-- dump date 20120504_131640 -- class Genbank::CDS -- table cds_note -- id note YP_002323944.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002323945.1 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog) YP_002323946.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002323947.1 [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit YP_002323948.1 [C] COG3783 Soluble cytochrome b562 YP_002323949.1 [S] COG0586 Uncharacterized membrane-associated protein YP_002323950.1 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_002323954.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002323955.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002323956.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002323957.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002323960.1 [O] COG0625 glutathione S-transferase YP_002323961.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002323963.1 [R] COG0733 Na+-dependent transporters of the SNF family YP_002323964.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002323965.1 [J] COG0144 tRNA and rRNA cytosine-C5-methylases YP_002323966.1 [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN YP_002323967.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002323969.1 [R] COG0730 Predicted permeases YP_002323970.1 [K] COG0583 transcriptional regulator YP_002323971.1 [R] COG2252 Permeases YP_002323972.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002323973.1 [K] COG1309 transcriptional regulator YP_002323974.1 [M] COG0845 Membrane-fusion protein YP_002323975.1 [V] COG0841 Cation/multidrug efflux pump YP_002323977.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002323979.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002323980.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002323981.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002323982.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_002323983.1 [K] COG0583 transcriptional regulator YP_002323985.1 [KE] COG1167 transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002323986.1 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_002323987.1 [L] COG2818 3-methyladenine DNA glycosylase YP_002323989.1 [M] COG0739 Membrane proteins related to metalloendopeptidases YP_002323990.1 [L] COG0177 Predicted EndoIII-related endonuclease YP_002323991.1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_002323992.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002323993.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002323994.1 [S] COG2983 Uncharacterized conserved protein YP_002323995.1 [G] COG2133 glucose/sorbosone dehydrogenases YP_002323996.1 [L] COG2812 DNA polymerase III, gamma/tau subunits YP_002323997.1 [P] COG2116 Formate/nitrite family of transporters YP_002323999.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002324001.1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_002324002.1 [Q] COG1335 amidases related to nicotinamidase YP_002324003.1 [P] COG0798 Arsenite efflux pump ACR3 and related permeases YP_002324004.1 [V] COG0534 Na+-driven multidrug efflux pump YP_002324005.1 [S] COG1683 Uncharacterized conserved protein YP_002324006.1 [ER] COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins YP_002324007.1 [K] COG1414 transcriptional regulator YP_002324008.1 [E] COG0346 Lactoylglutathione lyase and related lyases YP_002324009.1 [O] COG0625 glutathione S-transferase YP_002324010.1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) YP_002324011.1 [E] COG0833 amino acid transporters YP_002324013.1 [R] COG0523 GTPases (G3E family) YP_002324014.1 [I] COG1835 Predicted acyltransferases YP_002324015.1 [K] COG2188 transcriptional regulators YP_002324016.1 [S] COG3758 Uncharacterized protein conserved in bacteria YP_002324017.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002324018.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002324019.1 [E] COG0833 amino acid transporters YP_002324020.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002324021.1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family YP_002324022.1 [S] COG4805 Uncharacterized protein conserved in bacteria YP_002324023.1 [R] COG0546 Predicted phosphatases YP_002324024.1 [M] COG0796 glutamate racemase YP_002324026.1 [L] COG0270 Site-specific DNA methylase YP_002324027.1 [Z] COG5059 Kinesin-like protein YP_002324029.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002324030.1 [M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002324031.1 [I] COG1267 phosphatidylglycerophosphatase A and related proteins YP_002324033.1 [R] COG2144 Selenophosphate synthetase-related proteins YP_002324034.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002324035.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002324036.1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002324038.1 [E] COG0560 phosphoserine phosphatase YP_002324040.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324041.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002324042.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002324043.1 [P] COG2897 Rhodanese-related sulfurtransferase YP_002324044.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002324045.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324046.1 [T] COG0642 Signal transduction histidine kinase YP_002324047.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002324048.1 [K] COG1309 transcriptional regulator YP_002324049.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324050.1 [V] COG0534 Na+-driven multidrug efflux pump YP_002324051.1 catalyzes the transfer of an amino moiety YP_002324052.1 [S] COG2733 Predicted membrane protein YP_002324053.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324054.1 [S] COG3803 Uncharacterized protein conserved in bacteria YP_002324055.1 [H] COG2918 gamma-glutamylcysteine synthetase YP_002324056.1 [O] COG1495 Disulfide bond formation protein DsbB YP_002324057.1 [S] COG3501 Uncharacterized protein conserved in bacteria YP_002324058.1 [M] COG1388 FOG: LysM repeat YP_002324064.1 [R] COG3150 Predicted esterase YP_002324065.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002324066.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002324067.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_002324068.1 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_002324069.1 [M] COG3248 Nucleoside-binding outer membrane protein YP_002324070.1 [R] COG2252 Permeases YP_002324071.1 [R] COG2351 transthyretin-like protein YP_002324072.1 [S] COG3195 Uncharacterized protein conserved in bacteria YP_002324073.1 [G] COG0726 Predicted xylanase/chitin deacetylase YP_002324077.1 [O] COG0785 Cytochrome c biogenesis protein YP_002324078.1 [I] COG0657 Esterase/lipase YP_002324079.1 [S] COG4731 Uncharacterized protein conserved in bacteria YP_002324080.1 [P] COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_002324081.1 [L] COG0708 Exonuclease III YP_002324082.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002324083.1 [P] COG4771 outer membrane receptor for ferrienterochelin and colicins YP_002324084.1 [S] COG5515 Uncharacterized conserved small protein YP_002324085.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002324086.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002324087.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002324088.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002324089.1 [M] COG1589 Cell division septal protein YP_002324090.1 [D] COG0849 Actin-like ATPase involved in cell division YP_002324091.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002324092.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002324094.1 [M] COG0739 Membrane proteins related to metalloendopeptidases YP_002324095.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002324096.1 [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_002324098.1 [S] COG2119 Predicted membrane protein YP_002324099.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002324100.1 [C] COG0426 Uncharacterized flavoproteins YP_002324101.1 [R] COG0727 Predicted Fe-S-cluster oxidoreductase YP_002324102.1 [R] COG0517 FOG: CBS domain YP_002324103.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002324104.1 [L] COG0608 Single-stranded DNA-specific exonuclease YP_002324106.1 [J] COG1186 protein chain release factor B YP_002324107.1 [K] COG0640 Predicted transcriptional regulators YP_002324108.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002324109.1 [M] COG1519 3-deoxy-D-manno-octulosonic-acid transferase YP_002324110.1 [M] COG3264 Small-conductance mechanosensitive channel YP_002324111.1 [S] COG3152 Predicted membrane protein YP_002324113.1 [I] COG0365 acyl-coenzyme A synthetases/AMP-(fatty) acid ligases YP_002324114.1 [Q] COG1535 Isochorismate hydrolase YP_002324115.1 [K] COG1522 transcriptional regulators YP_002324116.1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_002324117.1 [R] COG0431 Predicted flavoprotein YP_002324118.1 [T] COG0784 FOG: CheY-like receiver YP_002324120.1 [ER] COG0591 Na+/proline symporter YP_002324121.1 [S] COG3162 Predicted membrane protein YP_002324122.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_002324123.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002324124.1 [M] COG1292 Choline-glycine betaine transporter YP_002324126.1 [T] COG2199 FOG: GGDEF domain YP_002324127.1 [J] COG0441 Threonyl-tRNA synthetase YP_002324128.1 [K] COG1309 transcriptional regulator YP_002324129.1 [R] COG1064 Zn-dependent alcohol dehydrogenases YP_002324130.1 [S] COG3759 Predicted membrane protein YP_002324131.1 [K] COG1309 transcriptional regulator YP_002324132.1 [K] COG0819 transcription activator YP_002324133.1 [P] COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_002324134.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324135.1 [J] COG0238 ribosomal protein S18 YP_002324136.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324137.1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) YP_002324138.1 [K] COG1396 Predicted transcriptional regulators YP_002324139.1 [E] COG0531 amino acid transporters YP_002324140.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002324141.1 [E] COG4992 Ornithine/acetylornithine aminotransferase YP_002324142.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002324143.1 [K] COG0583 transcriptional regulator YP_002324144.1 [Q] COG1335 amidases related to nicotinamidase YP_002324145.1 [R] COG1741 Pirin-related protein YP_002324146.1 [R] COG2907 Predicted NAD/FAD-binding protein YP_002324148.1 [S] COG3791 Uncharacterized conserved protein YP_002324150.1 [L] COG2189 Adenine specific DNA methylase Mod YP_002324154.1 [K] COG2378 Predicted transcriptional regulator YP_002324155.1 [V] COG1401 GTPase subunit of restriction endonuclease YP_002324156.1 [V] COG4268 McrBC 5-methylcytosine restriction system component YP_002324158.1 [S] COG3755 Uncharacterized protein conserved in bacteria YP_002324162.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002324163.1 [K] COG0583 transcriptional regulator YP_002324164.1 [M] COG0845 Membrane-fusion protein YP_002324165.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324166.1 [K] COG1309 transcriptional regulator YP_002324169.1 [L] COG0582 Integrase YP_002324174.1 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily YP_002324177.1 [K] COG1396 Predicted transcriptional regulators YP_002324178.1 [K] COG1396 Predicted transcriptional regulators YP_002324180.1 [K] COG1522 transcriptional regulators YP_002324181.1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) YP_002324182.1 [S] COG4541 Predicted membrane protein YP_002324183.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324184.1 [K] COG0583 transcriptional regulator YP_002324185.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324186.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324187.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324188.1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase YP_002324189.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324190.1 [K] COG1309 transcriptional regulator YP_002324191.1 [S] COG2128 Uncharacterized conserved protein YP_002324192.1 [K] COG1733 Predicted transcriptional regulators YP_002324194.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324195.1 [K] COG1733 Predicted transcriptional regulators YP_002324196.1 [R] COG2249 NADPH-quinone reductase (modulator of drug activity B) YP_002324197.1 [T] COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain YP_002324198.1 [J] COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_002324199.1 [P] COG3158 K+ transporter YP_002324200.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324201.1 [F] COG1864 DNA/RNA endonuclease G, NUC1 YP_002324202.1 [E] COG1280 threonine efflux protein YP_002324205.1 [G] COG0580 glycerol uptake facilitator and related permeases (Major Intrinsic protein Family) YP_002324206.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324208.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002324209.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_002324210.1 [S] COG3326 Predicted membrane protein YP_002324211.1 [S] COG3671 Predicted membrane protein YP_002324212.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324213.1 [K] COG1396 Predicted transcriptional regulators YP_002324214.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002324216.1 [S] COG3152 Predicted membrane protein YP_002324217.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002324218.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_002324220.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002324221.1 [C] COG0427 acetyl-CoA hydrolase YP_002324222.1 [T] COG0642 Signal transduction histidine kinase YP_002324223.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002324224.1 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs YP_002324225.1 [P] COG0288 Carbonic anhydrase YP_002324226.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324227.1 [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases YP_002324228.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002324232.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324233.1 [MU] COG1538 outer membrane protein YP_002324234.1 [M] COG0845 Membrane-fusion protein YP_002324235.1 [V] COG0841 Cation/multidrug efflux pump YP_002324236.1 [P] COG1230 Co/Zn/Cd efflux system component YP_002324239.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324240.1 [E] COG0833 amino acid transporters YP_002324241.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002324243.1 [P] COG1840 ABC-type Fe3+ transport system, periplasmic component YP_002324244.1 [M] COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_002324245.1 [D] COG3116 Cell division protein YP_002324246.1 [M] COG0744 Membrane carboxypeptidase (penicillin-binding protein) YP_002324247.1 [M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase YP_002324248.1 [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase YP_002324250.1 [QR] COG0500 SAM-dependent methyltransferases YP_002324251.1 [M] COG0744 Membrane carboxypeptidase (penicillin-binding protein) YP_002324252.1 [E] COG4820 Ethanolamine utilization protein, possible chaperonin YP_002324253.1 [NU] COG3166 Tfp pilus assembly protein PilN YP_002324254.1 [NU] COG3167 Tfp pilus assembly protein PilO YP_002324255.1 [NU] COG3168 Tfp pilus assembly protein PilP YP_002324256.1 [NU] COG1450 Type II secretory pathway, component PulD YP_002324257.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002324258.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002324260.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_002324261.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002324262.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002324263.1 [S] COG1704 Uncharacterized conserved protein YP_002324264.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324265.1 [S] COG3762 Predicted membrane protein YP_002324266.1 [NU] COG4968 Tfp pilus assembly protein PilE YP_002324267.1 [M] COG3307 Lipid A core - O-antigen ligase and related enzymes YP_002324268.1 [S] COG1633 Uncharacterized conserved protein YP_002324269.1 [P] COG2906 Bacterioferritin-associated ferredoxin YP_002324270.1 [J] COG0251 translation initiation inhibitor, yjgF family YP_002324271.1 [TK] COG0317 guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002324272.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002324273.1 Essential for recycling GMP and indirectly, cGMP YP_002324274.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002324275.1 [NU] COG4970 Tfp pilus assembly protein FimT YP_002324276.1 [NU] COG4966 Tfp pilus assembly protein PilW YP_002324278.1 [NU] COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 YP_002324279.1 [NU] COG2165 Type II secretory pathway, pseudopilin PulG YP_002324280.1 [NU] COG2165 Type II secretory pathway, pseudopilin PulG YP_002324281.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002324282.1 Essential for efficient processing of 16S rRNA YP_002324283.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002324284.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002324285.1 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold YP_002324286.1 acts as a molecular chaperone to fold and export lipase A YP_002324287.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002324288.1 [R] COG0730 Predicted permeases YP_002324289.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324290.1 [R] COG2962 Predicted permeases YP_002324291.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324292.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002324293.1 [C] COG0277 FAD/FMN-containing dehydrogenases YP_002324295.1 [S] COG1359 Uncharacterized conserved protein YP_002324296.1 [R] COG2249 NADPH-quinone reductase (modulator of drug activity B) YP_002324298.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324299.1 [S] COG1289 Predicted membrane protein YP_002324300.1 [P] COG2032 Cu/Zn superoxide dismutase YP_002324301.1 [R] COG0628 Predicted permease YP_002324302.1 [D] COG1192 ATPases involved in chromosome partitioning YP_002324303.1 [F] COG4741 Predicted secreted endonuclease distantly related to archaeal Holliday junction resolvase YP_002324306.1 [QR] COG0500 SAM-dependent methyltransferases YP_002324307.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324308.1 [E] COG0531 amino acid transporters YP_002324309.1 [E] COG0334 glutamate dehydrogenase/leucine dehydrogenase YP_002324310.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_002324311.1 [E] COG3138 Arginine/ornithine N-succinyltransferase beta subunit YP_002324312.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002324313.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_002324314.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002324315.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324317.1 [O] COG1404 Subtilisin-like serine proteases YP_002324320.1 [K] COG0583 transcriptional regulator YP_002324321.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324322.1 [S] COG2350 Uncharacterized protein conserved in bacteria YP_002324323.1 [S] COG1479 Uncharacterized conserved protein YP_002324325.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002324326.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002324327.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324328.1 [R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif YP_002324329.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324330.1 [R] COG0517 FOG: CBS domain YP_002324331.1 [KT] COG1983 stress-responsive transcriptional regulator YP_002324333.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324335.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002324336.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002324337.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_002324338.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002324339.1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_002324340.1 [LKJ] COG0513 Superfamily II DNA and RNA helicases YP_002324342.1 [E] COG1126 ABC-type polar amino acid transport system, ATPase component YP_002324343.1 [Q] COG0767 ABC-type transport system involved in resistance to organic solvents, permease component YP_002324344.1 [Q] COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_002324345.1 [Q] COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component YP_002324347.1 [P] COG0598 Mg2+ and Co2+ transporters YP_002324348.1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein YP_002324349.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002324350.1 [R] COG1040 Predicted amidophosphoribosyltransferases YP_002324351.1 catalyzes branch migration in Holliday junction intermediates YP_002324352.1 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases YP_002324354.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002324355.1 [I] COG1946 acyl-CoA thioesterase YP_002324356.1 [C] COG1301 Na+/H+-dicarboxylate symporters YP_002324357.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002324358.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002324359.1 [K] COG1959 Predicted transcriptional regulator YP_002324360.1 [C] COG1017 Hemoglobin-like flavoprotein YP_002324361.1 [R] COG0433 Predicted ATPase YP_002324362.1 [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases YP_002324363.1 [F] COG0518 GMP synthase - glutamine amidotransferase domain YP_002324364.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002324365.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002324366.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002324367.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002324368.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002324369.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002324370.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002324371.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002324372.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002324373.1 one of the stabilizing components for the large ribosomal subunit YP_002324374.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002324375.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002324376.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002324377.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002324378.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002324379.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002324380.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002324381.1 binds 5S rRNA along with protein L5 and L25 YP_002324382.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002324383.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002324384.1 late assembly protein YP_002324385.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002324386.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002324387.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002324388.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002324389.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002324390.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002324391.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002324392.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002324393.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324394.1 [S] COG2938 Uncharacterized conserved protein YP_002324397.1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002324398.1 [Q] COG4664 TRAP-type mannitol/chloroaromatic compound transport system, large permease component YP_002324400.1 [R] COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain YP_002324401.1 [E] COG0339 Zn-dependent oligopeptidases YP_002324402.1 [K] COG1095 DNA-directed RNA polymerase, subunit E' YP_002324403.1 [E] COG0560 phosphoserine phosphatase YP_002324404.1 [U] COG3210 Large exoproteins involved in heme utilization or adhesion YP_002324405.1 [R] COG3560 Predicted oxidoreductase related to nitroreductase YP_002324407.1 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) YP_002324408.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324409.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324410.1 [S] COG1295 Predicted membrane protein YP_002324411.1 [R] COG0655 Multimeric flavodoxin WrbA YP_002324412.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_002324413.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324415.1 [M] COG0810 Periplasmic protein TonB, links inner and outer membranes YP_002324416.1 [R] COG0319 Predicted metal-dependent hydrolase YP_002324417.1 [T] COG1702 phosphate starvation-inducible protein PhoH, predicted ATPase YP_002324418.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002324419.1 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002324420.1 [J] COG3719 ribonuclease I YP_002324421.1 catalyzes the oxidation of malate to oxaloacetate YP_002324424.1 [O] COG3751 Predicted proline hydroxylase YP_002324425.1 [R] COG2961 protein involved in catabolism of external DNA YP_002324426.1 [I] COG1183 phosphatidylserine synthase YP_002324429.1 [S] COG3791 Uncharacterized conserved protein YP_002324431.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324432.1 [K] COG1309 transcriptional regulator YP_002324433.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324434.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324435.1 [I] COG0777 acetyl-CoA carboxylase beta subunit YP_002324436.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324437.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002324438.1 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) YP_002324440.1 [R] COG2969 Stringent starvation protein B YP_002324441.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002324442.1 [J] COG0103 ribosomal protein S9 YP_002324443.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002324444.1 [H] COG1995 Pyridoxal phosphate biosynthesis protein YP_002324445.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_002324446.1 [S] COG4731 Uncharacterized protein conserved in bacteria YP_002324447.1 [M] COG1346 effector of murein hydrolase YP_002324449.1 [R] COG1160 Predicted GTPases YP_002324450.1 [I] COG1502 phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_002324451.1 [R] COG1409 Predicted phosphohydrolases YP_002324452.1 [N] COG1360 Flagellar motor protein YP_002324453.1 [T] COG2199 FOG: GGDEF domain YP_002324454.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324456.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002324458.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324459.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002324460.1 [I] COG1607 acyl-CoA hydrolase YP_002324461.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324462.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002324463.1 [P] COG0607 Rhodanese-related sulfurtransferase YP_002324464.1 [E] COG0665 glycine/D-amino acid oxidases (deaminating) YP_002324466.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_002324467.1 [D] COG2917 Intracellular septation protein A YP_002324468.1 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family) YP_002324469.1 [S] COG3781 Predicted membrane protein YP_002324470.1 [L] COG2003 DNA repair proteins YP_002324471.1 [H] COG0452 phosphopantothenoylcysteine synthetase/decarboxylase YP_002324472.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002324473.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002324474.1 [U] COG1862 Preprotein translocase subunit YajC YP_002324475.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002324476.1 [S] COG1704 Uncharacterized conserved protein YP_002324478.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002324479.1 [T] COG0642 Signal transduction histidine kinase YP_002324480.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002324481.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002324482.1 [M] COG3660 Predicted nucleoside-diphosphate-sugar epimerase YP_002324484.1 [G] COG0726 Predicted xylanase/chitin deacetylase YP_002324485.1 [M] COG0463 glycosyltransferases involved in cell wall biogenesis YP_002324486.1 [M] COG0438 glycosyltransferase YP_002324487.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324491.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324492.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002324494.1 [H] COG4206 outer membrane cobalamin receptor protein YP_002324495.1 [I] COG1502 phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_002324497.1 [S] COG5455 Predicted integral membrane protein YP_002324498.1 [S] COG3223 Predicted membrane protein YP_002324499.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324500.1 [I] COG1960 acyl-CoA dehydrogenases YP_002324502.1 [T] COG0642 Signal transduction histidine kinase YP_002324503.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002324504.1 [S] COG0397 Uncharacterized conserved protein YP_002324505.1 [I] COG1398 Fatty-acid desaturase YP_002324506.1 [O] COG3187 Heat shock protein YP_002324507.1 [C] COG0584 glycerophosphoryl diester phosphodiesterase YP_002324508.1 [S] COG2096 Uncharacterized conserved protein YP_002324509.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002324510.1 [E] COG0135 phosphoribosylanthranilate isomerase YP_002324511.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002324512.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324513.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324514.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002324515.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324516.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002324517.1 [I] COG4799 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_002324518.1 [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase YP_002324519.1 [KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription YP_002324520.1 [T] COG2365 protein tyrosine/serine phosphatase YP_002324521.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002324522.1 [O] COG1225 Peroxiredoxin YP_002324523.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002324524.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324525.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324526.1 [R] COG1272 Predicted membrane protein, hemolysin III homolog YP_002324527.1 [QR] COG0500 SAM-dependent methyltransferases YP_002324528.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002324529.1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_002324531.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002324532.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002324533.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002324534.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324535.1 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_002324536.1 [M] COG3659 Carbohydrate-selective porin YP_002324538.1 [G] COG4993 glucose dehydrogenase YP_002324539.1 [P] COG0155 Sulfite reductase, beta subunit (hemoprotein) YP_002324540.1 [S] COG3749 Uncharacterized protein conserved in bacteria YP_002324541.1 [P] COG2076 Membrane transporters of cations and cationic drugs YP_002324542.1 [S] COG2764 Uncharacterized protein conserved in bacteria YP_002324543.1 [I] COG0183 acetyl-CoA acetyltransferase YP_002324544.1 [NU] COG4970 Tfp pilus assembly protein FimT YP_002324545.1 [N] COG1360 Flagellar motor protein YP_002324547.1 [S] COG1690 Uncharacterized conserved protein YP_002324548.1 [E] COG0531 amino acid transporters YP_002324549.1 [J] COG2813 16S RNA G1207 methylase RsmC YP_002324550.1 [P] COG0659 Sulfate permease and related transporters (MFS superfamily) YP_002324551.1 [J] COG0480 translation elongation factors (GTPases) YP_002324552.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002324553.1 [S] COG2105 Uncharacterized conserved protein YP_002324554.1 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase YP_002324555.1 [L] COG0266 Formamidopyrimidine-DNA glycosylase YP_002324556.1 [L] COG2094 3-methyladenine DNA glycosylase YP_002324557.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002324558.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002324559.1 [R] COG0679 Predicted permeases YP_002324560.1 [R] COG0790 FOG: TPR repeat, SEL1 subfamily YP_002324561.1 [O] COG1651 protein-disulfide isomerase YP_002324562.1 [R] COG0354 Predicted aminomethyltransferase related to GcvT YP_002324563.1 [S] COG3832 Uncharacterized conserved protein YP_002324564.1 [S] COG3189 Uncharacterized conserved protein YP_002324565.1 [P] COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism YP_002324566.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324567.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002324568.1 [P] COG3696 silver efflux pump YP_002324569.1 [M] COG0845 Membrane-fusion protein YP_002324571.1 [T] COG0784 FOG: CheY-like receiver YP_002324572.1 [T] COG0784 FOG: CheY-like receiver YP_002324573.1 [NT] COG0835 Chemotaxis signal transduction protein YP_002324574.1 [NT] COG0840 methyl-accepting chemotaxis protein YP_002324575.1 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases YP_002324577.1 [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases YP_002324578.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002324579.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002324580.1 [S] COG5510 Predicted small secreted protein YP_002324581.1 [S] COG3782 Uncharacterized protein conserved in bacteria YP_002324582.1 [S] COG2832 Uncharacterized protein conserved in bacteria YP_002324583.1 [S] COG1376 Uncharacterized protein conserved in bacteria YP_002324584.1 [K] COG1309 transcriptional regulator YP_002324585.1 [P] COG0369 Sulfite reductase, alpha subunit (flavoprotein) YP_002324587.1 [S] COG1289 Predicted membrane protein YP_002324588.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324589.1 [C] COG0778 nitroreductase YP_002324592.1 [E] COG1115 Na+/alanine symporter YP_002324593.1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_002324594.1 [E] COG0031 Cysteine synthase YP_002324595.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_002324596.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324597.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324599.1 [R] COG0693 intracellular protease/amidase YP_002324600.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002324601.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002324602.1 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit YP_002324603.1 functions in MreBCD complex in some organisms YP_002324604.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002324606.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002324607.1 [J] COG1530 ribonucleases G and E YP_002324609.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324610.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002324611.1 catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity YP_002324612.1 [I] COG2067 Long-chain fatty acid transport protein YP_002324613.1 [R] COG2249 NADPH-quinone reductase (modulator of drug activity B) YP_002324614.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324615.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324616.1 [I] COG3239 Fatty acid desaturase YP_002324617.1 [K] COG3327 phenylacetic acid-responsive transcriptional repressor YP_002324618.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002324619.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002324620.1 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_002324621.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_002324622.1 [E] COG0833 amino acid transporters YP_002324624.1 [S] COG2828 Uncharacterized protein conserved in bacteria YP_002324625.1 [H] COG0142 Geranylgeranyl pyrophosphate synthase YP_002324626.1 [S] COG2315 Uncharacterized protein conserved in bacteria YP_002324627.1 [S] COG2315 Uncharacterized protein conserved in bacteria YP_002324628.1 [S] COG2268 Uncharacterized protein conserved in bacteria YP_002324629.1 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity YP_002324630.1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_002324631.1 [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002324632.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324634.1 [R] COG2194 Predicted membrane-associated, metal-dependent hydrolase YP_002324635.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002324636.1 [T] COG0642 Signal transduction histidine kinase YP_002324637.1 [P] COG0004 Ammonia permease YP_002324638.1 [K] COG0583 transcriptional regulator YP_002324639.1 [R] COG0679 Predicted permeases YP_002324640.1 [O] COG1076 DnaJ-domain-containing proteins 1 YP_002324642.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002324644.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324645.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324646.1 [S] COG0393 Uncharacterized conserved protein YP_002324647.1 [S] COG0393 Uncharacterized conserved protein YP_002324648.1 [MU] COG1538 outer membrane protein YP_002324649.1 [V] COG0841 Cation/multidrug efflux pump YP_002324650.1 [M] COG0845 Membrane-fusion protein YP_002324651.1 [I] COG0671 Membrane-associated phospholipid phosphatase YP_002324652.1 [L] COG4389 Site-specific recombinase YP_002324653.1 [H] COG0142 Geranylgeranyl pyrophosphate synthase YP_002324654.1 [J] COG0261 ribosomal protein L21 YP_002324655.1 involved in the peptidyltransferase reaction during translation YP_002324656.1 [M] COG2834 outer membrane lipoprotein-sorting protein YP_002324657.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324658.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002324659.1 [H] COG2243 Precorrin-2 methylase YP_002324660.1 [J] COG0566 rRNA methylases YP_002324661.1 [K] COG1733 Predicted transcriptional regulators YP_002324662.1 [R] COG0655 Multimeric flavodoxin WrbA YP_002324663.1 [E] COG1113 gamma-aminobutyrate permease and related permeases YP_002324664.1 [C] COG0371 glycerol dehydrogenase and related enzymes YP_002324666.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002324667.1 [S] COG2921 Uncharacterized conserved protein YP_002324668.1 [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit YP_002324670.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324671.1 [R] COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA YP_002324672.1 [P] COG0607 Rhodanese-related sulfurtransferase YP_002324673.1 [R] COG3313 Predicted Fe-S protein YP_002324674.1 [C] COG0372 Citrate synthase YP_002324675.1 [C] COG2009 succinate dehydrogenase/fumarate reductase, cytochrome b subunit YP_002324676.1 [C] COG2142 succinate dehydrogenase, hydrophobic anchor subunit YP_002324677.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002324678.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002324680.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002324681.1 [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_002324682.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002324683.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002324684.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002324688.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002324689.1 [S] COG2354 Uncharacterized protein conserved in bacteria YP_002324690.1 [R] COG2321 Predicted metalloprotease YP_002324691.1 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters YP_002324692.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324693.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324694.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324695.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324697.1 [M] COG2843 enzyme of poly-gamma-glutamate biosynthesis (capsule formation) YP_002324699.1 [L] COG0350 methylated DNA-protein cysteine methyltransferase YP_002324700.1 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_002324701.1 [R] COG0110 acetyltransferase (isoleucine patch superfamily) YP_002324702.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002324703.1 [I] COG0439 Biotin carboxylase YP_002324704.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002324705.1 [NT] COG0840 methyl-accepting chemotaxis protein YP_002324706.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324707.1 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein YP_002324708.1 [J] COG0293 23S rRNA methylase YP_002324709.1 [O] COG0464 ATPases of the AAA+ class YP_002324710.1 [H] COG0294 Dihydropteroate synthase and related enzymes YP_002324713.1 [P] COG3540 phosphodiesterase/alkaline phosphatase D YP_002324714.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002324715.1 [J] COG2264 ribosomal protein L11 methylase YP_002324717.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324718.1 [C] COG1069 Ribulose kinase YP_002324719.1 [C] COG0578 glycerol-3-phosphate dehydrogenase YP_002324720.1 [C] COG0578 glycerol-3-phosphate dehydrogenase YP_002324721.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_002324722.1 [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_002324723.1 [R] COG1409 Predicted phosphohydrolases YP_002324724.1 [MU] COG3468 Type V secretory pathway, adhesin AidA YP_002324725.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002324726.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002324727.1 [M] COG0818 Diacylglycerol kinase YP_002324728.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002324729.1 [C] COG0584 glycerophosphoryl diester phosphodiesterase YP_002324730.1 [V] COG0841 Cation/multidrug efflux pump YP_002324731.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324732.1 metalloprotease YP_002324733.1 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002324734.1 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_002324736.1 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002324737.1 [K] COG0782 transcription elongation factor YP_002324739.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324744.1 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase YP_002324745.1 [C] COG0778 nitroreductase YP_002324746.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324747.1 [K] COG1309 transcriptional regulator YP_002324748.1 [G] COG1929 glycerate kinase YP_002324749.1 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_002324750.1 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity YP_002324751.1 [S] COG3339 Uncharacterized conserved protein YP_002324752.1 [HE] COG0111 phosphoglycerate dehydrogenase and related dehydrogenases YP_002324753.1 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases YP_002324754.1 [S] COG4395 Uncharacterized protein conserved in bacteria YP_002324756.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002324758.1 [E] COG0531 amino acid transporters YP_002324760.1 [E] COG1166 Arginine decarboxylase (spermidine biosynthesis) YP_002324761.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002324762.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002324763.1 [E] COG1280 threonine efflux protein YP_002324764.1 [L] COG0582 Integrase YP_002324765.1 [C] COG2086 Electron transfer flavoprotein, beta subunit YP_002324766.1 [C] COG2025 Electron transfer flavoprotein, alpha subunit YP_002324767.1 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit YP_002324768.1 [M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002324769.1 [S] COG2246 Predicted membrane protein YP_002324770.1 [M] COG0463 glycosyltransferases involved in cell wall biogenesis YP_002324771.1 [S] COG3394 Uncharacterized protein conserved in bacteria YP_002324772.1 [V] COG0842 ABC-type multidrug transport system, permease component YP_002324773.1 [V] COG0842 ABC-type multidrug transport system, permease component YP_002324774.1 [V] COG1566 multidrug resistance efflux pump YP_002324775.1 [MU] COG1538 outer membrane protein YP_002324777.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002324780.1 [S] COG1671 Uncharacterized protein conserved in bacteria YP_002324781.1 [R] COG2962 Predicted permeases YP_002324782.1 [M] COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_002324783.1 [P] COG1135 ABC-type metal ion transport system, ATPase component YP_002324784.1 [R] COG0658 Predicted membrane metal-binding protein YP_002324785.1 [OU] COG0616 Periplasmic serine proteases (ClpP class) YP_002324786.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002324787.1 [J] COG0223 methionyl-tRNA formyltransferase YP_002324788.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002324789.1 [R] COG0628 Predicted permease YP_002324790.1 [L] COG0593 ATPase involved in DNA replication initiation YP_002324794.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_002324795.1 [J] COG0566 rRNA methylases YP_002324796.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002324798.1 [M] COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_002324799.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002324800.1 [D] COG4942 Membrane-bound metallopeptidase YP_002324801.1 [U] COG0848 biopolymer transport protein YP_002324802.1 [U] COG0811 biopolymer transport proteins YP_002324803.1 [R] COG0824 Predicted thioesterase YP_002324804.1 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_002324805.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002324806.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002324807.1 dGTPase family type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002324808.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002324809.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324811.1 [S] COG3323 Uncharacterized protein conserved in bacteria YP_002324812.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002324813.1 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase YP_002324814.1 [S] COG2340 Uncharacterized protein with SCP/PR1 domains YP_002324815.1 [O] COG1225 Peroxiredoxin YP_002324816.1 [R] COG2102 Predicted ATPases of PP-loop superfamily YP_002324818.1 [R] COG0603 Predicted PP-loop superfamily ATPase YP_002324819.1 [O] COG0602 Organic radical activating enzymes YP_002324820.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002324822.1 [K] COG0583 transcriptional regulator YP_002324823.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002324824.1 [P] COG1178 ABC-type Fe3+ transport system, permease component YP_002324825.1 [P] COG1178 ABC-type Fe3+ transport system, permease component YP_002324826.1 [R] COG3545 Predicted esterase of the alpha/beta hydrolase fold YP_002324827.1 [P] COG1613 ABC-type sulfate transport system, periplasmic component YP_002324828.1 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_002324829.1 [R] COG1559 Predicted periplasmic solute-binding protein YP_002324830.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002324831.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002324832.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002324833.1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002324834.1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002324835.1 [R] COG0824 Predicted thioesterase YP_002324836.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002324837.1 [U] COG0681 Signal peptidase I YP_002324838.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324839.1 [K] COG0571 dsRNA-specific ribonuclease YP_002324840.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002324842.1 [L] COG1381 Recombinational DNA repair protein (RecF pathway) YP_002324843.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002324844.1 [FJ] COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA YP_002324845.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002324847.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002324848.1 [S] COG3791 Uncharacterized conserved protein YP_002324849.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002324850.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002324852.1 [T] COG2199 FOG: GGDEF domain YP_002324853.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324854.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002324855.1 [M] COG3040 Bacterial lipocalin YP_002324856.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002324857.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_002324860.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002324861.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002324862.1 [E] COG0560 phosphoserine phosphatase YP_002324863.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324864.1 [J] COG0042 tRNA-dihydrouridine synthase YP_002324865.1 [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_002324866.1 [S] COG1814 Uncharacterized membrane protein YP_002324868.1 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase YP_002324873.1 [L] COG0415 Deoxyribodipyrimidine photolyase YP_002324874.1 [O] COG0545 peptidyl-prolyl cis-trans isomerases 1 YP_002324875.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002324876.1 [M] COG1686 D-alanyl-D-alanine carboxypeptidase YP_002324877.1 [R] COG3975 Predicted protease with the C-terminal PDZ domain YP_002324878.1 [C] COG2838 Monomeric isocitrate dehydrogenase YP_002324879.1 [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002324880.1 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase YP_002324883.1 [G] COG2814 Arabinose efflux permease YP_002324884.1 [K] COG0583 transcriptional regulator YP_002324885.1 [C] COG1301 Na+/H+-dicarboxylate symporters YP_002324886.1 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog YP_002324887.1 [R] COG0612 Predicted Zn-dependent peptidases YP_002324888.1 [R] COG0612 Predicted Zn-dependent peptidases YP_002324891.1 [S] COG5607 Uncharacterized conserved protein YP_002324892.1 [S] COG4323 Predicted membrane protein YP_002324893.1 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair YP_002324894.1 Yersinia-type; [R] COG1203 Predicted helicases YP_002324895.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324896.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324897.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324903.1 [H] COG0352 Thiamine monophosphate synthase YP_002324904.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002324906.1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific YP_002324907.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_002324908.1 [R] COG0628 Predicted permease YP_002324909.1 [K] COG1309 transcriptional regulator YP_002324910.1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002324911.1 [I] COG3239 Fatty acid desaturase YP_002324912.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324913.1 [K] COG1309 transcriptional regulator YP_002324914.1 [S] COG2968 Uncharacterized conserved protein YP_002324915.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_002324916.1 [E] COG0076 glutamate decarboxylase and related PLP-dependent proteins YP_002324917.1 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_002324918.1 [K] COG1522 transcriptional regulators YP_002324919.1 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_002324920.1 [E] COG0531 amino acid transporters YP_002324921.1 [P] COG0226 ABC-type phosphate transport system, periplasmic component YP_002324922.1 [O] COG0555 ABC-type sulfate transport system, permease component YP_002324923.1 [P] COG0573 ABC-type phosphate transport system, permease component YP_002324924.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002324925.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002324926.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324927.1 [S] COG3647 Predicted membrane protein YP_002324928.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002324929.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002324930.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002324931.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002324932.1 [M] COG1043 acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase YP_002324933.1 [M] COG1686 D-alanyl-D-alanine carboxypeptidase YP_002324936.1 [R] COG0496 Predicted acid phosphatase YP_002324937.1 [M] COG0739 Membrane proteins related to metalloendopeptidases YP_002324938.1 [K] COG0583 transcriptional regulator YP_002324939.1 [O] COG0466 ATP-dependent Lon protease, bacterial type YP_002324940.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002324941.1 [E] COG0346 Lactoylglutathione lyase and related lyases YP_002324942.1 [R] COG0385 Predicted Na+-dependent transporter YP_002324943.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002324944.1 [T] COG2200 FOG: EAL domain YP_002324945.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324946.1 [E] COG1509 lysine 2,3-aminomutase YP_002324947.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002324948.1 [T] COG1966 Carbon starvation protein, predicted membrane protein YP_002324949.1 [S] COG2879 Uncharacterized small protein YP_002324951.1 [H] COG0303 molybdopterin biosynthesis enzyme YP_002324953.1 [K] COG1309 transcriptional regulator YP_002324958.1 [R] COG1741 Pirin-related protein YP_002324959.1 catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine YP_002324960.1 [S] COG2964 Uncharacterized protein conserved in bacteria YP_002324961.1 [P] COG2375 Siderophore-interacting protein YP_002324962.1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins YP_002324963.1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins YP_002324966.1 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component YP_002324967.1 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component YP_002324968.1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component YP_002324969.1 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_002324970.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002324971.1 [Q] COG3486 lysine/ornithine N-monooxygenase YP_002324972.1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins YP_002324973.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_002324974.1 [Q] COG1335 amidases related to nicotinamidase YP_002324975.1 catalyzes the formation of histamine from L-histidine YP_002324977.1 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components YP_002324978.1 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components YP_002324979.1 [Q] COG3208 Predicted thioesterase involved in non-ribosomal peptide biosynthesis YP_002324980.1 [Q] COG2977 phosphopantetheinyl transferase component of siderophore synthetase YP_002324981.1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I YP_002324982.1 [S] COG1376 Uncharacterized protein conserved in bacteria YP_002324983.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002324984.1 [S] COG3739 Uncharacterized integral membrane protein YP_002324985.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324986.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002324987.1 [V] COG1680 beta-lactamase class C and other penicillin binding proteins YP_002324988.1 [H] COG0302 GTP cyclohydrolase I YP_002324989.1 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs YP_002324990.1 [C] COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs YP_002324991.1 [O] COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family YP_002324992.1 [S] COG2840 Uncharacterized protein conserved in bacteria YP_002324993.1 [E] COG0134 Indole-3-glycerol phosphate synthase YP_002324994.1 [E] COG0134 Indole-3-glycerol phosphate synthase YP_002324995.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002324996.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002324997.1 [E] COG0308 aminopeptidase N YP_002324998.1 [EF] COG0505 Carbamoylphosphate synthase small subunit YP_002324999.1 [E] COG0006 Xaa-Pro aminopeptidase YP_002325000.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325001.1 [E] COG0174 glutamine synthetase YP_002325002.1 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase) YP_002325003.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_002325004.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325007.1 [P] COG0605 Superoxide dismutase YP_002325008.1 [S] COG0327 Uncharacterized conserved protein YP_002325009.1 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002325010.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_002325011.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_002325012.1 [T] COG4943 Predicted signal transduction protein containing sensor and EAL domains YP_002325013.1 [S] COG1385 Uncharacterized protein conserved in bacteria YP_002325014.1 [E] COG0685 5,10-methylenetetrahydrofolate reductase YP_002325015.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_002325017.1 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit YP_002325018.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002325019.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002325020.1 catalyzes the conversion of NADPH to NADH YP_002325022.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325023.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325024.1 [M] COG3047 outer membrane protein W YP_002325025.1 [E] COG0006 Xaa-Pro aminopeptidase YP_002325026.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002325027.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002325028.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325029.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325030.1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) YP_002325031.1 [S] COG4539 Predicted membrane protein YP_002325032.1 [M] COG0797 lipoproteins YP_002325033.1 [M] COG2951 Membrane-bound lytic murein transglycosylase B YP_002325034.1 [D] COG0772 Bacterial cell division membrane protein YP_002325036.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002325037.1 [V] COG0842 ABC-type multidrug transport system, permease component YP_002325038.1 [V] COG1131 ABC-type multidrug transport system, ATPase component YP_002325040.1 [L] COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases YP_002325041.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325043.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002325044.1 [MU] COG1538 outer membrane protein YP_002325045.1 [V] COG0841 Cation/multidrug efflux pump YP_002325046.1 [M] COG0845 Membrane-fusion protein YP_002325047.1 [K] COG0583 transcriptional regulator YP_002325048.1 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_002325049.1 [E] COG0765 ABC-type amino acid transport system, permease component YP_002325050.1 [E] COG0765 ABC-type amino acid transport system, permease component YP_002325051.1 [E] COG1126 ABC-type polar amino acid transport system, ATPase component YP_002325052.1 [P] COG2076 Membrane transporters of cations and cationic drugs YP_002325053.1 [C] COG1145 Ferredoxin YP_002325054.1 [O] COG0826 Collagenase and related proteases YP_002325055.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002325056.1 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog YP_002325057.1 [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_002325058.1 [S] COG1720 Uncharacterized conserved protein YP_002325059.1 [S] COG3174 Predicted membrane protein YP_002325060.1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF YP_002325061.1 [S] COG3111 Uncharacterized conserved protein YP_002325062.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002325063.1 [T] COG0642 Signal transduction histidine kinase YP_002325065.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002325066.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325067.1 [M] COG5009 Membrane carboxypeptidase/penicillin-binding protein YP_002325068.1 catalyzes the phosphorylation of NAD to NADP YP_002325069.1 [S] COG3139 Uncharacterized protein conserved in bacteria YP_002325070.1 [E] COG0547 Anthranilate phosphoribosyltransferase YP_002325071.1 involved in the transport of C4-dicarboxylates across the membrane YP_002325072.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325073.1 [R] COG2819 Predicted hydrolase of the alpha/beta superfamily YP_002325074.1 [E] COG1605 Chorismate mutase YP_002325075.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate and catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002325077.1 [E] COG0624 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases YP_002325078.1 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III YP_002325079.1 [R] COG2945 Predicted hydrolase of the alpha/beta superfamily YP_002325080.1 [S] COG3022 Uncharacterized protein conserved in bacteria YP_002325081.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002325082.1 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis YP_002325083.1 [S] COG2363 Uncharacterized small membrane protein YP_002325084.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002325086.1 [K] COG1278 Cold shock proteins YP_002325087.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_002325089.1 [C] COG0778 nitroreductase YP_002325090.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002325091.1 [T] COG2062 phosphohistidine phosphatase SixA YP_002325092.1 [U] COG3297 Type II secretory pathway, component PulL YP_002325094.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002325095.1 [R] COG1286 Uncharacterized membrane protein, required for colicin V production YP_002325096.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002325097.1 [O] COG0501 Zn-dependent protease with chaperone function YP_002325099.1 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases YP_002325100.1 [O] COG0501 Zn-dependent protease with chaperone function YP_002325101.1 [S] COG1610 Uncharacterized conserved protein YP_002325102.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002325103.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002325105.1 [R] COG2607 Predicted ATPase (AAA+ superfamily) YP_002325106.1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_002325107.1 [RTKL] COG0515 Serine/threonine protein kinase YP_002325108.1 [K] COG0583 transcriptional regulator YP_002325109.1 [E] COG4992 Ornithine/acetylornithine aminotransferase YP_002325110.1 [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002325111.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002325112.1 [E] COG0531 amino acid transporters YP_002325113.1 [S] COG3798 Uncharacterized protein conserved in bacteria YP_002325114.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325116.1 [S] COG2120 Uncharacterized proteins, LmbE homologs YP_002325117.1 [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases YP_002325118.1 [M] COG0463 glycosyltransferases involved in cell wall biogenesis YP_002325120.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325122.1 [E] COG1280 threonine efflux protein YP_002325123.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325124.1 [I] COG3243 poly(3-hydroxyalkanoate) synthetase YP_002325125.1 [E] COG0786 Na+/glutamate symporter YP_002325127.1 [K] COG0583 transcriptional regulator YP_002325128.1 [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_002325129.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325130.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325131.1 [R] COG2607 Predicted ATPase (AAA+ superfamily) YP_002325132.1 [K] COG2186 transcriptional regulators YP_002325134.1 [K] COG1309 transcriptional regulator YP_002325135.1 [S] COG5430 Uncharacterized secreted protein YP_002325137.1 [S] COG5430 Uncharacterized secreted protein YP_002325138.1 [NU] COG3121 P pilus assembly protein, chaperone PapD YP_002325139.1 [NU] COG3188 P pilus assembly protein, porin PapC YP_002325140.1 [S] COG5430 Uncharacterized secreted protein YP_002325144.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325145.1 [K] COG1309 transcriptional regulator YP_002325146.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325147.1 [S] COG2995 Uncharacterized paraquat-inducible protein A YP_002325148.1 [S] COG2995 Uncharacterized paraquat-inducible protein A YP_002325149.1 [R] COG3008 Paraquat-inducible protein B YP_002325150.1 [S] COG3009 Uncharacterized protein conserved in bacteria YP_002325151.1 [R] COG2351 transthyretin-like protein YP_002325152.1 [R] COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol YP_002325153.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002325154.1 [T] COG0642 Signal transduction histidine kinase YP_002325155.1 [M] COG3040 Bacterial lipocalin YP_002325156.1 [I] COG1398 Fatty-acid desaturase YP_002325157.1 [R] COG2907 Predicted NAD/FAD-binding protein YP_002325158.1 [S] COG3496 Uncharacterized conserved protein YP_002325159.1 [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases YP_002325160.1 [O] COG2020 protein-S-isoprenylcysteine methyltransferase YP_002325161.1 [QR] COG0500 SAM-dependent methyltransferases YP_002325162.1 [T] COG0642 Signal transduction histidine kinase YP_002325163.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002325166.1 [J] COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_002325167.1 [M] COG1794 Aspartate racemase YP_002325168.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325169.1 [G] COG2133 glucose/sorbosone dehydrogenases YP_002325170.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002325171.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325172.1 [K] COG1309 transcriptional regulator YP_002325173.1 [C] COG1301 Na+/H+-dicarboxylate symporters YP_002325175.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002325176.1 [E] COG0765 ABC-type amino acid transport system, permease component YP_002325177.1 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002325178.1 [P] COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen YP_002325179.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002325180.1 involved in de novo purine biosynthesis YP_002325181.1 [T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_002325183.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002325185.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002325187.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325188.1 [S] COG2308 Uncharacterized conserved protein YP_002325190.1 [E] COG1305 transglutaminase-like enzymes, cysteine proteases YP_002325191.1 [O] COG3484 Predicted proteasome-type protease YP_002325192.1 [M] COG0787 Alanine racemase YP_002325193.1 [L] COG0305 Replicative DNA helicase YP_002325194.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002325195.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002325196.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002325197.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002325198.1 [C] COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4 YP_002325199.1 [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 YP_002325200.1 [O] COG3278 Cbb3-type cytochrome oxidase, subunit 1 YP_002325201.1 [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 YP_002325202.1 [S] COG1714 Predicted membrane protein/domain YP_002325203.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002325204.1 [S] COG1806 Uncharacterized protein conserved in bacteria YP_002325205.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325206.1 [G] COG0726 Predicted xylanase/chitin deacetylase YP_002325207.1 [M] COG0463 glycosyltransferases involved in cell wall biogenesis YP_002325208.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325209.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002325210.1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_002325211.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325212.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325213.1 [K] COG0583 transcriptional regulator YP_002325214.1 [R] COG0693 intracellular protease/amidase YP_002325215.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002325216.1 [J] COG2813 16S RNA G1207 methylase RsmC YP_002325217.1 [E] COG1174 ABC-type proline/glycine betaine transport systems, permease component YP_002325218.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002325219.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325220.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325221.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325222.1 [I] COG0365 acyl-coenzyme A synthetases/AMP-(fatty) acid ligases YP_002325223.1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002325224.1 [H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 YP_002325225.1 [R] COG0661 Predicted unusual protein kinase YP_002325226.1 [H] COG1539 Dihydroneopterin aldolase YP_002325227.1 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_002325228.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002325229.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002325230.1 [P] COG2156 K+-transporting ATPase, c chain YP_002325231.1 [T] COG0642 Signal transduction histidine kinase YP_002325232.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002325233.1 [E] COG0174 glutamine synthetase YP_002325234.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325235.1 [H] COG2941 Ubiquinone biosynthesis protein COQ7 YP_002325236.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325237.1 [M] COG4775 outer membrane protein/protective antigen OMA87 YP_002325238.1 [S] COG2911 Uncharacterized protein conserved in bacteria YP_002325240.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002325242.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002325243.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325246.1 [K] COG0583 transcriptional regulator YP_002325247.1 [S] COG2707 Predicted membrane protein YP_002325249.1 [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002325250.1 [R] COG0456 acetyltransferases YP_002325251.1 [L] COG3077 DNA-damage-inducible protein J YP_002325252.1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific YP_002325253.1 [R] COG0802 Predicted ATPase or kinase YP_002325254.1 [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) YP_002325255.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002325256.1 [L] COG0629 Single-stranded DNA-binding protein YP_002325257.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325258.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_002325260.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_002325261.1 [O] COG0652 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_002325262.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002325264.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_002325265.1 [E] COG4302 Ethanolamine ammonia-lyase, small subunit YP_002325266.1 [E] COG4303 Ethanolamine ammonia-lyase, large subunit YP_002325267.1 [E] COG0531 amino acid transporters YP_002325268.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002325269.1 [QK] COG3284 transcriptional activator of acetoin/glycerol metabolism YP_002325270.1 [I] COG2267 Lysophospholipase YP_002325271.1 [C] COG0371 glycerol dehydrogenase and related enzymes YP_002325272.1 [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_002325273.1 [E] COG3232 5-carboxymethyl-2-hydroxymuconate isomerase YP_002325274.1 [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family YP_002325277.1 [E] COG0308 aminopeptidase N YP_002325278.1 [S] COG5430 Uncharacterized secreted protein YP_002325279.1 [NU] COG3121 P pilus assembly protein, chaperone PapD YP_002325280.1 [NU] COG3188 P pilus assembly protein, porin PapC YP_002325281.1 [S] COG5430 Uncharacterized secreted protein YP_002325282.1 [O] COG0625 glutathione S-transferase YP_002325283.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325284.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325285.1 catalyzes the interconversion of chorismate to prephenate YP_002325286.1 [K] COG1522 transcriptional regulators YP_002325288.1 [F] COG0563 Adenylate kinase and related kinases YP_002325291.1 [K] COG1309 transcriptional regulator YP_002325292.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325293.1 [H] COG4206 outer membrane cobalamin receptor protein YP_002325294.1 [M] COG0668 Small-conductance mechanosensitive channel YP_002325299.1 [R] COG3153 Predicted acetyltransferase YP_002325300.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325301.1 [M] COG3047 outer membrane protein W YP_002325304.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325305.1 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_002325306.1 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_002325309.1 [S] COG1714 Predicted membrane protein/domain YP_002325310.1 P-type ATPase involved in magnesium influx YP_002325311.1 [S] COG3174 Predicted membrane protein YP_002325312.1 [F] COG2233 Xanthine/uracil permeases YP_002325313.1 [K] COG1522 transcriptional regulators YP_002325314.1 [E] COG1280 threonine efflux protein YP_002325315.1 [G] COG0176 transaldolase YP_002325316.1 [K] COG0583 transcriptional regulator YP_002325317.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002325318.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002325319.1 [I] COG2030 acyl dehydratase YP_002325320.1 [V] COG1680 beta-lactamase class C and other penicillin binding proteins YP_002325321.1 [K] COG1309 transcriptional regulator YP_002325322.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325323.1 [U] COG0552 Signal recognition particle GTPase YP_002325324.1 [M] COG3511 phospholipase C YP_002325325.1 [R] COG0824 Predicted thioesterase YP_002325326.1 [C] COG1454 Alcohol dehydrogenase, class IV YP_002325327.1 [G] COG2706 3-carboxymuconate cyclase YP_002325328.1 [T] COG0394 protein-tyrosine-phosphatase YP_002325329.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002325330.1 [S] COG1434 Uncharacterized conserved protein YP_002325331.1 [I] COG2267 Lysophospholipase YP_002325332.1 [E] COG0069 glutamate synthase domain 2 YP_002325333.1 [S] COG3182 Uncharacterized iron-regulated membrane protein YP_002325335.1 [K] COG1309 transcriptional regulator YP_002325337.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325339.1 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) YP_002325340.1 [I] COG0511 Biotin carboxyl carrier protein YP_002325341.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002325342.1 [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair YP_002325343.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002325344.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002325345.1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002325346.1 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_002325347.1 [H] COG0746 molybdopterin-guanine dinucleotide biosynthesis protein A YP_002325348.1 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_002325349.1 [R] COG0535 Predicted Fe-S oxidoreductases YP_002325350.1 [H] COG0314 molybdopterin converting factor, large subunit YP_002325351.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002325352.1 [H] COG0303 molybdopterin biosynthesis enzyme YP_002325353.1 [K] COG1733 Predicted transcriptional regulators YP_002325354.1 [KE] COG1167 transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002325355.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325356.1 [P] COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit YP_002325359.1 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction YP_002325360.1 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases YP_002325361.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002325365.1 catalyzes the oxidative deamination of D-amino acids YP_002325367.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002325369.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002325370.1 [K] COG1309 transcriptional regulator YP_002325371.1 [QK] COG3284 transcriptional activator of acetoin/glycerol metabolism YP_002325372.1 [T] COG0642 Signal transduction histidine kinase YP_002325374.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_002325375.1 Catalyzes the phosphorylation of UMP to UDP YP_002325376.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002325377.1 [I] COG0020 Undecaprenyl pyrophosphate synthase YP_002325378.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002325379.1 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 YP_002325380.1 [U] COG2831 Hemolysin activation/secretion protein YP_002325381.1 [M] COG2825 outer membrane protein YP_002325382.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002325383.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002325384.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002325385.1 [S] COG1729 Uncharacterized protein conserved in bacteria YP_002325386.1 [R] COG2137 Uncharacterized protein conserved in bacteria YP_002325387.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002325388.1 [J] COG1188 ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_002325389.1 [M] COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_002325390.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325393.1 [J] COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_002325394.1 [K] COG1522 transcriptional regulators YP_002325395.1 [E] COG0520 Selenocysteine lyase YP_002325396.1 [E] COG0531 amino acid transporters YP_002325397.1 [I] COG0657 Esterase/lipase YP_002325398.1 [O] COG1404 Subtilisin-like serine proteases YP_002325399.1 [F] COG2233 Xanthine/uracil permeases YP_002325400.1 [S] COG2135 Uncharacterized conserved protein YP_002325401.1 [G] COG2133 glucose/sorbosone dehydrogenases YP_002325402.1 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_002325403.1 [T] COG2199 FOG: GGDEF domain YP_002325405.1 [K] COG1846 transcriptional regulators YP_002325407.1 [G] COG2213 phosphotransferase system, mannitol-specific IIBC component YP_002325408.1 [G] COG0524 Sugar kinases, ribokinase family YP_002325409.1 [EF] COG0505 Carbamoylphosphate synthase small subunit YP_002325410.1 [R] COG4757 Predicted alpha/beta hydrolase YP_002325412.1 [R] COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol YP_002325413.1 [E] COG1114 Branched-chain amino acid permeases YP_002325414.1 [J] COG0024 methionine aminopeptidase YP_002325415.1 [K] COG0583 transcriptional regulator YP_002325417.1 [O] COG0695 glutaredoxin and related proteins YP_002325418.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_002325419.1 [R] COG0517 FOG: CBS domain YP_002325425.1 [N] COG1419 Flagellar GTP-binding protein YP_002325426.1 [R] COG3560 Predicted oxidoreductase related to nitroreductase YP_002325427.1 [S] COG3110 Uncharacterized protein conserved in bacteria YP_002325428.1 [S] COG3790 Predicted membrane protein YP_002325429.1 [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 YP_002325430.1 [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 YP_002325431.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325432.1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases YP_002325433.1 [G] COG0524 Sugar kinases, ribokinase family YP_002325434.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325435.1 [O] COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like YP_002325436.1 [M] COG2829 outer membrane phospholipase A YP_002325437.1 [P] COG0168 Trk-type K+ transport systems, membrane components YP_002325438.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002325439.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_002325440.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002325441.1 [R] COG1451 Predicted metal-dependent hydrolase YP_002325444.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002325446.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002325447.1 [R] COG1223 Predicted ATPase (AAA+ superfamily) YP_002325448.1 [S] COG1742 Uncharacterized conserved protein YP_002325449.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_002325450.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002325451.1 [K] COG1695 Predicted transcriptional regulators YP_002325452.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002325453.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325454.1 [E] COG2755 Lysophospholipase L1 and related esterases YP_002325455.1 [R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold YP_002325456.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002325457.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325458.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002325459.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002325460.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002325461.1 [S] COG2323 Predicted membrane protein YP_002325462.1 [D] COG2919 Septum formation initiator YP_002325463.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002325464.1 [I] COG4670 acyl CoA:acetate/3-ketoacid CoA transferase YP_002325465.1 [I] COG2057 acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_002325466.1 [I] COG0183 acetyl-CoA acetyltransferase YP_002325467.1 [E] COG0165 Argininosuccinate lyase YP_002325468.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002325469.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325470.1 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit YP_002325471.1 [Q] COG3485 Protocatechuate 3,4-dioxygenase beta subunit YP_002325472.1 [Q] COG3485 Protocatechuate 3,4-dioxygenase beta subunit YP_002325473.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002325474.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325475.1 [M] COG3659 Carbohydrate-selective porin YP_002325476.1 [G] COG4993 glucose dehydrogenase YP_002325478.1 [R] COG2391 Predicted transporter component YP_002325479.1 [R] COG2391 Predicted transporter component YP_002325480.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002325481.1 [K] COG1414 transcriptional regulator YP_002325482.1 [K] COG0583 transcriptional regulator YP_002325483.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325484.1 [R] COG3173 Predicted aminoglycoside phosphotransferase YP_002325485.1 [G] COG0406 Fructose-2,6-bisphosphatase YP_002325486.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325487.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325488.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325490.1 [K] COG1846 transcriptional regulators YP_002325491.1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_002325492.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325495.1 [PR] COG4638 phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit YP_002325496.1 [Q] COG5517 Small subunit of phenylpropionate dioxygenase YP_002325497.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325498.1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002325499.1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002325500.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325501.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_002325502.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325503.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002325504.1 [R] COG2366 protein related to penicillin acylase YP_002325505.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002325506.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_002325507.1 [I] COG2057 acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_002325508.1 [I] COG2057 acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_002325509.1 [I] COG4670 acyl CoA:acetate/3-ketoacid CoA transferase YP_002325510.1 [I] COG1788 acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_002325511.1 [Q] COG3485 Protocatechuate 3,4-dioxygenase beta subunit YP_002325512.1 [Q] COG4829 Muconolactone delta-isomerase YP_002325513.1 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily YP_002325514.1 [K] COG0583 transcriptional regulator YP_002325515.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325516.1 [K] COG2186 transcriptional regulators YP_002325517.1 [K] COG2186 transcriptional regulators YP_002325518.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002325519.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325520.1 [S] COG3802 Uncharacterized protein conserved in bacteria YP_002325521.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002325523.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002325524.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002325525.1 [E] COG1748 Saccharopine dehydrogenase and related proteins YP_002325526.1 [R] COG0693 intracellular protease/amidase YP_002325527.1 [K] COG0789 Predicted transcriptional regulators YP_002325528.1 [R] COG0693 intracellular protease/amidase YP_002325529.1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002325530.1 [K] COG1959 Predicted transcriptional regulator YP_002325531.1 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_002325532.1 [K] COG1309 transcriptional regulator YP_002325533.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325534.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325535.1 [Q] COG4689 acetoacetate decarboxylase YP_002325536.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002325537.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002325538.1 [G] COG2133 glucose/sorbosone dehydrogenases YP_002325539.1 [S] COG4244 Predicted membrane protein YP_002325540.1 [S] COG1359 Uncharacterized conserved protein YP_002325541.1 [Q] COG1335 amidases related to nicotinamidase YP_002325542.1 [K] COG0583 transcriptional regulator YP_002325543.1 [G] COG2133 glucose/sorbosone dehydrogenases YP_002325544.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002325546.1 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_002325547.1 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase YP_002325551.1 [S] COG4304 Uncharacterized protein conserved in bacteria YP_002325552.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325555.1 [S] COG3779 Uncharacterized protein conserved in bacteria YP_002325556.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325557.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325558.1 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases YP_002325559.1 [K] COG2188 transcriptional regulators YP_002325560.1 [G] COG3386 gluconolactonase YP_002325561.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325562.1 [K] COG0583 transcriptional regulator YP_002325563.1 [S] COG3238 Uncharacterized protein conserved in bacteria YP_002325564.1 [S] COG3238 Uncharacterized protein conserved in bacteria YP_002325565.1 [M] COG0845 Membrane-fusion protein YP_002325566.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325567.1 [K] COG1309 transcriptional regulator YP_002325568.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002325569.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002325570.1 [R] COG3970 Fumarylacetoacetate (FAA) hydrolase family protein YP_002325571.1 [K] COG0583 transcriptional regulator YP_002325572.1 [M] COG1087 UDP-glucose 4-epimerase YP_002325573.1 [P] COG2223 nitrate/nitrite transporter YP_002325574.1 [G] COG0362 6-phosphogluconate dehydrogenase YP_002325575.1 [R] COG1064 Zn-dependent alcohol dehydrogenases YP_002325577.1 [FE] COG0462 phosphoribosylpyrophosphate synthetase YP_002325578.1 [H] COG1488 Nicotinic acid phosphoribosyltransferase YP_002325579.1 [F] COG1051 ADP-ribose pyrophosphatase YP_002325580.1 [E] COG0685 5,10-methylenetetrahydrofolate reductase YP_002325582.1 [TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002325583.1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_002325584.1 [V] COG1566 multidrug resistance efflux pump YP_002325585.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325586.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325587.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325588.1 [MU] COG1538 outer membrane protein YP_002325590.1 [R] COG0496 Predicted acid phosphatase YP_002325593.1 [TK] COG0317 guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002325594.1 [KL] COG1061 DNA or RNA helicases of superfamily II YP_002325596.1 [K] COG1309 transcriptional regulator YP_002325600.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002325601.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002325602.1 [K] COG0583 transcriptional regulator YP_002325603.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325604.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325605.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002325606.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325608.1 [T] COG0642 Signal transduction histidine kinase YP_002325609.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002325610.1 [M] COG0845 Membrane-fusion protein YP_002325611.1 [V] COG0841 Cation/multidrug efflux pump YP_002325612.1 [MU] COG1538 outer membrane protein YP_002325613.1 [R] COG1073 Hydrolases of the alpha/beta superfamily YP_002325614.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002325615.1 [K] COG1309 transcriptional regulator YP_002325616.1 [E] COG0665 glycine/D-amino acid oxidases (deaminating) YP_002325618.1 [I] COG2067 Long-chain fatty acid transport protein YP_002325619.1 [NU] COG3539 P pilus assembly protein, pilin FimA YP_002325620.1 [NU] COG3121 P pilus assembly protein, chaperone PapD YP_002325621.1 [NU] COG3188 P pilus assembly protein, porin PapC YP_002325622.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325624.1 [R] COG1064 Zn-dependent alcohol dehydrogenases YP_002325626.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325629.1 [I] COG1502 phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_002325630.1 [L] COG3663 G:T/U mismatch-specific DNA glycosylase YP_002325633.1 [E] COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog YP_002325634.1 [H] COG2896 molybdenum cofactor biosynthesis enzyme YP_002325635.1 with PqqC converts a biosynthetic intermediate to pyrroloquinoline quinone YP_002325636.1 Required in the synthesis of PPQ, but its exact function is unknown YP_002325637.1 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I YP_002325638.1 possibly involved in transport of pyrroloquinoline quinone transport YP_002325639.1 [P] COG0855 polyphosphate kinase YP_002325640.1 [P] COG0855 polyphosphate kinase YP_002325641.1 [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases YP_002325642.1 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins YP_002325643.1 [Q] COG1335 amidases related to nicotinamidase YP_002325644.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325645.1 [P] COG1118 ABC-type sulfate/molybdate transport systems, ATPase component YP_002325646.1 [P] COG1178 ABC-type Fe3+ transport system, permease component YP_002325647.1 [P] COG0725 ABC-type molybdate transport system, periplasmic component YP_002325648.1 [R] COG2005 N-terminal domain of molybdenum-binding protein YP_002325649.1 [PR] COG4638 phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit YP_002325650.1 [Q] COG5517 Small subunit of phenylpropionate dioxygenase YP_002325651.1 catalyzes the formation of catechol from anthranilate YP_002325652.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325653.1 [C] COG4313 protein involved in meta-pathway of phenol degradation YP_002325654.1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002325655.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325656.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325657.1 [Q] COG0412 Dienelactone hydrolase and related enzymes YP_002325658.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325659.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325660.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_002325661.1 [GE] COG2610 H+/gluconate symporter and related permeases YP_002325663.1 [K] COG0583 transcriptional regulator YP_002325664.1 [I] COG4670 acyl CoA:acetate/3-ketoacid CoA transferase YP_002325665.1 [I] COG4670 acyl CoA:acetate/3-ketoacid CoA transferase YP_002325666.1 [I] COG2031 Short chain fatty acids transporter YP_002325667.1 [I] COG0183 acetyl-CoA acetyltransferase YP_002325668.1 [K] COG0583 transcriptional regulator YP_002325669.1 [K] COG0583 transcriptional regulator YP_002325672.1 catalyzes the formation of fumarate from aspartate YP_002325673.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325674.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325675.1 [S] COG3536 Uncharacterized protein conserved in bacteria YP_002325676.1 [C] COG1413 FOG: HEAT repeat YP_002325677.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002325678.1 [E] COG1174 ABC-type proline/glycine betaine transport systems, permease component YP_002325679.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002325680.1 [C] COG1145 Ferredoxin YP_002325681.1 [H] COG0029 Aspartate oxidase YP_002325682.1 [K] COG2188 transcriptional regulators YP_002325683.1 [P] COG2059 Chromate transport protein ChrA YP_002325684.1 [L] COG4227 Antirestriction protein YP_002325685.1 [K] COG1733 Predicted transcriptional regulators YP_002325686.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325687.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325688.1 [E] COG0460 Homoserine dehydrogenase YP_002325689.1 [R] COG0730 Predicted permeases YP_002325690.1 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002325691.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002325692.1 [KE] COG3283 transcriptional regulator of aromatic amino acids metabolism YP_002325693.1 [S] COG3781 Predicted membrane protein YP_002325694.1 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_002325695.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325696.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002325697.1 [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_002325698.1 [HI] COG1154 Deoxyxylulose-5-phosphate synthase YP_002325699.1 [G] COG3959 transketolase, N-terminal subunit YP_002325700.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002325701.1 [QK] COG3284 transcriptional activator of acetoin/glycerol metabolism YP_002325702.1 [K] COG0819 transcription activator YP_002325703.1 [T] COG2199 FOG: GGDEF domain YP_002325704.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002325705.1 involved in methylation of ribosomal protein L3 YP_002325706.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002325707.1 [S] COG3825 Uncharacterized protein conserved in bacteria YP_002325708.1 [O] COG0542 ATPases with chaperone activity, ATP-binding subunit YP_002325710.1 [S] COG3100 Uncharacterized protein conserved in bacteria YP_002325711.1 [R] COG3668 Plasmid stabilization system protein YP_002325714.1 [J] COG0349 ribonuclease D YP_002325715.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002325716.1 [S] COG0718 Uncharacterized protein conserved in bacteria YP_002325718.1 catalyzes the conversion of O-succinylhomoserine into homocysteine YP_002325719.1 [I] COG3243 poly(3-hydroxyalkanoate) synthetase YP_002325720.1 [QR] COG0500 SAM-dependent methyltransferases YP_002325724.1 [S] COG3791 Uncharacterized conserved protein YP_002325726.1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_002325727.1 similar to BP0840 protein; [M] COG3203 outer membrane protein (porin) YP_002325728.1 [S] COG3753 Uncharacterized protein conserved in bacteria YP_002325729.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325730.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325731.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002325732.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325734.1 [S] COG3182 Uncharacterized iron-regulated membrane protein YP_002325735.1 [R] COG0730 Predicted permeases YP_002325736.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002325737.1 [H] COG0368 Cobalamin-5-phosphate synthase YP_002325739.1 [G] COG0588 phosphoglycerate mutase 1 YP_002325740.1 [H] COG2038 NaMN:DMB phosphoribosyltransferase YP_002325741.1 [H] COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase YP_002325743.1 [G] COG0246 Mannitol-1-phosphate/altronate dehydrogenases YP_002325744.1 [J] COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_002325746.1 [S] COG3182 Uncharacterized iron-regulated membrane protein YP_002325747.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325748.1 [H] COG0684 Demethylmenaquinone methyltransferase YP_002325750.1 [Q] COG4264 Siderophore synthetase component YP_002325751.1 [Q] COG4264 Siderophore synthetase component YP_002325752.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325753.1 [Q] COG3486 lysine/ornithine N-monooxygenase YP_002325754.1 [Q] COG4264 Siderophore synthetase component YP_002325755.1 [Q] COG4264 Siderophore synthetase component YP_002325756.1 [S] COG2606 Uncharacterized conserved protein YP_002325758.1 [R] COG0661 Predicted unusual protein kinase YP_002325759.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325760.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325761.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325762.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325763.1 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase YP_002325764.1 [L] COG0776 Bacterial nucleoid DNA-binding protein YP_002325765.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325767.1 [K] COG1959 Predicted transcriptional regulator YP_002325768.1 [E] COG0520 Selenocysteine lyase YP_002325769.1 [C] COG0822 NifU homolog involved in Fe-S cluster formation YP_002325770.1 [S] COG0316 Uncharacterized conserved protein YP_002325771.1 [O] COG1076 DnaJ-domain-containing proteins 1 YP_002325772.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002325773.1 [C] COG0633 Ferredoxin YP_002325774.1 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) YP_002325775.1 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_002325776.1 [L] COG0556 Helicase subunit of the DNA excision repair complex YP_002325778.1 [P] COG2837 Predicted iron-dependent peroxidase YP_002325779.1 [O] COG0695 glutaredoxin and related proteins YP_002325780.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002325781.1 [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_002325782.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002325784.1 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_002325786.1 [S] COG2135 Uncharacterized conserved protein YP_002325787.1 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002325788.1 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002325789.1 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002325790.1 [E] COG0339 Zn-dependent oligopeptidases YP_002325792.1 [E] COG4166 ABC-type oligopeptide transport system, periplasmic component YP_002325793.1 [E] COG0747 ABC-type dipeptide transport system, periplasmic component YP_002325794.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002325795.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325796.1 [U] COG0811 biopolymer transport proteins YP_002325797.1 [U] COG0848 biopolymer transport protein YP_002325798.1 [U] COG0848 biopolymer transport protein YP_002325799.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002325800.1 [R] COG1485 Predicted ATPase YP_002325801.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325802.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002325803.1 [S] COG2431 Predicted membrane protein YP_002325804.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002325806.1 [L] COG0776 Bacterial nucleoid DNA-binding protein YP_002325807.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002325808.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002325810.1 [FJ] COG0590 Cytosine/adenosine deaminases YP_002325811.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002325812.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002325813.1 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase YP_002325814.1 [U] COG3156 Type II secretory pathway, component PulK YP_002325816.1 [NU] COG2165 Type II secretory pathway, pseudopilin PulG YP_002325818.1 [K] COG1309 transcriptional regulator YP_002325819.1 [L] COG0084 Mg-dependent DNase YP_002325820.1 [NU] COG3215 Tfp pilus assembly protein PilZ YP_002325821.1 [G] COG0574 phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002325822.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002325823.1 [M] COG1663 Tetraacyldisaccharide-1-P 4'-kinase YP_002325824.1 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components YP_002325825.1 [U] COG0848 biopolymer transport protein YP_002325826.1 [U] COG0811 biopolymer transport proteins YP_002325827.1 [K] COG1475 Predicted transcriptional regulators YP_002325828.1 [D] COG0455 ATPases involved in chromosome partitioning YP_002325829.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002325830.1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) YP_002325831.1 [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases YP_002325832.1 [M] COG1452 Organic solvent tolerance protein OstA YP_002325833.1 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase YP_002325834.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_002325836.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002325837.1 [S] COG3651 Uncharacterized protein conserved in bacteria YP_002325838.1 [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation YP_002325839.1 [S] COG2850 Uncharacterized conserved protein YP_002325840.1 [K] COG1309 transcriptional regulator YP_002325841.1 [K] COG0640 Predicted transcriptional regulators YP_002325842.1 involved in the import of serine and threonine coupled with the import of sodium YP_002325843.1 [S] COG3619 Predicted membrane protein YP_002325844.1 [S] COG3122 Uncharacterized protein conserved in bacteria YP_002325845.1 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components YP_002325846.1 [I] COG2030 acyl dehydratase YP_002325847.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325848.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002325849.1 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family YP_002325850.1 [R] COG4147 Predicted symporter YP_002325851.1 [K] COG1522 transcriptional regulators YP_002325852.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain YP_002325853.1 [S] COG2320 Uncharacterized conserved protein YP_002325854.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002325856.1 [S] COG3698 Predicted periplasmic protein YP_002325857.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325858.1 [S] COG2353 Uncharacterized conserved protein YP_002325859.1 [O] COG1764 Predicted redox protein, regulator of disulfide bond formation YP_002325860.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002325861.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002325864.1 [R] COG3030 protein affecting phage T7 exclusion by the F plasmid YP_002325865.1 [V] COG2602 beta-lactamase class D YP_002325866.1 [M] COG1247 Sortase and related acyltransferases YP_002325867.1 [K] COG1396 Predicted transcriptional regulators YP_002325869.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002325870.1 [G] COG0063 Predicted sugar kinase YP_002325871.1 [C] COG1600 Uncharacterized Fe-S protein YP_002325872.1 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes YP_002325875.1 [NU] COG3539 P pilus assembly protein, pilin FimA YP_002325876.1 [NU] COG3121 P pilus assembly protein, chaperone PapD YP_002325877.1 [NU] COG3188 P pilus assembly protein, porin PapC YP_002325878.1 [NU] COG3539 P pilus assembly protein, pilin FimA YP_002325880.1 [K] COG0583 transcriptional regulator YP_002325881.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002325883.1 [F] COG1457 Purine-cytosine permease and related proteins YP_002325884.1 [S] COG4125 Predicted membrane protein YP_002325885.1 [K] COG0583 transcriptional regulator YP_002325887.1 [L] COG0582 Integrase YP_002325889.1 [K] COG1309 transcriptional regulator YP_002325890.1 [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002325891.1 [S] COG0217 Uncharacterized conserved protein YP_002325892.1 [K] COG1522 transcriptional regulators YP_002325894.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002325895.1 [E] COG4597 ABC-type amino acid transport system, permease component YP_002325896.1 [E] COG0765 ABC-type amino acid transport system, permease component YP_002325897.1 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_002325898.1 [O] COG0625 glutathione S-transferase YP_002325899.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325900.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325901.1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_002325902.1 [P] COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen YP_002325903.1 [P] COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen YP_002325904.1 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002325905.1 [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I YP_002325906.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002325907.1 [S] COG4539 Predicted membrane protein YP_002325908.1 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_002325911.1 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) YP_002325912.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325913.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325914.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_002325915.1 [O] COG2844 UTP:GlnB (protein PII) uridylyltransferase YP_002325916.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_002325917.1 [E] COG1280 threonine efflux protein YP_002325918.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002325919.1 [O] COG0386 glutathione peroxidase YP_002325920.1 [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase YP_002325921.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002325922.1 [C] COG1301 Na+/H+-dicarboxylate symporters YP_002325923.1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D YP_002325924.1 [L] COG0587 DNA polymerase III, alpha subunit YP_002325925.1 [J] COG0219 Predicted rRNA methylase (SpoU class) YP_002325926.1 [R] COG0110 acetyltransferase (isoleucine patch superfamily) YP_002325929.1 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_002325930.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325931.1 [P] COG2059 Chromate transport protein ChrA YP_002325932.1 [P] COG2059 Chromate transport protein ChrA YP_002325933.1 [K] COG0583 transcriptional regulator YP_002325934.1 [R] COG0385 Predicted Na+-dependent transporter YP_002325935.1 [K] COG0640 Predicted transcriptional regulators YP_002325936.1 [P] COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_002325937.1 [S] COG4317 Uncharacterized protein conserved in bacteria YP_002325938.1 [Q] COG1228 Imidazolonepropionase and related amidohydrolases YP_002325939.1 [Q] COG1335 amidases related to nicotinamidase YP_002325940.1 [K] COG0583 transcriptional regulator YP_002325941.1 [K] COG2186 transcriptional regulators YP_002325942.1 [F] COG1457 Purine-cytosine permease and related proteins YP_002325943.1 [E] COG4126 Hydantoin racemase YP_002325944.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_002325945.1 [E] COG1174 ABC-type proline/glycine betaine transport systems, permease component YP_002325946.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002325947.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002325948.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325949.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325950.1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_002325951.1 [I] COG1960 acyl-CoA dehydrogenases YP_002325954.1 [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 YP_002325955.1 [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 YP_002325957.1 [KE] COG1167 transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002325958.1 [K] COG0583 transcriptional regulator YP_002325959.1 [K] COG0583 transcriptional regulator YP_002325960.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325961.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325962.1 [Q] COG3321 polyketide synthase modules and related proteins YP_002325963.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_002325964.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325965.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_002325966.1 acyl carrier protein of malonate decarboxylase YP_002325967.1 catalyzes the reversible formation of 2'-(5''-triphosphoribosyl)-3'dephospho-CoA from 3-dephospho-CoA YP_002325968.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325970.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002325971.1 [J] COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_002325972.1 [K] COG2808 transcriptional regulator YP_002325973.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002325974.1 [M] COG1346 effector of murein hydrolase YP_002325975.1 [R] COG1380 effector of murein hydrolase LrgA YP_002325976.1 [K] COG0583 transcriptional regulator YP_002325977.1 [O] COG0625 glutathione S-transferase YP_002325978.1 [O] COG0625 glutathione S-transferase YP_002325979.1 [K] COG0583 transcriptional regulator YP_002325980.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002325981.1 [P] COG0607 Rhodanese-related sulfurtransferase YP_002325982.1 [E] COG2171 Tetrahydrodipicolinate N-succinyltransferase YP_002325983.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002325984.1 [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_002325986.1 [E] COG1280 threonine efflux protein YP_002325987.1 [K] COG0583 transcriptional regulator YP_002325988.1 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_002325989.1 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_002325990.1 [P] COG1135 ABC-type metal ion transport system, ATPase component YP_002325991.1 [E] COG0765 ABC-type amino acid transport system, permease component YP_002325992.1 [E] COG4597 ABC-type amino acid transport system, permease component YP_002325993.1 [R] COG2388 Predicted acetyltransferase YP_002325994.1 [T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain YP_002325995.1 [T] COG0642 Signal transduction histidine kinase YP_002325996.1 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases YP_002325997.1 [K] COG1522 transcriptional regulators YP_002325998.1 [E] COG1280 threonine efflux protein YP_002325999.1 Contains: protein samA'; [KT] COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) YP_002326001.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326003.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326004.1 [P] COG0753 Catalase YP_002326005.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326006.1 [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) YP_002326007.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326013.1 [K] COG0583 transcriptional regulator YP_002326015.1 [E] COG2755 Lysophospholipase L1 and related esterases YP_002326017.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326018.1 [IQ] COG0318 acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002326019.1 [K] COG1309 transcriptional regulator YP_002326020.1 Isovaleryl-CoA dehydrogenase, mitochondrial precursor(IVD); [I] COG1960 acyl-CoA dehydrogenases YP_002326021.1 [I] COG4799 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_002326022.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002326023.1 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) YP_002326024.1 [C] COG5016 Pyruvate/oxaloacetate carboxyltransferase YP_002326025.1 [K] COG0583 transcriptional regulator YP_002326026.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_002326027.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326028.1 [I] COG1960 acyl-CoA dehydrogenases YP_002326029.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002326030.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326032.1 [I] COG2057 acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_002326033.1 [I] COG4670 acyl CoA:acetate/3-ketoacid CoA transferase YP_002326034.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326035.1 [I] COG1960 acyl-CoA dehydrogenases YP_002326036.1 Enoyl-CoA hydratase, mitochondrial precursor; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002326037.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002326038.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation YP_002326039.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002326040.1 [K] COG1414 transcriptional regulator YP_002326041.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326042.1 [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_002326043.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002326044.1 [K] COG1414 transcriptional regulator YP_002326045.1 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_002326046.1 [I] COG1960 acyl-CoA dehydrogenases YP_002326047.1 [S] COG0398 Uncharacterized conserved protein YP_002326048.1 catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate YP_002326049.1 [E] COG0520 Selenocysteine lyase YP_002326050.1 [R] COG0579 Predicted dehydrogenase YP_002326051.1 [P] COG1178 ABC-type Fe3+ transport system, permease component YP_002326052.1 [G] COG3839 ABC-type sugar transport systems, ATPase components YP_002326053.1 [P] COG1840 ABC-type Fe3+ transport system, periplasmic component YP_002326054.1 [K] COG2188 transcriptional regulators YP_002326055.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_002326056.1 [K] COG1414 transcriptional regulator YP_002326057.1 [I] COG1182 acyl carrier protein phosphodiesterase YP_002326058.1 [K] COG0583 transcriptional regulator YP_002326059.1 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit YP_002326060.1 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_002326061.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326062.1 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases YP_002326064.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326065.1 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_002326066.1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002326067.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326068.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326069.1 [K] COG1802 transcriptional regulators YP_002326070.1 [S] COG5470 Uncharacterized conserved protein YP_002326071.1 [C] COG3038 Cytochrome B561 YP_002326072.1 [P] COG0753 Catalase YP_002326073.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326074.1 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases YP_002326075.1 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_002326076.1 [K] COG0583 transcriptional regulator YP_002326081.1 [K] COG1278 Cold shock proteins YP_002326087.1 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase YP_002326088.1 [L] COG0210 Superfamily I DNA and RNA helicases YP_002326090.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326091.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002326092.1 [M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) YP_002326093.1 [K] COG3327 phenylacetic acid-responsive transcriptional repressor YP_002326094.1 [IQ] COG0318 acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002326095.1 [I] COG0183 acetyl-CoA acetyltransferase YP_002326096.1 [I] COG1250 3-hydroxyacyl-CoA dehydrogenase YP_002326097.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002326098.1 [H] COG0447 Dihydroxynaphthoic acid synthase YP_002326099.1 [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_002326100.1 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme YP_002326101.1 [S] COG3396 Uncharacterized conserved protein YP_002326102.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_002326103.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_002326104.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_002326105.1 [E] COG1760 L-serine deaminase YP_002326106.1 [E] COG0531 amino acid transporters YP_002326107.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326108.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326109.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326110.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002326111.1 [E] COG0665 glycine/D-amino acid oxidases (deaminating) YP_002326112.1 [E] COG3938 Proline racemase YP_002326113.1 [K] COG1802 transcriptional regulators YP_002326114.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002326115.1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_002326116.1 [R] COG3042 hemolysin YP_002326117.1 [K] COG0789 Predicted transcriptional regulators YP_002326118.1 [S] COG1636 Uncharacterized protein conserved in bacteria YP_002326119.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002326120.1 [S] COG3214 Uncharacterized protein conserved in bacteria YP_002326121.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326122.1 [FJ] COG0590 Cytosine/adenosine deaminases YP_002326123.1 [R] COG0666 FOG: Ankyrin repeat YP_002326124.1 [K] COG0583 transcriptional regulator YP_002326125.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326126.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326127.1 [S] COG3455 Uncharacterized protein conserved in bacteria YP_002326128.1 [S] COG3522 Uncharacterized protein conserved in bacteria YP_002326129.1 [S] COG3515 Uncharacterized protein conserved in bacteria YP_002326130.1 [O] COG0466 ATP-dependent Lon protease, bacterial type YP_002326131.1 [S] COG4104 Uncharacterized conserved protein YP_002326132.1 [M] COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_002326133.1 [S] COG3913 Uncharacterized protein conserved in bacteria YP_002326134.1 [S] COG3523 Uncharacterized protein conserved in bacteria YP_002326136.1 [S] COG3520 Uncharacterized protein conserved in bacteria YP_002326137.1 [S] COG3519 Uncharacterized protein conserved in bacteria YP_002326138.1 [S] COG3518 Uncharacterized protein conserved in bacteria YP_002326139.1 [S] COG3157 Hemolysin-coregulated protein (uncharacterized) YP_002326140.1 [S] COG3517 Uncharacterized protein conserved in bacteria YP_002326141.1 [S] COG3516 Uncharacterized protein conserved in bacteria YP_002326143.1 [S] COG4460 Uncharacterized protein conserved in bacteria YP_002326145.1 [E] COG4176 ABC-type proline/glycine betaine transport system, permease component YP_002326146.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002326147.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002326148.1 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_002326149.1 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain YP_002326151.1 [P] COG1178 ABC-type Fe3+ transport system, permease component YP_002326152.1 [R] COG2249 NADPH-quinone reductase (modulator of drug activity B) YP_002326153.1 [I] COG0511 Biotin carboxyl carrier protein YP_002326154.1 [S] COG3665 Uncharacterized conserved protein YP_002326155.1 [S] COG3665 Uncharacterized conserved protein YP_002326156.1 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_002326157.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326158.1 [K] COG1309 transcriptional regulator YP_002326162.1 [R] COG0790 FOG: TPR repeat, SEL1 subfamily YP_002326163.1 [P] COG0038 Chloride channel protein EriC YP_002326164.1 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) YP_002326165.1 [E] COG1984 Allophanate hydrolase subunit 2 YP_002326166.1 [S] COG4336 Uncharacterized conserved protein YP_002326167.1 [R] COG1540 Uncharacterized proteins, homologs of lactam utilization protein B YP_002326168.1 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family YP_002326169.1 [K] COG0583 transcriptional regulator YP_002326173.1 [M] COG3209 Rhs family protein YP_002326177.1 [M] COG3209 Rhs family protein YP_002326178.1 [S] COG3501 Uncharacterized protein conserved in bacteria YP_002326179.1 [V] COG2367 beta-lactamase class A YP_002326183.1 [I] COG1250 3-hydroxyacyl-CoA dehydrogenase YP_002326187.1 [S] COG4731 Uncharacterized protein conserved in bacteria YP_002326188.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326189.1 [K] COG1309 transcriptional regulator YP_002326190.1 [M] COG1560 Lauroyl/myristoyl acyltransferase YP_002326191.1 [T] COG2200 FOG: EAL domain YP_002326193.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002326194.1 [K] COG1522 transcriptional regulators YP_002326195.1 This protein performs the mismatch recognition step during the DNA repair process YP_002326196.1 [R] COG3153 Predicted acetyltransferase YP_002326197.1 [C] COG1146 Ferredoxin YP_002326199.1 [R] COG4122 Predicted O-methyltransferase YP_002326200.1 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_002326201.1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_002326202.1 [S] COG1739 Uncharacterized conserved protein YP_002326203.1 [M] COG0845 Membrane-fusion protein YP_002326204.1 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components YP_002326205.1 [MU] COG1538 outer membrane protein YP_002326206.1 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component YP_002326207.1 [S] COG1934 Uncharacterized protein conserved in bacteria YP_002326209.1 [R] COG0561 Predicted hydrolases of the HAD superfamily YP_002326210.1 [R] COG0517 FOG: CBS domain YP_002326211.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002326212.1 [L] COG0582 Integrase YP_002326216.1 [R] COG3926 secretion activating protein YP_002326220.1 [S] COG1357 Uncharacterized low-complexity proteins YP_002326222.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326223.1 [S] COG3566 Uncharacterized protein conserved in bacteria YP_002326226.1 [S] COG2369 Uncharacterized protein, homolog of phage Mu protein gp30 YP_002326227.1 [S] COG3567 Uncharacterized protein conserved in bacteria YP_002326228.1 [S] COG5410 Uncharacterized protein conserved in bacteria YP_002326229.1 [S] COG5556 Uncharacterized conserved protein YP_002326230.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326237.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326238.1 [S] COG3652 Predicted outer membrane protein YP_002326240.1 [K] COG1733 Predicted transcriptional regulators YP_002326241.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326245.1 [E] COG0345 Pyrroline-5-carboxylate reductase YP_002326247.1 [K] COG1278 Cold shock proteins YP_002326248.1 [E] COG1280 threonine efflux protein YP_002326249.1 [R] COG3926 secretion activating protein YP_002326251.1 [K] COG2932 Predicted transcriptional regulator YP_002326253.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002326256.1 [E] COG1280 threonine efflux protein YP_002326258.1 [C] COG1145 Ferredoxin YP_002326259.1 [S] COG3791 Uncharacterized conserved protein YP_002326260.1 [K] COG0789 Predicted transcriptional regulators YP_002326261.1 [P] COG2217 Cation transport ATPase YP_002326262.1 [P] COG2608 Copper chaperone YP_002326263.1 [K] COG0583 transcriptional regulator YP_002326264.1 [PR] COG4638 phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit YP_002326265.1 [Q] COG5517 Small subunit of phenylpropionate dioxygenase YP_002326266.1 [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_002326267.1 catalyzes the degradation of 2-hydro-1,2-dihydroxy benzoate to catechol YP_002326268.1 [Q] COG3135 Uncharacterized protein involved in benzoate metabolism YP_002326269.1 [S] COG0398 Uncharacterized conserved protein YP_002326270.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326271.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002326272.1 [L] COG1643 HrpA-like helicases YP_002326273.1 [O] COG1225 Peroxiredoxin YP_002326275.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326276.1 [S] COG4728 Uncharacterized protein conserved in bacteria YP_002326277.1 [O] COG0492 Thioredoxin reductase YP_002326278.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326279.1 [O] COG0625 glutathione S-transferase YP_002326280.1 [R] COG2374 Predicted extracellular nuclease YP_002326281.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002326282.1 [O] COG0625 glutathione S-transferase YP_002326283.1 [S] COG5495 Uncharacterized conserved protein YP_002326284.1 [M] COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_002326285.1 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases YP_002326286.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002326288.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002326290.1 [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) YP_002326291.1 [O] COG0464 ATPases of the AAA+ class YP_002326292.1 [D] COG4942 Membrane-bound metallopeptidase YP_002326293.1 [KR] COG0454 histone acetyltransferase HPA2 and related acetyltransferases YP_002326294.1 [O] COG1764 Predicted redox protein, regulator of disulfide bond formation YP_002326295.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002326296.1 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase YP_002326297.1 [O] COG0501 Zn-dependent protease with chaperone function YP_002326299.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002326300.1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_002326302.1 [G] COG0057 glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_002326303.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002326304.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002326305.1 [T] COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing) YP_002326306.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002326307.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326308.1 [C] COG3038 Cytochrome B561 YP_002326309.1 catalyzes the formation of inosine from adenosine YP_002326310.1 [F] COG2233 Xanthine/uracil permeases YP_002326312.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002326313.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326314.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002326315.1 [R] COG1741 Pirin-related protein YP_002326316.1 [K] COG1309 transcriptional regulator YP_002326317.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002326318.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326319.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002326320.1 [Q] COG3315 O-methyltransferase involved in polyketide biosynthesis YP_002326321.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326322.1 [P] COG2072 Predicted flavoprotein involved in K+ transport YP_002326323.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326324.1 [I] COG0657 Esterase/lipase YP_002326325.1 [E] COG2303 Choline dehydrogenase and related flavoproteins YP_002326326.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326327.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326328.1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases YP_002326329.1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002326330.1 [K] COG1802 transcriptional regulators YP_002326331.1 [K] COG1846 transcriptional regulators YP_002326332.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326333.1 catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA YP_002326334.1 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_002326335.1 catalyzes the conversion of ferulic acid to feruloyl-CoA YP_002326336.1 [I] COG1960 acyl-CoA dehydrogenases YP_002326337.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326338.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326339.1 [I] COG1607 acyl-CoA hydrolase YP_002326340.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326341.1 [K] COG1802 transcriptional regulators YP_002326342.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326343.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_002326345.1 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily YP_002326346.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326347.1 [G] COG2721 Altronate dehydratase YP_002326348.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002326349.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326350.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326353.1 [E] COG0531 amino acid transporters YP_002326354.1 [E] COG3138 Arginine/ornithine N-succinyltransferase beta subunit YP_002326355.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_002326356.1 [K] COG1522 transcriptional regulators YP_002326357.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326358.1 [S] COG4922 Uncharacterized protein conserved in bacteria YP_002326359.1 [K] COG2186 transcriptional regulators YP_002326361.1 [E] COG0833 amino acid transporters YP_002326362.1 [E] COG0665 glycine/D-amino acid oxidases (deaminating) YP_002326363.1 [E] COG0833 amino acid transporters YP_002326364.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326365.1 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits YP_002326368.1 [M] COG3209 Rhs family protein YP_002326369.1 [S] COG3501 Uncharacterized protein conserved in bacteria YP_002326370.1 [K] COG1309 transcriptional regulator YP_002326373.1 [P] COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen YP_002326374.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002326375.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_002326376.1 [T] COG2199 FOG: GGDEF domain YP_002326377.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002326378.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002326379.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002326381.1 [M] COG3209 Rhs family protein YP_002326382.1 [M] COG3209 Rhs family protein YP_002326386.1 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002326387.1 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase YP_002326388.1 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002326389.1 [R] COG4174 ABC-type uncharacterized transport system, permease component YP_002326390.1 [E] COG0747 ABC-type dipeptide transport system, periplasmic component YP_002326391.1 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002326392.1 [L] COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases YP_002326393.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326394.1 [F] COG1051 ADP-ribose pyrophosphatase YP_002326395.1 [I] COG0657 Esterase/lipase YP_002326396.1 [R] COG2823 Predicted periplasmic or secreted lipoprotein YP_002326397.1 [L] COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_002326398.1 [H] COG1010 Precorrin-3B methylase YP_002326399.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326400.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002326401.1 [E] COG1280 threonine efflux protein YP_002326402.1 [P] COG1230 Co/Zn/Cd efflux system component YP_002326403.1 [K] COG0789 Predicted transcriptional regulators YP_002326404.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326406.1 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_002326407.1 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_002326408.1 [E] COG0006 Xaa-Pro aminopeptidase YP_002326409.1 [E] COG0006 Xaa-Pro aminopeptidase YP_002326410.1 [S] COG3079 Uncharacterized protein conserved in bacteria YP_002326411.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326413.1 [L] COG0582 Integrase YP_002326415.1 [K] COG1278 Cold shock proteins YP_002326417.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326418.1 [S] COG4104 Uncharacterized conserved protein YP_002326421.1 [R] COG3926 secretion activating protein YP_002326429.1 [D] COG1196 Chromosome segregation ATPases YP_002326431.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326433.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326440.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326441.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326445.1 [T] COG5585 NAD+--asparagine ADP-ribosyltransferase YP_002326447.1 [R] COG1783 Phage terminase large subunit YP_002326448.1 [S] COG5556 Uncharacterized conserved protein YP_002326449.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326452.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326455.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326459.1 [L] COG0863 DNA modification methylase YP_002326462.1 [K] COG2932 Predicted transcriptional regulator YP_002326463.1 [O] COG0464 ATPases of the AAA+ class YP_002326464.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326472.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326476.1 [H] COG0212 5-formyltetrahydrofolate cyclo-ligase YP_002326477.1 [O] COG1066 Predicted ATP-dependent serine protease YP_002326478.1 [S] COG1576 Uncharacterized conserved protein YP_002326479.1 [S] COG3384 Uncharacterized conserved protein YP_002326480.1 [O] COG3187 Heat shock protein YP_002326481.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002326482.1 [C] COG1145 Ferredoxin YP_002326484.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002326487.1 [M] COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_002326488.1 [L] COG0742 N6-adenine-specific methylase YP_002326489.1 [O] COG2370 Hydrogenase/urease accessory protein YP_002326490.1 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase YP_002326491.1 [O] COG0830 urease accessory protein UreF YP_002326492.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_002326493.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_002326494.1 [E] COG0832 Urea amidohydrolase (urease) beta subunit YP_002326495.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_002326496.1 [O] COG0829 urease accessory protein UreH YP_002326499.1 [MP] COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance YP_002326500.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_002326501.1 [K] COG0583 transcriptional regulator YP_002326502.1 [R] COG1253 Hemolysins and related proteins containing CBS domains YP_002326503.1 [C] COG3069 C4-dicarboxylate transporter YP_002326505.1 [S] COG3644 Uncharacterized protein conserved in bacteria YP_002326506.1 [J] COG4108 peptide chain release factor RF-3 YP_002326507.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002326510.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002326513.1 [C] COG1773 Rubredoxin YP_002326514.1 [C] COG1251 NAD(P)H-nitrite reductase YP_002326515.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326516.1 [K] COG0583 transcriptional regulator YP_002326518.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002326519.1 [M] COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC YP_002326520.1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002326521.1 [M] COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_002326522.1 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_002326523.1 [E] COG2755 Lysophospholipase L1 and related esterases YP_002326524.1 similar to chloroplast beta carbonic anhydrase; [P] COG0288 Carbonic anhydrase YP_002326525.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326527.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_002326528.1 [O] COG0694 Thioredoxin-like proteins and domains YP_002326529.1 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002326530.1 [P] COG3119 Arylsulfatase A and related enzymes YP_002326531.1 [S] COG1262 Uncharacterized conserved protein YP_002326532.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326535.1 [P] COG0306 phosphate/sulphate permeases YP_002326537.1 one of two methionine synthases in Escherichia coli; meth catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002326538.1 [G] COG0021 transketolase YP_002326539.1 [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_002326540.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326541.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326542.1 [K] COG0583 transcriptional regulator YP_002326544.1 [G] COG2017 Galactose mutarotase and related enzymes YP_002326545.1 [G] COG2814 Arabinose efflux permease YP_002326546.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326547.1 catalyzes the formation of glutamate from glutamine YP_002326548.1 [J] COG0242 N-formylmethionyl-tRNA deformylase YP_002326550.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326551.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326552.1 [E] COG3962 acetolactate synthase YP_002326553.1 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_002326554.1 catalyzes the formation of L-aspartate to iminoaspartate in NAD(+) biosynthesis YP_002326555.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326556.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326557.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326558.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326559.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002326560.1 [E] COG0346 Lactoylglutathione lyase and related lyases YP_002326561.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326562.1 [PR] COG4638 phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit YP_002326563.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326564.1 [K] COG1414 transcriptional regulator YP_002326566.1 [H] COG3201 Nicotinamide mononucleotide transporter YP_002326567.1 Enoyl-CoA hydratase, mitochondrial precursor; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002326569.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_002326570.1 [G] COG0726 Predicted xylanase/chitin deacetylase YP_002326571.1 [O] COG1047 peptidyl-prolyl cis-trans isomerases 2 YP_002326572.1 [S] COG4681 Uncharacterized protein conserved in bacteria YP_002326573.1 [C] COG1301 Na+/H+-dicarboxylate symporters YP_002326574.1 [R] COG0523 GTPases (G3E family) YP_002326576.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002326577.1 [U] COG2095 Multiple antibiotic transporter YP_002326578.1 proton-motive-force-driven choline transporter YP_002326579.1 [M] COG1292 Choline-glycine betaine transporter YP_002326580.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_002326581.1 catalyzes the formation of betaine from betaine aldehyde YP_002326582.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002326583.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002326585.1 [E] COG0646 methionine synthase I (cobalamin-dependent), methyltransferase domain YP_002326586.1 [E] COG0531 amino acid transporters YP_002326588.1 [S] COG3619 Predicted membrane protein YP_002326590.1 [K] COG0583 transcriptional regulator YP_002326591.1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_002326592.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326596.1 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family YP_002326597.1 [L] COG0084 Mg-dependent DNase YP_002326598.1 [K] COG0583 transcriptional regulator YP_002326601.1 [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation YP_002326603.1 [E] COG0405 gamma-glutamyltransferase YP_002326604.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326605.1 [M] COG0845 Membrane-fusion protein YP_002326606.1 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002326607.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002326608.1 [E] COG0665 glycine/D-amino acid oxidases (deaminating) YP_002326610.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326611.1 [O] COG1764 Predicted redox protein, regulator of disulfide bond formation YP_002326612.1 [L] COG0420 DNA repair exonuclease YP_002326613.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326614.1 similar to PA0394; [R] COG0325 Predicted enzyme with a TIM-barrel fold YP_002326615.1 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_002326616.1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF YP_002326617.1 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins YP_002326618.1 [J] COG2913 Small protein A (tmRNA-binding) YP_002326619.1 [S] COG2914 Uncharacterized protein conserved in bacteria YP_002326621.1 [P] COG2703 Hemerythrin YP_002326622.1 [R] COG0121 Predicted glutamine amidotransferase YP_002326623.1 [R] COG3176 hemolysin YP_002326624.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002326625.1 [G] COG1109 phosphomannomutase YP_002326626.1 catalyzes the formation of dUMP from dUTP YP_002326627.1 [L] COG0210 Superfamily I DNA and RNA helicases YP_002326628.1 [M] COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_002326629.1 [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002326631.1 [D] COG0850 Septum formation inhibitor YP_002326632.1 [D] COG3640 CO dehydrogenase maturation factor YP_002326633.1 [D] COG0851 Septum formation topological specificity factor YP_002326634.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326635.1 [E] COG1280 threonine efflux protein YP_002326636.1 [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002326637.1 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_002326638.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002326639.1 [O] COG2935 arginyl-tRNA:protein arginylyltransferase YP_002326640.1 [R] COG0456 acetyltransferases YP_002326641.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002326642.1 [R] COG3687 Predicted metal-dependent hydrolase YP_002326643.1 [J] COG0050 GTPases - translation elongation factors YP_002326644.1 [J] COG5256 translation elongation factor EF-1alpha (GTPase) YP_002326645.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002326646.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002326647.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002326649.1 [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase YP_002326650.1 [S] COG1981 Predicted membrane protein YP_002326651.1 [R] COG1741 Pirin-related protein YP_002326652.1 [S] COG4253 Uncharacterized protein conserved in bacteria YP_002326653.1 [H] COG0171 NAD synthase YP_002326655.1 [C] COG0633 Ferredoxin YP_002326656.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326657.1 [PR] COG4638 phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit YP_002326658.1 [I] COG0657 Esterase/lipase YP_002326659.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function YP_002326660.1 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase YP_002326661.1 [K] COG0583 transcriptional regulator YP_002326662.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326663.1 [C] COG1145 Ferredoxin YP_002326664.1 [H] COG0669 phosphopantetheine adenylyltransferase YP_002326665.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002326666.1 [R] COG0655 Multimeric flavodoxin WrbA YP_002326667.1 [S] COG1496 Uncharacterized conserved protein YP_002326668.1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific YP_002326669.1 [R] COG4105 DNA uptake lipoprotein YP_002326670.1 [L] COG0358 DNA primase (bacterial type) YP_002326671.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002326672.1 [R] COG0457 FOG: TPR repeat YP_002326673.1 [M] COG3017 outer membrane lipoprotein involved in outer membrane biogenesis YP_002326674.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002326675.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002326676.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002326677.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002326678.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002326679.1 [S] COG4929 Uncharacterized membrane-anchored protein YP_002326680.1 [C] COG1048 Aconitase A YP_002326681.1 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002326682.1 [R] COG0637 Predicted phosphatase/phosphohexomutase YP_002326683.1 [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase YP_002326684.1 [S] COG1652 Uncharacterized protein containing LysM domain YP_002326685.1 carries the fatty acid chain in fatty acid biosynthesis YP_002326686.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326687.1 [I] COG0331 (acyl-carrier-protein) S-malonyltransferase YP_002326688.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002326689.1 [R] COG1399 Predicted metal-binding, possibly nucleic acid-binding protein YP_002326690.1 [S] COG3101 Uncharacterized protein conserved in bacteria YP_002326691.1 [J] COG0009 translation factor (SUA5) YP_002326692.1 [S] COG1354 Uncharacterized conserved protein YP_002326693.1 [K] COG1386 Predicted transcriptional regulator containing the HTH domain YP_002326694.1 [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002326695.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326696.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002326697.1 [E] COG4992 Ornithine/acetylornithine aminotransferase YP_002326698.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326700.1 [G] COG1877 Trehalose-6-phosphatase YP_002326701.1 [G] COG0380 Trehalose-6-phosphate synthase YP_002326702.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326703.1 [P] COG2193 Bacterioferritin (cytochrome b1) YP_002326704.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326705.1 [D] COG3115 Cell division protein YP_002326706.1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_002326707.1 [K] COG1802 transcriptional regulators YP_002326708.1 [R] COG0730 Predicted permeases YP_002326709.1 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase YP_002326710.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_002326711.1 [N] COG1419 Flagellar GTP-binding protein YP_002326712.1 [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_002326713.1 [J] COG0042 tRNA-dihydrouridine synthase YP_002326715.1 [UW] COG5295 Autotransporter adhesin YP_002326718.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326719.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_002326720.1 [E] COG1280 threonine efflux protein YP_002326721.1 [S] COG3216 Uncharacterized protein conserved in bacteria YP_002326722.1 [F] COG0775 Nucleoside phosphorylase YP_002326723.1 [D] COG2894 Septum formation inhibitor-activating ATPase YP_002326724.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326725.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002326727.1 [E] COG1280 threonine efflux protein YP_002326728.1 [K] COG1309 transcriptional regulator YP_002326729.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326730.1 [M] COG0845 Membrane-fusion protein YP_002326731.1 [E] COG2515 1-aminocyclopropane-1-carboxylate deaminase YP_002326732.1 [O] COG0492 Thioredoxin reductase YP_002326734.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326737.1 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002326738.1 [K] COG0583 transcriptional regulator YP_002326740.1 [K] COG1278 Cold shock proteins YP_002326741.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002326742.1 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit YP_002326743.1 Catalyzes the transfer of electrons from NADH to quinone YP_002326744.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002326745.1 [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) YP_002326746.1 [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) YP_002326747.1 Catalyzes the transfer of electrons from NADH to quinone YP_002326748.1 Catalyzes the transfer of electrons from NADH to quinone YP_002326749.1 Catalyzes the transfer of electrons from NADH to quinone YP_002326750.1 [C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC YP_002326751.1 Catalyzes the transfer of electrons from NADH to quinone YP_002326752.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_002326753.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002326754.1 [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) YP_002326755.1 [T] COG2199 FOG: GGDEF domain YP_002326757.1 [T] COG0642 Signal transduction histidine kinase YP_002326758.1 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002326759.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002326761.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002326762.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326763.1 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog YP_002326764.1 [K] COG0583 transcriptional regulator YP_002326769.1 [K] COG1309 transcriptional regulator YP_002326770.1 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002326771.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_002326772.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326773.1 [K] COG0583 transcriptional regulator YP_002326775.1 [E] COG1280 threonine efflux protein YP_002326777.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326778.1 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_002326779.1 [I] COG2067 Long-chain fatty acid transport protein YP_002326780.1 [K] COG0583 transcriptional regulator YP_002326781.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326782.1 [P] COG0725 ABC-type molybdate transport system, periplasmic component YP_002326783.1 [K] COG0583 transcriptional regulator YP_002326784.1 catalyzes the oxidation of tricarballylate to cis-aconitate; FAD-dependent; required for the utilization of tricarballylate as a carbon and energy source by S. enterica YP_002326785.1 [C] COG0247 Fe-S oxidoreductase YP_002326786.1 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_002326787.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326788.1 similar to glutaryl-CoA dehydrogenase, mitochondrial precursor (GCD); [I] COG1960 acyl-CoA dehydrogenases YP_002326789.1 [K] COG0583 transcriptional regulator YP_002326790.1 L-iditol 2-dehydrogenase; glucitol dehydrogenase; [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_002326791.1 catalyzes the formation of inosine from adenosine YP_002326792.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002326793.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_002326794.1 [L] COG3695 Predicted methylated DNA-protein cysteine methyltransferase YP_002326795.1 [P] COG2076 Membrane transporters of cations and cationic drugs YP_002326796.1 [P] COG1230 Co/Zn/Cd efflux system component YP_002326797.1 [P] COG3667 Uncharacterized protein involved in copper resistance YP_002326798.1 [Q] COG2132 multicopper oxidases YP_002326800.1 [R] COG0561 Predicted hydrolases of the HAD superfamily YP_002326801.1 [G] COG0036 Pentose-5-phosphate-3-epimerase YP_002326802.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326803.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326804.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326805.1 [O] COG0533 Metal-dependent proteases with possible chaperone activity YP_002326806.1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_002326807.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002326808.1 similar to Nudix hydrolase 23, chloroplast precursor (AtNUDT23); [L] COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding YP_002326811.1 [I] COG2067 Long-chain fatty acid transport protein YP_002326812.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326813.1 [R] COG3271 Predicted double-glycine peptidase YP_002326814.1 [U] COG3210 Large exoproteins involved in heme utilization or adhesion YP_002326815.1 [HQ] COG1169 Isochorismate synthase YP_002326816.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002326817.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002326818.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_002326819.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002326820.1 [T] COG0271 Stress-induced morphogen (activity unknown) YP_002326821.1 [J] COG1544 ribosome-associated protein Y (PSrp-1) YP_002326822.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002326824.1 [M] COG2853 Surface lipoprotein YP_002326825.1 [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit YP_002326826.1 [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) YP_002326827.1 similar to sll0601; [R] COG0388 Predicted amidohydrolase YP_002326829.1 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase YP_002326830.1 Chain A, Crystal Structure Of Pseudomonas aeruginosa Ohr; [O] COG1764 Predicted redox protein, regulator of disulfide bond formation YP_002326831.1 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_002326833.1 [M] COG0668 Small-conductance mechanosensitive channel YP_002326834.1 [P] COG3256 nitric oxide reductase large subunit YP_002326835.1 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) YP_002326836.1 [S] COG0762 Predicted integral membrane protein YP_002326837.1 [E] COG0345 Pyrroline-5-carboxylate reductase YP_002326838.1 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_002326839.1 [I] COG4799 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_002326840.1 [FP] COG0248 Exopolyphosphatase YP_002326841.1 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins YP_002326842.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002326843.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326844.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002326845.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002326846.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002326849.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002326850.1 [J] COG0291 ribosomal protein L35 YP_002326851.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326852.1 [S] COG0586 Uncharacterized membrane-associated protein YP_002326853.1 [O] COG0625 glutathione S-transferase YP_002326854.1 [J] COG0290 translation initiation factor 3 (IF-3) YP_002326855.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002326856.1 activates fatty acids by binding to coenzyme A YP_002326857.1 [S] COG3028 Uncharacterized protein conserved in bacteria YP_002326858.1 [G] COG1925 phosphotransferase system, HPr-related proteins YP_002326859.1 [R] COG1660 Predicted P-loop-containing kinase YP_002326860.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002326861.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002326862.1 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_002326863.1 [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase YP_002326864.1 [K] COG2183 transcriptional accessory protein YP_002326865.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002326866.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326867.1 [S] COG2357 Uncharacterized protein conserved in bacteria YP_002326868.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002326869.1 [L] COG3298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB YP_002326870.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_002326871.1 [T] COG0642 Signal transduction histidine kinase YP_002326872.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002326873.1 [G] COG0362 6-phosphogluconate dehydrogenase YP_002326874.1 [G] COG3622 Hydroxypyruvate isomerase YP_002326875.1 [S] COG0799 Uncharacterized homolog of plant Iojap protein YP_002326876.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326877.1 [C] COG1282 NAD/NADP transhydrogenase beta subunit YP_002326878.1 [C] COG3288 NAD/NADP transhydrogenase alpha subunit YP_002326879.1 [E] COG0686 Alanine dehydrogenase YP_002326880.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002326881.1 [J] COG0251 translation initiation inhibitor, yjgF family YP_002326882.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002326883.1 [J] COG0042 tRNA-dihydrouridine synthase YP_002326884.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326885.1 [K] COG0583 transcriptional regulator YP_002326887.1 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 YP_002326888.1 [C] COG1048 Aconitase A YP_002326889.1 [L] COG0084 Mg-dependent DNase YP_002326890.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326892.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002326894.1 [K] COG1309 transcriptional regulator YP_002326896.1 [T] COG4943 Predicted signal transduction protein containing sensor and EAL domains YP_002326897.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002326898.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002326899.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_002326901.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002326902.1 [M] COG2980 Rare lipoprotein B YP_002326903.1 [L] COG1466 DNA polymerase III, delta subunit YP_002326904.1 [M] COG0845 Membrane-fusion protein YP_002326905.1 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_002326906.1 [MU] COG1538 outer membrane protein YP_002326907.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002326908.1 [S] COG4760 Predicted membrane protein YP_002326909.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002326910.1 [R] COG1162 Predicted GTPases YP_002326911.1 [P] COG0607 Rhodanese-related sulfurtransferase YP_002326912.1 [O] COG0695 glutaredoxin and related proteins YP_002326913.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002326914.1 [H] COG2091 phosphopantetheinyl transferase YP_002326915.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002326916.1 [S] COG1520 FOG: WD40-like repeat YP_002326917.1 similar to HI0370; [S] COG2976 Uncharacterized protein conserved in bacteria YP_002326918.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002326919.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002326920.1 [S] COG1426 Uncharacterized protein conserved in bacteria YP_002326921.1 [R] COG0457 FOG: TPR repeat YP_002326922.1 [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) YP_002326923.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002326924.1 [S] COG2975 Uncharacterized protein conserved in bacteria YP_002326925.1 [I] COG0671 Membrane-associated phospholipid phosphatase YP_002326926.1 [M] COG0438 glycosyltransferase YP_002326927.1 [M] COG0793 Periplasmic protease YP_002326928.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002326929.1 [Q] COG3315 O-methyltransferase involved in polyketide biosynthesis YP_002326930.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002326931.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002326932.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326933.1 [G] COG3265 gluconate kinase YP_002326934.1 [GE] COG2610 H+/gluconate symporter and related permeases YP_002326935.1 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_002326936.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002326937.1 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_002326938.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002326939.1 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain YP_002326941.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326942.1 binds and unfolds substrates as part of the ClpXP protease YP_002326943.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002326944.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002326945.1 [P] COG4771 outer membrane receptor for ferrienterochelin and colicins YP_002326946.1 [S] COG3128 Uncharacterized iron-regulated protein YP_002326947.1 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases YP_002326948.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_002326949.1 [QR] COG0500 SAM-dependent methyltransferases YP_002326950.1 [R] COG0790 FOG: TPR repeat, SEL1 subfamily YP_002326951.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002326952.1 [R] COG0679 Predicted permeases YP_002326953.1 [U] COG1826 Sec-independent protein secretion pathway components YP_002326954.1 [U] COG1826 Sec-independent protein secretion pathway components YP_002326955.1 [U] COG0805 Sec-independent protein secretion pathway component TatC YP_002326956.1 [R] COG3211 Predicted phosphatase YP_002326957.1 [R] COG3211 Predicted phosphatase YP_002326958.1 [S] COG3332 Uncharacterized conserved protein YP_002326959.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002326962.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002326963.1 [H] COG0262 Dihydrofolate reductase YP_002326964.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326965.1 [O] COG0225 peptide methionine sulfoxide reductase YP_002326966.1 [U] COG0848 biopolymer transport protein YP_002326967.1 [U] COG0811 biopolymer transport proteins YP_002326968.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326969.1 [J] COG0223 methionyl-tRNA formyltransferase YP_002326970.1 [K] COG1309 transcriptional regulator YP_002326971.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002326972.1 required for 70S ribosome assembly YP_002326973.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002326974.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002326976.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002326978.1 [R] COG0724 RNA-binding proteins (RRM domain) YP_002326979.1 [L] COG0210 Superfamily I DNA and RNA helicases YP_002326980.1 [S] COG3247 Uncharacterized conserved protein YP_002326982.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002326984.1 [K] COG1733 Predicted transcriptional regulators YP_002326985.1 [C] COG1062 Zn-dependent alcohol dehydrogenases, class III YP_002326987.1 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_002326988.1 [E] COG1280 threonine efflux protein YP_002326989.1 [M] COG1560 Lauroyl/myristoyl acyltransferase YP_002326990.1 [M] COG0438 glycosyltransferase YP_002326991.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_002326992.1 [S] COG3021 Uncharacterized protein conserved in bacteria YP_002326993.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002326994.1 [NU] COG3170 Tfp pilus assembly protein FimV YP_002326996.1 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D YP_002326997.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002326998.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002326999.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002327000.1 [S] COG3755 Uncharacterized protein conserved in bacteria YP_002327002.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002327004.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002327005.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002327007.1 [K] COG0583 transcriptional regulator YP_002327008.1 [E] COG0560 phosphoserine phosphatase YP_002327009.1 hydrolyzes diadenosine polyphosphate YP_002327010.1 [G] COG0574 phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002327011.1 [P] COG0376 Catalase (peroxidase I) YP_002327012.1 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_002327013.1 activator of 3-phenylpropionic acid catabolism YP_002327014.1 [S] COG4291 Predicted membrane protein YP_002327015.1 [O] COG0625 glutathione S-transferase YP_002327016.1 [K] COG2378 Predicted transcriptional regulator YP_002327017.1 [R] COG0637 Predicted phosphatase/phosphohexomutase YP_002327018.1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific YP_002327021.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327022.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization YP_002327023.1 [K] COG0583 transcriptional regulator YP_002327024.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002327025.1 [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases YP_002327026.1 [S] COG3238 Uncharacterized protein conserved in bacteria YP_002327027.1 [V] COG0534 Na+-driven multidrug efflux pump YP_002327028.1 [I] COG1960 acyl-CoA dehydrogenases YP_002327029.1 [I] COG1960 acyl-CoA dehydrogenases YP_002327030.1 [R] COG0661 Predicted unusual protein kinase YP_002327031.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002327033.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002327034.1 [S] COG3791 Uncharacterized conserved protein YP_002327035.1 [R] COG2081 Predicted flavoproteins YP_002327036.1 [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase YP_002327037.1 [S] COG3024 Uncharacterized protein conserved in bacteria YP_002327038.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002327039.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002327041.1 [M] COG0796 glutamate racemase YP_002327042.1 [S] COG3816 Uncharacterized protein conserved in bacteria YP_002327043.1 similar to Electron transfer flavoprotein-ubiquinone oxidoreductase,mitochondrial precursor(ETF-QO); [C] COG0644 Dehydrogenases (flavoproteins) YP_002327045.1 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation YP_002327046.1 [R] COG1253 Hemolysins and related proteins containing CBS domains YP_002327047.1 [M] COG0815 Apolipoprotein N-acyltransferase YP_002327048.1 [R] COG0073 EMAP domain YP_002327050.1 [NU] COG4969 Tfp pilus assembly protein, major pilin PilA YP_002327051.1 [NU] COG1459 Type II secretory pathway, component PulF YP_002327052.1 [LK] COG1200 RecG-like helicase YP_002327053.1 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_002327054.1 [O] COG1281 Disulfide bond chaperones of the HSP33 family YP_002327055.1 [E] COG1280 threonine efflux protein YP_002327056.1 [O] COG2214 DnaJ-class molecular chaperone YP_002327058.1 [P] COG0598 Mg2+ and Co2+ transporters YP_002327059.1 [J] COG0539 ribosomal protein S1 YP_002327060.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002327061.1 [V] COG1680 beta-lactamase class C and other penicillin binding proteins YP_002327062.1 [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_002327063.1 [L] COG0210 Superfamily I DNA and RNA helicases YP_002327064.1 [L] COG1330 Exonuclease V gamma subunit YP_002327065.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327066.1 [S] COG2326 Uncharacterized conserved protein YP_002327068.1 [QR] COG0500 SAM-dependent methyltransferases YP_002327069.1 [S] COG3165 Uncharacterized protein conserved in bacteria YP_002327070.1 [R] COG0661 Predicted unusual protein kinase YP_002327071.1 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_002327072.1 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_002327073.1 [E] COG0139 phosphoribosyl-AMP cyclohydrolase YP_002327074.1 [L] COG0210 Superfamily I DNA and RNA helicases YP_002327075.1 [R] COG3950 Predicted ATP-binding protein involved in virulence YP_002327076.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_002327077.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002327078.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002327079.1 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit YP_002327080.1 [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit YP_002327081.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002327082.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002327083.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002327084.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002327085.1 [S] COG0779 Uncharacterized protein conserved in bacteria YP_002327086.1 [U] COG1314 Preprotein translocase subunit SecG YP_002327087.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002327088.1 [U] COG4962 Flp pilus assembly protein, ATPase CpaF YP_002327089.1 [NU] COG1459 Type II secretory pathway, component PulF YP_002327090.1 [NU] COG1459 Type II secretory pathway, component PulF YP_002327091.1 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases YP_002327092.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002327093.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002327094.1 [J] COG0219 Predicted rRNA methylase (SpoU class) YP_002327095.1 [S] COG3123 Uncharacterized protein conserved in bacteria YP_002327097.1 [L] COG0419 ATPase involved in DNA repair YP_002327098.1 [K] COG1678 transcriptional regulator YP_002327099.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002327100.1 [M] COG0845 Membrane-fusion protein YP_002327101.1 [S] COG1289 Predicted membrane protein YP_002327102.1 [K] COG1414 transcriptional regulator YP_002327103.1 [L] COG3145 Alkylated DNA repair protein YP_002327104.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002327105.1 [I] COG0558 phosphatidylglycerophosphate synthase YP_002327106.1 [I] COG1946 acyl-CoA thioesterase YP_002327107.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002327108.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327109.1 [O] COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases YP_002327111.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002327112.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002327114.1 [R] COG3545 Predicted esterase of the alpha/beta hydrolase fold YP_002327115.1 [K] COG0789 Predicted transcriptional regulators YP_002327117.1 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis YP_002327120.1 molecular chaperone YP_002327121.1 [S] COG4461 Uncharacterized protein conserved in bacteria, lipoprotein YP_002327122.1 [M] COG3047 outer membrane protein W YP_002327123.1 [GE] COG2610 H+/gluconate symporter and related permeases YP_002327124.1 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002327125.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327126.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327127.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327128.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002327129.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002327130.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002327131.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002327132.1 in Escherichia coli and methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002327133.1 binds directly to 23S ribosomal RNA YP_002327134.1 [K] COG0250 transcription antiterminator YP_002327135.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002327136.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002327137.1 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I YP_002327138.1 [R] COG0637 Predicted phosphatase/phosphohexomutase YP_002327139.1 [T] COG1716 FOG: FHA domain YP_002327140.1 [NU] COG1450 Type II secretory pathway, component PulD YP_002327141.1 [U] COG3031 Type II secretory pathway, component PulC YP_002327142.1 [R] COG2916 DNA-binding protein H-NS YP_002327143.1 [R] COG0824 Predicted thioesterase YP_002327146.1 [H] COG1587 Uroporphyrinogen-III synthase YP_002327147.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002327148.1 [T] COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain YP_002327149.1 [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain YP_002327150.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002327151.1 [CO] COG2924 Fe-S cluster protector protein YP_002327152.1 [P] COG0704 phosphate uptake regulator YP_002327153.1 [MU] COG1538 outer membrane protein YP_002327154.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002327155.1 [K] COG1309 transcriptional regulator YP_002327156.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327157.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002327158.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002327159.1 [R] COG1409 Predicted phosphohydrolases YP_002327160.1 [T] COG1734 DnaK suppressor protein YP_002327161.1 [J] COG0008 glutamyl- and glutaminyl-tRNA synthetases YP_002327162.1 [D] COG0772 Bacterial cell division membrane protein YP_002327163.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002327165.1 [R] COG1159 GTPase YP_002327166.1 [P] COG1918 Fe2+ transport system protein A YP_002327167.1 [L] COG0582 Integrase YP_002327168.1 [O] COG1651 protein-disulfide isomerase YP_002327169.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002327170.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002327171.1 [M] COG1686 D-alanyl-D-alanine carboxypeptidase YP_002327172.1 [E] COG0531 amino acid transporters YP_002327173.1 [T] COG0642 Signal transduction histidine kinase YP_002327174.1 [KT] COG3604 transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains YP_002327175.1 [M] COG0793 Periplasmic protease YP_002327176.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002327177.1 [R] COG0795 Predicted permeases YP_002327178.1 [R] COG0795 Predicted permeases YP_002327179.1 [R] COG0795 Predicted permeases YP_002327180.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002327181.1 [L] COG2927 DNA polymerase III, chi subunit YP_002327184.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002327185.1 [L] COG3392 Adenine-specific DNA methylase YP_002327186.1 [J] COG0049 ribosomal protein S7 YP_002327187.1 [K] COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_002327188.1 [P] COG0004 Ammonia permease YP_002327189.1 [J] COG0223 methionyl-tRNA formyltransferase YP_002327190.1 [S] COG2960 Uncharacterized protein conserved in bacteria YP_002327191.1 [O] COG0466 ATP-dependent Lon protease, bacterial type YP_002327192.1 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_002327193.1 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_002327194.1 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_002327195.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327197.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327198.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002327199.1 [S] COG3686 Predicted membrane protein YP_002327201.1 [IQ] COG0318 acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002327202.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002327203.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002327204.1 [S] COG2860 Predicted membrane protein YP_002327205.1 [S] COG3012 Uncharacterized protein conserved in bacteria YP_002327206.1 [P] COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_002327207.1 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein YP_002327208.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002327209.1 [M] COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_002327210.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002327211.1 [J] COG0251 translation initiation inhibitor, yjgF family YP_002327213.1 [C] COG1032 Fe-S oxidoreductase YP_002327214.1 [S] COG4222 Uncharacterized protein conserved in bacteria YP_002327215.1 [K] COG0789 Predicted transcriptional regulators YP_002327216.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327217.1 [R] COG0655 Multimeric flavodoxin WrbA YP_002327218.1 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002327219.1 [E] COG0498 Threonine synthase YP_002327220.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327223.1 [K] COG1309 transcriptional regulator YP_002327224.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327226.1 [P] COG1629 outer membrane receptor proteins, mostly Fe transport YP_002327228.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002327229.1 [S] COG1652 Uncharacterized protein containing LysM domain YP_002327230.1 [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_002327231.1 [J] COG0009 translation factor (SUA5) YP_002327232.1 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_002327233.1 [K] COG1309 transcriptional regulator YP_002327234.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002327235.1 [K] COG2207 AraC-type DNA-binding domain-containing proteins YP_002327236.1 [O] COG0386 glutathione peroxidase YP_002327238.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002327239.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the beta chain is a regulatory subunit YP_002327240.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002327241.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002327242.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002327243.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002327244.1 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K YP_002327245.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002327246.1 [C] COG3312 F0F1-type ATP synthase, subunit I YP_002327247.1 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin YP_002327248.1 [J] COG0216 protein chain release factor A YP_002327249.1 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component YP_002327250.1 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components YP_002327251.1 [E] COG1280 threonine efflux protein YP_002327252.1 [P] COG2837 Predicted iron-dependent peroxidase YP_002327253.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002327254.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002327255.1 [D] COG3087 Cell division protein YP_002327256.1 [O] COG0625 glutathione S-transferase YP_002327257.1 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation YP_002327258.1 [R] COG1741 Pirin-related protein YP_002327259.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327260.1 [K] COG1695 Predicted transcriptional regulators YP_002327261.1 [R] COG1708 Predicted nucleotidyltransferases YP_002327262.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002327263.1 [S] COG4399 Uncharacterized protein conserved in bacteria YP_002327264.1 [S] COG2259 Predicted membrane protein YP_002327265.1 [S] COG0586 Uncharacterized membrane-associated protein YP_002327266.1 [E] COG1280 threonine efflux protein YP_002327268.1 [D] COG1192 ATPases involved in chromosome partitioning YP_002327270.1 [T] COG0271 Stress-induced morphogen (activity unknown) YP_002327271.1 [H] COG2091 phosphopantetheinyl transferase YP_002327272.1 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases YP_002327274.1 [R] COG2409 Predicted drug exporters of the RND superfamily YP_002327275.1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins YP_002327276.1 [Q] COG3321 polyketide synthase modules and related proteins YP_002327277.1 [I] COG1960 acyl-CoA dehydrogenases YP_002327278.1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins YP_002327279.1 [TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002327281.1 [TQ] COG3916 N-acyl-L-homoserine lactone synthetase YP_002327282.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002327283.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002327284.1 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase YP_002327285.1 [I] COG1960 acyl-CoA dehydrogenases YP_002327286.1 [I] COG0365 acyl-coenzyme A synthetases/AMP-(fatty) acid ligases YP_002327287.1 [G] COG0362 6-phosphogluconate dehydrogenase YP_002327288.1 [C] COG1012 NAD-dependent aldehyde dehydrogenases YP_002327289.1 [K] COG0583 transcriptional regulator YP_002327290.1 [E] COG0833 amino acid transporters YP_002327291.1 [E] COG0833 amino acid transporters YP_002327292.1 [J] COG0251 translation initiation inhibitor, yjgF family YP_002327293.1 [M] COG0787 Alanine racemase YP_002327294.1 catalyzes the oxidative deamination of D-amino acids YP_002327295.1 [K] COG1522 transcriptional regulators YP_002327296.1 [S] COG3503 Predicted membrane protein YP_002327297.1 [P] COG4771 outer membrane receptor for ferrienterochelin and colicins YP_002327298.1 [S] COG4922 Uncharacterized protein conserved in bacteria YP_002327299.1 [S] COG3076 Uncharacterized protein conserved in bacteria YP_002327300.1 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific YP_002327301.1 [S] COG4420 Predicted membrane protein YP_002327302.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002327305.1 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002327306.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327309.1 Catalyzes the conversion of citrate to isocitrate YP_002327310.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_002327311.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_002327312.1 [K] COG2186 transcriptional regulators YP_002327313.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002327314.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_002327315.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_002327316.1 represses the lctPRD operon YP_002327317.1 [C] COG1620 L-lactate permease YP_002327318.1 [G] COG1109 phosphomannomutase YP_002327319.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002327320.1 [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase YP_002327321.1 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) YP_002327322.1 [M] COG1088 dTDP-D-glucose 4,6-dehydratase YP_002327323.1 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_002327324.1 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_002327325.1 [M] COG0438 glycosyltransferase YP_002327327.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327328.1 [GEPR] COG0477 Permeases of the major facilitator superfamily YP_002327329.1 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases YP_002327330.1 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase YP_002327331.1 [M] COG1596 Periplasmic protein involved in polysaccharide export YP_002327332.1 [T] COG0394 protein-tyrosine-phosphatase YP_002327333.1 [D] COG0455 ATPases involved in chromosome partitioning YP_002327334.1 [O] COG0545 peptidyl-prolyl cis-trans isomerases 1 YP_002327335.1 [O] COG0545 peptidyl-prolyl cis-trans isomerases 1 YP_002327336.1 [V] COG0534 Na+-driven multidrug efflux pump YP_002327337.1 [V] COG3023 Negative regulator of beta-lactamase expression YP_002327338.1 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase YP_002327339.1 [M] COG3511 phospholipase C YP_002327341.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002327342.1 [I] COG3239 Fatty acid desaturase YP_002327343.1 [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_002327344.1 [K] COG1309 transcriptional regulator YP_002327345.1 [K] COG1309 transcriptional regulator YP_002327346.1 [O] COG1651 protein-disulfide isomerase YP_002327347.1 Involved in ubiquinone biosynthesis YP_002327348.1 [R] COG0637 Predicted phosphatase/phosphohexomutase YP_002327349.1 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002327350.1 [S] COG5455 Predicted integral membrane protein YP_002327352.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002327353.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002327354.1 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components YP_002327355.1 catalyzes the release of sulfite from alkanesulfonates YP_002327356.1 [E] COG4176 ABC-type proline/glycine betaine transport system, permease component YP_002327357.1 [E] COG3842 ABC-type spermidine/putrescine transport systems, ATPase components YP_002327358.1 [K] COG1309 transcriptional regulator YP_002327359.1 [F] COG0775 Nucleoside phosphorylase YP_002327360.1 [P] COG1275 Tellurite resistance protein and related permeases YP_002327361.1 [H] COG0196 FAD synthase YP_002327362.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002327363.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002327364.1 [O] COG0545 peptidyl-prolyl cis-trans isomerases 1 YP_002327365.1 [R] COG0431 Predicted flavoprotein YP_002327366.1 [R] COG0666 FOG: Ankyrin repeat YP_002327368.1 [O] COG0652 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_002327369.1 similar to Chain A, Carboxylesterase Est2 From Alicyclobacillus Acidocaldarius; [I] COG0657 Esterase/lipase YP_002327370.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327372.1 [R] COG0491 Zn-dependent hydrolases, including glyoxylases YP_002327373.1 [K] COG0583 transcriptional regulator YP_002327374.1 [O] COG0576 Molecular chaperone GrpE (heat shock protein) YP_002327375.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002327377.1 [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit YP_002327379.1 [M] COG2951 Membrane-bound lytic murein transglycosylase B YP_002327380.1 [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) YP_002327381.1 [C] COG0437 Fe-S-cluster-containing hydrogenase components 1 YP_002327382.1 [S] COG3169 Uncharacterized protein conserved in bacteria YP_002327383.1 [M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase YP_002327384.1 [S] COG4292 Predicted membrane protein YP_002327385.1 [I] COG0671 Membrane-associated phospholipid phosphatase YP_002327386.1 [P] COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_002327388.1 [E] COG0754 glutathionylspermidine synthase YP_002327389.1 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases YP_002327390.1 Catalyzes the deamination of guanine YP_002327392.1 [R] COG2236 Predicted phosphoribosyltransferases YP_002327393.1 [S] COG2261 Predicted membrane protein YP_002327394.1 [O] COG1651 protein-disulfide isomerase YP_002327395.1 [R] COG0523 GTPases (G3E family) YP_002327396.1 [S] COG1937 Uncharacterized protein conserved in bacteria YP_002327397.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002327398.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002327399.1 [S] COG0759 Uncharacterized conserved protein YP_002327400.1 [J] COG0594 RNase P protein component YP_002327401.1 in Escherichia coli transcription of this gene is enhanced by polyamines