-- dump date 20120504_131903 -- class Genbank::misc_feature -- table misc_feature_note -- id note 509170000001 Initiator Replication protein; Region: Rep_3; cl03080 509170000002 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 509170000003 active site 509170000004 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000005 Initiator Replication protein; Region: Rep_3; cl03080 509170000006 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000007 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000008 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170000009 putative peptidoglycan binding site; other site 509170000010 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 509170000011 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 509170000012 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000014 Evidence 7 : Gene remnant; Product type f : factor; fragment of DNA replication protein 509170000015 HpaII restriction endonuclease; Region: RE_HpaII; pfam09561 509170000016 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 509170000017 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 509170000018 cofactor binding site; other site 509170000019 DNA binding site [nucleotide binding] 509170000020 substrate interaction site [chemical binding]; other site 509170000021 Evidence 7 : Gene remnant; Product type pf : putative factor; putative fragment of mobilization protein (MobL-like) 509170000022 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000023 Initiator Replication protein; Region: Rep_3; cl03080 509170000024 MobA/MobL family; Region: MobA_MobL; pfam03389 509170000025 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 509170000026 RelB antitoxin; Region: RelB; cl01171 509170000027 PAAR motif; Region: PAAR_motif; cl15808 509170000028 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 509170000029 Initiator Replication protein; Region: Rep_3; cl03080 509170000030 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 509170000031 catalytic residue [active] 509170000032 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170000033 Initiator Replication protein; Region: Rep_3; cl03080 509170000034 MobA/MobL family; Region: MobA_MobL; pfam03389 509170000035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 509170000038 Catalytic domain of type IIs restriction endonuclease BfiI and similar proteins; Region: PLDc_Bfil; cd09175 509170000039 homodimer interface [polypeptide binding]; other site 509170000040 putative active site [active] 509170000041 catalytic site [active] 509170000042 C-terminal domain of type IIs restriction endonuclease BfiI and similar proteins; Region: BfiI_C; cd10018 509170000043 putative DNA binding site [nucleotide binding]; other site 509170000044 Transposase domain (DUF772); Region: DUF772; cl15789 509170000045 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000046 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 509170000047 Initiator Replication protein; Region: Rep_3; cl03080 509170000048 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170000049 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 509170000050 DNA-binding site [nucleotide binding]; DNA binding site 509170000051 RNA-binding motif; other site 509170000052 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000053 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000054 hydroperoxidase II; Provisional; Region: katE; PRK11249 509170000055 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 509170000056 heme binding pocket [chemical binding]; other site 509170000057 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 509170000058 domain interactions; other site 509170000059 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 509170000060 conserved cys residue [active] 509170000061 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 509170000062 DnaA N-terminal domain; Region: DnaA_N; pfam11638 509170000063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170000064 Walker A motif; other site 509170000065 ATP binding site [chemical binding]; other site 509170000066 Walker B motif; other site 509170000067 arginine finger; other site 509170000068 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 509170000069 DnaA box-binding interface [nucleotide binding]; other site 509170000070 DNA polymerase III subunit beta; Validated; Region: PRK05643 509170000071 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 509170000072 putative DNA binding surface [nucleotide binding]; other site 509170000073 dimer interface [polypeptide binding]; other site 509170000074 beta-clamp/clamp loader binding surface; other site 509170000075 beta-clamp/translesion DNA polymerase binding surface; other site 509170000076 recombination protein F; Reviewed; Region: recF; PRK00064 509170000077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000078 Walker A/P-loop; other site 509170000079 ATP binding site [chemical binding]; other site 509170000080 Q-loop/lid; other site 509170000081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000082 ABC transporter signature motif; other site 509170000083 Walker B; other site 509170000084 D-loop; other site 509170000085 H-loop/switch region; other site 509170000086 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 509170000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170000088 Mg2+ binding site [ion binding]; other site 509170000089 G-X-G motif; other site 509170000090 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 509170000091 anchoring element; other site 509170000092 dimer interface [polypeptide binding]; other site 509170000093 ATP binding site [chemical binding]; other site 509170000094 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 509170000095 active site 509170000096 putative metal-binding site [ion binding]; other site 509170000097 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509170000098 Cytochrome b562; Region: Cytochrom_B562; cl01546 509170000099 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170000100 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 509170000101 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000102 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000103 ABC transporter; Region: ABC_tran_2; pfam12848 509170000104 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000105 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000106 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 509170000107 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 509170000108 Evidence 7 : Gene remnant 509170000109 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000110 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000112 Transposase domain (DUF772); Region: DUF772; cl15789 509170000113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000114 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000115 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 509170000116 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 509170000117 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 509170000118 active site 509170000119 HIGH motif; other site 509170000120 dimer interface [polypeptide binding]; other site 509170000121 KMSKS motif; other site 509170000122 Transposase domain (DUF772); Region: DUF772; cl15789 509170000123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000124 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509170000125 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 509170000126 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 509170000127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170000128 active site 509170000129 HIGH motif; other site 509170000130 nucleotide binding site [chemical binding]; other site 509170000131 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170000132 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 509170000133 active site 509170000134 KMSKS motif; other site 509170000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 509170000136 tRNA binding surface [nucleotide binding]; other site 509170000137 anticodon binding site; other site 509170000138 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509170000139 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 509170000140 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 509170000141 active site 509170000142 Riboflavin kinase; Region: Flavokinase; cl03312 509170000143 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 509170000144 gating phenylalanine in ion channel; other site 509170000145 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509170000146 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 509170000147 Helix-turn-helix domains; Region: HTH; cl00088 509170000148 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 509170000149 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 509170000150 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 509170000151 Walker A/P-loop; other site 509170000152 ATP binding site [chemical binding]; other site 509170000153 Q-loop/lid; other site 509170000154 ABC transporter signature motif; other site 509170000155 Walker B; other site 509170000156 D-loop; other site 509170000157 H-loop/switch region; other site 509170000158 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 509170000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170000160 putative PBP binding loops; other site 509170000161 dimer interface [polypeptide binding]; other site 509170000162 ABC-ATPase subunit interface; other site 509170000163 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 509170000164 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509170000165 active site 509170000166 dimer interface [polypeptide binding]; other site 509170000167 non-prolyl cis peptide bond; other site 509170000168 insertion regions; other site 509170000169 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 509170000170 Transposase domain (DUF772); Region: DUF772; cl15789 509170000171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000172 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509170000174 substrate binding pocket [chemical binding]; other site 509170000175 membrane-bound complex binding site; other site 509170000176 hinge residues; other site 509170000177 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 509170000178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 509170000179 substrate binding pocket [chemical binding]; other site 509170000180 membrane-bound complex binding site; other site 509170000181 N-acetylglutamate synthase; Validated; Region: PRK05279 509170000182 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 509170000183 putative feedback inhibition sensing region; other site 509170000184 putative nucleotide binding site [chemical binding]; other site 509170000185 putative substrate binding site [chemical binding]; other site 509170000186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000187 Coenzyme A binding pocket [chemical binding]; other site 509170000188 Transposase domain (DUF772); Region: DUF772; cl15789 509170000189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000190 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 509170000191 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 509170000192 short chain dehydrogenase; Provisional; Region: PRK08703 509170000193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000194 NAD(P) binding site [chemical binding]; other site 509170000195 active site 509170000196 phosphoglycolate phosphatase; Provisional; Region: PRK13222 509170000197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170000198 active site 509170000199 motif I; other site 509170000200 motif II; other site 509170000201 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 509170000202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170000203 S-adenosylmethionine binding site [chemical binding]; other site 509170000204 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 509170000205 catalytic residues [active] 509170000206 hinge region; other site 509170000207 alpha helical domain; other site 509170000208 Helix-turn-helix domains; Region: HTH; cl00088 509170000209 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 509170000210 Helix-turn-helix domains; Region: HTH; cl00088 509170000211 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 509170000212 FMN reductase; Validated; Region: fre; PRK08051 509170000213 FAD binding pocket [chemical binding]; other site 509170000214 FAD binding motif [chemical binding]; other site 509170000215 phosphate binding motif [ion binding]; other site 509170000216 beta-alpha-beta structure motif; other site 509170000217 NAD binding pocket [chemical binding]; other site 509170000218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170000219 catalytic loop [active] 509170000220 iron binding site [ion binding]; other site 509170000221 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 509170000222 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 509170000223 putative di-iron ligands [ion binding]; other site 509170000224 ribonuclease PH; Reviewed; Region: rph; PRK00173 509170000225 Ribonuclease PH; Region: RNase_PH_bact; cd11362 509170000226 hexamer interface [polypeptide binding]; other site 509170000227 active site 509170000228 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 509170000229 Phosphoesterase family; Region: Phosphoesterase; cl15450 509170000230 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170000231 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170000232 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000233 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 509170000234 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 509170000235 dimerization interface [polypeptide binding]; other site 509170000236 active site 509170000237 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 509170000238 amidase catalytic site [active] 509170000239 Zn binding residues [ion binding]; other site 509170000240 substrate binding site [chemical binding]; other site 509170000241 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000243 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 509170000244 Transposase domain (DUF772); Region: DUF772; cl15789 509170000245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000246 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509170000247 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509170000248 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509170000249 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 509170000250 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 509170000251 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509170000252 tyrosine kinase; Provisional; Region: PRK11519 509170000253 Chain length determinant protein; Region: Wzz; cl15801 509170000254 Chain length determinant protein; Region: Wzz; cl15801 509170000255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000257 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509170000258 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 509170000259 active site 509170000260 polysaccharide export protein Wza; Provisional; Region: PRK15078 509170000261 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 509170000262 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 509170000263 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509170000264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000265 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 509170000266 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 509170000267 NAD(P) binding site [chemical binding]; other site 509170000268 homodimer interface [polypeptide binding]; other site 509170000269 substrate binding site [chemical binding]; other site 509170000270 active site 509170000271 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 509170000272 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 509170000273 inhibitor-cofactor binding pocket; inhibition site 509170000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000275 catalytic residue [active] 509170000276 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 509170000277 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 509170000278 active site 509170000279 homodimer interface [polypeptide binding]; other site 509170000280 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 509170000281 NeuB family; Region: NeuB; cl00496 509170000282 SAF domain; Region: SAF; cl00555 509170000283 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 509170000284 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 509170000285 putative trimer interface [polypeptide binding]; other site 509170000286 putative CoA binding site [chemical binding]; other site 509170000287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 509170000288 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 509170000289 Substrate binding site; other site 509170000290 metal-binding site 509170000291 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 509170000292 ligand binding site; other site 509170000293 tetramer interface; other site 509170000294 MatE; Region: MatE; cl10513 509170000295 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 509170000296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170000297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170000298 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 509170000299 putative ADP-binding pocket [chemical binding]; other site 509170000300 Bacterial sugar transferase; Region: Bac_transf; cl00939 509170000301 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 509170000302 active site 509170000303 tetramer interface; other site 509170000304 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 509170000305 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 509170000306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000307 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 509170000308 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 509170000309 active site 509170000310 dimer interface [polypeptide binding]; other site 509170000311 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 509170000312 dimer interface [polypeptide binding]; other site 509170000313 active site 509170000314 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 509170000315 UDP-glucose 4-epimerase; Region: PLN02240 509170000316 NAD binding site [chemical binding]; other site 509170000317 homodimer interface [polypeptide binding]; other site 509170000318 active site 509170000319 substrate binding site [chemical binding]; other site 509170000320 phosphomannomutase CpsG; Provisional; Region: PRK15414 509170000321 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509170000322 active site 509170000323 substrate binding site [chemical binding]; other site 509170000324 metal binding site [ion binding]; metal-binding site 509170000325 Evidence 7 : Gene remnant; Product type t : transporter; fragment of L-lactate permease (part 1) 509170000326 Evidence 7 : Gene remnant; Product type t : transporter; fragment of L-lactate permease (part 2) 509170000327 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 509170000328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170000329 DNA-binding site [nucleotide binding]; DNA binding site 509170000330 FCD domain; Region: FCD; cl11656 509170000331 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 509170000332 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509170000333 phosphate binding site [ion binding]; other site 509170000334 D-lactate dehydrogenase; Provisional; Region: PRK11183 509170000335 FAD binding domain; Region: FAD_binding_4; pfam01565 509170000336 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 509170000337 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 509170000338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170000339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000340 homodimer interface [polypeptide binding]; other site 509170000341 catalytic residue [active] 509170000342 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509170000343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170000344 DNA-binding site [nucleotide binding]; DNA binding site 509170000345 FCD domain; Region: FCD; cl11656 509170000346 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 509170000347 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 509170000348 tetramer interface [polypeptide binding]; other site 509170000349 active site 509170000350 Mg2+/Mn2+ binding site [ion binding]; other site 509170000351 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 509170000352 Citrate synthase; Region: Citrate_synt; pfam00285 509170000353 oxalacetate binding site [chemical binding]; other site 509170000354 citrylCoA binding site [chemical binding]; other site 509170000355 coenzyme A binding site [chemical binding]; other site 509170000356 catalytic triad [active] 509170000357 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 509170000358 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 509170000359 substrate binding site [chemical binding]; other site 509170000360 ligand binding site [chemical binding]; other site 509170000361 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 509170000362 substrate binding site [chemical binding]; other site 509170000363 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 509170000364 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 509170000365 Predicted acetyltransferase [General function prediction only]; Region: COG3981 509170000366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000367 Coenzyme A binding pocket [chemical binding]; other site 509170000368 Transposase domain (DUF772); Region: DUF772; cl15789 509170000369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000370 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000372 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000373 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000374 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000376 NAD(P) binding site [chemical binding]; other site 509170000377 active site 509170000378 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 509170000379 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000380 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000381 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 509170000382 active site 509170000383 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 509170000384 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 509170000385 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 509170000386 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170000387 N-terminal plug; other site 509170000388 ligand-binding site [chemical binding]; other site 509170000389 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 509170000390 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170000391 Helix-turn-helix domains; Region: HTH; cl00088 509170000392 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 509170000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170000394 mRNA stabilisation; Region: mRNA_stabil; pfam13929 509170000395 alanine racemase; Reviewed; Region: dadX; PRK03646 509170000396 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 509170000397 active site 509170000398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170000399 substrate binding site [chemical binding]; other site 509170000400 catalytic residues [active] 509170000401 dimer interface [polypeptide binding]; other site 509170000402 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 509170000403 homotrimer interaction site [polypeptide binding]; other site 509170000404 putative active site [active] 509170000405 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 509170000406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170000407 Helix-turn-helix domains; Region: HTH; cl00088 509170000408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170000409 dimerization interface [polypeptide binding]; other site 509170000410 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 509170000411 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170000412 tetrameric interface [polypeptide binding]; other site 509170000413 NAD binding site [chemical binding]; other site 509170000414 catalytic residues [active] 509170000415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000416 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 509170000417 acetyl-CoA synthetase; Provisional; Region: PRK04319 509170000418 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 509170000419 AMP-binding enzyme; Region: AMP-binding; cl15778 509170000420 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170000421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170000422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170000423 active site 509170000424 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enoyl-CoA hydratase/isomerase (part 1) 509170000425 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enoyl-CoA hydratase/isomerase (part 2) 509170000426 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 509170000427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170000428 substrate binding site [chemical binding]; other site 509170000429 oxyanion hole (OAH) forming residues; other site 509170000430 trimer interface [polypeptide binding]; other site 509170000431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 509170000432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000433 metabolite-proton symporter; Region: 2A0106; TIGR00883 509170000434 putative substrate translocation pore; other site 509170000435 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of N-acylhomoserine lactone synthase, autoinducer synthesis protein 509170000436 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000438 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of 4'-phosphopantetheinyl transferase (partial) 509170000439 BolA-like protein; Region: BolA; cl00386 509170000440 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 509170000441 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170000442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000443 P-loop; other site 509170000444 Magnesium ion binding site [ion binding]; other site 509170000445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000446 Magnesium ion binding site [ion binding]; other site 509170000447 LysE type translocator; Region: LysE; cl00565 509170000448 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170000449 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000450 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000451 DoxX; Region: DoxX; cl00976 509170000452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 509170000453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 509170000454 GMP synthase; Reviewed; Region: guaA; PRK00074 509170000455 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 509170000456 AMP/PPi binding site [chemical binding]; other site 509170000457 candidate oxyanion hole; other site 509170000458 catalytic triad [active] 509170000459 potential glutamine specificity residues [chemical binding]; other site 509170000460 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 509170000461 ATP Binding subdomain [chemical binding]; other site 509170000462 Ligand Binding sites [chemical binding]; other site 509170000463 Dimerization subdomain; other site 509170000464 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509170000465 active site 509170000466 NTP binding site [chemical binding]; other site 509170000467 metal binding triad [ion binding]; metal-binding site 509170000468 antibiotic binding site [chemical binding]; other site 509170000469 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 509170000470 Helix-turn-helix domains; Region: HTH; cl00088 509170000471 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 509170000472 Pirin-related protein [General function prediction only]; Region: COG1741 509170000473 Cupin domain; Region: Cupin_2; cl09118 509170000474 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509170000475 OsmC-like protein; Region: OsmC; cl00767 509170000476 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of glutathione S-transferase (part 1) 509170000477 Transposase domain (DUF772); Region: DUF772; cl15789 509170000478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000479 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of glutathione S-transferase (part 2) 509170000480 Sporulation related domain; Region: SPOR; cl10051 509170000481 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 509170000482 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 509170000483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170000484 active site 509170000485 HIGH motif; other site 509170000486 nucleotide binding site [chemical binding]; other site 509170000487 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 509170000488 KMSK motif region; other site 509170000489 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 509170000490 tRNA binding surface [nucleotide binding]; other site 509170000491 anticodon binding site; other site 509170000492 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 509170000495 ABC-ATPase subunit interface; other site 509170000496 dimer interface [polypeptide binding]; other site 509170000497 putative PBP binding regions; other site 509170000498 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 509170000499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000500 Walker A/P-loop; other site 509170000501 ATP binding site [chemical binding]; other site 509170000502 Q-loop/lid; other site 509170000503 ABC transporter signature motif; other site 509170000504 Walker B; other site 509170000505 D-loop; other site 509170000506 H-loop/switch region; other site 509170000507 Helix-turn-helix domains; Region: HTH; cl00088 509170000508 metal binding site 2 [ion binding]; metal-binding site 509170000509 putative DNA binding helix; other site 509170000510 metal binding site 1 [ion binding]; metal-binding site 509170000511 dimer interface [polypeptide binding]; other site 509170000512 structural Zn2+ binding site [ion binding]; other site 509170000513 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509170000514 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 509170000515 intersubunit interface [polypeptide binding]; other site 509170000516 ATP synthase I chain; Region: ATP_synt_I; cl09170 509170000517 ATP synthase A chain; Region: ATP-synt_A; cl00413 509170000518 ATP synthase subunit C; Region: ATP-synt_C; cl00466 509170000519 Plant ATP synthase F0; Region: YMF19; cl07975 509170000520 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 509170000521 Plant ATP synthase F0; Region: YMF19; cl07975 509170000522 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 509170000523 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 509170000524 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 509170000525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170000526 Walker A motif; other site 509170000527 ATP binding site [chemical binding]; other site 509170000528 Walker B motif; other site 509170000529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509170000530 ATP synthase; Region: ATP-synt; cl00365 509170000531 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 509170000532 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 509170000533 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 509170000534 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 509170000535 alpha subunit interaction interface [polypeptide binding]; other site 509170000536 Walker A motif; other site 509170000537 ATP binding site [chemical binding]; other site 509170000538 Walker B motif; other site 509170000539 inhibitor binding site; inhibition site 509170000540 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509170000541 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 509170000542 Transposase domain (DUF772); Region: DUF772; cl15789 509170000543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000544 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000545 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 509170000546 catalytic residues [active] 509170000547 dimer interface [polypeptide binding]; other site 509170000548 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170000549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170000550 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 509170000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000552 putative substrate translocation pore; other site 509170000553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170000554 Helix-turn-helix domains; Region: HTH; cl00088 509170000555 EamA-like transporter family; Region: EamA; cl01037 509170000556 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170000557 EamA-like transporter family; Region: EamA; cl01037 509170000558 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 509170000559 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 3) 509170000560 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 2) 509170000561 Evidence 7 : Gene remnant; Product type pf : factor; fragment of Rossmann-fold nucleotide-binding protein involved in DNA uptake (Smf) (part 1) 509170000562 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 509170000563 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 509170000564 active site 509170000565 catalytic residues [active] 509170000566 metal binding site [ion binding]; metal-binding site 509170000567 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 509170000568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170000569 N-terminal plug; other site 509170000570 ligand-binding site [chemical binding]; other site 509170000571 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000572 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 509170000573 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcription regulator protein (TetR family) (part 1) 509170000574 Transposase domain (DUF772); Region: DUF772; cl15789 509170000575 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000576 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcription regulator protein (TetR family) (part 2) 509170000577 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 1) 509170000578 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000580 Transposase domain (DUF772); Region: DUF772; cl15789 509170000581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000582 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000584 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 2) 509170000585 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 509170000586 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509170000587 dimer interface [polypeptide binding]; other site 509170000588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000589 catalytic residue [active] 509170000590 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 509170000591 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170000592 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170000593 catalytic residue [active] 509170000594 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000595 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000597 hypothetical protein; Provisional; Region: PRK01254 509170000598 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 509170000599 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 509170000600 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 509170000601 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 509170000602 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 509170000603 homotrimer interaction site [polypeptide binding]; other site 509170000604 putative active site [active] 509170000605 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 509170000606 active site 509170000607 DNA polymerase IV; Validated; Region: PRK02406 509170000608 DNA binding site [nucleotide binding] 509170000609 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of lysozyme (partial) 509170000610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000611 putative transporter; Provisional; Region: PRK10504 509170000612 putative substrate translocation pore; other site 509170000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000614 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 509170000615 Integral membrane protein TerC family; Region: TerC; cl10468 509170000616 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170000617 Transporter associated domain; Region: CorC_HlyC; cl08393 509170000618 hypothetical protein; Provisional; Region: PRK01752 509170000619 SEC-C motif; Region: SEC-C; pfam02810 509170000620 Predicted membrane protein [Function unknown]; Region: COG2860 509170000621 UPF0126 domain; Region: UPF0126; pfam03458 509170000622 UPF0126 domain; Region: UPF0126; pfam03458 509170000623 benzoate transport; Region: 2A0115; TIGR00895 509170000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000625 putative substrate translocation pore; other site 509170000626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000627 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 509170000628 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 509170000629 CAP-like domain; other site 509170000630 active site 509170000631 primary dimer interface [polypeptide binding]; other site 509170000632 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 509170000633 AMP-binding enzyme; Region: AMP-binding; cl15778 509170000634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170000635 MAPEG family; Region: MAPEG; cl09190 509170000636 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 509170000637 dimer interface [polypeptide binding]; other site 509170000638 substrate binding site [chemical binding]; other site 509170000639 metal binding sites [ion binding]; metal-binding site 509170000640 outer membrane porin, OprD family; Region: OprD; pfam03573 509170000641 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000642 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000643 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000644 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 509170000645 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 509170000646 substrate binding site [chemical binding]; other site 509170000647 glutamase interaction surface [polypeptide binding]; other site 509170000648 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 509170000649 Phosphotransferase enzyme family; Region: APH; pfam01636 509170000650 putative active site [active] 509170000651 putative substrate binding site [chemical binding]; other site 509170000652 ATP binding site [chemical binding]; other site 509170000653 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of cold shock protein (part 1) 509170000654 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of cold shock protein (part 2) 509170000655 Predicted membrane protein [Function unknown]; Region: COG3671 509170000656 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (partial) 509170000657 Transposase domain (DUF772); Region: DUF772; cl15789 509170000658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000659 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000661 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (partial) 509170000662 Transposase domain (DUF772); Region: DUF772; cl15789 509170000663 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000664 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 509170000665 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 509170000666 catalytic residues [active] 509170000667 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000668 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000669 Protein of unknown function (DUF805); Region: DUF805; cl01224 509170000670 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 509170000671 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 509170000672 putative active site [active] 509170000673 oxyanion strand; other site 509170000674 catalytic triad [active] 509170000675 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 509170000676 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 509170000677 putative active site pocket [active] 509170000678 4-fold oligomerization interface [polypeptide binding]; other site 509170000679 metal binding residues [ion binding]; metal-binding site 509170000680 3-fold/trimer interface [polypeptide binding]; other site 509170000681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170000682 Coenzyme A binding pocket [chemical binding]; other site 509170000683 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyltransferase (part 2) 509170000684 Transposase domain (DUF772); Region: DUF772; cl15789 509170000685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000686 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyltransferase (part 1) 509170000687 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 509170000688 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 509170000689 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509170000690 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 509170000691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509170000692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170000693 dimer interface [polypeptide binding]; other site 509170000694 phosphorylation site [posttranslational modification] 509170000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170000696 ATP binding site [chemical binding]; other site 509170000697 Mg2+ binding site [ion binding]; other site 509170000698 G-X-G motif; other site 509170000699 osmolarity response regulator; Provisional; Region: ompR; PRK09468 509170000700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170000701 active site 509170000702 phosphorylation site [posttranslational modification] 509170000703 intermolecular recognition site; other site 509170000704 dimerization interface [polypeptide binding]; other site 509170000705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170000706 DNA binding site [nucleotide binding] 509170000707 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 509170000708 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 509170000709 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 509170000710 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 509170000711 RNA binding site [nucleotide binding]; other site 509170000712 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000713 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000714 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000715 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000716 putative transporter; Provisional; Region: PRK11660 509170000717 Sulfate transporter family; Region: Sulfate_transp; cl15842 509170000718 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 509170000719 active site clefts [active] 509170000720 zinc binding site [ion binding]; other site 509170000721 dimer interface [polypeptide binding]; other site 509170000722 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 509170000723 classical (c) SDRs; Region: SDR_c; cd05233 509170000724 NAD(P) binding site [chemical binding]; other site 509170000725 active site 509170000726 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of homocysteine synthase (part 2) 509170000727 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of homocysteine synthase (part 1) 509170000728 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 509170000729 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000730 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000731 ABC transporter; Region: ABC_tran_2; pfam12848 509170000732 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170000733 Sel1 repeat; Region: Sel1; cl02723 509170000734 hypothetical protein; Provisional; Region: PRK10215 509170000735 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509170000736 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170000737 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 509170000738 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170000739 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 509170000740 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000741 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000742 Cation efflux family; Region: Cation_efflux; cl00316 509170000743 Transposase domain (DUF772); Region: DUF772; cl15789 509170000744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000745 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000746 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000747 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170000748 S-methylmethionine transporter; Provisional; Region: PRK11387 509170000749 Spore germination protein; Region: Spore_permease; cl15802 509170000750 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 509170000751 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509170000752 active site 509170000753 HIGH motif; other site 509170000754 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509170000755 active site 509170000756 KMSKS motif; other site 509170000757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170000758 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509170000759 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 509170000760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000761 Septum formation initiator; Region: DivIC; cl11433 509170000762 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 509170000763 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509170000764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170000765 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 509170000766 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170000767 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170000768 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170000769 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 509170000770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170000771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170000772 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 509170000773 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 509170000774 Mg++ binding site [ion binding]; other site 509170000775 putative catalytic motif [active] 509170000776 putative substrate binding site [chemical binding]; other site 509170000777 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000778 Transposase domain (DUF772); Region: DUF772; cl15789 509170000779 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000780 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000781 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 509170000782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170000783 S-adenosylmethionine binding site [chemical binding]; other site 509170000784 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 509170000785 Transglycosylase; Region: Transgly; cl07896 509170000786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170000787 Competence protein A; Region: Competence_A; pfam11104 509170000788 Cell division protein FtsA; Region: FtsA; cl11496 509170000789 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (ComN) (part 1) 509170000790 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein (ComN) (part 2) 509170000791 Pilus assembly protein, PilO; Region: PilO; cl01234 509170000792 Pilus assembly protein, PilP; Region: PilP; cl01235 509170000793 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 1) 509170000794 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 2) 509170000795 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of outer membrane protein (ComQ) (part 3) 509170000796 shikimate kinase; Reviewed; Region: aroK; PRK00131 509170000797 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 509170000798 ADP binding site [chemical binding]; other site 509170000799 magnesium binding site [ion binding]; other site 509170000800 putative shikimate binding site; other site 509170000801 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 509170000802 active site 509170000803 dimer interface [polypeptide binding]; other site 509170000804 metal binding site [ion binding]; metal-binding site 509170000805 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 509170000806 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 509170000807 active site 509170000808 dimer interface [polypeptide binding]; other site 509170000809 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 509170000810 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 509170000811 active site 509170000812 FMN binding site [chemical binding]; other site 509170000813 substrate binding site [chemical binding]; other site 509170000814 3Fe-4S cluster binding site [ion binding]; other site 509170000815 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 509170000816 domain interface; other site 509170000817 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 509170000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170000820 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170000821 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170000822 LemA family; Region: LemA; cl00742 509170000823 Repair protein; Region: Repair_PSII; cl01535 509170000824 Repair protein; Region: Repair_PSII; cl01535 509170000825 Transposase domain (DUF772); Region: DUF772; cl15789 509170000826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000827 Evidence 7 : Gene remnant; Product type ps : structure; fragment of fimbrial protein precursor (Pilin) (partial) 509170000828 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170000829 O-Antigen ligase; Region: Wzy_C; cl04850 509170000830 O-Antigen ligase; Region: Wzy_C; cl04850 509170000831 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 509170000832 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 509170000833 heme binding site [chemical binding]; other site 509170000834 Ferritin-like domain; Region: Ferritin; pfam00210 509170000835 ferroxidase pore; other site 509170000836 ferroxidase diiron center [ion binding]; other site 509170000837 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 509170000838 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509170000839 homotrimer interaction site [polypeptide binding]; other site 509170000840 putative active site [active] 509170000841 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509170000842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170000843 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509170000844 synthetase active site [active] 509170000845 NTP binding site [chemical binding]; other site 509170000846 metal binding site [ion binding]; metal-binding site 509170000847 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 509170000848 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170000849 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 509170000850 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 509170000851 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 509170000852 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 509170000853 catalytic site [active] 509170000854 G-X2-G-X-G-K; other site 509170000855 LytB protein; Region: LYTB; cl00507 509170000856 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 509170000857 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000858 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000859 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 509170000860 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 509170000861 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 509170000862 RimM N-terminal domain; Region: RimM; pfam01782 509170000863 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 509170000864 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 509170000865 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 509170000866 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of lipase (part 2) 509170000867 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of lipase (part 1) 509170000868 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 509170000869 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 509170000870 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 509170000871 RNA binding site [nucleotide binding]; other site 509170000872 active site 509170000873 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509170000874 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170000875 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 509170000876 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 509170000877 threonine and homoserine efflux system; Provisional; Region: PRK10532 509170000878 EamA-like transporter family; Region: EamA; cl01037 509170000879 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 509170000880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170000881 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 509170000882 L-serine binding site [chemical binding]; other site 509170000883 ACT domain interface; other site 509170000884 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 509170000885 FAD binding domain; Region: FAD_binding_4; pfam01565 509170000886 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170000887 Transposase domain (DUF772); Region: DUF772; cl15789 509170000888 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000889 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 509170000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170000891 putative substrate translocation pore; other site 509170000892 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 509170000893 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 509170000894 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 509170000895 E-class dimer interface [polypeptide binding]; other site 509170000896 P-class dimer interface [polypeptide binding]; other site 509170000897 active site 509170000898 Cu2+ binding site [ion binding]; other site 509170000899 Zn2+ binding site [ion binding]; other site 509170000900 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 509170000901 Domain of unknown function DUF20; Region: UPF0118; pfam01594 509170000902 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170000903 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170000904 P-loop; other site 509170000905 Magnesium ion binding site [ion binding]; other site 509170000906 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 509170000907 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000908 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170000909 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000910 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000911 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 509170000912 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509170000913 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 509170000914 NAD(P) binding site [chemical binding]; other site 509170000915 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 509170000916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170000917 inhibitor-cofactor binding pocket; inhibition site 509170000918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170000919 catalytic residue [active] 509170000920 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 509170000921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170000922 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 509170000923 NAD(P) binding site [chemical binding]; other site 509170000924 catalytic residues [active] 509170000925 Succinylarginine dihydrolase; Region: AstB; cl01511 509170000926 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 509170000927 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 509170000928 putative active site [active] 509170000929 Zn binding site [ion binding]; other site 509170000930 Transposase domain (DUF772); Region: DUF772; cl15789 509170000931 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000932 Evidence 4 : Homologs of previously reported genes of unknown function; fragment of conserved hypothetical protein; exported protein (partial) 509170000933 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 509170000934 active site 509170000935 catalytic residues [active] 509170000936 Transposase domain (DUF772); Region: DUF772; cl15789 509170000937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170000939 Helix-turn-helix domains; Region: HTH; cl00088 509170000940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170000941 dimerization interface [polypeptide binding]; other site 509170000942 EamA-like transporter family; Region: EamA; cl01037 509170000943 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170000944 EamA-like transporter family; Region: EamA; cl01037 509170000945 YCII-related domain; Region: YCII; cl00999 509170000946 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 509170000947 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 509170000948 dimer interface [polypeptide binding]; other site 509170000949 motif 1; other site 509170000950 active site 509170000951 motif 2; other site 509170000952 motif 3; other site 509170000953 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Tetracycline resistance protein, class A (TETA(A)) (part 1) 509170000954 Transposase domain (DUF772); Region: DUF772; cl15789 509170000955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000956 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Tetracycline resistance protein, class A (TETA(A)) (part 2) 509170000957 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 509170000958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170000959 FeS/SAM binding site; other site 509170000960 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 509170000961 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000963 PspC domain; Region: PspC; cl00864 509170000964 hypothetical protein; Provisional; Region: PRK11615 509170000965 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170000966 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170000967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170000968 active site 509170000969 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170000970 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170000971 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170000972 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 1) 509170000973 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170000974 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 509170000975 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 509170000976 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 509170000977 shikimate binding site; other site 509170000978 NAD(P) binding site [chemical binding]; other site 509170000979 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 509170000980 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 509170000981 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 509170000982 dimerization interface [polypeptide binding]; other site 509170000983 active site 509170000984 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 509170000985 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 509170000986 TPP-binding site; other site 509170000987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509170000988 PYR/PP interface [polypeptide binding]; other site 509170000989 dimer interface [polypeptide binding]; other site 509170000990 TPP binding site [chemical binding]; other site 509170000991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509170000992 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 509170000993 active site 509170000994 dimerization interface [polypeptide binding]; other site 509170000995 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 509170000996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509170000997 ATP binding site [chemical binding]; other site 509170000998 Mg++ binding site [ion binding]; other site 509170000999 motif III; other site 509170001000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170001001 nucleotide binding region [chemical binding]; other site 509170001002 ATP-binding site [chemical binding]; other site 509170001003 transcription termination factor Rho; Provisional; Region: PRK12678 509170001004 Transposase domain (DUF772); Region: DUF772; cl15789 509170001005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001006 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 509170001007 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 509170001008 Walker A/P-loop; other site 509170001009 ATP binding site [chemical binding]; other site 509170001010 Q-loop/lid; other site 509170001011 ABC transporter signature motif; other site 509170001012 Walker B; other site 509170001013 D-loop; other site 509170001014 H-loop/switch region; other site 509170001015 Permease; Region: Permease; cl00510 509170001016 mce related protein; Region: MCE; pfam02470 509170001017 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 509170001018 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 509170001019 anti sigma factor interaction site; other site 509170001020 regulatory phosphorylation site [posttranslational modification]; other site 509170001021 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 509170001022 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 509170001023 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 509170001024 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 509170001025 nudix motif; other site 509170001026 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 509170001027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170001028 active site 509170001029 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 509170001030 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 509170001031 ssDNA binding site; other site 509170001032 generic binding surface II; other site 509170001033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170001034 ATP binding site [chemical binding]; other site 509170001035 putative Mg++ binding site [ion binding]; other site 509170001036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170001037 nucleotide binding region [chemical binding]; other site 509170001038 ATP-binding site [chemical binding]; other site 509170001039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001040 NADH(P)-binding; Region: NAD_binding_10; pfam13460 509170001041 NAD(P) binding site [chemical binding]; other site 509170001042 active site 509170001043 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 509170001044 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 509170001045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 509170001046 putative acyl-acceptor binding pocket; other site 509170001047 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 509170001048 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 509170001049 active site 509170001050 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 509170001051 catalytic triad [active] 509170001052 dimer interface [polypeptide binding]; other site 509170001053 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 1) 509170001054 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 2) 509170001055 Transposase domain (DUF772); Region: DUF772; cl15789 509170001056 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001057 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Proton/sodium-glutamate symport protein (part 3) 509170001058 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170001059 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170001060 Predicted GTPase [General function prediction only]; Region: COG0218 509170001061 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 509170001062 G1 box; other site 509170001063 GTP/Mg2+ binding site [chemical binding]; other site 509170001064 Switch I region; other site 509170001065 G2 box; other site 509170001066 G3 box; other site 509170001067 Switch II region; other site 509170001068 G4 box; other site 509170001069 G5 box; other site 509170001070 Predicted transcriptional regulator [Transcription]; Region: COG1959 509170001071 Helix-turn-helix domains; Region: HTH; cl00088 509170001072 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 509170001073 heme-binding site [chemical binding]; other site 509170001074 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 509170001075 FAD binding pocket [chemical binding]; other site 509170001076 conserved FAD binding motif [chemical binding]; other site 509170001077 phosphate binding motif [ion binding]; other site 509170001078 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 3) 509170001079 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 2) 509170001080 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of enzyme contains P-loop containing nucleotide triphosphate hydrolase domain (part 1) 509170001081 cystathionine beta-lyase; Provisional; Region: PRK07050 509170001082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170001083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170001084 catalytic residue [active] 509170001085 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509170001086 catalytic triad [active] 509170001087 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 509170001088 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 509170001089 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 509170001090 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 509170001091 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 509170001092 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 509170001093 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 509170001094 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 509170001095 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 509170001096 putative translocon binding site; other site 509170001097 protein-rRNA interface [nucleotide binding]; other site 509170001098 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 509170001099 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 509170001100 G-X-X-G motif; other site 509170001101 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 509170001102 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 509170001103 23S rRNA interface [nucleotide binding]; other site 509170001104 5S rRNA interface [nucleotide binding]; other site 509170001105 putative antibiotic binding site [chemical binding]; other site 509170001106 L25 interface [polypeptide binding]; other site 509170001107 L27 interface [polypeptide binding]; other site 509170001108 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 509170001109 23S rRNA interface [nucleotide binding]; other site 509170001110 putative translocon interaction site; other site 509170001111 signal recognition particle (SRP54) interaction site; other site 509170001112 L23 interface [polypeptide binding]; other site 509170001113 trigger factor interaction site; other site 509170001114 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 509170001115 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 509170001116 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 509170001117 KOW motif; Region: KOW; cl00354 509170001118 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 509170001119 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 509170001120 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 509170001121 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 509170001122 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 509170001123 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 509170001124 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509170001125 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509170001126 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 509170001127 5S rRNA interface [nucleotide binding]; other site 509170001128 23S rRNA interface [nucleotide binding]; other site 509170001129 L5 interface [polypeptide binding]; other site 509170001130 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 509170001131 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 509170001132 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 509170001133 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 509170001134 23S rRNA binding site [nucleotide binding]; other site 509170001135 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 509170001136 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 509170001137 SecY translocase; Region: SecY; pfam00344 509170001138 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 509170001139 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 509170001140 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 509170001141 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 509170001142 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 509170001143 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 509170001144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170001145 RNA binding surface [nucleotide binding]; other site 509170001146 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 509170001147 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 509170001148 alphaNTD homodimer interface [polypeptide binding]; other site 509170001149 alphaNTD - beta interaction site [polypeptide binding]; other site 509170001150 alphaNTD - beta' interaction site [polypeptide binding]; other site 509170001151 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 509170001152 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 509170001153 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509170001154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001155 NAD(P) binding pocket [chemical binding]; other site 509170001156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170001157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001158 active site 509170001159 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 509170001160 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001161 Rhomboid family; Region: Rhomboid; cl11446 509170001162 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 509170001163 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 509170001164 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001165 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 509170001166 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 509170001167 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 509170001168 active site 509170001169 Zn binding site [ion binding]; other site 509170001170 ribonuclease R; Region: RNase_R; TIGR02063 509170001171 RNB domain; Region: RNB; pfam00773 509170001172 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 509170001173 RNA binding site [nucleotide binding]; other site 509170001174 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001175 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001176 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001177 YcxB-like protein; Region: YcxB; pfam14317 509170001178 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509170001179 Cupin domain; Region: Cupin_2; cl09118 509170001180 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170001181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001182 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 509170001183 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170001184 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 509170001185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170001186 active site 509170001187 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 509170001188 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 509170001189 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170001190 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001191 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001192 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 509170001193 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 509170001194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170001195 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 509170001196 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509170001197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170001198 FeS/SAM binding site; other site 509170001199 TRAM domain; Region: TRAM; cl01282 509170001200 lytic murein transglycosylase; Provisional; Region: PRK11619 509170001201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170001202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170001203 catalytic residue [active] 509170001204 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 509170001205 B1 nucleotide binding pocket [chemical binding]; other site 509170001206 B2 nucleotide binding pocket [chemical binding]; other site 509170001207 CAS motifs; other site 509170001208 active site 509170001209 malate dehydrogenase; Provisional; Region: PRK05442 509170001210 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 509170001211 NAD(P) binding site [chemical binding]; other site 509170001212 dimer interface [polypeptide binding]; other site 509170001213 malate binding site [chemical binding]; other site 509170001214 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 509170001215 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 509170001216 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 509170001217 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 509170001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170001219 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 509170001220 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509170001221 Transposase domain (DUF772); Region: DUF772; cl15789 509170001222 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001223 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 509170001224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170001225 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170001226 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001227 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001229 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170001230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170001231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170001232 Evidence 7 : Gene remnant; Product type c : carrier; fragment of thioredoxin C-3 (part 1) 509170001233 Evidence 7 : Gene remnant; Product type c : carrier; fragment of thioredoxin C-3 (part 2) 509170001234 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 509170001235 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170001236 CoenzymeA binding site [chemical binding]; other site 509170001237 subunit interaction site [polypeptide binding]; other site 509170001238 PHB binding site; other site 509170001239 Protein of unknown function (DUF520); Region: DUF520; cl00723 509170001240 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 509170001241 active site residue [active] 509170001242 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 509170001243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170001244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001245 YCII-related domain; Region: YCII; cl00999 509170001246 Intracellular septation protein A; Region: IspA; cl01098 509170001247 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 509170001248 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001249 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA repair protein, associated with replication forks (RadC) (part 2) 509170001250 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA repair protein, associated with replication forks (RadC) (part 1) 509170001251 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 509170001252 Flavoprotein; Region: Flavoprotein; cl08021 509170001253 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 509170001254 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 509170001255 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509170001256 Protein export membrane protein; Region: SecD_SecF; cl14618 509170001257 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 509170001258 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 509170001259 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509170001260 Protein export membrane protein; Region: SecD_SecF; cl14618 509170001261 Preprotein translocase subunit; Region: YajC; cl00806 509170001262 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 509170001263 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 509170001264 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001266 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 509170001267 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 509170001268 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of sensory transduction histidine kinase (part 1) 509170001269 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of sensory transduction histidine kinase (part 2) 509170001270 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 509170001271 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170001272 metal binding triad; other site 509170001273 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509170001274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170001275 metal binding triad; other site 509170001276 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 509170001277 homodimer interface [polypeptide binding]; other site 509170001278 substrate-cofactor binding pocket; other site 509170001279 catalytic residue [active] 509170001280 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 509170001281 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 509170001282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170001283 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 509170001284 putative active site [active] 509170001285 putative metal binding site [ion binding]; other site 509170001286 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 509170001287 putative metal binding site; other site 509170001288 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 509170001289 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 509170001290 putative ADP-binding pocket [chemical binding]; other site 509170001291 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 509170001292 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001293 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001294 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycosyl transferase (partial) 509170001295 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 509170001296 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 509170001297 dimer interface [polypeptide binding]; other site 509170001298 anticodon binding site; other site 509170001299 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 509170001300 homodimer interface [polypeptide binding]; other site 509170001301 motif 1; other site 509170001302 active site 509170001303 motif 2; other site 509170001304 GAD domain; Region: GAD; pfam02938 509170001305 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 509170001306 active site 509170001307 motif 3; other site 509170001308 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 509170001309 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 509170001310 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170001311 N-terminal plug; other site 509170001312 ligand-binding site [chemical binding]; other site 509170001313 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 509170001314 putative active site [active] 509170001315 putative catalytic site [active] 509170001316 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 509170001317 PLD-like domain; Region: PLDc_2; pfam13091 509170001318 putative active site [active] 509170001319 putative catalytic site [active] 509170001320 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 509170001321 Phosphate-starvation-inducible E; Region: PsiE; cl01264 509170001322 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509170001323 C-terminal domain interface [polypeptide binding]; other site 509170001324 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509170001325 GSH binding site (G-site) [chemical binding]; other site 509170001326 dimer interface [polypeptide binding]; other site 509170001327 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509170001328 N-terminal domain interface [polypeptide binding]; other site 509170001329 dimer interface [polypeptide binding]; other site 509170001330 substrate binding pocket (H-site) [chemical binding]; other site 509170001331 LysR family transcriptional regulator; Provisional; Region: PRK14997 509170001332 Helix-turn-helix domains; Region: HTH; cl00088 509170001333 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509170001334 putative effector binding pocket; other site 509170001335 dimerization interface [polypeptide binding]; other site 509170001336 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170001337 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170001338 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001339 active site 509170001340 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170001341 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 509170001342 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 509170001343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170001344 active site 509170001345 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 509170001346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 509170001347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170001348 dimer interface [polypeptide binding]; other site 509170001349 phosphorylation site [posttranslational modification] 509170001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170001351 ATP binding site [chemical binding]; other site 509170001352 Mg2+ binding site [ion binding]; other site 509170001353 G-X-G motif; other site 509170001354 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 509170001355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001356 active site 509170001357 phosphorylation site [posttranslational modification] 509170001358 intermolecular recognition site; other site 509170001359 dimerization interface [polypeptide binding]; other site 509170001360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170001361 DNA binding site [nucleotide binding] 509170001362 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 509170001363 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 509170001364 Di-iron ligands [ion binding]; other site 509170001365 META domain; Region: META; cl01245 509170001366 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycerophosphodiester phosphodiesterase (part 2) 509170001367 Transposase domain (DUF772); Region: DUF772; cl15789 509170001368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001369 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glycerophosphodiester phosphodiesterase (part 1) 509170001370 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 509170001371 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 3) 509170001372 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 2) 509170001373 Evidence 7 : Gene remnant; Product type t : transporter; fragment of TonB-dependent Outer membrane receptor for vitamin B12/cobalamin transport (Btub) (part 1) 509170001374 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 509170001375 active site 509170001376 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509170001377 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 509170001378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170001379 catalytic residue [active] 509170001380 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001381 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001382 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 509170001383 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170001384 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170001385 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170001386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001387 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 509170001388 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 509170001389 substrate binding site [chemical binding]; other site 509170001390 active site 509170001391 catalytic residues [active] 509170001392 heterodimer interface [polypeptide binding]; other site 509170001393 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 509170001394 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 509170001395 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 509170001396 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170001397 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170001398 Sporulation related domain; Region: SPOR; cl10051 509170001399 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170001400 active site 509170001401 catalytic residues [active] 509170001402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170001403 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of antioxidant protein (part 2) 509170001404 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of antioxidant protein (part 1) 509170001405 Transposase domain (DUF772); Region: DUF772; cl15789 509170001406 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001407 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 509170001408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170001409 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 509170001410 SEC-C motif; Region: SEC-C; pfam02810 509170001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170001412 metabolite-proton symporter; Region: 2A0106; TIGR00883 509170001413 putative substrate translocation pore; other site 509170001414 Haemolysin-III related; Region: HlyIII; cl03831 509170001415 Methyltransferase domain; Region: Methyltransf_31; pfam13847 509170001416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001417 S-adenosylmethionine binding site [chemical binding]; other site 509170001418 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170001419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170001420 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 509170001421 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 509170001422 active site 509170001423 nucleophile elbow; other site 509170001424 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 509170001425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170001426 substrate binding site [chemical binding]; other site 509170001427 oxyanion hole (OAH) forming residues; other site 509170001428 trimer interface [polypeptide binding]; other site 509170001429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001430 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170001431 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 509170001432 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170001433 dimer interface [polypeptide binding]; other site 509170001434 active site 509170001435 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170001436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001438 Transposase domain (DUF772); Region: DUF772; cl15789 509170001439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001440 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509170001441 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509170001442 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 509170001443 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 509170001444 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 509170001445 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 509170001446 Trp docking motif [polypeptide binding]; other site 509170001447 putative active site [active] 509170001448 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 509170001449 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509170001450 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509170001451 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 509170001452 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 509170001453 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001454 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001455 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001456 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 509170001457 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170001458 dimer interface [polypeptide binding]; other site 509170001459 active site 509170001460 Transposase domain (DUF772); Region: DUF772; cl15789 509170001461 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001462 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 509170001463 Type II transport protein GspH; Region: GspH; pfam12019 509170001464 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 509170001465 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170001466 ligand binding site [chemical binding]; other site 509170001467 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001468 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001469 lysine transporter; Provisional; Region: PRK10836 509170001470 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 509170001471 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 509170001472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001473 S-adenosylmethionine binding site [chemical binding]; other site 509170001474 xanthine permease; Region: pbuX; TIGR03173 509170001475 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 509170001476 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 509170001477 G1 box; other site 509170001478 putative GEF interaction site [polypeptide binding]; other site 509170001479 GTP/Mg2+ binding site [chemical binding]; other site 509170001480 Switch I region; other site 509170001481 G2 box; other site 509170001482 G3 box; other site 509170001483 Switch II region; other site 509170001484 G4 box; other site 509170001485 G5 box; other site 509170001486 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 509170001487 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 509170001488 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 509170001489 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 509170001490 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 509170001491 putative active site pocket [active] 509170001492 dimerization interface [polypeptide binding]; other site 509170001493 putative catalytic residue [active] 509170001494 PPIC-type PPIASE domain; Region: Rotamase; cl08278 509170001495 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 509170001496 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 509170001497 DNA binding site [nucleotide binding] 509170001498 catalytic residue [active] 509170001499 H2TH interface [polypeptide binding]; other site 509170001500 putative catalytic residues [active] 509170001501 turnover-facilitating residue; other site 509170001502 intercalation triad [nucleotide binding]; other site 509170001503 8OG recognition residue [nucleotide binding]; other site 509170001504 putative reading head residues; other site 509170001505 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 509170001506 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509170001507 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 509170001508 active site 509170001509 DNA binding site [nucleotide binding] 509170001510 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509170001511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170001512 N-terminal plug; other site 509170001513 ligand-binding site [chemical binding]; other site 509170001514 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of FMN oxidoreductase (part 1) 509170001515 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of FMN oxidoreductase (part 2) 509170001516 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 1) 509170001517 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 2) 509170001518 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 509170001519 Sel1 repeat; Region: Sel1; cl02723 509170001520 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 509170001521 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170001522 dimerization domain [polypeptide binding]; other site 509170001523 dimer interface [polypeptide binding]; other site 509170001524 catalytic residues [active] 509170001525 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001526 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001527 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 509170001528 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 509170001529 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 509170001530 putative hydrophobic ligand binding site [chemical binding]; other site 509170001531 Protein of unknown function, DUF488; Region: DUF488; cl01246 509170001532 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 509170001533 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 509170001534 PhnA protein; Region: PhnA; pfam03831 509170001535 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 509170001536 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 509170001537 prolyl-tRNA synthetase; Provisional; Region: PRK09194 509170001538 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 509170001539 dimer interface [polypeptide binding]; other site 509170001540 motif 1; other site 509170001541 active site 509170001542 motif 2; other site 509170001543 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 509170001544 putative deacylase active site [active] 509170001545 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 509170001546 active site 509170001547 motif 3; other site 509170001548 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 509170001549 anticodon binding site; other site 509170001550 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509170001551 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170001552 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170001553 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001554 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001555 Response regulator receiver domain; Region: Response_reg; pfam00072 509170001556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001557 active site 509170001558 phosphorylation site [posttranslational modification] 509170001559 intermolecular recognition site; other site 509170001560 dimerization interface [polypeptide binding]; other site 509170001561 Response regulator receiver domain; Region: Response_reg; pfam00072 509170001562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170001563 active site 509170001564 phosphorylation site [posttranslational modification] 509170001565 intermolecular recognition site; other site 509170001566 dimerization interface [polypeptide binding]; other site 509170001567 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 509170001568 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 509170001569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509170001570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 509170001571 dimer interface [polypeptide binding]; other site 509170001572 putative CheW interface [polypeptide binding]; other site 509170001573 Evidence 7 : Gene remnant; Product type r : regulator; fragment of component of chemotactic signal transduction system (part 1) 509170001574 Evidence 7 : Gene remnant; Product type r : regulator; fragment of component of chemotactic signal transduction system (part 2) 509170001575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 509170001576 active site 509170001577 dimerization interface [polypeptide binding]; other site 509170001578 Transposase domain (DUF772); Region: DUF772; cl15789 509170001579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001580 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 509170001581 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 509170001582 metal binding site [ion binding]; metal-binding site 509170001583 dimer interface [polypeptide binding]; other site 509170001584 Entericidin EcnA/B family; Region: Entericidin; cl02322 509170001585 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001586 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001587 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001588 Protein of unknown function (DUF454); Region: DUF454; cl01063 509170001589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 509170001590 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 509170001591 Transposase domain (DUF772); Region: DUF772; cl15789 509170001592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001593 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 509170001594 putative active site [active] 509170001595 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 509170001596 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 509170001597 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 509170001598 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 509170001599 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170001600 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 509170001601 FAD binding pocket [chemical binding]; other site 509170001602 FAD binding motif [chemical binding]; other site 509170001603 catalytic residues [active] 509170001604 NAD binding pocket [chemical binding]; other site 509170001605 phosphate binding motif [ion binding]; other site 509170001606 beta-alpha-beta structure motif; other site 509170001607 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170001608 YcxB-like protein; Region: YcxB; pfam14317 509170001609 hypothetical membrane protein, TIGR01666; Region: YCCS 509170001610 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 509170001611 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 509170001612 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 509170001613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170001614 putative substrate translocation pore; other site 509170001615 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of nitroreductase (part 2) 509170001616 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of nitroreductase (part 1) 509170001617 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001619 Transposase domain (DUF772); Region: DUF772; cl15789 509170001620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001621 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino-acid transport protein (part 1) 509170001622 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino-acid transport protein (part 2) 509170001623 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 509170001624 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509170001625 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 509170001626 active site 509170001627 nucleophile elbow; other site 509170001628 threonine dehydratase; Provisional; Region: PRK07334 509170001629 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509170001630 tetramer interface [polypeptide binding]; other site 509170001631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170001632 catalytic residue [active] 509170001633 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 509170001634 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509170001635 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 509170001636 intracellular protease, PfpI family; Region: PfpI; TIGR01382 509170001637 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 509170001638 conserved cys residue [active] 509170001639 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 509170001640 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 509170001641 GatB domain; Region: GatB_Yqey; cl11497 509170001642 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 509170001643 Amidase; Region: Amidase; cl11426 509170001644 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 509170001645 rod shape-determining protein MreB; Provisional; Region: PRK13927 509170001646 Cell division protein FtsA; Region: FtsA; cl11496 509170001647 rod shape-determining protein MreC; Provisional; Region: PRK13922 509170001648 rod shape-determining protein MreC; Region: MreC; pfam04085 509170001649 rod shape-determining protein MreD; Region: MreD; cl01087 509170001650 Maf-like protein; Region: Maf; pfam02545 509170001651 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509170001652 active site 509170001653 dimer interface [polypeptide binding]; other site 509170001654 ribonuclease G; Provisional; Region: PRK11712 509170001655 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 509170001656 homodimer interface [polypeptide binding]; other site 509170001657 oligonucleotide binding site [chemical binding]; other site 509170001658 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 509170001659 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 509170001660 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509170001661 Active Sites [active] 509170001662 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170001663 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509170001664 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 509170001665 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170001666 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (part 1) 509170001667 Transposase domain (DUF772); Region: DUF772; cl15789 509170001668 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001669 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (part 2) 509170001670 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 509170001671 putative di-iron ligands [ion binding]; other site 509170001672 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 509170001673 Mrr N-terminal domain; Region: Mrr_N; pfam14338 509170001674 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 509170001675 Bacitracin resistance protein BacA; Region: BacA; cl00858 509170001676 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 509170001677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170001679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170001680 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 509170001681 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 509170001682 NAD(P) binding site [chemical binding]; other site 509170001683 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001684 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001685 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 509170001686 catalytic site [active] 509170001687 Asp-box motif; other site 509170001688 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 509170001689 catalytic residues [active] 509170001690 PAAR motif; Region: PAAR_motif; cl15808 509170001691 integrase; Provisional; Region: PRK09692 509170001692 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170001693 active site 509170001694 Int/Topo IB signature motif; other site 509170001695 aromatic amino acid transporter; Provisional; Region: PRK10238 509170001696 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 509170001697 PrpF protein; Region: PrpF; pfam04303 509170001698 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509170001699 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509170001700 substrate binding pocket [chemical binding]; other site 509170001701 chain length determination region; other site 509170001702 substrate-Mg2+ binding site; other site 509170001703 catalytic residues [active] 509170001704 aspartate-rich region 1; other site 509170001705 active site lid residues [active] 509170001706 aspartate-rich region 2; other site 509170001707 Protein of unknown function (DUF419); Region: DUF419; cl15265 509170001708 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 509170001709 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 509170001710 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 509170001711 hypothetical protein; Provisional; Region: PRK10279 509170001712 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 509170001713 nucleophile elbow; other site 509170001714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 509170001715 putative acyl-acceptor binding pocket; other site 509170001716 muropeptide transporter; Validated; Region: ampG; PRK11010 509170001717 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001718 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001719 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001720 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001721 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 509170001722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001723 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 509170001724 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509170001725 HIGH motif; other site 509170001726 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170001727 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509170001728 active site 509170001729 KMSKS motif; other site 509170001730 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 509170001731 tRNA binding surface [nucleotide binding]; other site 509170001732 anticodon binding site; other site 509170001733 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 509170001734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001735 short chain dehydrogenase; Provisional; Region: PRK06181 509170001736 NAD(P) binding site [chemical binding]; other site 509170001737 active site 509170001738 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001739 Transposase domain (DUF772); Region: DUF772; cl15789 509170001740 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001741 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 509170001742 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 509170001743 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509170001744 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 509170001745 Protein export membrane protein; Region: SecD_SecF; cl14618 509170001746 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 509170001747 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170001748 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170001749 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 509170001750 active site 509170001751 Site-specific recombinase; Region: SpecificRecomb; cl15411 509170001752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509170001753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509170001754 substrate binding pocket [chemical binding]; other site 509170001755 chain length determination region; other site 509170001756 substrate-Mg2+ binding site; other site 509170001757 catalytic residues [active] 509170001758 aspartate-rich region 1; other site 509170001759 active site lid residues [active] 509170001760 aspartate-rich region 2; other site 509170001761 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 509170001762 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 509170001763 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 509170001764 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 509170001765 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170001766 seryl-tRNA synthetase; Provisional; Region: PRK05431 509170001767 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 509170001768 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 509170001769 dimer interface [polypeptide binding]; other site 509170001770 active site 509170001771 motif 1; other site 509170001772 motif 2; other site 509170001773 motif 3; other site 509170001774 siroheme synthase; Provisional; Region: cysG; PRK10637 509170001775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001776 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 509170001777 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 509170001778 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509170001779 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001780 Transposase domain (DUF772); Region: DUF772; cl15789 509170001781 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001782 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001783 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001784 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001785 amino acid transporter; Region: 2A0306; TIGR00909 509170001786 Spore germination protein; Region: Spore_permease; cl15802 509170001787 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 509170001788 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 509170001789 putative active site [active] 509170001790 metal binding site [ion binding]; metal-binding site 509170001791 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509170001792 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001794 Protein of unknown function (DUF493); Region: DUF493; cl01102 509170001795 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 509170001796 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509170001797 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 509170001798 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 509170001799 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 509170001800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170001801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509170001802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170001803 DNA binding residues [nucleotide binding] 509170001804 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 509170001805 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001806 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001807 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 509170001808 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 509170001809 active site residue [active] 509170001810 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 509170001811 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 509170001812 dimer interface [polypeptide binding]; other site 509170001813 Citrate synthase; Region: Citrate_synt; pfam00285 509170001814 active site 509170001815 citrylCoA binding site [chemical binding]; other site 509170001816 NADH binding [chemical binding]; other site 509170001817 cationic pore residues; other site 509170001818 oxalacetate/citrate binding site [chemical binding]; other site 509170001819 coenzyme A binding site [chemical binding]; other site 509170001820 catalytic triad [active] 509170001821 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 509170001822 Iron-sulfur protein interface; other site 509170001823 proximal quinone binding site [chemical binding]; other site 509170001824 SdhD (CybS) interface [polypeptide binding]; other site 509170001825 proximal heme binding site [chemical binding]; other site 509170001826 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 509170001827 SdhC subunit interface [polypeptide binding]; other site 509170001828 proximal heme binding site [chemical binding]; other site 509170001829 cardiolipin binding site; other site 509170001830 Iron-sulfur protein interface; other site 509170001831 proximal quinone binding site [chemical binding]; other site 509170001832 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 509170001833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001834 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509170001835 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 509170001836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 509170001837 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 509170001838 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 509170001839 TPP-binding site [chemical binding]; other site 509170001840 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 509170001841 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 509170001842 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170001843 E3 interaction surface; other site 509170001844 lipoyl attachment site [posttranslational modification]; other site 509170001845 e3 binding domain; Region: E3_binding; pfam02817 509170001846 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 509170001847 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 509170001848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170001850 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170001851 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 509170001852 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170001853 CoA-ligase; Region: Ligase_CoA; cl02894 509170001854 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 509170001855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001856 CoA-ligase; Region: Ligase_CoA; cl02894 509170001857 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001858 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001859 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 509170001860 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 509170001861 active site 509170001862 HIGH motif; other site 509170001863 dimer interface [polypeptide binding]; other site 509170001864 KMSKS motif; other site 509170001865 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001866 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001867 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001868 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 509170001869 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 509170001870 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 509170001871 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 509170001872 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 509170001873 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 509170001874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170001875 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170001876 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 509170001877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170001878 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170001879 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 509170001880 IMP binding site; other site 509170001881 dimer interface [polypeptide binding]; other site 509170001882 interdomain contacts; other site 509170001883 partial ornithine binding site; other site 509170001884 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 509170001885 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 509170001886 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 509170001887 catalytic site [active] 509170001888 subunit interface [polypeptide binding]; other site 509170001889 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001890 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 509170001891 putative heme binding site [chemical binding]; other site 509170001892 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 509170001893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170001894 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 509170001895 FtsH Extracellular; Region: FtsH_ext; pfam06480 509170001896 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 509170001897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170001898 Walker A motif; other site 509170001899 ATP binding site [chemical binding]; other site 509170001900 Walker B motif; other site 509170001901 arginine finger; other site 509170001902 Peptidase family M41; Region: Peptidase_M41; pfam01434 509170001903 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 509170001904 dihydropteroate synthase; Region: DHPS; TIGR01496 509170001905 substrate binding pocket [chemical binding]; other site 509170001906 dimer interface [polypeptide binding]; other site 509170001907 inhibitor binding site; inhibition site 509170001908 PhoD-like phosphatase; Region: PhoD; pfam09423 509170001909 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509170001910 putative active site [active] 509170001911 putative metal binding site [ion binding]; other site 509170001912 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 509170001913 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 509170001914 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 509170001915 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 509170001916 homodimer interface [polypeptide binding]; other site 509170001917 NADP binding site [chemical binding]; other site 509170001918 substrate binding site [chemical binding]; other site 509170001919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170001920 S-adenosylmethionine binding site [chemical binding]; other site 509170001921 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 509170001922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170001923 putative substrate translocation pore; other site 509170001924 glycerol kinase; Provisional; Region: glpK; PRK00047 509170001925 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 509170001926 N- and C-terminal domain interface [polypeptide binding]; other site 509170001927 active site 509170001928 MgATP binding site [chemical binding]; other site 509170001929 catalytic site [active] 509170001930 metal binding site [ion binding]; metal-binding site 509170001931 glycerol binding site [chemical binding]; other site 509170001932 homotetramer interface [polypeptide binding]; other site 509170001933 homodimer interface [polypeptide binding]; other site 509170001934 FBP binding site [chemical binding]; other site 509170001935 protein IIAGlc interface [polypeptide binding]; other site 509170001936 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 509170001937 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 509170001938 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 509170001939 active site 509170001940 substrate-binding site [chemical binding]; other site 509170001941 metal-binding site [ion binding] 509170001942 GTP binding site [chemical binding]; other site 509170001943 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001944 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001946 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170001947 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170001948 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170001949 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 4) 509170001950 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 509170001951 oligomerisation interface [polypeptide binding]; other site 509170001952 mobile loop; other site 509170001953 roof hairpin; other site 509170001954 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 509170001955 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 509170001956 ring oligomerisation interface [polypeptide binding]; other site 509170001957 ATP/Mg binding site [chemical binding]; other site 509170001958 stacking interactions; other site 509170001959 hinge regions; other site 509170001960 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 509170001961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170001962 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 509170001963 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 509170001964 putative active site [active] 509170001965 catalytic site [active] 509170001966 putative metal binding site [ion binding]; other site 509170001967 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 1) 509170001968 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 2) 509170001969 Transposase domain (DUF772); Region: DUF772; cl15789 509170001970 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001971 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 3) 509170001972 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug efflux protein (part 4) 509170001973 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 509170001974 Peptidase family M48; Region: Peptidase_M48; cl12018 509170001975 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170001976 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170001977 catalytic residue [active] 509170001978 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 509170001979 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 509170001980 Ligand Binding Site [chemical binding]; other site 509170001981 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001982 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170001983 Transposase domain (DUF772); Region: DUF772; cl15789 509170001984 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001985 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170001986 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170001987 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170001988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170001989 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 509170001990 dimer interface [polypeptide binding]; other site 509170001991 FMN binding site [chemical binding]; other site 509170001992 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 509170001993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170001994 NAD(P) binding site [chemical binding]; other site 509170001995 active site 509170001996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170001997 Helix-turn-helix domains; Region: HTH; cl00088 509170001998 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Glycerate kinase (partial) 509170001999 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002000 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002001 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 509170002002 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 509170002003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002004 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 509170002005 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 509170002006 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 509170002007 motif 1; other site 509170002008 dimer interface [polypeptide binding]; other site 509170002009 active site 509170002010 motif 2; other site 509170002011 motif 3; other site 509170002012 Tim44-like domain; Region: Tim44; cl09208 509170002013 DNA repair protein RadA; Provisional; Region: PRK11823 509170002014 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 509170002015 Walker A motif/ATP binding site; other site 509170002016 ATP binding site [chemical binding]; other site 509170002017 Walker B motif; other site 509170002018 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 509170002019 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 509170002020 diaminopimelate decarboxylase; Region: lysA; TIGR01048 509170002021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 509170002022 active site 509170002023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170002024 substrate binding site [chemical binding]; other site 509170002025 catalytic residues [active] 509170002026 dimer interface [polypeptide binding]; other site 509170002027 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 509170002028 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509170002029 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509170002030 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 509170002031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170002032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170002033 Transposase domain (DUF772); Region: DUF772; cl15789 509170002034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002035 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of LysE family transpoter (part 2) 509170002036 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of LysE family transporter (part 1) 509170002037 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 509170002038 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170002039 DNA binding site [nucleotide binding] 509170002040 Int/Topo IB signature motif; other site 509170002041 active site 509170002042 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 509170002043 Ligand binding site [chemical binding]; other site 509170002044 Electron transfer flavoprotein domain; Region: ETF; pfam01012 509170002045 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 509170002046 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 509170002047 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 509170002048 DNA gyrase subunit A; Validated; Region: PRK05560 509170002049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 509170002050 CAP-like domain; other site 509170002051 active site 509170002052 primary dimer interface [polypeptide binding]; other site 509170002053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509170002059 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170002060 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002061 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002062 GtrA-like protein; Region: GtrA; cl00971 509170002063 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of CPS-53 prophage, bactoprenol glucosyl transferase (part 2) 509170002064 Transposase domain (DUF772); Region: DUF772; cl15789 509170002065 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002066 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of CPS-53 prophage, bactoprenol glucosyl transferase (part 1) 509170002067 YdjC-like protein; Region: YdjC; cl01344 509170002068 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509170002069 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 509170002070 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 509170002071 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170002072 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170002073 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 509170002074 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 509170002075 homodimer interface [polypeptide binding]; other site 509170002076 substrate-cofactor binding pocket; other site 509170002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002078 catalytic residue [active] 509170002079 Transposase domain (DUF772); Region: DUF772; cl15789 509170002080 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002081 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 509170002082 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 509170002083 EamA-like transporter family; Region: EamA; cl01037 509170002084 EamA-like transporter family; Region: EamA; cl01037 509170002085 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 509170002086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509170002087 FtsX-like permease family; Region: FtsX; cl15850 509170002088 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 509170002089 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 509170002090 Walker A/P-loop; other site 509170002091 ATP binding site [chemical binding]; other site 509170002092 Q-loop/lid; other site 509170002093 ABC transporter signature motif; other site 509170002094 Walker B; other site 509170002095 D-loop; other site 509170002096 H-loop/switch region; other site 509170002097 Evidence 7 : Gene remnant; Product type f : factor; fragment of Competence factor involved in DNA uptake (part 1) 509170002098 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002099 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002100 Evidence 7 : Gene remnant; Product type f : factor; fragment of competence factor involved in DNA uptake (part 1) 509170002101 Evidence 7 : Gene remnant; Product type f : factor; fragment of competence factor involved in DNA uptake (part 2) 509170002102 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170002103 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 509170002104 putative acyl-acceptor binding pocket; other site 509170002105 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 509170002106 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 509170002107 tandem repeat interface [polypeptide binding]; other site 509170002108 oligomer interface [polypeptide binding]; other site 509170002109 active site residues [active] 509170002110 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 1) 509170002111 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 2) 509170002112 Transposase domain (DUF772); Region: DUF772; cl15789 509170002113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002114 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 509170002115 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 509170002116 active site 509170002117 substrate binding site [chemical binding]; other site 509170002118 cosubstrate binding site; other site 509170002119 catalytic site [active] 509170002120 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 509170002121 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 509170002122 dimerization interface [polypeptide binding]; other site 509170002123 putative ATP binding site [chemical binding]; other site 509170002124 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 509170002125 Domain of unknown function DUF20; Region: UPF0118; pfam01594 509170002126 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 509170002127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170002128 Transposase domain (DUF772); Region: DUF772; cl15789 509170002129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002130 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 509170002131 RNA polymerase factor sigma-70; Validated; Region: PRK09047 509170002132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170002133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170002134 DNA binding residues [nucleotide binding] 509170002135 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509170002136 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509170002137 fructose-1,6-bisphosphatase family protein; Region: PLN02628 509170002138 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 509170002139 AMP binding site [chemical binding]; other site 509170002140 metal binding site [ion binding]; metal-binding site 509170002141 active site 509170002142 putative outer membrane lipoprotein; Provisional; Region: PRK09967 509170002143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170002144 ligand binding site [chemical binding]; other site 509170002145 translocation protein TolB; Provisional; Region: tolB; PRK04922 509170002146 TolB amino-terminal domain; Region: TolB_N; cl00639 509170002147 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 509170002148 structural tetrad; other site 509170002149 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170002150 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509170002151 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509170002152 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170002153 active site 509170002154 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 2) 509170002155 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (part 1) 509170002156 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 509170002157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170002158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170002159 Walker A motif; other site 509170002160 ATP binding site [chemical binding]; other site 509170002161 Walker B motif; other site 509170002162 arginine finger; other site 509170002163 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 509170002164 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 509170002165 RuvA N terminal domain; Region: RuvA_N; pfam01330 509170002166 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 509170002167 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 509170002168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170002169 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 509170002170 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 509170002171 dimerization interface [polypeptide binding]; other site 509170002172 ATP binding site [chemical binding]; other site 509170002173 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 509170002174 dimerization interface [polypeptide binding]; other site 509170002175 ATP binding site [chemical binding]; other site 509170002176 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 509170002177 putative active site [active] 509170002178 catalytic triad [active] 509170002179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002180 putative substrate translocation pore; other site 509170002181 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 509170002182 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002184 enoyl-CoA hydratase; Provisional; Region: PRK06688 509170002185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170002186 substrate binding site [chemical binding]; other site 509170002187 oxyanion hole (OAH) forming residues; other site 509170002188 trimer interface [polypeptide binding]; other site 509170002189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170002190 active site 509170002191 nucleotide binding site [chemical binding]; other site 509170002192 HIGH motif; other site 509170002193 KMSKS motif; other site 509170002194 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 509170002195 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 509170002196 catalytic triad [active] 509170002197 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002198 Transposase domain (DUF772); Region: DUF772; cl15789 509170002199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002200 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002201 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 509170002202 Ligand Binding Site [chemical binding]; other site 509170002203 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 509170002204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170002205 FeS/SAM binding site; other site 509170002206 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 509170002207 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 509170002208 active site 509170002209 substrate binding site [chemical binding]; other site 509170002210 trimer interface [polypeptide binding]; other site 509170002211 CoA binding site [chemical binding]; other site 509170002212 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 509170002213 Helix-turn-helix domains; Region: HTH; cl00088 509170002214 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 509170002215 substrate binding site [chemical binding]; other site 509170002216 dimerization interface [polypeptide binding]; other site 509170002217 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 509170002218 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 509170002219 Walker A/P-loop; other site 509170002220 ATP binding site [chemical binding]; other site 509170002221 Q-loop/lid; other site 509170002222 ABC transporter signature motif; other site 509170002223 Walker B; other site 509170002224 D-loop; other site 509170002225 H-loop/switch region; other site 509170002226 TOBE-like domain; Region: TOBE_3; pfam12857 509170002227 sulfate transport protein; Provisional; Region: cysT; CHL00187 509170002228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002229 dimer interface [polypeptide binding]; other site 509170002230 conserved gate region; other site 509170002231 putative PBP binding loops; other site 509170002232 ABC-ATPase subunit interface; other site 509170002233 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 509170002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002235 dimer interface [polypeptide binding]; other site 509170002236 conserved gate region; other site 509170002237 putative PBP binding loops; other site 509170002238 ABC-ATPase subunit interface; other site 509170002239 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170002240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170002241 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 509170002242 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 509170002243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002244 catalytic residue [active] 509170002245 YceG-like family; Region: YceG; pfam02618 509170002246 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 509170002247 dimerization interface [polypeptide binding]; other site 509170002248 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 509170002249 thymidylate kinase; Validated; Region: tmk; PRK00698 509170002250 TMP-binding site; other site 509170002251 ATP-binding site [chemical binding]; other site 509170002252 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170002253 CoenzymeA binding site [chemical binding]; other site 509170002254 subunit interaction site [polypeptide binding]; other site 509170002255 PHB binding site; other site 509170002256 L-aspartate oxidase; Provisional; Region: PRK09077 509170002257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002258 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 509170002259 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 509170002260 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 509170002261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002262 protein binding site [polypeptide binding]; other site 509170002263 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002264 protein binding site [polypeptide binding]; other site 509170002265 Transposase domain (DUF772); Region: DUF772; cl15789 509170002266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002267 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170002268 active site 509170002269 GTP-binding protein LepA; Provisional; Region: PRK05433 509170002270 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 509170002271 G1 box; other site 509170002272 putative GEF interaction site [polypeptide binding]; other site 509170002273 GTP/Mg2+ binding site [chemical binding]; other site 509170002274 Switch I region; other site 509170002275 G2 box; other site 509170002276 G3 box; other site 509170002277 Switch II region; other site 509170002278 G4 box; other site 509170002279 G5 box; other site 509170002280 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 509170002281 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 509170002282 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 509170002283 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 509170002284 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509170002285 Catalytic site [active] 509170002286 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509170002287 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 509170002288 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 509170002289 dimerization interface [polypeptide binding]; other site 509170002290 active site 509170002291 metal binding site [ion binding]; metal-binding site 509170002292 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 509170002293 dsRNA binding site [nucleotide binding]; other site 509170002294 GTPase Era; Reviewed; Region: era; PRK00089 509170002295 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 509170002296 G1 box; other site 509170002297 GTP/Mg2+ binding site [chemical binding]; other site 509170002298 Switch I region; other site 509170002299 G2 box; other site 509170002300 Switch II region; other site 509170002301 G3 box; other site 509170002302 G4 box; other site 509170002303 G5 box; other site 509170002304 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 509170002305 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 509170002306 Recombination protein O N terminal; Region: RecO_N; cl15812 509170002307 Recombination protein O C terminal; Region: RecO_C; pfam02565 509170002308 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 509170002309 active site 509170002310 hydrophilic channel; other site 509170002311 dimerization interface [polypeptide binding]; other site 509170002312 catalytic residues [active] 509170002313 active site lid [active] 509170002314 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 509170002315 active site 509170002316 dinuclear metal binding site [ion binding]; other site 509170002317 dimerization interface [polypeptide binding]; other site 509170002318 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002319 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 509170002320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002321 NAD(P) binding site [chemical binding]; other site 509170002322 active site 509170002323 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002324 Transposase domain (DUF772); Region: DUF772; cl15789 509170002325 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002326 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002327 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170002328 aspartate aminotransferase; Provisional; Region: PRK05764 509170002329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002331 homodimer interface [polypeptide binding]; other site 509170002332 catalytic residue [active] 509170002333 PAS domain; Region: PAS_9; pfam13426 509170002334 PAS domain; Region: PAS_9; pfam13426 509170002335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170002336 metal binding site [ion binding]; metal-binding site 509170002337 active site 509170002338 I-site; other site 509170002339 hypothetical protein; Region: PHA00684 509170002340 excinuclease ABC subunit B; Provisional; Region: PRK05298 509170002341 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 509170002342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170002343 ATP-binding site [chemical binding]; other site 509170002344 ATP binding site [chemical binding]; other site 509170002345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170002346 nucleotide binding region [chemical binding]; other site 509170002347 ATP-binding site [chemical binding]; other site 509170002348 Ultra-violet resistance protein B; Region: UvrB; pfam12344 509170002349 UvrB/uvrC motif; Region: UVR; pfam02151 509170002350 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 509170002351 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of chloramphenicol-sensitive protein (part 1) 509170002352 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of chloramphenicol-sensitive protein (part 2) 509170002353 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 509170002354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002355 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 509170002356 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002357 GTPase CgtA; Reviewed; Region: obgE; PRK12298 509170002358 GTP1/OBG; Region: GTP1_OBG; pfam01018 509170002359 Obg GTPase; Region: Obg; cd01898 509170002360 G1 box; other site 509170002361 GTP/Mg2+ binding site [chemical binding]; other site 509170002362 Switch I region; other site 509170002363 G2 box; other site 509170002364 G3 box; other site 509170002365 Switch II region; other site 509170002366 G4 box; other site 509170002367 G5 box; other site 509170002368 gamma-glutamyl kinase; Provisional; Region: PRK05429 509170002369 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 509170002370 nucleotide binding site [chemical binding]; other site 509170002371 homotetrameric interface [polypeptide binding]; other site 509170002372 putative phosphate binding site [ion binding]; other site 509170002373 putative allosteric binding site; other site 509170002374 PUA domain; Region: PUA; cl00607 509170002375 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170002376 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 509170002377 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 509170002378 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170002379 FMN binding site [chemical binding]; other site 509170002380 active site 509170002381 catalytic residues [active] 509170002382 substrate binding site [chemical binding]; other site 509170002383 Nitronate monooxygenase; Region: NMO; pfam03060 509170002384 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 509170002385 FMN binding site [chemical binding]; other site 509170002386 substrate binding site [chemical binding]; other site 509170002387 putative catalytic residue [active] 509170002388 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 509170002389 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170002390 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding (partial) 509170002391 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509170002392 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of NADH dehydrogenase II (part 2) 509170002393 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of NADH dehydrogenase II (part 1) 509170002394 Transposase domain (DUF772); Region: DUF772; cl15789 509170002395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002396 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509170002397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170002398 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 509170002399 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 509170002400 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 509170002401 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 509170002402 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines; Region: PseudoU_synth_RluE; cd02566 509170002403 pseudouridine synthase; Region: TIGR00093 509170002404 probable active site [active] 509170002405 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509170002406 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 509170002407 ERF superfamily; Region: ERF; pfam04404 509170002408 replicative DNA helicase; Provisional; Region: PRK08840 509170002409 hypothetical protein; Provisional; Region: PRK09946 509170002410 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 509170002411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170002412 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170002413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170002414 non-specific DNA binding site [nucleotide binding]; other site 509170002415 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 509170002416 salt bridge; other site 509170002417 sequence-specific DNA binding site [nucleotide binding]; other site 509170002418 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170002419 Catalytic site [active] 509170002420 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 509170002421 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 509170002422 BRO family, N-terminal domain; Region: Bro-N; cl10591 509170002423 NinB protein; Region: NinB; cl14671 509170002424 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 509170002425 active site 509170002426 Terminase small subunit; Region: Terminase_2; cl01513 509170002427 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 509170002428 Phage Terminase; Region: Terminase_1; pfam03354 509170002429 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 509170002430 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 509170002431 Phage capsid family; Region: Phage_capsid; pfam05065 509170002432 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein 509170002433 Phage-related protein [Function unknown]; Region: COG4695; cl01923 509170002434 Phage portal protein; Region: Phage_portal; pfam04860 509170002435 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 509170002436 oligomerization interface [polypeptide binding]; other site 509170002437 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 509170002438 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 509170002439 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 509170002440 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 509170002441 ORF11CD3 domain; Region: ORF11CD3; pfam10549 509170002442 Arc-like DNA binding domain; Region: Arc; pfam03869 509170002443 AntA/AntB antirepressor; Region: AntA; cl01430 509170002444 Mu-like prophage protein [General function prediction only]; Region: COG3941 509170002445 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 509170002446 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 509170002447 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 509170002448 catalytic site [active] 509170002449 Asp-box motif; other site 509170002450 OpgC protein; Region: OpgC_C; cl00792 509170002451 Acyltransferase family; Region: Acyl_transf_3; pfam01757 509170002452 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170002453 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170002454 PAAR motif; Region: PAAR_motif; cl15808 509170002455 integrase; Provisional; Region: PRK09692 509170002456 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170002457 active site 509170002458 Int/Topo IB signature motif; other site 509170002459 Transposase domain (DUF772); Region: DUF772; cl15789 509170002460 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002461 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 1) 509170002462 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 2) 509170002463 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of isocitrate dehydrogenase (part 3) 509170002464 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein 509170002465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170002466 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 509170002467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170002468 Helix-turn-helix domains; Region: HTH; cl00088 509170002469 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 509170002470 putative dimerization interface [polypeptide binding]; other site 509170002471 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 509170002472 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509170002473 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 509170002474 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509170002475 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509170002476 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509170002477 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170002478 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509170002479 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170002480 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 509170002481 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002482 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002483 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002484 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002485 Protein of unknown function (DUF962); Region: DUF962; cl01879 509170002486 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509170002487 thiamine phosphate binding site [chemical binding]; other site 509170002488 active site 509170002489 pyrophosphate binding site [ion binding]; other site 509170002490 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 509170002491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170002492 inhibitor-cofactor binding pocket; inhibition site 509170002493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002494 catalytic residue [active] 509170002495 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (part 1) 509170002496 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (part 2) 509170002497 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 509170002498 active site 509170002499 ATP-dependent helicase HepA; Validated; Region: PRK04914 509170002500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170002501 ATP binding site [chemical binding]; other site 509170002502 putative Mg++ binding site [ion binding]; other site 509170002503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170002504 nucleotide binding region [chemical binding]; other site 509170002505 ATP-binding site [chemical binding]; other site 509170002506 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002508 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002509 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002510 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 509170002511 Helix-turn-helix domains; Region: HTH; cl00088 509170002512 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 509170002513 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170002514 FAD binding pocket [chemical binding]; other site 509170002515 FAD binding motif [chemical binding]; other site 509170002516 phosphate binding motif [ion binding]; other site 509170002517 beta-alpha-beta structure motif; other site 509170002518 NAD binding pocket [chemical binding]; other site 509170002519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170002520 catalytic loop [active] 509170002521 iron binding site [ion binding]; other site 509170002522 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509170002523 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 509170002524 putative di-iron ligands [ion binding]; other site 509170002525 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170002526 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 1) 509170002527 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 2) 509170002528 Transposase domain (DUF772); Region: DUF772; cl15789 509170002529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002530 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator protein (LysR family) (part 3) 509170002531 Protein of unknown function (DUF541); Region: SIMPL; cl01077 509170002532 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 509170002533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170002534 inhibitor-cofactor binding pocket; inhibition site 509170002535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002536 catalytic residue [active] 509170002537 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 509170002538 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 509170002539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170002540 catalytic residue [active] 509170002541 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aldehyde dehydrogenase (part 1) 509170002542 Transposase domain (DUF772); Region: DUF772; cl15789 509170002543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002544 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aldehyde dehydrogenase (part 2) 509170002545 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170002546 Helix-turn-helix domains; Region: HTH; cl00088 509170002547 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 509170002548 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 509170002549 dimer interface [polypeptide binding]; other site 509170002550 PYR/PP interface [polypeptide binding]; other site 509170002551 TPP binding site [chemical binding]; other site 509170002552 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 509170002553 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 509170002554 TPP-binding site [chemical binding]; other site 509170002555 dimer interface [polypeptide binding]; other site 509170002556 Evidence 7 : Gene remnant; PubMedId : 2408019; Product type t : transporter; fragment of aromatic amino acid transporter (AroP) (APC family) (part 1) 509170002557 Evidence 7 : Gene remnant; PubMedId : 2408019; Product type t : transporter; fragment of aromatic amino acid transporter (APC family) (AroP)(part 2) 509170002558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170002559 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 509170002560 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 509170002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002562 dimer interface [polypeptide binding]; other site 509170002563 conserved gate region; other site 509170002564 putative PBP binding loops; other site 509170002565 ABC-ATPase subunit interface; other site 509170002566 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 509170002567 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 509170002568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170002569 dimer interface [polypeptide binding]; other site 509170002570 conserved gate region; other site 509170002571 putative PBP binding loops; other site 509170002572 ABC-ATPase subunit interface; other site 509170002573 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 509170002574 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 509170002575 Walker A/P-loop; other site 509170002576 ATP binding site [chemical binding]; other site 509170002577 Q-loop/lid; other site 509170002578 ABC transporter signature motif; other site 509170002579 Walker B; other site 509170002580 D-loop; other site 509170002581 H-loop/switch region; other site 509170002582 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 509170002583 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 509170002584 tandem repeat interface [polypeptide binding]; other site 509170002585 oligomer interface [polypeptide binding]; other site 509170002586 active site residues [active] 509170002587 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002589 Transposase domain (DUF772); Region: DUF772; cl15789 509170002590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002591 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170002592 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 509170002593 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 509170002594 putative active site [active] 509170002595 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509170002596 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 509170002597 Walker A/P-loop; other site 509170002598 ATP binding site [chemical binding]; other site 509170002599 Q-loop/lid; other site 509170002600 ABC transporter signature motif; other site 509170002601 Walker B; other site 509170002602 D-loop; other site 509170002603 H-loop/switch region; other site 509170002604 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509170002605 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170002606 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170002607 Uncharacterized conserved protein [Function unknown]; Region: COG1739 509170002608 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 509170002609 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509170002610 putative trimer interface [polypeptide binding]; other site 509170002611 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 509170002612 trimer interface [polypeptide binding]; other site 509170002613 active site 509170002614 substrate binding site [chemical binding]; other site 509170002615 putative CoA binding site [chemical binding]; other site 509170002616 CoA binding site [chemical binding]; other site 509170002617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 509170002618 Ligand Binding Site [chemical binding]; other site 509170002619 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 509170002620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 509170002622 Ferredoxin [Energy production and conversion]; Region: COG1146 509170002623 4Fe-4S binding domain; Region: Fer4; cl02805 509170002624 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 509170002625 Predicted acetyltransferase [General function prediction only]; Region: COG3153 509170002626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170002627 Coenzyme A binding pocket [chemical binding]; other site 509170002628 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 509170002629 MutS domain I; Region: MutS_I; pfam01624 509170002630 MutS domain II; Region: MutS_II; pfam05188 509170002631 MutS family domain IV; Region: MutS_IV; pfam05190 509170002632 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 509170002633 Walker A/P-loop; other site 509170002634 ATP binding site [chemical binding]; other site 509170002635 Q-loop/lid; other site 509170002636 ABC transporter signature motif; other site 509170002637 Walker B; other site 509170002638 D-loop; other site 509170002639 H-loop/switch region; other site 509170002640 integrase; Provisional; Region: PRK09692 509170002641 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170002642 active site 509170002643 Int/Topo IB signature motif; other site 509170002644 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002645 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002646 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 509170002647 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 509170002648 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 509170002649 adenylosuccinate lyase; Provisional; Region: PRK09285 509170002650 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 509170002651 tetramer interface [polypeptide binding]; other site 509170002652 active site 509170002653 Protein of unknown function (DUF489); Region: DUF489; cl01097 509170002654 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 509170002655 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 509170002656 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 509170002657 nudix motif; other site 509170002658 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 509170002659 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509170002660 trimer interface [polypeptide binding]; other site 509170002661 putative metal binding site [ion binding]; other site 509170002662 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509170002663 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170002664 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 509170002665 Survival protein SurE; Region: SurE; cl00448 509170002666 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170002667 putative peptidoglycan binding site; other site 509170002668 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 509170002669 transcriptional regulator; Provisional; Region: PRK10632 509170002670 Helix-turn-helix domains; Region: HTH; cl00088 509170002671 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 509170002672 putative effector binding pocket; other site 509170002673 dimerization interface [polypeptide binding]; other site 509170002674 AAA domain; Region: AAA_32; pfam13654 509170002675 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 509170002676 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 509170002677 muropeptide transporter; Validated; Region: ampG; PRK11010 509170002678 AmpG-related permease; Region: 2A0125; TIGR00901 509170002679 muropeptide transporter; Validated; Region: ampG; PRK11010 509170002680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170002681 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 509170002682 dimer interface [polypeptide binding]; other site 509170002683 active site 509170002684 metal binding site [ion binding]; metal-binding site 509170002685 glutathione binding site [chemical binding]; other site 509170002686 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 509170002687 Membrane transport protein; Region: Mem_trans; cl09117 509170002688 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 509170002689 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002690 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002691 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170002692 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002693 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 509170002695 Radical SAM superfamily; Region: Radical_SAM; pfam04055 509170002696 elongation factor P; Validated; Region: PRK00529 509170002697 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 509170002698 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 509170002699 RNA binding site [nucleotide binding]; other site 509170002700 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 509170002701 RNA binding site [nucleotide binding]; other site 509170002702 carbon starvation protein A; Provisional; Region: PRK15015 509170002703 Carbon starvation protein CstA; Region: CstA; pfam02554 509170002704 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 509170002705 Protein of unknown function (DUF466); Region: DUF466; cl01082 509170002706 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002708 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 509170002709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 509170002710 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 509170002711 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 509170002712 substrate binding site [chemical binding]; other site 509170002713 active site 509170002714 Protein of unknown function (DUF817); Region: DUF817; cl01520 509170002715 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 509170002716 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 2) 509170002717 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide (part 3) 509170002718 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Beta-lactamase precursor (Cephalosporinase) (partial) 509170002719 Transposase domain (DUF772); Region: DUF772; cl15789 509170002720 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002721 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 509170002722 homodecamer interface [polypeptide binding]; other site 509170002723 GTP cyclohydrolase I; Provisional; Region: PLN03044 509170002724 active site 509170002725 putative catalytic site residues [active] 509170002726 zinc binding site [ion binding]; other site 509170002727 GTP-CH-I/GFRP interaction surface; other site 509170002728 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 509170002729 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 509170002730 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 509170002731 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 509170002732 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 509170002733 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 509170002734 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 509170002735 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 509170002736 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 509170002737 XdhC Rossmann domain; Region: XdhC_C; pfam13478 509170002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 509170002739 Smr domain; Region: Smr; cl02619 509170002740 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 509170002741 active site 509170002742 ribulose/triose binding site [chemical binding]; other site 509170002743 phosphate binding site [ion binding]; other site 509170002744 substrate (anthranilate) binding pocket [chemical binding]; other site 509170002745 product (indole) binding pocket [chemical binding]; other site 509170002746 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 509170002747 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509170002748 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509170002749 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of TonB-dependent receptor (part 1) 509170002750 Transposase domain (DUF772); Region: DUF772; cl15789 509170002751 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002752 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of TonB-dependent receptor (part 2) 509170002753 Peptidase family M1; Region: Peptidase_M1; pfam01433 509170002754 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 509170002755 Zn binding site [ion binding]; other site 509170002756 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 509170002757 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509170002758 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509170002759 glutamine binding [chemical binding]; other site 509170002760 catalytic triad [active] 509170002761 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 509170002762 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170002763 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002764 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002765 glutamine synthetase; Provisional; Region: glnA; PRK09469 509170002766 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 509170002767 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509170002768 UTRA domain; Region: UTRA; cl01230 509170002769 UbiA prenyltransferase family; Region: UbiA; cl00337 509170002770 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170002771 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170002772 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170002773 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 509170002774 superoxide dismutase; Provisional; Region: PRK10543 509170002775 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 509170002776 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 509170002777 Uncharacterized conserved protein [Function unknown]; Region: COG0327 509170002778 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 509170002779 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170002780 protein binding site [polypeptide binding]; other site 509170002781 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 509170002782 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509170002783 active site 509170002784 NTP binding site [chemical binding]; other site 509170002785 metal binding triad [ion binding]; metal-binding site 509170002786 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509170002787 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 509170002788 Malic enzyme, N-terminal domain; Region: malic; pfam00390 509170002789 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 509170002790 putative NAD(P) binding site [chemical binding]; other site 509170002791 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 509170002792 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 509170002793 PAS domain S-box; Region: sensory_box; TIGR00229 509170002794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509170002795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170002796 metal binding site [ion binding]; metal-binding site 509170002797 active site 509170002798 I-site; other site 509170002799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509170002800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 509170002801 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 509170002802 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 509170002803 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 509170002804 FAD binding site [chemical binding]; other site 509170002805 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 509170002806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002807 oligomerization interface [polypeptide binding]; other site 509170002808 active site 509170002809 NAD+ binding site [chemical binding]; other site 509170002810 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 509170002811 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 509170002812 Transposase domain (DUF772); Region: DUF772; cl15789 509170002813 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002814 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 509170002815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170002816 active site 509170002817 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 509170002818 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002819 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002820 Transposase domain (DUF772); Region: DUF772; cl15789 509170002821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002822 lipoyl synthase; Provisional; Region: PRK05481 509170002823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170002824 FeS/SAM binding site; other site 509170002825 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 509170002826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170002828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509170002829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170002830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170002831 putative substrate translocation pore; other site 509170002832 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of nitrate transporter transmembrane protein (MFS superfamily) (part 2) 509170002833 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of nitrate transporter transmembrane protein (MFS superfamily) (part 1) 509170002834 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 509170002835 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509170002836 active site 509170002837 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 509170002838 rRNA interaction site [nucleotide binding]; other site 509170002839 S8 interaction site; other site 509170002840 putative laminin-1 binding site; other site 509170002841 elongation factor Ts; Provisional; Region: tsf; PRK09377 509170002842 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 509170002843 Elongation factor TS; Region: EF_TS; pfam00889 509170002844 Elongation factor TS; Region: EF_TS; pfam00889 509170002845 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 509170002846 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC/XylS family) (part 1) 509170002847 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC/XylS family) (part 2) 509170002848 AzlC protein; Region: AzlC; cl00570 509170002849 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002851 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 509170002852 Transglycosylase SLT domain; Region: SLT_2; pfam13406 509170002853 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170002854 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170002855 catalytic residue [active] 509170002856 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 509170002857 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 509170002858 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509170002859 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509170002860 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509170002861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170002862 Walker A/P-loop; other site 509170002863 ATP binding site [chemical binding]; other site 509170002864 Q-loop/lid; other site 509170002865 ABC transporter signature motif; other site 509170002866 Walker B; other site 509170002867 D-loop; other site 509170002868 H-loop/switch region; other site 509170002869 integrase; Provisional; Region: int; PHA02601 509170002870 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170002871 DNA binding site [nucleotide binding] 509170002872 Int/Topo IB signature motif; other site 509170002873 active site 509170002874 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170002875 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002876 Evidence 7 : Gene remnant; PubMedId : 3313284; Product type t : transporter; fragment of histidine permease (ABC superfamily, atp_bind) (HisP) (part 1) 509170002877 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisM) (part 2) 509170002878 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisM) (part 1) 509170002879 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisQ) (part2) 509170002880 Evidence 7 : Gene remnant; PubMedId : 7050725; Product type t : transporter; fragment of Histidine transport system permease protein (ABC superfamily, membrane) (HisQ) (part 1) 509170002881 Transposase domain (DUF772); Region: DUF772; cl15789 509170002882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002883 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 2) 509170002884 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 1) 509170002885 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 509170002886 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509170002887 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170002888 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 509170002889 FAD binding pocket [chemical binding]; other site 509170002890 FAD binding motif [chemical binding]; other site 509170002891 phosphate binding motif [ion binding]; other site 509170002892 beta-alpha-beta structure motif; other site 509170002893 NAD binding pocket [chemical binding]; other site 509170002894 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 509170002895 homodimer interaction site [polypeptide binding]; other site 509170002896 cofactor binding site; other site 509170002897 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 2) 509170002898 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 1) 509170002899 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 509170002900 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 509170002901 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 509170002902 Walker A motif; other site 509170002903 ATP binding site [chemical binding]; other site 509170002904 Walker B motif; other site 509170002905 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 509170002906 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509170002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170002908 active site 509170002909 phosphorylation site [posttranslational modification] 509170002910 intermolecular recognition site; other site 509170002911 dimerization interface [polypeptide binding]; other site 509170002912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170002913 DNA binding site [nucleotide binding] 509170002914 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of two-component system sensor protein (part 1) 509170002915 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of two-component system sensor protein (part 2) 509170002916 hypothetical protein; Provisional; Region: PRK08999 509170002917 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 509170002918 active site 509170002919 8-oxo-dGMP binding site [chemical binding]; other site 509170002920 nudix motif; other site 509170002921 metal binding site [ion binding]; metal-binding site 509170002922 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 509170002923 active site 509170002924 pyrophosphate binding site [ion binding]; other site 509170002925 thiamine phosphate binding site [chemical binding]; other site 509170002926 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 509170002927 Transglycosylase; Region: Transgly; cl07896 509170002928 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170002929 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 509170002930 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 509170002931 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 509170002932 hypothetical protein; Validated; Region: PRK09071 509170002933 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509170002934 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509170002935 Evidence 7 : Gene remnant; Product type t : transporter; fragment of aerobic C4-dicarboxylate transport protein (part 1) 509170002936 Transposase domain (DUF772); Region: DUF772; cl15789 509170002937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002938 Evidence 7 : Gene remnant; Product type t : transporter; fragment of aerobic C4-dicarboxylate transport protein (part 2) 509170002939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170002940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170002941 active site 509170002942 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170002943 Chorismate mutase type II; Region: CM_2; cl00693 509170002944 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 509170002945 Prephenate dehydratase; Region: PDT; pfam00800 509170002946 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 509170002947 putative L-Phe binding site [chemical binding]; other site 509170002948 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 509170002949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002950 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 509170002951 hinge; other site 509170002952 active site 509170002953 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 509170002954 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 509170002955 metal binding site [ion binding]; metal-binding site 509170002956 dimer interface [polypeptide binding]; other site 509170002957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170002958 Evidence 7 : Gene remnant; Product type r : regulator; fragment of Transcriptional regulatory protein RtcR (part 1) 509170002959 Evidence 7 : Gene remnant; Product type r : regulator; fragment of Transcriptional regulatory protein RtcR (part 2) 509170002960 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 509170002961 Protein of unknown function (DUF328); Region: DUF328; cl01143 509170002962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170002963 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 509170002964 ThiS interaction site; other site 509170002965 putative active site [active] 509170002966 tetramer interface [polypeptide binding]; other site 509170002967 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 509170002968 thiS-thiF/thiG interaction site; other site 509170002969 Protein of unknown function (DUF423); Region: DUF423; cl01008 509170002970 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 509170002971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509170002972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170002973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 509170002974 DNA binding residues [nucleotide binding] 509170002975 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 509170002976 CPxP motif; other site 509170002977 Transposase domain (DUF772); Region: DUF772; cl15789 509170002978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170002979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 509170002980 DNA-binding site [nucleotide binding]; DNA binding site 509170002981 RNA-binding motif; other site 509170002982 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 509170002983 DEAD-like helicases superfamily; Region: DEXDc; smart00487 509170002984 ATP binding site [chemical binding]; other site 509170002985 Mg++ binding site [ion binding]; other site 509170002986 motif III; other site 509170002987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170002988 nucleotide binding region [chemical binding]; other site 509170002989 ATP-binding site [chemical binding]; other site 509170002990 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 509170002991 putative FMN binding site [chemical binding]; other site 509170002992 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 509170002993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170002994 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 509170002995 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170002996 catalytic core [active] 509170002997 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 509170002998 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 509170002999 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 509170003000 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 509170003001 quinone interaction residues [chemical binding]; other site 509170003002 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 509170003003 active site 509170003004 catalytic residues [active] 509170003005 FMN binding site [chemical binding]; other site 509170003006 substrate binding site [chemical binding]; other site 509170003007 Colicin V production protein; Region: Colicin_V; cl00567 509170003008 amidophosphoribosyltransferase; Provisional; Region: PRK09246 509170003009 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 509170003010 active site 509170003011 tetramer interface [polypeptide binding]; other site 509170003012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170003013 active site 509170003014 Peptidase family M48; Region: Peptidase_M48; cl12018 509170003015 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 509170003016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003017 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 509170003018 Peptidase family M48; Region: Peptidase_M48; cl12018 509170003019 GatB domain; Region: GatB_Yqey; cl11497 509170003020 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 509170003021 UGMP family protein; Validated; Region: PRK09604 509170003022 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 509170003023 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 509170003024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003025 Walker A motif; other site 509170003026 ATP binding site [chemical binding]; other site 509170003027 Walker B motif; other site 509170003028 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 509170003029 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 509170003030 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509170003031 active site 509170003032 nucleophile elbow; other site 509170003033 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003034 substrate binding site [chemical binding]; other site 509170003035 activation loop (A-loop); other site 509170003036 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003037 Transposase domain (DUF772); Region: DUF772; cl15789 509170003038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003039 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of hemolysin activator protein (part 1) 509170003040 Transposase domain (DUF772); Region: DUF772; cl15789 509170003041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003042 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of hemolysin activator protein (part 2) 509170003043 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 1) 509170003044 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 2) 509170003045 Transposase domain (DUF772); Region: DUF772; cl15789 509170003046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003047 Evidence 7 : Gene remnant; Product type ps : structure; fragment of hemagglutinin/hemolysin-related protein (part 3) 509170003048 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003049 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003051 Transposase domain (DUF772); Region: DUF772; cl15789 509170003052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003053 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of HTH-type transcriptional regulator (AraC family) (partial) 509170003054 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 509170003055 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 509170003056 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 509170003057 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003058 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003059 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003060 Transposase domain (DUF772); Region: DUF772; cl15789 509170003061 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003062 proline/glycine betaine transporter; Provisional; Region: PRK10642 509170003063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003064 putative substrate translocation pore; other site 509170003065 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 509170003066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170003067 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003069 EamA-like transporter family; Region: EamA; cl01037 509170003070 EamA-like transporter family; Region: EamA; cl01037 509170003071 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 2) 509170003072 Transposase domain (DUF772); Region: DUF772; cl15789 509170003073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003074 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 1) 509170003075 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003077 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170003079 non-specific DNA binding site [nucleotide binding]; other site 509170003080 salt bridge; other site 509170003081 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170003082 sequence-specific DNA binding site [nucleotide binding]; other site 509170003083 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170003084 Catalytic site [active] 509170003085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170003086 cofactor binding site; other site 509170003087 DNA binding site [nucleotide binding] 509170003088 substrate interaction site [chemical binding]; other site 509170003089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170003090 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 509170003091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 509170003092 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 509170003093 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003094 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003095 Transposase domain (DUF772); Region: DUF772; cl15789 509170003096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003097 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase from bacteriophage (partial) 509170003098 Cell division protein ZapA; Region: ZapA; cl01146 509170003099 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 509170003100 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 509170003101 proline aminopeptidase P II; Provisional; Region: PRK10879 509170003102 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 509170003103 active site 509170003104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003105 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 509170003106 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 509170003107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003108 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 509170003109 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509170003110 DNA binding residues [nucleotide binding] 509170003111 Cation efflux family; Region: Cation_efflux; cl00316 509170003112 LysE type translocator; Region: LysE; cl00565 509170003113 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 509170003114 Helix-turn-helix domains; Region: HTH; cl00088 509170003115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170003116 dimerization interface [polypeptide binding]; other site 509170003117 Predicted methyltransferases [General function prediction only]; Region: COG0313 509170003118 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 509170003119 Restriction endonuclease; Region: Mrr_cat; cl00516 509170003120 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 509170003121 BON domain; Region: BON; cl02771 509170003122 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170003123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170003124 substrate binding pocket [chemical binding]; other site 509170003125 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170003126 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 509170003127 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 509170003128 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 509170003129 putative NADH binding site [chemical binding]; other site 509170003130 putative active site [active] 509170003131 nudix motif; other site 509170003132 putative metal binding site [ion binding]; other site 509170003133 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170003134 Transposase domain (DUF772); Region: DUF772; cl15789 509170003135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003136 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170003137 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 509170003138 RNA/DNA hybrid binding site [nucleotide binding]; other site 509170003139 active site 509170003140 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 509170003141 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 509170003142 active site 509170003143 substrate binding site [chemical binding]; other site 509170003144 catalytic site [active] 509170003145 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 509170003146 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170003147 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170003148 catalytic residue [active] 509170003149 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003150 putative peptidoglycan binding site; other site 509170003151 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003152 putative peptidoglycan binding site; other site 509170003153 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003154 putative peptidoglycan binding site; other site 509170003155 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003156 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003157 putative peptidoglycan binding site; other site 509170003158 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003159 putative peptidoglycan binding site; other site 509170003160 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003161 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003162 putative peptidoglycan binding site; other site 509170003163 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509170003164 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170003165 putative peptidoglycan binding site; other site 509170003166 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 509170003167 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, peri_bind) (partial) 509170003168 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003170 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, atp_bind) (part 1) 509170003171 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of oligopeptide transport protein (ABC superfamily, atp_bind) (part 2) 509170003172 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 509170003173 putative active site [active] 509170003174 putative FMN binding site [chemical binding]; other site 509170003175 putative substrate binding site [chemical binding]; other site 509170003176 putative catalytic residue [active] 509170003177 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of TonB-dependent siderophore receptor precursor (part 2) 509170003178 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003179 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003180 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of TonB-dependent siderophore receptor precursor (part 1) 509170003181 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 509170003182 dimer interface [polypeptide binding]; other site 509170003183 putative active site [active] 509170003184 putative substrate binding site [chemical binding]; other site 509170003185 catalytic site [active] 509170003186 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 509170003187 active site 509170003188 substrate binding pocket [chemical binding]; other site 509170003189 dimer interface [polypeptide binding]; other site 509170003190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170003191 metal binding site [ion binding]; metal-binding site 509170003192 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170003193 Transposase domain (DUF772); Region: DUF772; cl15789 509170003194 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003195 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170003196 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 509170003197 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 509170003198 ANP binding site [chemical binding]; other site 509170003199 Substrate Binding Site II [chemical binding]; other site 509170003200 Substrate Binding Site I [chemical binding]; other site 509170003201 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003202 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003203 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 509170003204 active site 509170003205 FMN binding site [chemical binding]; other site 509170003206 2,4-decadienoyl-CoA binding site; other site 509170003207 catalytic residue [active] 509170003208 4Fe-4S cluster binding site [ion binding]; other site 509170003209 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 509170003210 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 509170003211 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 509170003212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170003213 DNA binding site [nucleotide binding] 509170003214 Int/Topo IB signature motif; other site 509170003215 active site 509170003216 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003217 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003218 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 509170003219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003220 Surface antigen; Region: Bac_surface_Ag; cl03097 509170003221 RTX toxin acyltransferase family; Region: HlyC; cl01131 509170003222 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003223 HTH-like domain; Region: HTH_21; pfam13276 509170003224 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003225 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 509170003227 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170003228 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 509170003229 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 509170003230 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170003231 RHS Repeat; Region: RHS_repeat; cl11982 509170003232 RHS Repeat; Region: RHS_repeat; cl11982 509170003233 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 509170003234 RHS Repeat; Region: RHS_repeat; cl11982 509170003235 RHS protein; Region: RHS; pfam03527 509170003236 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 509170003237 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003239 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003240 Transposase domain (DUF772); Region: DUF772; cl15789 509170003241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003242 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003243 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003245 aromatic amino acid transporter; Provisional; Region: PRK10238 509170003246 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003248 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (AraC family) 509170003249 EamA-like transporter family; Region: EamA; cl01037 509170003250 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170003251 EamA-like transporter family; Region: EamA; cl01037 509170003252 galactarate dehydratase; Region: galactar-dH20; TIGR03248 509170003253 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 509170003254 Evidence 7 : Gene remnant; Product type t : transporter; fragment of D-glucarate/D-galactarate permease (MFS superfamily) (part 2) 509170003255 Evidence 7 : Gene remnant; Product type t : transporter; fragment of D-glucarate/D-galactarate permease (MFS superfamily) (part 1) 509170003256 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 509170003257 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 509170003258 active site 509170003259 tetramer interface [polypeptide binding]; other site 509170003260 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 509170003261 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 509170003262 putative active site [active] 509170003263 catalytic residue [active] 509170003264 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170003265 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 509170003266 dimer interface [polypeptide binding]; other site 509170003267 NADP binding site [chemical binding]; other site 509170003268 catalytic residues [active] 509170003269 Transcriptional regulators [Transcription]; Region: FadR; COG2186 509170003270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170003271 DNA-binding site [nucleotide binding]; DNA binding site 509170003272 FCD domain; Region: FCD; cl11656 509170003273 Tannase and feruloyl esterase; Region: Tannase; pfam07519 509170003274 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003275 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003276 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003277 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170003278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170003279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003280 Leucine carboxyl methyltransferase; Region: LCM; cl01306 509170003281 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 509170003282 classical (c) SDRs; Region: SDR_c; cd05233 509170003283 short chain dehydrogenase; Provisional; Region: PRK05650 509170003284 NAD(P) binding site [chemical binding]; other site 509170003285 active site 509170003286 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170003287 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170003288 Helix-turn-helix domains; Region: HTH; cl00088 509170003289 Pirin-related protein [General function prediction only]; Region: COG1741 509170003290 Cupin domain; Region: Cupin_2; cl09118 509170003291 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170003292 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170003293 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of short-chain dehydrogenase (partial) 509170003294 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003295 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003296 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 509170003297 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 509170003298 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 509170003299 active site 509170003300 purine riboside binding site [chemical binding]; other site 509170003301 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 509170003302 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 509170003303 RNA/DNA hybrid binding site [nucleotide binding]; other site 509170003304 active site 509170003305 Global regulator protein family; Region: CsrA; cl00670 509170003306 aspartate kinase; Reviewed; Region: PRK06635 509170003307 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 509170003308 putative nucleotide binding site [chemical binding]; other site 509170003309 putative catalytic residues [active] 509170003310 putative Mg ion binding site [ion binding]; other site 509170003311 putative aspartate binding site [chemical binding]; other site 509170003312 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 509170003313 putative allosteric regulatory site; other site 509170003314 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 509170003315 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 509170003316 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 509170003317 motif 1; other site 509170003318 active site 509170003319 motif 2; other site 509170003320 motif 3; other site 509170003321 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 509170003322 DHHA1 domain; Region: DHHA1; pfam02272 509170003323 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 509170003324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003325 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 509170003326 Transposase domain (DUF772); Region: DUF772; cl15789 509170003327 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003328 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 509170003329 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 509170003330 dimer interface [polypeptide binding]; other site 509170003331 motif 1; other site 509170003332 active site 509170003333 motif 2; other site 509170003334 motif 3; other site 509170003335 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 509170003336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170003337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170003338 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003339 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003340 Peptidase family M48; Region: Peptidase_M48; cl12018 509170003341 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 509170003342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170003343 active site 509170003344 catalytic tetrad [active] 509170003345 Transposase domain (DUF772); Region: DUF772; cl15789 509170003346 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003347 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 1) 509170003348 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator; aminopeptidase] (part 2) 509170003349 putative protease; Provisional; Region: PRK15452 509170003350 Peptidase family U32; Region: Peptidase_U32; cl03113 509170003351 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 509170003352 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003353 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003354 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170003355 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170003356 PAAR motif; Region: PAAR_motif; cl15808 509170003357 PAAR motif; Region: PAAR_motif; cl15808 509170003358 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003360 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 509170003361 exodeoxyribonuclease X; Provisional; Region: PRK07983 509170003362 active site 509170003363 substrate binding site [chemical binding]; other site 509170003364 catalytic site [active] 509170003365 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 509170003366 Secretory lipase; Region: LIP; pfam03583 509170003367 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 509170003368 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 509170003369 dimer interface [polypeptide binding]; other site 509170003370 glycine-pyridoxal phosphate binding site [chemical binding]; other site 509170003371 active site 509170003372 folate binding site [chemical binding]; other site 509170003373 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of Outer membrane efflux protein (part 2) 509170003374 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of Outer membrane efflux protein (part 1) 509170003375 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 509170003376 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170003377 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170003378 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170003379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003380 Helix-turn-helix domains; Region: HTH; cl00088 509170003381 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 509170003382 putative effector binding pocket; other site 509170003383 putative dimerization interface [polypeptide binding]; other site 509170003384 Evidence 7 : Gene remnant; Product type t : transporter; fragment of Lysine-arginine-ornithine-histidine-binding periplasmic protein precursor (ABC superfamily, peri_bind) (partial) 509170003385 Transposase domain (DUF772); Region: DUF772; cl15789 509170003386 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003387 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170003389 Coenzyme A binding pocket [chemical binding]; other site 509170003390 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170003391 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 509170003392 glycerol kinase (GK) interaction site [polypeptide binding]; other site 509170003393 active site 509170003394 phosphorylation site [posttranslational modification] 509170003395 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 509170003396 Clp amino terminal domain; Region: Clp_N; pfam02861 509170003397 Clp amino terminal domain; Region: Clp_N; pfam02861 509170003398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003399 Walker A motif; other site 509170003400 ATP binding site [chemical binding]; other site 509170003401 Walker B motif; other site 509170003402 arginine finger; other site 509170003403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003404 Walker A motif; other site 509170003405 ATP binding site [chemical binding]; other site 509170003406 Walker B motif; other site 509170003407 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 509170003408 Transposase domain (DUF772); Region: DUF772; cl15789 509170003409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003410 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003411 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 509170003412 THUMP domain; Region: THUMP; cl12076 509170003413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170003415 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 509170003416 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509170003417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003418 dihydroorotase; Validated; Region: pyrC; PRK09357 509170003419 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 509170003420 active site 509170003421 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170003422 ligand binding site [chemical binding]; other site 509170003423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003424 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 509170003425 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 509170003426 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 509170003427 putative C-terminal domain interface [polypeptide binding]; other site 509170003428 putative GSH binding site (G-site) [chemical binding]; other site 509170003429 putative dimer interface [polypeptide binding]; other site 509170003430 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 509170003431 putative N-terminal domain interface [polypeptide binding]; other site 509170003432 putative dimer interface [polypeptide binding]; other site 509170003433 putative substrate binding pocket (H-site) [chemical binding]; other site 509170003434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170003435 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 509170003436 Lamin Tail Domain; Region: LTD; pfam00932 509170003437 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 509170003438 generic binding surface II; other site 509170003439 generic binding surface I; other site 509170003440 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 509170003441 putative active site [active] 509170003442 putative catalytic site [active] 509170003443 putative Mg binding site IVb [ion binding]; other site 509170003444 putative phosphate binding site [ion binding]; other site 509170003445 putative DNA binding site [nucleotide binding]; other site 509170003446 putative Mg binding site IVa [ion binding]; other site 509170003447 glutathionine S-transferase; Provisional; Region: PRK10542 509170003448 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 509170003449 C-terminal domain interface [polypeptide binding]; other site 509170003450 GSH binding site (G-site) [chemical binding]; other site 509170003451 dimer interface [polypeptide binding]; other site 509170003452 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 509170003453 dimer interface [polypeptide binding]; other site 509170003454 N-terminal domain interface [polypeptide binding]; other site 509170003455 substrate binding pocket (H-site) [chemical binding]; other site 509170003456 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 509170003457 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 509170003458 catalytic residue [active] 509170003459 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 509170003460 catalytic residues [active] 509170003461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170003462 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003463 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003464 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 509170003465 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 509170003466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170003467 S-adenosylmethionine binding site [chemical binding]; other site 509170003468 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003469 peroxiredoxin; Region: AhpC; TIGR03137 509170003470 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 509170003471 dimer interface [polypeptide binding]; other site 509170003472 decamer (pentamer of dimers) interface [polypeptide binding]; other site 509170003473 catalytic triad [active] 509170003474 peroxidatic and resolving cysteines [active] 509170003475 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 509170003476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170003477 ATP binding site [chemical binding]; other site 509170003478 putative Mg++ binding site [ion binding]; other site 509170003479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170003480 nucleotide binding region [chemical binding]; other site 509170003481 ATP-binding site [chemical binding]; other site 509170003482 Helicase associated domain (HA2); Region: HA2; cl04503 509170003483 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 509170003484 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 509170003485 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 509170003486 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 509170003487 dimer interface [polypeptide binding]; other site 509170003488 active site 509170003489 CoA binding pocket [chemical binding]; other site 509170003490 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003492 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Benzoate 1,2 dioxygenase beta subunit (benB) 509170003493 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 509170003494 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 509170003495 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 509170003496 putative alpha subunit interface [polypeptide binding]; other site 509170003497 putative active site [active] 509170003498 putative substrate binding site [chemical binding]; other site 509170003499 Fe binding site [ion binding]; other site 509170003500 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170003501 Helix-turn-helix domains; Region: HTH; cl00088 509170003502 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 509170003503 dimerizarion interface [polypeptide binding]; other site 509170003504 CrgA pocket; other site 509170003505 substrate binding pocket [chemical binding]; other site 509170003506 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003507 metal-binding site [ion binding] 509170003508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003509 metal-binding site [ion binding] 509170003510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509170003511 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509170003512 metal-binding site [ion binding] 509170003513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170003514 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170003515 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 509170003516 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 509170003517 DNA binding residues [nucleotide binding] 509170003518 dimer interface [polypeptide binding]; other site 509170003519 copper binding site [ion binding]; other site 509170003520 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170003521 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 509170003522 dimerization interface [polypeptide binding]; other site 509170003523 Transposase domain (DUF772); Region: DUF772; cl15789 509170003524 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003525 Evidence 7 : Gene remnant; Product type t : transporter; fragment of C4-dicarboxylate transport protein (partial) 509170003526 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003528 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 509170003529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170003530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170003531 dimer interface [polypeptide binding]; other site 509170003532 conserved gate region; other site 509170003533 ABC-ATPase subunit interface; other site 509170003534 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509170003535 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 509170003536 Walker A/P-loop; other site 509170003537 ATP binding site [chemical binding]; other site 509170003538 Q-loop/lid; other site 509170003539 ABC transporter signature motif; other site 509170003540 Walker B; other site 509170003541 D-loop; other site 509170003542 H-loop/switch region; other site 509170003543 NIL domain; Region: NIL; cl09633 509170003544 NMT1-like family; Region: NMT1_2; cl15260 509170003545 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 509170003546 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 509170003547 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170003548 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 509170003549 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 509170003550 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 509170003551 purine monophosphate binding site [chemical binding]; other site 509170003552 dimer interface [polypeptide binding]; other site 509170003553 putative catalytic residues [active] 509170003554 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509170003555 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509170003556 Helix-turn-helix domains; Region: HTH; cl00088 509170003557 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 509170003558 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 509170003559 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 509170003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003561 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003562 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 509170003563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003564 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 509170003565 Transposase domain (DUF772); Region: DUF772; cl15789 509170003566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003567 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of nitrite reductase, large subunit, nucleotide-and Fe/S-cluster binding (partial) 509170003568 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 509170003569 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 509170003570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170003571 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 509170003572 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 509170003573 [4Fe-4S] binding site [ion binding]; other site 509170003574 molybdopterin cofactor binding site; other site 509170003575 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 509170003576 molybdopterin cofactor binding site; other site 509170003577 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 509170003578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 509170003579 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 509170003580 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 509170003581 GTP binding site; other site 509170003582 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003584 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 509170003585 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 509170003586 dimer interface [polypeptide binding]; other site 509170003587 active site 509170003588 Schiff base residues; other site 509170003589 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 509170003590 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170003591 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Beta-ketoadipyl CoA thiolase (part 1) 509170003592 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Beta-ketoadipyl CoA thiolase (part 2) 509170003593 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170003594 EamA-like transporter family; Region: EamA; cl01037 509170003595 EamA-like transporter family; Region: EamA; cl01037 509170003596 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170003597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003598 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003599 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003600 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glutathione S-transferase (partial) 509170003601 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of short chain dehydrogenase (partial) 509170003602 Transposase domain (DUF772); Region: DUF772; cl15789 509170003603 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003604 Chorismate mutase type II; Region: CM_2; cl00693 509170003605 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 509170003606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170003607 putative DNA binding site [nucleotide binding]; other site 509170003608 putative Zn2+ binding site [ion binding]; other site 509170003609 Helix-turn-helix domains; Region: HTH; cl00088 509170003610 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003613 Helix-turn-helix domains; Region: HTH; cl00088 509170003614 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 509170003615 putative dimerization interface [polypeptide binding]; other site 509170003616 LrgA family; Region: LrgA; cl00608 509170003617 LrgB-like family; Region: LrgB; cl00596 509170003618 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170003619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170003620 DNA-binding site [nucleotide binding]; DNA binding site 509170003621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170003622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170003623 homodimer interface [polypeptide binding]; other site 509170003624 catalytic residue [active] 509170003625 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (part 1) 509170003626 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (part 2) 509170003627 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 509170003628 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170003629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003630 putative substrate translocation pore; other site 509170003631 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003632 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003633 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides (partial) 509170003634 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 509170003635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170003636 TPR motif; other site 509170003637 binding surface 509170003638 serine O-acetyltransferase; Region: cysE; TIGR01172 509170003639 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 509170003640 trimer interface [polypeptide binding]; other site 509170003641 active site 509170003642 substrate binding site [chemical binding]; other site 509170003643 CoA binding site [chemical binding]; other site 509170003644 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 509170003645 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509170003646 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 509170003647 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 509170003648 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 509170003649 generic binding surface II; other site 509170003650 generic binding surface I; other site 509170003651 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003652 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003653 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003654 Predicted transcriptional regulator [Transcription]; Region: COG2378 509170003655 WYL domain; Region: WYL; cl14852 509170003656 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003657 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003659 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of alanine racemase 1, biosynthetic (partial) 509170003660 replicative DNA helicase; Region: DnaB; TIGR00665 509170003661 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 509170003662 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 509170003663 Walker A motif; other site 509170003664 ATP binding site [chemical binding]; other site 509170003665 Walker B motif; other site 509170003666 DNA binding loops [nucleotide binding] 509170003667 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 509170003668 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 509170003669 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 509170003670 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 509170003671 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 509170003672 UbiA prenyltransferase family; Region: UbiA; cl00337 509170003673 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 509170003674 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 509170003675 Subunit I/III interface [polypeptide binding]; other site 509170003676 Subunit III/IV interface [polypeptide binding]; other site 509170003677 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 509170003678 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 509170003679 D-pathway; other site 509170003680 Putative ubiquinol binding site [chemical binding]; other site 509170003681 Low-spin heme (heme b) binding site [chemical binding]; other site 509170003682 Putative water exit pathway; other site 509170003683 Binuclear center (heme o3/CuB) [ion binding]; other site 509170003684 K-pathway; other site 509170003685 Putative proton exit pathway; other site 509170003686 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 509170003687 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 509170003688 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 509170003689 RDD family; Region: RDD; cl00746 509170003690 phosphoenolpyruvate synthase; Validated; Region: PRK06464 509170003691 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509170003692 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 509170003693 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 509170003694 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 509170003695 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003696 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003697 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (part 2) 509170003698 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family)(part 1) 509170003699 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 509170003700 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 509170003701 potential catalytic triad [active] 509170003702 conserved cys residue [active] 509170003703 peptide chain release factor 1; Validated; Region: prfA; PRK00591 509170003704 RF-1 domain; Region: RF-1; cl02875 509170003705 RF-1 domain; Region: RF-1; cl02875 509170003706 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 509170003707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170003708 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170003709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 509170003710 SurA N-terminal domain; Region: SurA_N_3; cl07813 509170003711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170003712 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509170003713 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 509170003714 NAD binding site [chemical binding]; other site 509170003715 homotetramer interface [polypeptide binding]; other site 509170003716 homodimer interface [polypeptide binding]; other site 509170003717 active site 509170003718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170003719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170003720 active site 509170003721 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 509170003722 AMP-binding enzyme; Region: AMP-binding; cl15778 509170003723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003724 Flavin Reductases; Region: FlaRed; cl00801 509170003725 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 509170003726 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 509170003727 ATP binding site [chemical binding]; other site 509170003728 substrate interface [chemical binding]; other site 509170003729 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170003730 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 509170003731 homooctamer interface [polypeptide binding]; other site 509170003732 active site 509170003733 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 509170003734 catalytic center binding site [active] 509170003735 ATP binding site [chemical binding]; other site 509170003736 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 509170003737 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 509170003738 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 509170003739 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170003740 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170003741 K+-transporting ATPase, c chain; Region: KdpC; cl00944 509170003742 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 509170003743 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 509170003744 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 509170003745 Ligand Binding Site [chemical binding]; other site 509170003746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170003747 dimer interface [polypeptide binding]; other site 509170003748 phosphorylation site [posttranslational modification] 509170003749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170003750 ATP binding site [chemical binding]; other site 509170003751 Mg2+ binding site [ion binding]; other site 509170003752 G-X-G motif; other site 509170003753 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 509170003754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170003755 active site 509170003756 phosphorylation site [posttranslational modification] 509170003757 intermolecular recognition site; other site 509170003758 dimerization interface [polypeptide binding]; other site 509170003759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170003760 DNA binding site [nucleotide binding] 509170003761 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509170003762 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003764 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 509170003765 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 509170003766 diiron binding motif [ion binding]; other site 509170003767 lysophospholipid transporter LplT; Provisional; Region: PRK11195 509170003768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170003769 putative substrate translocation pore; other site 509170003770 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 509170003771 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003772 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 509170003773 Surface antigen; Region: Bac_surface_Ag; cl03097 509170003774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 509170003775 Family of unknown function (DUF490); Region: DUF490; pfam04357 509170003776 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 509170003777 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 509170003778 substrate binding site [chemical binding]; other site 509170003779 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 509170003780 substrate binding site [chemical binding]; other site 509170003781 ligand binding site [chemical binding]; other site 509170003782 Transposase domain (DUF772); Region: DUF772; cl15789 509170003783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003784 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003785 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003786 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170003787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170003788 Helix-turn-helix domains; Region: HTH; cl00088 509170003789 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 509170003790 putative dimerization interface [polypeptide binding]; other site 509170003791 Protein of unknown function (DUF441); Region: DUF441; cl01041 509170003792 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509170003793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 509170003794 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 509170003795 active site 509170003796 uracil binding [chemical binding]; other site 509170003797 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 509170003798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170003799 Coenzyme A binding pocket [chemical binding]; other site 509170003800 RelB antitoxin; Region: RelB; cl01171 509170003801 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509170003802 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 509170003803 probable active site [active] 509170003804 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 509170003805 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 509170003806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170003807 ATP binding site [chemical binding]; other site 509170003808 Mg2+ binding site [ion binding]; other site 509170003809 G-X-G motif; other site 509170003810 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 509170003811 ATP binding site [chemical binding]; other site 509170003812 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 509170003813 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 509170003814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170003815 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 509170003816 Sm1 motif; other site 509170003817 intra - hexamer interaction site; other site 509170003818 inter - hexamer interaction site [polypeptide binding]; other site 509170003819 nucleotide binding pocket [chemical binding]; other site 509170003820 Sm2 motif; other site 509170003821 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of integral membrane protein (partial) 509170003822 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003823 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003824 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 509170003825 putative active site [active] 509170003826 putative metal binding site [ion binding]; other site 509170003827 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 509170003828 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 509170003829 substrate binding site [chemical binding]; other site 509170003830 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 509170003831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170003832 active site 509170003833 HIGH motif; other site 509170003834 nucleotide binding site [chemical binding]; other site 509170003835 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 509170003836 KMSKS motif; other site 509170003837 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 509170003838 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003839 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003840 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 509170003841 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509170003842 catalytic triad [active] 509170003843 Evidence 7 : Gene remnant; PubMedId : 2197274; Product type e : enzyme; fragment of ethanolamine ammonia-lyase light chain (Ethanolamine ammonia-lyase small subunit) (EutC) (part 2) 509170003844 Evidence 7 : Gene remnant; PubMedId : 2197274; Product type e : enzyme; fragment of ethanolamine ammonia-lyase light chain (Ethanolamine ammonia-lyase small subunit) (EutC) (part 1) 509170003845 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 509170003846 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 509170003847 ethanolamine permease; Region: 2A0305; TIGR00908 509170003848 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 509170003849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170003850 NAD(P) binding site [chemical binding]; other site 509170003851 catalytic residues [active] 509170003852 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 509170003853 Helix-turn-helix domains; Region: HTH; cl00088 509170003854 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509170003855 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170003856 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 509170003857 putative alcohol dehydrogenase; Provisional; Region: PRK09860 509170003858 dimer interface [polypeptide binding]; other site 509170003859 active site 509170003860 metal binding site [ion binding]; metal-binding site 509170003861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003862 PIF1-like helicase; Region: PIF1; pfam05970 509170003863 Walker A motif; other site 509170003864 ATP binding site [chemical binding]; other site 509170003865 Walker B motif; other site 509170003866 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 509170003867 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 509170003868 putative substrate binding pocket [chemical binding]; other site 509170003869 trimer interface [polypeptide binding]; other site 509170003870 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 509170003871 substrate binding site [chemical binding]; other site 509170003872 multimerization interface [polypeptide binding]; other site 509170003873 ATP binding site [chemical binding]; other site 509170003874 Transposase domain (DUF772); Region: DUF772; cl15789 509170003875 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003876 aminopeptidase N; Provisional; Region: pepN; PRK14015 509170003877 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 509170003878 active site 509170003879 Zn binding site [ion binding]; other site 509170003880 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003881 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003882 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 509170003883 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 509170003884 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170003885 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003886 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170003887 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 509170003888 trimer interface [polypeptide binding]; other site 509170003889 putative active site [active] 509170003890 dimer interface [polypeptide binding]; other site 509170003891 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 509170003892 MPT binding site; other site 509170003893 trimer interface [polypeptide binding]; other site 509170003894 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 509170003895 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 509170003896 dimer interface [polypeptide binding]; other site 509170003897 putative functional site; other site 509170003898 putative MPT binding site; other site 509170003899 Helix-turn-helix domains; Region: HTH; cl00088 509170003900 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170003901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170003902 DNA-binding site [nucleotide binding]; DNA binding site 509170003903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170003904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170003905 homodimer interface [polypeptide binding]; other site 509170003906 catalytic residue [active] 509170003907 EamA-like transporter family; Region: EamA; cl01037 509170003908 EamA-like transporter family; Region: EamA; cl01037 509170003909 DsrC like protein; Region: DsrC; cl01101 509170003910 DsrE/DsrF-like family; Region: DrsE; cl00672 509170003911 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of UDP-galactose 4-epimerase (GalE-like) (partial) 509170003912 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003913 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003914 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003915 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170003916 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 509170003917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003918 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 509170003919 homotrimer interaction site [polypeptide binding]; other site 509170003920 zinc binding site [ion binding]; other site 509170003921 CDP-binding sites; other site 509170003922 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170003923 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170003924 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170003925 ornithine carbamoyltransferase; Provisional; Region: PRK00779 509170003926 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509170003927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170003928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170003929 Helix-turn-helix domains; Region: HTH; cl00088 509170003930 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 509170003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170003932 active site 509170003933 phosphorylation site [posttranslational modification] 509170003934 intermolecular recognition site; other site 509170003935 dimerization interface [polypeptide binding]; other site 509170003936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170003937 Walker A motif; other site 509170003938 ATP binding site [chemical binding]; other site 509170003939 Walker B motif; other site 509170003940 arginine finger; other site 509170003941 Helix-turn-helix domains; Region: HTH; cl00088 509170003942 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 509170003943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509170003944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170003945 dimer interface [polypeptide binding]; other site 509170003946 phosphorylation site [posttranslational modification] 509170003947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170003948 ATP binding site [chemical binding]; other site 509170003949 Mg2+ binding site [ion binding]; other site 509170003950 G-X-G motif; other site 509170003951 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 509170003952 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509170003953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170003954 FeS/SAM binding site; other site 509170003955 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 509170003956 putative nucleotide binding site [chemical binding]; other site 509170003957 uridine monophosphate binding site [chemical binding]; other site 509170003958 homohexameric interface [polypeptide binding]; other site 509170003959 ribosome recycling factor; Reviewed; Region: frr; PRK00083 509170003960 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 509170003961 hinge region; other site 509170003962 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 509170003963 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 509170003964 catalytic residue [active] 509170003965 putative FPP diphosphate binding site; other site 509170003966 putative FPP binding hydrophobic cleft; other site 509170003967 dimer interface [polypeptide binding]; other site 509170003968 putative IPP diphosphate binding site; other site 509170003969 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 509170003970 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 509170003971 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 509170003972 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 509170003973 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 509170003974 zinc metallopeptidase RseP; Provisional; Region: PRK10779 509170003975 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509170003976 active site 509170003977 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 509170003978 protein binding site [polypeptide binding]; other site 509170003979 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 509170003980 protein binding site [polypeptide binding]; other site 509170003981 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509170003982 putative substrate binding region [chemical binding]; other site 509170003983 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 509170003984 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003985 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003986 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003987 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170003988 Surface antigen; Region: Bac_surface_Ag; cl03097 509170003989 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 509170003990 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 509170003991 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 509170003992 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 509170003993 trimer interface [polypeptide binding]; other site 509170003994 active site 509170003995 UDP-GlcNAc binding site [chemical binding]; other site 509170003996 lipid binding site [chemical binding]; lipid-binding site 509170003997 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 509170003998 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 509170003999 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 509170004000 active site 509170004001 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 509170004002 RecX family; Region: RecX; cl00936 509170004003 recombinase A; Provisional; Region: recA; PRK09354 509170004004 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 509170004005 hexamer interface [polypeptide binding]; other site 509170004006 Walker A motif; other site 509170004007 ATP binding site [chemical binding]; other site 509170004008 Walker B motif; other site 509170004009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170004010 RNA binding surface [nucleotide binding]; other site 509170004011 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of haloacid dehalogenase-like hydrolase (part 2) 509170004012 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of haloacid dehalogenase-like hydrolase (part 1) 509170004013 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 509170004014 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 509170004015 Transposase domain (DUF772); Region: DUF772; cl15789 509170004016 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 509170004018 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170004019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170004020 putative DNA binding site [nucleotide binding]; other site 509170004021 putative Zn2+ binding site [ion binding]; other site 509170004022 Helix-turn-helix domains; Region: HTH; cl00088 509170004023 kynureninase; Region: kynureninase; TIGR01814 509170004024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170004025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170004026 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170004027 catalytic residue [active] 509170004028 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 509170004029 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004030 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004032 Cupin superfamily protein; Region: Cupin_4; pfam08007 509170004033 Maf-like protein; Region: Maf; pfam02545 509170004034 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509170004035 active site 509170004036 dimer interface [polypeptide binding]; other site 509170004037 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 509170004038 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 509170004039 Phosphoglycerate kinase; Region: PGK; pfam00162 509170004040 substrate binding site [chemical binding]; other site 509170004041 hinge regions; other site 509170004042 ADP binding site [chemical binding]; other site 509170004043 catalytic site [active] 509170004044 hypothetical protein; Provisional; Region: PRK08185 509170004045 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 509170004046 intersubunit interface [polypeptide binding]; other site 509170004047 active site 509170004048 zinc binding site [ion binding]; other site 509170004049 Na+ binding site [ion binding]; other site 509170004050 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 509170004051 SurA N-terminal domain; Region: SurA_N_3; cl07813 509170004052 PPIC-type PPIASE domain; Region: Rotamase; cl08278 509170004053 PPIC-type PPIASE domain; Region: Rotamase; cl08278 509170004054 OstA-like protein; Region: OstA; cl00844 509170004055 Organic solvent tolerance protein; Region: OstA_C; pfam04453 509170004056 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170004057 Phosphotransferase enzyme family; Region: APH; pfam01636 509170004058 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 509170004059 Substrate binding site; other site 509170004060 metal-binding site 509170004061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170004062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509170004063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170004064 P-loop; other site 509170004065 Magnesium ion binding site [ion binding]; other site 509170004066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 509170004067 Magnesium ion binding site [ion binding]; other site 509170004068 ParB-like partition proteins; Region: parB_part; TIGR00180 509170004069 ParB-like nuclease domain; Region: ParBc; cl02129 509170004070 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509170004071 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of biopolymer transport protein (EXBD-like) 509170004072 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 509170004073 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509170004074 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 509170004075 Walker A/P-loop; other site 509170004076 ATP binding site [chemical binding]; other site 509170004077 Q-loop/lid; other site 509170004078 ABC transporter signature motif; other site 509170004079 Walker B; other site 509170004080 D-loop; other site 509170004081 H-loop/switch region; other site 509170004082 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 509170004083 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 509170004084 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 509170004085 Ligand binding site; other site 509170004086 oligomer interface; other site 509170004087 DNA polymerase III subunit delta'; Validated; Region: PRK05707 509170004088 PilZ domain; Region: PilZ; cl01260 509170004089 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509170004090 active site 509170004091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170004092 Helix-turn-helix domains; Region: HTH; cl00088 509170004093 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 509170004094 general secretion pathway protein J; Region: gspJ; TIGR01711 509170004095 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 509170004096 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 509170004097 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 509170004098 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509170004099 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 509170004100 ligand binding site [chemical binding]; other site 509170004101 active site 509170004102 UGI interface [polypeptide binding]; other site 509170004103 catalytic site [active] 509170004104 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 509170004105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170004106 substrate binding site [chemical binding]; other site 509170004107 oxyanion hole (OAH) forming residues; other site 509170004108 trimer interface [polypeptide binding]; other site 509170004109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 509170004110 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509170004111 nucleoside/Zn binding site; other site 509170004112 dimer interface [polypeptide binding]; other site 509170004113 catalytic motif [active] 509170004114 cytidylate kinase; Provisional; Region: cmk; PRK00023 509170004115 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 509170004116 CMP-binding site; other site 509170004117 The sites determining sugar specificity; other site 509170004118 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 509170004119 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 509170004120 RNA binding site [nucleotide binding]; other site 509170004121 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 509170004122 RNA binding site [nucleotide binding]; other site 509170004123 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 509170004124 RNA binding site [nucleotide binding]; other site 509170004125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509170004126 RNA binding site [nucleotide binding]; other site 509170004127 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 509170004128 RNA binding site [nucleotide binding]; other site 509170004129 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 509170004130 RNA binding site [nucleotide binding]; other site 509170004131 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170004132 IHF dimer interface [polypeptide binding]; other site 509170004133 IHF - DNA interface [nucleotide binding]; other site 509170004134 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 509170004135 active site 509170004136 dimer interface [polypeptide binding]; other site 509170004137 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 509170004138 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004140 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of flavin-binding monooxygenase (partial) 509170004141 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170004142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004144 Predicted ATPase [General function prediction only]; Region: COG1485 509170004145 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170004146 DNA binding site [nucleotide binding] 509170004147 Int/Topo IB signature motif; other site 509170004148 active site 509170004149 BRO family, N-terminal domain; Region: Bro-N; cl10591 509170004150 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 509170004151 ERF superfamily; Region: ERF; pfam04404 509170004152 replicative DNA helicase; Provisional; Region: PRK08840 509170004153 hypothetical protein; Provisional; Region: PRK09946 509170004154 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 509170004155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170004156 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170004157 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 509170004158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170004159 non-specific DNA binding site [nucleotide binding]; other site 509170004160 salt bridge; other site 509170004161 sequence-specific DNA binding site [nucleotide binding]; other site 509170004162 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170004163 Catalytic site [active] 509170004164 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 509170004165 Surface antigen [General function prediction only]; Region: COG3942 509170004166 Terminase small subunit; Region: Terminase_2; cl01513 509170004167 Phage terminase large subunit; Region: Terminase_3; cl12054 509170004168 Terminase-like family; Region: Terminase_6; pfam03237 509170004169 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 509170004170 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170004171 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 509170004172 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004173 hypothetical protein; Provisional; Region: PRK10040 509170004174 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 509170004175 Arc-like DNA binding domain; Region: Arc; pfam03869 509170004176 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 509170004177 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 509170004178 tape measure domain; Region: tape_meas_nterm; TIGR02675 509170004179 Phage-related minor tail protein [Function unknown]; Region: COG5281 509170004180 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170004181 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170004182 catalytic residue [active] 509170004183 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 509170004184 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 509170004185 catalytic residues [active] 509170004186 PAAR motif; Region: PAAR_motif; cl15808 509170004187 Transposase domain (DUF772); Region: DUF772; cl15789 509170004188 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004189 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 509170004190 active site 509170004191 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509170004192 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509170004193 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509170004194 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170004195 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 509170004196 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170004197 N-terminal plug; other site 509170004198 ligand-binding site [chemical binding]; other site 509170004199 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 509170004200 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509170004201 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 509170004202 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509170004203 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 509170004204 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 509170004205 active site 509170004206 Zn binding site [ion binding]; other site 509170004207 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 509170004208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170004209 dimer interface [polypeptide binding]; other site 509170004210 conserved gate region; other site 509170004211 putative PBP binding loops; other site 509170004212 ABC-ATPase subunit interface; other site 509170004213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170004214 dimer interface [polypeptide binding]; other site 509170004215 conserved gate region; other site 509170004216 putative PBP binding loops; other site 509170004217 ABC-ATPase subunit interface; other site 509170004218 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 509170004219 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509170004220 Walker A/P-loop; other site 509170004221 ATP binding site [chemical binding]; other site 509170004222 Q-loop/lid; other site 509170004223 ABC transporter signature motif; other site 509170004224 Walker B; other site 509170004225 D-loop; other site 509170004226 H-loop/switch region; other site 509170004227 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509170004228 Walker A/P-loop; other site 509170004229 ATP binding site [chemical binding]; other site 509170004230 Q-loop/lid; other site 509170004231 ABC transporter signature motif; other site 509170004232 Walker B; other site 509170004233 D-loop; other site 509170004234 H-loop/switch region; other site 509170004235 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 509170004236 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 509170004237 active site 509170004238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170004239 catalytic core [active] 509170004240 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 509170004241 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 509170004242 NAD binding site [chemical binding]; other site 509170004243 active site 509170004244 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 509170004245 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509170004246 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004248 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004249 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004250 Transposase domain (DUF772); Region: DUF772; cl15789 509170004251 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004252 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004253 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004254 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004255 transcription-repair coupling factor; Provisional; Region: PRK10689 509170004256 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 509170004257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170004258 ATP binding site [chemical binding]; other site 509170004259 putative Mg++ binding site [ion binding]; other site 509170004260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509170004261 nucleotide binding region [chemical binding]; other site 509170004262 ATP-binding site [chemical binding]; other site 509170004263 TRCF domain; Region: TRCF; cl04088 509170004264 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 509170004265 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004267 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004268 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of adenylate or guanylate cyclase (partial) 509170004269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170004270 catalytic loop [active] 509170004271 iron binding site [ion binding]; other site 509170004272 chaperone protein HscA; Provisional; Region: hscA; PRK05183 509170004273 co-chaperone HscB; Provisional; Region: hscB; PRK05014 509170004274 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509170004275 HSP70 interaction site [polypeptide binding]; other site 509170004276 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 509170004277 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 509170004278 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 509170004279 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 509170004280 trimerization site [polypeptide binding]; other site 509170004281 active site 509170004282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170004283 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 509170004284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170004285 catalytic residue [active] 509170004286 Helix-turn-helix domains; Region: HTH; cl00088 509170004287 Rrf2 family protein; Region: rrf2_super; TIGR00738 509170004288 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 509170004289 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170004290 IHF dimer interface [polypeptide binding]; other site 509170004291 IHF - DNA interface [nucleotide binding]; other site 509170004292 periplasmic folding chaperone; Provisional; Region: PRK10788 509170004293 SurA N-terminal domain; Region: SurA_N_3; cl07813 509170004294 PPIC-type PPIASE domain; Region: Rotamase; cl08278 509170004295 Cupin domain; Region: Cupin_2; cl09118 509170004296 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004298 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 509170004299 Fatty acid desaturase; Region: FA_desaturase; pfam00487 509170004300 Di-iron ligands [ion binding]; other site 509170004301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170004302 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170004303 active site 509170004304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170004305 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170004306 active site 509170004307 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170004308 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004309 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004310 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 509170004311 IucA / IucC family; Region: IucA_IucC; pfam04183 509170004312 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 509170004313 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004315 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 509170004316 Mor transcription activator family; Region: Mor; cl02360 509170004317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 509170004318 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 509170004319 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 509170004320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170004321 motif II; other site 509170004322 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 509170004323 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 509170004324 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 509170004325 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 509170004326 homotrimer interface [polypeptide binding]; other site 509170004327 Walker A motif; other site 509170004328 GTP binding site [chemical binding]; other site 509170004329 Walker B motif; other site 509170004330 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) (CobT) (part 1) 509170004331 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase) (CobT) (part 2) 509170004332 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509170004333 catalytic core [active] 509170004334 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 509170004335 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of cobalamin 5'-phosphate synthase (CobS) (part 1) 509170004336 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of cobalamin 5'-phosphate synthase (CobS) (part 2) 509170004337 NeuB family; Region: NeuB; cl00496 509170004338 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004339 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170004340 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509170004341 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004343 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 509170004344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170004345 Helix-turn-helix domains; Region: HTH; cl00088 509170004346 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 509170004347 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 1) 509170004348 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 2) 509170004349 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane fusion protein (part 3) 509170004350 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509170004351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170004352 Walker A/P-loop; other site 509170004353 ATP binding site [chemical binding]; other site 509170004354 Q-loop/lid; other site 509170004355 ABC transporter signature motif; other site 509170004356 Walker B; other site 509170004357 D-loop; other site 509170004358 H-loop/switch region; other site 509170004359 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 509170004360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170004361 Walker A/P-loop; other site 509170004362 ATP binding site [chemical binding]; other site 509170004363 Q-loop/lid; other site 509170004364 ABC transporter signature motif; other site 509170004365 Walker B; other site 509170004366 D-loop; other site 509170004367 H-loop/switch region; other site 509170004368 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509170004369 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509170004370 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 509170004371 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170004372 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 509170004373 eyelet of channel; other site 509170004374 trimer interface [polypeptide binding]; other site 509170004375 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 509170004376 HIT family signature motif; other site 509170004377 catalytic residue [active] 509170004378 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004380 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170004381 Transposase domain (DUF772); Region: DUF772; cl15789 509170004382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004383 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004384 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004385 phosphoethanolamine N-methyltransferase; Region: PLN02336 509170004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170004387 S-adenosylmethionine binding site [chemical binding]; other site 509170004388 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 509170004389 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 509170004390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509170004391 homodimer interface [polypeptide binding]; other site 509170004392 substrate-cofactor binding pocket; other site 509170004393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004394 catalytic residue [active] 509170004395 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 509170004396 recombination protein RecR; Reviewed; Region: recR; PRK00076 509170004397 RecR protein; Region: RecR; pfam02132 509170004398 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 509170004399 putative active site [active] 509170004400 putative metal-binding site [ion binding]; other site 509170004401 tetramer interface [polypeptide binding]; other site 509170004402 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 509170004403 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 509170004404 putative active site [active] 509170004405 catalytic site [active] 509170004406 putative substrate binding site [chemical binding]; other site 509170004407 HRDC domain; Region: HRDC; cl02578 509170004408 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004410 Transposase domain (DUF772); Region: DUF772; cl15789 509170004411 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004412 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004413 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004414 YcgL domain; Region: YcgL; cl01189 509170004415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004416 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509170004417 Walker A motif; other site 509170004418 ATP binding site [chemical binding]; other site 509170004419 Walker B motif; other site 509170004420 arginine finger; other site 509170004421 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 509170004422 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509170004423 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 509170004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004425 catalytic residue [active] 509170004426 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004428 HemK family putative methylases; Region: hemK_fam; TIGR00536 509170004429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170004430 S-adenosylmethionine binding site [chemical binding]; other site 509170004431 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 509170004432 Tetramer interface [polypeptide binding]; other site 509170004433 active site 509170004434 FMN-binding site [chemical binding]; other site 509170004435 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004437 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (partial) 509170004438 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 509170004439 acetoin reductases; Region: 23BDH; TIGR02415 509170004440 NAD binding site [chemical binding]; other site 509170004441 homotetramer interface [polypeptide binding]; other site 509170004442 homodimer interface [polypeptide binding]; other site 509170004443 active site 509170004444 substrate binding site [chemical binding]; other site 509170004445 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509170004446 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 509170004447 putative NAD(P) binding site [chemical binding]; other site 509170004448 catalytic Zn binding site [ion binding]; other site 509170004449 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 509170004450 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 509170004451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004452 Walker A motif; other site 509170004453 ATP binding site [chemical binding]; other site 509170004454 Walker B motif; other site 509170004455 arginine finger; other site 509170004456 Helix-turn-helix domains; Region: HTH; cl00088 509170004457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170004458 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 509170004459 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 509170004460 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509170004461 homoserine dehydrogenase; Validated; Region: PRK06813 509170004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170004463 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509170004464 EamA-like transporter family; Region: EamA; cl01037 509170004465 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170004466 EamA-like transporter family; Region: EamA; cl01037 509170004467 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004469 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004470 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004471 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004472 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170004474 non-specific DNA binding site [nucleotide binding]; other site 509170004475 salt bridge; other site 509170004476 sequence-specific DNA binding site [nucleotide binding]; other site 509170004477 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004478 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004479 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of Outer membrane protein (partial) 509170004480 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) (part 1) 509170004481 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) (part 2) 509170004482 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 509170004483 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 509170004484 intersubunit interface [polypeptide binding]; other site 509170004485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 509170004486 ABC-ATPase subunit interface; other site 509170004487 dimer interface [polypeptide binding]; other site 509170004488 putative PBP binding regions; other site 509170004489 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509170004490 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 509170004491 Walker A/P-loop; other site 509170004492 ATP binding site [chemical binding]; other site 509170004493 Q-loop/lid; other site 509170004494 ABC transporter signature motif; other site 509170004495 Walker B; other site 509170004496 D-loop; other site 509170004497 H-loop/switch region; other site 509170004498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170004499 Coenzyme A binding pocket [chemical binding]; other site 509170004500 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fragment of Transcriptional regulator (AraC family) (part 2) 509170004501 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004502 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004503 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fragment of Transcriptional regulator (AraC family) (part 1) 509170004504 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509170004505 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170004506 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 509170004507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170004508 active site 509170004509 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 509170004510 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 509170004511 active site 509170004512 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 509170004513 nudix motif; other site 509170004514 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 509170004515 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 509170004516 FAD binding site [chemical binding]; other site 509170004517 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 509170004518 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004519 Transposase domain (DUF772); Region: DUF772; cl15789 509170004520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004521 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (partial) 509170004522 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 509170004523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170004524 catalytic loop [active] 509170004525 iron binding site [ion binding]; other site 509170004526 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 509170004527 FAD binding pocket [chemical binding]; other site 509170004528 FAD binding motif [chemical binding]; other site 509170004529 phosphate binding motif [ion binding]; other site 509170004530 beta-alpha-beta structure motif; other site 509170004531 NAD binding pocket [chemical binding]; other site 509170004532 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 509170004533 inter-subunit interface; other site 509170004534 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 509170004535 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509170004536 [2Fe-2S] cluster binding site [ion binding]; other site 509170004537 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 509170004538 putative alpha subunit interface [polypeptide binding]; other site 509170004539 putative active site [active] 509170004540 putative substrate binding site [chemical binding]; other site 509170004541 Fe binding site [ion binding]; other site 509170004542 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of repressor of the modABC operon for molybdenum transport (ModE) (part 1) 509170004543 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of repressor of the modABC operon for molybdenum transport (ModE) (part 2) 509170004544 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004546 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of Ferric uptake regulator (partial) 509170004547 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 509170004548 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 509170004549 putative active site [active] 509170004550 putative metal binding site [ion binding]; other site 509170004551 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 509170004552 polyphosphate kinase; Provisional; Region: PRK05443 509170004553 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 509170004554 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 509170004555 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509170004556 putative active site [active] 509170004557 catalytic site [active] 509170004558 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 509170004559 putative domain interface [polypeptide binding]; other site 509170004560 putative active site [active] 509170004561 catalytic site [active] 509170004562 PqqA family; Region: PqqA; cl15372 509170004563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170004564 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 509170004565 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 509170004566 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 509170004567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170004568 FeS/SAM binding site; other site 509170004569 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 509170004570 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 509170004571 active site 509170004572 dimer interface [polypeptide binding]; other site 509170004573 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170004576 Protein of unknown function (DUF2523); Region: DUF2523; cl10291 509170004577 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 509170004578 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004580 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of Transcriptional regulator (GntR family) (partial) 509170004581 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 509170004582 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170004583 Helix-turn-helix domains; Region: HTH; cl00088 509170004584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170004585 dimerization interface [polypeptide binding]; other site 509170004586 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 509170004587 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 509170004588 octamer interface [polypeptide binding]; other site 509170004589 active site 509170004590 Muconolactone delta-isomerase; Region: MIase; cl01992 509170004591 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 509170004592 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 509170004593 dimer interface [polypeptide binding]; other site 509170004594 active site 509170004595 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509170004596 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509170004597 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 509170004598 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170004599 dimer interface [polypeptide binding]; other site 509170004600 active site 509170004601 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170004602 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170004603 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004604 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004606 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acyl-CoA dehydrogenase (partial) 509170004607 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170004608 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 509170004609 Helix-turn-helix domains; Region: HTH; cl00088 509170004610 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170004611 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004612 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004613 Predicted transporter component [General function prediction only]; Region: COG2391 509170004614 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 509170004615 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 509170004616 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 509170004617 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 509170004618 Trp docking motif [polypeptide binding]; other site 509170004619 putative active site [active] 509170004620 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 509170004621 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 509170004622 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 509170004623 Evidence 7 : Gene remnant; PubMedId : 7592351; Product type e : enzyme; fragment of catabolic 3-dehydroquinate dehydratase (3-dehydroquinase) (QuiB) (part 2) 509170004624 Evidence 7 : Gene remnant; PubMedId : 7592351; Product type e : enzyme; fragment of catabolic 3-dehydroquinate dehydratase (3-dehydroquinase)(QuiB) (part 1) 509170004625 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 509170004626 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 509170004627 heterodimer interface [polypeptide binding]; other site 509170004628 active site 509170004629 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 509170004630 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 509170004631 active site 509170004632 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 509170004633 benzoate transport; Region: 2A0115; TIGR00895 509170004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170004635 putative substrate translocation pore; other site 509170004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170004637 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170004638 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 509170004639 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 509170004640 tetramer interface [polypeptide binding]; other site 509170004641 active site 509170004642 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 509170004643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170004644 dimer interface [polypeptide binding]; other site 509170004645 active site 509170004646 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509170004647 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509170004648 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 509170004649 substrate binding site; other site 509170004650 dimer interface; other site 509170004651 Septum formation initiator; Region: DivIC; cl11433 509170004652 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004654 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004655 Transposase domain (DUF772); Region: DUF772; cl15789 509170004656 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004657 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004658 enolase; Provisional; Region: eno; PRK00077 509170004659 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 509170004660 dimer interface [polypeptide binding]; other site 509170004661 metal binding site [ion binding]; metal-binding site 509170004662 substrate binding pocket [chemical binding]; other site 509170004663 NeuB family; Region: NeuB; cl00496 509170004664 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004665 CTP synthetase; Validated; Region: pyrG; PRK05380 509170004666 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 509170004667 Catalytic site [active] 509170004668 active site 509170004669 UTP binding site [chemical binding]; other site 509170004670 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 509170004671 active site 509170004672 putative oxyanion hole; other site 509170004673 catalytic triad [active] 509170004674 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170004675 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170004676 hydrolase; Region: PLN02511 509170004677 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 509170004678 active site 509170004679 catalytic triad [active] 509170004680 oxyanion hole [active] 509170004681 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 509170004682 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 4) 509170004683 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 3) 509170004684 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 2) 509170004685 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of 2,4-dienoyl-CoA reductase (part 1) 509170004686 Helix-turn-helix domains; Region: HTH; cl00088 509170004687 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 509170004688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170004689 NeuB family; Region: NeuB; cl00496 509170004690 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509170004691 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 509170004692 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 509170004693 Clp amino terminal domain; Region: Clp_N; pfam02861 509170004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004695 Walker A motif; other site 509170004696 ATP binding site [chemical binding]; other site 509170004697 Walker B motif; other site 509170004698 arginine finger; other site 509170004699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170004700 Walker A motif; other site 509170004701 ATP binding site [chemical binding]; other site 509170004702 Walker B motif; other site 509170004703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 509170004704 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 509170004705 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945 509170004706 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 509170004707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170004708 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 509170004709 Protein of unknown function DUF45; Region: DUF45; cl00636 509170004710 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 509170004711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170004712 active site 509170004713 dimer interface [polypeptide binding]; other site 509170004714 threonine dehydratase; Reviewed; Region: PRK09224 509170004715 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 509170004716 tetramer interface [polypeptide binding]; other site 509170004717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004718 catalytic residue [active] 509170004719 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 509170004720 putative Ile/Val binding site [chemical binding]; other site 509170004721 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 509170004722 putative Ile/Val binding site [chemical binding]; other site 509170004723 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 509170004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170004725 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 509170004726 Cation transport protein; Region: TrkH; cl10514 509170004727 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phospholipase A1 precursor (PldA) (part 2) 509170004728 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phospholipase A1 precursor (PldA) (part 1) 509170004729 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 509170004730 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509170004731 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509170004732 Peptidase M16C associated; Region: M16C_assoc; pfam08367 509170004733 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferrisiderophore receptor protein, TonB dependent (part 2) 509170004734 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferrisiderophore receptor protein, TonB dependent (part 1) 509170004735 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 509170004736 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 509170004737 substrate binding site [chemical binding]; other site 509170004738 ATP binding site [chemical binding]; other site 509170004739 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 509170004740 iron-sulfur cluster [ion binding]; other site 509170004741 [2Fe-2S] cluster binding site [ion binding]; other site 509170004742 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 509170004743 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004744 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004745 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 509170004746 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 509170004747 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 509170004748 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 509170004749 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 509170004750 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 509170004751 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 2) 509170004752 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004753 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004754 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of acetyltransferase (part 1) 509170004755 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 509170004756 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004757 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004758 Transposase domain (DUF772); Region: DUF772; cl15789 509170004759 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004760 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 509170004761 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 509170004762 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509170004763 P loop; other site 509170004764 GTP binding site [chemical binding]; other site 509170004765 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 509170004766 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 509170004767 FOG: CBS domain [General function prediction only]; Region: COG0517 509170004768 acetylornithine aminotransferase; Provisional; Region: PRK02627 509170004769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170004770 inhibitor-cofactor binding pocket; inhibition site 509170004771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004772 catalytic residue [active] 509170004773 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 509170004774 putative GSH binding site [chemical binding]; other site 509170004775 catalytic residues [active] 509170004776 replication factor-a protein 1 (rpa1); Region: rpa1; TIGR00617 509170004777 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004778 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004779 LysR family transcriptional regulator; Provisional; Region: PRK14997 509170004780 Helix-turn-helix domains; Region: HTH; cl00088 509170004781 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 509170004782 putative effector binding pocket; other site 509170004783 putative dimerization interface [polypeptide binding]; other site 509170004784 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509170004785 active site 509170004786 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 509170004787 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004788 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004789 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170004790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170004791 dimerization interface [polypeptide binding]; other site 509170004792 putative DNA binding site [nucleotide binding]; other site 509170004793 putative Zn2+ binding site [ion binding]; other site 509170004794 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 509170004795 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 509170004796 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 509170004797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509170004798 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509170004799 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 509170004800 Walker A/P-loop; other site 509170004801 ATP binding site [chemical binding]; other site 509170004802 Q-loop/lid; other site 509170004803 ABC transporter signature motif; other site 509170004804 Walker B; other site 509170004805 D-loop; other site 509170004806 H-loop/switch region; other site 509170004807 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 509170004808 putative active site [active] 509170004809 putative catalytic site [active] 509170004810 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170004811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004813 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 509170004814 lipoyl attachment site [posttranslational modification]; other site 509170004815 NAD-dependent deacetylase; Provisional; Region: PRK00481 509170004816 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 509170004817 NAD+ binding site [chemical binding]; other site 509170004818 substrate binding site [chemical binding]; other site 509170004819 Zn binding site [ion binding]; other site 509170004820 Transposase domain (DUF772); Region: DUF772; cl15789 509170004821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004822 Sodium:solute symporter family; Region: SSF; cl00456 509170004823 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 509170004824 Helix-turn-helix domains; Region: HTH; cl00088 509170004825 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 509170004826 Proline dehydrogenase; Region: Pro_dh; cl03282 509170004827 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 509170004828 Glutamate binding site [chemical binding]; other site 509170004829 NAD binding site [chemical binding]; other site 509170004830 catalytic residues [active] 509170004831 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004832 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004833 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004834 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170004836 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 509170004837 Predicted periplasmic protein [Function unknown]; Region: COG3698 509170004838 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 509170004839 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 509170004840 YceI-like domain; Region: YceI; cl01001 509170004841 OsmC-like protein; Region: OsmC; cl00767 509170004842 transketolase; Reviewed; Region: PRK12753 509170004843 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 509170004844 TPP-binding site [chemical binding]; other site 509170004845 dimer interface [polypeptide binding]; other site 509170004846 Plant ATP synthase F0; Region: YMF19; cl07975 509170004847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509170004848 PYR/PP interface [polypeptide binding]; other site 509170004849 dimer interface [polypeptide binding]; other site 509170004850 TPP binding site [chemical binding]; other site 509170004851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509170004852 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004853 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004854 S-adenosylmethionine synthetase; Validated; Region: PRK05250 509170004855 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 509170004856 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 509170004857 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 509170004858 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 509170004859 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 509170004860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170004861 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170004862 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 509170004863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170004864 non-specific DNA binding site [nucleotide binding]; other site 509170004865 salt bridge; other site 509170004866 sequence-specific DNA binding site [nucleotide binding]; other site 509170004867 Cupin domain; Region: Cupin_2; cl09118 509170004868 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 509170004869 active site 509170004870 putative DNA-binding cleft [nucleotide binding]; other site 509170004871 dimer interface [polypeptide binding]; other site 509170004872 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170004873 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170004874 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 509170004875 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 509170004876 biotin synthase; Provisional; Region: PRK15108 509170004877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170004878 FeS/SAM binding site; other site 509170004879 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 509170004880 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170004883 Helix-turn-helix domains; Region: HTH; cl00088 509170004884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170004885 dimerization interface [polypeptide binding]; other site 509170004886 EamA-like transporter family; Region: EamA; cl01037 509170004887 Sodium:solute symporter family; Region: SSF; cl00456 509170004888 Predicted membrane protein [Function unknown]; Region: COG4125 509170004889 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170004890 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170004891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170004892 Helix-turn-helix domains; Region: HTH; cl00088 509170004893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170004894 dimerization interface [polypeptide binding]; other site 509170004895 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004896 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004897 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phage integrase (part 2) 509170004898 Transposase domain (DUF772); Region: DUF772; cl15789 509170004899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004900 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of phage integrase (part 1) 509170004901 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004902 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170004903 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 509170004904 putative acyl-acceptor binding pocket; other site 509170004905 Transcriptional regulator; Region: Transcrip_reg; cl00361 509170004906 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509170004907 Helix-turn-helix domains; Region: HTH; cl00088 509170004908 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170004909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004910 Transposase domain (DUF772); Region: DUF772; cl15789 509170004911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004912 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 509170004913 C-terminal domain interface [polypeptide binding]; other site 509170004914 GSH binding site (G-site) [chemical binding]; other site 509170004915 dimer interface [polypeptide binding]; other site 509170004916 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 509170004917 N-terminal domain interface [polypeptide binding]; other site 509170004918 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170004919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170004920 active site 509170004921 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170004922 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170004923 Flavin binding site [chemical binding]; other site 509170004924 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 509170004925 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 509170004926 active site 509170004927 non-prolyl cis peptide bond; other site 509170004928 NMT1-like family; Region: NMT1_2; cl15260 509170004929 NMT1-like family; Region: NMT1_2; cl15260 509170004930 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509170004931 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 509170004932 Walker A/P-loop; other site 509170004933 ATP binding site [chemical binding]; other site 509170004934 Q-loop/lid; other site 509170004935 ABC transporter signature motif; other site 509170004936 Walker B; other site 509170004937 D-loop; other site 509170004938 H-loop/switch region; other site 509170004939 NIL domain; Region: NIL; cl09633 509170004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 509170004941 dimer interface [polypeptide binding]; other site 509170004942 conserved gate region; other site 509170004943 ABC-ATPase subunit interface; other site 509170004944 GTP-binding protein YchF; Reviewed; Region: PRK09601 509170004945 YchF GTPase; Region: YchF; cd01900 509170004946 G1 box; other site 509170004947 GTP/Mg2+ binding site [chemical binding]; other site 509170004948 Switch I region; other site 509170004949 G2 box; other site 509170004950 Switch II region; other site 509170004951 G3 box; other site 509170004952 G4 box; other site 509170004953 G5 box; other site 509170004954 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 509170004955 Protein of unknown function (DUF962); Region: DUF962; cl01879 509170004956 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509170004957 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509170004958 ligand binding site [chemical binding]; other site 509170004959 flexible hinge region; other site 509170004960 Helix-turn-helix domains; Region: HTH; cl00088 509170004961 Transposase domain (DUF772); Region: DUF772; cl15789 509170004962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170004963 AzlC protein; Region: AzlC; cl00570 509170004964 putative L-valine exporter; Provisional; Region: PRK10408 509170004965 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 509170004966 trimer interface [polypeptide binding]; other site 509170004967 putative substrate binding pocket [chemical binding]; other site 509170004968 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 509170004969 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 509170004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170004971 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170004972 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 509170004973 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 509170004974 metal binding triad; other site 509170004975 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 509170004976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170004977 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 509170004978 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 509170004979 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 509170004980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170004981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004982 homodimer interface [polypeptide binding]; other site 509170004983 catalytic residue [active] 509170004984 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino acid efflux protein, threonine efflux protein (part 2) 509170004985 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of amino acid efflux protein, threonine efflux protein (part 1) 509170004986 Cupin domain; Region: Cupin_2; cl09118 509170004987 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170004988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170004990 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 509170004991 catalytic residues [active] 509170004992 dimer interface [polypeptide binding]; other site 509170004993 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 509170004994 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 509170004995 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 509170004996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170004997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170004998 homodimer interface [polypeptide binding]; other site 509170004999 catalytic residue [active] 509170005000 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005001 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005002 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 509170005003 active site 509170005004 homodimer interface [polypeptide binding]; other site 509170005005 homotetramer interface [polypeptide binding]; other site 509170005006 Transposase domain (DUF772); Region: DUF772; cl15789 509170005007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005008 NMT1-like family; Region: NMT1_2; cl15260 509170005009 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA-repair protein (UmuC-like) (part 1) 509170005010 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of DNA-repair protein (UmuC-like) (part 2) 509170005011 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 509170005012 trimer interface [polypeptide binding]; other site 509170005013 active site 509170005014 dimer interface [polypeptide binding]; other site 509170005015 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 509170005016 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170005017 carboxyltransferase (CT) interaction site; other site 509170005018 biotinylation site [posttranslational modification]; other site 509170005019 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 509170005020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170005021 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170005022 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 509170005023 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005024 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170005026 Helix-turn-helix domains; Region: HTH; cl00088 509170005027 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005028 Transposase domain (DUF772); Region: DUF772; cl15789 509170005029 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005030 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005031 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509170005032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170005033 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 509170005034 putative active site [active] 509170005035 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 509170005036 FAD binding domain; Region: FAD_binding_4; pfam01565 509170005037 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 509170005038 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509170005039 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 509170005040 active site 509170005041 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 509170005042 Transposase domain (DUF772); Region: DUF772; cl15789 509170005043 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005044 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 509170005045 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 509170005046 putative active site [active] 509170005047 metal binding site [ion binding]; metal-binding site 509170005048 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170005049 active site 509170005050 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 509170005051 Phosphoesterase family; Region: Phosphoesterase; cl15450 509170005052 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170005053 Domain of unknown function (DUF756); Region: DUF756; pfam05506 509170005054 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 509170005055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005056 Walker A motif; other site 509170005057 ATP binding site [chemical binding]; other site 509170005058 Walker B motif; other site 509170005059 arginine finger; other site 509170005060 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 509170005061 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 509170005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170005063 putative substrate translocation pore; other site 509170005064 TetR family transcriptional regulator; Provisional; Region: PRK14996 509170005065 Helix-turn-helix domains; Region: HTH; cl00088 509170005066 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170005067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509170005068 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509170005069 active site 2 [active] 509170005070 active site 1 [active] 509170005071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 509170005072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005073 NAD(P) binding site [chemical binding]; other site 509170005074 active site 509170005075 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 509170005076 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170005077 dimer interface [polypeptide binding]; other site 509170005078 active site 509170005079 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005080 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 509170005081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005082 Helix-turn-helix domains; Region: HTH; cl00088 509170005083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170005084 dimerization interface [polypeptide binding]; other site 509170005085 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 509170005086 transaldolase-like protein; Provisional; Region: PTZ00411 509170005087 active site 509170005088 dimer interface [polypeptide binding]; other site 509170005089 catalytic residue [active] 509170005090 LysE type translocator; Region: LysE; cl00565 509170005091 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 509170005092 Helix-turn-helix domains; Region: HTH; cl00088 509170005093 Benzoate membrane transport protein; Region: BenE; pfam03594 509170005094 benzoate transporter; Region: benE; TIGR00843 509170005095 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 509170005096 MgtC family; Region: MgtC; pfam02308 509170005097 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 509170005098 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 509170005099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509170005100 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 509170005101 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509170005102 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005103 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005104 dipeptidase PepV; Reviewed; Region: PRK07318 509170005105 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005106 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005107 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 509170005108 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005110 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 509170005111 putative cyanate transporter; Provisional; Region: cynX; PRK09705 509170005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170005113 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509170005114 nucleoside/Zn binding site; other site 509170005115 dimer interface [polypeptide binding]; other site 509170005116 catalytic motif [active] 509170005117 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170005118 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170005119 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 509170005120 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170005121 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170005122 Helix-turn-helix domains; Region: HTH; cl00088 509170005123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170005124 dimerization interface [polypeptide binding]; other site 509170005125 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 509170005126 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 509170005127 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 509170005128 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 509170005129 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 509170005130 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 509170005131 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 509170005132 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 509170005133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005134 Walker A motif; other site 509170005135 ATP binding site [chemical binding]; other site 509170005136 Walker B motif; other site 509170005137 arginine finger; other site 509170005138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005139 Walker A motif; other site 509170005140 ATP binding site [chemical binding]; other site 509170005141 Walker B motif; other site 509170005142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 509170005143 PAAR motif; Region: PAAR_motif; cl15808 509170005144 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 509170005145 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170005146 ligand binding site [chemical binding]; other site 509170005147 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 509170005148 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 509170005149 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 509170005150 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 509170005151 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 509170005152 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 509170005153 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 509170005154 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 509170005155 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 509170005156 Protein of unknown function (DUF796); Region: DUF796; cl01226 509170005157 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 509170005158 Protein of unknown function (DUF877); Region: DUF877; pfam05943 509170005159 Protein of unknown function (DUF770); Region: DUF770; cl01402 509170005160 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005162 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 509170005163 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 509170005164 putative Cl- selectivity filter; other site 509170005165 putative pore gating glutamate residue; other site 509170005166 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 509170005167 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170005168 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170005169 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 509170005170 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170005171 carboxyltransferase (CT) interaction site; other site 509170005172 biotinylation site [posttranslational modification]; other site 509170005173 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 509170005174 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 509170005175 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 509170005176 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 509170005177 LamB/YcsF family; Region: LamB_YcsF; cl00664 509170005178 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 509170005179 Transposase domain (DUF772); Region: DUF772; cl15789 509170005180 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005181 RHS protein; Region: RHS; pfam03527 509170005182 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 509170005183 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 509170005184 RHS Repeat; Region: RHS_repeat; cl11982 509170005185 RHS Repeat; Region: RHS_repeat; cl11982 509170005186 RHS Repeat; Region: RHS_repeat; cl11982 509170005187 RHS Repeat; Region: RHS_repeat; cl11982 509170005188 RHS Repeat; Region: RHS_repeat; cl11982 509170005189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 509170005190 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170005191 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 509170005192 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 509170005193 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 509170005194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170005195 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005196 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005197 Transposase domain (DUF772); Region: DUF772; cl15789 509170005198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005199 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005200 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005203 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170005204 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005206 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005207 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005208 Protein of unknown function (DUF454); Region: DUF454; cl01063 509170005209 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 509170005210 heme binding pocket [chemical binding]; other site 509170005211 heme ligand [chemical binding]; other site 509170005212 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170005213 TPR repeat; Region: TPR_11; pfam13414 509170005214 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 509170005215 Secretin and TonB N terminus short domain; Region: STN; cl06624 509170005216 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 509170005217 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 509170005218 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 509170005219 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transmembrane sensor protein (iron transport) (part 2) 509170005220 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transmembrane sensor protein (iron transport) (part 1) 509170005221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509170005222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170005223 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 509170005224 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 3) 509170005225 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 2) 509170005226 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of RHS-related protein (part 1) 509170005227 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005228 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of peptide methionine sulfoxide reductase (Protein-methionine-S-oxide reductase) (Peptide Met(O) reductase) (partial) 509170005229 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509170005230 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 509170005231 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509170005232 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170005233 Transposase domain (DUF772); Region: DUF772; cl15789 509170005234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005235 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 1) 509170005236 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 2) 509170005237 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 3) 509170005238 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 4) 509170005239 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005240 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005241 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 509170005242 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 509170005243 catalytic residues [active] 509170005244 catalytic nucleophile [active] 509170005245 Helix-turn-helix domains; Region: HTH; cl00088 509170005246 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005248 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 509170005249 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 509170005250 trimer interface [polypeptide binding]; other site 509170005251 active site 509170005252 substrate binding site [chemical binding]; other site 509170005253 CoA binding site [chemical binding]; other site 509170005254 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 509170005255 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 509170005256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170005257 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 509170005258 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 509170005259 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170005260 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170005261 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 509170005262 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 509170005263 putative active site [active] 509170005264 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509170005265 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 509170005266 Walker A/P-loop; other site 509170005267 ATP binding site [chemical binding]; other site 509170005268 Q-loop/lid; other site 509170005269 ABC transporter signature motif; other site 509170005270 Walker B; other site 509170005271 D-loop; other site 509170005272 H-loop/switch region; other site 509170005273 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170005274 Transposase domain (DUF772); Region: DUF772; cl15789 509170005275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005276 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 509170005277 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 509170005278 Walker A/P-loop; other site 509170005279 ATP binding site [chemical binding]; other site 509170005280 Q-loop/lid; other site 509170005281 ABC transporter signature motif; other site 509170005282 Walker B; other site 509170005283 D-loop; other site 509170005284 H-loop/switch region; other site 509170005285 OstA-like protein; Region: OstA; cl00844 509170005286 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 509170005287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 509170005288 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170005289 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 509170005290 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 509170005291 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 509170005292 putative active site [active] 509170005293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 509170005294 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 509170005295 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509170005296 active site 509170005297 HIGH motif; other site 509170005298 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509170005299 KMSKS motif; other site 509170005300 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 509170005301 tRNA binding surface [nucleotide binding]; other site 509170005302 anticodon binding site; other site 509170005303 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of integrase/recombinase protein (partial) 509170005304 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005306 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170005308 non-specific DNA binding site [nucleotide binding]; other site 509170005309 salt bridge; other site 509170005310 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170005311 sequence-specific DNA binding site [nucleotide binding]; other site 509170005312 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170005313 Catalytic site [active] 509170005314 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 509170005315 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 509170005316 generic binding surface II; other site 509170005317 generic binding surface I; other site 509170005318 LysE type translocator; Region: LysE; cl00565 509170005319 Transposase domain (DUF772); Region: DUF772; cl15789 509170005320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005321 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005322 Evidence 7 : Gene remnant; Product type t : transporter; fragment of C4-dicarboxylate transport protein (partial) 509170005323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170005324 Helix-turn-helix domains; Region: HTH; cl00088 509170005325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170005326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170005327 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005328 Transposase domain (DUF772); Region: DUF772; cl15789 509170005329 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005330 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005331 Protein of unknown function (DUF330); Region: DUF330; cl01135 509170005332 mce related protein; Region: MCE; pfam02470 509170005333 mce related protein; Region: MCE; pfam02470 509170005334 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 509170005335 mce related protein; Region: MCE; pfam02470 509170005336 Paraquat-inducible protein A; Region: PqiA; pfam04403 509170005337 Paraquat-inducible protein A; Region: PqiA; pfam04403 509170005338 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005339 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005340 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 509170005341 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 509170005342 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005343 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005344 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005345 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005346 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 509170005347 Found in ATP-dependent protease La (LON); Region: LON; smart00464 509170005348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170005349 Walker A motif; other site 509170005350 ATP binding site [chemical binding]; other site 509170005351 Walker B motif; other site 509170005352 arginine finger; other site 509170005353 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 509170005354 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 509170005355 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 509170005356 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 509170005357 putative active site [active] 509170005358 metal binding site [ion binding]; metal-binding site 509170005359 META domain; Region: META; cl01245 509170005360 META domain; Region: META; cl01245 509170005361 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 509170005362 glutamate dehydrogenase; Provisional; Region: PRK09414 509170005363 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509170005364 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 509170005365 NAD(P) binding site [chemical binding]; other site 509170005366 electron transport complex protein RnfB; Provisional; Region: PRK05113 509170005367 Putative Fe-S cluster; Region: FeS; pfam04060 509170005368 4Fe-4S binding domain; Region: Fer4; cl02805 509170005369 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 509170005370 endonuclease III; Provisional; Region: PRK10702 509170005371 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509170005372 minor groove reading motif; other site 509170005373 helix-hairpin-helix signature motif; other site 509170005374 substrate binding pocket [chemical binding]; other site 509170005375 active site 509170005376 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 509170005377 adenylate kinase; Reviewed; Region: adk; PRK00279 509170005378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 509170005379 AMP-binding site [chemical binding]; other site 509170005380 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 509170005381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 509170005382 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 509170005383 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509170005384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170005385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 509170005386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170005387 S-adenosylmethionine binding site [chemical binding]; other site 509170005388 HupE / UreJ protein; Region: HupE_UreJ; cl01011 509170005389 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005390 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 509170005391 UreF; Region: UreF; pfam01730 509170005392 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 509170005393 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 509170005394 dimer interface [polypeptide binding]; other site 509170005395 catalytic residues [active] 509170005396 Transposase domain (DUF772); Region: DUF772; cl15789 509170005397 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005398 urease subunit alpha; Reviewed; Region: ureC; PRK13207 509170005399 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 509170005400 subunit interactions [polypeptide binding]; other site 509170005401 active site 509170005402 flap region; other site 509170005403 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170005405 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 509170005406 gamma-beta subunit interface [polypeptide binding]; other site 509170005407 alpha-beta subunit interface [polypeptide binding]; other site 509170005408 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 509170005409 alpha-gamma subunit interface [polypeptide binding]; other site 509170005410 beta-gamma subunit interface [polypeptide binding]; other site 509170005411 UreD urease accessory protein; Region: UreD; cl00530 509170005412 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005413 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005414 NlpE N-terminal domain; Region: NlpE; cl01138 509170005415 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 509170005416 tetramer interface [polypeptide binding]; other site 509170005417 active site 509170005418 Mg2+/Mn2+ binding site [ion binding]; other site 509170005419 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 509170005420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170005421 Helix-turn-helix domains; Region: HTH; cl00088 509170005422 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 509170005423 substrate binding pocket [chemical binding]; other site 509170005424 dimerization interface [polypeptide binding]; other site 509170005425 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 509170005426 Domain of unknown function DUF21; Region: DUF21; pfam01595 509170005427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170005428 Transporter associated domain; Region: CorC_HlyC; cl08393 509170005429 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005430 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005431 Evidence 7 : Gene remnant; Product type t : transporter; fragment of citrate transporter (partial) 509170005432 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005433 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005434 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005435 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 509170005436 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 509170005437 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 509170005438 CysD dimerization site [polypeptide binding]; other site 509170005439 G1 box; other site 509170005440 putative GEF interaction site [polypeptide binding]; other site 509170005441 GTP/Mg2+ binding site [chemical binding]; other site 509170005442 Switch I region; other site 509170005443 G2 box; other site 509170005444 G3 box; other site 509170005445 Switch II region; other site 509170005446 G4 box; other site 509170005447 G5 box; other site 509170005448 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 509170005449 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 509170005450 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 509170005451 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 509170005452 Active Sites [active] 509170005453 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 509170005454 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 509170005455 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 509170005456 dimer interface [polypeptide binding]; other site 509170005457 putative anticodon binding site; other site 509170005458 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 509170005459 motif 1; other site 509170005460 active site 509170005461 motif 2; other site 509170005462 motif 3; other site 509170005463 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 509170005464 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005465 Transposase domain (DUF772); Region: DUF772; cl15789 509170005466 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 509170005468 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 509170005469 Helix-turn-helix domains; Region: HTH; cl00088 509170005470 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 509170005471 dimerization interface [polypeptide binding]; other site 509170005472 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 509170005473 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170005474 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 509170005475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170005476 Rubredoxin [Energy production and conversion]; Region: COG1773 509170005477 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 509170005478 iron binding site [ion binding]; other site 509170005479 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005480 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005481 polyphosphate kinase; Provisional; Region: PRK05443 509170005482 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 509170005483 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 509170005484 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509170005485 putative active site [active] 509170005486 catalytic site [active] 509170005487 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 509170005488 putative active site [active] 509170005489 putative domain interface [polypeptide binding]; other site 509170005490 catalytic site [active] 509170005491 Transglycosylase; Region: Transgly; cl07896 509170005492 Rhomboid family; Region: Rhomboid; cl11446 509170005493 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170005494 Transposase domain (DUF772); Region: DUF772; cl15789 509170005495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005496 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005497 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005498 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (part 2) 509170005499 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transport protein (ABC superfamily, atp_bind) (part 1) 509170005500 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 509170005501 active site 509170005502 catalytic triad [active] 509170005503 oxyanion hole [active] 509170005504 switch loop; other site 509170005505 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 509170005506 active site clefts [active] 509170005507 zinc binding site [ion binding]; other site 509170005508 dimer interface [polypeptide binding]; other site 509170005509 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 509170005510 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170005511 nucleophilic elbow; other site 509170005512 catalytic triad; other site 509170005513 outer membrane receptor FepA; Provisional; Region: PRK13524 509170005514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170005515 N-terminal plug; other site 509170005516 ligand-binding site [chemical binding]; other site 509170005517 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 509170005518 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 509170005519 NifU-like domain; Region: NifU; cl00484 509170005520 Rhomboid family; Region: Rhomboid; cl11446 509170005521 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 509170005522 Sulfatase; Region: Sulfatase; cl10460 509170005523 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005524 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005525 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005526 Phosphate transporter family; Region: PHO4; cl00396 509170005527 Phosphate transporter family; Region: PHO4; cl00396 509170005528 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005529 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005530 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of aerobic C4-dicarboxylate transport protein (partial) 509170005531 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 509170005532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005533 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 509170005534 MarC family integral membrane protein; Region: MarC; cl00919 509170005535 BCCT family transporter; Region: BCCT; cl00569 509170005536 BCCT family transporter; Region: BCCT; cl00569 509170005537 transcriptional regulator BetI; Validated; Region: PRK00767 509170005538 Helix-turn-helix domains; Region: HTH; cl00088 509170005539 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 509170005540 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170005541 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 509170005542 tetrameric interface [polypeptide binding]; other site 509170005543 NAD binding site [chemical binding]; other site 509170005544 catalytic residues [active] 509170005545 choline dehydrogenase; Validated; Region: PRK02106 509170005546 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 509170005547 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005549 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005551 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170005552 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005553 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005554 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005555 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005556 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of site-specific recombinase, integrase from bacteriophage (partial) 509170005557 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 509170005558 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 509170005559 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 509170005560 active site 509170005561 oxyanion hole [active] 509170005562 catalytic triad [active] 509170005563 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 509170005564 Baseplate J-like protein; Region: Baseplate_J; cl01294 509170005565 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 509170005566 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509170005567 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509170005568 catalytic residue [active] 509170005569 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 509170005570 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 509170005571 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 509170005572 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 509170005573 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 509170005574 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 509170005575 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 509170005576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 509170005577 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 509170005578 large terminase protein; Provisional; Region: 17; PHA02533 509170005579 Phage terminase large subunit; Region: Terminase_3; cl12054 509170005580 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 509170005581 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 509170005582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170005583 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 509170005584 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 509170005585 Helix-turn-helix domains; Region: HTH; cl00088 509170005586 fatty acid oxidation complex, alpha subunit, mitochondrial; Region: fa_ox_alpha_mit; TIGR02441 509170005587 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 509170005588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170005589 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170005590 Catalytic site [active] 509170005591 KTSC domain; Region: KTSC; pfam13619 509170005592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005593 Walker A motif; other site 509170005594 ATP binding site [chemical binding]; other site 509170005595 Walker B motif; other site 509170005596 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 509170005597 integrase; Provisional; Region: PRK09692 509170005598 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170005599 active site 509170005600 Int/Topo IB signature motif; other site 509170005601 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 509170005602 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 509170005603 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance transmembrane protein (MFS superfamily) (EmrB) (part 2) 509170005604 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance transmembrane protein (MFS superfamily) (EmrB) (part 1) 509170005605 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance secretion protein (EmrA) 509170005606 Transposase domain (DUF772); Region: DUF772; cl15789 509170005607 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005608 Evidence 7 : Gene remnant; Product type t : transporter; fragment of multidrug resistance secretion protein (part 1) 509170005609 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 509170005610 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170005611 CoenzymeA binding site [chemical binding]; other site 509170005612 subunit interaction site [polypeptide binding]; other site 509170005613 PHB binding site; other site 509170005614 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 509170005615 dimer interface [polypeptide binding]; other site 509170005616 allosteric magnesium binding site [ion binding]; other site 509170005617 active site 509170005618 aspartate-rich active site metal binding site; other site 509170005619 Schiff base residues; other site 509170005620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005621 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 509170005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170005624 TIGR01777 family protein; Region: yfcH 509170005625 NAD(P) binding site [chemical binding]; other site 509170005626 active site 509170005627 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 509170005628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170005629 OsmC-like protein; Region: OsmC; cl00767 509170005630 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509170005631 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 509170005632 active site 509170005633 metal binding site [ion binding]; metal-binding site 509170005634 DNA binding site [nucleotide binding] 509170005635 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 509170005636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005637 Walker A/P-loop; other site 509170005638 ATP binding site [chemical binding]; other site 509170005639 Q-loop/lid; other site 509170005640 exonuclease subunit SbcC; Provisional; Region: PRK10246 509170005641 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 509170005642 ABC transporter signature motif; other site 509170005643 Walker B; other site 509170005644 D-loop; other site 509170005645 H-loop/switch region; other site 509170005646 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 509170005647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509170005648 catalytic residue [active] 509170005649 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 1) 509170005650 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 2) 509170005651 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 1) 509170005652 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of twitching motility protein (part 2) 509170005653 ferric uptake regulator; Provisional; Region: fur; PRK09462 509170005654 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509170005655 metal binding site 2 [ion binding]; metal-binding site 509170005656 putative DNA binding helix; other site 509170005657 metal binding site 1 [ion binding]; metal-binding site 509170005658 dimer interface [polypeptide binding]; other site 509170005659 structural Zn2+ binding site [ion binding]; other site 509170005660 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 509170005661 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 509170005662 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005663 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005664 Transposase domain (DUF772); Region: DUF772; cl15789 509170005665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005666 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005667 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005668 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 509170005669 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 509170005670 putative active site [active] 509170005671 putative dimer interface [polypeptide binding]; other site 509170005672 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005673 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 509170005674 feedback inhibition sensing region; other site 509170005675 homohexameric interface [polypeptide binding]; other site 509170005676 nucleotide binding site [chemical binding]; other site 509170005677 N-acetyl-L-glutamate binding site [chemical binding]; other site 509170005678 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 509170005679 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509170005680 active site 509170005681 substrate binding site [chemical binding]; other site 509170005682 metal binding site [ion binding]; metal-binding site 509170005683 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509170005684 trimer interface [polypeptide binding]; other site 509170005685 active site 509170005686 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 509170005687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005688 Family description; Region: UvrD_C_2; cl15862 509170005689 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509170005690 ligand binding site [chemical binding]; other site 509170005691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 509170005692 putative acyl-acceptor binding pocket; other site 509170005693 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 509170005694 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 509170005695 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 509170005696 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 509170005697 Switch I; other site 509170005698 Switch II; other site 509170005699 Septum formation topological specificity factor MinE; Region: MinE; cl00538 509170005700 Transposase domain (DUF772); Region: DUF772; cl15789 509170005701 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005702 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 509170005703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005704 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 509170005705 thioredoxin reductase; Provisional; Region: PRK10262 509170005706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 509170005707 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005708 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 509170005709 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 509170005710 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509170005711 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 509170005712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170005713 Coenzyme A binding pocket [chemical binding]; other site 509170005714 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170005715 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170005716 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 509170005717 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 509170005718 elongation factor Tu; Reviewed; Region: PRK00049 509170005719 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509170005720 G1 box; other site 509170005721 GEF interaction site [polypeptide binding]; other site 509170005722 GTP/Mg2+ binding site [chemical binding]; other site 509170005723 Switch I region; other site 509170005724 G2 box; other site 509170005725 G3 box; other site 509170005726 Switch II region; other site 509170005727 G4 box; other site 509170005728 G5 box; other site 509170005729 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509170005730 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509170005731 Antibiotic Binding Site [chemical binding]; other site 509170005732 elongation factor G; Reviewed; Region: PRK00007 509170005733 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 509170005734 G1 box; other site 509170005735 putative GEF interaction site [polypeptide binding]; other site 509170005736 GTP/Mg2+ binding site [chemical binding]; other site 509170005737 Switch I region; other site 509170005738 G2 box; other site 509170005739 G3 box; other site 509170005740 Switch II region; other site 509170005741 G4 box; other site 509170005742 G5 box; other site 509170005743 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 509170005744 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 509170005745 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 509170005746 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 509170005747 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 509170005748 S17 interaction site [polypeptide binding]; other site 509170005749 S8 interaction site; other site 509170005750 16S rRNA interaction site [nucleotide binding]; other site 509170005751 streptomycin interaction site [chemical binding]; other site 509170005752 23S rRNA interaction site [nucleotide binding]; other site 509170005753 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 509170005754 EcsC protein family; Region: EcsC; pfam12787 509170005755 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 509170005756 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 509170005757 dimer interface [polypeptide binding]; other site 509170005758 active site 509170005759 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 509170005760 Pirin-related protein [General function prediction only]; Region: COG1741 509170005761 Cupin domain; Region: Cupin_2; cl09118 509170005762 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 509170005763 NAD synthetase; Provisional; Region: PRK13981 509170005764 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 509170005765 multimer interface [polypeptide binding]; other site 509170005766 active site 509170005767 catalytic triad [active] 509170005768 protein interface 1 [polypeptide binding]; other site 509170005769 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 509170005770 homodimer interface [polypeptide binding]; other site 509170005771 NAD binding pocket [chemical binding]; other site 509170005772 ATP binding pocket [chemical binding]; other site 509170005773 Mg binding site [ion binding]; other site 509170005774 active-site loop [active] 509170005775 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 509170005776 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 509170005777 FMN-binding pocket [chemical binding]; other site 509170005778 flavin binding motif; other site 509170005779 phosphate binding motif [ion binding]; other site 509170005780 beta-alpha-beta structure motif; other site 509170005781 NAD binding pocket [chemical binding]; other site 509170005782 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170005783 catalytic loop [active] 509170005784 iron binding site [ion binding]; other site 509170005785 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Succinate-semialdehyde dehydrogenase [NADP+] (SSDH) (partial) 509170005786 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005787 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005788 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 509170005789 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 509170005790 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 509170005791 active site 509170005792 (T/H)XGH motif; other site 509170005793 integrase; Provisional; Region: PRK09692 509170005794 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 509170005795 active site 509170005796 Int/Topo IB signature motif; other site 509170005797 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of lysozyme from bacteriophage 509170005798 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005799 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005801 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005802 Transposase domain (DUF772); Region: DUF772; cl15789 509170005803 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005804 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005805 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 509170005806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170005807 Predicted transcriptional regulator [Transcription]; Region: COG2932 509170005808 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 509170005809 Catalytic site [active] 509170005810 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005811 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005813 replicative DNA helicase; Provisional; Region: PRK08840 509170005814 ERF superfamily; Region: ERF; pfam04404 509170005815 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; phage-related protein (part 1) 509170005816 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005817 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005818 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; phage-related protein (part 2) 509170005819 BRO family, N-terminal domain; Region: Bro-N; cl10591 509170005820 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509170005821 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 509170005822 SmpB-tmRNA interface; other site 509170005823 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170005824 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 509170005825 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 509170005826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170005827 RNA binding surface [nucleotide binding]; other site 509170005828 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 509170005829 active site 509170005830 Outer membrane lipoprotein; Region: YfiO; pfam13525 509170005831 DNA primase, catalytic core; Region: dnaG; TIGR01391 509170005832 CHC2 zinc finger; Region: zf-CHC2; cl15369 509170005833 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 509170005834 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 509170005835 active site 509170005836 metal binding site [ion binding]; metal-binding site 509170005837 interdomain interaction site; other site 509170005838 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 509170005839 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 509170005840 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 509170005841 tRNA; other site 509170005842 putative tRNA binding site [nucleotide binding]; other site 509170005843 putative NADP binding site [chemical binding]; other site 509170005844 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 509170005845 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 509170005846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170005847 binding surface 509170005848 TPR motif; other site 509170005849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170005850 binding surface 509170005851 TPR motif; other site 509170005852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 509170005853 binding surface 509170005854 TPR motif; other site 509170005855 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 509170005856 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 509170005857 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 509170005858 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 509170005859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170005860 active site 509170005861 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 509170005862 5S rRNA interface [nucleotide binding]; other site 509170005863 CTC domain interface [polypeptide binding]; other site 509170005864 L16 interface [polypeptide binding]; other site 509170005865 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 509170005866 putative active site [active] 509170005867 catalytic residue [active] 509170005868 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 509170005869 tetramerization interface [polypeptide binding]; other site 509170005870 active site 509170005871 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170005872 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005873 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005874 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170005875 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170005876 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 509170005877 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 509170005878 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509170005879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170005880 motif II; other site 509170005881 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 509170005882 dimer interface [polypeptide binding]; other site 509170005883 substrate binding site [chemical binding]; other site 509170005884 ATP binding site [chemical binding]; other site 509170005885 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 509170005886 BON domain; Region: BON; cl02771 509170005887 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509170005888 putative peptidoglycan binding site; other site 509170005889 Phosphopantetheine attachment site; Region: PP-binding; cl09936 509170005890 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 509170005891 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 509170005892 NAD(P) binding site [chemical binding]; other site 509170005893 homotetramer interface [polypeptide binding]; other site 509170005894 homodimer interface [polypeptide binding]; other site 509170005895 active site 509170005896 Acyl transferase domain; Region: Acyl_transf_1; cl08282 509170005897 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 509170005898 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 509170005899 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 509170005900 Protein of unknown function, DUF462; Region: DUF462; cl01190 509170005901 Transposase domain (DUF772); Region: DUF772; cl15789 509170005902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005903 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 509170005904 ScpA/B protein; Region: ScpA_ScpB; cl00598 509170005905 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 509170005906 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509170005907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170005908 RNA binding surface [nucleotide binding]; other site 509170005909 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 509170005910 probable active site [active] 509170005911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170005913 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 509170005914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170005915 S-adenosylmethionine binding site [chemical binding]; other site 509170005916 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 509170005917 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509170005918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170005919 catalytic residue [active] 509170005920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170005921 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 509170005922 inhibitor-cofactor binding pocket; inhibition site 509170005923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170005924 catalytic residue [active] 509170005925 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 509170005926 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 509170005927 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170005928 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 509170005929 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 509170005930 active site 509170005931 homotetramer interface [polypeptide binding]; other site 509170005932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170005933 putative substrate translocation pore; other site 509170005934 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 509170005935 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 509170005936 heme binding site [chemical binding]; other site 509170005937 ferroxidase pore; other site 509170005938 ferroxidase diiron center [ion binding]; other site 509170005939 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 509170005940 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 509170005941 nucleotide binding pocket [chemical binding]; other site 509170005942 K-X-D-G motif; other site 509170005943 catalytic site [active] 509170005944 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 509170005945 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 509170005946 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 509170005947 Dimer interface [polypeptide binding]; other site 509170005948 BRCT sequence motif; other site 509170005949 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 509170005950 FtsZ protein binding site [polypeptide binding]; other site 509170005951 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509170005952 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 509170005953 Walker A/P-loop; other site 509170005954 ATP binding site [chemical binding]; other site 509170005955 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509170005956 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 509170005957 ABC transporter signature motif; other site 509170005958 Walker B; other site 509170005959 D-loop; other site 509170005960 H-loop/switch region; other site 509170005961 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509170005962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170005963 DNA-binding site [nucleotide binding]; DNA binding site 509170005964 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509170005965 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 509170005966 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509170005967 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509170005968 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 509170005969 Type III pantothenate kinase; Region: Pan_kinase; cl09130 509170005970 signal recognition particle protein; Provisional; Region: PRK10867 509170005971 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 509170005972 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509170005973 GTP binding site [chemical binding]; other site 509170005974 Signal peptide binding domain; Region: SRP_SPB; pfam02978 509170005975 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 509170005976 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 509170005977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170005978 FMN binding site [chemical binding]; other site 509170005979 active site 509170005980 catalytic residues [active] 509170005981 substrate binding site [chemical binding]; other site 509170005982 Transposase domain (DUF772); Region: DUF772; cl15789 509170005983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005984 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170005985 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170005986 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170005987 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509170005988 trimer interface [polypeptide binding]; other site 509170005989 active site 509170005990 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of threonine efflux protein (partial) 509170005991 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005992 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170005993 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509170005994 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 509170005995 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 509170005996 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 509170005997 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 509170005998 active site 509170005999 HIGH motif; other site 509170006000 KMSKS motif; other site 509170006001 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 509170006002 tRNA binding surface [nucleotide binding]; other site 509170006003 anticodon binding site; other site 509170006004 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 509170006005 dimer interface [polypeptide binding]; other site 509170006006 putative tRNA-binding site [nucleotide binding]; other site 509170006007 LysE type translocator; Region: LysE; cl00565 509170006008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006009 Helix-turn-helix domains; Region: HTH; cl00088 509170006010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006011 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 509170006012 putative substrate translocation pore; other site 509170006013 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 509170006014 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170006015 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170006016 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 509170006017 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 509170006018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509170006019 catalytic residue [active] 509170006020 HI0933-like protein; Region: HI0933_like; pfam03486 509170006021 Conserved TM helix; Region: TM_helix; pfam05552 509170006022 Conserved TM helix; Region: TM_helix; pfam05552 509170006023 Conserved TM helix; Region: TM_helix; pfam05552 509170006024 Conserved TM helix; Region: TM_helix; pfam05552 509170006025 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006026 ferredoxin-NADP reductase; Provisional; Region: PRK10926 509170006027 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 509170006028 FAD binding pocket [chemical binding]; other site 509170006029 FAD binding motif [chemical binding]; other site 509170006030 phosphate binding motif [ion binding]; other site 509170006031 beta-alpha-beta structure motif; other site 509170006032 NAD binding pocket [chemical binding]; other site 509170006033 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 509170006034 Helix-turn-helix domains; Region: HTH; cl00088 509170006035 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 509170006036 putative dimerization interface [polypeptide binding]; other site 509170006037 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 509170006038 DNA-binding site [nucleotide binding]; DNA binding site 509170006039 RNA-binding motif; other site 509170006040 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170006041 active site 509170006042 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 509170006043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509170006044 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 509170006045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509170006046 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 509170006047 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 509170006048 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509170006049 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 509170006050 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 509170006051 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 509170006052 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 509170006053 4Fe-4S binding domain; Region: Fer4; cl02805 509170006054 4Fe-4S binding domain; Region: Fer4; cl02805 509170006055 NADH dehydrogenase; Region: NADHdh; cl00469 509170006056 NADH dehydrogenase subunit G; Validated; Region: PRK08166 509170006057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509170006058 catalytic loop [active] 509170006059 iron binding site [ion binding]; other site 509170006060 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 509170006061 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 509170006062 [4Fe-4S] binding site [ion binding]; other site 509170006063 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 509170006064 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 509170006065 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 509170006066 SLBB domain; Region: SLBB; pfam10531 509170006067 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 509170006068 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 509170006069 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 509170006070 putative dimer interface [polypeptide binding]; other site 509170006071 [2Fe-2S] cluster binding site [ion binding]; other site 509170006072 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 509170006073 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 509170006074 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 509170006075 NADH dehydrogenase subunit B; Validated; Region: PRK06411 509170006076 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 509170006077 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 509170006078 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein; GGDEF domain (part 1) 509170006079 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of membrane protein; GGDEF domain (part 2) 509170006080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 509170006081 dimerization interface [polypeptide binding]; other site 509170006082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170006083 dimer interface [polypeptide binding]; other site 509170006084 phosphorylation site [posttranslational modification] 509170006085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170006086 ATP binding site [chemical binding]; other site 509170006087 Mg2+ binding site [ion binding]; other site 509170006088 G-X-G motif; other site 509170006089 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 509170006090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170006091 active site 509170006092 phosphorylation site [posttranslational modification] 509170006093 intermolecular recognition site; other site 509170006094 dimerization interface [polypeptide binding]; other site 509170006095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170006096 DNA binding site [nucleotide binding] 509170006097 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 509170006098 ATP cone domain; Region: ATP-cone; pfam03477 509170006099 Class I ribonucleotide reductase; Region: RNR_I; cd01679 509170006100 active site 509170006101 dimer interface [polypeptide binding]; other site 509170006102 catalytic residues [active] 509170006103 effector binding site; other site 509170006104 R2 peptide binding site; other site 509170006105 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 509170006106 dimer interface [polypeptide binding]; other site 509170006107 putative radical transfer pathway; other site 509170006108 diiron center [ion binding]; other site 509170006109 tyrosyl radical; other site 509170006110 Transposase domain (DUF772); Region: DUF772; cl15789 509170006111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006112 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006113 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006114 Flavin Reductases; Region: FlaRed; cl00801 509170006115 methionine synthase; Provisional; Region: PRK01207 509170006116 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 509170006117 substrate binding site [chemical binding]; other site 509170006118 THF binding site; other site 509170006119 zinc-binding site [ion binding]; other site 509170006120 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 509170006121 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509170006122 Helix-turn-helix domains; Region: HTH; cl00088 509170006123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170006124 dimerization interface [polypeptide binding]; other site 509170006125 LysE type translocator; Region: LysE; cl00565 509170006126 Helix-turn-helix domains; Region: HTH; cl00088 509170006127 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 509170006128 putative dimerization interface [polypeptide binding]; other site 509170006129 Transposase domain (DUF772); Region: DUF772; cl15789 509170006130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006131 citrate-proton symporter; Provisional; Region: PRK15075 509170006132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006133 putative substrate translocation pore; other site 509170006134 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of substrate-binding protein (ABC superfamily, peri-bind) (part 1) 509170006135 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of substrate-binding protein (ABC superfamily, peri-bind) (part 2) 509170006136 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170006137 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006138 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006139 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of citrate utilization protein B (partial) 509170006140 HPP family; Region: HPP; pfam04982 509170006141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006142 Helix-turn-helix domains; Region: HTH; cl00088 509170006143 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 509170006144 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 509170006145 CoA-transferase family III; Region: CoA_transf_3; pfam02515 509170006146 benzoate transport; Region: 2A0115; TIGR00895 509170006147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006148 putative substrate translocation pore; other site 509170006149 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 509170006150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006151 FAD binding site [chemical binding]; other site 509170006152 substrate binding pocket [chemical binding]; other site 509170006153 catalytic base [active] 509170006154 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 509170006155 Helix-turn-helix domains; Region: HTH; cl00088 509170006156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170006157 dimerization interface [polypeptide binding]; other site 509170006158 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Zinc-binding dehydrogenase (part 2) 509170006159 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of Zinc-binding dehydrogenase (part 1) 509170006160 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 509170006161 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 509170006162 active site 509170006163 purine riboside binding site [chemical binding]; other site 509170006164 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 509170006165 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 509170006166 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170006167 DNA binding site [nucleotide binding] 509170006168 Int/Topo IB signature motif; other site 509170006169 active site 509170006170 Transposase domain (DUF772); Region: DUF772; cl15789 509170006171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006172 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509170006173 dimer interface [polypeptide binding]; other site 509170006174 ssDNA binding site [nucleotide binding]; other site 509170006175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170006176 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006177 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006178 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 509170006179 active site 509170006180 metal binding site [ion binding]; metal-binding site 509170006181 interdomain interaction site; other site 509170006182 Helix-turn-helix domain; Region: HTH_18; pfam12833 509170006183 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006184 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006185 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006186 PAAR motif; Region: PAAR_motif; cl15808 509170006187 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of phage-related DNA adenine methylase (part 1) 509170006188 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; fragment of phage-related DNA adenine methylase (part 2) 509170006189 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170006190 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 509170006191 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 509170006192 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509170006193 Phage-related protein [Function unknown]; Region: COG5412 509170006194 LysE type translocator; Region: LysE; cl00565 509170006195 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 509170006196 Phage tail tube protein FII; Region: Phage_tube; cl01390 509170006197 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 509170006198 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 509170006199 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 509170006200 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 509170006201 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 509170006202 Baseplate J-like protein; Region: Baseplate_J; cl01294 509170006203 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 509170006204 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 509170006205 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 509170006206 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 509170006207 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 509170006208 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 509170006209 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 509170006210 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 509170006211 Protein of unknown function (DUF754); Region: DUF754; pfam05449 509170006212 Phage Tail Protein X; Region: Phage_tail_X; cl02088 509170006213 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 509170006214 terminase endonuclease subunit; Provisional; Region: M; PHA02537 509170006215 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 509170006216 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 509170006217 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 509170006218 terminase ATPase subunit; Provisional; Region: P; PHA02535 509170006219 Helix-turn-helix domains; Region: HTH; cl00088 509170006220 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 509170006221 Phage-related protein [Function unknown]; Region: COG4695; cl01923 509170006222 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 509170006223 YcfA-like protein; Region: YcfA; cl00752 509170006224 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 509170006225 Transposase domain (DUF772); Region: DUF772; cl15789 509170006226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006227 Quinolinate synthetase A protein; Region: NadA; cl00420 509170006228 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 509170006229 heterotetramer interface [polypeptide binding]; other site 509170006230 active site pocket [active] 509170006231 cleavage site 509170006232 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 509170006233 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 509170006234 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509170006235 DNA binding site [nucleotide binding] 509170006236 active site 509170006237 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 509170006238 Cation efflux family; Region: Cation_efflux; cl00316 509170006239 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of copper resistance protein B precursor (partial) 509170006240 Transposase domain (DUF772); Region: DUF772; cl15789 509170006241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006242 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of copper resistance protein A precursor (partial) 509170006243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006244 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 509170006245 active site 509170006246 motif I; other site 509170006247 motif II; other site 509170006248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170006249 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 509170006250 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 509170006251 substrate binding site [chemical binding]; other site 509170006252 hexamer interface [polypeptide binding]; other site 509170006253 metal binding site [ion binding]; metal-binding site 509170006254 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 509170006255 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of esterase (part 2) 509170006256 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of esterase (part 1) 509170006257 Peptidase C13 family; Region: Peptidase_C13; cl02159 509170006258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006259 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 509170006260 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509170006261 trimer interface [polypeptide binding]; other site 509170006262 putative metal binding site [ion binding]; other site 509170006263 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 509170006264 putative active site [active] 509170006265 putative CoA binding site [chemical binding]; other site 509170006266 nudix motif; other site 509170006267 metal binding site [ion binding]; metal-binding site 509170006268 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 509170006269 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 509170006270 nudix motif; other site 509170006271 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006272 Transposase domain (DUF772); Region: DUF772; cl15789 509170006273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006274 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006275 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 509170006276 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 509170006277 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 509170006278 putative active site [active] 509170006279 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006281 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509170006282 chorismate binding enzyme; Region: Chorismate_bind; cl10555 509170006283 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 509170006284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170006285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170006286 homodimer interface [polypeptide binding]; other site 509170006287 catalytic residue [active] 509170006288 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 509170006289 histidinol dehydrogenase; Region: hisD; TIGR00069 509170006290 NAD binding site [chemical binding]; other site 509170006291 dimerization interface [polypeptide binding]; other site 509170006292 product binding site; other site 509170006293 substrate binding site [chemical binding]; other site 509170006294 zinc binding site [ion binding]; other site 509170006295 catalytic residues [active] 509170006296 ATP phosphoribosyltransferase; Region: HisG; cl15266 509170006297 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 509170006298 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509170006299 hinge; other site 509170006300 active site 509170006301 BolA-like protein; Region: BolA; cl00386 509170006302 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 509170006303 30S subunit binding site; other site 509170006304 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 509170006305 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 509170006306 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 509170006307 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 509170006308 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006309 Transposase domain (DUF772); Region: DUF772; cl15789 509170006310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006311 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006312 Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of lipoprotein precursor (partial) 509170006313 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 509170006314 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509170006315 putative active site [active] 509170006316 putative metal binding site [ion binding]; other site 509170006317 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 509170006318 putative active site [active] 509170006319 catalytic site [active] 509170006320 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 509170006321 PLD-like domain; Region: PLDc_2; pfam13091 509170006322 putative active site [active] 509170006323 catalytic site [active] 509170006324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 509170006325 putative acyl-acceptor binding pocket; other site 509170006326 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 509170006327 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 509170006328 HflX GTPase family; Region: HflX; cd01878 509170006329 G1 box; other site 509170006330 GTP/Mg2+ binding site [chemical binding]; other site 509170006331 Switch I region; other site 509170006332 G2 box; other site 509170006333 G3 box; other site 509170006334 Switch II region; other site 509170006335 G4 box; other site 509170006336 G5 box; other site 509170006337 LrgB-like family; Region: LrgB; cl00596 509170006338 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 509170006339 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 509170006340 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 509170006341 active site 509170006342 metal binding site [ion binding]; metal-binding site 509170006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006344 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 509170006345 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 509170006346 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 509170006347 23S rRNA interface [nucleotide binding]; other site 509170006348 L3 interface [polypeptide binding]; other site 509170006349 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 509170006350 stringent starvation protein A; Provisional; Region: sspA; PRK09481 509170006351 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509170006352 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 509170006353 dimer interface [polypeptide binding]; other site 509170006354 N-terminal domain interface [polypeptide binding]; other site 509170006355 Stringent starvation protein B; Region: SspB; cl01120 509170006356 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 509170006357 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509170006358 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170006359 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 509170006360 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 509170006361 carboxyltransferase (CT) interaction site; other site 509170006362 biotinylation site [posttranslational modification]; other site 509170006363 enoyl-CoA hydratase; Provisional; Region: PRK05995 509170006364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170006365 substrate binding site [chemical binding]; other site 509170006366 oxyanion hole (OAH) forming residues; other site 509170006367 trimer interface [polypeptide binding]; other site 509170006368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170006370 active site 509170006371 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 509170006372 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 509170006373 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 509170006374 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 509170006375 NAD(P) binding site [chemical binding]; other site 509170006376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 509170006377 substrate binding site [chemical binding]; other site 509170006378 homotetramer interface [polypeptide binding]; other site 509170006379 active site 509170006380 homodimer interface [polypeptide binding]; other site 509170006381 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 509170006382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170006383 Helix-turn-helix domains; Region: HTH; cl00088 509170006384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 509170006385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 509170006386 active site 509170006387 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 509170006388 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170006389 Transposase domain (DUF772); Region: DUF772; cl15789 509170006390 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006391 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006392 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006393 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170006394 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 509170006395 VacJ like lipoprotein; Region: VacJ; cl01073 509170006396 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 509170006397 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 509170006398 anti sigma factor interaction site; other site 509170006399 regulatory phosphorylation site [posttranslational modification]; other site 509170006400 Predicted amidohydrolase [General function prediction only]; Region: COG0388 509170006401 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 509170006402 putative active site [active] 509170006403 catalytic triad [active] 509170006404 dimer interface [polypeptide binding]; other site 509170006405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 509170006406 Helix-turn-helix domains; Region: HTH; cl00088 509170006407 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of organic hydroperoxide resistance protein (part 1) 509170006408 Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of organic hydroperoxide resistance protein (part 2) 509170006409 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 509170006410 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 509170006411 Walker A motif; other site 509170006412 ATP binding site [chemical binding]; other site 509170006413 Walker B motif; other site 509170006414 Protein of unknown function (DUF432); Region: DUF432; cl01027 509170006415 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170006416 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 509170006417 DNA polymerase I; Provisional; Region: PRK05755 509170006418 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 509170006419 active site 509170006420 metal binding site 1 [ion binding]; metal-binding site 509170006421 putative 5' ssDNA interaction site; other site 509170006422 metal binding site 3; metal-binding site 509170006423 metal binding site 2 [ion binding]; metal-binding site 509170006424 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 509170006425 putative DNA binding site [nucleotide binding]; other site 509170006426 putative metal binding site [ion binding]; other site 509170006427 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 509170006428 active site 509170006429 catalytic site [active] 509170006430 substrate binding site [chemical binding]; other site 509170006431 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 509170006432 active site 509170006433 DNA binding site [nucleotide binding] 509170006434 catalytic site [active] 509170006435 YGGT family; Region: YGGT; cl00508 509170006436 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 509170006437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006438 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 509170006439 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 509170006440 Ligand Binding Site [chemical binding]; other site 509170006441 TilS substrate binding domain; Region: TilS; pfam09179 509170006442 B3/4 domain; Region: B3_4; cl11458 509170006443 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 509170006444 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 509170006445 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 509170006446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509170006447 catalytic residues [active] 509170006448 transcription termination factor Rho; Provisional; Region: rho; PRK09376 509170006449 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 509170006450 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 509170006451 RNA binding site [nucleotide binding]; other site 509170006452 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 509170006453 multimer interface [polypeptide binding]; other site 509170006454 Walker A motif; other site 509170006455 ATP binding site [chemical binding]; other site 509170006456 Walker B motif; other site 509170006457 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 509170006458 IHF dimer interface [polypeptide binding]; other site 509170006459 IHF - DNA interface [nucleotide binding]; other site 509170006460 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 509170006461 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 509170006462 putative tRNA-binding site [nucleotide binding]; other site 509170006463 B3/4 domain; Region: B3_4; cl11458 509170006464 tRNA synthetase B5 domain; Region: B5; cl08394 509170006465 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 509170006466 dimer interface [polypeptide binding]; other site 509170006467 motif 1; other site 509170006468 motif 3; other site 509170006469 motif 2; other site 509170006470 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 509170006471 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 509170006472 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 509170006473 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 509170006474 dimer interface [polypeptide binding]; other site 509170006475 motif 1; other site 509170006476 active site 509170006477 motif 2; other site 509170006478 motif 3; other site 509170006479 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006480 Transposase domain (DUF772); Region: DUF772; cl15789 509170006481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006482 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 509170006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509170006485 Coenzyme A binding pocket [chemical binding]; other site 509170006486 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 509170006487 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 509170006488 23S rRNA binding site [nucleotide binding]; other site 509170006489 L21 binding site [polypeptide binding]; other site 509170006490 L13 binding site [polypeptide binding]; other site 509170006491 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 509170006492 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 1) 509170006493 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006495 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 2) 509170006496 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (part 3) 509170006497 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509170006498 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 509170006499 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 509170006500 C-terminal domain interface [polypeptide binding]; other site 509170006501 GSH binding site (G-site) [chemical binding]; other site 509170006502 dimer interface [polypeptide binding]; other site 509170006503 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 509170006504 N-terminal domain interface [polypeptide binding]; other site 509170006505 putative dimer interface [polypeptide binding]; other site 509170006506 active site 509170006507 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 509170006508 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 509170006509 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 509170006510 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 509170006511 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 509170006512 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 509170006513 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 509170006514 active site 509170006515 dimer interface [polypeptide binding]; other site 509170006516 motif 1; other site 509170006517 motif 2; other site 509170006518 motif 3; other site 509170006519 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 509170006520 anticodon binding site; other site 509170006521 acyl-CoA synthetase; Validated; Region: PRK08162 509170006522 AMP-binding enzyme; Region: AMP-binding; cl15778 509170006523 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170006524 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006525 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006526 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006527 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006528 Protein of unknown function (DUF615); Region: DUF615; cl01147 509170006529 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509170006530 dimerization domain swap beta strand [polypeptide binding]; other site 509170006531 regulatory protein interface [polypeptide binding]; other site 509170006532 active site 509170006533 regulatory phosphorylation site [posttranslational modification]; other site 509170006534 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 509170006535 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 509170006536 pantoate--beta-alanine ligase; Region: panC; TIGR00018 509170006537 Pantoate-beta-alanine ligase; Region: PanC; cd00560 509170006538 active site 509170006539 ATP-binding site [chemical binding]; other site 509170006540 pantoate-binding site; other site 509170006541 HXXH motif; other site 509170006542 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 509170006543 oligomerization interface [polypeptide binding]; other site 509170006544 active site 509170006545 metal binding site [ion binding]; metal-binding site 509170006546 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 509170006547 catalytic center binding site [active] 509170006548 ATP binding site [chemical binding]; other site 509170006549 poly(A) polymerase; Region: pcnB; TIGR01942 509170006550 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509170006551 active site 509170006552 NTP binding site [chemical binding]; other site 509170006553 metal binding triad [ion binding]; metal-binding site 509170006554 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509170006555 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 509170006556 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 509170006557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 509170006558 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 509170006559 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509170006560 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509170006561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006562 short chain dehydrogenase; Validated; Region: PRK07069 509170006563 NAD(P) binding site [chemical binding]; other site 509170006564 active site 509170006565 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006566 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006567 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509170006568 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509170006569 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509170006570 synthetase active site [active] 509170006571 NTP binding site [chemical binding]; other site 509170006572 metal binding site [ion binding]; metal-binding site 509170006573 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 509170006574 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 509170006575 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 509170006576 TRAM domain; Region: TRAM; cl01282 509170006577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170006579 S-adenosylmethionine binding site [chemical binding]; other site 509170006580 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 509170006581 active site 509170006582 catalytic site [active] 509170006583 substrate binding site [chemical binding]; other site 509170006584 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 509170006585 cysteine synthase B; Region: cysM; TIGR01138 509170006586 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 509170006587 dimer interface [polypeptide binding]; other site 509170006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170006589 catalytic residue [active] 509170006590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170006591 dimer interface [polypeptide binding]; other site 509170006592 phosphorylation site [posttranslational modification] 509170006593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170006594 ATP binding site [chemical binding]; other site 509170006595 Mg2+ binding site [ion binding]; other site 509170006596 G-X-G motif; other site 509170006597 Response regulator receiver domain; Region: Response_reg; pfam00072 509170006598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170006599 active site 509170006600 phosphorylation site [posttranslational modification] 509170006601 intermolecular recognition site; other site 509170006602 dimerization interface [polypeptide binding]; other site 509170006603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 509170006604 enoyl-CoA hydratase; Provisional; Region: PRK07509 509170006605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170006606 substrate binding site [chemical binding]; other site 509170006607 oxyanion hole (OAH) forming residues; other site 509170006608 trimer interface [polypeptide binding]; other site 509170006609 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 509170006610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006611 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 509170006612 Oligomerisation domain; Region: Oligomerisation; cl00519 509170006613 Transposase domain (DUF772); Region: DUF772; cl15789 509170006614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006615 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 509170006616 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 509170006617 putative NAD(P) binding site [chemical binding]; other site 509170006618 active site 509170006619 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 509170006620 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 509170006621 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 509170006622 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 509170006623 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 509170006624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006625 EamA-like transporter family; Region: EamA; cl01037 509170006626 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170006627 EamA-like transporter family; Region: EamA; cl01037 509170006628 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509170006629 homotrimer interaction site [polypeptide binding]; other site 509170006630 putative active site [active] 509170006631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170006632 putative substrate translocation pore; other site 509170006633 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 509170006634 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 509170006635 FMN binding site [chemical binding]; other site 509170006636 active site 509170006637 catalytic residues [active] 509170006638 substrate binding site [chemical binding]; other site 509170006639 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170006640 Helix-turn-helix domains; Region: HTH; cl00088 509170006641 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 509170006642 dimerization interface [polypeptide binding]; other site 509170006643 substrate binding pocket [chemical binding]; other site 509170006644 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 509170006645 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 509170006646 putative ATP binding site [chemical binding]; other site 509170006647 putative substrate interface [chemical binding]; other site 509170006648 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 509170006649 homotrimer interaction site [polypeptide binding]; other site 509170006650 putative active site [active] 509170006651 aconitate hydratase; Validated; Region: PRK09277 509170006652 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 509170006653 substrate binding site [chemical binding]; other site 509170006654 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 509170006655 ligand binding site [chemical binding]; other site 509170006656 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 509170006657 substrate binding site [chemical binding]; other site 509170006658 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509170006659 active site 509170006660 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 509170006661 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170006662 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 509170006663 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 509170006664 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 509170006665 G1 box; other site 509170006666 putative GEF interaction site [polypeptide binding]; other site 509170006667 GTP/Mg2+ binding site [chemical binding]; other site 509170006668 Switch I region; other site 509170006669 G2 box; other site 509170006670 G3 box; other site 509170006671 Switch II region; other site 509170006672 G4 box; other site 509170006673 G5 box; other site 509170006674 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 509170006675 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006676 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170006677 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 3) 509170006678 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006679 Transposase domain (DUF772); Region: DUF772; cl15789 509170006680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006681 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006682 ketol-acid reductoisomerase; Provisional; Region: PRK05479 509170006683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006684 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 509170006685 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 509170006686 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 509170006687 putative valine binding site [chemical binding]; other site 509170006688 dimer interface [polypeptide binding]; other site 509170006689 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 509170006690 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 509170006691 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 509170006692 PYR/PP interface [polypeptide binding]; other site 509170006693 dimer interface [polypeptide binding]; other site 509170006694 TPP binding site [chemical binding]; other site 509170006695 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 509170006696 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 509170006697 TPP-binding site [chemical binding]; other site 509170006698 dimer interface [polypeptide binding]; other site 509170006699 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 509170006700 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 509170006701 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 509170006702 HIGH motif; other site 509170006703 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 509170006704 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170006705 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170006706 active site 509170006707 KMSKS motif; other site 509170006708 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 509170006709 tRNA binding surface [nucleotide binding]; other site 509170006710 Lipopolysaccharide-assembly; Region: LptE; cl01125 509170006711 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 509170006712 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 509170006713 macrolide transporter subunit MacA; Provisional; Region: PRK11578 509170006714 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170006715 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170006716 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 509170006717 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 509170006718 Walker A/P-loop; other site 509170006719 ATP binding site [chemical binding]; other site 509170006720 Q-loop/lid; other site 509170006721 ABC transporter signature motif; other site 509170006722 Walker B; other site 509170006723 D-loop; other site 509170006724 H-loop/switch region; other site 509170006725 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509170006726 FtsX-like permease family; Region: FtsX; cl15850 509170006727 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 509170006728 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 509170006729 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 509170006730 NAD binding site [chemical binding]; other site 509170006731 homotetramer interface [polypeptide binding]; other site 509170006732 homodimer interface [polypeptide binding]; other site 509170006733 substrate binding site [chemical binding]; other site 509170006734 active site 509170006735 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 509170006736 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 509170006737 putative active site [active] 509170006738 putative substrate binding site [chemical binding]; other site 509170006739 catalytic site [active] 509170006740 dimer interface [polypeptide binding]; other site 509170006741 GTPase RsgA; Reviewed; Region: PRK12288 509170006742 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 509170006743 RNA binding site [nucleotide binding]; other site 509170006744 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 509170006745 GTPase/Zn-binding domain interface [polypeptide binding]; other site 509170006746 GTP/Mg2+ binding site [chemical binding]; other site 509170006747 G4 box; other site 509170006748 G5 box; other site 509170006749 G1 box; other site 509170006750 Switch I region; other site 509170006751 G2 box; other site 509170006752 G3 box; other site 509170006753 Switch II region; other site 509170006754 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 509170006755 active site residue [active] 509170006756 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 509170006757 GSH binding site [chemical binding]; other site 509170006758 catalytic residues [active] 509170006759 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 509170006760 SecA binding site; other site 509170006761 Preprotein binding site; other site 509170006762 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 509170006763 Transposase domain (DUF772); Region: DUF772; cl15789 509170006764 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006765 GTP-binding protein Der; Reviewed; Region: PRK00093 509170006766 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 509170006767 G1 box; other site 509170006768 GTP/Mg2+ binding site [chemical binding]; other site 509170006769 Switch I region; other site 509170006770 G2 box; other site 509170006771 Switch II region; other site 509170006772 G3 box; other site 509170006773 G4 box; other site 509170006774 G5 box; other site 509170006775 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 509170006776 G1 box; other site 509170006777 GTP/Mg2+ binding site [chemical binding]; other site 509170006778 Switch I region; other site 509170006779 G2 box; other site 509170006780 G3 box; other site 509170006781 Switch II region; other site 509170006782 G4 box; other site 509170006783 G5 box; other site 509170006784 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 509170006785 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 509170006786 Trp docking motif [polypeptide binding]; other site 509170006787 active site 509170006788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 509170006789 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 509170006790 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 509170006791 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 509170006792 dimer interface [polypeptide binding]; other site 509170006793 motif 1; other site 509170006794 active site 509170006795 motif 2; other site 509170006796 motif 3; other site 509170006797 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 509170006798 anticodon binding site; other site 509170006799 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 509170006800 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 509170006801 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 509170006802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170006803 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 509170006804 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial biogenesis protein (part 2) 509170006805 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial biogenesis protein (part 1) 509170006806 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 509170006807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170006808 FeS/SAM binding site; other site 509170006809 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 509170006810 active site 509170006811 multimer interface [polypeptide binding]; other site 509170006812 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 509170006813 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 509170006814 active site 509170006815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170006816 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 509170006817 carboxy-terminal protease; Provisional; Region: PRK11186 509170006818 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509170006819 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 509170006820 protein binding site [polypeptide binding]; other site 509170006821 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509170006822 Catalytic dyad [active] 509170006823 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 509170006824 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 509170006825 Leucine carboxyl methyltransferase; Region: LCM; cl01306 509170006826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170006827 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 509170006828 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 509170006829 putative catalytic cysteine [active] 509170006830 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 3) 509170006831 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 2) 509170006832 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (part 1) 509170006833 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 509170006834 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 509170006835 ATP-binding site [chemical binding]; other site 509170006836 Gluconate-6-phosphate binding site [chemical binding]; other site 509170006837 GntP family permease; Region: GntP_permease; pfam02447 509170006838 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 509170006839 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 509170006840 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509170006841 active site 509170006842 intersubunit interface [polypeptide binding]; other site 509170006843 catalytic residue [active] 509170006844 Dehydratase family; Region: ILVD_EDD; cl00340 509170006845 6-phosphogluconate dehydratase; Region: edd; TIGR01196 509170006846 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170006847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170006848 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of phosphate acetyltransferase (partial) 509170006849 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 509170006850 Fumarase C-terminus; Region: Fumerase_C; cl00795 509170006851 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 509170006852 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 509170006853 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 509170006854 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 509170006855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170006856 Walker A motif; other site 509170006857 ATP binding site [chemical binding]; other site 509170006858 Walker B motif; other site 509170006859 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 509170006860 Clp protease; Region: CLP_protease; pfam00574 509170006861 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 509170006862 oligomer interface [polypeptide binding]; other site 509170006863 active site residues [active] 509170006864 trigger factor; Provisional; Region: tig; PRK01490 509170006865 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509170006866 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 509170006867 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 509170006868 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 509170006869 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 509170006870 ligand-binding site [chemical binding]; other site 509170006871 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 509170006872 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 509170006873 2-isopropylmalate synthase; Validated; Region: PRK03739 509170006874 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 509170006875 active site 509170006876 catalytic residues [active] 509170006877 metal binding site [ion binding]; metal-binding site 509170006878 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 509170006879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170006880 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 509170006881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170006882 S-adenosylmethionine binding site [chemical binding]; other site 509170006883 Sel1 repeat; Region: Sel1; cl02723 509170006884 Sel1 repeat; Region: Sel1; cl02723 509170006885 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 509170006886 active site 509170006887 dimerization interface [polypeptide binding]; other site 509170006888 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006889 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006890 Membrane transport protein; Region: Mem_trans; cl09117 509170006891 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 509170006892 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 509170006893 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 509170006894 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 509170006895 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006896 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170006897 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 509170006898 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 509170006899 NRDE protein; Region: NRDE; cl01315 509170006900 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 509170006901 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 509170006902 dimerization interface [polypeptide binding]; other site 509170006903 active site 509170006904 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 509170006905 folate binding site [chemical binding]; other site 509170006906 NADP+ binding site [chemical binding]; other site 509170006907 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 509170006908 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 509170006909 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 509170006910 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 509170006911 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509170006912 Gram-negative bacterial tonB protein; Region: TonB; cl10048 509170006913 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 509170006914 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 509170006915 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 509170006916 putative active site [active] 509170006917 putative substrate binding site [chemical binding]; other site 509170006918 putative cosubstrate binding site; other site 509170006919 catalytic site [active] 509170006920 Helix-turn-helix domains; Region: HTH; cl00088 509170006921 Bacterial transcriptional repressor; Region: TetR; pfam13972 509170006922 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 509170006923 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 509170006924 NAD(P) binding site [chemical binding]; other site 509170006925 catalytic residues [active] 509170006926 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 509170006927 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 509170006928 putative cation:proton antiport protein; Provisional; Region: PRK10669 509170006929 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 509170006930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006931 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006932 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 509170006933 RNA/DNA binding site [nucleotide binding]; other site 509170006934 RRM dimerization site [polypeptide binding]; other site 509170006935 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 509170006936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170006937 Family description; Region: UvrD_C_2; cl15862 509170006938 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 509170006939 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; signal peptide 509170006940 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 509170006941 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 509170006942 active site 509170006943 interdomain interaction site; other site 509170006944 putative metal-binding site [ion binding]; other site 509170006945 nucleotide binding site [chemical binding]; other site 509170006946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 509170006947 domain I; other site 509170006948 DNA binding groove [nucleotide binding] 509170006949 phosphate binding site [ion binding]; other site 509170006950 domain II; other site 509170006951 domain III; other site 509170006952 nucleotide binding site [chemical binding]; other site 509170006953 catalytic site [active] 509170006954 domain IV; other site 509170006955 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 509170006956 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 509170006957 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 509170006958 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 509170006959 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170006960 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 509170006961 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 509170006962 putative NAD(P) binding site [chemical binding]; other site 509170006963 dimer interface [polypeptide binding]; other site 509170006964 SlyX; Region: SlyX; cl01090 509170006965 ABC transporter ATPase component; Reviewed; Region: PRK11147 509170006966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170006967 Walker A/P-loop; other site 509170006968 ATP binding site [chemical binding]; other site 509170006969 Q-loop/lid; other site 509170006970 ABC transporter signature motif; other site 509170006971 Walker B; other site 509170006972 D-loop; other site 509170006973 H-loop/switch region; other site 509170006974 ABC transporter; Region: ABC_tran_2; pfam12848 509170006975 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 509170006976 LysE type translocator; Region: LysE; cl00565 509170006977 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 509170006978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 509170006979 putative acyl-acceptor binding pocket; other site 509170006980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509170006981 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 509170006982 putative ADP-binding pocket [chemical binding]; other site 509170006983 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 509170006984 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 509170006985 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 509170006986 putative catalytic site [active] 509170006987 putative metal binding site [ion binding]; other site 509170006988 putative phosphate binding site [ion binding]; other site 509170006989 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 509170006990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170006991 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 509170006992 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 509170006993 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170006994 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170006995 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 509170006996 active site 509170006997 homodimer interface [polypeptide binding]; other site 509170006998 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 509170006999 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 509170007000 dimerization interface 3.5A [polypeptide binding]; other site 509170007001 active site 509170007002 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 509170007003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170007004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170007005 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 509170007006 rRNA binding site [nucleotide binding]; other site 509170007007 predicted 30S ribosome binding site; other site 509170007008 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 509170007009 tartrate dehydrogenase; Provisional; Region: PRK08194 509170007010 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 509170007011 substrate binding site [chemical binding]; other site 509170007012 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 509170007013 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 509170007014 substrate binding site [chemical binding]; other site 509170007015 ligand binding site [chemical binding]; other site 509170007016 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170007018 Helix-turn-helix domains; Region: HTH; cl00088 509170007019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509170007020 dimerization interface [polypeptide binding]; other site 509170007021 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 509170007022 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 509170007023 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 509170007024 putative active site [active] 509170007025 Ap4A binding site [chemical binding]; other site 509170007026 nudix motif; other site 509170007027 putative metal binding site [ion binding]; other site 509170007028 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 509170007029 GAF domain; Region: GAF; cl15785 509170007030 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509170007031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 509170007032 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 509170007033 Transposase domain (DUF772); Region: DUF772; cl15789 509170007034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007035 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509170007038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170007039 motif II; other site 509170007040 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 509170007041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509170007042 RNA binding surface [nucleotide binding]; other site 509170007043 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 509170007044 active site 509170007045 ribonuclease E; Reviewed; Region: rne; PRK10811 509170007046 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 509170007047 homodimer interface [polypeptide binding]; other site 509170007048 oligonucleotide binding site [chemical binding]; other site 509170007049 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 509170007050 AMP-binding enzyme; Region: AMP-binding; cl15778 509170007051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170007052 Helix-turn-helix domains; Region: HTH; cl00088 509170007053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 509170007054 putative effector binding pocket; other site 509170007055 putative dimerization interface [polypeptide binding]; other site 509170007056 short chain dehydrogenase; Provisional; Region: PRK12744 509170007057 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 509170007058 NADP binding site [chemical binding]; other site 509170007059 homodimer interface [polypeptide binding]; other site 509170007060 active site 509170007061 substrate binding site [chemical binding]; other site 509170007062 HemN family oxidoreductase; Provisional; Region: PRK05660 509170007063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 509170007064 FeS/SAM binding site; other site 509170007065 HemN C-terminal domain; Region: HemN_C; pfam06969 509170007066 Protein of unknown function, DUF606; Region: DUF606; cl01273 509170007067 multidrug efflux protein; Reviewed; Region: PRK01766 509170007068 MatE; Region: MatE; cl10513 509170007069 MatE; Region: MatE; cl10513 509170007070 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170007071 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170007072 Flavin binding site [chemical binding]; other site 509170007073 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 509170007074 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 509170007075 Flavin binding site [chemical binding]; other site 509170007076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170007077 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 509170007078 HopJ type III effector protein; Region: HopJ; pfam08888 509170007079 CrcB-like protein; Region: CRCB; cl09114 509170007080 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170007081 Predicted flavoproteins [General function prediction only]; Region: COG2081 509170007082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 509170007085 Domain of unknown function (DUF329); Region: DUF329; cl01144 509170007086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170007087 ferrochelatase; Reviewed; Region: hemH; PRK00035 509170007088 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 509170007089 C-terminal domain interface [polypeptide binding]; other site 509170007090 active site 509170007091 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 509170007092 active site 509170007093 N-terminal domain interface [polypeptide binding]; other site 509170007094 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007095 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007096 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509170007097 aspartate racemase; Region: asp_race; TIGR00035 509170007098 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 509170007099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007100 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 509170007101 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 509170007102 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509170007103 Transposase domain (DUF772); Region: DUF772; cl15789 509170007104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007105 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007106 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 509170007107 CPxP motif; other site 509170007108 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 509170007109 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 509170007110 Transporter associated domain; Region: CorC_HlyC; cl08393 509170007111 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 509170007112 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 509170007113 putative active site [active] 509170007114 catalytic triad [active] 509170007115 putative dimer interface [polypeptide binding]; other site 509170007116 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 509170007117 dimer interface [polypeptide binding]; other site 509170007118 putative tRNA-binding site [nucleotide binding]; other site 509170007119 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007121 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 509170007122 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 509170007123 general secretion pathway protein F; Region: GspF; TIGR02120 509170007124 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 509170007125 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 509170007126 primosome assembly protein PriA; Validated; Region: PRK05580 509170007127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509170007128 ATP binding site [chemical binding]; other site 509170007129 putative Mg++ binding site [ion binding]; other site 509170007130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007131 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 509170007132 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 509170007133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007134 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 509170007135 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 509170007136 dimerization interface [polypeptide binding]; other site 509170007137 domain crossover interface; other site 509170007138 redox-dependent activation switch; other site 509170007139 LysE type translocator; Region: LysE; cl00565 509170007140 Evidence 7 : Gene remnant; Product type f : factor; fragment of curved DNA-binding protein (part 1) 509170007141 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007143 Evidence 7 : Gene remnant; Product type f : factor; fragment of curved DNA-binding protein (part 2) 509170007144 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 509170007145 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 509170007146 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 509170007147 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 509170007148 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 509170007149 RNase E interface [polypeptide binding]; other site 509170007150 trimer interface [polypeptide binding]; other site 509170007151 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 509170007152 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 509170007153 RNase E interface [polypeptide binding]; other site 509170007154 trimer interface [polypeptide binding]; other site 509170007155 active site 509170007156 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 509170007157 putative nucleic acid binding region [nucleotide binding]; other site 509170007158 G-X-X-G motif; other site 509170007159 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 509170007160 RNA binding site [nucleotide binding]; other site 509170007161 domain interface; other site 509170007162 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 509170007163 16S/18S rRNA binding site [nucleotide binding]; other site 509170007164 S13e-L30e interaction site [polypeptide binding]; other site 509170007165 25S rRNA binding site [nucleotide binding]; other site 509170007166 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 509170007167 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170007168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007169 AAA domain; Region: AAA_22; pfam13401 509170007170 Family description; Region: UvrD_C_2; cl15862 509170007171 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 509170007172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007173 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 509170007174 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509170007175 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 509170007176 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 509170007177 Domain of unknown function (DUF697); Region: DUF697; cl12064 509170007178 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 509170007179 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 509170007180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007181 active site 509170007182 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 509170007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170007184 S-adenosylmethionine binding site [chemical binding]; other site 509170007185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 509170007187 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 509170007188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170007189 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase; flavoprotein monooxygenase (part 1) 509170007190 Transposase domain (DUF772); Region: DUF772; cl15789 509170007191 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007192 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of oxidoreductase; flavoprotein monooxygenase (part 2) 509170007193 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 509170007194 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 509170007195 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509170007196 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 509170007197 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 509170007198 Family description; Region: UvrD_C_2; cl15862 509170007199 AAA domain; Region: AAA_23; pfam13476 509170007200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007201 ABC transporter signature motif; other site 509170007202 Walker B; other site 509170007203 D-loop; other site 509170007204 MutS2 family protein; Region: mutS2; TIGR01069 509170007205 H-loop/switch region; other site 509170007206 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 509170007207 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509170007208 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 509170007209 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 509170007210 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 509170007211 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 509170007212 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 509170007213 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509170007214 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 509170007215 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 509170007216 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 509170007217 Ribosome-binding factor A; Region: RBFA; cl00542 509170007218 translation initiation factor IF-2; Validated; Region: infB; PRK05306 509170007219 translation initiation factor IF-2; Validated; Region: infB; PRK05306 509170007220 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 509170007221 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 509170007222 G1 box; other site 509170007223 putative GEF interaction site [polypeptide binding]; other site 509170007224 GTP/Mg2+ binding site [chemical binding]; other site 509170007225 Switch I region; other site 509170007226 G2 box; other site 509170007227 G3 box; other site 509170007228 Switch II region; other site 509170007229 G4 box; other site 509170007230 G5 box; other site 509170007231 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 509170007232 Translation-initiation factor 2; Region: IF-2; pfam11987 509170007233 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 509170007234 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 509170007235 NusA N-terminal domain; Region: NusA_N; pfam08529 509170007236 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 509170007237 RNA binding site [nucleotide binding]; other site 509170007238 homodimer interface [polypeptide binding]; other site 509170007239 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 509170007240 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 509170007241 G-X-X-G motif; other site 509170007242 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 509170007243 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 509170007244 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 509170007245 ribosome maturation protein RimP; Reviewed; Region: PRK00092 509170007246 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 509170007247 Sm1 motif; other site 509170007248 D3 - B interaction site; other site 509170007249 D1 - D2 interaction site; other site 509170007250 Hfq - Hfq interaction site; other site 509170007251 RNA binding pocket [nucleotide binding]; other site 509170007252 Sm2 motif; other site 509170007253 Preprotein translocase SecG subunit; Region: SecG; cl09123 509170007254 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 509170007255 substrate binding site [chemical binding]; other site 509170007256 dimer interface [polypeptide binding]; other site 509170007257 catalytic triad [active] 509170007258 Evidence 7 : Gene remnant; Product type t : transporter; fragment of type 4 fimbrial biogenesis protein (part 1) 509170007259 Transposase domain (DUF772); Region: DUF772; cl15789 509170007260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007261 Evidence 7 : Gene remnant; Product type t : transporter; fragment of type 4 fimbrial biogenesis protein (part 2) 509170007262 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial assembly protein (part 1) 509170007263 Evidence 7 : Gene remnant; Product type m : membrane component; fragment of type 4 fimbrial assembly protein (part 2) 509170007264 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 509170007265 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 509170007266 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 509170007267 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 509170007268 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 509170007269 CoA-binding site [chemical binding]; other site 509170007270 ATP-binding [chemical binding]; other site 509170007271 EamA-like transporter family; Region: EamA; cl01037 509170007272 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 509170007273 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 509170007274 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509170007275 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 509170007276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 509170007277 binding surface 509170007278 Tetratricopeptide repeat; Region: TPR_16; pfam13432 509170007279 TPR motif; other site 509170007280 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 509170007281 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 509170007282 Walker A/P-loop; other site 509170007283 ATP binding site [chemical binding]; other site 509170007284 Q-loop/lid; other site 509170007285 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 509170007286 ABC transporter signature motif; other site 509170007287 Walker B; other site 509170007288 D-loop; other site 509170007289 H-loop/switch region; other site 509170007290 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 509170007291 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 509170007292 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 509170007293 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170007294 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170007295 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 509170007296 Fusaric acid resistance protein family; Region: FUSC; pfam04632 509170007297 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 509170007298 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509170007299 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170007300 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 509170007301 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator of DNA repair (AraC/Xyl family); O6-methylguanine-DNA methyltransferase] (part 2) 509170007302 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007303 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007304 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of bifunctional protein [Includes: transcriptional regulator of DNA repair (AraC/Xyl family); O6-methylguanine-DNA methyltransferase] (part 1) 509170007305 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509170007306 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 509170007307 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 509170007308 active site 509170007309 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 509170007310 active site 509170007311 dimer interface [polypeptide binding]; other site 509170007312 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 509170007313 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 509170007314 GIY-YIG motif/motif A; other site 509170007315 active site 509170007316 catalytic site [active] 509170007317 putative DNA binding site [nucleotide binding]; other site 509170007318 metal binding site [ion binding]; metal-binding site 509170007319 UvrB/uvrC motif; Region: UVR; pfam02151 509170007320 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 509170007321 Cupin domain; Region: Cupin_2; cl09118 509170007322 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 509170007323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 509170007324 substrate binding site [chemical binding]; other site 509170007325 oxyanion hole (OAH) forming residues; other site 509170007326 trimer interface [polypeptide binding]; other site 509170007327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007328 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 509170007329 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 509170007330 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 509170007331 dimer interface [polypeptide binding]; other site 509170007332 active site 509170007333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170007334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509170007335 Transposase domain (DUF772); Region: DUF772; cl15789 509170007336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007337 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007338 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007339 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007340 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007341 heat shock protein 90; Provisional; Region: PRK05218 509170007342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170007343 ATP binding site [chemical binding]; other site 509170007344 Mg2+ binding site [ion binding]; other site 509170007345 G-X-G motif; other site 509170007346 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 509170007347 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 509170007348 Predicted permease [General function prediction only]; Region: COG2056 509170007349 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 509170007350 short chain dehydrogenase; Validated; Region: PRK05855 509170007351 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 509170007352 CoenzymeA binding site [chemical binding]; other site 509170007353 subunit interaction site [polypeptide binding]; other site 509170007354 PHB binding site; other site 509170007355 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007356 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007357 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 509170007358 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 509170007359 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 509170007360 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 509170007361 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 509170007362 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 509170007363 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509170007364 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 509170007365 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 509170007366 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 509170007367 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 509170007368 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 509170007369 DNA binding site [nucleotide binding] 509170007370 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 509170007371 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 509170007372 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 509170007373 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509170007374 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 509170007375 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 509170007376 RPB11 interaction site [polypeptide binding]; other site 509170007377 RPB12 interaction site [polypeptide binding]; other site 509170007378 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509170007379 RPB1 interaction site [polypeptide binding]; other site 509170007380 RPB11 interaction site [polypeptide binding]; other site 509170007381 RPB10 interaction site [polypeptide binding]; other site 509170007382 RPB3 interaction site [polypeptide binding]; other site 509170007383 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 509170007384 core dimer interface [polypeptide binding]; other site 509170007385 peripheral dimer interface [polypeptide binding]; other site 509170007386 L10 interface [polypeptide binding]; other site 509170007387 L11 interface [polypeptide binding]; other site 509170007388 putative EF-Tu interaction site [polypeptide binding]; other site 509170007389 putative EF-G interaction site [polypeptide binding]; other site 509170007390 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 509170007391 23S rRNA interface [nucleotide binding]; other site 509170007392 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 509170007393 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 509170007394 mRNA/rRNA interface [nucleotide binding]; other site 509170007395 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 509170007396 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 509170007397 23S rRNA interface [nucleotide binding]; other site 509170007398 L7/L12 interface [polypeptide binding]; other site 509170007399 putative thiostrepton binding site; other site 509170007400 L25 interface [polypeptide binding]; other site 509170007401 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 509170007402 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 509170007403 putative homodimer interface [polypeptide binding]; other site 509170007404 KOW motif; Region: KOW; cl00354 509170007405 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 509170007406 elongation factor Tu; Reviewed; Region: PRK00049 509170007407 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 509170007408 G1 box; other site 509170007409 GEF interaction site [polypeptide binding]; other site 509170007410 GTP/Mg2+ binding site [chemical binding]; other site 509170007411 Switch I region; other site 509170007412 G2 box; other site 509170007413 G3 box; other site 509170007414 Switch II region; other site 509170007415 G4 box; other site 509170007416 G5 box; other site 509170007417 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509170007418 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 509170007419 Antibiotic Binding Site [chemical binding]; other site 509170007420 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of anthranilate synthase component I (part 2) 509170007421 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of anthranilate synthase component I (part 1) 509170007422 phosphoglycolate phosphatase; Provisional; Region: PRK13222 509170007423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170007424 motif II; other site 509170007425 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 509170007426 phosphopeptide binding site; other site 509170007427 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 509170007428 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007429 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007430 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 509170007431 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 509170007432 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 509170007433 general secretion pathway protein C; Region: typeII_sec_gspC; TIGR01713 509170007434 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 509170007435 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 509170007436 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 509170007437 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007438 Transposase domain (DUF772); Region: DUF772; cl15789 509170007439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007440 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 1) 509170007441 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509170007442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007443 active site 509170007444 phosphorylation site [posttranslational modification] 509170007445 intermolecular recognition site; other site 509170007446 dimerization interface [polypeptide binding]; other site 509170007447 LytTr DNA-binding domain; Region: LytTR; cl04498 509170007448 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 509170007449 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 509170007450 domain interfaces; other site 509170007451 active site 509170007452 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 509170007453 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 509170007454 active site 509170007455 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 509170007456 active site 509170007457 H-NS histone family; Region: Histone_HNS; pfam00816 509170007458 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 509170007459 Transposase domain (DUF772); Region: DUF772; cl15789 509170007460 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007461 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 2) 509170007462 Evidence 7 : Gene remnant; Product type r : regulator; fragment of alginate biosynthesis protein (part 1) 509170007463 argininosuccinate lyase; Provisional; Region: PRK00855 509170007464 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 509170007465 active sites [active] 509170007466 tetramer interface [polypeptide binding]; other site 509170007467 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 509170007468 transcriptional regulator PhoU; Provisional; Region: PRK11115 509170007469 PhoU domain; Region: PhoU; pfam01895 509170007470 PhoU domain; Region: PhoU; pfam01895 509170007471 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 509170007472 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007473 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007475 Helix-turn-helix domains; Region: HTH; cl00088 509170007476 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007477 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007478 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 509170007479 ThiC-associated domain; Region: ThiC-associated; pfam13667 509170007480 ThiC family; Region: ThiC; cl08031 509170007481 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 509170007482 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 509170007483 dimer interface [polypeptide binding]; other site 509170007484 ADP-ribose binding site [chemical binding]; other site 509170007485 active site 509170007486 nudix motif; other site 509170007487 metal binding site [ion binding]; metal-binding site 509170007488 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 509170007489 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509170007490 active site 509170007491 metal binding site [ion binding]; metal-binding site 509170007492 hexamer interface [polypeptide binding]; other site 509170007493 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 509170007494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509170007495 active site 509170007496 nucleotide binding site [chemical binding]; other site 509170007497 HIGH motif; other site 509170007498 KMSKS motif; other site 509170007499 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 509170007500 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 509170007501 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170007502 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170007503 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 509170007504 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 509170007505 G1 box; other site 509170007506 GTP/Mg2+ binding site [chemical binding]; other site 509170007507 Switch I region; other site 509170007508 G2 box; other site 509170007509 G3 box; other site 509170007510 Switch II region; other site 509170007511 G4 box; other site 509170007512 G5 box; other site 509170007513 Nucleoside recognition; Region: Gate; cl00486 509170007514 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 509170007515 Nucleoside recognition; Region: Gate; cl00486 509170007516 FeoA domain; Region: FeoA; cl00838 509170007517 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 509170007518 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 509170007519 Int/Topo IB signature motif; other site 509170007520 active site 509170007521 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509170007522 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170007523 dimerization domain [polypeptide binding]; other site 509170007524 dimer interface [polypeptide binding]; other site 509170007525 catalytic residues [active] 509170007526 homoserine dehydrogenase; Provisional; Region: PRK06349 509170007527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007528 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509170007529 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 509170007530 threonine synthase; Reviewed; Region: PRK06721 509170007531 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 509170007532 homodimer interface [polypeptide binding]; other site 509170007533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007534 catalytic residue [active] 509170007535 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 509170007536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 509170007537 response regulator; Provisional; Region: PRK09483 509170007538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007539 active site 509170007540 phosphorylation site [posttranslational modification] 509170007541 intermolecular recognition site; other site 509170007542 dimerization interface [polypeptide binding]; other site 509170007543 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509170007544 DNA binding residues [nucleotide binding] 509170007545 dimerization interface [polypeptide binding]; other site 509170007546 Evidence 7 : Gene remnant; Product type r : regulator; fragment of sensor protein (part 1) 509170007547 Evidence 7 : Gene remnant; Product type r : regulator; fragment of sensor protein (part 2) 509170007548 Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 1) 509170007549 Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 2) 509170007550 Transposase domain (DUF772); Region: DUF772; cl15789 509170007551 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007552 X;Evidence 7 : Gene remnant; Product type r : regulator; fragment of type 4 fimbriae expression regulatory protein (part 3) 509170007553 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 509170007554 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509170007555 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 509170007556 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509170007557 Catalytic dyad [active] 509170007558 Sulfatase; Region: Sulfatase; cl10460 509170007559 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 509170007560 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 509170007561 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509170007562 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 509170007563 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 509170007564 multifunctional aminopeptidase A; Provisional; Region: PRK00913 509170007565 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 509170007566 interface (dimer of trimers) [polypeptide binding]; other site 509170007567 Substrate-binding/catalytic site; other site 509170007568 Zn-binding sites [ion binding]; other site 509170007569 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 509170007570 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 509170007571 Lumazine binding domain; Region: Lum_binding; pfam00677 509170007572 Lumazine binding domain; Region: Lum_binding; pfam00677 509170007573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007574 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 509170007575 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 509170007576 catalytic motif [active] 509170007577 Zn binding site [ion binding]; other site 509170007578 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 509170007579 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 509170007580 ATP cone domain; Region: ATP-cone; pfam03477 509170007581 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 509170007582 Nitrogen regulatory protein P-II; Region: P-II; cl00412 509170007583 Nitrogen regulatory protein P-II; Region: P-II; smart00938 509170007584 Membrane fusogenic activity; Region: BMFP; cl01115 509170007585 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM) (partial) 509170007586 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 509170007587 active site 509170007588 8-oxo-dGMP binding site [chemical binding]; other site 509170007589 nudix motif; other site 509170007590 metal binding site [ion binding]; metal-binding site 509170007591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 509170007592 Domain of unknown function (DUF955); Region: DUF955; cl01076 509170007593 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 509170007594 dimerization interface [polypeptide binding]; other site 509170007595 active site 509170007596 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 509170007597 TniQ; Region: TniQ; pfam06527 509170007598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007599 AAA domain; Region: AAA_22; pfam13401 509170007600 Winged helix-turn helix; Region: HTH_29; pfam13551 509170007601 Integrase core domain; Region: rve; cl01316 509170007602 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 509170007603 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 509170007604 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 509170007605 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509170007606 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509170007607 glutamine binding [chemical binding]; other site 509170007608 catalytic triad [active] 509170007609 anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820 509170007610 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509170007611 chorismate binding enzyme; Region: Chorismate_bind; cl10555 509170007612 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007614 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007615 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007616 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 509170007617 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM) (partial) 509170007618 Transposase domain (DUF772); Region: DUF772; cl15789 509170007619 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007620 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 509170007621 amphipathic channel; other site 509170007622 Asn-Pro-Ala signature motifs; other site 509170007623 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007624 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007625 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007626 Transposase domain (DUF772); Region: DUF772; cl15789 509170007627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007628 LysE type translocator; Region: LysE; cl00565 509170007629 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 509170007630 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 509170007631 active site 509170007632 substrate binding site [chemical binding]; other site 509170007633 Mg2+ binding site [ion binding]; other site 509170007634 potassium uptake protein; Region: kup; TIGR00794 509170007635 K+ potassium transporter; Region: K_trans; cl15781 509170007636 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007637 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007638 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007639 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007640 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007641 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007642 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007643 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007644 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (TetR family) (partial) 509170007645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509170007646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509170007647 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 509170007648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170007649 active site 509170007650 catalytic tetrad [active] 509170007651 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007652 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007653 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509170007654 EamA-like transporter family; Region: EamA; cl01037 509170007655 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 509170007656 Helix-turn-helix domains; Region: HTH; cl00088 509170007657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170007658 dimerization interface [polypeptide binding]; other site 509170007659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170007660 putative substrate translocation pore; other site 509170007661 Transposase domain (DUF772); Region: DUF772; cl15789 509170007662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007663 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 509170007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170007665 S-adenosylmethionine binding site [chemical binding]; other site 509170007666 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 509170007667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007668 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007669 Transposase domain (DUF772); Region: DUF772; cl15789 509170007670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007671 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007672 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of transcriptional regulator (LysR family) (partial) 509170007673 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 509170007674 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 509170007675 tetramerization interface [polypeptide binding]; other site 509170007676 NAD(P) binding site [chemical binding]; other site 509170007677 catalytic residues [active] 509170007678 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 509170007679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 509170007680 inhibitor-cofactor binding pocket; inhibition site 509170007681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007682 catalytic residue [active] 509170007683 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509170007684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170007685 DNA-binding site [nucleotide binding]; DNA binding site 509170007686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170007687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170007688 homodimer interface [polypeptide binding]; other site 509170007689 catalytic residue [active] 509170007690 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 509170007691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509170007692 non-specific DNA binding site [nucleotide binding]; other site 509170007693 salt bridge; other site 509170007694 sequence-specific DNA binding site [nucleotide binding]; other site 509170007695 Cupin domain; Region: Cupin_2; cl09118 509170007696 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 1) 509170007697 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein (part 2) 509170007698 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 509170007699 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509170007700 dimer interface [polypeptide binding]; other site 509170007701 ssDNA binding site [nucleotide binding]; other site 509170007702 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509170007703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170007704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509170007705 putative substrate translocation pore; other site 509170007706 Integral membrane protein TerC family; Region: TerC; cl10468 509170007707 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007708 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007709 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007710 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007711 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 509170007712 GlpM protein; Region: GlpM; cl01212 509170007713 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 509170007714 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 509170007715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 509170007716 putative NAD(P) binding site [chemical binding]; other site 509170007717 putative dimer interface [polypeptide binding]; other site 509170007718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007719 Helix-turn-helix domains; Region: HTH; cl00088 509170007720 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 509170007721 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 509170007722 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 509170007723 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 509170007724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170007725 metal binding site [ion binding]; metal-binding site 509170007726 active site 509170007727 I-site; other site 509170007728 BCCT family transporter; Region: BCCT; cl00569 509170007729 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007730 Transposase domain (DUF772); Region: DUF772; cl15789 509170007731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 509170007733 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 509170007734 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509170007735 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 509170007736 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 509170007737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170007738 ATP binding site [chemical binding]; other site 509170007739 putative Mg++ binding site [ion binding]; other site 509170007740 Abi-like protein; Region: Abi_2; cl01988 509170007741 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 509170007742 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170007743 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 509170007744 HsdM N-terminal domain; Region: HsdM_N; pfam12161 509170007745 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007746 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007747 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007748 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007749 PAAR motif; Region: PAAR_motif; cl15808 509170007750 PAAR motif; Region: PAAR_motif; cl15808 509170007751 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007752 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007753 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007754 Sodium:solute symporter family; Region: SSF; cl00456 509170007755 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 509170007756 Protein of unknown function, DUF485; Region: DUF485; cl01231 509170007757 Sodium:solute symporter family; Region: SSF; cl00456 509170007758 PAS fold; Region: PAS_7; pfam12860 509170007759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170007760 dimer interface [polypeptide binding]; other site 509170007761 phosphorylation site [posttranslational modification] 509170007762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170007763 ATP binding site [chemical binding]; other site 509170007764 Mg2+ binding site [ion binding]; other site 509170007765 G-X-G motif; other site 509170007766 Response regulator receiver domain; Region: Response_reg; pfam00072 509170007767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007768 active site 509170007769 phosphorylation site [posttranslational modification] 509170007770 intermolecular recognition site; other site 509170007771 dimerization interface [polypeptide binding]; other site 509170007772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509170007773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007774 active site 509170007775 phosphorylation site [posttranslational modification] 509170007776 intermolecular recognition site; other site 509170007777 dimerization interface [polypeptide binding]; other site 509170007778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 509170007779 DNA binding residues [nucleotide binding] 509170007780 dimerization interface [polypeptide binding]; other site 509170007781 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509170007782 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 509170007783 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 509170007784 active site 509170007785 dimer interface [polypeptide binding]; other site 509170007786 non-prolyl cis peptide bond; other site 509170007787 insertion regions; other site 509170007788 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007790 Helix-turn-helix domains; Region: HTH; cl00088 509170007791 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of isochorismatase (partial) 509170007792 acetyl-CoA synthetase; Provisional; Region: PRK00174 509170007793 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 509170007794 AMP-binding enzyme; Region: AMP-binding; cl15778 509170007795 AMP-binding enzyme; Region: AMP-binding; cl15778 509170007796 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509170007797 Protein of unknown function (DUF805); Region: DUF805; cl01224 509170007798 OpgC protein; Region: OpgC_C; cl00792 509170007799 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509170007800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 509170007801 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 509170007802 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 509170007803 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 509170007804 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509170007805 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 509170007806 FMN binding site [chemical binding]; other site 509170007807 active site 509170007808 substrate binding site [chemical binding]; other site 509170007809 catalytic residue [active] 509170007810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509170007811 putative DNA binding site [nucleotide binding]; other site 509170007812 dimerization interface [polypeptide binding]; other site 509170007813 putative Zn2+ binding site [ion binding]; other site 509170007814 peptide chain release factor 2; Provisional; Region: PRK08787 509170007815 RF-1 domain; Region: RF-1; cl02875 509170007816 RF-1 domain; Region: RF-1; cl02875 509170007817 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 509170007818 DHH family; Region: DHH; pfam01368 509170007819 DHHA1 domain; Region: DHHA1; pfam02272 509170007820 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 509170007821 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 509170007822 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 509170007823 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 509170007824 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 509170007825 active site 509170007826 substrate binding site [chemical binding]; other site 509170007827 metal binding site [ion binding]; metal-binding site 509170007828 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 509170007829 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509170007830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 509170007831 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 509170007832 active site 509170007833 Flagellin N-methylase; Region: FliB; cl00497 509170007834 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509170007835 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 1) 509170007836 Transposase domain (DUF772); Region: DUF772; cl15789 509170007837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007838 Evidence 7 : Gene remnant; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 2) 509170007839 Predicted membrane protein [Function unknown]; Region: COG2119 509170007840 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509170007841 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509170007842 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007843 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170007844 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170007845 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 509170007846 E3 interaction surface; other site 509170007847 lipoyl attachment site [posttranslational modification]; other site 509170007848 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509170007849 E3 interaction surface; other site 509170007850 lipoyl attachment site [posttranslational modification]; other site 509170007851 e3 binding domain; Region: E3_binding; pfam02817 509170007852 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 509170007853 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 509170007854 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 509170007855 dimer interface [polypeptide binding]; other site 509170007856 TPP-binding site [chemical binding]; other site 509170007857 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 509170007858 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170007859 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 509170007860 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 509170007861 cell division protein FtsZ; Validated; Region: PRK09330 509170007862 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 509170007863 nucleotide binding site [chemical binding]; other site 509170007864 SulA interaction site; other site 509170007865 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 509170007866 Cell division protein FtsA; Region: FtsA; cl11496 509170007867 Cell division protein FtsA; Region: FtsA; cl11496 509170007868 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 509170007869 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 509170007870 Cell division protein FtsQ; Region: FtsQ; pfam03799 509170007871 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 509170007872 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 509170007873 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170007874 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 509170007875 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170007876 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170007877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170007878 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 509170007879 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 509170007880 active site 509170007881 homodimer interface [polypeptide binding]; other site 509170007882 glutathione synthetase; Provisional; Region: PRK05246 509170007883 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 509170007884 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170007885 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 509170007886 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007887 Mor transcription activator family; Region: Mor; cl02360 509170007888 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 1) 509170007889 Transposase domain (DUF772); Region: DUF772; cl15789 509170007890 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007891 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; fragment of ferric siderophore receptor protein (part 2) 509170007892 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 509170007893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170007894 active site 509170007895 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 509170007896 putative active site [active] 509170007897 putative DNA binding site [nucleotide binding]; other site 509170007898 putative phosphate binding site [ion binding]; other site 509170007899 putative catalytic site [active] 509170007900 metal binding site A [ion binding]; metal-binding site 509170007901 putative AP binding site [nucleotide binding]; other site 509170007902 putative metal binding site B [ion binding]; other site 509170007903 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 509170007904 ArsC family; Region: ArsC; pfam03960 509170007905 putative catalytic residues [active] 509170007906 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 509170007907 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170007908 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 509170007909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509170007910 metal binding site [ion binding]; metal-binding site 509170007911 active site 509170007912 I-site; other site 509170007913 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 509170007914 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 509170007915 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 509170007916 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 509170007917 DsbD alpha interface [polypeptide binding]; other site 509170007918 catalytic residues [active] 509170007919 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 509170007920 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170007921 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 509170007922 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 509170007923 30S subunit binding site; other site 509170007924 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 509170007925 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 509170007926 active site 509170007927 catalytic site [active] 509170007928 tetramer interface [polypeptide binding]; other site 509170007929 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 509170007930 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 509170007931 active site 509170007932 homotetramer interface [polypeptide binding]; other site 509170007933 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 509170007934 xanthine permease; Region: pbuX; TIGR03173 509170007935 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170007936 Transposase domain (DUF772); Region: DUF772; cl15789 509170007937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007938 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170007939 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170007940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007942 FAD binding domain; Region: FAD_binding_3; pfam01494 509170007943 allantoicase; Provisional; Region: PRK13257 509170007944 Allantoicase repeat; Region: Allantoicase; pfam03561 509170007945 Allantoicase repeat; Region: Allantoicase; pfam03561 509170007946 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 509170007947 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 509170007948 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 509170007949 classical (c) SDRs; Region: SDR_c; cd05233 509170007950 NAD(P) binding site [chemical binding]; other site 509170007951 active site 509170007952 Transposase domain (DUF772); Region: DUF772; cl15789 509170007953 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007954 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 509170007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170007956 ATP binding site [chemical binding]; other site 509170007957 Mg2+ binding site [ion binding]; other site 509170007958 G-X-G motif; other site 509170007959 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 509170007960 anchoring element; other site 509170007961 dimer interface [polypeptide binding]; other site 509170007962 ATP binding site [chemical binding]; other site 509170007963 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 509170007964 active site 509170007965 metal binding site [ion binding]; metal-binding site 509170007966 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509170007967 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 509170007968 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170007969 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509170007970 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007971 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007972 Transposase domain (DUF772); Region: DUF772; cl15789 509170007973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170007974 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba7, IS5 family 509170007975 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial) 509170007976 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 509170007977 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 509170007978 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 509170007979 Protein of unknown function (DUF445); Region: DUF445; pfam04286 509170007980 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 1) 509170007981 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of aminotransferase (part 2) 509170007982 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 509170007983 MatE; Region: MatE; cl10513 509170007984 MatE; Region: MatE; cl10513 509170007985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170007986 short chain dehydrogenase; Provisional; Region: PRK07832 509170007987 NAD(P) binding site [chemical binding]; other site 509170007988 active site 509170007989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170007990 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 509170007991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 509170007992 active site 509170007993 phosphorylation site [posttranslational modification] 509170007994 intermolecular recognition site; other site 509170007995 dimerization interface [polypeptide binding]; other site 509170007996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 509170007997 DNA binding site [nucleotide binding] 509170007998 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 509170007999 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509170008000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509170008001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 509170008002 dimer interface [polypeptide binding]; other site 509170008003 phosphorylation site [posttranslational modification] 509170008004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509170008005 ATP binding site [chemical binding]; other site 509170008006 Mg2+ binding site [ion binding]; other site 509170008007 G-X-G motif; other site 509170008008 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; secretory lipase precursor (part 2) 509170008009 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; secretory lipase precursor (part 1) 509170008010 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 509170008011 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 509170008012 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 509170008013 active site residue [active] 509170008014 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 509170008015 active site residue [active] 509170008016 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 509170008017 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 509170008018 active site 509170008019 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 509170008020 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 509170008021 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 509170008022 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 509170008023 tetramer interface [polypeptide binding]; other site 509170008024 heme binding pocket [chemical binding]; other site 509170008025 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 509170008026 putative active site [active] 509170008027 dimerization interface [polypeptide binding]; other site 509170008028 putative tRNAtyr binding site [nucleotide binding]; other site 509170008029 Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase of ISAba6, IS982 family 509170008030 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008032 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of hydrolase (partial) 509170008033 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509170008034 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 509170008035 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 509170008036 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 509170008037 multiple promoter invertase; Provisional; Region: mpi; PRK13413 509170008038 catalytic residues [active] 509170008039 catalytic nucleophile [active] 509170008040 Helix-turn-helix domains; Region: HTH; cl00088 509170008041 Putative phage integrase; Region: Phage_Integr_2; pfam13009 509170008042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509170008043 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 509170008044 DNA binding site [nucleotide binding] 509170008045 active site 509170008046 Int/Topo IB signature motif; other site 509170008047 catalytic residues [active] 509170008048 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 509170008049 AAA domain; Region: AAA_21; pfam13304 509170008050 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 509170008051 ABC transporter signature motif; other site 509170008052 Walker B; other site 509170008053 D-loop; other site 509170008054 H-loop/switch region; other site 509170008055 haemagglutination activity domain; Region: Haemagg_act; cl05436 509170008056 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 509170008057 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 509170008058 RTX toxin acyltransferase family; Region: HlyC; cl01131 509170008059 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 509170008060 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 509170008061 Surface antigen; Region: Bac_surface_Ag; cl03097 509170008062 Helix-turn-helix domains; Region: HTH; cl00088 509170008063 Integrase core domain; Region: rve; cl01316 509170008064 transposase/IS protein; Provisional; Region: PRK09183 509170008065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 509170008066 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 509170008067 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170008068 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 509170008069 HsdM N-terminal domain; Region: HsdM_N; pfam12161 509170008070 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 509170008071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170008072 AAA domain; Region: AAA_22; pfam13401 509170008073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170008074 Walker A motif; other site 509170008075 ATP binding site [chemical binding]; other site 509170008076 Walker B motif; other site 509170008077 Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426 509170008078 Integrase core domain; Region: rve; cl01316 509170008079 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 509170008080 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 509170008081 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 509170008082 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 509170008083 glutaminase active site [active] 509170008084 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 509170008085 dimer interface [polypeptide binding]; other site 509170008086 active site 509170008087 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 509170008088 dimer interface [polypeptide binding]; other site 509170008089 active site 509170008090 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 509170008091 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 509170008092 Substrate binding site; other site 509170008093 Mg++ binding site; other site 509170008094 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 509170008095 active site 509170008096 substrate binding site [chemical binding]; other site 509170008097 CoA binding site [chemical binding]; other site 509170008098 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 509170008099 tetramer interfaces [polypeptide binding]; other site 509170008100 binuclear metal-binding site [ion binding]; other site 509170008101 thiamine monophosphate kinase; Provisional; Region: PRK05731 509170008102 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 509170008103 ATP binding site [chemical binding]; other site 509170008104 dimerization interface [polypeptide binding]; other site 509170008105 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 509170008106 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 509170008107 homopentamer interface [polypeptide binding]; other site 509170008108 active site 509170008109 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 509170008110 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 509170008111 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 509170008112 dimerization interface [polypeptide binding]; other site 509170008113 active site 509170008114 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 509170008115 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 509170008116 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 509170008117 phosphoserine phosphatase SerB; Region: serB; TIGR00338 509170008118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 509170008119 motif II; other site 509170008120 Transposase domain (DUF772); Region: DUF772; cl15789 509170008121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008122 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 509170008123 Arginase family; Region: Arginase; cl00306 509170008124 imidazolonepropionase; Validated; Region: PRK09356 509170008125 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 509170008126 active site 509170008127 putative proline-specific permease; Provisional; Region: proY; PRK10580 509170008128 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 509170008129 active sites [active] 509170008130 tetramer interface [polypeptide binding]; other site 509170008131 urocanate hydratase; Provisional; Region: PRK05414 509170008132 HutD; Region: HutD; cl01532 509170008133 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 509170008134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170008135 DNA-binding site [nucleotide binding]; DNA binding site 509170008136 UTRA domain; Region: UTRA; cl01230 509170008137 OpgC protein; Region: OpgC_C; cl00792 509170008138 Acyltransferase family; Region: Acyl_transf_3; pfam01757 509170008139 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of regulatory protein (nitrile hydratase activator like) (part 2) 509170008140 Transposase domain (DUF772); Region: DUF772; cl15789 509170008141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008142 Evidence 7 : Gene remnant; Product type pr : regulator; fragment of regulatory protein (nitrile hydratase activator like) (part 1) 509170008143 Peptidase M15; Region: Peptidase_M15_3; cl01194 509170008144 aromatic amino acid transporter; Provisional; Region: PRK10238 509170008145 Spore germination protein; Region: Spore_permease; cl15802 509170008146 fumarylacetoacetase; Region: PLN02856 509170008147 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 509170008148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509170008149 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 509170008150 maleylacetoacetate isomerase; Region: maiA; TIGR01262 509170008151 C-terminal domain interface [polypeptide binding]; other site 509170008152 GSH binding site (G-site) [chemical binding]; other site 509170008153 putative dimer interface [polypeptide binding]; other site 509170008154 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 509170008155 dimer interface [polypeptide binding]; other site 509170008156 N-terminal domain interface [polypeptide binding]; other site 509170008157 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 509170008158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 509170008159 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 509170008160 Zn binding site [ion binding]; other site 509170008161 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509170008162 Helix-turn-helix domains; Region: HTH; cl00088 509170008163 Bacterial transcriptional regulator; Region: IclR; pfam01614 509170008164 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 509170008165 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 509170008166 dimer interface [polypeptide binding]; other site 509170008167 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 509170008168 active site 509170008169 Fe binding site [ion binding]; other site 509170008170 Protein of unknown function (DUF523); Region: DUF523; cl00733 509170008171 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug resistance transporter (part 2) 509170008172 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of multidrug resistance transporter (part 1) 509170008173 Transposase domain (DUF772); Region: DUF772; cl15789 509170008174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008175 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008176 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008177 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 509170008178 Membrane transport protein; Region: Mem_trans; cl09117 509170008179 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 509170008180 Isochorismatase family; Region: Isochorismatase; pfam00857 509170008181 catalytic triad [active] 509170008182 metal binding site [ion binding]; metal-binding site 509170008183 conserved cis-peptide bond; other site 509170008184 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 509170008185 dihydrodipicolinate synthase; Region: dapA; TIGR00674 509170008186 dimer interface [polypeptide binding]; other site 509170008187 active site 509170008188 catalytic residue [active] 509170008189 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 509170008190 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 509170008191 ATP binding site [chemical binding]; other site 509170008192 active site 509170008193 substrate binding site [chemical binding]; other site 509170008194 Transposase domain (DUF772); Region: DUF772; cl15789 509170008195 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008196 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (formate/nitrite transporter family) (part 1) 509170008197 Evidence 7 : Gene remnant; Product type pt : transporter; fragment of transporter (formate/nitrite transporter family) (part 2) 509170008198 recombination factor protein RarA; Reviewed; Region: PRK13342 509170008199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 509170008200 Walker A motif; other site 509170008201 ATP binding site [chemical binding]; other site 509170008202 Walker B motif; other site 509170008203 arginine finger; other site 509170008204 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 509170008205 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 509170008206 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 509170008207 Flagellin N-methylase; Region: FliB; cl00497 509170008208 Transposase domain (DUF772); Region: DUF772; cl15789 509170008209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008210 hypothetical protein; Provisional; Region: PRK13682 509170008211 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 509170008212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509170008213 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 509170008214 nucleotide binding site/active site [active] 509170008215 HIT family signature motif; other site 509170008216 catalytic residue [active] 509170008217 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 509170008218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509170008219 minor groove reading motif; other site 509170008220 helix-hairpin-helix signature motif; other site 509170008221 substrate binding pocket [chemical binding]; other site 509170008222 active site 509170008223 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 509170008224 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 509170008225 DNA binding and oxoG recognition site [nucleotide binding] 509170008226 Peptidase family M23; Region: Peptidase_M23; pfam01551 509170008227 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 509170008228 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 509170008229 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 509170008230 putative NAD(P) binding site [chemical binding]; other site 509170008231 putative substrate binding site [chemical binding]; other site 509170008232 catalytic Zn binding site [ion binding]; other site 509170008233 structural Zn binding site [ion binding]; other site 509170008234 dimer interface [polypeptide binding]; other site 509170008235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509170008236 DNA-binding site [nucleotide binding]; DNA binding site 509170008237 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 509170008238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509170008239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509170008240 homodimer interface [polypeptide binding]; other site 509170008241 catalytic residue [active] 509170008242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170008243 Helix-turn-helix domains; Region: HTH; cl00088 509170008244 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 509170008245 putative effector binding pocket; other site 509170008246 dimerization interface [polypeptide binding]; other site 509170008247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 509170008248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509170008249 active site 509170008250 catalytic tetrad [active] 509170008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509170008252 putative substrate translocation pore; other site 509170008253 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 509170008254 putative lipid binding site [chemical binding]; other site 509170008255 dihydrodipicolinate reductase; Provisional; Region: PRK00048 509170008256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509170008257 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 509170008258 chaperone protein DnaJ; Provisional; Region: PRK10767 509170008259 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 509170008260 HSP70 interaction site [polypeptide binding]; other site 509170008261 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 509170008262 substrate binding site [polypeptide binding]; other site 509170008263 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 509170008264 Zn binding sites [ion binding]; other site 509170008265 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 509170008266 dimer interface [polypeptide binding]; other site 509170008267 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 509170008268 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509170008269 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 509170008270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509170008271 Helix-turn-helix domains; Region: HTH; cl00088 509170008272 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 509170008273 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 509170008274 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 509170008275 Transposase domain (DUF772); Region: DUF772; cl15789 509170008276 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008277 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 509170008278 uracil-xanthine permease; Region: ncs2; TIGR00801 509170008279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509170008280 Helix-turn-helix domains; Region: HTH; cl00088 509170008281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509170008282 dimerization interface [polypeptide binding]; other site 509170008283 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509170008284 Dehydratase family; Region: ILVD_EDD; cl00340 509170008285 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 509170008286 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 509170008287 putative active site [active] 509170008288 substrate binding site [chemical binding]; other site 509170008289 putative cosubstrate binding site; other site 509170008290 catalytic site [active] 509170008291 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 509170008292 substrate binding site [chemical binding]; other site 509170008293 16S rRNA methyltransferase B; Provisional; Region: PRK10901 509170008294 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 509170008295 putative RNA binding site [nucleotide binding]; other site 509170008296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 509170008297 S-adenosylmethionine binding site [chemical binding]; other site 509170008298 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 509170008299 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008300 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008301 Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of glutathione S-transferase (partial) 509170008302 Transposase domain (DUF772); Region: DUF772; cl15789 509170008303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008304 Transglycosylase SLT domain; Region: SLT_2; pfam13406 509170008305 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 509170008306 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 509170008307 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 509170008308 ATP-grasp domain; Region: ATP-grasp_4; cl03087 509170008309 AIR carboxylase; Region: AIRC; cl00310 509170008310 Transposase domain (DUF772); Region: DUF772; cl15789 509170008311 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008312 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2) 509170008313 Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1) 509170008314 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 509170008315 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509170008316 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509170008317 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509170008318 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 509170008319 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 509170008320 active site 509170008321 Integral membrane protein TerC family; Region: TerC; cl10468 509170008322 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 509170008323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509170008324 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 509170008325 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 509170008326 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 509170008327 [2Fe-2S] cluster binding site [ion binding]; other site 509170008328 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 509170008329 hydrophobic ligand binding site; other site 509170008330 guanine deaminase; Provisional; Region: PRK09228 509170008331 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 509170008332 active site 509170008333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 509170008334 active site 509170008335 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 509170008336 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 509170008337 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 509170008338 dimerization domain [polypeptide binding]; other site 509170008339 dimer interface [polypeptide binding]; other site 509170008340 catalytic residues [active] 509170008341 Cation efflux family; Region: Cation_efflux; cl00316 509170008342 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 509170008343 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 509170008344 putative metal binding site [ion binding]; other site 509170008345 putative homotetramer interface [polypeptide binding]; other site 509170008346 putative homodimer interface [polypeptide binding]; other site 509170008347 putative homodimer-homodimer interface [polypeptide binding]; other site 509170008348 putative allosteric switch controlling residues; other site 509170008349 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 509170008350 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 509170008351 trmE is a tRNA modification GTPase; Region: trmE; cd04164 509170008352 G1 box; other site 509170008353 GTP/Mg2+ binding site [chemical binding]; other site 509170008354 Switch I region; other site 509170008355 G2 box; other site 509170008356 Switch II region; other site 509170008357 G3 box; other site 509170008358 G4 box; other site 509170008359 G5 box; other site 509170008360 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 509170008361 membrane protein insertase; Provisional; Region: PRK01318 509170008362 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 509170008363 Haemolytic domain; Region: Haemolytic; cl00506 509170008364 Ribonuclease P; Region: Ribonuclease_P; cl00457 509170008365 Ribosomal protein L34; Region: Ribosomal_L34; cl00370