO-like PAS domain; Region: PAS_6; pfam08348 696749007101 Helix-turn-helix domains; Region: HTH; cl00088 696749007102 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 696749007103 catalytic residue [active] 696749007104 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 696749007105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749007106 Pirin-related protein [General function prediction only]; Region: COG1741 696749007107 Cupin domain; Region: Cupin_2; cl09118 696749007108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007109 Helix-turn-helix domains; Region: HTH; cl00088 696749007110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007111 Helix-turn-helix domains; Region: HTH; cl00088 696749007112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007113 Helix-turn-helix domains; Region: HTH; cl00088 696749007114 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 696749007115 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 696749007116 putative NAD(P) binding site [chemical binding]; other site 696749007117 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 696749007118 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 696749007119 active site pocket [active] 696749007120 potential frameshift: common BLAST hit: gi|184158920|ref|YP_001847259.1| major facilitator superfamily permease 696749007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749007122 putative substrate translocation pore; other site 696749007123 cation transport protein; Region: 2A0119; TIGR00898 696749007124 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 696749007125 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 696749007126 EamA-like transporter family; Region: EamA; cl01037 696749007127 EamA-like transporter family; Region: EamA; cl01037 696749007128 aromatic amino acid exporter; Provisional; Region: PRK11689 696749007129 MarC family integral membrane protein; Region: MarC; cl00919 696749007130 Cupin domain; Region: Cupin_2; cl09118 696749007131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007132 FAD dependent oxidoreductase; Region: DAO; pfam01266 696749007133 Rubredoxin [Energy production and conversion]; Region: COG1773 696749007134 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 696749007135 iron binding site [ion binding]; other site 696749007136 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 696749007137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749007138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007139 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749007140 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 696749007141 NAD(P) binding site [chemical binding]; other site 696749007142 catalytic residues [active] 696749007143 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 696749007144 iron-sulfur cluster [ion binding]; other site 696749007145 [2Fe-2S] cluster binding site [ion binding]; other site 696749007146 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 696749007147 alpha subunit interface [polypeptide binding]; other site 696749007148 active site 696749007149 substrate binding site [chemical binding]; other site 696749007150 Fe binding site [ion binding]; other site 696749007151 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007152 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 696749007153 BCCT family transporter; Region: BCCT; cl00569 696749007154 BCCT family transporter; Region: BCCT; cl00569 696749007155 potential frameshift: common BLAST hit: gi|184158933|ref|YP_001847272.1| transcriptional regulator 696749007156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749007157 Helix-turn-helix domains; Region: HTH; cl00088 696749007158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749007159 dimerization interface [polypeptide binding]; other site 696749007160 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 696749007161 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 696749007162 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749007163 tetrameric interface [polypeptide binding]; other site 696749007164 NAD binding site [chemical binding]; other site 696749007165 catalytic residues [active] 696749007166 Cupin domain; Region: Cupin_2; cl09118 696749007167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007168 FAD dependent oxidoreductase; Region: DAO; pfam01266 696749007169 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 696749007170 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 696749007171 Helix-turn-helix domains; Region: HTH; cl00088 696749007172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007173 Helix-turn-helix domains; Region: HTH; cl00088 696749007174 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 696749007175 Protein of unknown function (DUF466); Region: DUF466; cl01082 696749007176 carbon starvation protein A; Provisional; Region: PRK15015 696749007177 Carbon starvation protein CstA; Region: CstA; pfam02554 696749007178 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 696749007179 elongation factor P; Validated; Region: PRK00529 696749007180 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 696749007181 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 696749007182 RNA binding site [nucleotide binding]; other site 696749007183 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 696749007184 RNA binding site [nucleotide binding]; other site 696749007185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 696749007186 Radical SAM superfamily; Region: Radical_SAM; pfam04055 696749007187 PAS domain S-box; Region: sensory_box; TIGR00229 696749007188 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 696749007189 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 696749007190 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 696749007191 Membrane transport protein; Region: Mem_trans; cl09117 696749007192 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 696749007193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696749007194 dimer interface [polypeptide binding]; other site 696749007195 active site 696749007196 glutathione binding site [chemical binding]; other site 696749007197 metal binding site [ion binding]; metal-binding site 696749007198 muropeptide transporter; Validated; Region: ampG; PRK11010 696749007199 AmpG-like permease; Region: 2A0125; TIGR00901 696749007200 muropeptide transporter; Validated; Region: ampG; PRK11010 696749007201 AAA domain; Region: AAA_32; pfam13654 696749007202 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 696749007203 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 696749007204 transcriptional regulator; Provisional; Region: PRK10632 696749007205 Helix-turn-helix domains; Region: HTH; cl00088 696749007206 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749007207 putative effector binding pocket; other site 696749007208 dimerization interface [polypeptide binding]; other site 696749007209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749007210 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 696749007211 Survival protein SurE; Region: SurE; cl00448 696749007212 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 696749007213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749007214 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 696749007215 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 696749007216 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 696749007217 trimer interface [polypeptide binding]; other site 696749007218 putative metal binding site [ion binding]; other site 696749007219 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 696749007220 nudix motif; other site 696749007221 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 696749007222 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 696749007223 Protein of unknown function (DUF489); Region: DUF489; cl01097 696749007224 adenylosuccinate lyase; Provisional; Region: PRK09285 696749007225 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 696749007226 tetramer interface [polypeptide binding]; other site 696749007227 active site 696749007228 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 696749007229 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007230 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 696749007231 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 696749007232 tandem repeat interface [polypeptide binding]; other site 696749007233 oligomer interface [polypeptide binding]; other site 696749007234 active site residues [active] 696749007235 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 696749007236 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 696749007237 Walker A/P-loop; other site 696749007238 ATP binding site [chemical binding]; other site 696749007239 Q-loop/lid; other site 696749007240 ABC transporter signature motif; other site 696749007241 Walker B; other site 696749007242 D-loop; other site 696749007243 H-loop/switch region; other site 696749007244 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 696749007245 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 696749007246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749007247 dimer interface [polypeptide binding]; other site 696749007248 conserved gate region; other site 696749007249 putative PBP binding loops; other site 696749007250 ABC-ATPase subunit interface; other site 696749007251 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 696749007252 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 696749007253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749007254 dimer interface [polypeptide binding]; other site 696749007255 conserved gate region; other site 696749007256 putative PBP binding loops; other site 696749007257 ABC-ATPase subunit interface; other site 696749007258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749007259 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749007260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007261 aromatic amino acid transporter; Provisional; Region: PRK10238 696749007262 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 696749007263 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 696749007264 dimer interface [polypeptide binding]; other site 696749007265 PYR/PP interface [polypeptide binding]; other site 696749007266 TPP binding site [chemical binding]; other site 696749007267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 696749007268 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 696749007269 TPP-binding site [chemical binding]; other site 696749007270 dimer interface [polypeptide binding]; other site 696749007271 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 696749007272 Helix-turn-helix domains; Region: HTH; cl00088 696749007273 AsnC family; Region: AsnC_trans_reg; pfam01037 696749007274 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749007275 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 696749007276 NAD(P) binding site [chemical binding]; other site 696749007277 catalytic residues [active] 696749007278 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 696749007279 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 696749007280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007281 catalytic residue [active] 696749007282 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 696749007283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749007284 inhibitor-cofactor binding pocket; inhibition site 696749007285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007286 catalytic residue [active] 696749007287 Protein of unknown function (DUF541); Region: SIMPL; cl01077 696749007288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007289 Helix-turn-helix domains; Region: HTH; cl00088 696749007290 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749007291 CoenzymeA binding site [chemical binding]; other site 696749007292 subunit interaction site [polypeptide binding]; other site 696749007293 PHB binding site; other site 696749007294 Fatty acid desaturase; Region: FA_desaturase; pfam00487 696749007295 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 696749007296 putative di-iron ligands [ion binding]; other site 696749007297 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 696749007298 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 696749007299 FAD binding pocket [chemical binding]; other site 696749007300 FAD binding motif [chemical binding]; other site 696749007301 phosphate binding motif [ion binding]; other site 696749007302 beta-alpha-beta structure motif; other site 696749007303 NAD binding pocket [chemical binding]; other site 696749007304 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696749007305 catalytic loop [active] 696749007306 iron binding site [ion binding]; other site 696749007307 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 696749007308 Helix-turn-helix domains; Region: HTH; cl00088 696749007309 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 696749007310 ATP-dependent helicase HepA; Validated; Region: PRK04914 696749007311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749007312 ATP binding site [chemical binding]; other site 696749007313 putative Mg++ binding site [ion binding]; other site 696749007314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749007315 nucleotide binding region [chemical binding]; other site 696749007316 ATP-binding site [chemical binding]; other site 696749007317 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696749007318 active site 696749007319 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749007320 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 696749007321 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749007322 inhibitor-cofactor binding pocket; inhibition site 696749007323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007324 catalytic residue [active] 696749007325 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 696749007326 thiamine phosphate binding site [chemical binding]; other site 696749007327 active site 696749007328 pyrophosphate binding site [ion binding]; other site 696749007329 Protein of unknown function (DUF962); Region: DUF962; cl01879 696749007330 Uncharacterized conserved protein [Function unknown]; Region: COG3025 696749007331 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 696749007332 putative active site [active] 696749007333 putative metal binding residues [ion binding]; other site 696749007334 signature motif; other site 696749007335 putative triphosphate binding site [ion binding]; other site 696749007336 CHAD domain; Region: CHAD; cl10506 696749007337 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 696749007338 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 696749007339 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 696749007340 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696749007341 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 696749007342 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696749007343 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 696749007344 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749007345 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696749007346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749007347 Helix-turn-helix domains; Region: HTH; cl00088 696749007348 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 696749007349 putative dimerization interface [polypeptide binding]; other site 696749007350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749007351 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 696749007352 isocitrate dehydrogenase; Validated; Region: PRK06451 696749007353 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 696749007354 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 696749007355 pseudouridine synthase; Region: TIGR00093 696749007356 active site 696749007357 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 696749007358 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 696749007359 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 696749007360 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 696749007361 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 696749007362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749007363 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 696749007364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749007365 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 696749007366 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 696749007367 DNA photolyase; Region: DNA_photolyase; pfam00875 696749007368 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 696749007369 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 696749007370 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 696749007371 DXD motif; other site 696749007372 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 696749007373 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 696749007374 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 696749007375 active site 696749007376 homodimer interface [polypeptide binding]; other site 696749007377 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 696749007378 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 696749007379 Nitronate monooxygenase; Region: NMO; pfam03060 696749007380 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 696749007381 FMN binding site [chemical binding]; other site 696749007382 substrate binding site [chemical binding]; other site 696749007383 putative catalytic residue [active] 696749007384 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 696749007385 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696749007386 FMN binding site [chemical binding]; other site 696749007387 active site 696749007388 catalytic residues [active] 696749007389 substrate binding site [chemical binding]; other site 696749007390 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 696749007391 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749007392 gamma-glutamyl kinase; Provisional; Region: PRK05429 696749007393 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 696749007394 nucleotide binding site [chemical binding]; other site 696749007395 homotetrameric interface [polypeptide binding]; other site 696749007396 putative phosphate binding site [ion binding]; other site 696749007397 putative allosteric binding site; other site 696749007398 PUA domain; Region: PUA; cl00607 696749007399 GTPase CgtA; Reviewed; Region: obgE; PRK12298 696749007400 GTP1/OBG; Region: GTP1_OBG; pfam01018 696749007401 Obg GTPase; Region: Obg; cd01898 696749007402 G1 box; other site 696749007403 GTP/Mg2+ binding site [chemical binding]; other site 696749007404 Switch I region; other site 696749007405 G2 box; other site 696749007406 G3 box; other site 696749007407 Switch II region; other site 696749007408 G4 box; other site 696749007409 G5 box; other site 696749007410 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749007411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007412 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 696749007413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007414 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 696749007415 Predicted permeases [General function prediction only]; Region: RarD; COG2962 696749007416 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 696749007417 excinuclease ABC subunit B; Provisional; Region: PRK05298 696749007418 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 696749007419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749007420 ATP-binding site [chemical binding]; other site 696749007421 ATP binding site [chemical binding]; other site 696749007422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749007423 nucleotide binding region [chemical binding]; other site 696749007424 ATP-binding site [chemical binding]; other site 696749007425 Ultra-violet resistance protein B; Region: UvrB; pfam12344 696749007426 UvrB/uvrC motif; Region: UVR; pfam02151 696749007427 hypothetical protein; Region: PHA00684 696749007428 PAS domain; Region: PAS_9; pfam13426 696749007429 PAS domain; Region: PAS_9; pfam13426 696749007430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749007431 metal binding site [ion binding]; metal-binding site 696749007432 active site 696749007433 I-site; other site 696749007434 aspartate aminotransferase; Provisional; Region: PRK05764 696749007435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749007436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007437 homodimer interface [polypeptide binding]; other site 696749007438 catalytic residue [active] 696749007439 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 696749007440 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749007441 CoenzymeA binding site [chemical binding]; other site 696749007442 subunit interaction site [polypeptide binding]; other site 696749007443 PHB binding site; other site 696749007444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007445 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 696749007446 NAD(P) binding site [chemical binding]; other site 696749007447 active site 696749007448 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 696749007449 active site 696749007450 dinuclear metal binding site [ion binding]; other site 696749007451 dimerization interface [polypeptide binding]; other site 696749007452 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 696749007453 active site 696749007454 hydrophilic channel; other site 696749007455 dimerization interface [polypeptide binding]; other site 696749007456 catalytic residues [active] 696749007457 active site lid [active] 696749007458 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 696749007459 Recombination protein O N terminal; Region: RecO_N; cl15812 696749007460 Recombination protein O C terminal; Region: RecO_C; pfam02565 696749007461 GTPase Era; Reviewed; Region: era; PRK00089 696749007462 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 696749007463 G1 box; other site 696749007464 GTP/Mg2+ binding site [chemical binding]; other site 696749007465 Switch I region; other site 696749007466 G2 box; other site 696749007467 Switch II region; other site 696749007468 G3 box; other site 696749007469 G4 box; other site 696749007470 G5 box; other site 696749007471 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 696749007472 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 696749007473 metal binding site [ion binding]; metal-binding site 696749007474 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 696749007475 dsRNA binding site [nucleotide binding]; other site 696749007476 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 696749007477 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 696749007478 Catalytic site [active] 696749007479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 696749007480 GTP-binding protein LepA; Provisional; Region: PRK05433 696749007481 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 696749007482 G1 box; other site 696749007483 putative GEF interaction site [polypeptide binding]; other site 696749007484 GTP/Mg2+ binding site [chemical binding]; other site 696749007485 Switch I region; other site 696749007486 G2 box; other site 696749007487 G3 box; other site 696749007488 Switch II region; other site 696749007489 G4 box; other site 696749007490 G5 box; other site 696749007491 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 696749007492 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 696749007493 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 696749007494 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696749007495 active site 696749007496 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 696749007497 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 696749007498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696749007499 protein binding site [polypeptide binding]; other site 696749007500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696749007501 protein binding site [polypeptide binding]; other site 696749007502 L-aspartate oxidase; Provisional; Region: PRK09077 696749007503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007504 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 696749007505 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749007506 CoenzymeA binding site [chemical binding]; other site 696749007507 subunit interaction site [polypeptide binding]; other site 696749007508 PHB binding site; other site 696749007509 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 696749007510 thymidylate kinase; Validated; Region: tmk; PRK00698 696749007511 TMP-binding site; other site 696749007512 ATP-binding site [chemical binding]; other site 696749007513 YceG-like family; Region: YceG; pfam02618 696749007514 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 696749007515 dimerization interface [polypeptide binding]; other site 696749007516 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 696749007517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007518 catalytic residue [active] 696749007519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749007520 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 696749007521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749007522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749007523 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 696749007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749007525 dimer interface [polypeptide binding]; other site 696749007526 conserved gate region; other site 696749007527 putative PBP binding loops; other site 696749007528 ABC-ATPase subunit interface; other site 696749007529 sulfate transport protein; Provisional; Region: cysT; CHL00187 696749007530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696749007531 dimer interface [polypeptide binding]; other site 696749007532 conserved gate region; other site 696749007533 putative PBP binding loops; other site 696749007534 ABC-ATPase subunit interface; other site 696749007535 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 696749007536 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 696749007537 Walker A/P-loop; other site 696749007538 ATP binding site [chemical binding]; other site 696749007539 Q-loop/lid; other site 696749007540 ABC transporter signature motif; other site 696749007541 Walker B; other site 696749007542 D-loop; other site 696749007543 H-loop/switch region; other site 696749007544 TOBE-like domain; Region: TOBE_3; pfam12857 696749007545 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 696749007546 Helix-turn-helix domains; Region: HTH; cl00088 696749007547 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 696749007548 substrate binding site [chemical binding]; other site 696749007549 dimerization interface [polypeptide binding]; other site 696749007550 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 696749007551 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 696749007552 active site 696749007553 substrate binding site [chemical binding]; other site 696749007554 trimer interface [polypeptide binding]; other site 696749007555 CoA binding site [chemical binding]; other site 696749007556 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 696749007557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749007558 FeS/SAM binding site; other site 696749007559 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 696749007560 Ligand Binding Site [chemical binding]; other site 696749007561 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 696749007562 Ligand Binding Site [chemical binding]; other site 696749007563 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 696749007564 catalytic triad [active] 696749007565 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 696749007566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696749007567 active site 696749007568 nucleotide binding site [chemical binding]; other site 696749007569 HIGH motif; other site 696749007570 KMSKS motif; other site 696749007571 enoyl-CoA hydratase; Provisional; Region: PRK06688 696749007572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749007573 substrate binding site [chemical binding]; other site 696749007574 oxyanion hole (OAH) forming residues; other site 696749007575 trimer interface [polypeptide binding]; other site 696749007576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 696749007577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749007578 putative substrate translocation pore; other site 696749007579 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 696749007580 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 696749007581 dimerization interface [polypeptide binding]; other site 696749007582 ATP binding site [chemical binding]; other site 696749007583 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 696749007584 dimerization interface [polypeptide binding]; other site 696749007585 ATP binding site [chemical binding]; other site 696749007586 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 696749007587 putative active site [active] 696749007588 catalytic triad [active] 696749007589 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 696749007590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749007591 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 696749007592 RuvA N terminal domain; Region: RuvA_N; pfam01330 696749007593 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 696749007594 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 696749007595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749007596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749007597 Walker A motif; other site 696749007598 ATP binding site [chemical binding]; other site 696749007599 Walker B motif; other site 696749007600 arginine finger; other site 696749007601 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 696749007602 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 696749007603 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 696749007604 metal binding site [ion binding]; metal-binding site 696749007605 putative dimer interface [polypeptide binding]; other site 696749007606 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696749007607 active site 696749007608 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 696749007609 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696749007610 translocation protein TolB; Provisional; Region: tolB; PRK04922 696749007611 TolB amino-terminal domain; Region: TolB_N; cl00639 696749007612 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 696749007613 structural tetrad; other site 696749007614 putative outer membrane lipoprotein; Provisional; Region: PRK09967 696749007615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749007616 ligand binding site [chemical binding]; other site 696749007617 fructose-1,6-bisphosphatase family protein; Region: PLN02628 696749007618 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 696749007619 AMP binding site [chemical binding]; other site 696749007620 metal binding site [ion binding]; metal-binding site 696749007621 active site 696749007622 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 696749007623 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 696749007624 RNA polymerase factor sigma-70; Validated; Region: PRK09047 696749007625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696749007626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696749007627 DNA binding residues [nucleotide binding] 696749007628 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 696749007629 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 696749007630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007631 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 696749007632 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 696749007633 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 696749007634 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749007635 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 696749007636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 696749007637 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 696749007638 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 696749007639 dimerization interface [polypeptide binding]; other site 696749007640 putative ATP binding site [chemical binding]; other site 696749007641 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 696749007642 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 696749007643 active site 696749007644 substrate binding site [chemical binding]; other site 696749007645 cosubstrate binding site; other site 696749007646 catalytic site [active] 696749007647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749007648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749007649 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 696749007650 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 696749007651 tandem repeat interface [polypeptide binding]; other site 696749007652 oligomer interface [polypeptide binding]; other site 696749007653 active site residues [active] 696749007654 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 696749007655 Competence protein; Region: Competence; cl00471 696749007656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749007657 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 696749007658 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 696749007659 Walker A/P-loop; other site 696749007660 ATP binding site [chemical binding]; other site 696749007661 Q-loop/lid; other site 696749007662 ABC transporter signature motif; other site 696749007663 Walker B; other site 696749007664 D-loop; other site 696749007665 H-loop/switch region; other site 696749007666 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 696749007667 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696749007668 FtsX-like permease family; Region: FtsX; cl15850 696749007669 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 696749007670 EamA-like transporter family; Region: EamA; cl01037 696749007671 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 696749007672 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 696749007673 homodimer interface [polypeptide binding]; other site 696749007674 substrate-cofactor binding pocket; other site 696749007675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749007676 catalytic residue [active] 696749007677 Outer membrane efflux protein; Region: OEP; pfam02321 696749007678 Outer membrane efflux protein; Region: OEP; pfam02321 696749007679 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 696749007680 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749007681 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749007682 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 696749007683 ABC-2 type transporter; Region: ABC2_membrane; cl11417 696749007684 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 696749007685 putative homodimer interface [polypeptide binding]; other site 696749007686 putative active site [active] 696749007687 YdjC motif; other site 696749007688 Mg binding site [ion binding]; other site 696749007689 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 696749007690 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 696749007691 Ligand binding site; other site 696749007692 Putative Catalytic site; other site 696749007693 DXD motif; other site 696749007694 GtrA-like protein; Region: GtrA; cl00971 696749007695 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 696749007696 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 696749007697 DNA gyrase subunit A; Validated; Region: PRK05560 696749007698 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 696749007699 CAP-like domain; other site 696749007700 active site 696749007701 primary dimer interface [polypeptide binding]; other site 696749007702 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007703 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007704 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007707 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696749007708 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 696749007709 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 696749007710 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 696749007711 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 696749007712 Ligand binding site [chemical binding]; other site 696749007713 Electron transfer flavoprotein domain; Region: ETF; pfam01012 696749007714 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 696749007715 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696749007716 active site 696749007717 DNA binding site [nucleotide binding] 696749007718 Int/Topo IB signature motif; other site 696749007719 LysE type translocator; Region: LysE; cl00565 696749007720 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 696749007721 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 696749007722 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 696749007723 diaminopimelate decarboxylase; Region: lysA; TIGR01048 696749007724 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 696749007725 active site 696749007726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696749007727 substrate binding site [chemical binding]; other site 696749007728 catalytic residues [active] 696749007729 dimer interface [polypeptide binding]; other site 696749007730 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 696749007731 DNA repair protein RadA; Provisional; Region: PRK11823 696749007732 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 696749007733 Walker A motif/ATP binding site; other site 696749007734 ATP binding site [chemical binding]; other site 696749007735 Walker B motif; other site 696749007736 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 696749007737 Tim44-like domain; Region: Tim44; cl09208 696749007738 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 696749007739 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 696749007740 motif 1; other site 696749007741 dimer interface [polypeptide binding]; other site 696749007742 active site 696749007743 motif 2; other site 696749007744 motif 3; other site 696749007745 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 696749007746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007747 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 696749007748 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 696749007749 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 696749007750 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 696749007751 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 696749007752 putative molybdopterin cofactor binding site [chemical binding]; other site 696749007753 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 696749007754 putative molybdopterin cofactor binding site; other site 696749007755 potential frameshift: common BLAST hit: gi|184159206|ref|YP_001847545.1| glycerate kinase 696749007756 Glycerate kinase family; Region: Gly_kinase; cl00841 696749007757 Glycerate kinase family; Region: Gly_kinase; cl00841 696749007758 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 696749007759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007760 NAD(P) binding site [chemical binding]; other site 696749007761 active site 696749007762 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 696749007763 dimer interface [polypeptide binding]; other site 696749007764 FMN binding site [chemical binding]; other site 696749007765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007766 Helix-turn-helix domains; Region: HTH; cl00088 696749007767 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749007768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749007769 Helix-turn-helix domains; Region: HTH; cl00088 696749007770 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 696749007771 AMP-binding enzyme; Region: AMP-binding; cl15778 696749007772 AMP-binding enzyme; Region: AMP-binding; cl15778 696749007773 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696749007774 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 696749007775 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 696749007776 putative trimer interface [polypeptide binding]; other site 696749007777 putative CoA binding site [chemical binding]; other site 696749007778 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 696749007779 putative CoA binding site [chemical binding]; other site 696749007780 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 696749007781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749007782 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 696749007783 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 696749007784 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 696749007785 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 696749007786 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 696749007787 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749007788 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749007789 catalytic residue [active] 696749007790 SCP-2 sterol transfer family; Region: SCP2; cl01225 696749007791 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 696749007792 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 696749007793 Ligand Binding Site [chemical binding]; other site 696749007794 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749007795 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749007796 catalytic residue [active] 696749007797 Peptidase family M48; Region: Peptidase_M48; cl12018 696749007798 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 696749007799 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 696749007800 Protein export membrane protein; Region: SecD_SecF; cl14618 696749007801 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 696749007802 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 696749007803 putative active site [active] 696749007804 catalytic site [active] 696749007805 putative metal binding site [ion binding]; other site 696749007806 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749007807 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 696749007808 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 696749007809 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 696749007810 ring oligomerisation interface [polypeptide binding]; other site 696749007811 ATP/Mg binding site [chemical binding]; other site 696749007812 stacking interactions; other site 696749007813 hinge regions; other site 696749007814 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 696749007815 oligomerisation interface [polypeptide binding]; other site 696749007816 mobile loop; other site 696749007817 roof hairpin; other site 696749007818 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007819 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 696749007820 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007821 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007822 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 696749007823 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007824 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007825 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 696749007826 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 696749007827 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696749007828 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 696749007829 putative active site [active] 696749007830 putative metal binding site [ion binding]; other site 696749007831 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 696749007832 active site 696749007833 metal binding site [ion binding]; metal-binding site 696749007834 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 696749007835 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 696749007836 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 696749007837 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 696749007838 active site 696749007839 substrate-binding site [chemical binding]; other site 696749007840 metal-binding site [ion binding] 696749007841 GTP binding site [chemical binding]; other site 696749007842 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 696749007843 glycerol kinase; Provisional; Region: glpK; PRK00047 696749007844 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 696749007845 N- and C-terminal domain interface [polypeptide binding]; other site 696749007846 active site 696749007847 MgATP binding site [chemical binding]; other site 696749007848 catalytic site [active] 696749007849 metal binding site [ion binding]; metal-binding site 696749007850 glycerol binding site [chemical binding]; other site 696749007851 homotetramer interface [polypeptide binding]; other site 696749007852 homodimer interface [polypeptide binding]; other site 696749007853 FBP binding site [chemical binding]; other site 696749007854 protein IIAGlc interface [polypeptide binding]; other site 696749007855 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 696749007856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749007857 putative substrate translocation pore; other site 696749007858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749007859 S-adenosylmethionine binding site [chemical binding]; other site 696749007860 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 696749007861 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 696749007862 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 696749007863 homodimer interface [polypeptide binding]; other site 696749007864 NADP binding site [chemical binding]; other site 696749007865 substrate binding site [chemical binding]; other site 696749007866 PhoD-like phosphatase; Region: PhoD; pfam09423 696749007867 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 696749007868 putative active site [active] 696749007869 putative metal binding site [ion binding]; other site 696749007870 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 696749007871 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 696749007872 dihydropteroate synthase; Region: DHPS; TIGR01496 696749007873 substrate binding pocket [chemical binding]; other site 696749007874 dimer interface [polypeptide binding]; other site 696749007875 inhibitor binding site; inhibition site 696749007876 FtsH Extracellular; Region: FtsH_ext; pfam06480 696749007877 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 696749007878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749007879 Walker A motif; other site 696749007880 ATP binding site [chemical binding]; other site 696749007881 Walker B motif; other site 696749007882 arginine finger; other site 696749007883 Peptidase family M41; Region: Peptidase_M41; pfam01434 696749007884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749007885 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 696749007886 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 696749007887 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 696749007888 putative heme binding site [chemical binding]; other site 696749007889 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 696749007890 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 696749007891 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 696749007892 catalytic site [active] 696749007893 subunit interface [polypeptide binding]; other site 696749007894 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 696749007895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749007896 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749007897 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 696749007898 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749007899 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749007900 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 696749007901 IMP binding site; other site 696749007902 dimer interface [polypeptide binding]; other site 696749007903 interdomain contacts; other site 696749007904 partial ornithine binding site; other site 696749007905 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 696749007906 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 696749007907 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 696749007908 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 696749007909 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 696749007910 trimer interface [polypeptide binding]; other site 696749007911 active site 696749007912 substrate binding site [chemical binding]; other site 696749007913 CoA binding site [chemical binding]; other site 696749007914 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696749007915 Ligand Binding Site [chemical binding]; other site 696749007916 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 696749007917 DNA binding site [nucleotide binding] 696749007918 active site 696749007919 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 696749007920 active site 696749007921 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 696749007922 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 696749007923 putative active site [active] 696749007924 putative metal binding site [ion binding]; other site 696749007925 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 696749007926 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 696749007927 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749007928 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 696749007929 potential frameshift: common BLAST hit: gi|213157636|ref|YP_002320434.1| biofilm-associated protein 696749007930 potential frameshift: common BLAST hit: gi|213157636|ref|YP_002320434.1| biofilm-associated protein 696749007931 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007932 potential frameshift: common BLAST hit: gi|213157636|ref|YP_002320434.1| biofilm-associated protein 696749007933 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007934 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007935 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007936 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007937 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 696749007938 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 696749007939 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 696749007940 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 696749007941 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007942 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007943 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 696749007944 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 696749007945 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 696749007946 Protein of unknown function (DUF808); Region: DUF808; cl01002 696749007947 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 696749007948 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 696749007949 active site 696749007950 HIGH motif; other site 696749007951 dimer interface [polypeptide binding]; other site 696749007952 KMSKS motif; other site 696749007953 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 696749007954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007955 CoA-ligase; Region: Ligase_CoA; cl02894 696749007956 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 696749007957 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749007958 CoA-ligase; Region: Ligase_CoA; cl02894 696749007959 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 696749007960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749007962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696749007963 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 696749007964 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696749007965 E3 interaction surface; other site 696749007966 lipoyl attachment site [posttranslational modification]; other site 696749007967 e3 binding domain; Region: E3_binding; pfam02817 696749007968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 696749007969 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 696749007970 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 696749007971 TPP-binding site [chemical binding]; other site 696749007972 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 696749007973 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 696749007974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 696749007975 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 696749007976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749007977 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 696749007978 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 696749007979 SdhC subunit interface [polypeptide binding]; other site 696749007980 proximal heme binding site [chemical binding]; other site 696749007981 cardiolipin binding site; other site 696749007982 Iron-sulfur protein interface; other site 696749007983 proximal quinone binding site [chemical binding]; other site 696749007984 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 696749007985 Iron-sulfur protein interface; other site 696749007986 proximal quinone binding site [chemical binding]; other site 696749007987 SdhD (CybS) interface [polypeptide binding]; other site 696749007988 proximal heme binding site [chemical binding]; other site 696749007989 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 696749007990 dimer interface [polypeptide binding]; other site 696749007991 Citrate synthase; Region: Citrate_synt; pfam00285 696749007992 active site 696749007993 citrylCoA binding site [chemical binding]; other site 696749007994 NADH binding [chemical binding]; other site 696749007995 cationic pore residues; other site 696749007996 oxalacetate/citrate binding site [chemical binding]; other site 696749007997 coenzyme A binding site [chemical binding]; other site 696749007998 catalytic triad [active] 696749007999 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 696749008000 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 696749008001 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 696749008002 active site residue [active] 696749008003 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 696749008004 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 696749008005 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 696749008006 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 696749008007 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 696749008008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696749008009 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 696749008010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696749008011 DNA binding residues [nucleotide binding] 696749008012 Protein of unknown function (DUF493); Region: DUF493; cl01102 696749008013 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 696749008014 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 696749008015 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 696749008016 putative active site [active] 696749008017 metal binding site [ion binding]; metal-binding site 696749008018 amino acid transporter; Region: 2A0306; TIGR00909 696749008019 Spore germination protein; Region: Spore_permease; cl15802 696749008020 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749008021 Helix-turn-helix domains; Region: HTH; cl00088 696749008022 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 696749008023 siroheme synthase; Provisional; Region: cysG; PRK10637 696749008024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008025 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 696749008026 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 696749008027 seryl-tRNA synthetase; Provisional; Region: PRK05431 696749008028 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 696749008029 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 696749008030 dimer interface [polypeptide binding]; other site 696749008031 active site 696749008032 motif 1; other site 696749008033 motif 2; other site 696749008034 motif 3; other site 696749008035 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 696749008036 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 696749008037 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 696749008038 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 696749008039 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 696749008040 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 696749008041 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 696749008042 substrate binding pocket [chemical binding]; other site 696749008043 chain length determination region; other site 696749008044 substrate-Mg2+ binding site; other site 696749008045 catalytic residues [active] 696749008046 aspartate-rich region 1; other site 696749008047 active site lid residues [active] 696749008048 aspartate-rich region 2; other site 696749008049 Site-specific recombinase; Region: SpecificRecomb; cl15411 696749008050 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 696749008051 active site 696749008052 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 696749008053 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749008054 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749008055 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 696749008056 Protein export membrane protein; Region: SecD_SecF; cl14618 696749008057 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 696749008058 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 696749008059 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 696749008060 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696749008061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008062 short chain dehydrogenase; Provisional; Region: PRK06181 696749008063 NAD(P) binding site [chemical binding]; other site 696749008064 active site 696749008065 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 696749008066 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 696749008067 HIGH motif; other site 696749008068 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 696749008069 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 696749008070 active site 696749008071 KMSKS motif; other site 696749008072 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 696749008073 tRNA binding surface [nucleotide binding]; other site 696749008074 anticodon binding site; other site 696749008075 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 696749008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749008077 Membrane transport protein; Region: Mem_trans; cl09117 696749008078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749008079 Helix-turn-helix domains; Region: HTH; cl00088 696749008080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696749008081 dimerization interface [polypeptide binding]; other site 696749008082 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 696749008083 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 696749008084 active site 696749008085 sensor protein QseC; Provisional; Region: PRK10337 696749008086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749008087 dimer interface [polypeptide binding]; other site 696749008088 phosphorylation site [posttranslational modification] 696749008089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749008090 ATP binding site [chemical binding]; other site 696749008091 Mg2+ binding site [ion binding]; other site 696749008092 G-X-G motif; other site 696749008093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 696749008094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749008095 active site 696749008096 phosphorylation site [posttranslational modification] 696749008097 intermolecular recognition site; other site 696749008098 dimerization interface [polypeptide binding]; other site 696749008099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749008100 DNA binding site [nucleotide binding] 696749008101 putative metal dependent hydrolase; Provisional; Region: PRK11598 696749008102 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 696749008103 Sulfatase; Region: Sulfatase; cl10460 696749008104 Porin subfamily; Region: Porin_2; pfam02530 696749008105 muropeptide transporter; Validated; Region: ampG; PRK11010 696749008106 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 696749008107 putative acyl-acceptor binding pocket; other site 696749008108 hypothetical protein; Provisional; Region: PRK10279 696749008109 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 696749008110 nucleophile elbow; other site 696749008111 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 696749008112 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 696749008113 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 696749008114 Protein of unknown function (DUF419); Region: DUF419; cl15265 696749008115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 696749008116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 696749008117 substrate binding pocket [chemical binding]; other site 696749008118 chain length determination region; other site 696749008119 substrate-Mg2+ binding site; other site 696749008120 catalytic residues [active] 696749008121 aspartate-rich region 1; other site 696749008122 active site lid residues [active] 696749008123 aspartate-rich region 2; other site 696749008124 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 696749008125 PrpF protein; Region: PrpF; pfam04303 696749008126 aromatic amino acid transporter; Provisional; Region: PRK10238 696749008127 chaperone protein HchA; Provisional; Region: PRK04155 696749008128 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 696749008129 conserved cys residue [active] 696749008130 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 696749008131 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 696749008132 NAD(P) binding site [chemical binding]; other site 696749008133 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 696749008134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749008135 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749008136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749008137 Bacitracin resistance protein BacA; Region: BacA; cl00858 696749008138 Mrr N-terminal domain; Region: Mrr_N; pfam14338 696749008139 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 696749008140 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 696749008141 putative di-iron ligands [ion binding]; other site 696749008142 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 696749008143 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749008144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749008145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749008146 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749008147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749008148 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749008149 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749008150 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 696749008151 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696749008152 Active Sites [active] 696749008153 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 696749008154 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 696749008155 ribonuclease G; Provisional; Region: PRK11712 696749008156 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 696749008157 homodimer interface [polypeptide binding]; other site 696749008158 oligonucleotide binding site [chemical binding]; other site 696749008159 Maf-like protein; Region: Maf; pfam02545 696749008160 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 696749008161 active site 696749008162 dimer interface [polypeptide binding]; other site 696749008163 rod shape-determining protein MreC; Provisional; Region: PRK13922 696749008164 rod shape-determining protein MreC; Region: MreC; pfam04085 696749008165 rod shape-determining protein MreB; Provisional; Region: PRK13927 696749008166 Cell division protein FtsA; Region: FtsA; cl11496 696749008167 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 696749008168 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 696749008169 Amidase; Region: Amidase; cl11426 696749008170 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 696749008171 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 696749008172 GatB domain; Region: GatB_Yqey; cl11497 696749008173 intracellular protease, PfpI family; Region: PfpI; TIGR01382 696749008174 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 696749008175 conserved cys residue [active] 696749008176 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 696749008177 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 696749008178 threonine dehydratase; Provisional; Region: PRK07334 696749008179 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 696749008180 tetramer interface [polypeptide binding]; other site 696749008181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749008182 catalytic residue [active] 696749008183 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 696749008184 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 696749008185 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 696749008186 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 696749008187 active site 696749008188 nucleophile elbow; other site 696749008189 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 696749008190 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 696749008191 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 696749008192 putative FMN binding site [chemical binding]; other site 696749008193 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 696749008194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749008195 putative substrate translocation pore; other site 696749008196 TIGR01666 family membrane protein; Region: YCCS 696749008197 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 696749008198 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 696749008199 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 696749008200 YcxB-like protein; Region: YcxB; pfam14317 696749008201 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 696749008202 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749008203 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 696749008204 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 696749008205 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749008206 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 696749008207 FAD binding pocket [chemical binding]; other site 696749008208 FAD binding motif [chemical binding]; other site 696749008209 catalytic residues [active] 696749008210 NAD binding pocket [chemical binding]; other site 696749008211 phosphate binding motif [ion binding]; other site 696749008212 beta-alpha-beta structure motif; other site 696749008213 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 696749008214 putative active site [active] 696749008215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 696749008216 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 696749008217 Protein of unknown function (DUF454); Region: DUF454; cl01063 696749008218 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 696749008219 Entericidin EcnA/B family; Region: Entericidin; cl02322 696749008220 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 696749008221 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 696749008222 metal binding site [ion binding]; metal-binding site 696749008223 dimer interface [polypeptide binding]; other site 696749008224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 696749008225 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 696749008226 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 696749008227 putative binding surface; other site 696749008228 active site 696749008229 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 696749008230 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 696749008231 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 696749008232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749008233 ATP binding site [chemical binding]; other site 696749008234 Mg2+ binding site [ion binding]; other site 696749008235 G-X-G motif; other site 696749008236 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 696749008237 Response regulator receiver domain; Region: Response_reg; pfam00072 696749008238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749008239 active site 696749008240 phosphorylation site [posttranslational modification] 696749008241 intermolecular recognition site; other site 696749008242 dimerization interface [polypeptide binding]; other site 696749008243 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 696749008244 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 696749008245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 696749008246 dimer interface [polypeptide binding]; other site 696749008247 putative CheW interface [polypeptide binding]; other site 696749008248 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 696749008249 Response regulator receiver domain; Region: Response_reg; pfam00072 696749008250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749008251 active site 696749008252 phosphorylation site [posttranslational modification] 696749008253 intermolecular recognition site; other site 696749008254 dimerization interface [polypeptide binding]; other site 696749008255 Response regulator receiver domain; Region: Response_reg; pfam00072 696749008256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749008257 active site 696749008258 phosphorylation site [posttranslational modification] 696749008259 intermolecular recognition site; other site 696749008260 dimerization interface [polypeptide binding]; other site 696749008261 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 696749008262 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749008263 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 696749008264 prolyl-tRNA synthetase; Provisional; Region: PRK09194 696749008265 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 696749008266 dimer interface [polypeptide binding]; other site 696749008267 motif 1; other site 696749008268 active site 696749008269 motif 2; other site 696749008270 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 696749008271 putative deacylase active site [active] 696749008272 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 696749008273 active site 696749008274 motif 3; other site 696749008275 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 696749008276 anticodon binding site; other site 696749008277 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 696749008278 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 696749008279 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 696749008280 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 696749008281 PhnA protein; Region: PhnA; pfam03831 696749008282 Protein of unknown function, DUF488; Region: DUF488; cl01246 696749008283 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 696749008284 putative hydrophobic ligand binding site [chemical binding]; other site 696749008285 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 696749008286 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 696749008287 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 696749008288 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 696749008289 dimerization domain [polypeptide binding]; other site 696749008290 dimer interface [polypeptide binding]; other site 696749008291 catalytic residues [active] 696749008292 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 696749008293 Sel1 repeat; Region: Sel1; cl02723 696749008294 Membrane transport protein; Region: Mem_trans; cl09117 696749008295 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 696749008296 active site 696749008297 FMN binding site [chemical binding]; other site 696749008298 substrate binding site [chemical binding]; other site 696749008299 homotetramer interface [polypeptide binding]; other site 696749008300 catalytic residue [active] 696749008301 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696749008302 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749008303 N-terminal plug; other site 696749008304 ligand-binding site [chemical binding]; other site 696749008305 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 696749008306 active site 696749008307 DNA binding site [nucleotide binding] 696749008308 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 696749008309 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 696749008310 DNA binding site [nucleotide binding] 696749008311 catalytic residue [active] 696749008312 H2TH interface [polypeptide binding]; other site 696749008313 putative catalytic residues [active] 696749008314 turnover-facilitating residue; other site 696749008315 intercalation triad [nucleotide binding]; other site 696749008316 8OG recognition residue [nucleotide binding]; other site 696749008317 putative reading head residues; other site 696749008318 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 696749008319 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 696749008320 PPIC-type PPIASE domain; Region: Rotamase; cl08278 696749008321 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 696749008322 putative active site pocket [active] 696749008323 dimerization interface [polypeptide binding]; other site 696749008324 putative catalytic residue [active] 696749008325 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 696749008326 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 696749008327 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 696749008328 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 696749008329 G1 box; other site 696749008330 putative GEF interaction site [polypeptide binding]; other site 696749008331 GTP/Mg2+ binding site [chemical binding]; other site 696749008332 Switch I region; other site 696749008333 G2 box; other site 696749008334 G3 box; other site 696749008335 Switch II region; other site 696749008336 G4 box; other site 696749008337 G5 box; other site 696749008338 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 696749008339 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 696749008340 xanthine permease; Region: pbuX; TIGR03173 696749008341 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 696749008342 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 696749008343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749008344 S-adenosylmethionine binding site [chemical binding]; other site 696749008345 lysine transporter; Provisional; Region: PRK10836 696749008346 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 696749008347 hypothetical protein; Reviewed; Region: PRK09588 696749008348 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 696749008349 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749008350 ligand binding site [chemical binding]; other site 696749008351 Type II transport protein GspH; Region: GspH; pfam12019 696749008352 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 696749008353 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749008354 dimer interface [polypeptide binding]; other site 696749008355 active site 696749008356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696749008357 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 696749008358 dimer interface [polypeptide binding]; other site 696749008359 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 696749008360 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 696749008361 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 696749008362 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 696749008363 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 696749008364 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 696749008365 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 696749008366 Trp docking motif [polypeptide binding]; other site 696749008367 putative active site [active] 696749008368 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 696749008369 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 696749008370 CoA-transferase family III; Region: CoA_transf_3; pfam02515 696749008371 formyl-coenzyme A transferase; Provisional; Region: PRK05398 696749008372 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749008373 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749008374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749008375 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 696749008376 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696749008377 dimer interface [polypeptide binding]; other site 696749008378 active site 696749008379 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 696749008380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749008381 substrate binding site [chemical binding]; other site 696749008382 oxyanion hole (OAH) forming residues; other site 696749008383 trimer interface [polypeptide binding]; other site 696749008384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008385 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696749008386 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 696749008387 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 696749008388 active site 696749008389 nucleophile elbow; other site 696749008390 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 696749008391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749008392 potential frameshift: common BLAST hit: gi|169794801|ref|YP_001712594.1| methyltransferase 696749008393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749008394 Methyltransferase domain; Region: Methyltransf_31; pfam13847 696749008395 Haemolysin-III related; Region: HlyIII; cl03831 696749008396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749008397 metabolite-proton symporter; Region: 2A0106; TIGR00883 696749008398 putative substrate translocation pore; other site 696749008399 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 696749008400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749008401 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 696749008402 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 696749008403 SEC-C motif; Region: SEC-C; pfam02810 696749008404 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 696749008405 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 696749008406 dimer interface [polypeptide binding]; other site 696749008407 decamer (pentamer of dimers) interface [polypeptide binding]; other site 696749008408 catalytic triad [active] 696749008409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749008410 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 696749008411 active site 696749008412 catalytic residues [active] 696749008413 Sporulation related domain; Region: SPOR; cl10051 696749008414 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 696749008415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749008416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749008417 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 696749008418 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749008419 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 696749008420 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 696749008421 substrate binding site [chemical binding]; other site 696749008422 active site 696749008423 catalytic residues [active] 696749008424 heterodimer interface [polypeptide binding]; other site 696749008425 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749008426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749008427 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749008428 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749008429 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 696749008430 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 696749008431 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 696749008432 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 696749008433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749008434 catalytic residue [active] 696749008435 potential frameshift: common BLAST hit: gi|184159443|ref|YP_001847782.1| phosphoribosylanthranilate isomerase 696749008436 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 696749008437 active site 696749008438 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 696749008439 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749008440 N-terminal plug; other site 696749008441 ligand-binding site [chemical binding]; other site 696749008442 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 696749008443 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 696749008444 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 696749008445 active site 696749008446 catalytic site [active] 696749008447 metal binding site [ion binding]; metal-binding site 696749008448 META domain; Region: META; cl01245 696749008449 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 696749008450 Di-iron ligands [ion binding]; other site 696749008451 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 696749008452 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 696749008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749008454 active site 696749008455 phosphorylation site [posttranslational modification] 696749008456 intermolecular recognition site; other site 696749008457 dimerization interface [polypeptide binding]; other site 696749008458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749008459 DNA binding site [nucleotide binding] 696749008460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 696749008461 dimerization interface [polypeptide binding]; other site 696749008462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749008463 dimer interface [polypeptide binding]; other site 696749008464 phosphorylation site [posttranslational modification] 696749008465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749008466 ATP binding site [chemical binding]; other site 696749008467 Mg2+ binding site [ion binding]; other site 696749008468 G-X-G motif; other site 696749008469 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 696749008470 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 696749008471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008472 active site 696749008473 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 696749008474 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 696749008475 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 696749008476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008477 active site 696749008478 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 696749008479 LysR family transcriptional regulator; Provisional; Region: PRK14997 696749008480 Helix-turn-helix domains; Region: HTH; cl00088 696749008481 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696749008482 putative effector binding pocket; other site 696749008483 dimerization interface [polypeptide binding]; other site 696749008484 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696749008485 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 696749008486 C-terminal domain interface [polypeptide binding]; other site 696749008487 GSH binding site (G-site) [chemical binding]; other site 696749008488 dimer interface [polypeptide binding]; other site 696749008489 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 696749008490 dimer interface [polypeptide binding]; other site 696749008491 substrate binding pocket (H-site) [chemical binding]; other site 696749008492 N-terminal domain interface [polypeptide binding]; other site 696749008493 Phosphate-starvation-inducible E; Region: PsiE; cl01264 696749008494 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 696749008495 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 696749008496 putative active site [active] 696749008497 putative catalytic site [active] 696749008498 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 696749008499 PLD-like domain; Region: PLDc_2; pfam13091 696749008500 putative active site [active] 696749008501 putative catalytic site [active] 696749008502 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 696749008503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749008504 N-terminal plug; other site 696749008505 ligand-binding site [chemical binding]; other site 696749008506 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 696749008507 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 696749008508 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 696749008509 dimer interface [polypeptide binding]; other site 696749008510 anticodon binding site; other site 696749008511 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 696749008512 homodimer interface [polypeptide binding]; other site 696749008513 motif 1; other site 696749008514 active site 696749008515 motif 2; other site 696749008516 GAD domain; Region: GAD; pfam02938 696749008517 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 696749008518 active site 696749008519 motif 3; other site 696749008520 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 696749008521 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 696749008522 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 696749008523 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 696749008524 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 696749008525 putative metal binding site; other site 696749008526 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 696749008527 putative active site [active] 696749008528 putative metal binding site [ion binding]; other site 696749008529 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696749008530 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 696749008531 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 696749008532 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 696749008533 homodimer interface [polypeptide binding]; other site 696749008534 substrate-cofactor binding pocket; other site 696749008535 catalytic residue [active] 696749008536 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 696749008537 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696749008538 metal binding triad; other site 696749008539 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 696749008540 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696749008541 metal binding triad; other site 696749008542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749008543 dimer interface [polypeptide binding]; other site 696749008544 phosphorylation site [posttranslational modification] 696749008545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749008546 ATP binding site [chemical binding]; other site 696749008547 Mg2+ binding site [ion binding]; other site 696749008548 G-X-G motif; other site 696749008549 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 696749008550 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 696749008551 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 696749008552 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 696749008553 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 696749008554 LemA family; Region: LemA; cl00742 696749008555 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 696749008556 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 696749008557 Preprotein translocase subunit; Region: YajC; cl00806 696749008558 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 696749008559 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 696749008560 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 696749008561 Protein export membrane protein; Region: SecD_SecF; cl14618 696749008562 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 696749008563 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 696749008564 Protein export membrane protein; Region: SecD_SecF; cl14618 696749008565 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 696749008566 Flavoprotein; Region: Flavoprotein; cl08021 696749008567 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 696749008568 hypothetical protein; Reviewed; Region: PRK00024 696749008569 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 696749008570 MPN+ (JAMM) motif; other site 696749008571 Zinc-binding site [ion binding]; other site 696749008572 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 696749008573 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 696749008574 Domain of unknown function (DUF365); Region: DUF365; cl00889 696749008575 Intracellular septation protein A; Region: IspA; cl01098 696749008576 YCII-related domain; Region: YCII; cl00999 696749008577 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 696749008578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749008579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008580 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 696749008581 active site residue [active] 696749008582 Protein of unknown function (DUF520); Region: DUF520; cl00723 696749008583 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696749008584 CoenzymeA binding site [chemical binding]; other site 696749008585 subunit interaction site [polypeptide binding]; other site 696749008586 PHB binding site; other site 696749008587 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 696749008588 thioredoxin 2; Provisional; Region: PRK10996 696749008589 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 696749008590 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 696749008591 catalytic residues [active] 696749008592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749008593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749008594 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 696749008595 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 696749008596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749008597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696749008598 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 696749008599 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 696749008600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749008601 metal binding site [ion binding]; metal-binding site 696749008602 active site 696749008603 I-site; other site 696749008604 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696749008605 ligand binding site [chemical binding]; other site 696749008606 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 696749008607 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 696749008608 putative active site [active] 696749008609 putative metal binding site [ion binding]; other site 696749008610 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 696749008611 putative active site [active] 696749008612 catalytic site [active] 696749008613 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 696749008614 PLD-like domain; Region: PLDc_2; pfam13091 696749008615 putative active site [active] 696749008616 catalytic site [active] 696749008617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 696749008618 putative acyl-acceptor binding pocket; other site 696749008619 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 696749008620 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 696749008621 HflX GTPase family; Region: HflX; cd01878 696749008622 G1 box; other site 696749008623 GTP/Mg2+ binding site [chemical binding]; other site 696749008624 Switch I region; other site 696749008625 G2 box; other site 696749008626 G3 box; other site 696749008627 Switch II region; other site 696749008628 G4 box; other site 696749008629 G5 box; other site 696749008630 LrgB-like family; Region: LrgB; cl00596 696749008631 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 696749008632 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 696749008633 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 696749008634 active site 696749008635 metal binding site [ion binding]; metal-binding site 696749008636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749008637 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 696749008638 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 696749008639 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 696749008640 23S rRNA interface [nucleotide binding]; other site 696749008641 L3 interface [polypeptide binding]; other site 696749008642 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 696749008643 stringent starvation protein A; Provisional; Region: sspA; PRK09481 696749008644 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 696749008645 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 696749008646 dimer interface [polypeptide binding]; other site 696749008647 N-terminal domain interface [polypeptide binding]; other site 696749008648 Stringent starvation protein B; Region: SspB; cl01120 696749008649 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 696749008650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696749008651 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749008652 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 696749008653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696749008654 carboxyltransferase (CT) interaction site; other site 696749008655 biotinylation site [posttranslational modification]; other site 696749008656 enoyl-CoA hydratase; Provisional; Region: PRK05995 696749008657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696749008658 substrate binding site [chemical binding]; other site 696749008659 oxyanion hole (OAH) forming residues; other site 696749008660 trimer interface [polypeptide binding]; other site 696749008661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749008662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008663 active site 696749008664 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 696749008665 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749008666 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 696749008667 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 696749008668 NAD(P) binding site [chemical binding]; other site 696749008669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 696749008670 substrate binding site [chemical binding]; other site 696749008671 homotetramer interface [polypeptide binding]; other site 696749008672 active site 696749008673 homodimer interface [polypeptide binding]; other site 696749008674 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 696749008675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749008676 Helix-turn-helix domains; Region: HTH; cl00088 696749008677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749008678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008679 active site 696749008680 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 696749008681 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 696749008682 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 696749008683 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 696749008684 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 696749008685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749008686 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 696749008687 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 696749008688 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 696749008689 malate dehydrogenase; Provisional; Region: PRK05442 696749008690 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 696749008691 NAD(P) binding site [chemical binding]; other site 696749008692 dimer interface [polypeptide binding]; other site 696749008693 malate binding site [chemical binding]; other site 696749008694 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 696749008695 B1 nucleotide binding pocket [chemical binding]; other site 696749008696 B2 nucleotide binding pocket [chemical binding]; other site 696749008697 CAS motifs; other site 696749008698 active site 696749008699 lytic murein transglycosylase; Provisional; Region: PRK11619 696749008700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749008701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749008702 catalytic residue [active] 696749008703 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 696749008704 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 696749008705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749008706 FeS/SAM binding site; other site 696749008707 TRAM domain; Region: TRAM; cl01282 696749008708 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 696749008709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749008710 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 696749008711 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 696749008712 Gram-negative bacterial tonB protein; Region: TonB; cl10048 696749008713 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 696749008714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749008715 active site 696749008716 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749008717 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 696749008718 EamA-like transporter family; Region: EamA; cl01037 696749008719 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749008720 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749008721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749008722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 696749008723 YcxB-like protein; Region: YcxB; pfam14317 696749008724 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 696749008725 dimer interface [polypeptide binding]; other site 696749008726 FMN binding site [chemical binding]; other site 696749008727 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 696749008728 ribonuclease R; Region: RNase_R; TIGR02063 696749008729 RNB domain; Region: RNB; pfam00773 696749008730 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 696749008731 RNA binding site [nucleotide binding]; other site 696749008732 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 696749008733 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 696749008734 active site 696749008735 Zn binding site [ion binding]; other site 696749008736 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 696749008737 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 696749008738 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 696749008739 Rhomboid family; Region: Rhomboid; cl11446 696749008740 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 696749008741 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 696749008742 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008743 active site 696749008744 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 696749008745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008746 NAD(P) binding pocket [chemical binding]; other site 696749008747 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 696749008748 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 696749008749 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 696749008750 alphaNTD homodimer interface [polypeptide binding]; other site 696749008751 alphaNTD - beta interaction site [polypeptide binding]; other site 696749008752 alphaNTD - beta' interaction site [polypeptide binding]; other site 696749008753 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 696749008754 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 696749008755 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 696749008756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696749008757 RNA binding surface [nucleotide binding]; other site 696749008758 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 696749008759 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 696749008760 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 696749008761 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 696749008762 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 696749008763 SecY translocase; Region: SecY; pfam00344 696749008764 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 696749008765 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 696749008766 23S rRNA binding site [nucleotide binding]; other site 696749008767 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 696749008768 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 696749008769 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 696749008770 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 696749008771 5S rRNA interface [nucleotide binding]; other site 696749008772 23S rRNA interface [nucleotide binding]; other site 696749008773 L5 interface [polypeptide binding]; other site 696749008774 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 696749008775 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 696749008776 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 696749008777 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 696749008778 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 696749008779 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 696749008780 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 696749008781 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 696749008782 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 696749008783 KOW motif; Region: KOW; cl00354 696749008784 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 696749008785 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 696749008786 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 696749008787 23S rRNA interface [nucleotide binding]; other site 696749008788 putative translocon interaction site; other site 696749008789 signal recognition particle (SRP54) interaction site; other site 696749008790 L23 interface [polypeptide binding]; other site 696749008791 trigger factor interaction site; other site 696749008792 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 696749008793 23S rRNA interface [nucleotide binding]; other site 696749008794 5S rRNA interface [nucleotide binding]; other site 696749008795 putative antibiotic binding site [chemical binding]; other site 696749008796 L25 interface [polypeptide binding]; other site 696749008797 L27 interface [polypeptide binding]; other site 696749008798 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 696749008799 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 696749008800 G-X-X-G motif; other site 696749008801 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 696749008802 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 696749008803 putative translocon binding site; other site 696749008804 protein-rRNA interface [nucleotide binding]; other site 696749008805 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 696749008806 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 696749008807 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 696749008808 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 696749008809 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 696749008810 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 696749008811 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 696749008812 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 696749008813 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 696749008814 catalytic triad [active] 696749008815 cystathionine beta-lyase; Provisional; Region: PRK07050 696749008816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 696749008817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696749008818 catalytic residue [active] 696749008819 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 696749008820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749008821 Walker A motif; other site 696749008822 ATP binding site [chemical binding]; other site 696749008823 Walker B motif; other site 696749008824 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 696749008825 heme-binding site [chemical binding]; other site 696749008826 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 696749008827 FAD binding pocket [chemical binding]; other site 696749008828 conserved FAD binding motif [chemical binding]; other site 696749008829 phosphate binding motif [ion binding]; other site 696749008830 Predicted transcriptional regulator [Transcription]; Region: COG1959 696749008831 Helix-turn-helix domains; Region: HTH; cl00088 696749008832 Predicted GTPase [General function prediction only]; Region: COG0218 696749008833 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 696749008834 G1 box; other site 696749008835 GTP/Mg2+ binding site [chemical binding]; other site 696749008836 Switch I region; other site 696749008837 G2 box; other site 696749008838 G3 box; other site 696749008839 Switch II region; other site 696749008840 G4 box; other site 696749008841 G5 box; other site 696749008842 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749008843 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749008844 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 696749008845 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 696749008846 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 696749008847 active site 696749008848 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 696749008849 catalytic triad [active] 696749008850 dimer interface [polypeptide binding]; other site 696749008851 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 696749008852 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 696749008853 putative acyl-acceptor binding pocket; other site 696749008854 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 696749008855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749008856 NADH(P)-binding; Region: NAD_binding_10; pfam13460 696749008857 NAD(P) binding site [chemical binding]; other site 696749008858 active site 696749008859 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 696749008860 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 696749008861 ssDNA binding site; other site 696749008862 generic binding surface II; other site 696749008863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696749008864 ATP binding site [chemical binding]; other site 696749008865 putative Mg++ binding site [ion binding]; other site 696749008866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749008867 nucleotide binding region [chemical binding]; other site 696749008868 ATP-binding site [chemical binding]; other site 696749008869 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 696749008870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749008871 active site 696749008872 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 696749008873 nudix motif; other site 696749008874 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 696749008875 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 696749008876 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 696749008877 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 696749008878 anti sigma factor interaction site; other site 696749008879 regulatory phosphorylation site [posttranslational modification]; other site 696749008880 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 696749008881 mce related protein; Region: MCE; pfam02470 696749008882 Permease; Region: Permease; cl00510 696749008883 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 696749008884 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 696749008885 Walker A/P-loop; other site 696749008886 ATP binding site [chemical binding]; other site 696749008887 Q-loop/lid; other site 696749008888 ABC transporter signature motif; other site 696749008889 Walker B; other site 696749008890 D-loop; other site 696749008891 H-loop/switch region; other site 696749008892 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 696749008893 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 696749008894 ATP binding site [chemical binding]; other site 696749008895 Mg++ binding site [ion binding]; other site 696749008896 motif III; other site 696749008897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696749008898 nucleotide binding region [chemical binding]; other site 696749008899 ATP-binding site [chemical binding]; other site 696749008900 transcription termination factor Rho; Provisional; Region: PRK12678 696749008901 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 696749008902 active site 696749008903 dimerization interface [polypeptide binding]; other site 696749008904 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 696749008905 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 696749008906 TPP-binding site; other site 696749008907 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 696749008908 PYR/PP interface [polypeptide binding]; other site 696749008909 dimer interface [polypeptide binding]; other site 696749008910 TPP binding site [chemical binding]; other site 696749008911 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696749008912 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 696749008913 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 696749008914 dimerization interface [polypeptide binding]; other site 696749008915 active site 696749008916 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 696749008917 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 696749008918 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 696749008919 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 696749008920 shikimate binding site; other site 696749008921 NAD(P) binding site [chemical binding]; other site 696749008922 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 696749008923 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 696749008924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 696749008925 active site 696749008926 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 696749008927 hypothetical protein; Provisional; Region: PRK11615 696749008928 PspC domain; Region: PspC; cl00864 696749008929 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 696749008930 HPP family; Region: HPP; pfam04982 696749008931 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 696749008932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 696749008933 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 696749008934 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 696749008935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696749008936 FeS/SAM binding site; other site 696749008937 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 696749008938 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 696749008939 dimer interface [polypeptide binding]; other site 696749008940 motif 1; other site 696749008941 active site 696749008942 motif 2; other site 696749008943 motif 3; other site 696749008944 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 696749008945 YCII-related domain; Region: YCII; cl00999 696749008946 EamA-like transporter family; Region: EamA; cl01037 696749008947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749008948 EamA-like transporter family; Region: EamA; cl01037 696749008949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749008950 Helix-turn-helix domains; Region: HTH; cl00088 696749008951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749008952 dimerization interface [polypeptide binding]; other site 696749008953 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 696749008954 active site 696749008955 catalytic residues [active] 696749008956 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 696749008957 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 696749008958 putative active site [active] 696749008959 Zn binding site [ion binding]; other site 696749008960 Succinylarginine dihydrolase; Region: AstB; cl01511 696749008961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749008962 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 696749008963 NAD(P) binding site [chemical binding]; other site 696749008964 catalytic residues [active] 696749008965 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 696749008966 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 696749008967 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749008968 inhibitor-cofactor binding pocket; inhibition site 696749008969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749008970 catalytic residue [active] 696749008971 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 696749008972 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 696749008973 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 696749008974 NAD(P) binding site [chemical binding]; other site 696749008975 S-methylmethionine transporter; Provisional; Region: PRK11387 696749008976 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 696749008977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749008978 S-adenosylmethionine binding site [chemical binding]; other site 696749008979 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 696749008980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 696749008981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749008982 P-loop; other site 696749008983 Magnesium ion binding site [ion binding]; other site 696749008984 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 696749008985 Domain of unknown function DUF20; Region: UPF0118; pfam01594 696749008986 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 696749008987 E-class dimer interface [polypeptide binding]; other site 696749008988 P-class dimer interface [polypeptide binding]; other site 696749008989 active site 696749008990 Cu2+ binding site [ion binding]; other site 696749008991 Zn2+ binding site [ion binding]; other site 696749008992 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 696749008993 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 696749008994 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 696749008995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749008996 putative substrate translocation pore; other site 696749008997 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749008998 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 696749008999 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 696749009000 FAD binding domain; Region: FAD_binding_4; pfam01565 696749009001 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 696749009002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009003 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 696749009004 L-serine binding site [chemical binding]; other site 696749009005 ACT domain interface; other site 696749009006 threonine and homoserine efflux system; Provisional; Region: PRK10532 696749009007 EamA-like transporter family; Region: EamA; cl01037 696749009008 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 696749009009 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 696749009010 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749009011 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696749009012 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 696749009013 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 696749009014 RNA binding site [nucleotide binding]; other site 696749009015 active site 696749009016 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 696749009017 lipase chaperone; Provisional; Region: PRK01294 696749009018 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 696749009019 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 696749009020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749009021 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 696749009022 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 696749009023 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 696749009024 RimM N-terminal domain; Region: RimM; pfam01782 696749009025 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 696749009026 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 696749009027 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 696749009028 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 696749009029 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 696749009030 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 696749009031 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 696749009032 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 696749009033 LytB protein; Region: LYTB; cl00507 696749009034 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 696749009035 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 696749009036 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 696749009037 catalytic site [active] 696749009038 G-X2-G-X-G-K; other site 696749009039 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 696749009040 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 696749009041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 696749009042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 696749009043 synthetase active site [active] 696749009044 NTP binding site [chemical binding]; other site 696749009045 metal binding site [ion binding]; metal-binding site 696749009046 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 696749009047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749009048 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 696749009049 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 696749009050 homotrimer interaction site [polypeptide binding]; other site 696749009051 putative active site [active] 696749009052 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 696749009053 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 696749009054 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 696749009055 heme binding site [chemical binding]; other site 696749009056 ferroxidase pore; other site 696749009057 ferroxidase diiron center [ion binding]; other site 696749009058 O-Antigen ligase; Region: Wzy_C; cl04850 696749009059 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 696749009060 O-Antigen ligase; Region: Wzy_C; cl04850 696749009061 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749009062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749009063 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 696749009064 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 696749009065 Pilin (bacterial filament); Region: Pilin; pfam00114 696749009066 Repair protein; Region: Repair_PSII; cl01535 696749009067 Repair protein; Region: Repair_PSII; cl01535 696749009068 LemA family; Region: LemA; cl00742 696749009069 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 696749009070 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 696749009071 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 696749009072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696749009074 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 696749009075 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 696749009076 active site 696749009077 dimer interface [polypeptide binding]; other site 696749009078 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 696749009079 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 696749009080 active site 696749009081 FMN binding site [chemical binding]; other site 696749009082 substrate binding site [chemical binding]; other site 696749009083 3Fe-4S cluster binding site [ion binding]; other site 696749009084 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 696749009085 domain interface; other site 696749009086 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 696749009087 active site 696749009088 dimer interface [polypeptide binding]; other site 696749009089 metal binding site [ion binding]; metal-binding site 696749009090 shikimate kinase; Reviewed; Region: aroK; PRK00131 696749009091 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 696749009092 ADP binding site [chemical binding]; other site 696749009093 magnesium binding site [ion binding]; other site 696749009094 putative shikimate binding site; other site 696749009095 AMIN domain; Region: AMIN; pfam11741 696749009096 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 696749009097 Secretin and TonB N terminus short domain; Region: STN; cl06624 696749009098 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 696749009099 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 696749009100 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 696749009101 Pilus assembly protein, PilP; Region: PilP; pfam04351 696749009102 Pilus assembly protein, PilO; Region: PilO; cl01234 696749009103 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 696749009104 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 696749009105 Competence protein A; Region: Competence_A; pfam11104 696749009106 Cell division protein FtsA; Region: FtsA; cl11496 696749009107 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 696749009108 Transglycosylase; Region: Transgly; cl07896 696749009109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749009110 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 696749009111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749009112 S-adenosylmethionine binding site [chemical binding]; other site 696749009113 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 696749009114 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 696749009115 Mg++ binding site [ion binding]; other site 696749009116 putative catalytic motif [active] 696749009117 putative substrate binding site [chemical binding]; other site 696749009118 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696749009119 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 696749009120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749009121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749009122 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 696749009123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749009124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749009125 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 696749009126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 696749009127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 696749009128 Septum formation initiator; Region: DivIC; cl11433 696749009129 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 696749009130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 696749009131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749009132 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 696749009133 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 696749009134 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 696749009135 active site 696749009136 HIGH motif; other site 696749009137 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 696749009138 active site 696749009139 KMSKS motif; other site 696749009140 S-methylmethionine transporter; Provisional; Region: PRK11387 696749009141 Spore germination protein; Region: Spore_permease; cl15802 696749009142 Cation efflux family; Region: Cation_efflux; cl00316 696749009143 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 696749009144 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749009145 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 696749009146 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749009147 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 696749009148 hypothetical protein; Provisional; Region: PRK10215 696749009149 Sel1 repeat; Region: Sel1; cl02723 696749009150 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 696749009151 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749009152 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749009153 ABC transporter; Region: ABC_tran_2; pfam12848 696749009154 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 696749009155 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 696749009156 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 696749009157 homodimer interface [polypeptide binding]; other site 696749009158 substrate-cofactor binding pocket; other site 696749009159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749009160 catalytic residue [active] 696749009161 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 696749009162 classical (c) SDRs; Region: SDR_c; cd05233 696749009163 NAD(P) binding site [chemical binding]; other site 696749009164 active site 696749009165 Sulfate transporter family; Region: Sulfate_transp; cl15842 696749009166 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 696749009167 active site clefts [active] 696749009168 zinc binding site [ion binding]; other site 696749009169 dimer interface [polypeptide binding]; other site 696749009170 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 696749009171 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 696749009172 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 696749009173 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 696749009174 RNA binding site [nucleotide binding]; other site 696749009175 osmolarity response regulator; Provisional; Region: ompR; PRK09468 696749009176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749009177 active site 696749009178 phosphorylation site [posttranslational modification] 696749009179 intermolecular recognition site; other site 696749009180 dimerization interface [polypeptide binding]; other site 696749009181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749009182 DNA binding site [nucleotide binding] 696749009183 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 696749009184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 696749009185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749009186 dimer interface [polypeptide binding]; other site 696749009187 phosphorylation site [posttranslational modification] 696749009188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749009189 ATP binding site [chemical binding]; other site 696749009190 Mg2+ binding site [ion binding]; other site 696749009191 G-X-G motif; other site 696749009192 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 696749009193 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 696749009194 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 696749009195 putative acetyltransferase; Provisional; Region: PRK03624 696749009196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749009197 Coenzyme A binding pocket [chemical binding]; other site 696749009198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696749009199 Coenzyme A binding pocket [chemical binding]; other site 696749009200 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 696749009201 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 696749009202 putative active site pocket [active] 696749009203 4-fold oligomerization interface [polypeptide binding]; other site 696749009204 metal binding residues [ion binding]; metal-binding site 696749009205 3-fold/trimer interface [polypeptide binding]; other site 696749009206 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 696749009207 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 696749009208 putative active site [active] 696749009209 oxyanion strand; other site 696749009210 catalytic triad [active] 696749009211 Protein of unknown function (DUF805); Region: DUF805; cl01224 696749009212 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 696749009213 catalytic site [active] 696749009214 putative active site [active] 696749009215 putative substrate binding site [chemical binding]; other site 696749009216 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 696749009217 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 696749009218 catalytic residues [active] 696749009219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749009220 non-specific DNA binding site [nucleotide binding]; other site 696749009221 salt bridge; other site 696749009222 sequence-specific DNA binding site [nucleotide binding]; other site 696749009223 EamA-like transporter family; Region: EamA; cl01037 696749009224 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749009225 Predicted membrane protein [Function unknown]; Region: COG3671 696749009226 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 696749009227 DNA-binding site [nucleotide binding]; DNA binding site 696749009228 RNA-binding motif; other site 696749009229 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 696749009230 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 696749009231 Phosphotransferase enzyme family; Region: APH; pfam01636 696749009232 putative active site [active] 696749009233 putative substrate binding site [chemical binding]; other site 696749009234 ATP binding site [chemical binding]; other site 696749009235 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 696749009236 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 696749009237 substrate binding site [chemical binding]; other site 696749009238 glutamase interaction surface [polypeptide binding]; other site 696749009239 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 696749009240 Helix-turn-helix domain; Region: HTH_18; pfam12833 696749009241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749009242 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 696749009243 amphipathic channel; other site 696749009244 Asn-Pro-Ala signature motifs; other site 696749009245 LysE type translocator; Region: LysE; cl00565 696749009246 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 696749009247 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 696749009248 active site 696749009249 substrate binding site [chemical binding]; other site 696749009250 Mg2+ binding site [ion binding]; other site 696749009251 K+ potassium transporter; Region: K_trans; cl15781 696749009252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749009253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749009254 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 696749009255 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 696749009256 conserved cys residue [active] 696749009257 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749009258 Helix-turn-helix domains; Region: HTH; cl00088 696749009259 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 696749009260 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749009261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749009262 Helix-turn-helix domains; Region: HTH; cl00088 696749009263 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 696749009264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749009265 Helix-turn-helix domains; Region: HTH; cl00088 696749009266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696749009267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696749009268 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 696749009269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 696749009270 active site 696749009271 catalytic tetrad [active] 696749009272 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696749009273 EamA-like transporter family; Region: EamA; cl01037 696749009274 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 696749009275 Helix-turn-helix domains; Region: HTH; cl00088 696749009276 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 696749009277 putative dimerization interface [polypeptide binding]; other site 696749009278 putative substrate binding pocket [chemical binding]; other site 696749009279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749009280 putative substrate translocation pore; other site 696749009281 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 696749009282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749009283 S-adenosylmethionine binding site [chemical binding]; other site 696749009284 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 696749009285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009286 Pirin-related protein [General function prediction only]; Region: COG1741 696749009287 Cupin domain; Region: Cupin_2; cl09118 696749009288 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 696749009289 Isochorismatase family; Region: Isochorismatase; pfam00857 696749009290 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 696749009291 catalytic triad [active] 696749009292 dimer interface [polypeptide binding]; other site 696749009293 conserved cis-peptide bond; other site 696749009294 LysR family transcriptional regulator; Provisional; Region: PRK14997 696749009295 Helix-turn-helix domains; Region: HTH; cl00088 696749009296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749009297 dimerization interface [polypeptide binding]; other site 696749009298 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696749009299 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 696749009300 tetramerization interface [polypeptide binding]; other site 696749009301 NAD(P) binding site [chemical binding]; other site 696749009302 catalytic residues [active] 696749009303 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 696749009304 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696749009305 inhibitor-cofactor binding pocket; inhibition site 696749009306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749009307 catalytic residue [active] 696749009308 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749009309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749009310 DNA-binding site [nucleotide binding]; DNA binding site 696749009311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749009312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749009313 homodimer interface [polypeptide binding]; other site 696749009314 catalytic residue [active] 696749009315 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 696749009316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696749009317 non-specific DNA binding site [nucleotide binding]; other site 696749009318 salt bridge; other site 696749009319 sequence-specific DNA binding site [nucleotide binding]; other site 696749009320 Cupin domain; Region: Cupin_2; cl09118 696749009321 AzlC protein; Region: AzlC; cl00570 696749009322 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 696749009323 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 696749009324 dimer interface [polypeptide binding]; other site 696749009325 ssDNA binding site [nucleotide binding]; other site 696749009326 tetramer (dimer of dimers) interface [polypeptide binding]; other site 696749009327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749009328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696749009329 putative substrate translocation pore; other site 696749009330 Integral membrane protein TerC family; Region: TerC; cl10468 696749009331 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 696749009332 GlpM protein; Region: GlpM; cl01212 696749009333 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 696749009334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 696749009335 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 696749009336 putative NAD(P) binding site [chemical binding]; other site 696749009337 putative dimer interface [polypeptide binding]; other site 696749009338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749009339 Helix-turn-helix domains; Region: HTH; cl00088 696749009340 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 696749009341 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 696749009342 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 696749009343 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 696749009344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749009345 metal binding site [ion binding]; metal-binding site 696749009346 active site 696749009347 I-site; other site 696749009348 BCCT family transporter; Region: BCCT; cl00569 696749009349 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 696749009350 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 696749009351 Na binding site [ion binding]; other site 696749009352 Protein of unknown function, DUF485; Region: DUF485; cl01231 696749009353 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 696749009354 Na binding site [ion binding]; other site 696749009355 PAS fold; Region: PAS_7; pfam12860 696749009356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749009357 dimer interface [polypeptide binding]; other site 696749009358 phosphorylation site [posttranslational modification] 696749009359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749009360 ATP binding site [chemical binding]; other site 696749009361 Mg2+ binding site [ion binding]; other site 696749009362 G-X-G motif; other site 696749009363 Response regulator receiver domain; Region: Response_reg; pfam00072 696749009364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749009365 active site 696749009366 phosphorylation site [posttranslational modification] 696749009367 intermolecular recognition site; other site 696749009368 dimerization interface [polypeptide binding]; other site 696749009369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 696749009370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749009371 active site 696749009372 phosphorylation site [posttranslational modification] 696749009373 intermolecular recognition site; other site 696749009374 dimerization interface [polypeptide binding]; other site 696749009375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696749009376 DNA binding residues [nucleotide binding] 696749009377 dimerization interface [polypeptide binding]; other site 696749009378 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 696749009379 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 696749009380 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 696749009381 active site 696749009382 dimer interface [polypeptide binding]; other site 696749009383 non-prolyl cis peptide bond; other site 696749009384 insertion regions; other site 696749009385 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 696749009386 Helix-turn-helix domains; Region: HTH; cl00088 696749009387 AsnC family; Region: AsnC_trans_reg; pfam01037 696749009388 Isochorismatase family; Region: Isochorismatase; pfam00857 696749009389 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 696749009390 catalytic triad [active] 696749009391 conserved cis-peptide bond; other site 696749009392 acetyl-CoA synthetase; Provisional; Region: PRK00174 696749009393 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 696749009394 AMP-binding enzyme; Region: AMP-binding; cl15778 696749009395 AMP-binding enzyme; Region: AMP-binding; cl15778 696749009396 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 696749009397 Protein of unknown function (DUF805); Region: DUF805; cl01224 696749009398 OpgC protein; Region: OpgC_C; cl00792 696749009399 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696749009400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 696749009401 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 696749009402 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 696749009403 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 696749009404 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 696749009405 FMN binding site [chemical binding]; other site 696749009406 active site 696749009407 substrate binding site [chemical binding]; other site 696749009408 catalytic residue [active] 696749009409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696749009410 putative DNA binding site [nucleotide binding]; other site 696749009411 dimerization interface [polypeptide binding]; other site 696749009412 putative Zn2+ binding site [ion binding]; other site 696749009413 peptide chain release factor 2; Provisional; Region: PRK08787 696749009414 RF-1 domain; Region: RF-1; cl02875 696749009415 RF-1 domain; Region: RF-1; cl02875 696749009416 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 696749009417 DHH family; Region: DHH; pfam01368 696749009418 DHHA1 domain; Region: DHHA1; pfam02272 696749009419 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 696749009420 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 696749009421 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 696749009422 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 696749009423 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 696749009424 active site 696749009425 substrate binding site [chemical binding]; other site 696749009426 metal binding site [ion binding]; metal-binding site 696749009427 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 696749009428 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 696749009429 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 696749009430 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 696749009431 active site 696749009432 Flagellin N-methylase; Region: FliB; cl00497 696749009433 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696749009434 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 696749009435 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749009436 N-terminal plug; other site 696749009437 ligand-binding site [chemical binding]; other site 696749009438 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749009439 Predicted membrane protein [Function unknown]; Region: COG2119 696749009440 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 696749009441 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 696749009442 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696749009443 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 696749009444 E3 interaction surface; other site 696749009445 lipoyl attachment site [posttranslational modification]; other site 696749009446 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696749009447 E3 interaction surface; other site 696749009448 lipoyl attachment site [posttranslational modification]; other site 696749009449 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696749009450 E3 interaction surface; other site 696749009451 lipoyl attachment site [posttranslational modification]; other site 696749009452 e3 binding domain; Region: E3_binding; pfam02817 696749009453 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 696749009454 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 696749009455 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 696749009456 dimer interface [polypeptide binding]; other site 696749009457 TPP-binding site [chemical binding]; other site 696749009458 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 696749009459 Peptidase family M23; Region: Peptidase_M23; pfam01551 696749009460 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 696749009461 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 696749009462 cell division protein FtsZ; Validated; Region: PRK09330 696749009463 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 696749009464 nucleotide binding site [chemical binding]; other site 696749009465 SulA interaction site; other site 696749009466 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 696749009467 Cell division protein FtsA; Region: FtsA; cl11496 696749009468 Cell division protein FtsA; Region: FtsA; cl11496 696749009469 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 696749009470 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 696749009471 Cell division protein FtsQ; Region: FtsQ; pfam03799 696749009472 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 696749009473 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 696749009474 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749009475 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 696749009476 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696749009477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696749009478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696749009479 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 696749009480 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 696749009481 active site 696749009482 homodimer interface [polypeptide binding]; other site 696749009483 glutathione synthetase; Provisional; Region: PRK05246 696749009484 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 696749009485 ATP-grasp domain; Region: ATP-grasp_4; cl03087 696749009486 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 696749009487 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696749009488 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749009489 N-terminal plug; other site 696749009490 ligand-binding site [chemical binding]; other site 696749009491 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696749009492 active site 696749009493 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 696749009494 putative active site [active] 696749009495 putative catalytic site [active] 696749009496 putative DNA binding site [nucleotide binding]; other site 696749009497 putative phosphate binding site [ion binding]; other site 696749009498 metal binding site A [ion binding]; metal-binding site 696749009499 putative AP binding site [nucleotide binding]; other site 696749009500 putative metal binding site B [ion binding]; other site 696749009501 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 696749009502 ArsC family; Region: ArsC; pfam03960 696749009503 putative catalytic residues [active] 696749009504 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 696749009505 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749009506 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 696749009507 potential frameshift: common BLAST hit: gi|213159087|ref|YP_002321084.1| diguanylate cyclase 696749009508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 696749009509 metal binding site [ion binding]; metal-binding site 696749009510 active site 696749009511 I-site; other site 696749009512 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 696749009513 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 696749009514 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 696749009515 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 696749009516 DsbD alpha interface [polypeptide binding]; other site 696749009517 catalytic residues [active] 696749009518 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 696749009519 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 696749009520 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 696749009521 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 696749009522 30S subunit binding site; other site 696749009523 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 696749009524 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 696749009525 active site 696749009526 catalytic site [active] 696749009527 tetramer interface [polypeptide binding]; other site 696749009528 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 696749009529 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 696749009530 active site 696749009531 homotetramer interface [polypeptide binding]; other site 696749009532 xanthine permease; Region: pbuX; TIGR03173 696749009533 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 696749009534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009535 FAD binding domain; Region: FAD_binding_3; pfam01494 696749009536 allantoicase; Region: allantoicase; TIGR02961 696749009537 Allantoicase repeat; Region: Allantoicase; pfam03561 696749009538 Allantoicase repeat; Region: Allantoicase; pfam03561 696749009539 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 696749009540 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 696749009541 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 696749009542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749009543 ATP binding site [chemical binding]; other site 696749009544 Mg2+ binding site [ion binding]; other site 696749009545 G-X-G motif; other site 696749009546 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 696749009547 anchoring element; other site 696749009548 dimer interface [polypeptide binding]; other site 696749009549 ATP binding site [chemical binding]; other site 696749009550 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 696749009551 active site 696749009552 metal binding site [ion binding]; metal-binding site 696749009553 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 696749009554 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 696749009555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749009556 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749009557 Bacterial SH3 domain; Region: SH3_3; cl02551 696749009558 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 696749009559 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696749009560 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 696749009561 NlpC/P60 family; Region: NLPC_P60; cl11438 696749009562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 696749009563 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 696749009564 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 696749009565 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 696749009566 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 696749009567 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 696749009568 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 696749009569 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 696749009570 Protein of unknown function (DUF445); Region: DUF445; pfam04286 696749009571 methionine aminotransferase; Validated; Region: PRK09082 696749009572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749009573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749009574 homodimer interface [polypeptide binding]; other site 696749009575 catalytic residue [active] 696749009576 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 696749009577 MatE; Region: MatE; cl10513 696749009578 MatE; Region: MatE; cl10513 696749009579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009580 short chain dehydrogenase; Provisional; Region: PRK07832 696749009581 NAD(P) binding site [chemical binding]; other site 696749009582 active site 696749009583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749009584 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 696749009585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696749009586 active site 696749009587 phosphorylation site [posttranslational modification] 696749009588 intermolecular recognition site; other site 696749009589 dimerization interface [polypeptide binding]; other site 696749009590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696749009591 DNA binding site [nucleotide binding] 696749009592 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 696749009593 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 696749009594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 696749009595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696749009596 dimer interface [polypeptide binding]; other site 696749009597 phosphorylation site [posttranslational modification] 696749009598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696749009599 ATP binding site [chemical binding]; other site 696749009600 Mg2+ binding site [ion binding]; other site 696749009601 G-X-G motif; other site 696749009602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696749009603 Secretory lipase; Region: LIP; pfam03583 696749009604 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 696749009605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749009606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749009607 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 696749009608 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 696749009609 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 696749009610 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 696749009611 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 696749009612 active site residue [active] 696749009613 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 696749009614 active site residue [active] 696749009615 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 696749009616 active site 696749009617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 696749009618 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 696749009619 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 696749009620 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 696749009621 tetramer interface [polypeptide binding]; other site 696749009622 heme binding pocket [chemical binding]; other site 696749009623 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 696749009624 putative active site [active] 696749009625 dimerization interface [polypeptide binding]; other site 696749009626 putative tRNAtyr binding site [nucleotide binding]; other site 696749009627 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 696749009628 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 696749009629 phosphoserine phosphatase SerB; Region: serB; TIGR00338 696749009630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749009631 motif II; other site 696749009632 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 696749009633 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 696749009634 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 696749009635 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 696749009636 dimerization interface [polypeptide binding]; other site 696749009637 active site 696749009638 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 696749009639 homopentamer interface [polypeptide binding]; other site 696749009640 active site 696749009641 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 696749009642 thiamine monophosphate kinase; Provisional; Region: PRK05731 696749009643 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 696749009644 ATP binding site [chemical binding]; other site 696749009645 dimerization interface [polypeptide binding]; other site 696749009646 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 696749009647 tetramer interfaces [polypeptide binding]; other site 696749009648 binuclear metal-binding site [ion binding]; other site 696749009649 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 696749009650 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 696749009651 Substrate binding site; other site 696749009652 Mg++ binding site; other site 696749009653 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 696749009654 active site 696749009655 substrate binding site [chemical binding]; other site 696749009656 CoA binding site [chemical binding]; other site 696749009657 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 696749009658 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 696749009659 glutaminase active site [active] 696749009660 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 696749009661 dimer interface [polypeptide binding]; other site 696749009662 active site 696749009663 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 696749009664 dimer interface [polypeptide binding]; other site 696749009665 active site 696749009666 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 696749009667 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 696749009668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696749009669 motif II; other site 696749009670 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 696749009671 Arginase family; Region: Arginase; cl00306 696749009672 imidazolonepropionase; Validated; Region: PRK09356 696749009673 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 696749009674 active site 696749009675 putative proline-specific permease; Provisional; Region: proY; PRK10580 696749009676 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 696749009677 active sites [active] 696749009678 tetramer interface [polypeptide binding]; other site 696749009679 urocanate hydratase; Provisional; Region: PRK05414 696749009680 HutD; Region: HutD; cl01532 696749009681 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 696749009682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749009683 DNA-binding site [nucleotide binding]; DNA binding site 696749009684 UTRA domain; Region: UTRA; cl01230 696749009685 Acyltransferase family; Region: Acyl_transf_3; pfam01757 696749009686 OpgC protein; Region: OpgC_C; cl00792 696749009687 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 696749009688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749009689 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 696749009690 Peptidase M15; Region: Peptidase_M15_3; cl01194 696749009691 aromatic amino acid transporter; Provisional; Region: PRK10238 696749009692 Spore germination protein; Region: Spore_permease; cl15802 696749009693 fumarylacetoacetase; Region: PLN02856 696749009694 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 696749009695 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 696749009696 glutathione S-transferase; Provisional; Region: PRK15113 696749009697 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 696749009698 dimer interface [polypeptide binding]; other site 696749009699 N-terminal domain interface [polypeptide binding]; other site 696749009700 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 696749009701 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 696749009702 active site 696749009703 metal binding site [ion binding]; metal-binding site 696749009704 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696749009705 Helix-turn-helix domains; Region: HTH; cl00088 696749009706 Bacterial transcriptional regulator; Region: IclR; pfam01614 696749009707 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 696749009708 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 696749009709 dimer interface [polypeptide binding]; other site 696749009710 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 696749009711 active site 696749009712 Fe binding site [ion binding]; other site 696749009713 Protein of unknown function (DUF523); Region: DUF523; cl00733 696749009714 putative efflux protein, MATE family; Region: matE; TIGR00797 696749009715 MatE; Region: MatE; cl10513 696749009716 MatE; Region: MatE; cl10513 696749009717 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 696749009718 Membrane transport protein; Region: Mem_trans; cl09117 696749009719 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 696749009720 Isochorismatase family; Region: Isochorismatase; pfam00857 696749009721 catalytic triad [active] 696749009722 metal binding site [ion binding]; metal-binding site 696749009723 conserved cis-peptide bond; other site 696749009724 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 696749009725 dihydrodipicolinate synthase; Region: dapA; TIGR00674 696749009726 dimer interface [polypeptide binding]; other site 696749009727 active site 696749009728 catalytic residue [active] 696749009729 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 696749009730 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 696749009731 ATP binding site [chemical binding]; other site 696749009732 active site 696749009733 substrate binding site [chemical binding]; other site 696749009734 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 696749009735 recombination factor protein RarA; Reviewed; Region: PRK13342 696749009736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696749009737 Walker A motif; other site 696749009738 ATP binding site [chemical binding]; other site 696749009739 Walker B motif; other site 696749009740 arginine finger; other site 696749009741 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 696749009742 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 696749009743 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 696749009744 Flagellin N-methylase; Region: FliB; cl00497 696749009745 hypothetical protein; Provisional; Region: PRK13682 696749009746 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 696749009747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 696749009748 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 696749009749 nucleotide binding site/active site [active] 696749009750 HIT family signature motif; other site 696749009751 catalytic residue [active] 696749009752 potential frameshift: common BLAST hit: gi|184159947|ref|YP_001848286.1| A/G-specific DNA glycosylase 696749009753 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 696749009754 endonuclease III; Region: ENDO3c; smart00478 696749009755 minor groove reading motif; other site 696749009756 helix-hairpin-helix signature motif; other site 696749009757 substrate binding pocket [chemical binding]; other site 696749009758 active site 696749009759 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 696749009760 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 696749009761 Peptidase family M23; Region: Peptidase_M23; pfam01551 696749009762 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 696749009763 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 696749009764 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 696749009765 putative NAD(P) binding site [chemical binding]; other site 696749009766 putative substrate binding site [chemical binding]; other site 696749009767 catalytic Zn binding site [ion binding]; other site 696749009768 structural Zn binding site [ion binding]; other site 696749009769 dimer interface [polypeptide binding]; other site 696749009770 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696749009771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696749009772 DNA-binding site [nucleotide binding]; DNA binding site 696749009773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696749009774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696749009775 homodimer interface [polypeptide binding]; other site 696749009776 catalytic residue [active] 696749009777 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 696749009778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749009779 Helix-turn-helix domains; Region: HTH; cl00088 696749009780 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 696749009781 putative effector binding pocket; other site 696749009782 dimerization interface [polypeptide binding]; other site 696749009783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 696749009784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 696749009785 active site 696749009786 catalytic tetrad [active] 696749009787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696749009788 putative substrate translocation pore; other site 696749009789 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 696749009790 putative lipid binding site [chemical binding]; other site 696749009791 dihydrodipicolinate reductase; Provisional; Region: PRK00048 696749009792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696749009793 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 696749009794 chaperone protein DnaJ; Provisional; Region: PRK10767 696749009795 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 696749009796 HSP70 interaction site [polypeptide binding]; other site 696749009797 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 696749009798 substrate binding site [polypeptide binding]; other site 696749009799 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 696749009800 Zn binding sites [ion binding]; other site 696749009801 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 696749009802 dimer interface [polypeptide binding]; other site 696749009803 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 696749009804 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 696749009805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 696749009806 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 696749009807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696749009808 Helix-turn-helix domains; Region: HTH; cl00088 696749009809 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 696749009810 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 696749009811 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 696749009812 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 696749009813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696749009814 Helix-turn-helix domains; Region: HTH; cl00088 696749009815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696749009816 dimerization interface [polypeptide binding]; other site 696749009817 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 696749009818 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696749009819 Dehydratase family; Region: ILVD_EDD; cl00340 696749009820 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 696749009821 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 696749009822 putative active site [active] 696749009823 substrate binding site [chemical binding]; other site 696749009824 putative cosubstrate binding site; other site 696749009825 catalytic site [active] 696749009826 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 696749009827 substrate binding site [chemical binding]; other site 696749009828 16S rRNA methyltransferase B; Provisional; Region: PRK10901 696749009829 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 696749009830 putative RNA binding site [nucleotide binding]; other site 696749009831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696749009832 S-adenosylmethionine binding site [chemical binding]; other site 696749009833 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 696749009834 Na2 binding site [ion binding]; other site 696749009835 putative substrate binding site 1 [chemical binding]; other site 696749009836 Na binding site 1 [ion binding]; other site 696749009837 putative substrate binding site 2 [chemical binding]; other site 696749009838 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 696749009839 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696749009840 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 696749009841 putative C-terminal domain interface [polypeptide binding]; other site 696749009842 putative GSH binding site (G-site) [chemical binding]; other site 696749009843 putative dimer interface [polypeptide binding]; other site 696749009844 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 696749009845 dimer interface [polypeptide binding]; other site 696749009846 N-terminal domain interface [polypeptide binding]; other site 696749009847 substrate binding pocket (H-site) [chemical binding]; other site 696749009848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 696749009849 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 696749009850 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 696749009851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749009852 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 696749009853 Walker A motif; other site 696749009854 ATP binding site [chemical binding]; other site 696749009855 Walker B motif; other site 696749009856 TrwC relaxase; Region: TrwC; pfam08751 696749009857 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 696749009858 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 696749009859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 696749009860 Family description; Region: UvrD_C_2; cl15862 696749009861 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 696749009862 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 696749009863 catalytic residues [active] 696749009864 catalytic nucleophile [active] 696749009865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 696749009866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696749009867 catalytic residue [active] 696749009868 TraL protein; Region: TraL; cl06278 696749009869 TraE protein; Region: TraE; cl05060 696749009870 TraK protein; Region: TraK; pfam06586 696749009871 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 696749009872 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 696749009873 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 696749009874 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 696749009875 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 696749009876 dimerization domain [polypeptide binding]; other site 696749009877 dimer interface [polypeptide binding]; other site 696749009878 catalytic residues [active] 696749009879 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 696749009880 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 696749009881 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 696749009882 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 696749009883 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 696749009884 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 696749009885 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 696749009886 TraU protein; Region: TraU; cl06067 696749009887 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 696749009888 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 696749009889 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 696749009890 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 696749009891 catalytic residues [active] 696749009892 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 696749009893 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 696749009894 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 696749009895 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 696749009896 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 696749009897 active site 696749009898 DNA binding site [nucleotide binding] 696749009899 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 696749009900 ParB-like nuclease domain; Region: ParBc; cl02129 696749009901 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 696749009902 Replicase family; Region: Replicase; pfam03090 696749009903 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 696749009904 Helix-turn-helix domains; Region: HTH; cl00088 696749009905 Zeta toxin; Region: Zeta_toxin; pfam06414 696749009906 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 696749009907 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 696749009908 Staphylococcal nuclease homologues; Region: SNc; smart00318 696749009909 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 696749009910 Catalytic site; other site 696749009911 H-NS histone family; Region: Histone_HNS; pfam00816 696749009912 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 696749009913 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 696749009914 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696749009915 Active Sites [active] 696749009916 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696749009917 Active Sites [active] 696749009918 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 696749009919 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 696749009920 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749009921 P-loop; other site 696749009922 Magnesium ion binding site [ion binding]; other site 696749009923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 696749009924 Magnesium ion binding site [ion binding]; other site 696749009925 ParB-like partition proteins; Region: parB_part; TIGR00180 696749009926 ParB-like nuclease domain; Region: ParBc; cl02129 696749009927 KorB domain; Region: KorB; pfam08535 696749009928 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 696749009929 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 696749009930 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696749009931 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696749009932 N-terminal plug; other site 696749009933 ligand-binding site [chemical binding]; other site