-- dump date 20120504_132856 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443218000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218000003 Magnesium ion binding site [ion binding]; other site 443218000004 LGFP repeat; Region: LGFP; pfam08310 443218000005 LGFP repeat; Region: LGFP; pfam08310 443218000006 LGFP repeat; Region: LGFP; pfam08310 443218000007 Helix-turn-helix domains; Region: HTH; cl00088 443218000008 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443218000009 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218000010 catalytic residues [active] 443218000011 catalytic nucleophile [active] 443218000012 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218000013 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218000014 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218000015 Synaptic Site I dimer interface [polypeptide binding]; other site 443218000016 DNA binding site [nucleotide binding] 443218000017 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218000018 DNA-binding interface [nucleotide binding]; DNA binding site 443218000019 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000021 Family description; Region: UvrD_C_2; cl15862 443218000022 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 443218000023 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218000024 Helix-turn-helix domains; Region: HTH; cl00088 443218000025 Integrase core domain; Region: rve; cl01316 443218000026 Helix-turn-helix domains; Region: HTH; cl00088 443218000027 Cysteine-rich domain; Region: CCG; pfam02754 443218000028 LGFP repeat; Region: LGFP; pfam08310 443218000029 LGFP repeat; Region: LGFP; pfam08310 443218000030 LGFP repeat; Region: LGFP; pfam08310 443218000031 LGFP repeat; Region: LGFP; pfam08310 443218000032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000034 active site 443218000035 phosphorylation site [posttranslational modification] 443218000036 intermolecular recognition site; other site 443218000037 dimerization interface [polypeptide binding]; other site 443218000038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000039 DNA binding residues [nucleotide binding] 443218000040 dimerization interface [polypeptide binding]; other site 443218000041 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 443218000042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218000043 Histidine kinase; Region: HisKA_3; pfam07730 443218000044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218000045 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000046 active site 443218000047 ATP binding site [chemical binding]; other site 443218000048 substrate binding site [chemical binding]; other site 443218000049 activation loop (A-loop); other site 443218000050 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 443218000051 active site 443218000052 zinc binding site [ion binding]; other site 443218000053 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 443218000054 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443218000055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218000056 AAA domain; Region: AAA_31; pfam13614 443218000057 P-loop; other site 443218000058 Magnesium ion binding site [ion binding]; other site 443218000059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000060 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 443218000061 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 443218000062 DNA binding site [nucleotide binding] 443218000063 dimer interface [polypeptide binding]; other site 443218000064 active site 443218000065 Int/Topo IB signature motif; other site 443218000066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000068 AAA domain; Region: AAA_21; pfam13304 443218000069 Walker A/P-loop; other site 443218000070 Walker A/P-loop; other site 443218000071 ATP binding site [chemical binding]; other site 443218000072 ATP binding site [chemical binding]; other site 443218000073 Q-loop/lid; other site 443218000074 ABC transporter signature motif; other site 443218000075 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 443218000076 Walker B; other site 443218000077 D-loop; other site 443218000078 H-loop/switch region; other site 443218000079 RES domain; Region: RES; cl02411 443218000080 RES domain; Region: RES; cl02411 443218000081 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 443218000082 active site 443218000083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218000084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000085 non-specific DNA binding site [nucleotide binding]; other site 443218000086 salt bridge; other site 443218000087 sequence-specific DNA binding site [nucleotide binding]; other site 443218000088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000089 non-specific DNA binding site [nucleotide binding]; other site 443218000090 salt bridge; other site 443218000091 sequence-specific DNA binding site [nucleotide binding]; other site 443218000092 Cutinase; Region: Cutinase; pfam01083 443218000093 AAA-like domain; Region: AAA_10; pfam12846 443218000094 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218000095 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218000096 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218000097 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218000098 catalytic residue [active] 443218000099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000100 Walker A motif; other site 443218000101 ATP binding site [chemical binding]; other site 443218000102 Walker B motif; other site 443218000103 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 443218000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218000105 TrwC relaxase; Region: TrwC; pfam08751 443218000106 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218000107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000108 Family description; Region: UvrD_C_2; cl15862 443218000109 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 443218000110 Protein of unknown function (DUF904); Region: DUF904; cl11531 443218000111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218000112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000113 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218000114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218000116 nucleotide binding region [chemical binding]; other site 443218000117 ATP-binding site [chemical binding]; other site 443218000118 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443218000119 MULE transposase domain; Region: MULE; pfam10551 443218000120 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443218000121 Abortive infection C-terminus; Region: Abi_C; pfam14355 443218000122 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218000123 catalytic nucleophile [active] 443218000124 Predicted helicase [General function prediction only]; Region: COG4889 443218000125 HsdM N-terminal domain; Region: HsdM_N; pfam12161 443218000126 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 443218000127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218000128 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443218000129 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 443218000130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 443218000131 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 443218000132 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 443218000133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000135 Protein of unknown function DUF45; Region: DUF45; cl00636 443218000136 cyclase homology domain; Region: CHD; cd07302 443218000137 nucleotidyl binding site; other site 443218000138 metal binding site [ion binding]; metal-binding site 443218000139 dimer interface [polypeptide binding]; other site 443218000140 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443218000141 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443218000142 putative active site [active] 443218000143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 443218000144 Integrase core domain; Region: rve; cl01316 443218000145 DNA-sulfur modification-associated; Region: DndB; cl14002 443218000146 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443218000147 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218000148 catalytic residues [active] 443218000149 catalytic nucleophile [active] 443218000150 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218000151 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218000152 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218000153 Synaptic Site I dimer interface [polypeptide binding]; other site 443218000154 DNA binding site [nucleotide binding] 443218000155 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218000156 DNA-binding interface [nucleotide binding]; DNA binding site 443218000157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218000158 non-specific DNA binding site [nucleotide binding]; other site 443218000159 salt bridge; other site 443218000160 sequence-specific DNA binding site [nucleotide binding]; other site 443218000161 Domain of unknown function (DUF955); Region: DUF955; cl01076 443218000162 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000163 AAA domain; Region: AAA_21; pfam13304 443218000164 Walker A/P-loop; other site 443218000165 ATP binding site [chemical binding]; other site 443218000166 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 443218000167 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 443218000168 putative active site [active] 443218000169 putative metal-binding site [ion binding]; other site 443218000170 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443218000171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000172 Family description; Region: UvrD_C_2; cl15862 443218000173 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 443218000174 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 443218000175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000176 Walker A motif; other site 443218000177 ATP binding site [chemical binding]; other site 443218000178 Walker B motif; other site 443218000179 arginine finger; other site 443218000180 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443218000181 DnaA box-binding interface [nucleotide binding]; other site 443218000182 DNA polymerase III subunit beta; Validated; Region: PRK07761 443218000183 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443218000184 putative DNA binding surface [nucleotide binding]; other site 443218000185 dimer interface [polypeptide binding]; other site 443218000186 beta-clamp/clamp loader binding surface; other site 443218000187 beta-clamp/translesion DNA polymerase binding surface; other site 443218000188 recombination protein F; Reviewed; Region: recF; PRK00064 443218000189 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 443218000190 Walker A/P-loop; other site 443218000191 ATP binding site [chemical binding]; other site 443218000192 Q-loop/lid; other site 443218000193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000194 ABC transporter signature motif; other site 443218000195 Walker B; other site 443218000196 D-loop; other site 443218000197 H-loop/switch region; other site 443218000198 Protein of unknown function (DUF721); Region: DUF721; cl02324 443218000199 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443218000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218000201 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443218000202 anchoring element; other site 443218000203 dimer interface [polypeptide binding]; other site 443218000204 ATP binding site [chemical binding]; other site 443218000205 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443218000206 active site 443218000207 putative metal-binding site [ion binding]; other site 443218000208 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443218000209 DNA gyrase subunit A; Validated; Region: PRK05560 443218000210 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 443218000211 CAP-like domain; other site 443218000212 active site 443218000213 primary dimer interface [polypeptide binding]; other site 443218000214 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000215 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000218 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000219 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443218000220 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443218000221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218000222 putative substrate translocation pore; other site 443218000223 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 443218000224 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218000225 NAD(P) binding site [chemical binding]; other site 443218000226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218000227 active site 443218000228 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 443218000229 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218000230 ATP binding site [chemical binding]; other site 443218000231 Mg++ binding site [ion binding]; other site 443218000232 motif III; other site 443218000233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218000234 nucleotide binding region [chemical binding]; other site 443218000235 ATP-binding site [chemical binding]; other site 443218000236 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218000237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218000238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000239 Helix-turn-helix domains; Region: HTH; cl00088 443218000240 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218000241 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218000242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218000243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218000244 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218000245 hydrophobic ligand binding site; other site 443218000246 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 443218000247 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 443218000248 active site 443218000249 Rhomboid family; Region: Rhomboid; cl11446 443218000250 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 443218000251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 443218000252 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218000253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443218000254 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443218000255 glutamine binding [chemical binding]; other site 443218000256 catalytic triad [active] 443218000257 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218000259 active site 443218000260 ATP binding site [chemical binding]; other site 443218000261 substrate binding site [chemical binding]; other site 443218000262 activation loop (A-loop); other site 443218000263 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000264 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000265 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000267 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218000269 active site 443218000270 ATP binding site [chemical binding]; other site 443218000271 substrate binding site [chemical binding]; other site 443218000272 activation loop (A-loop); other site 443218000273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218000274 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443218000275 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443218000276 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 443218000277 active site 443218000278 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218000279 phosphopeptide binding site; other site 443218000280 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443218000281 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218000282 phosphopeptide binding site; other site 443218000283 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443218000284 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443218000285 active site 443218000286 dimer interface [polypeptide binding]; other site 443218000287 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443218000288 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218000289 active site 443218000290 FMN binding site [chemical binding]; other site 443218000291 substrate binding site [chemical binding]; other site 443218000292 3Fe-4S cluster binding site [ion binding]; other site 443218000293 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443218000294 domain interface; other site 443218000295 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443218000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000297 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 443218000298 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 443218000299 putative active site [active] 443218000300 putative substrate binding site [chemical binding]; other site 443218000301 putative FMN binding site [chemical binding]; other site 443218000302 putative catalytic residues [active] 443218000303 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218000304 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000305 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 443218000306 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 443218000307 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218000308 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218000309 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218000310 NAD(P) binding site [chemical binding]; other site 443218000311 catalytic residues [active] 443218000312 CsbD-like; Region: CsbD; cl15799 443218000313 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218000314 hydrophobic ligand binding site; other site 443218000315 Copper resistance protein D; Region: CopD; cl00563 443218000316 Bacterial Ig-like domain; Region: Big_5; cl01012 443218000317 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443218000318 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 443218000319 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 443218000320 Dehydratase family; Region: ILVD_EDD; cl00340 443218000321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000322 NAD(P) binding site [chemical binding]; other site 443218000323 active site 443218000324 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 443218000325 MgtE intracellular N domain; Region: MgtE_N; cl15244 443218000326 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443218000327 Divalent cation transporter; Region: MgtE; cl00786 443218000328 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443218000329 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443218000330 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443218000331 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 443218000332 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218000333 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218000334 Walker A/P-loop; other site 443218000335 ATP binding site [chemical binding]; other site 443218000336 Q-loop/lid; other site 443218000337 ABC transporter signature motif; other site 443218000338 Walker B; other site 443218000339 D-loop; other site 443218000340 H-loop/switch region; other site 443218000341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218000342 Histidine kinase; Region: HisKA_3; pfam07730 443218000343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000345 active site 443218000346 phosphorylation site [posttranslational modification] 443218000347 intermolecular recognition site; other site 443218000348 dimerization interface [polypeptide binding]; other site 443218000349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000350 DNA binding residues [nucleotide binding] 443218000351 dimerization interface [polypeptide binding]; other site 443218000352 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 443218000353 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218000354 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218000355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218000357 Walker A/P-loop; other site 443218000358 ATP binding site [chemical binding]; other site 443218000359 Q-loop/lid; other site 443218000360 ABC transporter signature motif; other site 443218000361 Walker B; other site 443218000362 D-loop; other site 443218000363 H-loop/switch region; other site 443218000364 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 443218000365 oligomer interface [polypeptide binding]; other site 443218000366 tandem repeat interface [polypeptide binding]; other site 443218000367 active site residues [active] 443218000368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218000369 active site residue [active] 443218000370 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 443218000371 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218000372 active site 443218000373 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 443218000374 Ferritin-like domain; Region: Ferritin; pfam00210 443218000375 ferroxidase diiron center [ion binding]; other site 443218000376 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 443218000377 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 443218000378 dimerization interface [polypeptide binding]; other site 443218000379 substrate binding pocket [chemical binding]; other site 443218000380 CAAX protease self-immunity; Region: Abi; cl00558 443218000381 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 443218000382 prephenate dehydratase; Provisional; Region: PRK11898 443218000383 Prephenate dehydratase; Region: PDT; pfam00800 443218000384 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443218000385 putative L-Phe binding site [chemical binding]; other site 443218000386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218000387 catalytic core [active] 443218000388 EspG family; Region: ESX-1_EspG; pfam14011 443218000389 PPE family; Region: PPE; pfam00823 443218000390 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 443218000391 Septum formation; Region: Septum_form; pfam13845 443218000392 Septum formation; Region: Septum_form; pfam13845 443218000393 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 443218000394 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 443218000395 seryl-tRNA synthetase; Provisional; Region: PRK05431 443218000396 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443218000397 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 443218000398 dimer interface [polypeptide binding]; other site 443218000399 active site 443218000400 motif 1; other site 443218000401 motif 2; other site 443218000402 motif 3; other site 443218000403 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218000404 CoenzymeA binding site [chemical binding]; other site 443218000405 subunit interaction site [polypeptide binding]; other site 443218000406 PHB binding site; other site 443218000407 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218000408 putative acyl-acceptor binding pocket; other site 443218000409 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218000410 putative acyl-acceptor binding pocket; other site 443218000411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218000412 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443218000413 active site 443218000414 motif I; other site 443218000415 motif II; other site 443218000416 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218000417 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443218000418 amidase catalytic site [active] 443218000419 Zn binding residues [ion binding]; other site 443218000420 substrate binding site [chemical binding]; other site 443218000421 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000422 LGFP repeat; Region: LGFP; pfam08310 443218000423 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443218000424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000425 UDP-galactopyranose mutase; Region: GLF; pfam03275 443218000426 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218000427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218000428 active site 443218000429 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443218000430 active site 443218000431 UbiA prenyltransferase family; Region: UbiA; cl00337 443218000432 Predicted esterase [General function prediction only]; Region: COG0627 443218000433 Predicted esterase [General function prediction only]; Region: COG0627 443218000434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218000435 LGFP repeat; Region: LGFP; pfam08310 443218000436 LGFP repeat; Region: LGFP; pfam08310 443218000437 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 443218000438 LGFP repeat; Region: LGFP; pfam08310 443218000439 Cutinase; Region: Cutinase; pfam01083 443218000440 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 443218000441 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000443 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218000444 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 443218000445 active site 443218000446 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218000447 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000448 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443218000449 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218000450 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218000451 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218000452 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443218000453 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 443218000454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 443218000455 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218000456 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218000457 iron-sulfur cluster [ion binding]; other site 443218000458 [2Fe-2S] cluster binding site [ion binding]; other site 443218000459 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 443218000460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218000461 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 443218000462 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218000463 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218000464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000465 NAD(P) binding site [chemical binding]; other site 443218000466 active site 443218000467 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218000468 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000469 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 443218000470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000471 Helix-turn-helix domains; Region: HTH; cl00088 443218000472 WHG domain; Region: WHG; pfam13305 443218000473 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 443218000474 putative hydrophobic ligand binding site [chemical binding]; other site 443218000475 GtrA-like protein; Region: GtrA; cl00971 443218000476 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 443218000477 Cupin domain; Region: Cupin_2; cl09118 443218000478 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443218000479 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443218000480 substrate binding site; other site 443218000481 tetramer interface; other site 443218000482 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218000483 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218000484 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 443218000485 Histidine kinase; Region: HisKA_3; pfam07730 443218000486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218000487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218000489 active site 443218000490 phosphorylation site [posttranslational modification] 443218000491 intermolecular recognition site; other site 443218000492 dimerization interface [polypeptide binding]; other site 443218000493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218000494 DNA binding residues [nucleotide binding] 443218000495 dimerization interface [polypeptide binding]; other site 443218000496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218000497 ABC-ATPase subunit interface; other site 443218000498 dimer interface [polypeptide binding]; other site 443218000499 putative PBP binding regions; other site 443218000500 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218000501 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218000502 Walker A/P-loop; other site 443218000503 ATP binding site [chemical binding]; other site 443218000504 Q-loop/lid; other site 443218000505 ABC transporter signature motif; other site 443218000506 Walker B; other site 443218000507 D-loop; other site 443218000508 H-loop/switch region; other site 443218000509 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218000510 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218000511 intersubunit interface [polypeptide binding]; other site 443218000512 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443218000513 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443218000514 NAD binding site [chemical binding]; other site 443218000515 substrate binding site [chemical binding]; other site 443218000516 homodimer interface [polypeptide binding]; other site 443218000517 active site 443218000518 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 443218000519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000520 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 443218000521 catalytic triad [active] 443218000522 conserved cis-peptide bond; other site 443218000523 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 443218000524 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000525 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000528 NAD(P) binding site [chemical binding]; other site 443218000529 active site 443218000530 isochorismate synthase DhbC; Validated; Region: PRK06923 443218000531 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218000532 peptide synthase; Provisional; Region: PRK12467 443218000533 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000534 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000535 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000536 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218000537 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000538 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000539 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218000540 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218000541 intersubunit interface [polypeptide binding]; other site 443218000542 peptide synthase; Provisional; Region: PRK12316 443218000543 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000544 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000545 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218000546 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000547 enterobactin exporter EntS; Provisional; Region: PRK10489 443218000548 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218000549 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218000550 FAD binding pocket [chemical binding]; other site 443218000551 FAD binding motif [chemical binding]; other site 443218000552 phosphate binding motif [ion binding]; other site 443218000553 NAD binding pocket [chemical binding]; other site 443218000554 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 443218000555 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 443218000556 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218000557 metal ion-dependent adhesion site (MIDAS); other site 443218000558 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 443218000559 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218000560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218000561 active site 443218000562 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443218000563 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 443218000564 Walker A/P-loop; other site 443218000565 ATP binding site [chemical binding]; other site 443218000566 Q-loop/lid; other site 443218000567 ABC transporter signature motif; other site 443218000568 Walker B; other site 443218000569 D-loop; other site 443218000570 H-loop/switch region; other site 443218000571 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218000572 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 443218000573 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443218000574 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443218000575 NAD(P) binding site [chemical binding]; other site 443218000576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218000577 Helix-turn-helix domains; Region: HTH; cl00088 443218000578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000579 classical (c) SDRs; Region: SDR_c; cd05233 443218000580 NAD(P) binding site [chemical binding]; other site 443218000581 active site 443218000582 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218000583 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218000584 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443218000585 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218000586 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218000587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000588 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218000589 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 443218000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000591 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 443218000592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000595 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000596 NAD(P) binding site [chemical binding]; other site 443218000597 active site 443218000598 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218000599 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218000600 classical (c) SDRs; Region: SDR_c; cd05233 443218000601 NAD(P) binding site [chemical binding]; other site 443218000602 active site 443218000603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218000604 Helix-turn-helix domains; Region: HTH; cl00088 443218000605 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443218000606 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 443218000607 putative active site [active] 443218000608 Fe(II) binding site [ion binding]; other site 443218000609 putative dimer interface [polypeptide binding]; other site 443218000610 putative tetramer interface [polypeptide binding]; other site 443218000611 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218000612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218000613 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218000614 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218000615 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443218000616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000617 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443218000618 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443218000619 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443218000620 active site 443218000621 catalytic residues [active] 443218000622 metal binding site [ion binding]; metal-binding site 443218000623 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443218000624 putative succinate dehydrogenase; Reviewed; Region: PRK12842 443218000625 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218000626 hydrophobic ligand binding site; other site 443218000627 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 443218000628 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218000629 active site 443218000630 metal binding site [ion binding]; metal-binding site 443218000631 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 443218000632 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 443218000633 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218000634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218000635 homodimer interface [polypeptide binding]; other site 443218000636 catalytic residue [active] 443218000637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218000638 haloalkane dehalogenase; Provisional; Region: PRK03204 443218000639 Helix-turn-helix domains; Region: HTH; cl00088 443218000640 SCP-2 sterol transfer family; Region: SCP2; cl01225 443218000641 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 443218000642 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443218000643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218000644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218000645 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218000646 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443218000647 catalytic triad [active] 443218000648 Thioesterase domain; Region: Thioesterase; pfam00975 443218000649 Protein of unknown function (DUF421); Region: DUF421; cl00990 443218000650 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 443218000651 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 443218000652 Amidase; Region: Amidase; cl11426 443218000653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000654 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 443218000655 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443218000656 dimer interface [polypeptide binding]; other site 443218000657 catalytic motif [active] 443218000658 Protein of unknown function DUF262; Region: DUF262; cl14890 443218000659 Excalibur calcium-binding domain; Region: Excalibur; cl05460 443218000660 Inner membrane protein CreD; Region: CreD; cl01844 443218000661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218000662 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 443218000663 putative deacylase active site [active] 443218000664 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218000665 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443218000666 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 443218000667 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 443218000668 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 443218000669 RDD family; Region: RDD; cl00746 443218000670 Bacitracin resistance protein BacA; Region: BacA; cl00858 443218000671 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 443218000672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218000673 active site 443218000674 HIGH motif; other site 443218000675 nucleotide binding site [chemical binding]; other site 443218000676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218000677 active site 443218000678 KMSKS motif; other site 443218000679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218000680 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 443218000681 Membrane transport protein; Region: Mem_trans; cl09117 443218000682 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 443218000683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218000684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218000685 homodimer interface [polypeptide binding]; other site 443218000686 catalytic residue [active] 443218000687 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443218000688 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218000689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218000690 S-adenosylmethionine binding site [chemical binding]; other site 443218000691 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 443218000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000693 Walker A motif; other site 443218000694 ATP binding site [chemical binding]; other site 443218000695 Walker B motif; other site 443218000696 arginine finger; other site 443218000697 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443218000698 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 443218000699 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443218000700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218000701 S-adenosylmethionine binding site [chemical binding]; other site 443218000702 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218000703 FAD binding domain; Region: FAD_binding_4; pfam01565 443218000704 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218000705 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 443218000706 recombination protein RecR; Reviewed; Region: recR; PRK00076 443218000707 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218000708 RecR protein; Region: RecR; pfam02132 443218000709 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443218000710 putative active site [active] 443218000711 putative metal-binding site [ion binding]; other site 443218000712 tetramer interface [polypeptide binding]; other site 443218000713 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443218000714 catalytic triad [active] 443218000715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218000716 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443218000717 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 443218000718 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 443218000719 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 443218000720 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218000721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218000722 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 443218000723 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 443218000724 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218000725 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218000726 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218000727 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218000728 2-isopropylmalate synthase; Validated; Region: PRK03739 443218000729 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443218000730 active site 443218000731 catalytic residues [active] 443218000732 metal binding site [ion binding]; metal-binding site 443218000733 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 443218000734 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443218000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000736 aspartate kinase; Reviewed; Region: PRK06635 443218000737 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443218000738 putative nucleotide binding site [chemical binding]; other site 443218000739 putative catalytic residues [active] 443218000740 putative Mg ion binding site [ion binding]; other site 443218000741 putative aspartate binding site [chemical binding]; other site 443218000742 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443218000743 putative allosteric regulatory site; other site 443218000744 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443218000745 putative allosteric regulatory residue; other site 443218000746 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443218000747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000748 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 443218000749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443218000750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218000751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218000752 Helix-turn-helix domains; Region: HTH; cl00088 443218000753 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218000754 active site 443218000755 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218000756 active site 443218000757 short chain dehydrogenase; Provisional; Region: PRK07825 443218000758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000759 NAD(P) binding site [chemical binding]; other site 443218000760 active site 443218000761 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218000762 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218000763 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218000764 metal binding site 2 [ion binding]; metal-binding site 443218000765 putative DNA binding helix; other site 443218000766 metal binding site 1 [ion binding]; metal-binding site 443218000767 dimer interface [polypeptide binding]; other site 443218000768 structural Zn2+ binding site [ion binding]; other site 443218000769 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 443218000770 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 443218000771 tetramer interface [polypeptide binding]; other site 443218000772 heme binding pocket [chemical binding]; other site 443218000773 NADPH binding site [chemical binding]; other site 443218000774 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 443218000775 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 443218000776 dimerization interface [polypeptide binding]; other site 443218000777 DPS ferroxidase diiron center [ion binding]; other site 443218000778 ion pore; other site 443218000779 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443218000780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000781 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 443218000782 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 443218000783 Cation transport protein; Region: TrkH; cl10514 443218000784 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443218000785 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443218000786 putative active site [active] 443218000787 putative metal binding site [ion binding]; other site 443218000788 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443218000789 Transglycosylase; Region: Transgly; cl07896 443218000790 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218000791 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218000792 Transcription factor WhiB; Region: Whib; pfam02467 443218000793 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218000794 DTAP/Switch II; other site 443218000795 Switch I; other site 443218000796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000797 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218000798 DTAP/Switch II; other site 443218000799 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443218000800 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443218000801 homotrimer interaction site [polypeptide binding]; other site 443218000802 putative active site [active] 443218000803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218000804 catalytic core [active] 443218000805 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 443218000806 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443218000807 putative active site [active] 443218000808 putative substrate binding site [chemical binding]; other site 443218000809 ATP binding site [chemical binding]; other site 443218000810 short chain dehydrogenase; Provisional; Region: PRK08251 443218000811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000812 NAD(P) binding site [chemical binding]; other site 443218000813 active site 443218000814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218000815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218000816 active site 443218000817 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218000821 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 443218000822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 443218000823 ligand binding site [chemical binding]; other site 443218000824 flexible hinge region; other site 443218000825 Helix-turn-helix domains; Region: HTH; cl00088 443218000826 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 443218000827 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218000828 minor groove reading motif; other site 443218000829 helix-hairpin-helix signature motif; other site 443218000830 substrate binding pocket [chemical binding]; other site 443218000831 active site 443218000832 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 443218000833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443218000834 catalytic residues [active] 443218000835 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443218000836 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443218000837 putative active site [active] 443218000838 putative CoA binding site [chemical binding]; other site 443218000839 nudix motif; other site 443218000840 metal binding site [ion binding]; metal-binding site 443218000841 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218000842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218000843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218000844 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 443218000845 Helix-turn-helix domains; Region: HTH; cl00088 443218000846 acetyl-CoA synthetase; Provisional; Region: PRK00174 443218000847 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 443218000848 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218000850 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218000851 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218000852 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 443218000853 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 443218000854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000855 Walker A motif; other site 443218000856 ATP binding site [chemical binding]; other site 443218000857 Walker B motif; other site 443218000858 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 443218000859 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 443218000860 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 443218000861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218000862 ATP binding site [chemical binding]; other site 443218000863 putative Mg++ binding site [ion binding]; other site 443218000864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218000865 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 443218000866 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218000867 active site 443218000868 catalytic triad [active] 443218000869 oxyanion hole [active] 443218000870 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 443218000871 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443218000872 active site 443218000873 interdomain interaction site; other site 443218000874 putative metal-binding site [ion binding]; other site 443218000875 nucleotide binding site [chemical binding]; other site 443218000876 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 443218000877 domain I; other site 443218000878 phosphate binding site [ion binding]; other site 443218000879 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443218000880 domain II; other site 443218000881 domain III; other site 443218000882 nucleotide binding site [chemical binding]; other site 443218000883 DNA binding groove [nucleotide binding] 443218000884 catalytic site [active] 443218000885 domain IV; other site 443218000886 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000887 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000888 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443218000889 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218000890 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218000891 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 443218000892 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218000893 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 443218000894 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 443218000895 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 443218000896 active site 443218000897 P-loop; other site 443218000898 phosphorylation site [posttranslational modification] 443218000899 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 443218000900 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443218000901 active site 443218000902 phosphorylation site [posttranslational modification] 443218000903 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443218000904 putative substrate binding site [chemical binding]; other site 443218000905 putative ATP binding site [chemical binding]; other site 443218000906 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443218000907 Helix-turn-helix domains; Region: HTH; cl00088 443218000908 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218000909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218000910 dimerization interface [polypeptide binding]; other site 443218000911 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218000912 cyclase homology domain; Region: CHD; cd07302 443218000913 nucleotidyl binding site; other site 443218000914 metal binding site [ion binding]; metal-binding site 443218000915 dimer interface [polypeptide binding]; other site 443218000916 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443218000917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000918 Walker A motif; other site 443218000919 ATP binding site [chemical binding]; other site 443218000920 Walker B motif; other site 443218000921 arginine finger; other site 443218000922 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 443218000923 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 443218000924 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 443218000925 heme binding site [chemical binding]; other site 443218000926 ferroxidase pore; other site 443218000927 ferroxidase diiron center [ion binding]; other site 443218000928 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 443218000929 Helix-turn-helix domains; Region: HTH; cl00088 443218000930 FCD domain; Region: FCD; cl11656 443218000931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218000932 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 443218000933 Zn binding site [ion binding]; other site 443218000934 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 443218000935 AMP-binding enzyme; Region: AMP-binding; cl15778 443218000936 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218000937 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 443218000938 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218000939 putative trimer interface [polypeptide binding]; other site 443218000940 putative CoA binding site [chemical binding]; other site 443218000941 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218000942 putative trimer interface [polypeptide binding]; other site 443218000943 putative CoA binding site [chemical binding]; other site 443218000944 Helix-turn-helix domains; Region: HTH; cl00088 443218000945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218000946 Helix-turn-helix domains; Region: HTH; cl00088 443218000947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218000948 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218000949 substrate binding pocket [chemical binding]; other site 443218000950 membrane-bound complex binding site; other site 443218000951 hinge residues; other site 443218000952 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443218000953 dimer interface [polypeptide binding]; other site 443218000954 substrate binding site [chemical binding]; other site 443218000955 metal binding sites [ion binding]; metal-binding site 443218000956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218000957 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 443218000958 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443218000959 Ligand Binding Site [chemical binding]; other site 443218000960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218000961 active site 443218000962 FtsH Extracellular; Region: FtsH_ext; pfam06480 443218000963 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443218000964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218000965 Walker A motif; other site 443218000966 ATP binding site [chemical binding]; other site 443218000967 Walker B motif; other site 443218000968 arginine finger; other site 443218000969 Peptidase family M41; Region: Peptidase_M41; pfam01434 443218000970 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 443218000971 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 443218000972 homodecamer interface [polypeptide binding]; other site 443218000973 GTP cyclohydrolase I; Provisional; Region: PLN03044 443218000974 active site 443218000975 putative catalytic site residues [active] 443218000976 zinc binding site [ion binding]; other site 443218000977 GTP-CH-I/GFRP interaction surface; other site 443218000978 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218000979 dihydropteroate synthase; Region: DHPS; TIGR01496 443218000980 substrate binding pocket [chemical binding]; other site 443218000981 dimer interface [polypeptide binding]; other site 443218000982 inhibitor binding site; inhibition site 443218000983 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 443218000984 active site 443218000985 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443218000986 catalytic center binding site [active] 443218000987 ATP binding site [chemical binding]; other site 443218000988 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443218000989 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218000990 Uncharacterized conserved protein [Function unknown]; Region: COG5495 443218000991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218000992 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443218000993 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443218000994 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443218000995 active site 443218000996 ATP-binding site [chemical binding]; other site 443218000997 pantoate-binding site; other site 443218000998 HXXH motif; other site 443218000999 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443218001000 tetramerization interface [polypeptide binding]; other site 443218001001 active site 443218001002 Type III pantothenate kinase; Region: Pan_kinase; cl09130 443218001003 Cysteine dioxygenase type I; Region: CDO_I; cl15835 443218001004 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218001005 active site residue [active] 443218001006 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218001007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218001008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218001009 DNA binding residues [nucleotide binding] 443218001010 Asp23 family; Region: Asp23; cl00574 443218001011 Asp23 family; Region: Asp23; cl00574 443218001012 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443218001013 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443218001014 dimer interface [polypeptide binding]; other site 443218001015 putative anticodon binding site; other site 443218001016 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 443218001017 motif 1; other site 443218001018 dimer interface [polypeptide binding]; other site 443218001019 active site 443218001020 motif 2; other site 443218001021 motif 3; other site 443218001022 Lsr2; Region: Lsr2; pfam11774 443218001023 Clp protease ATP binding subunit; Region: clpC; CHL00095 443218001024 Clp amino terminal domain; Region: Clp_N; pfam02861 443218001025 Clp amino terminal domain; Region: Clp_N; pfam02861 443218001026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001027 Walker A motif; other site 443218001028 ATP binding site [chemical binding]; other site 443218001029 Walker B motif; other site 443218001030 arginine finger; other site 443218001031 UvrB/uvrC motif; Region: UVR; pfam02151 443218001032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001033 Walker A motif; other site 443218001034 ATP binding site [chemical binding]; other site 443218001035 Walker B motif; other site 443218001036 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 443218001037 OsmC-like protein; Region: OsmC; cl00767 443218001038 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 443218001039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218001040 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 443218001041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001042 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218001043 endonuclease III; Region: ENDO3c; smart00478 443218001044 minor groove reading motif; other site 443218001045 helix-hairpin-helix signature motif; other site 443218001046 substrate binding pocket [chemical binding]; other site 443218001047 active site 443218001048 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443218001049 active site clefts [active] 443218001050 zinc binding site [ion binding]; other site 443218001051 dimer interface [polypeptide binding]; other site 443218001052 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218001053 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 443218001054 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 443218001055 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 443218001056 DNA repair protein RadA; Provisional; Region: PRK11823 443218001057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218001058 Walker A motif; other site 443218001059 ATP binding site [chemical binding]; other site 443218001060 Walker B motif; other site 443218001061 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 443218001062 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 443218001063 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443218001064 CDP-binding sites; other site 443218001065 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443218001066 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218001067 active site 443218001068 HIGH motif; other site 443218001069 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218001070 KMSKS motif; other site 443218001071 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443218001072 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218001073 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 443218001074 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 443218001075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001076 active site 443218001077 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443218001078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218001079 inhibitor-cofactor binding pocket; inhibition site 443218001080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218001081 catalytic residue [active] 443218001082 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443218001083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001084 catalytic core [active] 443218001085 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443218001086 catalytic residues [active] 443218001087 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443218001088 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443218001089 ResB-like family; Region: ResB; pfam05140 443218001090 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 443218001091 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443218001092 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218001093 P-loop; other site 443218001094 Magnesium ion binding site [ion binding]; other site 443218001095 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 443218001096 DNA binding residues [nucleotide binding] 443218001097 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443218001098 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443218001099 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443218001100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218001101 catalytic residue [active] 443218001102 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 443218001103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218001104 Walker A/P-loop; other site 443218001105 ATP binding site [chemical binding]; other site 443218001106 Q-loop/lid; other site 443218001107 ABC transporter signature motif; other site 443218001108 Walker B; other site 443218001109 D-loop; other site 443218001110 H-loop/switch region; other site 443218001111 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443218001112 FtsX-like permease family; Region: FtsX; cl15850 443218001113 Membrane protein of unknown function; Region: DUF360; cl00850 443218001114 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218001115 Helix-turn-helix domains; Region: HTH; cl00088 443218001116 Integrase core domain; Region: rve; cl01316 443218001117 UbiA prenyltransferase family; Region: UbiA; cl00337 443218001118 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 443218001119 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218001121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218001122 active site 443218001123 metal binding site [ion binding]; metal-binding site 443218001124 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443218001125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001126 substrate binding site [chemical binding]; other site 443218001127 oxyanion hole (OAH) forming residues; other site 443218001128 trimer interface [polypeptide binding]; other site 443218001129 Ferredoxin [Energy production and conversion]; Region: COG1146 443218001130 4Fe-4S binding domain; Region: Fer4; cl02805 443218001131 ferredoxin-NADP+ reductase; Region: PLN02852 443218001132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001133 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443218001134 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443218001135 active site 443218001136 Flavin Reductases; Region: FlaRed; cl00801 443218001137 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443218001138 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443218001139 dimer interface [polypeptide binding]; other site 443218001140 tetramer interface [polypeptide binding]; other site 443218001141 PYR/PP interface [polypeptide binding]; other site 443218001142 TPP binding site [chemical binding]; other site 443218001143 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443218001144 TPP-binding site; other site 443218001145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218001146 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443218001147 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443218001148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218001149 S-adenosylmethionine binding site [chemical binding]; other site 443218001150 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218001151 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218001152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001153 Helix-turn-helix domains; Region: HTH; cl00088 443218001154 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443218001155 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443218001156 substrate binding pocket [chemical binding]; other site 443218001157 chain length determination region; other site 443218001158 substrate-Mg2+ binding site; other site 443218001159 catalytic residues [active] 443218001160 aspartate-rich region 1; other site 443218001161 active site lid residues [active] 443218001162 aspartate-rich region 2; other site 443218001163 Peptidase family M48; Region: Peptidase_M48; cl12018 443218001164 Protein of unknown function (DUF520); Region: DUF520; cl00723 443218001165 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218001166 active site 443218001167 catalytic site [active] 443218001168 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218001169 active site 2 [active] 443218001170 active site 1 [active] 443218001171 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443218001172 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 443218001173 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 443218001174 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443218001175 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443218001176 putative homodimer interface [polypeptide binding]; other site 443218001177 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443218001178 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443218001179 23S rRNA interface [nucleotide binding]; other site 443218001180 L7/L12 interface [polypeptide binding]; other site 443218001181 putative thiostrepton binding site; other site 443218001182 L25 interface [polypeptide binding]; other site 443218001183 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443218001184 mRNA/rRNA interface [nucleotide binding]; other site 443218001185 Integrase core domain; Region: rve; cl01316 443218001186 Integrase core domain; Region: rve_3; cl15866 443218001187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001188 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001189 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443218001190 23S rRNA interface [nucleotide binding]; other site 443218001191 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443218001192 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443218001193 core dimer interface [polypeptide binding]; other site 443218001194 peripheral dimer interface [polypeptide binding]; other site 443218001195 L10 interface [polypeptide binding]; other site 443218001196 L11 interface [polypeptide binding]; other site 443218001197 putative EF-Tu interaction site [polypeptide binding]; other site 443218001198 putative EF-G interaction site [polypeptide binding]; other site 443218001199 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218001200 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 443218001201 Walker A/P-loop; other site 443218001202 ATP binding site [chemical binding]; other site 443218001203 Q-loop/lid; other site 443218001204 ABC transporter signature motif; other site 443218001205 Walker B; other site 443218001206 D-loop; other site 443218001207 H-loop/switch region; other site 443218001208 Permease; Region: Permease; cl00510 443218001209 Permease; Region: Permease; cl00510 443218001210 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218001211 mce related protein; Region: MCE; pfam02470 443218001212 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001213 mce related protein; Region: MCE; pfam02470 443218001214 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001215 mce related protein; Region: MCE; pfam02470 443218001216 mce related protein; Region: MCE; pfam02470 443218001217 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001218 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001219 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001220 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218001221 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 443218001222 Walker A/P-loop; other site 443218001223 ATP binding site [chemical binding]; other site 443218001224 Q-loop/lid; other site 443218001225 ABC transporter signature motif; other site 443218001226 Walker B; other site 443218001227 D-loop; other site 443218001228 H-loop/switch region; other site 443218001229 Permease; Region: Permease; cl00510 443218001230 Permease; Region: Permease; cl00510 443218001231 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001232 mce related protein; Region: MCE; pfam02470 443218001233 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001234 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001235 mce related protein; Region: MCE; pfam02470 443218001236 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001237 mce related protein; Region: MCE; pfam02470 443218001238 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218001239 mce related protein; Region: MCE; pfam02470 443218001240 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001241 mce related protein; Region: MCE; pfam02470 443218001242 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001243 mce related protein; Region: MCE; pfam02470 443218001244 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218001245 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 443218001246 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443218001247 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443218001248 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443218001249 RPB10 interaction site [polypeptide binding]; other site 443218001250 RPB1 interaction site [polypeptide binding]; other site 443218001251 RPB11 interaction site [polypeptide binding]; other site 443218001252 RPB3 interaction site [polypeptide binding]; other site 443218001253 RPB12 interaction site [polypeptide binding]; other site 443218001254 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443218001255 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 443218001256 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443218001257 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 443218001258 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443218001259 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 443218001260 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443218001261 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443218001262 G-loop; other site 443218001263 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443218001264 DNA binding site [nucleotide binding] 443218001265 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443218001266 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 443218001267 putative active site [active] 443218001268 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 443218001269 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218001270 active site 443218001271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218001272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001273 catalytic core [active] 443218001274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001276 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218001277 hydrophobic ligand binding site; other site 443218001278 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 443218001279 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218001280 active site 443218001281 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218001282 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001283 substrate binding site [chemical binding]; other site 443218001284 oxyanion hole (OAH) forming residues; other site 443218001285 trimer interface [polypeptide binding]; other site 443218001286 TIGR03084 family protein; Region: TIGR03084 443218001287 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218001288 Wyosine base formation; Region: Wyosine_form; pfam08608 443218001289 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 443218001290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218001291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001292 active site 443218001293 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 443218001294 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218001295 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218001296 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218001297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218001298 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218001299 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218001300 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218001301 carboxyltransferase (CT) interaction site; other site 443218001302 biotinylation site [posttranslational modification]; other site 443218001303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218001304 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218001305 active site 443218001306 enoyl-CoA hydratase; Provisional; Region: PRK07827 443218001307 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218001308 substrate binding site [chemical binding]; other site 443218001309 oxyanion hole (OAH) forming residues; other site 443218001310 trimer interface [polypeptide binding]; other site 443218001311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001312 Helix-turn-helix domains; Region: HTH; cl00088 443218001313 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218001314 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218001315 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443218001316 S17 interaction site [polypeptide binding]; other site 443218001317 S8 interaction site; other site 443218001318 16S rRNA interaction site [nucleotide binding]; other site 443218001319 streptomycin interaction site [chemical binding]; other site 443218001320 23S rRNA interaction site [nucleotide binding]; other site 443218001321 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443218001322 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 443218001323 elongation factor G; Reviewed; Region: PRK00007 443218001324 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443218001325 G1 box; other site 443218001326 putative GEF interaction site [polypeptide binding]; other site 443218001327 GTP/Mg2+ binding site [chemical binding]; other site 443218001328 Switch I region; other site 443218001329 G2 box; other site 443218001330 G3 box; other site 443218001331 Switch II region; other site 443218001332 G4 box; other site 443218001333 G5 box; other site 443218001334 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443218001335 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443218001336 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443218001337 elongation factor Tu; Reviewed; Region: PRK00049 443218001338 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443218001339 G1 box; other site 443218001340 GEF interaction site [polypeptide binding]; other site 443218001341 GTP/Mg2+ binding site [chemical binding]; other site 443218001342 Switch I region; other site 443218001343 G2 box; other site 443218001344 G3 box; other site 443218001345 Switch II region; other site 443218001346 G4 box; other site 443218001347 G5 box; other site 443218001348 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443218001349 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443218001350 Antibiotic Binding Site [chemical binding]; other site 443218001351 peptide synthase; Provisional; Region: PRK12316 443218001352 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001353 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001354 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218001355 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001356 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001357 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001358 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 443218001359 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001360 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001361 peptide synthase; Provisional; Region: PRK12467 443218001362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001363 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001364 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001365 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001366 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001367 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001368 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001369 peptide synthase; Provisional; Region: PRK12316 443218001370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001371 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001372 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443218001373 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001374 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001375 peptide synthase; Provisional; Region: PRK12467 443218001376 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001377 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001378 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001379 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001380 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001381 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001382 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001383 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218001384 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001385 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001386 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218001387 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218001388 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218001390 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001391 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001392 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218001393 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218001394 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218001395 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218001396 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218001397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218001398 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218001399 Walker A/P-loop; other site 443218001400 ATP binding site [chemical binding]; other site 443218001401 Q-loop/lid; other site 443218001402 ABC transporter signature motif; other site 443218001403 Walker B; other site 443218001404 D-loop; other site 443218001405 H-loop/switch region; other site 443218001406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001409 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218001410 CoenzymeA binding site [chemical binding]; other site 443218001411 subunit interaction site [polypeptide binding]; other site 443218001412 PHB binding site; other site 443218001413 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 443218001414 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 443218001415 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 443218001416 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 443218001417 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443218001418 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443218001419 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443218001420 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 443218001421 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443218001422 putative translocon binding site; other site 443218001423 protein-rRNA interface [nucleotide binding]; other site 443218001424 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443218001425 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443218001426 G-X-X-G motif; other site 443218001427 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443218001428 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443218001429 23S rRNA interface [nucleotide binding]; other site 443218001430 5S rRNA interface [nucleotide binding]; other site 443218001431 putative antibiotic binding site [chemical binding]; other site 443218001432 L25 interface [polypeptide binding]; other site 443218001433 L27 interface [polypeptide binding]; other site 443218001434 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443218001435 23S rRNA interface [nucleotide binding]; other site 443218001436 putative translocon interaction site; other site 443218001437 signal recognition particle (SRP54) interaction site; other site 443218001438 L23 interface [polypeptide binding]; other site 443218001439 trigger factor interaction site; other site 443218001440 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 443218001441 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 443218001442 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443218001443 KOW motif; Region: KOW; cl00354 443218001444 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443218001445 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443218001446 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443218001447 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 443218001448 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 443218001449 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443218001450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443218001451 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443218001452 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443218001453 5S rRNA interface [nucleotide binding]; other site 443218001454 L27 interface [polypeptide binding]; other site 443218001455 23S rRNA interface [nucleotide binding]; other site 443218001456 L5 interface [polypeptide binding]; other site 443218001457 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443218001458 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443218001459 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443218001460 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443218001461 23S rRNA binding site [nucleotide binding]; other site 443218001462 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 443218001463 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443218001464 SecY translocase; Region: SecY; pfam00344 443218001465 adenylate kinase; Reviewed; Region: adk; PRK00279 443218001466 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443218001467 AMP-binding site [chemical binding]; other site 443218001468 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443218001469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218001470 active site 443218001471 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443218001472 rRNA binding site [nucleotide binding]; other site 443218001473 predicted 30S ribosome binding site; other site 443218001474 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 443218001475 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 443218001476 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 443218001477 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443218001478 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443218001479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218001480 RNA binding surface [nucleotide binding]; other site 443218001481 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443218001482 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443218001483 alphaNTD - beta interaction site [polypeptide binding]; other site 443218001484 alphaNTD homodimer interface [polypeptide binding]; other site 443218001485 alphaNTD - beta' interaction site [polypeptide binding]; other site 443218001486 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 443218001487 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 443218001488 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 443218001489 Protein of unknown function (DUF690); Region: DUF690; cl04939 443218001490 Predicted acyl esterases [General function prediction only]; Region: COG2936 443218001491 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 443218001492 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443218001493 Predicted membrane protein [Function unknown]; Region: COG4129 443218001494 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 443218001495 Cation efflux family; Region: Cation_efflux; cl00316 443218001496 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443218001497 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443218001498 GDP-binding site [chemical binding]; other site 443218001499 ACT binding site; other site 443218001500 IMP binding site; other site 443218001501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218001502 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218001503 Probable transposase; Region: OrfB_IS605; pfam01385 443218001504 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218001505 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 443218001506 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443218001507 catalytic residues [active] 443218001508 catalytic nucleophile [active] 443218001509 Transport protein; Region: actII; TIGR00833 443218001510 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443218001511 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443218001512 Ferredoxin [Energy production and conversion]; Region: COG1146 443218001513 4Fe-4S binding domain; Region: Fer4; cl02805 443218001514 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 443218001515 ferredoxin-NADP+ reductase; Region: PLN02852 443218001516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001517 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218001518 catalytic residues [active] 443218001519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218001520 Domain of unknown function (DUF368); Region: DUF368; cl00893 443218001521 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 443218001522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001523 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218001524 Protein of unknown function (DUF456); Region: DUF456; cl01069 443218001525 ferredoxin-NADP+ reductase; Region: PLN02852 443218001526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001527 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 443218001528 active site residue [active] 443218001529 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 443218001530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218001531 homodimer interface [polypeptide binding]; other site 443218001532 substrate-cofactor binding pocket; other site 443218001533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218001534 catalytic residue [active] 443218001535 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 443218001536 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218001537 phosphate acetyltransferase; Reviewed; Region: PRK05632 443218001538 DRTGG domain; Region: DRTGG; cl12147 443218001539 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 443218001540 Acetokinase family; Region: Acetate_kinase; cl01029 443218001541 acetate kinase; Region: ackA; TIGR00016 443218001542 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218001543 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218001544 active site 443218001545 ATP binding site [chemical binding]; other site 443218001546 substrate binding site [chemical binding]; other site 443218001547 activation loop (A-loop); other site 443218001548 Tetratricopeptide repeat; Region: TPR_16; pfam13432 443218001549 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 443218001550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218001551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218001552 substrate binding pocket [chemical binding]; other site 443218001553 membrane-bound complex binding site; other site 443218001554 hinge residues; other site 443218001555 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218001556 nudix motif; other site 443218001557 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443218001558 thiamine phosphate binding site [chemical binding]; other site 443218001559 active site 443218001560 pyrophosphate binding site [ion binding]; other site 443218001561 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443218001562 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 443218001563 thiS-thiF/thiG interaction site; other site 443218001564 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 443218001565 ThiS interaction site; other site 443218001566 putative active site [active] 443218001567 tetramer interface [polypeptide binding]; other site 443218001568 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218001569 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 443218001570 Walker A/P-loop; other site 443218001571 ATP binding site [chemical binding]; other site 443218001572 Q-loop/lid; other site 443218001573 ABC transporter signature motif; other site 443218001574 Walker B; other site 443218001575 D-loop; other site 443218001576 H-loop/switch region; other site 443218001577 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443218001578 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 443218001579 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 443218001580 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 443218001581 PA/protease or protease-like domain interface [polypeptide binding]; other site 443218001582 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 443218001583 active site 443218001584 metal binding site [ion binding]; metal-binding site 443218001585 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218001586 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218001587 siderophore binding site; other site 443218001588 cyclase homology domain; Region: CHD; cd07302 443218001589 nucleotidyl binding site; other site 443218001590 metal binding site [ion binding]; metal-binding site 443218001591 dimer interface [polypeptide binding]; other site 443218001592 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443218001593 dimer interface [polypeptide binding]; other site 443218001594 substrate binding site [chemical binding]; other site 443218001595 ATP binding site [chemical binding]; other site 443218001596 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 443218001597 ThiC-associated domain; Region: ThiC-associated; pfam13667 443218001598 ThiC family; Region: ThiC; cl08031 443218001599 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218001600 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443218001601 putative catalytic site [active] 443218001602 putative phosphate binding site [ion binding]; other site 443218001603 active site 443218001604 metal binding site A [ion binding]; metal-binding site 443218001605 DNA binding site [nucleotide binding] 443218001606 putative AP binding site [nucleotide binding]; other site 443218001607 putative metal binding site B [ion binding]; other site 443218001608 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443218001609 active site 443218001610 catalytic residues [active] 443218001611 metal binding site [ion binding]; metal-binding site 443218001612 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 443218001613 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218001614 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 443218001615 E-class dimer interface [polypeptide binding]; other site 443218001616 P-class dimer interface [polypeptide binding]; other site 443218001617 active site 443218001618 Cu2+ binding site [ion binding]; other site 443218001619 Zn2+ binding site [ion binding]; other site 443218001620 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218001621 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443218001622 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 443218001623 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 443218001624 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 443218001625 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 443218001626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218001627 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 443218001628 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 443218001629 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218001630 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218001631 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218001632 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 443218001633 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 443218001634 26S protease regulatory subunit 6B-like protein; Provisional; Region: PTZ00454 443218001635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001636 Walker A motif; other site 443218001637 ATP binding site [chemical binding]; other site 443218001638 Walker B motif; other site 443218001639 arginine finger; other site 443218001640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001641 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443218001642 Walker A motif; other site 443218001643 ATP binding site [chemical binding]; other site 443218001644 Walker B motif; other site 443218001645 arginine finger; other site 443218001646 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 443218001647 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218001648 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 443218001649 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443218001650 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443218001651 dimer interface [polypeptide binding]; other site 443218001652 putative functional site; other site 443218001653 putative MPT binding site; other site 443218001654 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218001655 Helix-turn-helix domains; Region: HTH; cl00088 443218001656 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218001657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001658 NAD(P) binding site [chemical binding]; other site 443218001659 active site 443218001660 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 443218001661 Helix-turn-helix domains; Region: HTH; cl00088 443218001662 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443218001663 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218001664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218001665 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443218001666 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 443218001667 active site 443218001668 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443218001669 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218001670 ring oligomerisation interface [polypeptide binding]; other site 443218001671 ATP/Mg binding site [chemical binding]; other site 443218001672 stacking interactions; other site 443218001673 hinge regions; other site 443218001674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218001675 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443218001676 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 443218001677 Gas vesicle protein; Region: Gas_vesicle; cl02954 443218001678 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 443218001679 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 443218001680 Gas vesicle protein; Region: Gas_vesicle; cl02954 443218001681 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 443218001682 Gas vesicle protein; Region: Gas_vesicle; cl02954 443218001683 Gas vesicle protein K; Region: GvpK; pfam05121 443218001684 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218001685 PHB binding site; other site 443218001686 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218001687 active site 443218001688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218001689 Helix-turn-helix domains; Region: HTH; cl00088 443218001690 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 443218001691 Amidase; Region: Amidase; cl11426 443218001692 Amidase; Region: Amidase; cl11426 443218001693 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 443218001694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218001696 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218001697 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218001698 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218001699 short chain dehydrogenase; Provisional; Region: PRK05872 443218001700 classical (c) SDRs; Region: SDR_c; cd05233 443218001701 NAD(P) binding site [chemical binding]; other site 443218001702 active site 443218001703 allophanate hydrolase; Region: allophanate_hyd; TIGR02713 443218001704 Amidase; Region: Amidase; cl11426 443218001705 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 443218001706 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 443218001707 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 443218001708 Walker A/P-loop; other site 443218001709 ATP binding site [chemical binding]; other site 443218001710 Q-loop/lid; other site 443218001711 ABC transporter signature motif; other site 443218001712 Walker B; other site 443218001713 D-loop; other site 443218001714 H-loop/switch region; other site 443218001715 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 443218001716 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 443218001717 Walker A/P-loop; other site 443218001718 ATP binding site [chemical binding]; other site 443218001719 Q-loop/lid; other site 443218001720 ABC transporter signature motif; other site 443218001721 Walker B; other site 443218001722 D-loop; other site 443218001723 H-loop/switch region; other site 443218001724 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218001725 TM-ABC transporter signature motif; other site 443218001726 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218001727 TM-ABC transporter signature motif; other site 443218001728 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218001729 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 443218001730 putative ligand binding site [chemical binding]; other site 443218001731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218001732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218001733 non-specific DNA binding site [nucleotide binding]; other site 443218001734 salt bridge; other site 443218001735 sequence-specific DNA binding site [nucleotide binding]; other site 443218001736 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 443218001737 Domain of unknown function (DUF955); Region: DUF955; cl01076 443218001738 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 443218001739 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443218001740 tetramer interface [polypeptide binding]; other site 443218001741 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 443218001742 active site 443218001743 Mg2+/Mn2+ binding site [ion binding]; other site 443218001744 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443218001745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001746 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218001747 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 443218001748 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 443218001749 THF binding site; other site 443218001750 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443218001751 substrate binding site [chemical binding]; other site 443218001752 THF binding site; other site 443218001753 zinc-binding site [ion binding]; other site 443218001754 Protein of unknown function (DUF445); Region: DUF445; pfam04286 443218001755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218001756 non-specific DNA binding site [nucleotide binding]; other site 443218001757 salt bridge; other site 443218001758 sequence-specific DNA binding site [nucleotide binding]; other site 443218001759 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 443218001760 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443218001761 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218001762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218001763 DNA binding residues [nucleotide binding] 443218001764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001766 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 443218001767 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443218001768 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443218001769 putative active site [active] 443218001770 putative substrate binding site [chemical binding]; other site 443218001771 putative cosubstrate binding site; other site 443218001772 catalytic site [active] 443218001773 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443218001774 intersubunit interface [polypeptide binding]; other site 443218001775 active site 443218001776 catalytic residue [active] 443218001777 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443218001778 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443218001779 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443218001780 FAD binding domain; Region: FAD_binding_4; pfam01565 443218001781 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443218001782 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001784 NAD(P) binding site [chemical binding]; other site 443218001785 active site 443218001786 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001787 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218001788 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443218001789 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 443218001790 putative ADP-binding pocket [chemical binding]; other site 443218001791 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 443218001792 4-coumarate--CoA ligase; Region: PLN02246 443218001793 AMP-binding enzyme; Region: AMP-binding; cl15778 443218001794 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218001795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218001796 catalytic core [active] 443218001797 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 443218001798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218001799 dimer interface [polypeptide binding]; other site 443218001800 phosphorylation site [posttranslational modification] 443218001801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218001802 ATP binding site [chemical binding]; other site 443218001803 Mg2+ binding site [ion binding]; other site 443218001804 G-X-G motif; other site 443218001805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218001806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218001807 active site 443218001808 phosphorylation site [posttranslational modification] 443218001809 intermolecular recognition site; other site 443218001810 dimerization interface [polypeptide binding]; other site 443218001811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218001812 DNA binding site [nucleotide binding] 443218001813 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 443218001814 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218001815 active site 443218001816 catalytic site [active] 443218001817 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443218001818 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218001819 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443218001820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001821 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218001822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443218001823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218001824 NAD(P) binding site [chemical binding]; other site 443218001825 active site 443218001826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218001827 putative acyl-acceptor binding pocket; other site 443218001828 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218001829 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218001830 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218001831 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 443218001832 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 443218001833 tRNA; other site 443218001834 putative tRNA binding site [nucleotide binding]; other site 443218001835 putative NADP binding site [chemical binding]; other site 443218001836 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443218001837 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 443218001838 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443218001839 domain interfaces; other site 443218001840 active site 443218001841 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218001842 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218001843 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443218001844 active site 443218001845 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 443218001846 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443218001847 dimer interface [polypeptide binding]; other site 443218001848 active site 443218001849 Schiff base residues; other site 443218001850 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 443218001851 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 443218001852 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 443218001853 LamB/YcsF family; Region: LamB_YcsF; cl00664 443218001854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218001855 dimer interface [polypeptide binding]; other site 443218001856 putative PBP binding regions; other site 443218001857 ABC-ATPase subunit interface; other site 443218001858 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218001859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218001860 Walker A/P-loop; other site 443218001861 ATP binding site [chemical binding]; other site 443218001862 Q-loop/lid; other site 443218001863 ABC transporter signature motif; other site 443218001864 Walker B; other site 443218001865 D-loop; other site 443218001866 H-loop/switch region; other site 443218001867 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218001868 intersubunit interface [polypeptide binding]; other site 443218001869 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218001870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218001871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218001872 DNA binding site [nucleotide binding] 443218001873 domain linker motif; other site 443218001874 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 443218001875 putative dimerization interface [polypeptide binding]; other site 443218001876 putative ligand binding site [chemical binding]; other site 443218001877 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 443218001878 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218001879 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218001880 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218001881 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 443218001882 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443218001883 active site 443218001884 homotetramer interface [polypeptide binding]; other site 443218001885 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218001886 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218001887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218001888 Walker A/P-loop; other site 443218001889 ATP binding site [chemical binding]; other site 443218001890 Q-loop/lid; other site 443218001891 ABC transporter signature motif; other site 443218001892 Walker B; other site 443218001893 D-loop; other site 443218001894 H-loop/switch region; other site 443218001895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218001896 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218001897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218001898 Walker A/P-loop; other site 443218001899 ATP binding site [chemical binding]; other site 443218001900 Q-loop/lid; other site 443218001901 ABC transporter signature motif; other site 443218001902 Walker B; other site 443218001903 D-loop; other site 443218001904 H-loop/switch region; other site 443218001905 MbtH-like protein; Region: MbtH; cl01279 443218001906 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 443218001907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 443218001908 Dienelactone hydrolase family; Region: DLH; pfam01738 443218001909 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001910 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443218001911 nucleotide binding site/active site [active] 443218001912 HIT family signature motif; other site 443218001913 catalytic residue [active] 443218001914 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443218001915 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443218001916 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218001917 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443218001918 aspartate aminotransferase; Provisional; Region: PRK05764 443218001919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218001920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218001921 homodimer interface [polypeptide binding]; other site 443218001922 catalytic residue [active] 443218001923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443218001924 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443218001925 synthetase active site [active] 443218001926 NTP binding site [chemical binding]; other site 443218001927 metal binding site [ion binding]; metal-binding site 443218001928 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 443218001929 Lyase; Region: Lyase_1; pfam00206 443218001930 tetramer interface [polypeptide binding]; other site 443218001931 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443218001932 HIT family signature motif; other site 443218001933 catalytic residue [active] 443218001934 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443218001935 active site 443218001936 ATP binding site [chemical binding]; other site 443218001937 substrate binding site [chemical binding]; other site 443218001938 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443218001939 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218001940 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 443218001941 catalytic residues [active] 443218001942 dimer interface [polypeptide binding]; other site 443218001943 Predicted deacetylase [General function prediction only]; Region: COG3233 443218001944 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 443218001945 putative active site [active] 443218001946 putative Zn binding site [ion binding]; other site 443218001947 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443218001948 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 443218001949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218001950 Walker A/P-loop; other site 443218001951 ATP binding site [chemical binding]; other site 443218001952 Q-loop/lid; other site 443218001953 ABC transporter signature motif; other site 443218001954 Walker B; other site 443218001955 D-loop; other site 443218001956 H-loop/switch region; other site 443218001957 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443218001958 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443218001959 FtsX-like permease family; Region: FtsX; cl15850 443218001960 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 443218001961 FtsX-like permease family; Region: FtsX; cl15850 443218001962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218001963 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 443218001964 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443218001965 putative active site [active] 443218001966 catalytic triad [active] 443218001967 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218001968 OpgC protein; Region: OpgC_C; cl00792 443218001969 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218001970 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218001971 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218001972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218001973 Walker A motif; other site 443218001974 ATP binding site [chemical binding]; other site 443218001975 Walker B motif; other site 443218001976 arginine finger; other site 443218001977 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443218001978 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443218001979 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443218001980 dimerization interface [polypeptide binding]; other site 443218001981 ATP binding site [chemical binding]; other site 443218001982 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443218001983 dimerization interface [polypeptide binding]; other site 443218001984 ATP binding site [chemical binding]; other site 443218001985 Predicted membrane protein [Function unknown]; Region: COG4425 443218001986 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218001987 CAAX protease self-immunity; Region: Abi; cl00558 443218001988 amidophosphoribosyltransferase; Provisional; Region: PRK07847 443218001989 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443218001990 active site 443218001991 tetramer interface [polypeptide binding]; other site 443218001992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218001993 active site 443218001994 short chain dehydrogenase; Provisional; Region: PRK06197 443218001995 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218001996 putative NAD(P) binding site [chemical binding]; other site 443218001997 active site 443218001998 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 443218001999 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443218002000 dimerization interface [polypeptide binding]; other site 443218002001 putative ATP binding site [chemical binding]; other site 443218002002 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 443218002003 L-asparaginase II; Region: Asparaginase_II; cl01842 443218002004 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443218002005 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443218002006 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002007 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 443218002008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218002009 catalytic residue [active] 443218002010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002011 Helix-turn-helix domains; Region: HTH; cl00088 443218002012 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218002014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218002015 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 443218002016 active site 443218002017 catalytic residues [active] 443218002018 metal binding site [ion binding]; metal-binding site 443218002019 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218002020 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218002021 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 443218002022 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 443218002023 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443218002024 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443218002025 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218002026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002027 Walker A/P-loop; other site 443218002028 ATP binding site [chemical binding]; other site 443218002029 ABC transporter; Region: ABC_tran; pfam00005 443218002030 Q-loop/lid; other site 443218002031 ABC transporter signature motif; other site 443218002032 Walker B; other site 443218002033 D-loop; other site 443218002034 H-loop/switch region; other site 443218002035 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443218002036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002037 Walker A/P-loop; other site 443218002038 ATP binding site [chemical binding]; other site 443218002039 Q-loop/lid; other site 443218002040 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 443218002041 elongation factor G; Reviewed; Region: PRK12740 443218002042 G1 box; other site 443218002043 putative GEF interaction site [polypeptide binding]; other site 443218002044 GTP/Mg2+ binding site [chemical binding]; other site 443218002045 Switch I region; other site 443218002046 G2 box; other site 443218002047 G3 box; other site 443218002048 Switch II region; other site 443218002049 G4 box; other site 443218002050 G5 box; other site 443218002051 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443218002052 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443218002053 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443218002054 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218002055 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218002056 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 443218002057 NAD(P) binding site [chemical binding]; other site 443218002058 catalytic residues [active] 443218002059 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218002060 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218002061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218002062 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218002063 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218002064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002065 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218002066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002067 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218002068 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218002069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002071 active site 443218002072 enoyl-CoA hydratase; Provisional; Region: PRK08260 443218002073 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002074 substrate binding site [chemical binding]; other site 443218002075 oxyanion hole (OAH) forming residues; other site 443218002076 trimer interface [polypeptide binding]; other site 443218002077 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443218002078 Helix-turn-helix domains; Region: HTH; cl00088 443218002079 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218002080 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002081 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002082 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218002083 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443218002084 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443218002085 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218002086 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218002087 FMN-binding pocket [chemical binding]; other site 443218002088 flavin binding motif; other site 443218002089 phosphate binding motif [ion binding]; other site 443218002090 beta-alpha-beta structure motif; other site 443218002091 NAD binding pocket [chemical binding]; other site 443218002092 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002093 catalytic loop [active] 443218002094 iron binding site [ion binding]; other site 443218002095 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218002096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002097 short chain dehydrogenase; Provisional; Region: PRK05872 443218002098 classical (c) SDRs; Region: SDR_c; cd05233 443218002099 NAD(P) binding site [chemical binding]; other site 443218002100 active site 443218002101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 443218002102 SEC-C motif; Region: SEC-C; pfam02810 443218002103 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 443218002104 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218002105 classical (c) SDRs; Region: SDR_c; cd05233 443218002106 NAD(P) binding site [chemical binding]; other site 443218002107 active site 443218002108 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 443218002109 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443218002110 heme-binding site [chemical binding]; other site 443218002111 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 443218002112 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443218002113 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443218002114 active site residue [active] 443218002115 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443218002116 active site residue [active] 443218002117 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 443218002118 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218002119 catalytic residues [active] 443218002120 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443218002121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218002122 DNA binding site [nucleotide binding] 443218002123 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 443218002124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218002125 Coenzyme A binding pocket [chemical binding]; other site 443218002126 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218002127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218002128 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443218002129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002130 dimer interface [polypeptide binding]; other site 443218002131 conserved gate region; other site 443218002132 putative PBP binding loops; other site 443218002133 ABC-ATPase subunit interface; other site 443218002134 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 443218002135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002136 dimer interface [polypeptide binding]; other site 443218002137 conserved gate region; other site 443218002138 putative PBP binding loops; other site 443218002139 ABC-ATPase subunit interface; other site 443218002140 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443218002141 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 443218002142 Walker A/P-loop; other site 443218002143 ATP binding site [chemical binding]; other site 443218002144 Q-loop/lid; other site 443218002145 ABC transporter signature motif; other site 443218002146 Walker B; other site 443218002147 D-loop; other site 443218002148 H-loop/switch region; other site 443218002149 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443218002150 PhoU domain; Region: PhoU; pfam01895 443218002151 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 443218002152 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218002153 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443218002154 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443218002155 FMN binding site [chemical binding]; other site 443218002156 active site 443218002157 catalytic residues [active] 443218002158 substrate binding site [chemical binding]; other site 443218002159 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218002160 Helix-turn-helix domains; Region: HTH; cl00088 443218002161 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443218002162 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218002163 FMN binding site [chemical binding]; other site 443218002164 substrate binding site [chemical binding]; other site 443218002165 putative catalytic residue [active] 443218002166 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002168 active site 443218002169 acyl-CoA synthetase; Validated; Region: PRK08316 443218002170 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218002172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002174 active site 443218002175 lipid-transfer protein; Provisional; Region: PRK08256 443218002176 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002177 active site 443218002178 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 443218002179 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443218002180 Helix-turn-helix domains; Region: HTH; cl00088 443218002181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218002182 classical (c) SDRs; Region: SDR_c; cd05233 443218002183 NAD(P) binding site [chemical binding]; other site 443218002184 active site 443218002185 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 443218002186 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218002188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218002189 classical (c) SDRs; Region: SDR_c; cd05233 443218002190 NAD(P) binding site [chemical binding]; other site 443218002191 active site 443218002192 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218002193 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002194 substrate binding site [chemical binding]; other site 443218002195 oxyanion hole (OAH) forming residues; other site 443218002196 trimer interface [polypeptide binding]; other site 443218002197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218002198 Predicted helicase [General function prediction only]; Region: COG4889 443218002199 short chain dehydrogenase; Provisional; Region: PRK07832 443218002200 classical (c) SDRs; Region: SDR_c; cd05233 443218002201 NAD(P) binding site [chemical binding]; other site 443218002202 active site 443218002203 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443218002204 active site 443218002205 catalytic triad [active] 443218002206 oxyanion hole [active] 443218002207 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218002208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218002209 putative NAD(P) binding site [chemical binding]; other site 443218002210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002211 Helix-turn-helix domains; Region: HTH; cl00088 443218002212 Winged helix-turn helix; Region: HTH_29; pfam13551 443218002213 Helix-turn-helix domains; Region: HTH; cl00088 443218002214 Integrase core domain; Region: rve; cl01316 443218002215 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218002216 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218002217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218002218 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002220 GAF domain; Region: GAF_2; pfam13185 443218002221 GAF domain; Region: GAF; cl15785 443218002222 transcriptional regulator NarL; Provisional; Region: PRK10651 443218002223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218002224 dimerization interface [polypeptide binding]; other site 443218002225 DNA binding residues [nucleotide binding] 443218002226 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218002227 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218002228 NAD(P) binding site [chemical binding]; other site 443218002229 catalytic residues [active] 443218002230 short chain dehydrogenase; Provisional; Region: PRK06197 443218002231 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218002232 putative NAD(P) binding site [chemical binding]; other site 443218002233 active site 443218002234 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 443218002235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218002236 active site 443218002237 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218002238 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218002239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218002240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002242 active site 443218002243 aminotransferase; Validated; Region: PRK07777 443218002244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218002245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218002246 homodimer interface [polypeptide binding]; other site 443218002247 catalytic residue [active] 443218002248 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443218002249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002250 dimer interface [polypeptide binding]; other site 443218002251 active site 443218002252 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443218002253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002254 substrate binding site [chemical binding]; other site 443218002255 oxyanion hole (OAH) forming residues; other site 443218002256 trimer interface [polypeptide binding]; other site 443218002257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002258 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218002259 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 443218002260 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 443218002261 Membrane transport protein; Region: Mem_trans; cl09117 443218002262 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443218002263 Helix-turn-helix domains; Region: HTH; cl00088 443218002264 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218002265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002266 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218002267 Walker A/P-loop; other site 443218002268 ATP binding site [chemical binding]; other site 443218002269 Q-loop/lid; other site 443218002270 ABC transporter signature motif; other site 443218002271 Walker B; other site 443218002272 D-loop; other site 443218002273 H-loop/switch region; other site 443218002274 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218002275 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443218002276 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 443218002277 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002278 Predicted esterase [General function prediction only]; Region: COG0627 443218002279 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 443218002280 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 443218002281 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 443218002282 Walker A/P-loop; other site 443218002283 ATP binding site [chemical binding]; other site 443218002284 Q-loop/lid; other site 443218002285 ABC transporter signature motif; other site 443218002286 Walker B; other site 443218002287 D-loop; other site 443218002288 H-loop/switch region; other site 443218002289 Helix-turn-helix domains; Region: HTH; cl00088 443218002290 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218002291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002292 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218002293 Walker A/P-loop; other site 443218002294 ATP binding site [chemical binding]; other site 443218002295 Q-loop/lid; other site 443218002296 ABC transporter signature motif; other site 443218002297 Walker B; other site 443218002298 D-loop; other site 443218002299 H-loop/switch region; other site 443218002300 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218002301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002302 Helix-turn-helix domains; Region: HTH; cl00088 443218002303 WHG domain; Region: WHG; pfam13305 443218002304 short chain dehydrogenase; Provisional; Region: PRK06197 443218002305 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218002306 putative NAD(P) binding site [chemical binding]; other site 443218002307 active site 443218002308 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218002309 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218002310 putative di-iron ligands [ion binding]; other site 443218002311 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218002312 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218002313 FAD binding pocket [chemical binding]; other site 443218002314 FAD binding motif [chemical binding]; other site 443218002315 phosphate binding motif [ion binding]; other site 443218002316 beta-alpha-beta structure motif; other site 443218002317 NAD binding pocket [chemical binding]; other site 443218002318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002319 catalytic loop [active] 443218002320 iron binding site [ion binding]; other site 443218002321 GTPase RsgA; Reviewed; Region: PRK01889 443218002322 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443218002323 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443218002324 GTP/Mg2+ binding site [chemical binding]; other site 443218002325 G4 box; other site 443218002326 G5 box; other site 443218002327 G1 box; other site 443218002328 Switch I region; other site 443218002329 G2 box; other site 443218002330 G3 box; other site 443218002331 Switch II region; other site 443218002332 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443218002333 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443218002334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218002336 ATP binding site [chemical binding]; other site 443218002337 putative Mg++ binding site [ion binding]; other site 443218002338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218002339 nucleotide binding region [chemical binding]; other site 443218002340 ATP-binding site [chemical binding]; other site 443218002341 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 443218002342 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 443218002343 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002344 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218002345 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443218002346 WYL domain; Region: WYL; cl14852 443218002347 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 443218002348 trimer interface [polypeptide binding]; other site 443218002349 dimer interface [polypeptide binding]; other site 443218002350 putative active site [active] 443218002351 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443218002352 MPT binding site; other site 443218002353 trimer interface [polypeptide binding]; other site 443218002354 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443218002355 MoaD interaction [polypeptide binding]; other site 443218002356 active site residues [active] 443218002357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 443218002358 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 443218002359 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218002360 anti sigma factor interaction site; other site 443218002361 regulatory phosphorylation site [posttranslational modification]; other site 443218002362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 443218002363 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 443218002364 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 443218002365 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 443218002366 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 443218002367 MoaE interaction surface [polypeptide binding]; other site 443218002368 MoeB interaction surface [polypeptide binding]; other site 443218002369 thiocarboxylated glycine; other site 443218002370 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443218002371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218002372 FeS/SAM binding site; other site 443218002373 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443218002374 hypothetical protein; Provisional; Region: PRK11770 443218002375 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443218002376 Domain of unknown function (DUF307); Region: DUF307; pfam03733 443218002377 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 443218002378 DNA-binding site [nucleotide binding]; DNA binding site 443218002379 RNA-binding motif; other site 443218002380 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 443218002381 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 443218002382 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443218002383 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443218002384 active site 443218002385 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 443218002386 Helix-turn-helix domains; Region: HTH; cl00088 443218002387 hypothetical protein; Provisional; Region: PRK01346 443218002388 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218002389 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218002390 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 443218002391 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 443218002392 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443218002393 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218002394 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 443218002395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218002396 catalytic residue [active] 443218002397 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 443218002398 Citrate synthase; Region: Citrate_synt; pfam00285 443218002399 oxalacetate binding site [chemical binding]; other site 443218002400 citrylCoA binding site [chemical binding]; other site 443218002401 coenzyme A binding site [chemical binding]; other site 443218002402 catalytic triad [active] 443218002403 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 443218002404 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218002405 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443218002406 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443218002407 dimer interface [polypeptide binding]; other site 443218002408 Citrate synthase; Region: Citrate_synt; pfam00285 443218002409 active site 443218002410 citrylCoA binding site [chemical binding]; other site 443218002411 NADH binding [chemical binding]; other site 443218002412 cationic pore residues; other site 443218002413 oxalacetate/citrate binding site [chemical binding]; other site 443218002414 coenzyme A binding site [chemical binding]; other site 443218002415 catalytic triad [active] 443218002416 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 443218002417 Predicted membrane protein [Function unknown]; Region: COG1511 443218002418 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218002419 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 443218002420 DNA photolyase; Region: DNA_photolyase; pfam00875 443218002421 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 443218002422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218002423 S-adenosylmethionine binding site [chemical binding]; other site 443218002424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218002425 dimer interface [polypeptide binding]; other site 443218002426 phosphorylation site [posttranslational modification] 443218002427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218002428 ATP binding site [chemical binding]; other site 443218002429 Mg2+ binding site [ion binding]; other site 443218002430 G-X-G motif; other site 443218002431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218002432 active site 443218002433 phosphorylation site [posttranslational modification] 443218002434 intermolecular recognition site; other site 443218002435 dimerization interface [polypeptide binding]; other site 443218002436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218002437 DNA binding site [nucleotide binding] 443218002438 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 443218002439 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218002440 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218002441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218002442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218002443 active site 443218002444 catalytic tetrad [active] 443218002445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002446 substrate binding site [chemical binding]; other site 443218002447 oxyanion hole (OAH) forming residues; other site 443218002448 trimer interface [polypeptide binding]; other site 443218002449 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218002450 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218002451 Protein of unknown function, DUF393; Region: DUF393; cl01136 443218002452 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 443218002453 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218002454 Permease; Region: Permease; cl00510 443218002455 Permease; Region: Permease; cl00510 443218002456 mce related protein; Region: MCE; pfam02470 443218002457 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002458 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002459 mce related protein; Region: MCE; pfam02470 443218002460 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002461 mce related protein; Region: MCE; pfam02470 443218002462 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002463 mce related protein; Region: MCE; pfam02470 443218002464 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002465 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002466 mce related protein; Region: MCE; pfam02470 443218002467 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002468 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218002469 mce related protein; Region: MCE; pfam02470 443218002470 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 443218002471 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 443218002472 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 443218002473 Histidine kinase; Region: His_kinase; pfam06580 443218002474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218002475 ATP binding site [chemical binding]; other site 443218002476 Mg2+ binding site [ion binding]; other site 443218002477 G-X-G motif; other site 443218002478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218002479 active site 443218002480 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443218002481 substrate binding site; other site 443218002482 dimer interface; other site 443218002483 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 443218002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218002485 active site 443218002486 phosphorylation site [posttranslational modification] 443218002487 intermolecular recognition site; other site 443218002488 dimerization interface [polypeptide binding]; other site 443218002489 LytTr DNA-binding domain; Region: LytTR; cl04498 443218002490 Sodium:solute symporter family; Region: SSF; cl00456 443218002491 Sodium:solute symporter family; Region: SSF; cl00456 443218002492 Protein of unknown function, DUF485; Region: DUF485; cl01231 443218002493 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218002494 Sodium:solute symporter family; Region: SSF; cl00456 443218002495 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443218002496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002497 substrate binding pocket [chemical binding]; other site 443218002498 catalytic triad [active] 443218002499 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218002500 hydrophobic ligand binding site; other site 443218002501 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002502 mce related protein; Region: MCE; pfam02470 443218002503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002504 mce related protein; Region: MCE; pfam02470 443218002505 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002507 mce related protein; Region: MCE; pfam02470 443218002508 mce related protein; Region: MCE; pfam02470 443218002509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218002511 mce related protein; Region: MCE; pfam02470 443218002512 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218002513 mce related protein; Region: MCE; pfam02470 443218002514 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 443218002515 Permease; Region: Permease; cl00510 443218002516 Permease; Region: Permease; cl00510 443218002517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002518 Helix-turn-helix domains; Region: HTH; cl00088 443218002519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002520 active site 443218002521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002523 active site 443218002524 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218002525 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218002526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218002527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002528 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002530 active site 443218002531 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002533 active site 443218002534 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218002535 active site 443218002536 catalytic site [active] 443218002537 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002538 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002539 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 443218002540 putative active site [active] 443218002541 putative catalytic site [active] 443218002542 lipid-transfer protein; Provisional; Region: PRK07855 443218002543 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002544 active site 443218002545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218002546 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218002547 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218002548 active site 443218002549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002550 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 443218002551 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218002552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218002553 DNA binding residues [nucleotide binding] 443218002554 dimerization interface [polypeptide binding]; other site 443218002555 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 443218002556 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 443218002557 catalytic residues [active] 443218002558 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218002559 benzoate transport; Region: 2A0115; TIGR00895 443218002560 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443218002561 enoyl-CoA hydratase; Region: PLN02864 443218002562 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218002563 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 443218002564 dimer interaction site [polypeptide binding]; other site 443218002565 substrate-binding tunnel; other site 443218002566 active site 443218002567 catalytic site [active] 443218002568 substrate binding site [chemical binding]; other site 443218002569 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218002570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218002571 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218002572 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218002573 FAD binding pocket [chemical binding]; other site 443218002574 FAD binding motif [chemical binding]; other site 443218002575 phosphate binding motif [ion binding]; other site 443218002576 beta-alpha-beta structure motif; other site 443218002577 NAD(p) ribose binding residues [chemical binding]; other site 443218002578 NAD binding pocket [chemical binding]; other site 443218002579 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218002580 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218002581 catalytic loop [active] 443218002582 iron binding site [ion binding]; other site 443218002583 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218002584 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 443218002585 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218002586 hydrophobic ligand binding site; other site 443218002587 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 443218002588 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002589 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 443218002590 Flavin binding site [chemical binding]; other site 443218002591 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 443218002592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002593 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443218002594 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 443218002595 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 443218002596 active site 443218002597 Fe binding site [ion binding]; other site 443218002598 Flavin Reductases; Region: FlaRed; cl00801 443218002599 short chain dehydrogenase; Provisional; Region: PRK06179 443218002600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002601 NAD(P) binding site [chemical binding]; other site 443218002602 active site 443218002603 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 443218002604 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 443218002605 putative molybdopterin cofactor binding site [chemical binding]; other site 443218002606 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 443218002607 putative molybdopterin cofactor binding site; other site 443218002608 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 443218002609 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 443218002610 Helix-turn-helix domains; Region: HTH; cl00088 443218002611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443218002612 dimerization interface [polypeptide binding]; other site 443218002613 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218002614 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218002615 acyl-CoA synthetase; Validated; Region: PRK06188 443218002616 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002617 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002618 lipid-transfer protein; Provisional; Region: PRK08256 443218002619 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002620 active site 443218002621 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443218002622 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002623 active site 443218002624 lipid-transfer protein; Provisional; Region: PRK07937 443218002625 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443218002626 active site 443218002627 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002628 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443218002629 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002630 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002631 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002632 short chain dehydrogenase; Provisional; Region: PRK07825 443218002633 classical (c) SDRs; Region: SDR_c; cd05233 443218002634 NAD(P) binding site [chemical binding]; other site 443218002635 active site 443218002636 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 443218002637 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002638 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218002639 active site 443218002640 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002643 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002644 active site 443218002645 enoyl-CoA hydratase; Provisional; Region: PRK08290 443218002646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002647 substrate binding site [chemical binding]; other site 443218002648 oxyanion hole (OAH) forming residues; other site 443218002649 trimer interface [polypeptide binding]; other site 443218002650 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443218002651 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002652 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218002653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218002654 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 443218002655 active site 443218002656 short chain dehydrogenase; Provisional; Region: PRK07831 443218002657 classical (c) SDRs; Region: SDR_c; cd05233 443218002658 NAD(P) binding site [chemical binding]; other site 443218002659 active site 443218002660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002661 Helix-turn-helix domains; Region: HTH; cl00088 443218002662 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 443218002663 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002664 dimer interface [polypeptide binding]; other site 443218002665 active site 443218002666 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218002667 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218002668 Walker A/P-loop; other site 443218002669 ATP binding site [chemical binding]; other site 443218002670 Q-loop/lid; other site 443218002671 ABC transporter signature motif; other site 443218002672 Walker B; other site 443218002673 D-loop; other site 443218002674 H-loop/switch region; other site 443218002675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002677 dimer interface [polypeptide binding]; other site 443218002678 conserved gate region; other site 443218002679 putative PBP binding loops; other site 443218002680 ABC-ATPase subunit interface; other site 443218002681 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 443218002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218002683 dimer interface [polypeptide binding]; other site 443218002684 conserved gate region; other site 443218002685 putative PBP binding loops; other site 443218002686 ABC-ATPase subunit interface; other site 443218002687 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218002688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218002689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218002690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218002691 DNA binding site [nucleotide binding] 443218002692 domain linker motif; other site 443218002693 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218002694 ligand binding site [chemical binding]; other site 443218002695 dimerization interface [polypeptide binding]; other site 443218002696 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 443218002697 dimer interface [polypeptide binding]; other site 443218002698 active site/substrate binding site [active] 443218002699 Nitronate monooxygenase; Region: NMO; pfam03060 443218002700 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218002701 FMN binding site [chemical binding]; other site 443218002702 substrate binding site [chemical binding]; other site 443218002703 putative catalytic residue [active] 443218002704 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218002705 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218002706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002707 enoyl-CoA hydratase; Provisional; Region: PRK06495 443218002708 substrate binding site [chemical binding]; other site 443218002709 oxyanion hole (OAH) forming residues; other site 443218002710 trimer interface [polypeptide binding]; other site 443218002711 short chain dehydrogenase; Provisional; Region: PRK07856 443218002712 classical (c) SDRs; Region: SDR_c; cd05233 443218002713 NAD(P) binding site [chemical binding]; other site 443218002714 active site 443218002715 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 443218002716 homodimer interface [polypeptide binding]; other site 443218002717 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 443218002718 NAD binding site [chemical binding]; other site 443218002719 active site 443218002720 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 443218002721 active site 443218002722 FMN binding site [chemical binding]; other site 443218002723 substrate binding site [chemical binding]; other site 443218002724 putative catalytic residue [active] 443218002725 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218002726 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 443218002727 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218002728 dimer interface [polypeptide binding]; other site 443218002729 active site 443218002730 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218002731 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218002732 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443218002733 [2Fe-2S] cluster binding site [ion binding]; other site 443218002734 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 443218002735 putative alpha subunit interface [polypeptide binding]; other site 443218002736 putative active site [active] 443218002737 putative substrate binding site [chemical binding]; other site 443218002738 Fe binding site [ion binding]; other site 443218002739 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218002740 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218002741 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218002742 homodimer interface [polypeptide binding]; other site 443218002743 NADP binding site [chemical binding]; other site 443218002744 substrate binding site [chemical binding]; other site 443218002745 FAD dependent oxidoreductase; Region: DAO; pfam01266 443218002746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002747 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 443218002748 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 443218002749 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443218002751 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443218002752 glutamine binding [chemical binding]; other site 443218002753 catalytic triad [active] 443218002754 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 443218002755 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443218002756 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218002757 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 443218002758 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218002759 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218002760 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 443218002761 FAD binding site [chemical binding]; other site 443218002762 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218002763 substrate binding pocket [chemical binding]; other site 443218002764 inhibitor binding site; inhibition site 443218002765 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218002766 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218002767 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218002768 homodimer interface [polypeptide binding]; other site 443218002769 NADP binding site [chemical binding]; other site 443218002770 substrate binding site [chemical binding]; other site 443218002771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218002772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218002773 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 443218002774 [2Fe-2S] cluster binding site [ion binding]; other site 443218002775 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218002776 Helix-turn-helix domains; Region: HTH; cl00088 443218002777 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218002778 BCCT family transporter; Region: BCCT; cl00569 443218002779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218002780 dimerization interface [polypeptide binding]; other site 443218002781 putative DNA binding site [nucleotide binding]; other site 443218002782 putative Zn2+ binding site [ion binding]; other site 443218002783 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 443218002784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218002785 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218002786 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218002787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218002788 Helix-turn-helix domains; Region: HTH; cl00088 443218002789 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 443218002790 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002791 active site 443218002792 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218002793 lipid-transfer protein; Provisional; Region: PRK07937 443218002794 active site 443218002795 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002796 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002797 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 443218002798 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 443218002799 DUF35 OB-fold domain; Region: DUF35; pfam01796 443218002800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218002801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218002802 enoyl-CoA hydratase; Provisional; Region: PRK07799 443218002803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218002804 substrate binding site [chemical binding]; other site 443218002805 oxyanion hole (OAH) forming residues; other site 443218002806 trimer interface [polypeptide binding]; other site 443218002807 acyl-CoA synthetase; Validated; Region: PRK07798 443218002808 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002809 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002810 Nitronate monooxygenase; Region: NMO; pfam03060 443218002811 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218002812 FMN binding site [chemical binding]; other site 443218002813 substrate binding site [chemical binding]; other site 443218002814 putative catalytic residue [active] 443218002815 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 443218002816 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218002817 NAD binding site [chemical binding]; other site 443218002818 catalytic residues [active] 443218002819 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218002820 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443218002821 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443218002822 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 443218002823 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443218002824 lipoyl attachment site [posttranslational modification]; other site 443218002825 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 443218002826 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 443218002827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 443218002828 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443218002829 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002830 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 443218002831 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 443218002832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002833 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218002834 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218002835 dimer interface [polypeptide binding]; other site 443218002836 active site 443218002837 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218002838 folate binding site [chemical binding]; other site 443218002839 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218002840 Helix-turn-helix domains; Region: HTH; cl00088 443218002841 FCD domain; Region: FCD; cl11656 443218002842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218002843 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 443218002844 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443218002845 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443218002846 putative active site [active] 443218002847 putative substrate binding site [chemical binding]; other site 443218002848 putative cosubstrate binding site; other site 443218002849 catalytic site [active] 443218002850 FAD dependent oxidoreductase; Region: DAO; pfam01266 443218002851 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 443218002852 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218002853 Helix-turn-helix domains; Region: HTH; cl00088 443218002854 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218002855 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218002856 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218002857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218002859 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 443218002860 [2Fe-2S] cluster binding site [ion binding]; other site 443218002861 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218002862 Helix-turn-helix domains; Region: HTH; cl00088 443218002863 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218002864 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 443218002865 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 443218002866 [2Fe-2S] cluster binding site [ion binding]; other site 443218002867 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218002868 hydrophobic ligand binding site; other site 443218002869 BCCT family transporter; Region: BCCT; cl00569 443218002870 choline dehydrogenase; Validated; Region: PRK02106 443218002871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002872 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218002873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002874 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 443218002875 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218002876 active site 443218002877 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218002878 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 443218002879 FAD binding site [chemical binding]; other site 443218002880 substrate binding site [chemical binding]; other site 443218002881 catalytic base [active] 443218002882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002883 NAD(P) binding site [chemical binding]; other site 443218002884 active site 443218002885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218002886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002887 NAD(P) binding site [chemical binding]; other site 443218002888 active site 443218002889 hypothetical protein; Validated; Region: PRK07121 443218002890 acetaldehyde dehydrogenase; Validated; Region: PRK08300 443218002891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002892 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 443218002893 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 443218002894 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 443218002895 active site 443218002896 catalytic residues [active] 443218002897 metal binding site [ion binding]; metal-binding site 443218002898 DmpG-like communication domain; Region: DmpG_comm; pfam07836 443218002899 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 443218002900 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443218002901 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218002902 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443218002903 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 443218002904 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218002905 dimer interface [polypeptide binding]; other site 443218002906 PYR/PP interface [polypeptide binding]; other site 443218002907 TPP binding site [chemical binding]; other site 443218002908 substrate binding site [chemical binding]; other site 443218002909 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 443218002910 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 443218002911 TPP-binding site [chemical binding]; other site 443218002912 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 443218002913 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218002914 Helix-turn-helix domains; Region: HTH; cl00088 443218002915 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 443218002916 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218002917 dimer interface [polypeptide binding]; other site 443218002918 PYR/PP interface [polypeptide binding]; other site 443218002919 TPP binding site [chemical binding]; other site 443218002920 substrate binding site [chemical binding]; other site 443218002921 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443218002922 TPP-binding site; other site 443218002923 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443218002924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218002925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218002926 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218002927 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 443218002928 Phosphoesterase family; Region: Phosphoesterase; cl15450 443218002929 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218002930 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218002931 putative active site [active] 443218002932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 443218002933 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 443218002934 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443218002935 catalytic site [active] 443218002936 putative active site [active] 443218002937 putative substrate binding site [chemical binding]; other site 443218002938 dimer interface [polypeptide binding]; other site 443218002939 acyl-CoA synthetase; Validated; Region: PRK07788 443218002940 AMP-binding enzyme; Region: AMP-binding; cl15778 443218002941 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218002942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002943 NAD(P) binding site [chemical binding]; other site 443218002944 active site 443218002945 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 443218002946 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218002947 catalytic Zn binding site [ion binding]; other site 443218002948 NAD(P) binding site [chemical binding]; other site 443218002949 structural Zn binding site [ion binding]; other site 443218002950 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 443218002951 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443218002952 active site 443218002953 FMN binding site [chemical binding]; other site 443218002954 2,4-decadienoyl-CoA binding site; other site 443218002955 catalytic residue [active] 443218002956 4Fe-4S cluster binding site [ion binding]; other site 443218002957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218002958 Helix-turn-helix domains; Region: HTH; cl00088 443218002959 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218002960 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 443218002961 putative ADP-ribose binding site [chemical binding]; other site 443218002962 putative active site [active] 443218002963 Fasciclin domain; Region: Fasciclin; cl02663 443218002964 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 443218002965 Moco binding site; other site 443218002966 metal coordination site [ion binding]; other site 443218002967 dimerization interface [polypeptide binding]; other site 443218002968 Putative zinc-finger; Region: zf-HC2; cl15806 443218002969 putative anti-sigmaE protein; Provisional; Region: PRK13920 443218002970 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443218002971 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443218002972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218002973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218002974 DNA binding residues [nucleotide binding] 443218002975 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 443218002976 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 443218002977 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218002978 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 443218002979 Copper resistance protein D; Region: CopD; cl00563 443218002980 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 443218002981 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443218002982 dimer interface [polypeptide binding]; other site 443218002983 ssDNA binding site [nucleotide binding]; other site 443218002984 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443218002985 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443218002986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218002987 Walker A/P-loop; other site 443218002988 ATP binding site [chemical binding]; other site 443218002989 Q-loop/lid; other site 443218002990 ABC transporter signature motif; other site 443218002991 Walker B; other site 443218002992 D-loop; other site 443218002993 H-loop/switch region; other site 443218002994 ABC transporter; Region: ABC_tran_2; pfam12848 443218002995 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218002996 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218002997 active site 443218002998 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218002999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443218003000 active site 443218003001 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443218003002 apolar tunnel; other site 443218003003 heme binding site [chemical binding]; other site 443218003004 dimerization interface [polypeptide binding]; other site 443218003005 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443218003006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218003008 active site 443218003009 Repair protein; Region: Repair_PSII; cl01535 443218003010 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443218003011 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443218003012 Zn binding site [ion binding]; other site 443218003013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218003014 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 443218003015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218003016 Helix-turn-helix domains; Region: HTH; cl00088 443218003017 Sodium:solute symporter family; Region: SSF; cl00456 443218003018 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218003019 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 443218003020 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443218003021 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443218003022 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 443218003023 urea carboxylase; Region: urea_carbox; TIGR02712 443218003024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218003025 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218003026 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218003027 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 443218003028 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 443218003029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218003030 carboxyltransferase (CT) interaction site; other site 443218003031 biotinylation site [posttranslational modification]; other site 443218003032 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 443218003033 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218003034 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218003035 active site 443218003036 catalytic triad [active] 443218003037 oxyanion hole [active] 443218003038 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443218003039 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443218003040 catalytic residues [active] 443218003041 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 443218003042 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443218003043 putative DNA binding site [nucleotide binding]; other site 443218003044 putative catalytic residues [active] 443218003045 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218003046 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218003047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218003048 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218003049 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 443218003050 trigger factor; Provisional; Region: tig; PRK01490 443218003051 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 443218003052 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443218003053 Clp protease; Region: CLP_protease; pfam00574 443218003054 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443218003055 oligomer interface [polypeptide binding]; other site 443218003056 active site residues [active] 443218003057 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443218003058 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443218003059 oligomer interface [polypeptide binding]; other site 443218003060 active site residues [active] 443218003061 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443218003062 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 443218003063 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218003064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218003065 Walker A motif; other site 443218003066 ATP binding site [chemical binding]; other site 443218003067 Walker B motif; other site 443218003068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 443218003069 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443218003070 trimer interface [polypeptide binding]; other site 443218003071 active site 443218003072 dimer interface [polypeptide binding]; other site 443218003073 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 443218003074 GTP binding site; other site 443218003075 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 443218003076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003077 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443218003078 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443218003079 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 443218003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003081 dimer interface [polypeptide binding]; other site 443218003082 conserved gate region; other site 443218003083 putative PBP binding loops; other site 443218003084 ABC-ATPase subunit interface; other site 443218003085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 443218003086 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443218003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003088 dimer interface [polypeptide binding]; other site 443218003089 conserved gate region; other site 443218003090 putative PBP binding loops; other site 443218003091 ABC-ATPase subunit interface; other site 443218003092 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443218003093 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 443218003094 Walker A/P-loop; other site 443218003095 ATP binding site [chemical binding]; other site 443218003096 Q-loop/lid; other site 443218003097 ABC transporter signature motif; other site 443218003098 Walker B; other site 443218003099 D-loop; other site 443218003100 H-loop/switch region; other site 443218003101 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 443218003102 Walker A/P-loop; other site 443218003103 ATP binding site [chemical binding]; other site 443218003104 Q-loop/lid; other site 443218003105 ABC transporter signature motif; other site 443218003106 Walker B; other site 443218003107 D-loop; other site 443218003108 H-loop/switch region; other site 443218003109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443218003110 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003111 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218003112 siderophore binding site; other site 443218003113 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218003114 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218003115 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218003116 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003117 Secretory lipase; Region: LIP; pfam03583 443218003118 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 443218003119 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 443218003120 Domain of unknown function DUF87; Region: DUF87; pfam01935 443218003121 HerA helicase [Replication, recombination, and repair]; Region: COG0433 443218003122 Pirin-related protein [General function prediction only]; Region: COG1741 443218003123 Cupin domain; Region: Cupin_2; cl09118 443218003124 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443218003125 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 443218003126 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443218003127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 443218003128 dimer interface [polypeptide binding]; other site 443218003129 active site 443218003130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218003131 catalytic residues [active] 443218003132 substrate binding site [chemical binding]; other site 443218003133 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443218003134 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 443218003135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218003136 catalytic residue [active] 443218003137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218003138 active site residue [active] 443218003139 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218003140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218003141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218003142 catalytic residue [active] 443218003143 hypothetical protein; Provisional; Region: PRK07206 443218003144 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218003145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218003146 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218003147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003149 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003150 Protein kinase domain; Region: Pkinase; pfam00069 443218003151 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003152 active site 443218003153 ATP binding site [chemical binding]; other site 443218003154 substrate binding site [chemical binding]; other site 443218003155 activation loop (A-loop); other site 443218003156 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443218003157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218003158 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 443218003159 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443218003160 HIGH motif; other site 443218003161 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443218003162 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 443218003163 active site 443218003164 KMSKS motif; other site 443218003165 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443218003166 tRNA binding surface [nucleotide binding]; other site 443218003167 anticodon binding site; other site 443218003168 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 443218003169 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443218003170 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003171 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003172 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443218003173 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443218003174 multimer interface [polypeptide binding]; other site 443218003175 active site 443218003176 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443218003177 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443218003178 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443218003179 homodimer interface [polypeptide binding]; other site 443218003180 oligonucleotide binding site [chemical binding]; other site 443218003181 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 443218003182 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 443218003183 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443218003184 GTP1/OBG; Region: GTP1_OBG; pfam01018 443218003185 Obg GTPase; Region: Obg; cd01898 443218003186 G1 box; other site 443218003187 GTP/Mg2+ binding site [chemical binding]; other site 443218003188 Switch I region; other site 443218003189 G2 box; other site 443218003190 G3 box; other site 443218003191 Switch II region; other site 443218003192 G4 box; other site 443218003193 G5 box; other site 443218003194 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 443218003195 gamma-glutamyl kinase; Provisional; Region: PRK05429 443218003196 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 443218003197 nucleotide binding site [chemical binding]; other site 443218003198 homotetrameric interface [polypeptide binding]; other site 443218003199 putative phosphate binding site [ion binding]; other site 443218003200 putative allosteric binding site; other site 443218003201 PUA domain; Region: PUA; cl00607 443218003202 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443218003203 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443218003204 active site 443218003205 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 443218003206 Membrane transport protein; Region: Mem_trans; cl09117 443218003207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218003208 dimerization interface [polypeptide binding]; other site 443218003209 putative DNA binding site [nucleotide binding]; other site 443218003210 putative Zn2+ binding site [ion binding]; other site 443218003211 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 443218003212 NAD-dependent deacetylase; Provisional; Region: PRK00481 443218003213 Cupin domain; Region: Cupin_2; cl09118 443218003214 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 443218003215 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218003216 inhibitor-cofactor binding pocket; inhibition site 443218003217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003218 catalytic residue [active] 443218003219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443218003220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218003221 Coenzyme A binding pocket [chemical binding]; other site 443218003222 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218003223 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 443218003224 substrate binding site [chemical binding]; other site 443218003225 dimer interface [polypeptide binding]; other site 443218003226 ATP binding site [chemical binding]; other site 443218003227 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443218003228 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443218003229 putative catalytic cysteine [active] 443218003230 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443218003231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218003232 Walker A motif; other site 443218003233 ATP binding site [chemical binding]; other site 443218003234 Walker B motif; other site 443218003235 arginine finger; other site 443218003236 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443218003237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218003238 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443218003239 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443218003240 active site 443218003241 (T/H)XGH motif; other site 443218003242 Oligomerisation domain; Region: Oligomerisation; cl00519 443218003243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218003244 catalytic core [active] 443218003245 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443218003246 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 443218003247 SLBB domain; Region: SLBB; pfam10531 443218003248 comEA protein; Region: comE; TIGR01259 443218003249 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218003250 Competence protein; Region: Competence; cl00471 443218003251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218003252 hypothetical protein; Reviewed; Region: PRK07914 443218003253 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 443218003254 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 443218003255 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 443218003256 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443218003257 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 443218003258 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218003259 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 443218003260 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443218003261 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 443218003262 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 443218003263 amidase catalytic site [active] 443218003264 Zn binding residues [ion binding]; other site 443218003265 substrate binding site [chemical binding]; other site 443218003266 GTP-binding protein LepA; Provisional; Region: PRK05433 443218003267 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443218003268 G1 box; other site 443218003269 putative GEF interaction site [polypeptide binding]; other site 443218003270 GTP/Mg2+ binding site [chemical binding]; other site 443218003271 Switch I region; other site 443218003272 G2 box; other site 443218003273 G3 box; other site 443218003274 Switch II region; other site 443218003275 G4 box; other site 443218003276 G5 box; other site 443218003277 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443218003278 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443218003279 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443218003280 Helix-turn-helix domains; Region: HTH; cl00088 443218003281 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 443218003282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218003283 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 443218003284 NAD(P) binding site [chemical binding]; other site 443218003285 catalytic residues [active] 443218003286 choline dehydrogenase; Validated; Region: PRK02106 443218003287 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218003288 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218003289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003290 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218003291 iron-sulfur cluster [ion binding]; other site 443218003292 [2Fe-2S] cluster binding site [ion binding]; other site 443218003293 classical (c) SDRs; Region: SDR_c; cd05233 443218003294 short chain dehydrogenase; Provisional; Region: PRK05650 443218003295 NAD(P) binding site [chemical binding]; other site 443218003296 active site 443218003297 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003298 mce related protein; Region: MCE; pfam02470 443218003299 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003300 mce related protein; Region: MCE; pfam02470 443218003301 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003302 mce related protein; Region: MCE; pfam02470 443218003303 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003304 mce related protein; Region: MCE; pfam02470 443218003305 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218003306 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 443218003307 mce related protein; Region: MCE; pfam02470 443218003308 mce related protein; Region: MCE; pfam02470 443218003309 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 443218003310 Permease; Region: Permease; cl00510 443218003311 Permease; Region: Permease; cl00510 443218003312 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218003313 hydrophobic ligand binding site; other site 443218003314 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218003315 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003316 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218003317 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218003318 AMP-binding enzyme; Region: AMP-binding; cl15778 443218003319 Nitronate monooxygenase; Region: NMO; pfam03060 443218003320 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218003321 FMN binding site [chemical binding]; other site 443218003322 substrate binding site [chemical binding]; other site 443218003323 putative catalytic residue [active] 443218003324 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 443218003325 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218003326 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218003327 intersubunit interface [polypeptide binding]; other site 443218003328 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218003329 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218003330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218003331 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443218003332 sulfate transport protein; Provisional; Region: cysT; CHL00187 443218003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003334 dimer interface [polypeptide binding]; other site 443218003335 conserved gate region; other site 443218003336 putative PBP binding loops; other site 443218003337 ABC-ATPase subunit interface; other site 443218003338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003339 dimer interface [polypeptide binding]; other site 443218003340 conserved gate region; other site 443218003341 putative PBP binding loops; other site 443218003342 ABC-ATPase subunit interface; other site 443218003343 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 443218003344 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 443218003345 Walker A/P-loop; other site 443218003346 ATP binding site [chemical binding]; other site 443218003347 Q-loop/lid; other site 443218003348 ABC transporter signature motif; other site 443218003349 Walker B; other site 443218003350 D-loop; other site 443218003351 H-loop/switch region; other site 443218003352 TOBE-like domain; Region: TOBE_3; pfam12857 443218003353 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 443218003354 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 443218003355 CysD dimerization site [polypeptide binding]; other site 443218003356 G1 box; other site 443218003357 putative GEF interaction site [polypeptide binding]; other site 443218003358 GTP/Mg2+ binding site [chemical binding]; other site 443218003359 Switch I region; other site 443218003360 G2 box; other site 443218003361 G3 box; other site 443218003362 Switch II region; other site 443218003363 G4 box; other site 443218003364 G5 box; other site 443218003365 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 443218003366 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 443218003367 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 443218003368 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218003369 Active Sites [active] 443218003370 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218003371 Active Sites [active] 443218003372 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 443218003373 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218003374 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218003375 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443218003376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218003377 FeS/SAM binding site; other site 443218003378 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443218003379 Helix-turn-helix domains; Region: HTH; cl00088 443218003380 HrcA protein C terminal domain; Region: HrcA; pfam01628 443218003381 chaperone protein DnaJ; Provisional; Region: PRK14278 443218003382 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443218003383 HSP70 interaction site [polypeptide binding]; other site 443218003384 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443218003385 Zn binding sites [ion binding]; other site 443218003386 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443218003387 dimer interface [polypeptide binding]; other site 443218003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 443218003389 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 443218003390 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 443218003391 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443218003392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218003393 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 443218003394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218003395 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218003396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218003397 Transporter associated domain; Region: CorC_HlyC; cl08393 443218003398 GTPase Era; Reviewed; Region: era; PRK00089 443218003399 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443218003400 G1 box; other site 443218003401 GTP/Mg2+ binding site [chemical binding]; other site 443218003402 Switch I region; other site 443218003403 G2 box; other site 443218003404 Switch II region; other site 443218003405 G3 box; other site 443218003406 G4 box; other site 443218003407 G5 box; other site 443218003408 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 443218003409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218003410 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 443218003411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003412 dimer interface [polypeptide binding]; other site 443218003413 conserved gate region; other site 443218003414 putative PBP binding loops; other site 443218003415 ABC-ATPase subunit interface; other site 443218003416 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 443218003417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218003418 dimer interface [polypeptide binding]; other site 443218003419 conserved gate region; other site 443218003420 putative PBP binding loops; other site 443218003421 ABC-ATPase subunit interface; other site 443218003422 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 443218003423 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 443218003424 Walker A/P-loop; other site 443218003425 ATP binding site [chemical binding]; other site 443218003426 Q-loop/lid; other site 443218003427 ABC transporter signature motif; other site 443218003428 Walker B; other site 443218003429 D-loop; other site 443218003430 H-loop/switch region; other site 443218003431 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 443218003432 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 443218003433 Walker A/P-loop; other site 443218003434 ATP binding site [chemical binding]; other site 443218003435 Q-loop/lid; other site 443218003436 ABC transporter signature motif; other site 443218003437 Walker B; other site 443218003438 D-loop; other site 443218003439 H-loop/switch region; other site 443218003440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218003441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218003442 active site 443218003443 phosphorylation site [posttranslational modification] 443218003444 intermolecular recognition site; other site 443218003445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218003446 DNA binding site [nucleotide binding] 443218003447 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443218003448 Recombination protein O N terminal; Region: RecO_N; cl15812 443218003449 Recombination protein O C terminal; Region: RecO_C; pfam02565 443218003450 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443218003451 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443218003452 catalytic residue [active] 443218003453 putative FPP diphosphate binding site; other site 443218003454 putative FPP binding hydrophobic cleft; other site 443218003455 dimer interface [polypeptide binding]; other site 443218003456 putative IPP diphosphate binding site; other site 443218003457 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218003458 metal binding site 2 [ion binding]; metal-binding site 443218003459 putative DNA binding helix; other site 443218003460 metal binding site 1 [ion binding]; metal-binding site 443218003461 dimer interface [polypeptide binding]; other site 443218003462 structural Zn2+ binding site [ion binding]; other site 443218003463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218003464 dimerization interface [polypeptide binding]; other site 443218003465 putative DNA binding site [nucleotide binding]; other site 443218003466 putative Zn2+ binding site [ion binding]; other site 443218003467 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443218003468 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 443218003469 motif 1; other site 443218003470 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 443218003471 active site 443218003472 motif 2; other site 443218003473 motif 3; other site 443218003474 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443218003475 anticodon binding site; other site 443218003476 Repair protein; Region: Repair_PSII; cl01535 443218003477 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443218003478 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218003479 putative active site [active] 443218003480 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443218003481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 443218003482 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443218003483 DNA primase; Validated; Region: dnaG; PRK05667 443218003484 CHC2 zinc finger; Region: zf-CHC2; cl15369 443218003485 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443218003486 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443218003487 active site 443218003488 metal binding site [ion binding]; metal-binding site 443218003489 interdomain interaction site; other site 443218003490 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443218003491 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 443218003492 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218003493 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218003494 active site 443218003495 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218003496 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443218003497 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218003498 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218003499 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218003500 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 443218003501 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443218003502 dimer interface [polypeptide binding]; other site 443218003503 active site 443218003504 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218003505 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218003506 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218003507 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218003508 Helix-turn-helix domains; Region: HTH; cl00088 443218003509 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443218003510 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443218003511 dimer interface [polypeptide binding]; other site 443218003512 TPP-binding site [chemical binding]; other site 443218003513 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 443218003514 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443218003515 dimer interface [polypeptide binding]; other site 443218003516 catalytic triad [active] 443218003517 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218003518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003519 active site 443218003520 ATP binding site [chemical binding]; other site 443218003521 substrate binding site [chemical binding]; other site 443218003522 activation loop (A-loop); other site 443218003523 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218003524 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443218003525 IncA protein; Region: IncA; pfam04156 443218003526 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218003527 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 443218003528 Walker A/P-loop; other site 443218003529 ATP binding site [chemical binding]; other site 443218003530 Q-loop/lid; other site 443218003531 ABC transporter signature motif; other site 443218003532 Walker B; other site 443218003533 D-loop; other site 443218003534 H-loop/switch region; other site 443218003535 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443218003536 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443218003537 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443218003538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218003539 active site 443218003540 motif I; other site 443218003541 motif II; other site 443218003542 hypothetical protein; Provisional; Region: PRK07908 443218003543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218003544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003545 homodimer interface [polypeptide binding]; other site 443218003546 catalytic residue [active] 443218003547 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443218003548 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443218003549 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 443218003550 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443218003551 Putative zinc ribbon domain; Region: DUF164; pfam02591 443218003552 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 443218003553 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 443218003554 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218003555 active site 443218003556 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218003557 catalytic core [active] 443218003558 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218003559 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 443218003560 amidase catalytic site [active] 443218003561 Zn binding residues [ion binding]; other site 443218003562 substrate binding site [chemical binding]; other site 443218003563 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443218003564 putative active site; other site 443218003565 putative metal binding residues [ion binding]; other site 443218003566 signature motif; other site 443218003567 putative triphosphate binding site [ion binding]; other site 443218003568 CHAD domain; Region: CHAD; cl10506 443218003569 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443218003570 oligomerization interface [polypeptide binding]; other site 443218003571 active site 443218003572 metal binding site [ion binding]; metal-binding site 443218003573 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218003574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218003575 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443218003576 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443218003577 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443218003578 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 443218003579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218003580 metal binding triad; other site 443218003581 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218003582 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218003583 metal binding triad; other site 443218003584 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218003585 glutamine synthetase, type I; Region: GlnA; TIGR00653 443218003586 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443218003587 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443218003588 RDD family; Region: RDD; cl00746 443218003589 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443218003590 lipoyl synthase; Provisional; Region: PRK05481 443218003591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218003592 FeS/SAM binding site; other site 443218003593 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443218003594 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 443218003595 TIGR01777 family protein; Region: yfcH 443218003596 putative NAD(P) binding site [chemical binding]; other site 443218003597 putative active site [active] 443218003598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218003599 E3 interaction surface; other site 443218003600 lipoyl attachment site [posttranslational modification]; other site 443218003601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218003602 E3 interaction surface; other site 443218003603 lipoyl attachment site [posttranslational modification]; other site 443218003604 e3 binding domain; Region: E3_binding; pfam02817 443218003605 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443218003606 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 443218003607 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443218003608 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443218003609 interface (dimer of trimers) [polypeptide binding]; other site 443218003610 Substrate-binding/catalytic site; other site 443218003611 Zn-binding sites [ion binding]; other site 443218003612 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443218003613 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443218003614 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443218003615 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443218003616 homodimer interface [polypeptide binding]; other site 443218003617 substrate-cofactor binding pocket; other site 443218003618 catalytic residue [active] 443218003619 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 443218003620 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 443218003621 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 443218003622 putative dimer interface [polypeptide binding]; other site 443218003623 active site pocket [active] 443218003624 putative cataytic base [active] 443218003625 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 443218003626 homotrimer interface [polypeptide binding]; other site 443218003627 Walker A motif; other site 443218003628 GTP binding site [chemical binding]; other site 443218003629 Walker B motif; other site 443218003630 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443218003631 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 443218003632 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 443218003633 substrate binding site [chemical binding]; other site 443218003634 ATP binding site [chemical binding]; other site 443218003635 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 443218003636 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 443218003637 active site 443218003638 dimer interface [polypeptide binding]; other site 443218003639 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 443218003640 Ligand Binding Site [chemical binding]; other site 443218003641 Molecular Tunnel; other site 443218003642 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 443218003643 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218003644 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443218003645 Predicted permeases [General function prediction only]; Region: COG0701 443218003646 Predicted permease; Region: DUF318; pfam03773 443218003647 Predicted permease; Region: DUF318; pfam03773 443218003648 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 443218003649 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443218003650 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 443218003651 Qi binding site; other site 443218003652 intrachain domain interface; other site 443218003653 interchain domain interface [polypeptide binding]; other site 443218003654 heme bH binding site [chemical binding]; other site 443218003655 heme bL binding site [chemical binding]; other site 443218003656 Qo binding site; other site 443218003657 MatE; Region: MatE; cl10513 443218003658 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443218003659 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218003660 iron-sulfur cluster [ion binding]; other site 443218003661 [2Fe-2S] cluster binding site [ion binding]; other site 443218003662 Cytochrome c; Region: Cytochrom_C; cl11414 443218003663 Cytochrome c; Region: Cytochrom_C; cl11414 443218003664 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443218003665 Subunit I/III interface [polypeptide binding]; other site 443218003666 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443218003667 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443218003668 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443218003669 Helix-turn-helix domains; Region: HTH; cl00088 443218003670 hypothetical protein; Validated; Region: PRK07883 443218003671 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443218003672 active site 443218003673 catalytic site [active] 443218003674 substrate binding site [chemical binding]; other site 443218003675 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443218003676 GIY-YIG motif/motif A; other site 443218003677 active site 443218003678 catalytic site [active] 443218003679 putative DNA binding site [nucleotide binding]; other site 443218003680 metal binding site [ion binding]; metal-binding site 443218003681 NlpC/P60 family; Region: NLPC_P60; cl11438 443218003682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 443218003683 NlpC/P60 family; Region: NLPC_P60; cl11438 443218003684 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 443218003685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218003686 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218003687 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218003688 AMP-binding enzyme; Region: AMP-binding; cl15778 443218003689 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443218003690 putative hydrophobic ligand binding site [chemical binding]; other site 443218003691 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 443218003692 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443218003693 DTAP/Switch II; other site 443218003694 Switch I; other site 443218003695 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 443218003696 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218003697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218003698 putative acyl-acceptor binding pocket; other site 443218003699 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 443218003700 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218003701 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218003702 active site 443218003703 ATP binding site [chemical binding]; other site 443218003704 substrate binding site [chemical binding]; other site 443218003705 activation loop (A-loop); other site 443218003706 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003707 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 443218003708 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003709 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443218003710 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443218003711 active site lid residues [active] 443218003712 substrate binding pocket [chemical binding]; other site 443218003713 catalytic residues [active] 443218003714 substrate-Mg2+ binding site; other site 443218003715 aspartate-rich region 1; other site 443218003716 aspartate-rich region 2; other site 443218003717 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443218003718 phytoene desaturase; Region: crtI_fam; TIGR02734 443218003719 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443218003720 substrate binding pocket [chemical binding]; other site 443218003721 chain length determination region; other site 443218003722 substrate-Mg2+ binding site; other site 443218003723 catalytic residues [active] 443218003724 aspartate-rich region 1; other site 443218003725 active site lid residues [active] 443218003726 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443218003727 aspartate-rich region 2; other site 443218003728 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 443218003729 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 443218003730 FAD binding site [chemical binding]; other site 443218003731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218003732 active site 443218003733 Protein of unknown function (DUF422); Region: DUF422; cl00991 443218003734 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218003735 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218003736 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443218003737 cell division protein MraZ; Reviewed; Region: PRK00326 443218003738 MraZ protein; Region: MraZ; pfam02381 443218003739 MraZ protein; Region: MraZ; pfam02381 443218003740 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 443218003741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218003742 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443218003743 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443218003744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218003745 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218003746 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443218003747 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003748 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003749 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218003750 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 443218003751 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003752 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003753 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443218003754 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443218003755 Mg++ binding site [ion binding]; other site 443218003756 putative catalytic motif [active] 443218003757 putative substrate binding site [chemical binding]; other site 443218003758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003759 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 443218003760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003762 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443218003763 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 443218003764 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443218003765 active site 443218003766 homodimer interface [polypeptide binding]; other site 443218003767 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443218003768 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443218003769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443218003770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443218003771 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443218003772 Cell division protein FtsQ; Region: FtsQ; pfam03799 443218003773 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 443218003774 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443218003775 nucleotide binding site [chemical binding]; other site 443218003776 SulA interaction site; other site 443218003777 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 443218003778 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 443218003779 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 443218003780 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218003781 catalytic residue [active] 443218003782 Protein of unknown function (DUF552); Region: DUF552; cl00775 443218003783 YGGT family; Region: YGGT; cl00508 443218003784 DivIVA protein; Region: DivIVA; pfam05103 443218003785 Plant ATP synthase F0; Region: YMF19; cl07975 443218003786 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 443218003787 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443218003788 active site 443218003789 catalytic site [active] 443218003790 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443218003791 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443218003792 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443218003793 active site 443218003794 catalytic site [active] 443218003795 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443218003796 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443218003797 ligand binding site; other site 443218003798 oligomer interface; other site 443218003799 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443218003800 dimer interface [polypeptide binding]; other site 443218003801 N-terminal domain interface [polypeptide binding]; other site 443218003802 sulfate 1 binding site; other site 443218003803 phosphoglucomutase; Validated; Region: PRK07564 443218003804 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 443218003805 active site 443218003806 substrate binding site [chemical binding]; other site 443218003807 metal binding site [ion binding]; metal-binding site 443218003808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443218003809 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443218003810 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443218003811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218003812 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443218003813 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443218003814 active site 443218003815 homodimer interface [polypeptide binding]; other site 443218003816 catalytic site [active] 443218003817 acceptor binding site [chemical binding]; other site 443218003818 glycogen branching enzyme; Provisional; Region: PRK05402 443218003819 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 443218003820 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443218003821 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443218003822 active site 443218003823 catalytic site [active] 443218003824 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 443218003825 agmatine deiminase; Region: agmatine_aguA; TIGR03380 443218003826 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 443218003827 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218003828 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 443218003829 active site 443218003830 catalytic triad [active] 443218003831 dimer interface [polypeptide binding]; other site 443218003832 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218003833 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218003834 Erythromycin esterase; Region: Erythro_esteras; pfam05139 443218003835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003837 short chain dehydrogenase; Provisional; Region: PRK07825 443218003838 NAD(P) binding site [chemical binding]; other site 443218003839 active site 443218003840 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218003841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003842 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218003843 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218003844 Predicted membrane protein [Function unknown]; Region: COG2311 443218003845 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218003846 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218003847 Glycerate kinase family; Region: Gly_kinase; cl00841 443218003848 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218003849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218003850 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218003851 tetramerization interface [polypeptide binding]; other site 443218003852 NAD(P) binding site [chemical binding]; other site 443218003853 catalytic residues [active] 443218003854 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443218003855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218003856 inhibitor-cofactor binding pocket; inhibition site 443218003857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003858 catalytic residue [active] 443218003859 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 443218003860 Helix-turn-helix domains; Region: HTH; cl00088 443218003861 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218003862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003863 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 443218003864 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443218003865 HIGH motif; other site 443218003866 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443218003867 active site 443218003868 KMSKS motif; other site 443218003869 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443218003870 tRNA binding surface [nucleotide binding]; other site 443218003871 anticodon binding site; other site 443218003872 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 443218003873 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 443218003874 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443218003875 active site 443218003876 Predicted permeases [General function prediction only]; Region: RarD; COG2962 443218003877 Arginase family; Region: Arginase; cl00306 443218003878 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218003879 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 443218003880 putative active site [active] 443218003881 catalytic triad [active] 443218003882 putative dimer interface [polypeptide binding]; other site 443218003883 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443218003884 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 443218003885 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443218003886 generic binding surface II; other site 443218003887 generic binding surface I; other site 443218003888 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 443218003889 reactive center loop; other site 443218003890 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218003891 threonine dehydratase; Validated; Region: PRK08639 443218003892 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443218003893 tetramer interface [polypeptide binding]; other site 443218003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003895 catalytic residue [active] 443218003896 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218003897 Helix-turn-helix domains; Region: HTH; cl00088 443218003898 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443218003899 active site 443218003900 catalytic site [active] 443218003901 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 443218003902 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443218003903 OpgC protein; Region: OpgC_C; cl00792 443218003904 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443218003905 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443218003906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218003907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218003908 DNA binding residues [nucleotide binding] 443218003909 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218003910 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 443218003911 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218003912 inhibitor-cofactor binding pocket; inhibition site 443218003913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218003914 catalytic residue [active] 443218003915 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 443218003916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218003917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218003918 catalytic residue [active] 443218003919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218003920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218003921 biotin synthase; Validated; Region: PRK06256 443218003922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218003923 FeS/SAM binding site; other site 443218003924 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 443218003925 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443218003926 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443218003927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218003928 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218003929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218003930 DNA binding residues [nucleotide binding] 443218003931 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218003932 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 443218003933 putative methyltransferase; Provisional; Region: PRK14968 443218003934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218003935 S-adenosylmethionine binding site [chemical binding]; other site 443218003936 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 443218003937 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218003938 anti sigma factor interaction site; other site 443218003939 regulatory phosphorylation site [posttranslational modification]; other site 443218003940 GAF domain; Region: GAF_2; pfam13185 443218003941 GAF domain; Region: GAF; cl15785 443218003942 ANTAR domain; Region: ANTAR; cl04297 443218003943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443218003944 active site 443218003945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003946 FAD dependent oxidoreductase; Region: DAO; pfam01266 443218003947 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218003948 iron-sulfur cluster [ion binding]; other site 443218003949 [2Fe-2S] cluster binding site [ion binding]; other site 443218003950 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443218003951 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 443218003952 putative ADP-binding pocket [chemical binding]; other site 443218003953 CsbD-like; Region: CsbD; cl15799 443218003954 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218003955 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218003956 FAD binding domain; Region: FAD_binding_4; pfam01565 443218003957 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 443218003958 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 443218003959 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 443218003960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218003961 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443218003962 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443218003963 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218003964 anti sigma factor interaction site; other site 443218003965 regulatory phosphorylation site [posttranslational modification]; other site 443218003966 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218003967 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443218003968 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218003969 hydrophobic ligand binding site; other site 443218003970 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218003971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003972 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 443218003973 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218003974 NAD binding site [chemical binding]; other site 443218003975 catalytic Zn binding site [ion binding]; other site 443218003976 structural Zn binding site [ion binding]; other site 443218003977 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443218003978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218003979 motif II; other site 443218003980 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 443218003981 putative hydrophobic ligand binding site [chemical binding]; other site 443218003982 hydroperoxidase II; Provisional; Region: katE; PRK11249 443218003983 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 443218003984 heme binding pocket [chemical binding]; other site 443218003985 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 443218003986 domain interactions; other site 443218003987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218003988 short chain dehydrogenase; Provisional; Region: PRK06701 443218003989 NAD(P) binding site [chemical binding]; other site 443218003990 active site 443218003991 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 443218003992 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218003993 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218003994 DNA binding site [nucleotide binding] 443218003995 domain linker motif; other site 443218003996 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218003997 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443218003998 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443218003999 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443218004000 Fibronectin type III-like domain; Region: Fn3-like; cl15273 443218004001 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218004002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218004003 active site 443218004004 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218004005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004007 putative substrate translocation pore; other site 443218004008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218004009 Helix-turn-helix domains; Region: HTH; cl00088 443218004010 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 443218004011 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 443218004012 Quinolinate synthetase A protein; Region: NadA; cl00420 443218004013 L-aspartate oxidase; Provisional; Region: PRK07804 443218004014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004015 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218004016 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 443218004017 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 443218004018 dimerization interface [polypeptide binding]; other site 443218004019 active site 443218004020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218004021 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443218004022 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443218004023 active site 443218004024 catalytic residues [active] 443218004025 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 443218004026 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 443218004027 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443218004028 NAD binding site [chemical binding]; other site 443218004029 dimerization interface [polypeptide binding]; other site 443218004030 product binding site; other site 443218004031 substrate binding site [chemical binding]; other site 443218004032 zinc binding site [ion binding]; other site 443218004033 catalytic residues [active] 443218004034 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443218004035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218004036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004037 homodimer interface [polypeptide binding]; other site 443218004038 catalytic residue [active] 443218004039 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 443218004040 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443218004041 putative active site pocket [active] 443218004042 4-fold oligomerization interface [polypeptide binding]; other site 443218004043 metal binding residues [ion binding]; metal-binding site 443218004044 3-fold/trimer interface [polypeptide binding]; other site 443218004045 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443218004046 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443218004047 putative active site [active] 443218004048 oxyanion strand; other site 443218004049 catalytic triad [active] 443218004050 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 443218004051 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443218004052 catalytic residues [active] 443218004053 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 443218004054 active site 443218004055 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443218004056 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443218004057 substrate binding site [chemical binding]; other site 443218004058 glutamase interaction surface [polypeptide binding]; other site 443218004059 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 443218004060 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 443218004061 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443218004062 active site 1 [active] 443218004063 dimer interface [polypeptide binding]; other site 443218004064 hexamer interface [polypeptide binding]; other site 443218004065 active site 2 [active] 443218004066 GYD domain; Region: GYD; cl01743 443218004067 Protein of unknown function (DUF998); Region: DUF998; pfam06197 443218004068 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218004069 anthranilate synthase component I; Provisional; Region: PRK13571 443218004070 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443218004071 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218004072 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 443218004073 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443218004074 active site 443218004075 ribulose/triose binding site [chemical binding]; other site 443218004076 phosphate binding site [ion binding]; other site 443218004077 substrate (anthranilate) binding pocket [chemical binding]; other site 443218004078 product (indole) binding pocket [chemical binding]; other site 443218004079 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443218004080 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 443218004081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004082 catalytic residue [active] 443218004083 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 443218004084 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443218004085 substrate binding site [chemical binding]; other site 443218004086 active site 443218004087 catalytic residues [active] 443218004088 heterodimer interface [polypeptide binding]; other site 443218004089 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 443218004090 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 443218004091 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443218004092 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443218004093 active site 443218004094 dimer interface [polypeptide binding]; other site 443218004095 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443218004096 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218004097 active site 443218004098 FMN binding site [chemical binding]; other site 443218004099 substrate binding site [chemical binding]; other site 443218004100 3Fe-4S cluster binding site [ion binding]; other site 443218004101 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443218004102 domain interface; other site 443218004103 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443218004104 pyruvate kinase; Provisional; Region: PRK06247 443218004105 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218004106 active site 443218004107 domain interfaces; other site 443218004108 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 443218004109 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218004110 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443218004111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218004112 active site 443218004113 phosphorylation site [posttranslational modification] 443218004114 intermolecular recognition site; other site 443218004115 dimerization interface [polypeptide binding]; other site 443218004116 ANTAR domain; Region: ANTAR; cl04297 443218004117 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443218004118 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443218004119 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443218004120 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 443218004121 Walker A/P-loop; other site 443218004122 ATP binding site [chemical binding]; other site 443218004123 Q-loop/lid; other site 443218004124 ABC transporter signature motif; other site 443218004125 Walker B; other site 443218004126 D-loop; other site 443218004127 H-loop/switch region; other site 443218004128 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443218004129 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 443218004130 Walker A/P-loop; other site 443218004131 ATP binding site [chemical binding]; other site 443218004132 Q-loop/lid; other site 443218004133 ABC transporter signature motif; other site 443218004134 Walker B; other site 443218004135 D-loop; other site 443218004136 H-loop/switch region; other site 443218004137 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218004138 TM-ABC transporter signature motif; other site 443218004139 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 443218004140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218004141 TM-ABC transporter signature motif; other site 443218004142 DNA polymerase I; Provisional; Region: PRK05755 443218004143 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443218004144 active site 443218004145 metal binding site 1 [ion binding]; metal-binding site 443218004146 putative 5' ssDNA interaction site; other site 443218004147 metal binding site 3; metal-binding site 443218004148 metal binding site 2 [ion binding]; metal-binding site 443218004149 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443218004150 putative DNA binding site [nucleotide binding]; other site 443218004151 putative metal binding site [ion binding]; other site 443218004152 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443218004153 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443218004154 active site 443218004155 DNA binding site [nucleotide binding] 443218004156 catalytic site [active] 443218004157 FAD dependent oxidoreductase; Region: DAO; pfam01266 443218004158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004159 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 443218004160 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443218004161 conserved cys residue [active] 443218004162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218004163 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443218004164 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 443218004165 tartrate dehydrogenase; Provisional; Region: PRK08194 443218004166 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218004167 catalytic residues [active] 443218004168 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218004169 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218004170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004171 S-adenosylmethionine binding site [chemical binding]; other site 443218004172 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443218004173 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443218004174 RNA binding site [nucleotide binding]; other site 443218004175 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443218004176 RNA binding site [nucleotide binding]; other site 443218004177 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218004178 RNA binding site [nucleotide binding]; other site 443218004179 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218004180 RNA binding site [nucleotide binding]; other site 443218004181 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 443218004182 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443218004183 CoA-binding site [chemical binding]; other site 443218004184 ATP-binding [chemical binding]; other site 443218004185 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 443218004186 Protein of unknown function (DUF402); Region: DUF402; cl00979 443218004187 excinuclease ABC subunit B; Provisional; Region: PRK05298 443218004188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218004190 nucleotide binding region [chemical binding]; other site 443218004191 ATP-binding site [chemical binding]; other site 443218004192 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443218004193 UvrB/uvrC motif; Region: UVR; pfam02151 443218004194 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443218004195 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 443218004196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004197 Family description; Region: UvrD_C_2; cl15862 443218004198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218004199 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443218004200 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 443218004201 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 443218004202 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 443218004203 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 443218004204 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443218004205 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443218004206 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 443218004207 ribosomal protein L20; Region: rpl20; CHL00068 443218004208 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443218004209 23S rRNA binding site [nucleotide binding]; other site 443218004210 L21 binding site [polypeptide binding]; other site 443218004211 L13 binding site [polypeptide binding]; other site 443218004212 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443218004213 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 443218004214 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 443218004215 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443218004216 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443218004217 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443218004218 dimer interface [polypeptide binding]; other site 443218004219 motif 1; other site 443218004220 active site 443218004221 motif 2; other site 443218004222 motif 3; other site 443218004223 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443218004224 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443218004225 putative tRNA-binding site [nucleotide binding]; other site 443218004226 B3/4 domain; Region: B3_4; cl11458 443218004227 tRNA synthetase B5 domain; Region: B5; cl08394 443218004228 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443218004229 dimer interface [polypeptide binding]; other site 443218004230 motif 1; other site 443218004231 motif 3; other site 443218004232 motif 2; other site 443218004233 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 443218004234 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 443218004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004236 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 443218004237 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443218004238 heterotetramer interface [polypeptide binding]; other site 443218004239 active site pocket [active] 443218004240 cleavage site 443218004241 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443218004242 feedback inhibition sensing region; other site 443218004243 homohexameric interface [polypeptide binding]; other site 443218004244 nucleotide binding site [chemical binding]; other site 443218004245 N-acetyl-L-glutamate binding site [chemical binding]; other site 443218004246 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443218004247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218004248 inhibitor-cofactor binding pocket; inhibition site 443218004249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218004250 catalytic residue [active] 443218004251 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443218004252 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443218004253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004254 arginine repressor; Provisional; Region: PRK03341 443218004255 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 443218004256 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 443218004257 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 443218004258 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443218004259 ANP binding site [chemical binding]; other site 443218004260 Substrate Binding Site II [chemical binding]; other site 443218004261 Substrate Binding Site I [chemical binding]; other site 443218004262 argininosuccinate lyase; Provisional; Region: PRK00855 443218004263 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443218004264 active sites [active] 443218004265 tetramer interface [polypeptide binding]; other site 443218004266 acyl-CoA synthetase; Validated; Region: PRK07868 443218004267 AMP-binding enzyme; Region: AMP-binding; cl15778 443218004268 Trm112p-like protein; Region: Trm112p; cl01066 443218004269 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443218004270 active site 443218004271 DNA binding site [nucleotide binding] 443218004272 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443218004273 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443218004274 active site 443218004275 HIGH motif; other site 443218004276 dimer interface [polypeptide binding]; other site 443218004277 KMSKS motif; other site 443218004278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 443218004279 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443218004280 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218004281 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218004282 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443218004283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218004284 RNA binding surface [nucleotide binding]; other site 443218004285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218004286 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 443218004287 DNA repair protein RecN; Region: recN; TIGR00634 443218004288 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 443218004289 Walker A/P-loop; other site 443218004290 ATP binding site [chemical binding]; other site 443218004291 Q-loop/lid; other site 443218004292 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 443218004293 ABC transporter signature motif; other site 443218004294 Walker B; other site 443218004295 D-loop; other site 443218004296 H-loop/switch region; other site 443218004297 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 443218004298 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 443218004299 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 443218004300 CTP synthetase; Validated; Region: pyrG; PRK05380 443218004301 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443218004302 Catalytic site [active] 443218004303 active site 443218004304 UTP binding site [chemical binding]; other site 443218004305 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443218004306 active site 443218004307 putative oxyanion hole; other site 443218004308 catalytic triad [active] 443218004309 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443218004310 dimer interface [polypeptide binding]; other site 443218004311 ADP-ribose binding site [chemical binding]; other site 443218004312 active site 443218004313 nudix motif; other site 443218004314 metal binding site [ion binding]; metal-binding site 443218004315 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443218004316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218004317 active site 443218004318 DNA binding site [nucleotide binding] 443218004319 Int/Topo IB signature motif; other site 443218004320 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218004321 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218004322 P-loop; other site 443218004323 Magnesium ion binding site [ion binding]; other site 443218004324 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218004325 Magnesium ion binding site [ion binding]; other site 443218004326 ScpA/B protein; Region: ScpA_ScpB; cl00598 443218004327 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 443218004328 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443218004329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218004330 RNA binding surface [nucleotide binding]; other site 443218004331 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443218004332 active site 443218004333 cytidylate kinase; Provisional; Region: cmk; PRK00023 443218004334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004335 active site 443218004336 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443218004337 CMP-binding site; other site 443218004338 The sites determining sugar specificity; other site 443218004339 GTP-binding protein Der; Reviewed; Region: PRK03003 443218004340 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443218004341 G1 box; other site 443218004342 GTP/Mg2+ binding site [chemical binding]; other site 443218004343 Switch I region; other site 443218004344 G2 box; other site 443218004345 Switch II region; other site 443218004346 G3 box; other site 443218004347 G4 box; other site 443218004348 G5 box; other site 443218004349 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443218004350 G1 box; other site 443218004351 GTP/Mg2+ binding site [chemical binding]; other site 443218004352 Switch I region; other site 443218004353 G2 box; other site 443218004354 G3 box; other site 443218004355 Switch II region; other site 443218004356 G4 box; other site 443218004357 G5 box; other site 443218004358 Protein of unknown function (DUF421); Region: DUF421; cl00990 443218004359 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218004360 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 443218004361 Protein of unknown function (DUF419); Region: DUF419; cl15265 443218004362 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218004363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 443218004364 Helix-turn-helix domains; Region: HTH; cl00088 443218004365 PAS fold; Region: PAS_3; pfam08447 443218004366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218004367 putative active site [active] 443218004368 heme pocket [chemical binding]; other site 443218004369 ANTAR domain; Region: ANTAR; cl04297 443218004370 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 443218004371 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443218004372 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 443218004373 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218004374 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218004375 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 443218004376 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218004377 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218004378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218004379 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 443218004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004381 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443218004382 putative substrate translocation pore; other site 443218004383 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 443218004384 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 443218004385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004386 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 443218004387 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 443218004388 Nitrogen regulatory protein P-II; Region: P-II; cl00412 443218004389 Nitrogen regulatory protein P-II; Region: P-II; smart00938 443218004390 PII uridylyl-transferase; Provisional; Region: PRK03381 443218004391 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443218004392 metal binding triad; other site 443218004393 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443218004394 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 443218004395 signal recognition particle protein; Provisional; Region: PRK10867 443218004396 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 443218004397 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443218004398 P loop; other site 443218004399 GTP binding site [chemical binding]; other site 443218004400 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443218004401 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443218004402 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218004403 active site 443218004404 CAAX protease self-immunity; Region: Abi; cl00558 443218004405 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 443218004406 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 443218004407 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443218004408 RimM N-terminal domain; Region: RimM; pfam01782 443218004409 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 443218004410 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 443218004411 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 443218004412 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 443218004413 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 443218004414 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218004415 RNA binding site [nucleotide binding]; other site 443218004416 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 443218004417 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443218004418 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443218004419 Catalytic site [active] 443218004420 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443218004421 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443218004422 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218004423 active site 443218004424 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443218004425 Restriction endonuclease; Region: Mrr_cat; cl00516 443218004426 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443218004427 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 443218004428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004429 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443218004430 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443218004431 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 443218004432 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443218004433 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218004434 active site 443218004435 DNA binding site [nucleotide binding] 443218004436 Int/Topo IB signature motif; other site 443218004437 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218004438 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443218004439 rRNA interaction site [nucleotide binding]; other site 443218004440 S8 interaction site; other site 443218004441 elongation factor Ts; Provisional; Region: tsf; PRK09377 443218004442 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 443218004443 Elongation factor TS; Region: EF_TS; pfam00889 443218004444 Elongation factor TS; Region: EF_TS; pfam00889 443218004445 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443218004446 putative nucleotide binding site [chemical binding]; other site 443218004447 uridine monophosphate binding site [chemical binding]; other site 443218004448 homohexameric interface [polypeptide binding]; other site 443218004449 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443218004450 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 443218004451 hinge region; other site 443218004452 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 443218004453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218004454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004455 S-adenosylmethionine binding site [chemical binding]; other site 443218004456 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 443218004457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218004458 FeS/SAM binding site; other site 443218004459 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 443218004460 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443218004461 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443218004462 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443218004463 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443218004464 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443218004465 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443218004466 active site 443218004467 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 443218004468 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 443218004469 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443218004470 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443218004471 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443218004472 Predicted acetyltransferase [General function prediction only]; Region: COG3393 443218004473 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 443218004474 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218004475 methionine aminopeptidase; Provisional; Region: PRK12318 443218004476 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218004477 active site 443218004478 cobyric acid synthase; Provisional; Region: PRK00784 443218004479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004480 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 443218004481 catalytic triad [active] 443218004482 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218004483 Helix-turn-helix domains; Region: HTH; cl00088 443218004484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218004485 FAD binding domain; Region: FAD_binding_4; pfam01565 443218004486 diacylglycerol kinase; Reviewed; Region: PRK11914 443218004487 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 443218004488 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218004489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218004490 Walker A/P-loop; other site 443218004491 ATP binding site [chemical binding]; other site 443218004492 Q-loop/lid; other site 443218004493 ABC transporter signature motif; other site 443218004494 Walker B; other site 443218004495 D-loop; other site 443218004496 H-loop/switch region; other site 443218004497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218004498 DNA-binding site [nucleotide binding]; DNA binding site 443218004499 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 443218004500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218004501 DNA-binding site [nucleotide binding]; DNA binding site 443218004502 FCD domain; Region: FCD; cl11656 443218004503 mycothione reductase; Reviewed; Region: PRK07846 443218004504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218004505 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218004506 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218004507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218004508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004509 Predicted dehydrogenase [General function prediction only]; Region: COG0579 443218004510 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 443218004511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218004512 Walker A motif; other site 443218004513 ATP binding site [chemical binding]; other site 443218004514 Walker B motif; other site 443218004515 arginine finger; other site 443218004516 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 443218004517 metal ion-dependent adhesion site (MIDAS); other site 443218004518 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 443218004519 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 443218004520 Walker A motif; other site 443218004521 homodimer interface [polypeptide binding]; other site 443218004522 ATP binding site [chemical binding]; other site 443218004523 hydroxycobalamin binding site [chemical binding]; other site 443218004524 Walker B motif; other site 443218004525 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 443218004526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004528 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 443218004529 catalytic triad [active] 443218004530 siroheme synthase; Provisional; Region: cysG; PRK10637 443218004531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004532 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218004533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218004534 putative substrate translocation pore; other site 443218004535 Protein of unknown function (DUF328); Region: DUF328; cl01143 443218004536 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443218004537 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 443218004538 motif 1; other site 443218004539 dimer interface [polypeptide binding]; other site 443218004540 active site 443218004541 motif 2; other site 443218004542 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 443218004543 putative deacylase active site [active] 443218004544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 443218004545 active site 443218004546 motif 3; other site 443218004547 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443218004548 anticodon binding site; other site 443218004549 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443218004550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218004551 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 443218004552 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 443218004553 dinuclear metal binding motif [ion binding]; other site 443218004554 ribosome maturation protein RimP; Reviewed; Region: PRK00092 443218004555 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 443218004556 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 443218004557 Sm1 motif; other site 443218004558 D1 - D2 interaction site; other site 443218004559 D3 - B interaction site; other site 443218004560 Hfq - Hfq interaction site; other site 443218004561 RNA binding pocket [nucleotide binding]; other site 443218004562 Sm2 motif; other site 443218004563 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443218004564 NusA N-terminal domain; Region: NusA_N; pfam08529 443218004565 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443218004566 RNA binding site [nucleotide binding]; other site 443218004567 homodimer interface [polypeptide binding]; other site 443218004568 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 443218004569 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443218004570 G-X-X-G motif; other site 443218004571 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 443218004572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218004573 translation initiation factor IF-2; Region: IF-2; TIGR00487 443218004574 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443218004575 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443218004576 G1 box; other site 443218004577 putative GEF interaction site [polypeptide binding]; other site 443218004578 GTP/Mg2+ binding site [chemical binding]; other site 443218004579 Switch I region; other site 443218004580 G2 box; other site 443218004581 G3 box; other site 443218004582 Switch II region; other site 443218004583 G4 box; other site 443218004584 G5 box; other site 443218004585 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443218004586 Translation-initiation factor 2; Region: IF-2; pfam11987 443218004587 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443218004588 Protein of unknown function (DUF503); Region: DUF503; cl00669 443218004589 Ribosome-binding factor A; Region: RBFA; cl00542 443218004590 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 443218004591 DHH family; Region: DHH; pfam01368 443218004592 MatE; Region: MatE; cl10513 443218004593 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443218004594 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443218004595 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218004596 active site 443218004597 metal binding site [ion binding]; metal-binding site 443218004598 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443218004599 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 443218004600 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443218004601 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443218004602 RNA binding site [nucleotide binding]; other site 443218004603 active site 443218004604 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443218004605 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443218004606 Helix-turn-helix domains; Region: HTH; cl00088 443218004607 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443218004608 FeoA domain; Region: FeoA; cl00838 443218004609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218004610 ABC-ATPase subunit interface; other site 443218004611 dimer interface [polypeptide binding]; other site 443218004612 putative PBP binding regions; other site 443218004613 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443218004614 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 443218004615 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 443218004616 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218004617 metal binding site [ion binding]; metal-binding site 443218004618 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443218004619 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443218004620 active site 443218004621 Riboflavin kinase; Region: Flavokinase; cl03312 443218004622 LabA_like proteins; Region: LabA_like; cd06167 443218004623 putative metal binding site [ion binding]; other site 443218004624 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443218004625 16S/18S rRNA binding site [nucleotide binding]; other site 443218004626 S13e-L30e interaction site [polypeptide binding]; other site 443218004627 25S rRNA binding site [nucleotide binding]; other site 443218004628 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443218004629 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443218004630 oligomer interface [polypeptide binding]; other site 443218004631 RNA binding site [nucleotide binding]; other site 443218004632 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443218004633 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443218004634 RNase E interface [polypeptide binding]; other site 443218004635 trimer interface [polypeptide binding]; other site 443218004636 active site 443218004637 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443218004638 putative nucleic acid binding region [nucleotide binding]; other site 443218004639 G-X-X-G motif; other site 443218004640 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443218004641 RNA binding site [nucleotide binding]; other site 443218004642 domain interface; other site 443218004643 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443218004644 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443218004645 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443218004646 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443218004647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004648 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443218004649 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218004650 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 443218004651 putative hydrophobic ligand binding site [chemical binding]; other site 443218004652 Thymidylate synthase complementing protein; Region: Thy1; cl03630 443218004653 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443218004654 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443218004655 dimer interface [polypeptide binding]; other site 443218004656 active site 443218004657 catalytic residue [active] 443218004658 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443218004659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218004660 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443218004661 Putative sensor; Region: Sensor; pfam13796 443218004662 Histidine kinase; Region: HisKA_3; pfam07730 443218004663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218004664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218004665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218004666 active site 443218004667 phosphorylation site [posttranslational modification] 443218004668 intermolecular recognition site; other site 443218004669 dimerization interface [polypeptide binding]; other site 443218004670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218004671 DNA binding residues [nucleotide binding] 443218004672 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218004673 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 443218004674 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 443218004675 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443218004676 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443218004677 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443218004678 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218004679 rod shape-determining protein MreB; Provisional; Region: PRK13930 443218004680 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 443218004681 ATP binding site [chemical binding]; other site 443218004682 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443218004683 NlpC/P60 family; Region: NLPC_P60; cl11438 443218004684 Cupin domain; Region: Cupin_2; cl09118 443218004685 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218004686 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218004687 putative active site [active] 443218004688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218004689 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 443218004690 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 443218004691 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 443218004692 Proline dehydrogenase; Region: Pro_dh; cl03282 443218004693 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218004694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218004695 NAD(P) binding site [chemical binding]; other site 443218004696 catalytic residues [active] 443218004697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218004698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 443218004699 putative dimerization interface [polypeptide binding]; other site 443218004700 Sodium:solute symporter family; Region: SSF; cl00456 443218004701 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218004702 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218004703 catalytic residue [active] 443218004704 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 443218004705 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 443218004706 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218004707 HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244 443218004708 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 443218004709 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 443218004710 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 443218004711 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218004712 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443218004713 active site 443218004714 catalytic site [active] 443218004715 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443218004716 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218004717 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218004718 Walker A/P-loop; other site 443218004719 ATP binding site [chemical binding]; other site 443218004720 Q-loop/lid; other site 443218004721 ABC transporter signature motif; other site 443218004722 Walker B; other site 443218004723 D-loop; other site 443218004724 H-loop/switch region; other site 443218004725 TOBE domain; Region: TOBE_2; cl01440 443218004726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218004727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218004728 dimer interface [polypeptide binding]; other site 443218004729 conserved gate region; other site 443218004730 putative PBP binding loops; other site 443218004731 ABC-ATPase subunit interface; other site 443218004732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218004733 dimer interface [polypeptide binding]; other site 443218004734 conserved gate region; other site 443218004735 putative PBP binding loops; other site 443218004736 ABC-ATPase subunit interface; other site 443218004737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218004738 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218004739 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218004740 active site 443218004741 catalytic site [active] 443218004742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218004743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218004744 DNA binding site [nucleotide binding] 443218004745 domain linker motif; other site 443218004746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218004747 dimerization interface [polypeptide binding]; other site 443218004748 ligand binding site [chemical binding]; other site 443218004749 short chain dehydrogenase; Provisional; Region: PRK07814 443218004750 classical (c) SDRs; Region: SDR_c; cd05233 443218004751 NAD(P) binding site [chemical binding]; other site 443218004752 active site 443218004753 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218004754 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218004755 active site 443218004756 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 443218004757 Phosphotransferase enzyme family; Region: APH; pfam01636 443218004758 putative active site [active] 443218004759 putative substrate binding site [chemical binding]; other site 443218004760 ATP binding site [chemical binding]; other site 443218004761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218004762 Helix-turn-helix domains; Region: HTH; cl00088 443218004763 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218004764 DNA translocase FtsK; Provisional; Region: PRK10263 443218004765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004766 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 443218004767 Integral membrane protein TerC family; Region: TerC; cl10468 443218004768 YCII-related domain; Region: YCII; cl00999 443218004769 YCII-related domain; Region: YCII; cl00999 443218004770 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218004771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218004772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218004773 YCII-related domain; Region: YCII; cl00999 443218004774 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 443218004775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218004776 Coenzyme A binding pocket [chemical binding]; other site 443218004777 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218004778 Competence-damaged protein; Region: CinA; cl00666 443218004779 PspA/IM30 family; Region: PspA_IM30; pfam04012 443218004780 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443218004781 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218004782 homodimer interface [polypeptide binding]; other site 443218004783 active site 443218004784 TDP-binding site; other site 443218004785 acceptor substrate-binding pocket; other site 443218004786 Epoxide hydrolase N terminus; Region: EHN; pfam06441 443218004787 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218004788 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 443218004789 recombinase A; Provisional; Region: recA; PRK09354 443218004790 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443218004791 hexamer interface [polypeptide binding]; other site 443218004792 Walker A motif; other site 443218004793 ATP binding site [chemical binding]; other site 443218004794 Walker B motif; other site 443218004795 RecX family; Region: RecX; cl00936 443218004796 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 443218004797 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 443218004798 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 443218004799 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 443218004800 NMT1-like family; Region: NMT1_2; cl15260 443218004801 Domain of unknown function (DUF897); Region: DUF897; cl01312 443218004802 Helix-turn-helix domains; Region: HTH; cl00088 443218004803 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443218004804 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443218004805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218004806 FeS/SAM binding site; other site 443218004807 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218004808 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218004809 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443218004810 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 443218004811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218004812 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443218004813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218004814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218004815 DNA binding site [nucleotide binding] 443218004816 domain linker motif; other site 443218004817 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 443218004818 putative dimerization interface [polypeptide binding]; other site 443218004819 putative ligand binding site [chemical binding]; other site 443218004820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218004821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218004822 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443218004823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218004824 dimer interface [polypeptide binding]; other site 443218004825 conserved gate region; other site 443218004826 putative PBP binding loops; other site 443218004827 ABC-ATPase subunit interface; other site 443218004828 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218004830 dimer interface [polypeptide binding]; other site 443218004831 conserved gate region; other site 443218004832 putative PBP binding loops; other site 443218004833 ABC-ATPase subunit interface; other site 443218004834 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443218004835 active site 443218004836 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218004837 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218004838 Walker A/P-loop; other site 443218004839 ATP binding site [chemical binding]; other site 443218004840 Q-loop/lid; other site 443218004841 ABC transporter signature motif; other site 443218004842 Walker B; other site 443218004843 D-loop; other site 443218004844 H-loop/switch region; other site 443218004845 TOBE domain; Region: TOBE_2; cl01440 443218004846 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218004847 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218004848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218004849 Transporter associated domain; Region: CorC_HlyC; cl08393 443218004850 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218004851 FOG: CBS domain [General function prediction only]; Region: COG0517 443218004852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218004853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004854 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218004855 NAD(P) binding site [chemical binding]; other site 443218004856 active site 443218004857 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 443218004858 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443218004859 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443218004860 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 443218004861 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443218004862 HflX GTPase family; Region: HflX; cd01878 443218004863 G1 box; other site 443218004864 GTP/Mg2+ binding site [chemical binding]; other site 443218004865 Switch I region; other site 443218004866 G2 box; other site 443218004867 G3 box; other site 443218004868 Switch II region; other site 443218004869 G4 box; other site 443218004870 G5 box; other site 443218004871 LexA repressor; Validated; Region: PRK00215 443218004872 Helix-turn-helix domains; Region: HTH; cl00088 443218004873 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443218004874 Catalytic site [active] 443218004875 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443218004876 ATP cone domain; Region: ATP-cone; pfam03477 443218004877 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 443218004878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218004879 ATP binding site [chemical binding]; other site 443218004880 putative Mg++ binding site [ion binding]; other site 443218004881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218004882 nucleotide binding region [chemical binding]; other site 443218004883 ATP-binding site [chemical binding]; other site 443218004884 Helicase associated domain (HA2); Region: HA2; cl04503 443218004885 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 443218004886 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 443218004887 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443218004888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443218004890 NAD(P) binding site [chemical binding]; other site 443218004891 active site 443218004892 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218004893 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 443218004894 dimer interface [polypeptide binding]; other site 443218004895 active site 443218004896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218004897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218004898 active site 443218004899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218004900 active site 443218004901 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443218004902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218004903 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443218004904 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 443218004905 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218004906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218004907 ATP binding site [chemical binding]; other site 443218004908 putative Mg++ binding site [ion binding]; other site 443218004909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218004910 nucleotide binding region [chemical binding]; other site 443218004911 ATP-binding site [chemical binding]; other site 443218004912 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 443218004913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218004914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218004915 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 443218004916 PAC2 family; Region: PAC2; cl00847 443218004917 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 443218004918 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 443218004919 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 443218004920 NAD binding site [chemical binding]; other site 443218004921 homodimer interface [polypeptide binding]; other site 443218004922 active site 443218004923 substrate binding site [chemical binding]; other site 443218004924 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443218004925 Helix-turn-helix domains; Region: HTH; cl00088 443218004926 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443218004927 FeoA domain; Region: FeoA; cl00838 443218004928 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 443218004929 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 443218004930 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218004932 Coenzyme A binding pocket [chemical binding]; other site 443218004933 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 443218004934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004935 CoA-ligase; Region: Ligase_CoA; cl02894 443218004936 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218004937 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443218004938 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443218004939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218004940 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218004941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218004942 DNA binding residues [nucleotide binding] 443218004943 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 443218004944 putative active site [active] 443218004945 dimerization interface [polypeptide binding]; other site 443218004946 putative tRNAtyr binding site [nucleotide binding]; other site 443218004947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218004948 S-adenosylmethionine binding site [chemical binding]; other site 443218004949 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443218004950 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 443218004951 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 443218004952 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443218004953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218004954 ATP binding site [chemical binding]; other site 443218004955 putative Mg++ binding site [ion binding]; other site 443218004956 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443218004957 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443218004958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218004959 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218004960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218004961 DNA binding residues [nucleotide binding] 443218004962 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218004963 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218004964 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443218004965 active site 443218004966 dimerization interface [polypeptide binding]; other site 443218004967 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218004968 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 443218004969 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 443218004970 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443218004971 trimer interface [polypeptide binding]; other site 443218004972 active site 443218004973 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443218004974 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443218004975 TRAM domain; Region: TRAM; cl01282 443218004976 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443218004977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218004978 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443218004979 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443218004980 TPP-binding site; other site 443218004981 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218004982 PYR/PP interface [polypeptide binding]; other site 443218004983 dimer interface [polypeptide binding]; other site 443218004984 TPP binding site [chemical binding]; other site 443218004985 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218004986 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443218004987 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443218004988 catalytic site [active] 443218004989 putative active site [active] 443218004990 putative substrate binding site [chemical binding]; other site 443218004991 HRDC domain; Region: HRDC; cl02578 443218004992 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443218004993 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443218004994 substrate binding site [chemical binding]; other site 443218004995 active site 443218004996 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443218004997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218004998 Chlorite dismutase; Region: Chlor_dismutase; cl01280 443218004999 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 443218005000 SelR domain; Region: SelR; pfam01641 443218005001 Domain of unknown function (DUF389); Region: DUF389; cl00781 443218005002 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218005003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218005004 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218005005 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443218005006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005007 Walker A motif; other site 443218005008 ATP binding site [chemical binding]; other site 443218005009 Walker B motif; other site 443218005010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218005011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218005012 Coenzyme A binding pocket [chemical binding]; other site 443218005013 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 443218005014 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443218005015 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 443218005016 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443218005017 active site 443218005018 dimer interface [polypeptide binding]; other site 443218005019 motif 1; other site 443218005020 motif 2; other site 443218005021 motif 3; other site 443218005022 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443218005023 anticodon binding site; other site 443218005024 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443218005025 nucleotide binding site/active site [active] 443218005026 HIT family signature motif; other site 443218005027 catalytic residue [active] 443218005028 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218005029 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 443218005030 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 443218005031 putative acyl-acceptor binding pocket; other site 443218005032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218005033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218005034 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 443218005035 nudix motif; other site 443218005036 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443218005037 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443218005038 active site 443218005039 multimer interface [polypeptide binding]; other site 443218005040 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443218005041 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443218005042 active site 443218005043 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443218005044 catalytic triad [active] 443218005045 dimer interface [polypeptide binding]; other site 443218005046 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443218005047 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 443218005048 predicted active site [active] 443218005049 catalytic triad [active] 443218005050 Transcriptional regulator; Region: Transcrip_reg; cl00361 443218005051 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 443218005052 active site 443218005053 putative DNA-binding cleft [nucleotide binding]; other site 443218005054 dimer interface [polypeptide binding]; other site 443218005055 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443218005056 RuvA N terminal domain; Region: RuvA_N; pfam01330 443218005057 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443218005058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005059 Walker A motif; other site 443218005060 ATP binding site [chemical binding]; other site 443218005061 Walker B motif; other site 443218005062 arginine finger; other site 443218005063 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443218005064 Preprotein translocase subunit; Region: YajC; cl00806 443218005065 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 443218005066 Protein export membrane protein; Region: SecD_SecF; cl14618 443218005067 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443218005068 Protein export membrane protein; Region: SecD_SecF; cl14618 443218005069 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443218005070 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443218005071 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 443218005072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218005073 active site 443218005074 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 443218005075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 443218005076 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443218005077 synthetase active site [active] 443218005078 NTP binding site [chemical binding]; other site 443218005079 metal binding site [ion binding]; metal-binding site 443218005080 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443218005081 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443218005082 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443218005083 active site 443218005084 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443218005085 active site 443218005086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218005087 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 443218005088 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 443218005089 dimer interface [polypeptide binding]; other site 443218005090 motif 1; other site 443218005091 active site 443218005092 motif 2; other site 443218005093 motif 3; other site 443218005094 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 443218005095 anticodon binding site; other site 443218005096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218005097 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443218005098 FeS/SAM binding site; other site 443218005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218005100 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218005101 putative substrate translocation pore; other site 443218005102 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443218005103 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 443218005104 putative DNA binding site [nucleotide binding]; other site 443218005105 catalytic residue [active] 443218005106 putative H2TH interface [polypeptide binding]; other site 443218005107 putative catalytic residues [active] 443218005108 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218005109 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218005110 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 443218005111 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 443218005112 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 443218005113 dimer interface [polypeptide binding]; other site 443218005114 anticodon binding site; other site 443218005115 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 443218005116 homodimer interface [polypeptide binding]; other site 443218005117 motif 1; other site 443218005118 active site 443218005119 motif 2; other site 443218005120 GAD domain; Region: GAD; pfam02938 443218005121 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 443218005122 active site 443218005123 motif 3; other site 443218005124 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 443218005125 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 443218005126 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443218005127 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 443218005128 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218005129 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218005130 Sulfatase; Region: Sulfatase; cl10460 443218005131 PhoD-like phosphatase; Region: PhoD; pfam09423 443218005132 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218005133 putative active site [active] 443218005134 putative metal binding site [ion binding]; other site 443218005135 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218005136 recombination factor protein RarA; Reviewed; Region: PRK13342 443218005137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005138 Walker A motif; other site 443218005139 ATP binding site [chemical binding]; other site 443218005140 Walker B motif; other site 443218005141 arginine finger; other site 443218005142 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443218005143 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443218005144 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 443218005145 motif 1; other site 443218005146 active site 443218005147 motif 2; other site 443218005148 motif 3; other site 443218005149 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 443218005150 DHHA1 domain; Region: DHHA1; pfam02272 443218005151 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 443218005152 YceG-like family; Region: YceG; pfam02618 443218005153 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 443218005154 dimerization interface [polypeptide binding]; other site 443218005155 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 443218005156 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443218005157 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443218005158 shikimate binding site; other site 443218005159 NAD(P) binding site [chemical binding]; other site 443218005160 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 443218005161 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443218005162 Tetramer interface [polypeptide binding]; other site 443218005163 active site 443218005164 FMN-binding site [chemical binding]; other site 443218005165 shikimate kinase; Reviewed; Region: aroK; PRK00131 443218005166 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443218005167 ADP binding site [chemical binding]; other site 443218005168 magnesium binding site [ion binding]; other site 443218005169 putative shikimate binding site; other site 443218005170 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443218005171 active site 443218005172 dimer interface [polypeptide binding]; other site 443218005173 metal binding site [ion binding]; metal-binding site 443218005174 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218005175 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218005176 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 443218005177 active site 443218005178 elongation factor P; Validated; Region: PRK00529 443218005179 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443218005180 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443218005181 RNA binding site [nucleotide binding]; other site 443218005182 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443218005183 RNA binding site [nucleotide binding]; other site 443218005184 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 443218005185 putative RNA binding site [nucleotide binding]; other site 443218005186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218005187 active site 443218005188 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443218005189 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443218005190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005191 dihydroorotase; Validated; Region: pyrC; PRK09357 443218005192 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443218005193 active site 443218005194 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443218005195 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 443218005196 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443218005197 catalytic site [active] 443218005198 subunit interface [polypeptide binding]; other site 443218005199 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443218005200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218005201 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218005202 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443218005203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218005204 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218005205 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443218005206 IMP binding site; other site 443218005207 dimer interface [polypeptide binding]; other site 443218005208 interdomain contacts; other site 443218005209 partial ornithine binding site; other site 443218005210 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 443218005211 active site 443218005212 dimer interface [polypeptide binding]; other site 443218005213 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443218005214 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443218005215 catalytic site [active] 443218005216 G-X2-G-X-G-K; other site 443218005217 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 443218005218 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443218005219 Flavoprotein; Region: Flavoprotein; cl08021 443218005220 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 443218005221 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443218005222 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443218005223 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443218005224 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443218005225 primosome assembly protein PriA; Provisional; Region: PRK14873 443218005226 Helix-turn-helix domains; Region: HTH; cl00088 443218005227 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218005228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218005229 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 443218005230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218005231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218005232 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443218005233 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443218005234 putative active site [active] 443218005235 substrate binding site [chemical binding]; other site 443218005236 putative cosubstrate binding site; other site 443218005237 catalytic site [active] 443218005238 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443218005239 substrate binding site [chemical binding]; other site 443218005240 16S rRNA methyltransferase B; Provisional; Region: PRK14902 443218005241 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 443218005242 putative RNA binding site [nucleotide binding]; other site 443218005243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218005244 S-adenosylmethionine binding site [chemical binding]; other site 443218005245 amidase; Provisional; Region: PRK07869 443218005246 Amidase; Region: Amidase; cl11426 443218005247 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 443218005248 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443218005249 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 443218005250 substrate binding site [chemical binding]; other site 443218005251 hexamer interface [polypeptide binding]; other site 443218005252 metal binding site [ion binding]; metal-binding site 443218005253 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443218005254 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443218005255 catalytic motif [active] 443218005256 Zn binding site [ion binding]; other site 443218005257 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218005258 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443218005259 Lumazine binding domain; Region: Lum_binding; pfam00677 443218005260 Lumazine binding domain; Region: Lum_binding; pfam00677 443218005261 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443218005262 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 443218005263 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443218005264 dimerization interface [polypeptide binding]; other site 443218005265 active site 443218005266 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443218005267 homopentamer interface [polypeptide binding]; other site 443218005268 active site 443218005269 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443218005270 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443218005271 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443218005272 GIY-YIG motif/motif A; other site 443218005273 active site 443218005274 catalytic site [active] 443218005275 putative DNA binding site [nucleotide binding]; other site 443218005276 metal binding site [ion binding]; metal-binding site 443218005277 UvrB/uvrC motif; Region: UVR; pfam02151 443218005278 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443218005279 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 443218005280 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 443218005281 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 443218005282 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443218005283 phosphate binding site [ion binding]; other site 443218005284 putative substrate binding pocket [chemical binding]; other site 443218005285 dimer interface [polypeptide binding]; other site 443218005286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443218005287 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443218005288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005289 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 443218005290 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 443218005291 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443218005292 Phosphoglycerate kinase; Region: PGK; pfam00162 443218005293 substrate binding site [chemical binding]; other site 443218005294 hinge regions; other site 443218005295 ADP binding site [chemical binding]; other site 443218005296 catalytic site [active] 443218005297 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443218005298 substrate binding site [chemical binding]; other site 443218005299 dimer interface [polypeptide binding]; other site 443218005300 catalytic triad [active] 443218005301 Preprotein translocase SecG subunit; Region: SecG; cl09123 443218005302 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443218005303 putative active site [active] 443218005304 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443218005305 putative active site [active] 443218005306 transaldolase; Provisional; Region: PRK03903 443218005307 catalytic residue [active] 443218005308 transketolase; Reviewed; Region: PRK05899 443218005309 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218005310 TPP-binding site [chemical binding]; other site 443218005311 dimer interface [polypeptide binding]; other site 443218005312 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218005313 PYR/PP interface [polypeptide binding]; other site 443218005314 dimer interface [polypeptide binding]; other site 443218005315 TPP binding site [chemical binding]; other site 443218005316 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218005317 UbiA prenyltransferase family; Region: UbiA; cl00337 443218005318 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443218005319 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443218005320 NADP binding site [chemical binding]; other site 443218005321 dimer interface [polypeptide binding]; other site 443218005322 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 443218005323 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218005324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218005325 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218005326 Walker A/P-loop; other site 443218005327 ATP binding site [chemical binding]; other site 443218005328 Q-loop/lid; other site 443218005329 ABC transporter signature motif; other site 443218005330 Walker B; other site 443218005331 D-loop; other site 443218005332 H-loop/switch region; other site 443218005333 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443218005334 Predicted transcriptional regulator [Transcription]; Region: COG2345 443218005335 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 443218005336 FeS assembly protein SufB; Region: sufB; TIGR01980 443218005337 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 443218005338 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 443218005339 FeS assembly ATPase SufC; Region: sufC; TIGR01978 443218005340 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 443218005341 Walker A/P-loop; other site 443218005342 ATP binding site [chemical binding]; other site 443218005343 Q-loop/lid; other site 443218005344 ABC transporter signature motif; other site 443218005345 Walker B; other site 443218005346 D-loop; other site 443218005347 H-loop/switch region; other site 443218005348 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218005349 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443218005350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218005351 catalytic residue [active] 443218005352 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443218005353 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443218005354 trimerization site [polypeptide binding]; other site 443218005355 active site 443218005356 Domain of unknown function DUF59; Region: DUF59; cl00941 443218005357 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 443218005358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218005360 classical (c) SDRs; Region: SDR_c; cd05233 443218005361 NAD(P) binding site [chemical binding]; other site 443218005362 active site 443218005363 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218005364 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218005365 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218005366 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218005367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005368 Helix-turn-helix domains; Region: HTH; cl00088 443218005369 aconitate hydratase; Validated; Region: PRK09277 443218005370 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443218005371 substrate binding site [chemical binding]; other site 443218005372 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443218005373 ligand binding site [chemical binding]; other site 443218005374 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443218005375 substrate binding site [chemical binding]; other site 443218005376 NlpC/P60 family; Region: NLPC_P60; cl11438 443218005377 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218005378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005379 Walker A motif; other site 443218005380 ATP binding site [chemical binding]; other site 443218005381 Walker B motif; other site 443218005382 arginine finger; other site 443218005383 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218005384 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218005385 hypothetical protein; Provisional; Region: PRK13685 443218005386 Aerotolerance regulator N-terminal; Region: BatA; cl06567 443218005387 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218005388 metal ion-dependent adhesion site (MIDAS); other site 443218005389 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 443218005390 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443218005391 NAD(P) binding site [chemical binding]; other site 443218005392 homotetramer interface [polypeptide binding]; other site 443218005393 homodimer interface [polypeptide binding]; other site 443218005394 active site 443218005395 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 443218005396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005397 NAD(P) binding site [chemical binding]; other site 443218005398 active site 443218005399 ferrochelatase; Reviewed; Region: hemH; PRK00035 443218005400 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443218005401 C-terminal domain interface [polypeptide binding]; other site 443218005402 active site 443218005403 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443218005404 active site 443218005405 N-terminal domain interface [polypeptide binding]; other site 443218005406 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443218005407 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 443218005408 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 443218005409 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 443218005410 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218005411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005412 Helix-turn-helix domains; Region: HTH; cl00088 443218005413 DNA-binding interface [nucleotide binding]; DNA binding site 443218005414 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218005415 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 443218005416 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 443218005417 heterodimer interface [polypeptide binding]; other site 443218005418 substrate interaction site [chemical binding]; other site 443218005419 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 443218005420 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 443218005421 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 443218005422 active site 443218005423 substrate binding site [chemical binding]; other site 443218005424 coenzyme B12 binding site [chemical binding]; other site 443218005425 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 443218005426 B12 binding site [chemical binding]; other site 443218005427 cobalt ligand [ion binding]; other site 443218005428 membrane ATPase/protein kinase; Provisional; Region: PRK09435 443218005429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005430 GTP/Mg2+ binding site [chemical binding]; other site 443218005431 G5 box; other site 443218005432 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 443218005433 Walker A; other site 443218005434 G1 box; other site 443218005435 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443218005436 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 443218005437 Walker A/P-loop; other site 443218005438 ATP binding site [chemical binding]; other site 443218005439 Q-loop/lid; other site 443218005440 ABC transporter signature motif; other site 443218005441 Walker B; other site 443218005442 D-loop; other site 443218005443 H-loop/switch region; other site 443218005444 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 443218005445 Walker A/P-loop; other site 443218005446 ATP binding site [chemical binding]; other site 443218005447 Q-loop/lid; other site 443218005448 ABC transporter signature motif; other site 443218005449 Walker B; other site 443218005450 D-loop; other site 443218005451 H-loop/switch region; other site 443218005452 Cobalt transport protein; Region: CbiQ; cl00463 443218005453 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 443218005454 active site 443218005455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005456 Helix-turn-helix domains; Region: HTH; cl00088 443218005457 hypothetical protein; Provisional; Region: PRK07877 443218005458 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218005459 dimer interface [polypeptide binding]; other site 443218005460 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218005461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218005462 active site 443218005463 ATP binding site [chemical binding]; other site 443218005464 substrate binding site [chemical binding]; other site 443218005465 activation loop (A-loop); other site 443218005466 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443218005467 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218005468 phosphopeptide binding site; other site 443218005469 Helix-turn-helix domains; Region: HTH; cl00088 443218005470 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218005471 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 443218005472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005474 active site 443218005475 hypothetical protein; Provisional; Region: PRK07906 443218005476 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443218005477 putative metal binding site [ion binding]; other site 443218005478 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443218005479 substrate binding site [chemical binding]; other site 443218005480 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443218005481 quinone interaction residues [chemical binding]; other site 443218005482 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 443218005483 active site 443218005484 catalytic residues [active] 443218005485 FMN binding site [chemical binding]; other site 443218005486 substrate binding site [chemical binding]; other site 443218005487 Uncharacterized conserved protein [Function unknown]; Region: COG3391 443218005488 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 443218005489 heme binding pocket [chemical binding]; other site 443218005490 heme ligand [chemical binding]; other site 443218005491 Bacitracin resistance protein BacA; Region: BacA; cl00858 443218005492 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218005493 catalytic core [active] 443218005494 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 443218005495 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 443218005496 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443218005497 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443218005498 active site 443218005499 HIGH motif; other site 443218005500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218005501 active site 443218005502 KMSKS motif; other site 443218005503 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 443218005504 putative tRNA binding surface [nucleotide binding]; other site 443218005505 PAC2 family; Region: PAC2; cl00847 443218005506 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 443218005507 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 443218005508 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 443218005509 substrate binding pocket [chemical binding]; other site 443218005510 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 443218005511 B12 binding site [chemical binding]; other site 443218005512 cobalt ligand [ion binding]; other site 443218005513 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 443218005514 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443218005515 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218005516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218005517 motif II; other site 443218005518 Protein of unknown function (DUF419); Region: DUF419; cl15265 443218005519 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443218005520 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 443218005521 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 443218005522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218005523 active site 443218005524 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 443218005525 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 443218005526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005527 Cupin domain; Region: Cupin_2; cl09118 443218005528 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 443218005529 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 443218005530 NifU-like domain; Region: NifU; cl00484 443218005531 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218005532 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 443218005533 nickel binding site [ion binding]; other site 443218005534 HupF/HypC family; Region: HupF_HypC; cl00394 443218005535 Acylphosphatase; Region: Acylphosphatase; cl00551 443218005536 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 443218005537 HypF finger; Region: zf-HYPF; pfam07503 443218005538 HypF finger; Region: zf-HYPF; pfam07503 443218005539 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 443218005540 HupF/HypC family; Region: HupF_HypC; cl00394 443218005541 Hydrogenase formation hypA family; Region: HypD; cl12072 443218005542 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 443218005543 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 443218005544 dimerization interface [polypeptide binding]; other site 443218005545 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 443218005546 ATP binding site [chemical binding]; other site 443218005547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218005548 Helix-turn-helix domains; Region: HTH; cl00088 443218005549 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 443218005550 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443218005551 ATP phosphoribosyltransferase; Region: HisG; cl15266 443218005552 HisG, C-terminal domain; Region: HisG_C; cl06867 443218005553 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218005554 Helix-turn-helix domains; Region: HTH; cl00088 443218005555 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 443218005556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218005557 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218005558 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443218005559 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443218005560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218005561 S-adenosylmethionine binding site [chemical binding]; other site 443218005562 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 443218005563 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 443218005564 active site 443218005565 nucleophile elbow; other site 443218005566 amino acid transporter; Region: 2A0306; TIGR00909 443218005567 Spore germination protein; Region: Spore_permease; cl15802 443218005568 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443218005569 active site 443218005570 Helix-turn-helix domains; Region: HTH; cl00088 443218005571 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443218005572 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443218005573 active site 443218005574 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443218005575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005576 ATP binding site [chemical binding]; other site 443218005577 putative Mg++ binding site [ion binding]; other site 443218005578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005579 nucleotide binding region [chemical binding]; other site 443218005580 ATP-binding site [chemical binding]; other site 443218005581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443218005582 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 443218005583 active site 443218005584 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218005585 hydrophobic ligand binding site; other site 443218005586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005587 Uncharacterized conserved protein [Function unknown]; Region: COG4715 443218005588 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 443218005589 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 443218005590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005591 ATP binding site [chemical binding]; other site 443218005592 putative Mg++ binding site [ion binding]; other site 443218005593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005594 nucleotide binding region [chemical binding]; other site 443218005595 ATP-binding site [chemical binding]; other site 443218005596 proteasome ATPase; Region: pup_AAA; TIGR03689 443218005597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218005598 Walker A motif; other site 443218005599 ATP binding site [chemical binding]; other site 443218005600 Walker B motif; other site 443218005601 arginine finger; other site 443218005602 Pup-ligase protein; Region: Pup_ligase; cl15463 443218005603 Pup-like protein; Region: Pup; cl05289 443218005604 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443218005605 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443218005606 active site 443218005607 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 443218005608 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 443218005609 active site 443218005610 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443218005611 active site 443218005612 Pup-ligase protein; Region: Pup_ligase; cl15463 443218005613 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218005614 WYL domain; Region: WYL; cl14852 443218005615 WYL domain; Region: WYL; cl14852 443218005616 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 443218005617 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 443218005618 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 443218005619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218005620 ATP binding site [chemical binding]; other site 443218005621 putative Mg++ binding site [ion binding]; other site 443218005622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218005623 nucleotide binding region [chemical binding]; other site 443218005624 ATP-binding site [chemical binding]; other site 443218005625 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443218005626 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 443218005627 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 443218005628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218005629 tetrameric interface [polypeptide binding]; other site 443218005630 NAD binding site [chemical binding]; other site 443218005631 catalytic residues [active] 443218005632 5'-3' exonuclease; Region: 53EXOc; smart00475 443218005633 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443218005634 active site 443218005635 metal binding site 1 [ion binding]; metal-binding site 443218005636 putative 5' ssDNA interaction site; other site 443218005637 metal binding site 3; metal-binding site 443218005638 metal binding site 2 [ion binding]; metal-binding site 443218005639 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443218005640 putative DNA binding site [nucleotide binding]; other site 443218005641 putative metal binding site [ion binding]; other site 443218005642 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218005643 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218005644 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 443218005645 active site 443218005646 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218005647 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218005648 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218005649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005650 NAD(P) binding site [chemical binding]; other site 443218005651 active site 443218005652 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218005653 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218005654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218005655 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218005656 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218005657 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 443218005658 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 443218005659 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218005660 putative active site [active] 443218005661 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 443218005662 active site 443218005663 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218005664 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 443218005665 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443218005666 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218005667 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218005668 VPS10 domain; Region: VPS10; smart00602 443218005669 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218005670 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218005671 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218005672 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218005673 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 443218005674 Precorrin-8X methylmutase; Region: CbiC; pfam02570 443218005675 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443218005676 putative homotetramer interface [polypeptide binding]; other site 443218005677 putative homodimer interface [polypeptide binding]; other site 443218005678 putative allosteric switch controlling residues; other site 443218005679 putative metal binding site [ion binding]; other site 443218005680 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443218005681 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443218005682 metal-binding site [ion binding] 443218005683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443218005684 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218005685 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443218005686 metal-binding site [ion binding] 443218005687 Domain of unknown function (DUF305); Region: DUF305; cl15795 443218005688 precorrin-3B synthase; Region: CobG; TIGR02435 443218005689 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218005690 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218005691 AMP-binding enzyme; Region: AMP-binding; cl15778 443218005692 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218005693 metabolite-proton symporter; Region: 2A0106; TIGR00883 443218005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218005695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218005696 DNA binding residues [nucleotide binding] 443218005697 dimerization interface [polypeptide binding]; other site 443218005698 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 443218005699 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443218005700 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 443218005701 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 443218005702 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443218005703 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443218005704 shikimate binding site; other site 443218005705 NAD(P) binding site [chemical binding]; other site 443218005706 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218005707 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218005708 Walker A/P-loop; other site 443218005709 ATP binding site [chemical binding]; other site 443218005710 Q-loop/lid; other site 443218005711 ABC transporter signature motif; other site 443218005712 Walker B; other site 443218005713 D-loop; other site 443218005714 H-loop/switch region; other site 443218005715 TOBE domain; Region: TOBE_2; cl01440 443218005716 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218005717 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005718 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 443218005719 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 443218005720 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 443218005721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218005722 Histidine kinase; Region: HisKA_3; pfam07730 443218005723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218005724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218005725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218005726 active site 443218005727 phosphorylation site [posttranslational modification] 443218005728 intermolecular recognition site; other site 443218005729 dimerization interface [polypeptide binding]; other site 443218005730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218005731 dimerization interface [polypeptide binding]; other site 443218005732 DNA binding residues [nucleotide binding] 443218005733 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 443218005734 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443218005735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218005736 active site 443218005737 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 443218005738 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443218005739 putative active site [active] 443218005740 catalytic triad [active] 443218005741 putative dimer interface [polypeptide binding]; other site 443218005742 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443218005743 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443218005744 Ligand binding site; other site 443218005745 Putative Catalytic site; other site 443218005746 DXD motif; other site 443218005747 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 443218005748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218005749 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218005750 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 443218005751 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 443218005752 active site 443218005753 putative substrate binding pocket [chemical binding]; other site 443218005754 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218005755 hydrophobic ligand binding site; other site 443218005756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005757 Peptidase family M48; Region: Peptidase_M48; cl12018 443218005758 LemA family; Region: LemA; cl00742 443218005759 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 443218005760 alpha-gamma subunit interface [polypeptide binding]; other site 443218005761 beta-gamma subunit interface [polypeptide binding]; other site 443218005762 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 443218005763 gamma-beta subunit interface [polypeptide binding]; other site 443218005764 alpha-beta subunit interface [polypeptide binding]; other site 443218005765 urease subunit alpha; Reviewed; Region: ureC; PRK13206 443218005766 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 443218005767 subunit interactions [polypeptide binding]; other site 443218005768 active site 443218005769 flap region; other site 443218005770 UreF; Region: UreF; pfam01730 443218005771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005772 UreD urease accessory protein; Region: UreD; cl00530 443218005773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 443218005774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218005775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005776 dimer interface [polypeptide binding]; other site 443218005777 conserved gate region; other site 443218005778 putative PBP binding loops; other site 443218005779 ABC-ATPase subunit interface; other site 443218005780 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443218005781 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 443218005782 Walker A/P-loop; other site 443218005783 ATP binding site [chemical binding]; other site 443218005784 Q-loop/lid; other site 443218005785 ABC transporter signature motif; other site 443218005786 Walker B; other site 443218005787 D-loop; other site 443218005788 H-loop/switch region; other site 443218005789 NMT1-like family; Region: NMT1_2; cl15260 443218005790 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 443218005791 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443218005792 putative active site [active] 443218005793 Predicted esterase [General function prediction only]; Region: COG0627 443218005794 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 443218005795 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 443218005796 Walker A/P-loop; other site 443218005797 ATP binding site [chemical binding]; other site 443218005798 Q-loop/lid; other site 443218005799 ABC transporter signature motif; other site 443218005800 Walker B; other site 443218005801 D-loop; other site 443218005802 H-loop/switch region; other site 443218005803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005804 dimer interface [polypeptide binding]; other site 443218005805 conserved gate region; other site 443218005806 putative PBP binding loops; other site 443218005807 ABC-ATPase subunit interface; other site 443218005808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218005809 dimer interface [polypeptide binding]; other site 443218005810 conserved gate region; other site 443218005811 putative PBP binding loops; other site 443218005812 ABC-ATPase subunit interface; other site 443218005813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218005814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218005815 substrate binding pocket [chemical binding]; other site 443218005816 membrane-bound complex binding site; other site 443218005817 hinge residues; other site 443218005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218005819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218005820 putative substrate translocation pore; other site 443218005821 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218005822 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218005823 active site 443218005824 ATP binding site [chemical binding]; other site 443218005825 substrate binding site [chemical binding]; other site 443218005826 activation loop (A-loop); other site 443218005827 kelch-like protein; Provisional; Region: PHA03098 443218005828 Kelch motif; Region: Kelch_1; cl02701 443218005829 Kelch motif; Region: Kelch_1; cl02701 443218005830 kelch-like protein; Provisional; Region: PHA03098 443218005831 kelch-like protein; Provisional; Region: PHA03098 443218005832 Kelch motif; Region: Kelch_1; cl02701 443218005833 Kelch motif; Region: Kelch_1; cl02701 443218005834 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 443218005835 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 443218005836 [4Fe-4S] binding site [ion binding]; other site 443218005837 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218005838 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218005839 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218005840 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 443218005841 molybdopterin cofactor binding site; other site 443218005842 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 443218005843 4Fe-4S binding domain; Region: Fer4; cl02805 443218005844 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 443218005845 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 443218005846 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218005847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005848 NAD(P) binding site [chemical binding]; other site 443218005849 active site 443218005850 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 443218005851 dimer interface [polypeptide binding]; other site 443218005852 putative tRNA-binding site [nucleotide binding]; other site 443218005853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443218005854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 443218005855 nudix motif; other site 443218005856 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218005857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005858 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218005859 Walker A/P-loop; other site 443218005860 ATP binding site [chemical binding]; other site 443218005861 Q-loop/lid; other site 443218005862 ABC transporter signature motif; other site 443218005863 Walker B; other site 443218005864 D-loop; other site 443218005865 H-loop/switch region; other site 443218005866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218005867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005868 Walker A/P-loop; other site 443218005869 ATP binding site [chemical binding]; other site 443218005870 Q-loop/lid; other site 443218005871 ABC transporter signature motif; other site 443218005872 Walker B; other site 443218005873 D-loop; other site 443218005874 H-loop/switch region; other site 443218005875 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 443218005876 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 443218005877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218005878 Family description; Region: UvrD_C_2; cl15862 443218005879 probable methyltransferase; Region: TIGR03438 443218005880 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 443218005881 TIGR03442 family protein; Region: TIGR03442 443218005882 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 443218005883 putative active site [active] 443218005884 putative dimer interface [polypeptide binding]; other site 443218005885 TIGR03440 family protein; Region: unchr_TIGR03440 443218005886 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 443218005887 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218005888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218005889 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218005890 Di-iron ligands [ion binding]; other site 443218005891 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 443218005892 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 443218005893 putative NAD(P) binding site [chemical binding]; other site 443218005894 putative substrate binding site [chemical binding]; other site 443218005895 catalytic Zn binding site [ion binding]; other site 443218005896 structural Zn binding site [ion binding]; other site 443218005897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005898 GAF domain; Region: GAF_2; pfam13185 443218005899 GAF domain; Region: GAF; cl15785 443218005900 GAF domain; Region: GAF; cl15785 443218005901 Histidine kinase; Region: HisKA_3; pfam07730 443218005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218005903 ATP binding site [chemical binding]; other site 443218005904 Mg2+ binding site [ion binding]; other site 443218005905 G-X-G motif; other site 443218005906 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443218005907 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443218005908 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443218005909 phosphoenolpyruvate synthase; Validated; Region: PRK06464 443218005910 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 443218005911 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 443218005912 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218005913 hypothetical protein; Provisional; Region: PRK07877 443218005914 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218005915 dimer interface [polypeptide binding]; other site 443218005916 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 443218005917 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218005918 Di-iron ligands [ion binding]; other site 443218005919 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 443218005920 Cupin domain; Region: Cupin_2; cl09118 443218005921 high affinity sulphate transporter 1; Region: sulP; TIGR00815 443218005922 Sulfate transporter family; Region: Sulfate_transp; cl15842 443218005923 Sulfate transporter family; Region: Sulfate_transp; cl15842 443218005924 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443218005925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218005926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218005927 Ligand Binding Site [chemical binding]; other site 443218005928 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443218005929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218005930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218005931 active site 443218005932 metal binding site [ion binding]; metal-binding site 443218005933 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218005934 substrate binding site [chemical binding]; other site 443218005935 oxyanion hole (OAH) forming residues; other site 443218005936 trimer interface [polypeptide binding]; other site 443218005937 HSP90 family protein; Provisional; Region: PRK14083 443218005938 Predicted acetyltransferase [General function prediction only]; Region: COG3153 443218005939 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218005940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218005941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218005942 putative substrate translocation pore; other site 443218005943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218005944 Helix-turn-helix domains; Region: HTH; cl00088 443218005945 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 443218005946 putative dimerization interface [polypeptide binding]; other site 443218005947 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443218005948 active site 443218005949 metal binding site [ion binding]; metal-binding site 443218005950 nudix motif; other site 443218005951 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 443218005952 active site 443218005953 putative substrate binding region [chemical binding]; other site 443218005954 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 443218005955 oxidoreductase; Provisional; Region: PRK12743 443218005956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218005957 NAD(P) binding site [chemical binding]; other site 443218005958 active site 443218005959 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218005960 active site 443218005961 nucleophile elbow; other site 443218005962 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218005963 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443218005964 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 443218005965 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218005966 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443218005967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218005968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218005969 PAS domain; Region: PAS_9; pfam13426 443218005970 putative active site [active] 443218005971 heme pocket [chemical binding]; other site 443218005972 ANTAR domain; Region: ANTAR; cl04297 443218005973 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 443218005974 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 443218005975 Helix-turn-helix domains; Region: HTH; cl00088 443218005976 FAD binding domain; Region: FAD_binding_4; pfam01565 443218005977 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443218005978 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 443218005979 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 443218005980 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218005981 ring oligomerisation interface [polypeptide binding]; other site 443218005982 ATP/Mg binding site [chemical binding]; other site 443218005983 stacking interactions; other site 443218005984 hinge regions; other site 443218005985 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443218005986 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 443218005987 NAD binding site [chemical binding]; other site 443218005988 substrate binding site [chemical binding]; other site 443218005989 catalytic Zn binding site [ion binding]; other site 443218005990 structural Zn binding site [ion binding]; other site 443218005991 Domain of unknown function DUF59; Region: DUF59; cl00941 443218005992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 443218005993 active site 443218005994 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 443218005995 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 443218005996 dimerization interface [polypeptide binding]; other site 443218005997 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 443218005998 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218005999 catalytic loop [active] 443218006000 iron binding site [ion binding]; other site 443218006001 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 443218006002 FAD binding pocket [chemical binding]; other site 443218006003 FAD binding motif [chemical binding]; other site 443218006004 phosphate binding motif [ion binding]; other site 443218006005 beta-alpha-beta structure motif; other site 443218006006 NAD binding pocket [chemical binding]; other site 443218006007 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 443218006008 dimerization interface [polypeptide binding]; other site 443218006009 putative path to active site cavity [active] 443218006010 diiron center [ion binding]; other site 443218006011 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 443218006012 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 443218006013 Helix-turn-helix domains; Region: HTH; cl00088 443218006014 LysE type translocator; Region: LysE; cl00565 443218006015 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218006016 Helix-turn-helix domains; Region: HTH; cl00088 443218006017 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 443218006018 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218006019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218006020 Helix-turn-helix domains; Region: HTH; cl00088 443218006021 Helix-turn-helix domains; Region: HTH; cl00088 443218006022 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218006023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006024 Helix-turn-helix domains; Region: HTH; cl00088 443218006025 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 443218006026 putative hydrophobic ligand binding site [chemical binding]; other site 443218006027 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443218006028 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218006029 homodimer interface [polypeptide binding]; other site 443218006030 active site 443218006031 TDP-binding site; other site 443218006032 acceptor substrate-binding pocket; other site 443218006033 RNA polymerase factor sigma-70; Validated; Region: PRK08241 443218006034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218006036 DNA binding residues [nucleotide binding] 443218006037 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218006038 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218006039 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218006040 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 443218006041 putative NAD(P) binding site [chemical binding]; other site 443218006042 Lipase maturation factor; Region: LMF1; pfam06762 443218006043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006044 Helix-turn-helix domains; Region: HTH; cl00088 443218006045 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218006046 Helix-turn-helix domains; Region: HTH; cl00088 443218006047 WHG domain; Region: WHG; pfam13305 443218006048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006050 SCP-2 sterol transfer family; Region: SCP2; cl01225 443218006051 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443218006052 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 443218006053 SCP-2 sterol transfer family; Region: SCP2; cl01225 443218006054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006055 H-loop/switch region; other site 443218006056 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218006057 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006058 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218006059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218006060 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006061 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006062 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006063 Helix-turn-helix domains; Region: HTH; cl00088 443218006064 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218006065 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218006066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006067 substrate binding site [chemical binding]; other site 443218006068 oxyanion hole (OAH) forming residues; other site 443218006069 trimer interface [polypeptide binding]; other site 443218006070 enoyl-CoA hydratase; Provisional; Region: PRK06563 443218006071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006072 substrate binding site [chemical binding]; other site 443218006073 oxyanion hole (OAH) forming residues; other site 443218006074 trimer interface [polypeptide binding]; other site 443218006075 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 443218006076 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218006077 dimer interface [polypeptide binding]; other site 443218006078 active site 443218006079 Helix-turn-helix domains; Region: HTH; cl00088 443218006080 putative transcriptional regulator; Provisional; Region: PRK11640 443218006081 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443218006082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006083 Helix-turn-helix domains; Region: HTH; cl00088 443218006084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218006085 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 443218006086 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 443218006087 active site 443218006088 FMN binding site [chemical binding]; other site 443218006089 2,4-decadienoyl-CoA binding site; other site 443218006090 catalytic residue [active] 443218006091 4Fe-4S cluster binding site [ion binding]; other site 443218006092 short chain dehydrogenase; Provisional; Region: PRK12827 443218006093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006094 active site 443218006095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006096 Helix-turn-helix domains; Region: HTH; cl00088 443218006097 Helix-turn-helix domains; Region: HTH; cl00088 443218006098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006099 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006100 short chain dehydrogenase; Provisional; Region: PRK06181 443218006101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006102 NAD(P) binding site [chemical binding]; other site 443218006103 active site 443218006104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006106 Helix-turn-helix domains; Region: HTH; cl00088 443218006107 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218006108 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443218006109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006110 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218006115 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218006116 NAD(P) binding site [chemical binding]; other site 443218006117 catalytic residues [active] 443218006118 short chain dehydrogenase; Provisional; Region: PRK07825 443218006119 classical (c) SDRs; Region: SDR_c; cd05233 443218006120 NAD(P) binding site [chemical binding]; other site 443218006121 active site 443218006122 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218006123 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006124 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006125 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006126 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 443218006127 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 443218006128 active site 443218006129 catalytic residues [active] 443218006130 L-arabinose isomerase; Provisional; Region: PRK02929 443218006131 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 443218006132 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443218006133 trimer interface [polypeptide binding]; other site 443218006134 substrate binding site [chemical binding]; other site 443218006135 Mn binding site [ion binding]; other site 443218006136 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 443218006137 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 443218006138 intersubunit interface [polypeptide binding]; other site 443218006139 active site 443218006140 Zn2+ binding site [ion binding]; other site 443218006141 ribulokinase; Provisional; Region: PRK04123 443218006142 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 443218006143 putative N- and C-terminal domain interface [polypeptide binding]; other site 443218006144 putative active site [active] 443218006145 putative MgATP binding site [chemical binding]; other site 443218006146 catalytic site [active] 443218006147 metal binding site [ion binding]; metal-binding site 443218006148 carbohydrate binding site [chemical binding]; other site 443218006149 homodimer interface [polypeptide binding]; other site 443218006150 lac repressor; Reviewed; Region: lacI; PRK09526 443218006151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218006152 DNA binding site [nucleotide binding] 443218006153 domain linker motif; other site 443218006154 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443218006155 ligand binding site [chemical binding]; other site 443218006156 dimerization interface (open form) [polypeptide binding]; other site 443218006157 dimerization interface (closed form) [polypeptide binding]; other site 443218006158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218006159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 443218006160 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 443218006161 putative active site [active] 443218006162 catalytic triad [active] 443218006163 putative dimer interface [polypeptide binding]; other site 443218006164 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 443218006165 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443218006166 ligand binding site [chemical binding]; other site 443218006167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443218006168 TM-ABC transporter signature motif; other site 443218006169 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 443218006170 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 443218006171 Walker A/P-loop; other site 443218006172 ATP binding site [chemical binding]; other site 443218006173 Q-loop/lid; other site 443218006174 ABC transporter signature motif; other site 443218006175 Walker B; other site 443218006176 D-loop; other site 443218006177 H-loop/switch region; other site 443218006178 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 443218006179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218006180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443218006181 active site 443218006182 catalytic tetrad [active] 443218006183 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218006184 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218006185 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 443218006186 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 443218006187 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218006188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218006189 motif II; other site 443218006190 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443218006191 homotrimer interaction site [polypeptide binding]; other site 443218006192 putative active site [active] 443218006193 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 443218006194 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443218006195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218006196 catalytic residue [active] 443218006197 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218006198 classical (c) SDRs; Region: SDR_c; cd05233 443218006199 NAD(P) binding site [chemical binding]; other site 443218006200 active site 443218006201 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 443218006202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218006203 DNA-binding site [nucleotide binding]; DNA binding site 443218006204 FCD domain; Region: FCD; cl11656 443218006205 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443218006206 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 443218006207 putative active site [active] 443218006208 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218006209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 443218006210 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 443218006211 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218006212 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006213 hydrophobic ligand binding site; other site 443218006214 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006215 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218006216 FMN-binding pocket [chemical binding]; other site 443218006217 flavin binding motif; other site 443218006218 phosphate binding motif [ion binding]; other site 443218006219 beta-alpha-beta structure motif; other site 443218006220 NAD binding pocket [chemical binding]; other site 443218006221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006222 catalytic loop [active] 443218006223 iron binding site [ion binding]; other site 443218006224 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006225 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006226 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 443218006227 short chain dehydrogenase; Provisional; Region: PRK07825 443218006228 classical (c) SDRs; Region: SDR_c; cd05233 443218006229 NAD(P) binding site [chemical binding]; other site 443218006230 active site 443218006231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006232 Helix-turn-helix domains; Region: HTH; cl00088 443218006233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218006234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218006235 active site 443218006236 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218006237 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006238 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218006239 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 443218006240 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 443218006241 NAD(P) binding site [chemical binding]; other site 443218006242 catalytic residues [active] 443218006243 short chain dehydrogenase; Provisional; Region: PRK08278 443218006244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006245 NAD(P) binding site [chemical binding]; other site 443218006246 active site 443218006247 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218006248 CoenzymeA binding site [chemical binding]; other site 443218006249 subunit interaction site [polypeptide binding]; other site 443218006250 PHB binding site; other site 443218006251 Helix-turn-helix domains; Region: HTH; cl00088 443218006252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006253 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 443218006254 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 443218006255 putative active site [active] 443218006256 putative FMN binding site [chemical binding]; other site 443218006257 putative substrate binding site [chemical binding]; other site 443218006258 putative catalytic residue [active] 443218006259 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 443218006260 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 443218006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006262 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218006263 classical (c) SDRs; Region: SDR_c; cd05233 443218006264 NAD(P) binding site [chemical binding]; other site 443218006265 active site 443218006266 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 443218006267 Helix-turn-helix domains; Region: HTH; cl00088 443218006268 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218006269 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218006270 putative NAD(P) binding site [chemical binding]; other site 443218006271 Helix-turn-helix domains; Region: HTH; cl00088 443218006272 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006273 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218006274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218006275 S-adenosylmethionine binding site [chemical binding]; other site 443218006276 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218006277 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443218006278 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 443218006279 conserved cys residue [active] 443218006280 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 443218006281 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 443218006282 conserved cys residue [active] 443218006283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006284 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 443218006285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006286 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 443218006287 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 443218006288 putative ligand binding residues [chemical binding]; other site 443218006289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218006290 ABC-ATPase subunit interface; other site 443218006291 dimer interface [polypeptide binding]; other site 443218006292 putative PBP binding regions; other site 443218006293 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 443218006294 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218006295 Walker A/P-loop; other site 443218006296 ATP binding site [chemical binding]; other site 443218006297 Q-loop/lid; other site 443218006298 ABC transporter signature motif; other site 443218006299 Walker B; other site 443218006300 D-loop; other site 443218006301 H-loop/switch region; other site 443218006302 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218006304 Coenzyme A binding pocket [chemical binding]; other site 443218006305 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 443218006306 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218006307 NAD binding site [chemical binding]; other site 443218006308 substrate binding site [chemical binding]; other site 443218006309 putative active site [active] 443218006310 Cupin domain; Region: Cupin_2; cl09118 443218006311 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006313 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 443218006314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218006315 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218006316 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006317 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218006319 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 443218006320 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 443218006321 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 443218006322 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 443218006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006324 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 443218006325 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218006326 putative active site [active] 443218006327 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218006328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218006329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006330 ATP binding site [chemical binding]; other site 443218006331 Mg2+ binding site [ion binding]; other site 443218006332 G-X-G motif; other site 443218006333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218006334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006335 active site 443218006336 phosphorylation site [posttranslational modification] 443218006337 intermolecular recognition site; other site 443218006338 dimerization interface [polypeptide binding]; other site 443218006339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006340 DNA binding residues [nucleotide binding] 443218006341 dimerization interface [polypeptide binding]; other site 443218006342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006344 ABC transporter signature motif; other site 443218006345 ABC transporter signature motif; other site 443218006346 Walker B; other site 443218006347 Walker B; other site 443218006348 D-loop; other site 443218006349 D-loop; other site 443218006350 H-loop/switch region; other site 443218006351 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 443218006352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443218006353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218006354 Coenzyme A binding pocket [chemical binding]; other site 443218006355 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 443218006356 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 443218006357 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218006358 DNA binding residues [nucleotide binding] 443218006359 putative dimer interface [polypeptide binding]; other site 443218006360 HEAT repeats; Region: HEAT_2; pfam13646 443218006361 hypothetical protein; Provisional; Region: PRK06834 443218006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006364 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 443218006365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006366 Helix-turn-helix domains; Region: HTH; cl00088 443218006367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218006369 putative substrate translocation pore; other site 443218006370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218006371 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006373 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218006374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006376 hydrophobic ligand binding site; other site 443218006377 hypothetical protein; Validated; Region: PRK07198 443218006378 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 443218006379 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443218006380 dimerization interface [polypeptide binding]; other site 443218006381 active site 443218006382 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 443218006383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218006384 active site 443218006385 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 443218006386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218006387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218006388 DNA binding residues [nucleotide binding] 443218006389 dimerization interface [polypeptide binding]; other site 443218006390 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443218006391 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443218006392 NAD binding site [chemical binding]; other site 443218006393 catalytic Zn binding site [ion binding]; other site 443218006394 substrate binding site [chemical binding]; other site 443218006395 structural Zn binding site [ion binding]; other site 443218006396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218006397 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443218006398 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218006399 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218006400 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443218006401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218006403 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218006404 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006405 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006408 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218006409 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218006410 active site 443218006411 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 443218006412 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443218006413 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443218006414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006415 Walker A/P-loop; other site 443218006416 ATP binding site [chemical binding]; other site 443218006417 Q-loop/lid; other site 443218006418 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 443218006419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006420 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443218006421 Walker A/P-loop; other site 443218006422 ATP binding site [chemical binding]; other site 443218006423 Q-loop/lid; other site 443218006424 ABC transporter signature motif; other site 443218006425 Walker B; other site 443218006426 D-loop; other site 443218006427 H-loop/switch region; other site 443218006428 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218006429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006433 YCII-related domain; Region: YCII; cl00999 443218006434 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218006435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218006437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218006438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006439 active site 443218006440 phosphorylation site [posttranslational modification] 443218006441 intermolecular recognition site; other site 443218006442 dimerization interface [polypeptide binding]; other site 443218006443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218006444 DNA binding site [nucleotide binding] 443218006445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218006446 dimerization interface [polypeptide binding]; other site 443218006447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218006448 dimer interface [polypeptide binding]; other site 443218006449 phosphorylation site [posttranslational modification] 443218006450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006451 ATP binding site [chemical binding]; other site 443218006452 Mg2+ binding site [ion binding]; other site 443218006453 G-X-G motif; other site 443218006454 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 443218006455 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218006456 DNA binding residues [nucleotide binding] 443218006457 TOBE domain; Region: TOBE_2; cl01440 443218006458 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443218006459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006461 dimer interface [polypeptide binding]; other site 443218006462 conserved gate region; other site 443218006463 putative PBP binding loops; other site 443218006464 ABC-ATPase subunit interface; other site 443218006465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006466 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218006467 Walker A/P-loop; other site 443218006468 ATP binding site [chemical binding]; other site 443218006469 Q-loop/lid; other site 443218006470 ABC transporter signature motif; other site 443218006471 Walker B; other site 443218006472 D-loop; other site 443218006473 H-loop/switch region; other site 443218006474 TOBE domain; Region: TOBE_2; cl01440 443218006475 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 443218006476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218006477 YaeQ protein; Region: YaeQ; cl01913 443218006478 NMT1-like family; Region: NMT1_2; cl15260 443218006479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443218006480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218006481 dimer interface [polypeptide binding]; other site 443218006482 phosphorylation site [posttranslational modification] 443218006483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006484 Mg2+ binding site [ion binding]; other site 443218006485 G-X-G motif; other site 443218006486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218006487 active site 443218006488 dimerization interface [polypeptide binding]; other site 443218006489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218006490 DNA binding site [nucleotide binding] 443218006491 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443218006492 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443218006493 transmembrane helices; other site 443218006494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218006495 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218006496 active site 443218006497 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218006498 Helix-turn-helix domains; Region: HTH; cl00088 443218006499 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 443218006500 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443218006501 metal binding site 2 [ion binding]; metal-binding site 443218006502 putative DNA binding helix; other site 443218006503 metal binding site 1 [ion binding]; metal-binding site 443218006504 dimer interface [polypeptide binding]; other site 443218006505 structural Zn2+ binding site [ion binding]; other site 443218006506 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 443218006507 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 443218006508 dimer interface [polypeptide binding]; other site 443218006509 active site 443218006510 heme binding site [chemical binding]; other site 443218006511 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 443218006512 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 443218006513 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 443218006514 Protein of unknown function (DUF429); Region: DUF429; cl12046 443218006515 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218006516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006517 molybdopterin cofactor binding site; other site 443218006518 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218006519 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218006520 putative molybdopterin cofactor binding site; other site 443218006521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006522 trimer interface [polypeptide binding]; other site 443218006523 enoyl-CoA hydratase; Provisional; Region: PRK07827 443218006524 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 443218006525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006527 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 443218006528 putative hydrophobic ligand binding site [chemical binding]; other site 443218006529 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218006530 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218006531 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218006532 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006533 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218006534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006535 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218006536 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218006537 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 443218006538 NAD(P) binding site [chemical binding]; other site 443218006539 catalytic residues [active] 443218006540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218006541 putative acyl-acceptor binding pocket; other site 443218006542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006543 Helix-turn-helix domains; Region: HTH; cl00088 443218006544 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006545 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006547 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218006548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006550 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218006551 Helix-turn-helix domains; Region: HTH; cl00088 443218006552 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218006553 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006554 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218006555 FMN-binding pocket [chemical binding]; other site 443218006556 flavin binding motif; other site 443218006557 phosphate binding motif [ion binding]; other site 443218006558 beta-alpha-beta structure motif; other site 443218006559 NAD binding pocket [chemical binding]; other site 443218006560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006561 catalytic loop [active] 443218006562 iron binding site [ion binding]; other site 443218006563 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218006564 iron-sulfur cluster [ion binding]; other site 443218006565 [2Fe-2S] cluster binding site [ion binding]; other site 443218006566 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218006567 Helix-turn-helix domains; Region: HTH; cl00088 443218006568 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218006569 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006570 FAD binding pocket [chemical binding]; other site 443218006571 FAD binding motif [chemical binding]; other site 443218006572 phosphate binding motif [ion binding]; other site 443218006573 beta-alpha-beta structure motif; other site 443218006574 NAD binding pocket [chemical binding]; other site 443218006575 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006576 catalytic loop [active] 443218006577 iron binding site [ion binding]; other site 443218006578 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218006579 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218006580 putative di-iron ligands [ion binding]; other site 443218006581 Protein of unknown function (DUF419); Region: DUF419; cl15265 443218006582 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218006583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218006585 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218006586 DNA binding site [nucleotide binding] 443218006587 active site 443218006588 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 443218006589 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 443218006590 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 443218006591 MOSC domain; Region: MOSC; pfam03473 443218006592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218006593 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 443218006594 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218006595 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 443218006596 Walker A/P-loop; other site 443218006597 ATP binding site [chemical binding]; other site 443218006598 Q-loop/lid; other site 443218006599 ABC transporter signature motif; other site 443218006600 Walker B; other site 443218006601 D-loop; other site 443218006602 H-loop/switch region; other site 443218006603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218006604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218006605 substrate binding pocket [chemical binding]; other site 443218006606 membrane-bound complex binding site; other site 443218006607 hinge residues; other site 443218006608 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443218006609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006610 dimer interface [polypeptide binding]; other site 443218006611 conserved gate region; other site 443218006612 putative PBP binding loops; other site 443218006613 ABC-ATPase subunit interface; other site 443218006614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006615 dimer interface [polypeptide binding]; other site 443218006616 conserved gate region; other site 443218006617 putative PBP binding loops; other site 443218006618 ABC-ATPase subunit interface; other site 443218006619 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218006620 hydrophobic ligand binding site; other site 443218006621 acyl-CoA synthetase; Validated; Region: PRK07788 443218006622 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006623 AMP-binding enzyme; Region: AMP-binding; cl15778 443218006624 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218006625 putative acyl-acceptor binding pocket; other site 443218006626 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218006627 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218006628 DNA binding residues [nucleotide binding] 443218006629 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006631 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218006632 classical (c) SDRs; Region: SDR_c; cd05233 443218006633 NAD(P) binding site [chemical binding]; other site 443218006634 active site 443218006635 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006636 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218006637 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218006638 FAD binding pocket [chemical binding]; other site 443218006639 FAD binding motif [chemical binding]; other site 443218006640 phosphate binding motif [ion binding]; other site 443218006641 beta-alpha-beta structure motif; other site 443218006642 NAD(p) ribose binding residues [chemical binding]; other site 443218006643 NAD binding pocket [chemical binding]; other site 443218006644 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218006645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006646 catalytic loop [active] 443218006647 iron binding site [ion binding]; other site 443218006648 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 443218006649 classical (c) SDRs; Region: SDR_c; cd05233 443218006650 NAD(P) binding site [chemical binding]; other site 443218006651 active site 443218006652 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218006653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443218006654 active site 443218006655 Helix-turn-helix domains; Region: HTH; cl00088 443218006656 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 443218006657 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218006658 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 443218006659 Walker A/P-loop; other site 443218006660 ATP binding site [chemical binding]; other site 443218006661 Q-loop/lid; other site 443218006662 ABC transporter signature motif; other site 443218006663 Walker B; other site 443218006664 D-loop; other site 443218006665 H-loop/switch region; other site 443218006666 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 443218006667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218006668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006669 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 443218006670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218006671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218006672 DNA binding site [nucleotide binding] 443218006673 domain linker motif; other site 443218006674 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443218006675 ligand binding site [chemical binding]; other site 443218006676 dimerization interface [polypeptide binding]; other site 443218006677 Protein of unknown function (DUF419); Region: DUF419; cl15265 443218006678 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218006679 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443218006680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218006681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218006682 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 443218006683 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218006684 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443218006685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218006686 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218006687 anti sigma factor interaction site; other site 443218006688 regulatory phosphorylation site [posttranslational modification]; other site 443218006689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218006690 active site 443218006691 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 443218006692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218006693 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443218006694 GAF domain; Region: GAF; cl15785 443218006695 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 443218006696 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 443218006697 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218006698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218006699 YCII-related domain; Region: YCII; cl00999 443218006700 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443218006701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218006702 motif II; other site 443218006703 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 443218006704 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 443218006705 dimer interface [polypeptide binding]; other site 443218006706 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 443218006707 active site 443218006708 Fe binding site [ion binding]; other site 443218006709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 443218006710 putative acyl-acceptor binding pocket; other site 443218006711 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443218006712 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 443218006713 TPP-binding site [chemical binding]; other site 443218006714 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443218006715 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443218006716 PYR/PP interface [polypeptide binding]; other site 443218006717 dimer interface [polypeptide binding]; other site 443218006718 TPP binding site [chemical binding]; other site 443218006719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218006720 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218006721 putative dimer interface [polypeptide binding]; other site 443218006722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218006723 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 443218006724 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 443218006725 potential catalytic triad [active] 443218006726 conserved cys residue [active] 443218006727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218006728 Helix-turn-helix domains; Region: HTH; cl00088 443218006729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443218006730 dimerization interface [polypeptide binding]; other site 443218006731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218006732 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218006733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006734 Helix-turn-helix domains; Region: HTH; cl00088 443218006735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006736 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006737 Isochorismatase family; Region: Isochorismatase; pfam00857 443218006738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 443218006739 catalytic triad [active] 443218006740 conserved cis-peptide bond; other site 443218006741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218006742 S-adenosylmethionine binding site [chemical binding]; other site 443218006743 Cupin domain; Region: Cupin_2; cl09118 443218006744 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 443218006745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218006746 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 443218006747 putative active site [active] 443218006748 putative metal binding site [ion binding]; other site 443218006749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218006750 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218006751 iron-sulfur cluster [ion binding]; other site 443218006752 [2Fe-2S] cluster binding site [ion binding]; other site 443218006753 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443218006754 active site 443218006755 FMN binding site [chemical binding]; other site 443218006756 substrate binding site [chemical binding]; other site 443218006757 3Fe-4S cluster binding site [ion binding]; other site 443218006758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218006761 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443218006762 active site 443218006763 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218006764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218006765 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 443218006766 FMN binding site [chemical binding]; other site 443218006767 dimer interface [polypeptide binding]; other site 443218006768 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 443218006769 BCCT family transporter; Region: BCCT; cl00569 443218006770 choline dehydrogenase; Validated; Region: PRK02106 443218006771 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218006772 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 443218006773 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218006774 tetramerization interface [polypeptide binding]; other site 443218006775 NAD(P) binding site [chemical binding]; other site 443218006776 catalytic residues [active] 443218006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 443218006778 Helix-turn-helix domains; Region: HTH; cl00088 443218006779 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 443218006780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006781 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 443218006782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006783 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218006784 PemK-like protein; Region: PemK; cl00995 443218006785 DNA polymerase IV; Validated; Region: PRK03858 443218006786 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218006787 active site 443218006788 DNA binding site [nucleotide binding] 443218006789 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218006790 Cation efflux family; Region: Cation_efflux; cl00316 443218006791 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 443218006792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218006793 ATP binding site [chemical binding]; other site 443218006794 putative Mg++ binding site [ion binding]; other site 443218006795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218006796 nucleotide binding region [chemical binding]; other site 443218006797 ATP-binding site [chemical binding]; other site 443218006798 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218006799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218006800 putative acyltransferase; Provisional; Region: PRK05790 443218006801 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218006802 dimer interface [polypeptide binding]; other site 443218006803 active site 443218006804 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 443218006805 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 443218006806 L-tyrosine decarboxylase; Provisional; Region: PRK13520 443218006807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218006808 catalytic residue [active] 443218006809 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443218006810 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 443218006811 active site 443218006812 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218006813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218006815 Helix-turn-helix domains; Region: HTH; cl00088 443218006816 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 443218006817 RNA/DNA hybrid binding site [nucleotide binding]; other site 443218006818 active site 443218006819 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 443218006820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218006821 substrate binding site [chemical binding]; other site 443218006822 oxyanion hole (OAH) forming residues; other site 443218006823 trimer interface [polypeptide binding]; other site 443218006824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218006825 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443218006826 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443218006827 minor groove reading motif; other site 443218006828 helix-hairpin-helix signature motif; other site 443218006829 active site 443218006830 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218006831 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 443218006832 phosphate binding site [ion binding]; other site 443218006833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218006834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218006835 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 443218006836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006837 dimer interface [polypeptide binding]; other site 443218006838 conserved gate region; other site 443218006839 putative PBP binding loops; other site 443218006840 ABC-ATPase subunit interface; other site 443218006841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218006843 dimer interface [polypeptide binding]; other site 443218006844 conserved gate region; other site 443218006845 putative PBP binding loops; other site 443218006846 ABC-ATPase subunit interface; other site 443218006847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218006848 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218006849 Walker A/P-loop; other site 443218006850 ATP binding site [chemical binding]; other site 443218006851 Q-loop/lid; other site 443218006852 ABC transporter signature motif; other site 443218006853 Walker B; other site 443218006854 D-loop; other site 443218006855 H-loop/switch region; other site 443218006856 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218006857 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 443218006858 ParB-like nuclease domain; Region: ParBc; cl02129 443218006859 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 443218006860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218006861 Family description; Region: UvrD_C_2; cl15862 443218006862 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218006863 homotrimer interaction site [polypeptide binding]; other site 443218006864 putative active site [active] 443218006865 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218006866 iron-sulfur cluster [ion binding]; other site 443218006867 [2Fe-2S] cluster binding site [ion binding]; other site 443218006868 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218006869 hydrophobic ligand binding site; other site 443218006870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006871 hypothetical protein; Provisional; Region: PRK07064 443218006872 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218006873 PYR/PP interface [polypeptide binding]; other site 443218006874 dimer interface [polypeptide binding]; other site 443218006875 TPP binding site [chemical binding]; other site 443218006876 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 443218006877 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443218006878 TPP-binding site [chemical binding]; other site 443218006879 short chain dehydrogenase; Provisional; Region: PRK07062 443218006880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006881 NAD(P) binding site [chemical binding]; other site 443218006882 active site 443218006883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443218006884 classical (c) SDRs; Region: SDR_c; cd05233 443218006885 NAD(P) binding site [chemical binding]; other site 443218006886 active site 443218006887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006889 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 443218006890 dimer interface [polypeptide binding]; other site 443218006891 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218006892 active site 443218006893 metal binding site [ion binding]; metal-binding site 443218006894 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 443218006895 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 443218006896 putative active site [active] 443218006897 Mn binding site [ion binding]; other site 443218006898 putative oligomer interface [polypeptide binding]; other site 443218006899 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218006900 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218006901 FMN-binding pocket [chemical binding]; other site 443218006902 flavin binding motif; other site 443218006903 phosphate binding motif [ion binding]; other site 443218006904 beta-alpha-beta structure motif; other site 443218006905 NAD binding pocket [chemical binding]; other site 443218006906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218006907 catalytic loop [active] 443218006908 iron binding site [ion binding]; other site 443218006909 Cupin domain; Region: Cupin_2; cl09118 443218006910 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218006911 homotrimer interaction site [polypeptide binding]; other site 443218006912 putative active site [active] 443218006913 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218006914 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 443218006915 NAD(P) binding site [chemical binding]; other site 443218006916 catalytic residues [active] 443218006917 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218006918 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 443218006919 Walker A/P-loop; other site 443218006920 ATP binding site [chemical binding]; other site 443218006921 Q-loop/lid; other site 443218006922 ABC transporter signature motif; other site 443218006923 Walker B; other site 443218006924 D-loop; other site 443218006925 H-loop/switch region; other site 443218006926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218006927 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218006928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218006929 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 443218006930 NMT1-like family; Region: NMT1_2; cl15260 443218006931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218006932 Helix-turn-helix domains; Region: HTH; cl00088 443218006933 YCII-related domain; Region: YCII; cl00999 443218006934 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218006935 Uncharacterized conserved protein [Function unknown]; Region: COG2128 443218006936 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218006937 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218006938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218006939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218006940 DNA binding residues [nucleotide binding] 443218006941 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443218006942 Sulfatase; Region: Sulfatase; cl10460 443218006943 heat shock protein 90; Provisional; Region: PRK05218 443218006944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218006945 ATP binding site [chemical binding]; other site 443218006946 Mg2+ binding site [ion binding]; other site 443218006947 G-X-G motif; other site 443218006948 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 443218006949 active site 443218006950 homotetramer interface [polypeptide binding]; other site 443218006951 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218006952 CoenzymeA binding site [chemical binding]; other site 443218006953 subunit interaction site [polypeptide binding]; other site 443218006954 PHB binding site; other site 443218006955 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 443218006956 putative hydrophobic ligand binding site [chemical binding]; other site 443218006957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218006958 dimerization interface [polypeptide binding]; other site 443218006959 putative DNA binding site [nucleotide binding]; other site 443218006960 putative Zn2+ binding site [ion binding]; other site 443218006961 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 443218006962 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006964 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218006965 FAD binding domain; Region: FAD_binding_4; pfam01565 443218006966 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 443218006967 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 443218006968 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218006969 Amidase; Region: Amidase; cl11426 443218006970 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443218006971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218006972 Ligand Binding Site [chemical binding]; other site 443218006973 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443218006974 LemA family; Region: LemA; cl00742 443218006975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218006976 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218006977 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 443218006978 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 443218006979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218006980 DNA-binding site [nucleotide binding]; DNA binding site 443218006981 FCD domain; Region: FCD; cl11656 443218006982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218006983 RNA binding surface [nucleotide binding]; other site 443218006984 Secretory lipase; Region: LIP; pfam03583 443218006985 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 443218006986 intracellular protease, PfpI family; Region: PfpI; TIGR01382 443218006987 proposed catalytic triad [active] 443218006988 conserved cys residue [active] 443218006989 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 443218006990 Uncharacterized conserved protein [Function unknown]; Region: COG2411 443218006991 hypothetical protein; Provisional; Region: PRK06753 443218006992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218006993 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218006994 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218006995 DNA binding residues [nucleotide binding] 443218006996 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 443218006997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218006998 S-adenosylmethionine binding site [chemical binding]; other site 443218006999 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443218007000 iron-sulfur cluster [ion binding]; other site 443218007001 [2Fe-2S] cluster binding site [ion binding]; other site 443218007002 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218007003 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 443218007004 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443218007005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007007 DNA binding residues [nucleotide binding] 443218007008 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 443218007009 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 443218007010 putative dimer interface [polypeptide binding]; other site 443218007011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007013 Helix-turn-helix domains; Region: HTH; cl00088 443218007014 FtsI repressor; Provisional; Region: PRK10883 443218007015 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007016 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007017 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007018 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443218007019 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443218007020 putative substrate binding site [chemical binding]; other site 443218007021 putative ATP binding site [chemical binding]; other site 443218007022 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218007023 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443218007024 Transglycosylase; Region: Transgly; cl07896 443218007025 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218007026 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 443218007027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007028 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218007029 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218007030 Helix-turn-helix domains; Region: HTH; cl00088 443218007031 WYL domain; Region: WYL; cl14852 443218007032 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443218007033 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 443218007034 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 443218007035 putative active site [active] 443218007036 putative metal binding site [ion binding]; other site 443218007037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007038 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 443218007039 active site 443218007040 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218007041 active site 1 [active] 443218007042 active site 2 [active] 443218007043 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218007044 nudix motif; other site 443218007045 acyl-CoA synthetase; Validated; Region: PRK07788 443218007046 AMP-binding enzyme; Region: AMP-binding; cl15778 443218007047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218007048 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 443218007049 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218007050 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218007051 TIGR03086 family protein; Region: TIGR03086 443218007052 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 443218007053 FAD binding domain; Region: FAD_binding_4; pfam01565 443218007054 Berberine and berberine like; Region: BBE; pfam08031 443218007055 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007056 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007057 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218007058 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 443218007059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 443218007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 443218007061 NRDE protein; Region: NRDE; cl01315 443218007062 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218007063 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218007064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007065 active site 443218007066 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218007067 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443218007068 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443218007069 trimer interface [polypeptide binding]; other site 443218007070 putative metal binding site [ion binding]; other site 443218007071 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 443218007072 putative catalytic residue [active] 443218007073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218007074 Helix-turn-helix domains; Region: HTH; cl00088 443218007075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218007076 dimerization interface [polypeptide binding]; other site 443218007077 enoyl-CoA hydratase; Provisional; Region: PRK05862 443218007078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007079 substrate binding site [chemical binding]; other site 443218007080 oxyanion hole (OAH) forming residues; other site 443218007081 trimer interface [polypeptide binding]; other site 443218007082 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007083 NAD(P) binding site [chemical binding]; other site 443218007084 catalytic residues [active] 443218007085 short chain dehydrogenase; Provisional; Region: PRK07825 443218007086 classical (c) SDRs; Region: SDR_c; cd05233 443218007087 NAD(P) binding site [chemical binding]; other site 443218007088 active site 443218007089 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218007090 Helix-turn-helix domains; Region: HTH; cl00088 443218007091 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218007092 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218007093 FAD binding pocket [chemical binding]; other site 443218007094 FAD binding motif [chemical binding]; other site 443218007095 phosphate binding motif [ion binding]; other site 443218007096 beta-alpha-beta structure motif; other site 443218007097 NAD binding pocket [chemical binding]; other site 443218007098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007099 catalytic loop [active] 443218007100 iron binding site [ion binding]; other site 443218007101 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218007102 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 443218007103 putative di-iron ligands [ion binding]; other site 443218007104 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218007105 Conserved membrane protein YqhR; Region: YqhR; pfam11085 443218007106 H+ Antiporter protein; Region: 2A0121; TIGR00900 443218007107 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 443218007108 putative FMN binding site [chemical binding]; other site 443218007109 NADPH bind site [chemical binding]; other site 443218007110 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218007111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007112 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443218007113 substrate binding site [chemical binding]; other site 443218007114 oxyanion hole (OAH) forming residues; other site 443218007115 trimer interface [polypeptide binding]; other site 443218007116 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218007117 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218007118 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443218007119 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 443218007120 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 443218007121 active site 443218007122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007123 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218007124 NAD(P) binding site [chemical binding]; other site 443218007125 active site 443218007126 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007127 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218007128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007129 NAD(P) binding site [chemical binding]; other site 443218007130 active site 443218007131 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007132 hydrophobic ligand binding site; other site 443218007133 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218007134 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 443218007135 Walker A/P-loop; other site 443218007136 ATP binding site [chemical binding]; other site 443218007137 Q-loop/lid; other site 443218007138 ABC transporter signature motif; other site 443218007139 Walker B; other site 443218007140 D-loop; other site 443218007141 H-loop/switch region; other site 443218007142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218007143 non-specific DNA binding site [nucleotide binding]; other site 443218007144 salt bridge; other site 443218007145 sequence-specific DNA binding site [nucleotide binding]; other site 443218007146 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443218007147 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 443218007148 Walker A/P-loop; other site 443218007149 ATP binding site [chemical binding]; other site 443218007150 Q-loop/lid; other site 443218007151 ABC transporter signature motif; other site 443218007152 Walker B; other site 443218007153 D-loop; other site 443218007154 H-loop/switch region; other site 443218007155 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 443218007156 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 443218007157 Walker A/P-loop; other site 443218007158 ATP binding site [chemical binding]; other site 443218007159 Q-loop/lid; other site 443218007160 ABC transporter signature motif; other site 443218007161 Walker B; other site 443218007162 D-loop; other site 443218007163 H-loop/switch region; other site 443218007164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443218007165 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443218007166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007167 dimer interface [polypeptide binding]; other site 443218007168 conserved gate region; other site 443218007169 putative PBP binding loops; other site 443218007170 ABC-ATPase subunit interface; other site 443218007171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443218007172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218007173 dimer interface [polypeptide binding]; other site 443218007174 conserved gate region; other site 443218007175 putative PBP binding loops; other site 443218007176 ABC-ATPase subunit interface; other site 443218007177 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 443218007178 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443218007179 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 443218007180 putative substrate binding site [chemical binding]; other site 443218007181 putative ATP binding site [chemical binding]; other site 443218007182 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 443218007183 DNA-binding site [nucleotide binding]; DNA binding site 443218007184 RNA-binding motif; other site 443218007185 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218007186 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218007187 active site 2 [active] 443218007188 active site 1 [active] 443218007189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007190 Helix-turn-helix domains; Region: HTH; cl00088 443218007191 WHG domain; Region: WHG; pfam13305 443218007192 potassium/proton antiporter; Reviewed; Region: PRK05326 443218007193 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218007194 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218007195 AMP-binding enzyme; Region: AMP-binding; cl15778 443218007196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007197 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007198 active site 443218007199 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218007200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218007201 DNA-binding site [nucleotide binding]; DNA binding site 443218007202 FCD domain; Region: FCD; cl11656 443218007203 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218007204 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443218007205 putative [Fe4-S4] binding site [ion binding]; other site 443218007206 putative molybdopterin cofactor binding site [chemical binding]; other site 443218007207 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218007208 putative molybdopterin cofactor binding site; other site 443218007209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007210 Helix-turn-helix domains; Region: HTH; cl00088 443218007211 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443218007212 enoyl-CoA hydratase; Provisional; Region: PRK06688 443218007213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007214 substrate binding site [chemical binding]; other site 443218007215 oxyanion hole (OAH) forming residues; other site 443218007216 trimer interface [polypeptide binding]; other site 443218007217 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 443218007218 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218007219 FMN binding site [chemical binding]; other site 443218007220 substrate binding site [chemical binding]; other site 443218007221 putative catalytic residue [active] 443218007222 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 443218007223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007224 substrate binding site [chemical binding]; other site 443218007225 oxyanion hole (OAH) forming residues; other site 443218007226 trimer interface [polypeptide binding]; other site 443218007227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007228 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218007229 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 443218007230 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218007231 dimer interface [polypeptide binding]; other site 443218007232 active site 443218007233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007234 Helix-turn-helix domains; Region: HTH; cl00088 443218007235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007236 Helix-turn-helix domains; Region: HTH; cl00088 443218007237 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 443218007238 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 443218007239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007240 AlkA N-terminal domain; Region: AlkA_N; cl05528 443218007241 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443218007242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443218007243 minor groove reading motif; other site 443218007244 helix-hairpin-helix signature motif; other site 443218007245 substrate binding pocket [chemical binding]; other site 443218007246 active site 443218007247 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443218007248 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218007249 DNA binding site [nucleotide binding] 443218007250 active site 443218007251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218007252 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 443218007253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007254 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 443218007255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007257 active site 443218007258 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443218007259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218007260 tetrameric interface [polypeptide binding]; other site 443218007261 NAD binding site [chemical binding]; other site 443218007262 catalytic residues [active] 443218007263 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218007264 Helix-turn-helix domains; Region: HTH; cl00088 443218007265 Secretory lipase; Region: LIP; pfam03583 443218007266 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 443218007267 Strictosidine synthase; Region: Str_synth; pfam03088 443218007268 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 443218007269 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 443218007270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007271 S-adenosylmethionine binding site [chemical binding]; other site 443218007272 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 443218007273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007274 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443218007275 active site 443218007276 metal binding site [ion binding]; metal-binding site 443218007277 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218007278 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218007279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218007280 Transporter associated domain; Region: CorC_HlyC; cl08393 443218007281 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218007282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218007283 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 443218007284 active site 443218007285 Integral membrane protein DUF95; Region: DUF95; cl00572 443218007286 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443218007287 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218007288 MoxR-like ATPases [General function prediction only]; Region: COG0714 443218007289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218007290 Walker A motif; other site 443218007291 ATP binding site [chemical binding]; other site 443218007292 Walker B motif; other site 443218007293 arginine finger; other site 443218007294 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443218007295 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 443218007296 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 443218007297 RDD family; Region: RDD; cl00746 443218007298 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 443218007299 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 443218007300 VanW like protein; Region: VanW; pfam04294 443218007301 DNA polymerase IV; Provisional; Region: PRK03348 443218007302 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218007303 active site 443218007304 DNA binding site [nucleotide binding] 443218007305 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 443218007306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218007307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218007308 catalytic residue [active] 443218007309 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007310 hydrophobic ligand binding site; other site 443218007311 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443218007312 RDD family; Region: RDD; cl00746 443218007313 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218007314 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007315 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007316 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 443218007317 putative active site [active] 443218007318 metal binding site [ion binding]; metal-binding site 443218007319 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443218007320 putative catalytic site [active] 443218007321 putative metal binding site [ion binding]; other site 443218007322 putative phosphate binding site [ion binding]; other site 443218007323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 443218007324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007325 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218007326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007327 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 443218007328 Septum formation; Region: Septum_form; pfam13845 443218007329 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 443218007330 putative active site [active] 443218007331 putative CoA binding site [chemical binding]; other site 443218007332 nudix motif; other site 443218007333 metal binding site [ion binding]; metal-binding site 443218007334 choline dehydrogenase; Validated; Region: PRK02106 443218007335 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218007336 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007337 NAD(P) binding site [chemical binding]; other site 443218007338 catalytic residues [active] 443218007339 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 443218007340 A new structural DNA glycosylase; Region: AlkD_like; cd06561 443218007341 active site 443218007342 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218007343 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 443218007344 Walker A/P-loop; other site 443218007345 ATP binding site [chemical binding]; other site 443218007346 Q-loop/lid; other site 443218007347 ABC transporter signature motif; other site 443218007348 Walker B; other site 443218007349 D-loop; other site 443218007350 H-loop/switch region; other site 443218007351 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443218007352 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218007353 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 443218007354 putative NAD(P) binding site [chemical binding]; other site 443218007355 Helix-turn-helix domains; Region: HTH; cl00088 443218007356 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007357 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218007358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007359 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 443218007360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007362 DNA binding residues [nucleotide binding] 443218007363 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218007364 putative acyl-acceptor binding pocket; other site 443218007365 Amino acid permease; Region: AA_permease_2; pfam13520 443218007366 Spore germination protein; Region: Spore_permease; cl15802 443218007367 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443218007368 Helix-turn-helix domains; Region: HTH; cl00088 443218007369 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218007370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007371 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218007372 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218007373 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 443218007374 tetrameric interface [polypeptide binding]; other site 443218007375 NAD binding site [chemical binding]; other site 443218007376 catalytic residues [active] 443218007377 substrate binding site [chemical binding]; other site 443218007378 DsrE/DsrF-like family; Region: DrsE; cl00672 443218007379 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007380 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007381 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443218007382 glycosyltransferase, MGT family; Region: MGT; TIGR01426 443218007383 active site 443218007384 TDP-binding site; other site 443218007385 acceptor substrate-binding pocket; other site 443218007386 homodimer interface [polypeptide binding]; other site 443218007387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218007388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218007390 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218007391 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218007392 active site 443218007393 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218007394 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 443218007395 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 443218007396 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218007397 phosphate binding site [ion binding]; other site 443218007398 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 443218007399 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218007400 phosphate binding site [ion binding]; other site 443218007401 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 443218007402 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218007403 active site 443218007404 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218007405 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218007406 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 443218007407 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 443218007408 putative NADP binding site [chemical binding]; other site 443218007409 active site 443218007410 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 443218007411 Helix-turn-helix domains; Region: HTH; cl00088 443218007412 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443218007413 putative hydrophobic ligand binding site [chemical binding]; other site 443218007414 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007415 hydrophobic ligand binding site; other site 443218007416 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007417 DNA binding residues [nucleotide binding] 443218007418 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218007419 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218007420 DNA binding residues [nucleotide binding] 443218007421 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218007422 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218007423 FAD binding pocket [chemical binding]; other site 443218007424 FAD binding motif [chemical binding]; other site 443218007425 phosphate binding motif [ion binding]; other site 443218007426 NAD binding pocket [chemical binding]; other site 443218007427 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 443218007428 CoA-transferase family III; Region: CoA_transf_3; pfam02515 443218007429 aldehyde dehydrogenase; Provisional; Region: PRK11903 443218007430 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007431 NAD(P) binding site [chemical binding]; other site 443218007432 catalytic residues [active] 443218007433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007435 active site 443218007436 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443218007437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218007438 inhibitor-cofactor binding pocket; inhibition site 443218007439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218007440 catalytic residue [active] 443218007441 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218007442 amino acid transporter; Region: 2A0306; TIGR00909 443218007443 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 443218007444 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218007445 Helix-turn-helix domains; Region: HTH; cl00088 443218007446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007447 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 443218007448 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 443218007449 active site 443218007450 DNA binding site [nucleotide binding] 443218007451 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 443218007452 DNA binding site [nucleotide binding] 443218007453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007455 S-adenosylmethionine binding site [chemical binding]; other site 443218007456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218007457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218007458 ATP binding site [chemical binding]; other site 443218007459 Mg2+ binding site [ion binding]; other site 443218007460 G-X-G motif; other site 443218007461 Predicted membrane protein [Function unknown]; Region: COG4270 443218007462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443218007464 active site 443218007465 metal binding site [ion binding]; metal-binding site 443218007466 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 443218007467 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218007468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007469 NAD(P) binding pocket [chemical binding]; other site 443218007470 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443218007471 Helix-turn-helix domains; Region: HTH; cl00088 443218007472 Helix-turn-helix domains; Region: HTH; cl00088 443218007473 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 443218007474 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 443218007475 dimer interface [polypeptide binding]; other site 443218007476 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 443218007477 active site 443218007478 Fe binding site [ion binding]; other site 443218007479 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 443218007480 O-methyltransferase; Region: Methyltransf_2; pfam00891 443218007481 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218007482 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218007483 fumarylacetoacetase; Region: PLN02856 443218007484 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 443218007485 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218007486 Cupin domain; Region: Cupin_2; cl09118 443218007487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218007488 Helix-turn-helix domains; Region: HTH; cl00088 443218007489 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 443218007490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007492 metabolite-proton symporter; Region: 2A0106; TIGR00883 443218007493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007494 putative substrate translocation pore; other site 443218007495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443218007496 Helix-turn-helix domains; Region: HTH; cl00088 443218007497 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 443218007498 putative substrate binding pocket [chemical binding]; other site 443218007499 dimerization interface [polypeptide binding]; other site 443218007500 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 443218007501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218007502 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218007503 CAAX protease self-immunity; Region: Abi; cl00558 443218007504 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218007505 Helix-turn-helix domains; Region: HTH; cl00088 443218007506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218007508 putative substrate translocation pore; other site 443218007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007510 endonuclease IV; Provisional; Region: PRK01060 443218007511 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443218007512 AP (apurinic/apyrimidinic) site pocket; other site 443218007513 DNA interaction; other site 443218007514 Metal-binding active site; metal-binding site 443218007515 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007516 NAD(P) binding site [chemical binding]; other site 443218007517 catalytic residues [active] 443218007518 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 443218007519 Helix-turn-helix domains; Region: HTH; cl00088 443218007520 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 443218007521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218007522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218007523 catalytic residue [active] 443218007524 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 443218007525 Sodium:solute symporter family; Region: SSF; cl00456 443218007526 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218007527 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218007528 biotin carboxylase-like protein; Validated; Region: PRK06524 443218007529 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218007530 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 443218007531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007532 putative substrate translocation pore; other site 443218007533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218007535 dimerization interface [polypeptide binding]; other site 443218007536 putative DNA binding site [nucleotide binding]; other site 443218007537 putative Zn2+ binding site [ion binding]; other site 443218007538 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218007539 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218007540 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443218007541 ATP binding site [chemical binding]; other site 443218007542 substrate binding site [chemical binding]; other site 443218007543 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 443218007544 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 443218007545 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 443218007546 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 443218007547 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443218007548 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218007549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218007550 motif II; other site 443218007551 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218007552 Helix-turn-helix domains; Region: HTH; cl00088 443218007553 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218007554 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 443218007555 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 443218007556 active site 443218007557 catalytic triad [active] 443218007558 oxyanion hole [active] 443218007559 Protein of unknown function DUF72; Region: DUF72; cl00777 443218007560 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443218007561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218007562 DNA binding residues [nucleotide binding] 443218007563 dimerization interface [polypeptide binding]; other site 443218007564 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218007565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007566 Domain of unknown function (DUF427); Region: DUF427; cl00998 443218007567 Domain of unknown function (DUF427); Region: DUF427; cl00998 443218007568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007569 Helix-turn-helix domains; Region: HTH; cl00088 443218007570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218007571 catalytic loop [active] 443218007572 iron binding site [ion binding]; other site 443218007573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218007574 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218007575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007577 putative substrate translocation pore; other site 443218007578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 443218007579 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 443218007580 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 443218007581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218007582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218007583 DNA binding residues [nucleotide binding] 443218007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007585 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 443218007586 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443218007587 AAA domain; Region: AAA_27; pfam13514 443218007588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007589 ABC transporter signature motif; other site 443218007590 Walker B; other site 443218007591 D-loop; other site 443218007592 H-loop/switch region; other site 443218007593 Protein of unknown function DUF262; Region: DUF262; cl14890 443218007594 Protein of unknown function DUF262; Region: DUF262; cl14890 443218007595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218007596 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 443218007597 Walker A motif; other site 443218007598 ATP binding site [chemical binding]; other site 443218007599 Walker B motif; other site 443218007600 Uncharacterized conserved protein [Function unknown]; Region: COG3410 443218007601 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 443218007602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218007603 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 443218007604 putative homodimer interface [polypeptide binding]; other site 443218007605 putative active site [active] 443218007606 catalytic site [active] 443218007607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218007608 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443218007609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218007610 ATP binding site [chemical binding]; other site 443218007611 putative Mg++ binding site [ion binding]; other site 443218007612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218007613 nucleotide binding region [chemical binding]; other site 443218007614 ATP-binding site [chemical binding]; other site 443218007615 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 443218007616 Active Sites [active] 443218007617 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 443218007618 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218007619 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 443218007620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218007621 catalytic residue [active] 443218007622 Protein of unknown function DUF262; Region: DUF262; cl14890 443218007623 Protein of unknown function DUF262; Region: DUF262; cl14890 443218007624 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 443218007625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007626 S-adenosylmethionine binding site [chemical binding]; other site 443218007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 443218007628 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218007629 DNA binding residues [nucleotide binding] 443218007630 dimerization interface [polypeptide binding]; other site 443218007631 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218007632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218007633 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218007634 TIGR03086 family protein; Region: TIGR03086 443218007635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007636 Helix-turn-helix domains; Region: HTH; cl00088 443218007637 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218007638 Uncharacterized conserved protein [Function unknown]; Region: COG4997 443218007639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218007640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 443218007641 active site 443218007642 phosphorylation site [posttranslational modification] 443218007643 intermolecular recognition site; other site 443218007644 dimerization interface [polypeptide binding]; other site 443218007645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218007646 DNA binding residues [nucleotide binding] 443218007647 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443218007648 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 443218007649 PQQ-like domain; Region: PQQ_2; pfam13360 443218007650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218007651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218007652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218007653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218007654 DNA binding residues [nucleotide binding] 443218007655 Helix-turn-helix domains; Region: HTH; cl00088 443218007656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218007657 non-specific DNA binding site [nucleotide binding]; other site 443218007658 salt bridge; other site 443218007659 sequence-specific DNA binding site [nucleotide binding]; other site 443218007660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007661 Walker A/P-loop; other site 443218007662 ATP binding site [chemical binding]; other site 443218007663 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 443218007664 structural tetrad; other site 443218007665 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 443218007666 structural tetrad; other site 443218007667 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 443218007668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007669 Helix-turn-helix domains; Region: HTH; cl00088 443218007670 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 443218007671 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 443218007672 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 443218007673 putative active site [active] 443218007674 putative metal binding site [ion binding]; other site 443218007675 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443218007676 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218007677 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 443218007678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007679 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218007680 AMP-binding enzyme; Region: AMP-binding; cl15778 443218007681 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218007682 putative acyl-acceptor binding pocket; other site 443218007683 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218007684 Ferredoxin [Energy production and conversion]; Region: COG1146 443218007685 4Fe-4S binding domain; Region: Fer4; cl02805 443218007686 ferredoxin-NADP+ reductase; Region: PLN02852 443218007687 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443218007688 Helix-turn-helix domains; Region: HTH; cl00088 443218007689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218007690 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 443218007691 Walker A/P-loop; other site 443218007692 ATP binding site [chemical binding]; other site 443218007693 Q-loop/lid; other site 443218007694 ABC transporter signature motif; other site 443218007695 Walker B; other site 443218007696 D-loop; other site 443218007697 H-loop/switch region; other site 443218007698 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218007699 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218007700 putative active site [active] 443218007701 Helix-turn-helix domains; Region: HTH; cl00088 443218007702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007703 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 443218007704 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218007705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218007706 active site 443218007707 metal binding site [ion binding]; metal-binding site 443218007708 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218007709 nudix motif; other site 443218007710 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 443218007711 Helix-turn-helix domains; Region: HTH; cl00088 443218007712 Cupin domain; Region: Cupin_2; cl09118 443218007713 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218007714 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218007715 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 443218007716 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443218007717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007718 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218007719 catalytic core [active] 443218007720 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218007721 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 443218007722 N- and C-terminal domain interface [polypeptide binding]; other site 443218007723 active site 443218007724 MgATP binding site [chemical binding]; other site 443218007725 catalytic site [active] 443218007726 metal binding site [ion binding]; metal-binding site 443218007727 carbohydrate binding site [chemical binding]; other site 443218007728 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218007729 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 443218007730 putative N- and C-terminal domain interface [polypeptide binding]; other site 443218007731 putative active site [active] 443218007732 putative MgATP binding site [chemical binding]; other site 443218007733 catalytic site [active] 443218007734 metal binding site [ion binding]; metal-binding site 443218007735 putative xylulose binding site [chemical binding]; other site 443218007736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218007737 polyol permease family; Region: 2A0118; TIGR00897 443218007738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007739 putative substrate translocation pore; other site 443218007740 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443218007741 Helix-turn-helix domains; Region: HTH; cl00088 443218007742 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 443218007743 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218007744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007745 Helix-turn-helix domains; Region: HTH; cl00088 443218007746 short chain dehydrogenase; Provisional; Region: PRK06197 443218007747 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443218007748 putative NAD(P) binding site [chemical binding]; other site 443218007749 active site 443218007750 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 443218007751 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 443218007752 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218007753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218007754 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 443218007755 S-adenosylmethionine binding site [chemical binding]; other site 443218007756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218007757 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443218007758 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443218007759 dimer interface [polypeptide binding]; other site 443218007760 active site 443218007761 CoA binding pocket [chemical binding]; other site 443218007762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218007763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218007765 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443218007766 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443218007767 dimer interface [polypeptide binding]; other site 443218007768 active site 443218007769 CoA binding pocket [chemical binding]; other site 443218007770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218007771 Helix-turn-helix domains; Region: HTH; cl00088 443218007772 Protease prsW family; Region: PrsW-protease; cl15823 443218007773 Bacterial PH domain; Region: DUF304; cl01348 443218007774 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443218007775 phospholipase D alpha; Region: PLN02270 443218007776 putative active site [active] 443218007777 catalytic site [active] 443218007778 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 443218007779 putative active site [active] 443218007780 catalytic site [active] 443218007781 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 443218007782 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 443218007783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218007784 non-specific DNA binding site [nucleotide binding]; other site 443218007785 salt bridge; other site 443218007786 sequence-specific DNA binding site [nucleotide binding]; other site 443218007787 Cupin domain; Region: Cupin_2; cl09118 443218007788 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 443218007789 nucleotide binding site [chemical binding]; other site 443218007790 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443218007791 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443218007792 active site 443218007793 DNA binding site [nucleotide binding] 443218007794 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443218007795 DNA binding site [nucleotide binding] 443218007796 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218007797 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007798 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007799 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218007800 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218007801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007802 putative substrate translocation pore; other site 443218007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007805 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218007806 hypothetical protein; Provisional; Region: PRK06849 443218007807 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218007808 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443218007809 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 443218007810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443218007811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218007812 GatB domain; Region: GatB_Yqey; cl11497 443218007813 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218007814 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 443218007815 Domain of unknown function (DUF305); Region: DUF305; cl15795 443218007816 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218007817 Cytochrome P450; Region: p450; pfam00067 443218007818 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443218007819 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218007820 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218007821 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218007822 protein binding site [polypeptide binding]; other site 443218007823 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 443218007824 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218007825 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443218007826 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 443218007827 putative NAD(P) binding site [chemical binding]; other site 443218007828 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 443218007829 Fe-S cluster binding site [ion binding]; other site 443218007830 DNA binding site [nucleotide binding] 443218007831 active site 443218007832 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 443218007833 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218007834 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 443218007835 NAD binding site [chemical binding]; other site 443218007836 Phe binding site; other site 443218007837 O-methyltransferase; Region: Methyltransf_2; pfam00891 443218007838 benzoate transport; Region: 2A0115; TIGR00895 443218007839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007840 putative substrate translocation pore; other site 443218007841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218007842 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218007843 Protein of unknown function (DUF952); Region: DUF952; cl01393 443218007844 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218007845 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443218007846 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218007847 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 443218007848 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 443218007849 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 443218007850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218007851 dimerization interface [polypeptide binding]; other site 443218007852 putative DNA binding site [nucleotide binding]; other site 443218007853 putative Zn2+ binding site [ion binding]; other site 443218007854 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218007855 hydrophobic ligand binding site; other site 443218007856 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218007857 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218007858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007860 active site 443218007861 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 443218007862 active site 443218007863 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 443218007864 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443218007865 BCCT family transporter; Region: BCCT; cl00569 443218007866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007868 active site 443218007869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218007870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218007871 active site 443218007872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007873 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443218007874 putative active site [active] 443218007875 putative catalytic site [active] 443218007876 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 443218007877 Iron-sulfur protein interface; other site 443218007878 proximal heme binding site [chemical binding]; other site 443218007879 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 443218007880 Iron-sulfur protein interface; other site 443218007881 proximal heme binding site [chemical binding]; other site 443218007882 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 443218007883 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 443218007884 4Fe-4S binding domain; Region: Fer4; cl02805 443218007885 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 443218007886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007887 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218007888 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 443218007889 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 443218007890 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 443218007891 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218007892 active site 443218007893 ATP binding site [chemical binding]; other site 443218007894 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 443218007895 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007896 Family description; Region: UvrD_C_2; cl15862 443218007897 amino acid transporter; Region: 2A0306; TIGR00909 443218007898 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 443218007899 iron-sulfur cluster [ion binding]; other site 443218007900 [2Fe-2S] cluster binding site [ion binding]; other site 443218007901 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 443218007902 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443218007903 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218007904 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 443218007905 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 443218007906 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 443218007907 ethanolamine permease; Region: 2A0305; TIGR00908 443218007908 Spore germination protein; Region: Spore_permease; cl15802 443218007909 enoyl-CoA hydratase; Provisional; Region: PRK06142 443218007910 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218007911 substrate binding site [chemical binding]; other site 443218007912 oxyanion hole (OAH) forming residues; other site 443218007913 trimer interface [polypeptide binding]; other site 443218007914 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 443218007915 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218007916 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 443218007917 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443218007918 EspG family; Region: ESX-1_EspG; pfam14011 443218007919 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218007920 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 443218007921 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218007922 DinB superfamily; Region: DinB_2; pfam12867 443218007923 Domain of unknown function (DUF202); Region: DUF202; cl09954 443218007924 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 443218007925 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 443218007926 diiron binding motif [ion binding]; other site 443218007927 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 443218007928 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443218007929 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443218007930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007931 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 443218007932 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 443218007933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007934 NAD(P) binding site [chemical binding]; other site 443218007935 active site 443218007936 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218007937 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218007938 catalytic residues [active] 443218007939 catalytic nucleophile [active] 443218007940 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218007941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443218007942 Probable transposase; Region: OrfB_IS605; pfam01385 443218007943 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218007944 MOSC domain; Region: MOSC; pfam03473 443218007945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218007946 Cytochrome P450; Region: p450; pfam00067 443218007947 Helix-turn-helix domains; Region: HTH; cl00088 443218007948 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 443218007949 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443218007950 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443218007951 active site 443218007952 catalytic site [active] 443218007953 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 443218007954 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 443218007955 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218007956 putative NAD(P) binding site [chemical binding]; other site 443218007957 putative active site [active] 443218007958 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 443218007959 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218007960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007961 Walker A/P-loop; other site 443218007962 ATP binding site [chemical binding]; other site 443218007963 Q-loop/lid; other site 443218007964 ABC transporter signature motif; other site 443218007965 Walker B; other site 443218007966 D-loop; other site 443218007967 H-loop/switch region; other site 443218007968 ABC transporter; Region: ABC_tran_2; pfam12848 443218007969 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218007970 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218007971 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 443218007972 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 443218007973 Walker A/P-loop; other site 443218007974 ATP binding site [chemical binding]; other site 443218007975 Q-loop/lid; other site 443218007976 ABC transporter signature motif; other site 443218007977 Walker B; other site 443218007978 D-loop; other site 443218007979 H-loop/switch region; other site 443218007980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218007981 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218007982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218007983 Walker A/P-loop; other site 443218007984 ATP binding site [chemical binding]; other site 443218007985 Q-loop/lid; other site 443218007986 ABC transporter signature motif; other site 443218007987 Walker B; other site 443218007988 D-loop; other site 443218007989 H-loop/switch region; other site 443218007990 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443218007991 Aspartase; Region: Aspartase; cd01357 443218007992 active sites [active] 443218007993 tetramer interface [polypeptide binding]; other site 443218007994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218007995 tartrate dehydrogenase; Provisional; Region: PRK08194 443218007996 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 443218007997 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218007998 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443218007999 NAD(P) binding site [chemical binding]; other site 443218008000 catalytic residues [active] 443218008001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008002 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 443218008003 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 443218008004 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218008005 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218008006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218008007 substrate binding pocket [chemical binding]; other site 443218008008 membrane-bound complex binding site; other site 443218008009 hinge residues; other site 443218008010 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443218008011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218008012 dimer interface [polypeptide binding]; other site 443218008013 conserved gate region; other site 443218008014 putative PBP binding loops; other site 443218008015 ABC-ATPase subunit interface; other site 443218008016 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218008017 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 443218008018 Walker A/P-loop; other site 443218008019 ATP binding site [chemical binding]; other site 443218008020 Q-loop/lid; other site 443218008021 ABC transporter signature motif; other site 443218008022 Walker B; other site 443218008023 D-loop; other site 443218008024 H-loop/switch region; other site 443218008025 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 443218008026 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 443218008027 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218008028 inhibitor-cofactor binding pocket; inhibition site 443218008029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008030 catalytic residue [active] 443218008031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218008032 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218008033 tetramerization interface [polypeptide binding]; other site 443218008034 NAD(P) binding site [chemical binding]; other site 443218008035 catalytic residues [active] 443218008036 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218008037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008038 DNA-binding site [nucleotide binding]; DNA binding site 443218008039 FCD domain; Region: FCD; cl11656 443218008040 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 443218008041 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 443218008042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008043 DNA-binding site [nucleotide binding]; DNA binding site 443218008044 FCD domain; Region: FCD; cl11656 443218008045 Cupin domain; Region: Cupin_2; cl09118 443218008046 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218008047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218008048 DNA-binding site [nucleotide binding]; DNA binding site 443218008049 FCD domain; Region: FCD; cl11656 443218008050 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443218008051 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218008052 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218008053 catalytic residue [active] 443218008054 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218008055 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443218008056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008057 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218008058 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218008059 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 443218008060 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218008061 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218008062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008063 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 443218008064 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 443218008065 CGNR zinc finger; Region: zf-CGNR; pfam11706 443218008066 Predicted transcriptional regulator [Transcription]; Region: COG2378 443218008067 Helix-turn-helix domains; Region: HTH; cl00088 443218008068 WYL domain; Region: WYL; cl14852 443218008069 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443218008070 homotrimer interaction site [polypeptide binding]; other site 443218008071 putative active site [active] 443218008072 Protein of unknown function, DUF488; Region: DUF488; cl01246 443218008073 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218008074 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 443218008075 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 443218008076 AMP-binding enzyme; Region: AMP-binding; cl15778 443218008077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218008078 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443218008079 Short C-terminal domain; Region: SHOCT; cl01373 443218008080 Glutaminase; Region: Glutaminase; cl00907 443218008081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218008082 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218008083 Walker A/P-loop; other site 443218008084 ATP binding site [chemical binding]; other site 443218008085 Q-loop/lid; other site 443218008086 ABC transporter signature motif; other site 443218008087 Walker B; other site 443218008088 D-loop; other site 443218008089 H-loop/switch region; other site 443218008090 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443218008091 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218008092 Pirin-related protein [General function prediction only]; Region: COG1741 443218008093 Cupin domain; Region: Cupin_2; cl09118 443218008094 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 443218008095 Pirin-related protein [General function prediction only]; Region: COG1741 443218008096 Cupin domain; Region: Cupin_2; cl09118 443218008097 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218008098 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443218008099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218008100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008101 homodimer interface [polypeptide binding]; other site 443218008102 catalytic residue [active] 443218008103 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 443218008104 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 443218008105 [4Fe-4S] binding site [ion binding]; other site 443218008106 molybdopterin cofactor binding site; other site 443218008107 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 443218008108 molybdopterin cofactor binding site; other site 443218008109 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 443218008110 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218008111 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 443218008112 FAD binding pocket [chemical binding]; other site 443218008113 FAD binding motif [chemical binding]; other site 443218008114 catalytic residues [active] 443218008115 NAD binding pocket [chemical binding]; other site 443218008116 phosphate binding motif [ion binding]; other site 443218008117 beta-alpha-beta structure motif; other site 443218008118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008119 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218008120 active site 443218008121 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218008122 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218008123 putative di-iron ligands [ion binding]; other site 443218008124 Predicted membrane protein [Function unknown]; Region: COG2311 443218008125 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218008126 Protein of unknown function (DUF418); Region: DUF418; cl12135 443218008127 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443218008128 Helix-turn-helix domains; Region: HTH; cl00088 443218008129 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 443218008130 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443218008131 Bacterial Ig-like domain; Region: Big_5; cl01012 443218008132 Copper resistance protein D; Region: CopD; cl00563 443218008133 FixH; Region: FixH; cl01254 443218008134 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 443218008135 TIGR03086 family protein; Region: TIGR03086 443218008136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218008137 Helix-turn-helix domains; Region: HTH; cl00088 443218008138 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218008139 siderophore binding site; other site 443218008140 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218008141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008142 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218008143 Walker A/P-loop; other site 443218008144 ATP binding site [chemical binding]; other site 443218008145 Q-loop/lid; other site 443218008146 ABC transporter signature motif; other site 443218008147 Walker B; other site 443218008148 D-loop; other site 443218008149 H-loop/switch region; other site 443218008150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008151 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443218008152 NAD(P) binding site [chemical binding]; other site 443218008153 active site 443218008154 Helix-turn-helix domains; Region: HTH; cl00088 443218008155 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443218008156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218008158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008159 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218008160 short chain dehydrogenase; Provisional; Region: PRK08278 443218008161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008162 NAD(P) binding site [chemical binding]; other site 443218008163 active site 443218008164 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218008165 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 443218008166 putative di-iron ligands [ion binding]; other site 443218008167 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 443218008168 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 443218008169 FAD binding pocket [chemical binding]; other site 443218008170 FAD binding motif [chemical binding]; other site 443218008171 phosphate binding motif [ion binding]; other site 443218008172 beta-alpha-beta structure motif; other site 443218008173 NAD(p) ribose binding residues [chemical binding]; other site 443218008174 NAD binding pocket [chemical binding]; other site 443218008175 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 443218008176 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218008177 catalytic loop [active] 443218008178 iron binding site [ion binding]; other site 443218008179 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218008180 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008181 enoyl-CoA hydratase; Provisional; Region: PRK06688 443218008182 substrate binding site [chemical binding]; other site 443218008183 oxyanion hole (OAH) forming residues; other site 443218008184 trimer interface [polypeptide binding]; other site 443218008185 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218008186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008187 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218008189 active site 443218008190 phosphorylation site [posttranslational modification] 443218008191 intermolecular recognition site; other site 443218008192 dimerization interface [polypeptide binding]; other site 443218008193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008194 DNA binding residues [nucleotide binding] 443218008195 dimerization interface [polypeptide binding]; other site 443218008196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218008197 Histidine kinase; Region: HisKA_3; pfam07730 443218008198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218008199 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443218008200 nudix motif; other site 443218008201 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 443218008202 META domain; Region: META; cl01245 443218008203 META domain; Region: META; cl01245 443218008204 TIGR03086 family protein; Region: TIGR03086 443218008205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218008206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218008207 active site 443218008208 phosphorylation site [posttranslational modification] 443218008209 intermolecular recognition site; other site 443218008210 dimerization interface [polypeptide binding]; other site 443218008211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008212 DNA binding residues [nucleotide binding] 443218008213 dimerization interface [polypeptide binding]; other site 443218008214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218008215 Histidine kinase; Region: HisKA_3; pfam07730 443218008216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218008217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218008218 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218008219 Walker A/P-loop; other site 443218008220 ATP binding site [chemical binding]; other site 443218008221 Q-loop/lid; other site 443218008222 ABC transporter signature motif; other site 443218008223 Walker B; other site 443218008224 D-loop; other site 443218008225 H-loop/switch region; other site 443218008226 YceI-like domain; Region: YceI; cl01001 443218008227 YceI-like domain; Region: YceI; cl01001 443218008228 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 443218008229 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 443218008230 putative FMN binding site [chemical binding]; other site 443218008231 NADPH bind site [chemical binding]; other site 443218008232 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 443218008233 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 443218008234 catalytic triad [active] 443218008235 Domain of unknown function (DUF309); Region: DUF309; cl00667 443218008236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218008237 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 443218008238 putative FMN binding site [chemical binding]; other site 443218008239 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443218008240 putative dimer interface [polypeptide binding]; other site 443218008241 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 443218008242 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 443218008243 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 443218008244 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218008245 Phospholipid methyltransferase; Region: PEMT; cl00763 443218008246 SCP-2 sterol transfer family; Region: SCP2; cl01225 443218008247 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443218008248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008249 S-adenosylmethionine binding site [chemical binding]; other site 443218008250 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 443218008251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008252 S-adenosylmethionine binding site [chemical binding]; other site 443218008253 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 443218008254 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443218008255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008256 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218008257 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 443218008258 nucleophilic elbow; other site 443218008259 catalytic triad; other site 443218008260 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443218008261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218008262 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218008263 CoenzymeA binding site [chemical binding]; other site 443218008264 subunit interaction site [polypeptide binding]; other site 443218008265 PHB binding site; other site 443218008266 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 443218008267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218008268 dimer interface [polypeptide binding]; other site 443218008269 putative PBP binding regions; other site 443218008270 ABC-ATPase subunit interface; other site 443218008271 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218008272 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 443218008273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218008274 ABC-ATPase subunit interface; other site 443218008275 dimer interface [polypeptide binding]; other site 443218008276 putative PBP binding regions; other site 443218008277 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218008278 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218008279 Walker A/P-loop; other site 443218008280 ATP binding site [chemical binding]; other site 443218008281 Q-loop/lid; other site 443218008282 ABC transporter signature motif; other site 443218008283 Walker B; other site 443218008284 D-loop; other site 443218008285 H-loop/switch region; other site 443218008286 Helix-turn-helix domains; Region: HTH; cl00088 443218008287 Peptidase family M48; Region: Peptidase_M48; cl12018 443218008288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008289 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443218008290 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443218008291 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443218008292 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218008293 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443218008294 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 443218008295 active site 443218008296 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443218008297 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218008298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218008299 Transporter associated domain; Region: CorC_HlyC; cl08393 443218008300 Domain of unknown function DUF21; Region: DUF21; pfam01595 443218008301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443218008302 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 443218008303 active site 443218008304 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443218008305 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443218008306 putative active site [active] 443218008307 putative metal binding site [ion binding]; other site 443218008308 glycine dehydrogenase; Provisional; Region: PRK05367 443218008309 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443218008310 tetramer interface [polypeptide binding]; other site 443218008311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008312 catalytic residue [active] 443218008313 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443218008314 tetramer interface [polypeptide binding]; other site 443218008315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008316 catalytic residue [active] 443218008317 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 443218008318 DNA binding residues [nucleotide binding] 443218008319 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218008320 putative dimer interface [polypeptide binding]; other site 443218008321 Bifunctional nuclease; Region: DNase-RNase; cl00553 443218008322 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443218008323 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218008324 DNA binding residues [nucleotide binding] 443218008325 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 443218008326 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443218008327 phosphopeptide binding site; other site 443218008328 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443218008329 lipoyl attachment site [posttranslational modification]; other site 443218008330 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218008331 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 443218008332 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 443218008333 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218008334 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 443218008335 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 443218008336 Walker A/P-loop; other site 443218008337 ATP binding site [chemical binding]; other site 443218008338 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 443218008339 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 443218008340 ABC transporter signature motif; other site 443218008341 Walker B; other site 443218008342 D-loop; other site 443218008343 H-loop/switch region; other site 443218008344 Acylphosphatase; Region: Acylphosphatase; cl00551 443218008345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008346 putative substrate translocation pore; other site 443218008347 OsmC-like protein; Region: OsmC; cl00767 443218008348 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218008349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008350 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218008351 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443218008352 putative NAD(P) binding site [chemical binding]; other site 443218008353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008354 Helix-turn-helix domains; Region: HTH; cl00088 443218008355 short chain dehydrogenase; Provisional; Region: PRK08226 443218008356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008357 NAD(P) binding site [chemical binding]; other site 443218008358 active site 443218008359 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443218008360 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443218008361 DNA binding site [nucleotide binding] 443218008362 catalytic residue [active] 443218008363 H2TH interface [polypeptide binding]; other site 443218008364 putative catalytic residues [active] 443218008365 turnover-facilitating residue; other site 443218008366 intercalation triad [nucleotide binding]; other site 443218008367 8OG recognition residue [nucleotide binding]; other site 443218008368 putative reading head residues; other site 443218008369 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218008370 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218008371 ribonuclease III; Reviewed; Region: rnc; PRK00102 443218008372 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443218008373 dimerization interface [polypeptide binding]; other site 443218008374 active site 443218008375 metal binding site [ion binding]; metal-binding site 443218008376 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443218008377 dsRNA binding site [nucleotide binding]; other site 443218008378 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 443218008379 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 443218008380 Plant ATP synthase F0; Region: YMF19; cl07975 443218008381 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443218008382 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443218008383 active site 443218008384 (T/H)XGH motif; other site 443218008385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008386 S-adenosylmethionine binding site [chemical binding]; other site 443218008387 pyruvate carboxylase; Reviewed; Region: PRK12999 443218008388 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218008389 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218008390 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218008391 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443218008392 active site 443218008393 catalytic residues [active] 443218008394 metal binding site [ion binding]; metal-binding site 443218008395 homodimer binding site [polypeptide binding]; other site 443218008396 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218008397 carboxyltransferase (CT) interaction site; other site 443218008398 biotinylation site [posttranslational modification]; other site 443218008399 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 443218008400 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443218008401 generic binding surface II; other site 443218008402 ssDNA binding site; other site 443218008403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218008404 ATP binding site [chemical binding]; other site 443218008405 putative Mg++ binding site [ion binding]; other site 443218008406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218008407 nucleotide binding region [chemical binding]; other site 443218008408 ATP-binding site [chemical binding]; other site 443218008409 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 443218008410 DAK2 domain; Region: Dak2; cl03685 443218008411 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 443218008412 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 443218008413 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443218008414 ligand binding site [chemical binding]; other site 443218008415 active site 443218008416 UGI interface [polypeptide binding]; other site 443218008417 catalytic site [active] 443218008418 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 443218008419 putative active site [active] 443218008420 putative catalytic site [active] 443218008421 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 443218008422 Helix-turn-helix domains; Region: HTH; cl00088 443218008423 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443218008424 AMP-binding enzyme; Region: AMP-binding; cl15778 443218008425 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218008426 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 443218008427 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 443218008428 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 443218008429 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218008430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008431 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218008432 FAD binding site [chemical binding]; other site 443218008433 homotetramer interface [polypeptide binding]; other site 443218008434 substrate binding pocket [chemical binding]; other site 443218008435 catalytic base [active] 443218008436 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218008437 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218008438 putative di-iron ligands [ion binding]; other site 443218008439 thiamine monophosphate kinase; Provisional; Region: PRK05731 443218008440 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443218008441 ATP binding site [chemical binding]; other site 443218008442 dimerization interface [polypeptide binding]; other site 443218008443 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443218008444 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443218008445 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443218008446 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218008447 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443218008448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008449 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443218008450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218008451 polyphosphate kinase; Provisional; Region: PRK05443 443218008452 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443218008453 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443218008454 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443218008455 putative domain interface [polypeptide binding]; other site 443218008456 putative active site [active] 443218008457 catalytic site [active] 443218008458 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443218008459 putative active site [active] 443218008460 catalytic site [active] 443218008461 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443218008462 active site 443218008463 Ap6A binding site [chemical binding]; other site 443218008464 nudix motif; other site 443218008465 metal binding site [ion binding]; metal-binding site 443218008466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443218008467 catalytic core [active] 443218008468 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443218008469 substrate binding site [chemical binding]; other site 443218008470 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443218008471 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443218008472 substrate binding site [chemical binding]; other site 443218008473 ligand binding site [chemical binding]; other site 443218008474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218008475 Helix-turn-helix domains; Region: HTH; cl00088 443218008476 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218008477 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443218008478 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443218008479 HIGH motif; other site 443218008480 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443218008481 active site 443218008482 KMSKS motif; other site 443218008483 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443218008484 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443218008485 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 443218008486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218008487 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 443218008488 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443218008489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008490 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443218008491 putative L-serine binding site [chemical binding]; other site 443218008492 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443218008493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008494 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443218008495 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443218008496 dimer interface [polypeptide binding]; other site 443218008497 putative valine binding site [chemical binding]; other site 443218008498 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443218008499 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443218008500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218008501 PYR/PP interface [polypeptide binding]; other site 443218008502 dimer interface [polypeptide binding]; other site 443218008503 TPP binding site [chemical binding]; other site 443218008504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 443218008505 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443218008506 TPP-binding site [chemical binding]; other site 443218008507 dimer interface [polypeptide binding]; other site 443218008508 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443218008509 Dehydratase family; Region: ILVD_EDD; cl00340 443218008510 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 443218008511 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443218008512 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443218008513 GatB domain; Region: GatB_Yqey; cl11497 443218008514 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 443218008515 active site 443218008516 ADP/pyrophosphate binding site [chemical binding]; other site 443218008517 dimerization interface [polypeptide binding]; other site 443218008518 allosteric effector site; other site 443218008519 fructose-1,6-bisphosphate binding site; other site 443218008520 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 443218008521 transmembrane helices; other site 443218008522 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 443218008523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218008524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218008525 ATP binding site [chemical binding]; other site 443218008526 Mg2+ binding site [ion binding]; other site 443218008527 G-X-G motif; other site 443218008528 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443218008529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218008530 active site 443218008531 phosphorylation site [posttranslational modification] 443218008532 intermolecular recognition site; other site 443218008533 dimerization interface [polypeptide binding]; other site 443218008534 Helix-turn-helix domains; Region: HTH; cl00088 443218008535 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218008536 Amidase; Region: Amidase; cl11426 443218008537 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 443218008538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218008540 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218008541 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443218008542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218008543 Coenzyme A binding pocket [chemical binding]; other site 443218008544 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443218008545 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443218008546 nucleotide binding pocket [chemical binding]; other site 443218008547 K-X-D-G motif; other site 443218008548 catalytic site [active] 443218008549 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443218008550 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443218008551 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443218008552 Dimer interface [polypeptide binding]; other site 443218008553 BRCT sequence motif; other site 443218008554 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 443218008555 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443218008556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218008557 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 443218008558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218008559 catalytic residue [active] 443218008560 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443218008561 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218008562 putative acyl-acceptor binding pocket; other site 443218008563 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218008564 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 443218008565 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 443218008566 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 443218008567 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 443218008568 Ligand binding site [chemical binding]; other site 443218008569 Electron transfer flavoprotein domain; Region: ETF; pfam01012 443218008570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008571 S-adenosylmethionine binding site [chemical binding]; other site 443218008572 Uncharacterized conserved protein [Function unknown]; Region: COG1543 443218008573 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 443218008574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443218008575 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218008576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218008577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008578 NAD(P) binding site [chemical binding]; other site 443218008579 active site 443218008580 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 443218008581 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 443218008582 trimer interface [polypeptide binding]; other site 443218008583 active site 443218008584 substrate binding site [chemical binding]; other site 443218008585 CoA binding site [chemical binding]; other site 443218008586 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 443218008587 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 443218008588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008589 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 443218008590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008591 S-adenosylmethionine binding site [chemical binding]; other site 443218008592 enoyl-CoA hydratase; Provisional; Region: PRK05862 443218008593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008594 substrate binding site [chemical binding]; other site 443218008595 oxyanion hole (OAH) forming residues; other site 443218008596 trimer interface [polypeptide binding]; other site 443218008597 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218008598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008599 Walker A/P-loop; other site 443218008600 ATP binding site [chemical binding]; other site 443218008601 Q-loop/lid; other site 443218008602 ABC transporter signature motif; other site 443218008603 Walker B; other site 443218008604 D-loop; other site 443218008605 H-loop/switch region; other site 443218008606 glycogen branching enzyme; Provisional; Region: PRK05402 443218008607 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443218008608 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443218008609 active site 443218008610 catalytic site [active] 443218008611 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 443218008612 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 443218008613 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 443218008614 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443218008615 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 443218008616 Domain of unknown function DUF77; Region: DUF77; cl00307 443218008617 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 443218008618 putative acyltransferase; Provisional; Region: PRK05790 443218008619 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218008620 dimer interface [polypeptide binding]; other site 443218008621 active site 443218008622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218008623 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 443218008624 dimer interface [polypeptide binding]; other site 443218008625 substrate binding site [chemical binding]; other site 443218008626 metal binding site [ion binding]; metal-binding site 443218008627 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443218008628 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218008629 TPP-binding site [chemical binding]; other site 443218008630 dimer interface [polypeptide binding]; other site 443218008631 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218008632 PYR/PP interface [polypeptide binding]; other site 443218008633 dimer interface [polypeptide binding]; other site 443218008634 TPP binding site [chemical binding]; other site 443218008635 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218008636 Protein of unknown function DUF91; Region: DUF91; cl00709 443218008637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218008638 dimerization interface [polypeptide binding]; other site 443218008639 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218008640 cyclase homology domain; Region: CHD; cd07302 443218008641 nucleotidyl binding site; other site 443218008642 metal binding site [ion binding]; metal-binding site 443218008643 dimer interface [polypeptide binding]; other site 443218008644 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218008645 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218008646 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443218008647 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443218008648 hinge; other site 443218008649 active site 443218008650 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 443218008651 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 443218008652 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 443218008653 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443218008654 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 443218008655 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443218008656 alpha subunit interaction interface [polypeptide binding]; other site 443218008657 Walker A motif; other site 443218008658 ATP binding site [chemical binding]; other site 443218008659 Walker B motif; other site 443218008660 inhibitor binding site; inhibition site 443218008661 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443218008662 ATP synthase; Region: ATP-synt; cl00365 443218008663 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 443218008664 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443218008665 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 443218008666 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 443218008667 beta subunit interaction interface [polypeptide binding]; other site 443218008668 Walker A motif; other site 443218008669 ATP binding site [chemical binding]; other site 443218008670 Walker B motif; other site 443218008671 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443218008672 Plant ATP synthase F0; Region: YMF19; cl07975 443218008673 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 443218008674 Plant ATP synthase F0; Region: YMF19; cl07975 443218008675 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 443218008676 ATP synthase subunit C; Region: ATP-synt_C; cl00466 443218008677 ATP synthase A chain; Region: ATP-synt_A; cl00413 443218008678 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443218008679 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443218008680 Mg++ binding site [ion binding]; other site 443218008681 putative catalytic motif [active] 443218008682 substrate binding site [chemical binding]; other site 443218008683 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218008684 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218008685 dimer interface [polypeptide binding]; other site 443218008686 active site 443218008687 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218008688 folate binding site [chemical binding]; other site 443218008689 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 443218008690 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443218008691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008692 S-adenosylmethionine binding site [chemical binding]; other site 443218008693 peptide chain release factor 1; Validated; Region: prfA; PRK00591 443218008694 RF-1 domain; Region: RF-1; cl02875 443218008695 RF-1 domain; Region: RF-1; cl02875 443218008696 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 443218008697 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 443218008698 transcription termination factor Rho; Provisional; Region: PRK12608 443218008699 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443218008700 RNA binding site [nucleotide binding]; other site 443218008701 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443218008702 multimer interface [polypeptide binding]; other site 443218008703 Walker A motif; other site 443218008704 ATP binding site [chemical binding]; other site 443218008705 Walker B motif; other site 443218008706 homoserine kinase; Provisional; Region: PRK01212 443218008707 threonine synthase; Reviewed; Region: PRK06721 443218008708 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443218008709 homodimer interface [polypeptide binding]; other site 443218008710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008711 catalytic residue [active] 443218008712 homoserine dehydrogenase; Provisional; Region: PRK06349 443218008713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008714 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443218008715 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443218008716 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443218008717 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443218008718 active site 443218008719 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218008720 substrate binding site [chemical binding]; other site 443218008721 catalytic residues [active] 443218008722 dimer interface [polypeptide binding]; other site 443218008723 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443218008724 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 443218008725 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443218008726 active site 443218008727 HIGH motif; other site 443218008728 KMSK motif region; other site 443218008729 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 443218008730 tRNA binding surface [nucleotide binding]; other site 443218008731 anticodon binding site; other site 443218008732 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 443218008733 Domain of unknown function (DUF305); Region: DUF305; cl15795 443218008734 HEAT repeats; Region: HEAT_2; pfam13646 443218008735 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 443218008736 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218008737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008738 Helix-turn-helix domains; Region: HTH; cl00088 443218008739 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 443218008740 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 443218008741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218008742 active site 443218008743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218008744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218008745 dimerization interface [polypeptide binding]; other site 443218008746 DNA binding residues [nucleotide binding] 443218008747 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 443218008748 Helix-turn-helix domains; Region: HTH; cl00088 443218008749 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218008750 AMP-binding enzyme; Region: AMP-binding; cl15778 443218008751 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218008752 enoyl-CoA hydratase; Provisional; Region: PRK08252 443218008753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008754 substrate binding site [chemical binding]; other site 443218008755 oxyanion hole (OAH) forming residues; other site 443218008756 trimer interface [polypeptide binding]; other site 443218008757 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218008758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218008759 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218008760 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218008761 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218008762 intersubunit interface [polypeptide binding]; other site 443218008763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443218008765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218008766 putative substrate translocation pore; other site 443218008767 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 443218008768 HIT family signature motif; other site 443218008769 catalytic residue [active] 443218008770 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 443218008771 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218008772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008773 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 443218008774 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 443218008775 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443218008776 conserved cys residue [active] 443218008777 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 443218008778 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443218008779 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 443218008780 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218008781 ATP binding site [chemical binding]; other site 443218008782 Mg++ binding site [ion binding]; other site 443218008783 motif III; other site 443218008784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218008785 nucleotide binding region [chemical binding]; other site 443218008786 ATP-binding site [chemical binding]; other site 443218008787 DbpA RNA binding domain; Region: DbpA; pfam03880 443218008788 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218008789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443218008790 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443218008791 nucleophile elbow; other site 443218008792 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218008793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218008794 substrate binding site [chemical binding]; other site 443218008795 oxyanion hole (OAH) forming residues; other site 443218008796 trimer interface [polypeptide binding]; other site 443218008797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218008798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218008799 active site 443218008800 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218008801 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 443218008802 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 443218008803 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218008804 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 443218008805 putative dimer interface [polypeptide binding]; other site 443218008806 N-terminal domain interface [polypeptide binding]; other site 443218008807 putative substrate binding pocket (H-site) [chemical binding]; other site 443218008808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218008809 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218008810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008811 Walker A/P-loop; other site 443218008812 ATP binding site [chemical binding]; other site 443218008813 Q-loop/lid; other site 443218008814 ABC transporter signature motif; other site 443218008815 Walker B; other site 443218008816 D-loop; other site 443218008817 H-loop/switch region; other site 443218008818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443218008819 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218008820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008821 Walker A/P-loop; other site 443218008822 ATP binding site [chemical binding]; other site 443218008823 Q-loop/lid; other site 443218008824 ABC transporter signature motif; other site 443218008825 Walker B; other site 443218008826 D-loop; other site 443218008827 H-loop/switch region; other site 443218008828 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443218008829 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443218008830 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 443218008831 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443218008832 TPP-binding site [chemical binding]; other site 443218008833 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443218008834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218008835 Helix-turn-helix domains; Region: HTH; cl00088 443218008836 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218008837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008838 short chain dehydrogenase; Provisional; Region: PRK07832 443218008839 classical (c) SDRs; Region: SDR_c; cd05233 443218008840 NAD(P) binding site [chemical binding]; other site 443218008841 active site 443218008842 Malic enzyme, N-terminal domain; Region: malic; pfam00390 443218008843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218008844 NAD(P) binding pocket [chemical binding]; other site 443218008845 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 443218008846 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 443218008847 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443218008848 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218008849 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218008850 Domain of unknown function DUF59; Region: DUF59; cl00941 443218008851 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443218008852 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 443218008853 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218008854 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 443218008855 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 443218008856 Putative zinc-finger; Region: zf-HC2; cl15806 443218008857 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 443218008858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218008859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218008860 DNA binding residues [nucleotide binding] 443218008861 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443218008862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218008863 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443218008864 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443218008865 ligand binding site; other site 443218008866 oligomer interface; other site 443218008867 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443218008868 sulfate 1 binding site; other site 443218008869 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 443218008870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218008871 S-adenosylmethionine binding site [chemical binding]; other site 443218008872 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443218008873 interface (dimer of trimers) [polypeptide binding]; other site 443218008874 Substrate-binding/catalytic site; other site 443218008875 Zn-binding sites [ion binding]; other site 443218008876 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 443218008877 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 443218008878 DivIVA domain; Region: DivI1A_domain; TIGR03544 443218008879 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 443218008880 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443218008881 Ligand binding site; other site 443218008882 Putative Catalytic site; other site 443218008883 DXD motif; other site 443218008884 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 443218008885 substrate binding pocket [chemical binding]; other site 443218008886 dimer interface [polypeptide binding]; other site 443218008887 inhibitor binding site; inhibition site 443218008888 Ion channel; Region: Ion_trans_2; cl11596 443218008889 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443218008890 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 443218008891 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443218008892 Helix-turn-helix domains; Region: HTH; cl00088 443218008893 Transport protein; Region: actII; TIGR00833 443218008894 Transport protein; Region: actII; TIGR00833 443218008895 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 443218008896 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443218008897 metal binding site [ion binding]; metal-binding site 443218008898 putative dimer interface [polypeptide binding]; other site 443218008899 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443218008900 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443218008901 putative trimer interface [polypeptide binding]; other site 443218008902 putative CoA binding site [chemical binding]; other site 443218008903 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 443218008904 acyl-CoA synthetase; Validated; Region: PRK07787 443218008905 AMP-binding enzyme; Region: AMP-binding; cl15778 443218008906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218008907 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 443218008908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218008909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218008910 homodimer interface [polypeptide binding]; other site 443218008911 catalytic residue [active] 443218008912 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 443218008913 4Fe-4S binding domain; Region: Fer4; cl02805 443218008914 FO synthase; Reviewed; Region: fbiC; PRK09234 443218008915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218008916 FeS/SAM binding site; other site 443218008917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218008918 FeS/SAM binding site; other site 443218008919 Bacterial PH domain; Region: DUF304; cl01348 443218008920 Bacterial PH domain; Region: DUF304; cl01348 443218008921 Bacterial PH domain; Region: DUF304; cl01348 443218008922 Bacterial PH domain; Region: DUF304; cl01348 443218008923 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443218008924 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443218008925 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443218008926 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 443218008927 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443218008928 G1 box; other site 443218008929 putative GEF interaction site [polypeptide binding]; other site 443218008930 GTP/Mg2+ binding site [chemical binding]; other site 443218008931 Switch I region; other site 443218008932 G2 box; other site 443218008933 G3 box; other site 443218008934 Switch II region; other site 443218008935 G4 box; other site 443218008936 G5 box; other site 443218008937 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443218008938 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443218008939 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443218008940 active site 443218008941 8-oxo-dGMP binding site [chemical binding]; other site 443218008942 nudix motif; other site 443218008943 metal binding site [ion binding]; metal-binding site 443218008944 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218008945 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 443218008946 Walker A/P-loop; other site 443218008947 ATP binding site [chemical binding]; other site 443218008948 Q-loop/lid; other site 443218008949 ABC transporter signature motif; other site 443218008950 Walker B; other site 443218008951 D-loop; other site 443218008952 H-loop/switch region; other site 443218008953 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 443218008954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218008955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218008956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218008957 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 443218008958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218008959 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 443218008960 aromatic arch; other site 443218008961 DCoH dimer interaction site [polypeptide binding]; other site 443218008962 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 443218008963 DCoH tetramer interaction site [polypeptide binding]; other site 443218008964 substrate binding site [chemical binding]; other site 443218008965 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 443218008966 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443218008967 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443218008968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443218008969 catalytic residue [active] 443218008970 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218008971 NAD-dependent deacetylase; Provisional; Region: PRK00481 443218008972 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 443218008973 NAD+ binding site [chemical binding]; other site 443218008974 substrate binding site [chemical binding]; other site 443218008975 Zn binding site [ion binding]; other site 443218008976 PspC domain; Region: PspC; cl00864 443218008977 DNA polymerase IV; Validated; Region: PRK03352 443218008978 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443218008979 active site 443218008980 DNA binding site [nucleotide binding] 443218008981 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218008982 GTP-binding protein YchF; Reviewed; Region: PRK09601 443218008983 YchF GTPase; Region: YchF; cd01900 443218008984 G1 box; other site 443218008985 GTP/Mg2+ binding site [chemical binding]; other site 443218008986 Switch I region; other site 443218008987 G2 box; other site 443218008988 Switch II region; other site 443218008989 G3 box; other site 443218008990 G4 box; other site 443218008991 G5 box; other site 443218008992 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 443218008993 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218008994 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443218008995 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 443218008996 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443218008997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218008998 Walker A/P-loop; other site 443218008999 ATP binding site [chemical binding]; other site 443218009000 Q-loop/lid; other site 443218009001 Walker B; other site 443218009002 D-loop; other site 443218009003 H-loop/switch region; other site 443218009004 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 443218009005 ABC transporter signature motif; other site 443218009006 Walker B; other site 443218009007 D-loop; other site 443218009008 H-loop/switch region; other site 443218009009 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 443218009010 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443218009011 active site 443218009012 metal binding site [ion binding]; metal-binding site 443218009013 DNA binding site [nucleotide binding] 443218009014 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 443218009015 RmuC family; Region: RmuC; pfam02646 443218009016 LytB protein; Region: LYTB; cl00507 443218009017 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 443218009018 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 443218009019 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443218009020 generic binding surface II; other site 443218009021 generic binding surface I; other site 443218009022 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 443218009023 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443218009024 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443218009025 putative active site [active] 443218009026 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443218009027 Class II fumarases; Region: Fumarase_classII; cd01362 443218009028 active site 443218009029 tetramer interface [polypeptide binding]; other site 443218009030 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443218009031 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443218009032 putative active site [active] 443218009033 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009034 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443218009035 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443218009036 dimer interface [polypeptide binding]; other site 443218009037 active site 443218009038 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443218009039 folate binding site [chemical binding]; other site 443218009040 pantothenate kinase; Provisional; Region: PRK05439 443218009041 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 443218009042 ATP-binding site [chemical binding]; other site 443218009043 CoA-binding site [chemical binding]; other site 443218009044 Mg2+-binding site [ion binding]; other site 443218009045 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443218009046 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443218009047 catalytic residue [active] 443218009048 putative FPP diphosphate binding site; other site 443218009049 putative FPP binding hydrophobic cleft; other site 443218009050 dimer interface [polypeptide binding]; other site 443218009051 putative IPP diphosphate binding site; other site 443218009052 Haemolysin-III related; Region: HlyIII; cl03831 443218009053 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218009054 Helix-turn-helix domains; Region: HTH; cl00088 443218009055 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218009056 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218009057 Walker A/P-loop; other site 443218009058 ATP binding site [chemical binding]; other site 443218009059 Q-loop/lid; other site 443218009060 ABC transporter signature motif; other site 443218009061 Walker B; other site 443218009062 D-loop; other site 443218009063 H-loop/switch region; other site 443218009064 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218009065 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218009066 NeuB family; Region: NeuB; cl00496 443218009067 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 443218009068 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443218009069 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443218009070 catalytic residues [active] 443218009071 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443218009072 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443218009073 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443218009074 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443218009075 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443218009076 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218009077 cystathionine gamma-synthase; Provisional; Region: PRK07811 443218009078 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218009079 homodimer interface [polypeptide binding]; other site 443218009080 substrate-cofactor binding pocket; other site 443218009081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009082 catalytic residue [active] 443218009083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009084 Helix-turn-helix domains; Region: HTH; cl00088 443218009085 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 443218009086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009087 active site 443218009088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009089 enoyl-CoA hydratase; Provisional; Region: PRK07799 443218009090 substrate binding site [chemical binding]; other site 443218009091 oxyanion hole (OAH) forming residues; other site 443218009092 trimer interface [polypeptide binding]; other site 443218009093 enoyl-CoA hydratase; Provisional; Region: PRK12478 443218009094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218009095 substrate binding site [chemical binding]; other site 443218009096 oxyanion hole (OAH) forming residues; other site 443218009097 trimer interface [polypeptide binding]; other site 443218009098 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 443218009099 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 443218009100 transketolase; Reviewed; Region: PRK05899 443218009101 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443218009102 TPP-binding site [chemical binding]; other site 443218009103 dimer interface [polypeptide binding]; other site 443218009104 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443218009105 PYR/PP interface [polypeptide binding]; other site 443218009106 dimer interface [polypeptide binding]; other site 443218009107 TPP binding site [chemical binding]; other site 443218009108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218009109 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443218009110 putative active site [active] 443218009111 transaldolase; Provisional; Region: PRK03903 443218009112 catalytic residue [active] 443218009113 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 443218009114 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 443218009115 putative [Fe4-S4] binding site [ion binding]; other site 443218009116 putative molybdopterin cofactor binding site [chemical binding]; other site 443218009117 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 443218009118 putative molybdopterin cofactor binding site; other site 443218009119 FAD binding domain; Region: FAD_binding_4; pfam01565 443218009120 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443218009121 classical (c) SDRs; Region: SDR_c; cd05233 443218009122 NAD(P) binding site [chemical binding]; other site 443218009123 active site 443218009124 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 443218009125 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009126 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218009127 active site 443218009128 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 443218009129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218009130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443218009131 active site residue [active] 443218009132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218009133 DoxX; Region: DoxX; cl00976 443218009134 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 443218009135 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 443218009136 DNA binding residues [nucleotide binding] 443218009137 dimer interface [polypeptide binding]; other site 443218009138 [2Fe-2S] cluster binding site [ion binding]; other site 443218009139 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443218009140 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443218009141 dimer interface [polypeptide binding]; other site 443218009142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009143 catalytic residue [active] 443218009144 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443218009145 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443218009146 active site 443218009147 catalytic triad [active] 443218009148 oxyanion hole [active] 443218009149 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 443218009150 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218009151 dimer interface [polypeptide binding]; other site 443218009152 active site 443218009153 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218009154 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218009155 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 443218009156 active site 443218009157 trimer interface [polypeptide binding]; other site 443218009158 allosteric site; other site 443218009159 active site lid [active] 443218009160 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443218009161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009162 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 443218009163 active site 443218009164 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218009165 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218009166 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 443218009167 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218009168 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 443218009169 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 443218009170 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 443218009171 active site turn [active] 443218009172 phosphorylation site [posttranslational modification] 443218009173 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 443218009174 HPr interaction site; other site 443218009175 glycerol kinase (GK) interaction site [polypeptide binding]; other site 443218009176 active site 443218009177 phosphorylation site [posttranslational modification] 443218009178 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 443218009179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218009180 active site 443218009181 catalytic tetrad [active] 443218009182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443218009183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009184 DNA-binding site [nucleotide binding]; DNA binding site 443218009185 UTRA domain; Region: UTRA; cl01230 443218009186 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 443218009187 Flavin Reductases; Region: FlaRed; cl00801 443218009188 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218009189 putative dimer interface [polypeptide binding]; other site 443218009190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009191 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218009192 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 443218009193 Protein of unknown function (DUF501); Region: DUF501; cl00652 443218009194 Septum formation initiator; Region: DivIC; cl11433 443218009195 enolase; Provisional; Region: eno; PRK00077 443218009196 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443218009197 dimer interface [polypeptide binding]; other site 443218009198 metal binding site [ion binding]; metal-binding site 443218009199 substrate binding pocket [chemical binding]; other site 443218009200 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 443218009201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218009202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218009203 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 443218009204 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 443218009205 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443218009206 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 443218009207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218009208 ATP binding site [chemical binding]; other site 443218009209 putative Mg++ binding site [ion binding]; other site 443218009210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009211 nucleotide binding region [chemical binding]; other site 443218009212 ATP-binding site [chemical binding]; other site 443218009213 TRCF domain; Region: TRCF; cl04088 443218009214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009215 Helix-turn-helix domains; Region: HTH; cl00088 443218009216 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 443218009217 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443218009218 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443218009219 Substrate binding site; other site 443218009220 Mg++ binding site; other site 443218009221 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443218009222 active site 443218009223 substrate binding site [chemical binding]; other site 443218009224 CoA binding site [chemical binding]; other site 443218009225 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443218009226 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443218009227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218009228 active site 443218009229 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 443218009230 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443218009231 5S rRNA interface [nucleotide binding]; other site 443218009232 CTC domain interface [polypeptide binding]; other site 443218009233 L16 interface [polypeptide binding]; other site 443218009234 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443218009235 putative active site [active] 443218009236 catalytic residue [active] 443218009237 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 443218009238 AMP-binding enzyme; Region: AMP-binding; cl15778 443218009239 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 443218009240 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 443218009241 G1 box; other site 443218009242 putative GEF interaction site [polypeptide binding]; other site 443218009243 GTP/Mg2+ binding site [chemical binding]; other site 443218009244 Switch I region; other site 443218009245 G2 box; other site 443218009246 G3 box; other site 443218009247 Switch II region; other site 443218009248 G4 box; other site 443218009249 G5 box; other site 443218009250 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 443218009251 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443218009252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009253 DNA-binding site [nucleotide binding]; DNA binding site 443218009254 FCD domain; Region: FCD; cl11656 443218009255 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 443218009256 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 443218009257 ATP-binding site [chemical binding]; other site 443218009258 Gluconate-6-phosphate binding site [chemical binding]; other site 443218009259 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 443218009260 GntP family permease; Region: GntP_permease; pfam02447 443218009261 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443218009262 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 443218009263 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 443218009264 putative dimer interface [polypeptide binding]; other site 443218009265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009266 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218009267 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218009268 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 443218009269 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443218009270 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218009271 ABC transporter; Region: ABC_tran_2; pfam12848 443218009272 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 443218009273 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 443218009274 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443218009275 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443218009276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218009277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 443218009278 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443218009279 Domain of unknown function (DUF348); Region: DUF348; pfam03990 443218009280 G5 domain; Region: G5; pfam07501 443218009281 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 443218009282 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443218009283 active site 443218009284 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 443218009285 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443218009286 active site 443218009287 KMSKS motif; other site 443218009288 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443218009289 tRNA binding surface [nucleotide binding]; other site 443218009290 anticodon binding site; other site 443218009291 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 443218009292 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 443218009293 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218009294 Predicted methyltransferases [General function prediction only]; Region: COG0313 443218009295 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218009296 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 443218009297 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 443218009298 DoxX; Region: DoxX; cl00976 443218009299 DoxX; Region: DoxX; cl00976 443218009300 Predicted transcriptional regulators [Transcription]; Region: COG1725 443218009301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009302 DNA-binding site [nucleotide binding]; DNA binding site 443218009303 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 443218009304 ArsC family; Region: ArsC; pfam03960 443218009305 catalytic residues [active] 443218009306 short chain dehydrogenase; Validated; Region: PRK05855 443218009307 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 443218009308 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 443218009309 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443218009310 BCCT family transporter; Region: BCCT; cl00569 443218009311 high affinity sulphate transporter 1; Region: sulP; TIGR00815 443218009312 Sulfate transporter family; Region: Sulfate_transp; cl15842 443218009313 Sulfate transporter family; Region: Sulfate_transp; cl15842 443218009314 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443218009315 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 443218009316 putative hydrophobic ligand binding site [chemical binding]; other site 443218009317 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218009318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443218009319 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 443218009320 ATP binding site [chemical binding]; other site 443218009321 putative Mg++ binding site [ion binding]; other site 443218009322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009323 nucleotide binding region [chemical binding]; other site 443218009324 ATP-binding site [chemical binding]; other site 443218009325 DEAD/H associated; Region: DEAD_assoc; pfam08494 443218009326 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 443218009327 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443218009328 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443218009329 putative DNA binding site [nucleotide binding]; other site 443218009330 catalytic residue [active] 443218009331 putative H2TH interface [polypeptide binding]; other site 443218009332 putative catalytic residues [active] 443218009333 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443218009334 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443218009335 RES domain; Region: RES; cl02411 443218009336 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443218009337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218009338 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443218009339 intersubunit interface [polypeptide binding]; other site 443218009340 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 443218009341 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 443218009342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443218009343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218009344 active site 443218009345 ChaB; Region: ChaB; cl01887 443218009346 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 443218009347 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443218009348 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 443218009349 Walker A/P-loop; other site 443218009350 ATP binding site [chemical binding]; other site 443218009351 Q-loop/lid; other site 443218009352 ABC transporter signature motif; other site 443218009353 Walker B; other site 443218009354 D-loop; other site 443218009355 H-loop/switch region; other site 443218009356 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443218009357 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 443218009358 FtsX-like permease family; Region: FtsX; cl15850 443218009359 FtsX-like permease family; Region: FtsX; cl15850 443218009360 Domain of unknown function DUF302; Region: DUF302; cl01364 443218009361 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443218009362 putative homodimer interface [polypeptide binding]; other site 443218009363 putative homotetramer interface [polypeptide binding]; other site 443218009364 putative allosteric switch controlling residues; other site 443218009365 putative metal binding site [ion binding]; other site 443218009366 putative homodimer-homodimer interface [polypeptide binding]; other site 443218009367 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443218009368 Helix-turn-helix domains; Region: HTH; cl00088 443218009369 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218009370 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218009371 Walker A/P-loop; other site 443218009372 ATP binding site [chemical binding]; other site 443218009373 Q-loop/lid; other site 443218009374 ABC transporter signature motif; other site 443218009375 Walker B; other site 443218009376 D-loop; other site 443218009377 H-loop/switch region; other site 443218009378 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218009379 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218009380 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218009381 classical (c) SDRs; Region: SDR_c; cd05233 443218009382 NAD(P) binding site [chemical binding]; other site 443218009383 active site 443218009384 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 443218009385 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218009386 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443218009387 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443218009388 dimer interface [polypeptide binding]; other site 443218009389 putative functional site; other site 443218009390 putative MPT binding site; other site 443218009391 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 443218009392 active site 443218009393 tetramer interface; other site 443218009394 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 443218009395 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 443218009396 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 443218009397 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 443218009398 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 443218009399 catalytic residues [active] 443218009400 catalytic nucleophile [active] 443218009401 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218009402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443218009403 Probable transposase; Region: OrfB_IS605; pfam01385 443218009404 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218009405 SAF domain; Region: SAF; cl00555 443218009406 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443218009407 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 443218009408 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443218009409 MPT binding site; other site 443218009410 trimer interface [polypeptide binding]; other site 443218009411 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443218009412 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218009413 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218009414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218009415 dimerization interface [polypeptide binding]; other site 443218009416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218009417 dimer interface [polypeptide binding]; other site 443218009418 phosphorylation site [posttranslational modification] 443218009419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218009420 ATP binding site [chemical binding]; other site 443218009421 Mg2+ binding site [ion binding]; other site 443218009422 G-X-G motif; other site 443218009423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218009424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218009425 active site 443218009426 phosphorylation site [posttranslational modification] 443218009427 intermolecular recognition site; other site 443218009428 dimerization interface [polypeptide binding]; other site 443218009429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218009430 DNA binding site [nucleotide binding] 443218009431 UPF0126 domain; Region: UPF0126; pfam03458 443218009432 UPF0126 domain; Region: UPF0126; pfam03458 443218009433 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 443218009434 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218009435 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 443218009436 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 443218009437 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 443218009438 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 443218009439 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 443218009440 Membrane transport protein; Region: Mem_trans; cl09117 443218009441 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443218009442 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443218009443 purine monophosphate binding site [chemical binding]; other site 443218009444 dimer interface [polypeptide binding]; other site 443218009445 putative catalytic residues [active] 443218009446 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443218009447 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443218009448 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443218009449 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443218009450 active site 443218009451 substrate binding site [chemical binding]; other site 443218009452 cosubstrate binding site; other site 443218009453 catalytic site [active] 443218009454 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443218009455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218009456 CoA-ligase; Region: Ligase_CoA; cl02894 443218009457 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443218009458 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218009459 CoA-ligase; Region: Ligase_CoA; cl02894 443218009460 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218009461 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443218009462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009463 Family description; Region: UvrD_C_2; cl15862 443218009464 Chorismate mutase type II; Region: CM_2; cl00693 443218009465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218009466 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218009467 tetramerization interface [polypeptide binding]; other site 443218009468 NAD(P) binding site [chemical binding]; other site 443218009469 catalytic residues [active] 443218009470 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 443218009471 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443218009472 active site 443218009473 dimer interface [polypeptide binding]; other site 443218009474 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 443218009475 dimer interface [polypeptide binding]; other site 443218009476 active site 443218009477 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218009478 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218009479 active site 443218009480 ATP binding site [chemical binding]; other site 443218009481 substrate binding site [chemical binding]; other site 443218009482 activation loop (A-loop); other site 443218009483 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 443218009484 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 443218009485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009486 Helix-turn-helix domains; Region: HTH; cl00088 443218009487 Cutinase; Region: Cutinase; pfam01083 443218009488 Cutinase; Region: Cutinase; pfam01083 443218009489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443218009490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009491 DNA-binding site [nucleotide binding]; DNA binding site 443218009492 FCD domain; Region: FCD; cl11656 443218009493 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218009494 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218009495 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443218009496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218009497 putative amidase; Provisional; Region: PRK06169 443218009498 Amidase; Region: Amidase; cl11426 443218009499 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443218009500 heme-binding site [chemical binding]; other site 443218009501 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218009502 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218009503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009504 active site 443218009505 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218009506 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 443218009507 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218009508 Walker A/P-loop; other site 443218009509 ATP binding site [chemical binding]; other site 443218009510 Q-loop/lid; other site 443218009511 ABC transporter signature motif; other site 443218009512 Walker B; other site 443218009513 D-loop; other site 443218009514 H-loop/switch region; other site 443218009515 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218009516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009517 Helix-turn-helix domains; Region: HTH; cl00088 443218009518 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 443218009519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218009520 inhibitor-cofactor binding pocket; inhibition site 443218009521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218009522 catalytic residue [active] 443218009523 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218009524 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443218009525 tetramerization interface [polypeptide binding]; other site 443218009526 NAD(P) binding site [chemical binding]; other site 443218009527 catalytic residues [active] 443218009528 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218009529 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218009530 putative di-iron ligands [ion binding]; other site 443218009531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218009532 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443218009533 substrate binding pocket [chemical binding]; other site 443218009534 membrane-bound complex binding site; other site 443218009535 hinge residues; other site 443218009536 glutamate dehydrogenase; Provisional; Region: PRK09414 443218009537 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 443218009538 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 443218009539 NAD(P) binding site [chemical binding]; other site 443218009540 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218009541 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218009542 putative di-iron ligands [ion binding]; other site 443218009543 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218009544 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218009545 FAD binding pocket [chemical binding]; other site 443218009546 FAD binding motif [chemical binding]; other site 443218009547 phosphate binding motif [ion binding]; other site 443218009548 beta-alpha-beta structure motif; other site 443218009549 NAD binding pocket [chemical binding]; other site 443218009550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218009551 catalytic loop [active] 443218009552 iron binding site [ion binding]; other site 443218009553 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 443218009554 Helix-turn-helix domains; Region: HTH; cl00088 443218009555 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 443218009556 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443218009557 catalytic triad [active] 443218009558 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218009559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009560 Helix-turn-helix domains; Region: HTH; cl00088 443218009561 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 443218009562 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218009563 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 443218009564 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218009565 phosphate binding site [ion binding]; other site 443218009566 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 443218009567 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218009568 active site 2 [active] 443218009569 active site 1 [active] 443218009570 Acyl transferase domain; Region: Acyl_transf_1; cl08282 443218009571 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443218009572 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 443218009573 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 443218009574 putative NAD(P) binding site [chemical binding]; other site 443218009575 active site 443218009576 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 443218009577 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 443218009578 active site 443218009579 Glucitol operon activator protein (GutM); Region: GutM; cl01890 443218009580 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 443218009581 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 443218009582 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443218009583 active site 443218009584 dimerization interface [polypeptide binding]; other site 443218009585 ribonuclease PH; Reviewed; Region: rph; PRK00173 443218009586 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443218009587 hexamer interface [polypeptide binding]; other site 443218009588 active site 443218009589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218009590 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218009591 Rhomboid family; Region: Rhomboid; cl11446 443218009592 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 443218009593 putative active site pocket [active] 443218009594 cleavage site 443218009595 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443218009596 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 443218009597 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443218009598 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443218009599 active site 443218009600 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 443218009601 Isochorismatase family; Region: Isochorismatase; pfam00857 443218009602 catalytic triad [active] 443218009603 metal binding site [ion binding]; metal-binding site 443218009604 conserved cis-peptide bond; other site 443218009605 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 443218009606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009607 DEAD_2; Region: DEAD_2; pfam06733 443218009608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009609 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 443218009610 dimer interface [polypeptide binding]; other site 443218009611 putative active site [active] 443218009612 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443218009613 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 443218009614 phosphoserine phosphatase SerB; Region: serB; TIGR00338 443218009615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218009616 motif II; other site 443218009617 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443218009618 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443218009619 D-pathway; other site 443218009620 Putative ubiquinol binding site [chemical binding]; other site 443218009621 Low-spin heme (heme b) binding site [chemical binding]; other site 443218009622 Putative water exit pathway; other site 443218009623 Binuclear center (heme o3/CuB) [ion binding]; other site 443218009624 K-pathway; other site 443218009625 Putative proton exit pathway; other site 443218009626 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443218009627 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443218009628 siderophore binding site; other site 443218009629 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 443218009630 NADP+ binding site [chemical binding]; other site 443218009631 folate binding site [chemical binding]; other site 443218009632 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 443218009633 dimerization interface [polypeptide binding]; other site 443218009634 active site 443218009635 Helix-turn-helix domains; Region: HTH; cl00088 443218009636 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218009637 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 443218009638 putative ligand binding site [chemical binding]; other site 443218009639 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 443218009640 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 443218009641 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443218009642 multimer interface [polypeptide binding]; other site 443218009643 active site 443218009644 catalytic triad [active] 443218009645 dimer interface [polypeptide binding]; other site 443218009646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218009647 Walker A motif; other site 443218009648 ATP binding site [chemical binding]; other site 443218009649 Walker B motif; other site 443218009650 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 443218009651 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 443218009652 nudix motif; other site 443218009653 Helix-turn-helix domains; Region: HTH; cl00088 443218009654 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 443218009655 putative dimerization interface [polypeptide binding]; other site 443218009656 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 443218009657 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 443218009658 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 443218009659 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 443218009660 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443218009661 dimer interface [polypeptide binding]; other site 443218009662 putative radical transfer pathway; other site 443218009663 diiron center [ion binding]; other site 443218009664 tyrosyl radical; other site 443218009665 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443218009666 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 443218009667 NAD binding site [chemical binding]; other site 443218009668 substrate binding site [chemical binding]; other site 443218009669 catalytic Zn binding site [ion binding]; other site 443218009670 tetramer interface [polypeptide binding]; other site 443218009671 structural Zn binding site [ion binding]; other site 443218009672 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443218009673 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218009674 Helix-turn-helix domains; Region: HTH; cl00088 443218009675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218009676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443218009677 RNA binding surface [nucleotide binding]; other site 443218009678 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 443218009679 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 443218009680 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443218009681 active site 443218009682 dimer interface [polypeptide binding]; other site 443218009683 catalytic residues [active] 443218009684 effector binding site; other site 443218009685 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 443218009686 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218009687 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218009688 catalytic residues [active] 443218009689 Helix-turn-helix domains; Region: HTH; cl00088 443218009690 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 443218009691 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218009692 Walker A/P-loop; other site 443218009693 ATP binding site [chemical binding]; other site 443218009694 Q-loop/lid; other site 443218009695 ABC transporter signature motif; other site 443218009696 Walker B; other site 443218009697 D-loop; other site 443218009698 H-loop/switch region; other site 443218009699 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 443218009700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 443218009701 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 443218009702 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218009703 Helix-turn-helix domains; Region: HTH; cl00088 443218009704 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218009705 Helix-turn-helix domains; Region: HTH; cl00088 443218009706 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 443218009707 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443218009708 homodimer interface [polypeptide binding]; other site 443218009709 NAD binding pocket [chemical binding]; other site 443218009710 ATP binding pocket [chemical binding]; other site 443218009711 Mg binding site [ion binding]; other site 443218009712 active-site loop [active] 443218009713 Vitamin K epoxide reductase family; Region: VKOR; cl01729 443218009714 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218009715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218009716 Restriction endonuclease NaeI; Region: NaeI; pfam09126 443218009717 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 443218009718 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 443218009719 cofactor binding site; other site 443218009720 DNA binding site [nucleotide binding] 443218009721 substrate interaction site [chemical binding]; other site 443218009722 Uncharacterized conserved protein [Function unknown]; Region: COG2966 443218009723 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 443218009724 short chain dehydrogenase; Validated; Region: PRK05855 443218009725 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 443218009726 additional DNA contacts [nucleotide binding]; other site 443218009727 active site 443218009728 zinc binding site [ion binding]; other site 443218009729 DNA intercalation site [nucleotide binding]; other site 443218009730 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443218009731 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 443218009732 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 443218009733 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218009734 NAD(P) binding site [chemical binding]; other site 443218009735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009736 S-adenosylmethionine binding site [chemical binding]; other site 443218009737 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 443218009738 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443218009739 active site 443218009740 catalytic site [active] 443218009741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443218009742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218009743 DNA binding site [nucleotide binding] 443218009744 domain linker motif; other site 443218009745 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443218009746 Helix-turn-helix domains; Region: HTH; cl00088 443218009747 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443218009748 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218009749 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443218009750 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443218009751 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443218009752 Dehydratase family; Region: ILVD_EDD; cl00340 443218009753 6-phosphogluconate dehydratase; Region: edd; TIGR01196 443218009754 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218009755 glucokinase, proteobacterial type; Region: glk; TIGR00749 443218009756 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 443218009757 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 443218009758 active site 443218009759 intersubunit interface [polypeptide binding]; other site 443218009760 catalytic residue [active] 443218009761 EamA-like transporter family; Region: EamA; cl01037 443218009762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218009763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218009764 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 443218009765 dimer interface [polypeptide binding]; other site 443218009766 ligand binding site [chemical binding]; other site 443218009767 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218009768 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218009769 RDD family; Region: RDD; cl00746 443218009770 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 443218009771 trehalose synthase; Region: treS_nterm; TIGR02456 443218009772 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443218009773 active site 443218009774 catalytic site [active] 443218009775 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 443218009776 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218009777 active site 2 [active] 443218009778 active site 1 [active] 443218009779 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218009780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009781 Helix-turn-helix domains; Region: HTH; cl00088 443218009782 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 443218009783 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 443218009784 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 443218009785 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 443218009786 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443218009787 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 443218009788 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218009789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218009790 S-adenosylmethionine binding site [chemical binding]; other site 443218009791 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 443218009792 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 443218009793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443218009794 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 443218009795 active site 443218009796 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218009797 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 443218009798 putative NAD(P) binding site [chemical binding]; other site 443218009799 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218009800 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 443218009801 Nucleoside recognition; Region: Gate; cl00486 443218009802 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 443218009803 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218009804 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443218009805 SmpB-tmRNA interface; other site 443218009806 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443218009807 FtsX-like permease family; Region: FtsX; cl15850 443218009808 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443218009809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009810 Walker A/P-loop; other site 443218009811 ATP binding site [chemical binding]; other site 443218009812 Q-loop/lid; other site 443218009813 ABC transporter signature motif; other site 443218009814 Walker B; other site 443218009815 D-loop; other site 443218009816 H-loop/switch region; other site 443218009817 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443218009818 RF-1 domain; Region: RF-1; cl02875 443218009819 RF-1 domain; Region: RF-1; cl02875 443218009820 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 443218009821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009822 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 443218009823 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 443218009824 active site 443218009825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218009826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009827 active site 443218009828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218009829 active site 443218009830 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 443218009831 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218009832 short chain dehydrogenase; Provisional; Region: PRK07825 443218009833 classical (c) SDRs; Region: SDR_c; cd05233 443218009834 NAD(P) binding site [chemical binding]; other site 443218009835 active site 443218009836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009837 Helix-turn-helix domains; Region: HTH; cl00088 443218009838 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 443218009839 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443218009840 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443218009841 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443218009842 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 443218009843 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 443218009844 Protein of unknown function DUF45; Region: DUF45; cl00636 443218009845 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 443218009846 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218009847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 443218009848 active site 443218009849 ATP binding site [chemical binding]; other site 443218009850 Transcription factor WhiB; Region: Whib; pfam02467 443218009851 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443218009852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009853 Family description; Region: UvrD_C_2; cl15862 443218009854 HRDC domain; Region: HRDC; cl02578 443218009855 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443218009856 catalytic residues [active] 443218009857 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 443218009858 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 443218009859 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443218009860 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443218009861 putative NADH binding site [chemical binding]; other site 443218009862 putative active site [active] 443218009863 nudix motif; other site 443218009864 putative metal binding site [ion binding]; other site 443218009865 Ion channel; Region: Ion_trans_2; cl11596 443218009866 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443218009867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218009868 Uncharacterized conserved protein [Function unknown]; Region: COG3268 443218009869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218009870 NAD(P) binding site [chemical binding]; other site 443218009871 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443218009872 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 443218009873 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443218009874 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443218009875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218009876 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 443218009877 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 443218009878 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 443218009879 peptide synthase; Provisional; Region: PRK12467 443218009880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218009881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218009882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218009883 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443218009884 active site 443218009885 DNA binding site [nucleotide binding] 443218009886 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 443218009887 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 443218009888 putative active site [active] 443218009889 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 443218009890 putative active site [active] 443218009891 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 443218009892 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443218009893 active site 443218009894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218009895 DNA binding site [nucleotide binding] 443218009896 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 443218009897 nitrite reductase subunit NirD; Provisional; Region: PRK14989 443218009898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218009899 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 443218009900 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 443218009901 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 443218009902 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 443218009903 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 443218009904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218009905 putative substrate translocation pore; other site 443218009906 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443218009907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218009908 DNA-binding site [nucleotide binding]; DNA binding site 443218009909 FCD domain; Region: FCD; cl11656 443218009910 TIGR02569 family protein; Region: TIGR02569_actnb 443218009911 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 443218009912 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443218009913 ATP binding site [chemical binding]; other site 443218009914 substrate interface [chemical binding]; other site 443218009915 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443218009916 active site residue [active] 443218009917 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 443218009918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218009919 Helix-turn-helix domains; Region: HTH; cl00088 443218009920 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 443218009921 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 443218009922 helicase 45; Provisional; Region: PTZ00424 443218009923 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443218009924 ATP binding site [chemical binding]; other site 443218009925 Mg++ binding site [ion binding]; other site 443218009926 motif III; other site 443218009927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009928 nucleotide binding region [chemical binding]; other site 443218009929 ATP-binding site [chemical binding]; other site 443218009930 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 443218009931 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218009932 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218009933 P-loop; other site 443218009934 Magnesium ion binding site [ion binding]; other site 443218009935 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218009936 Magnesium ion binding site [ion binding]; other site 443218009937 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443218009938 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 443218009939 Transcription factor WhiB; Region: Whib; pfam02467 443218009940 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443218009941 PAS fold; Region: PAS_4; pfam08448 443218009942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443218009943 Histidine kinase; Region: HisKA_2; cl06527 443218009944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218009945 ATP binding site [chemical binding]; other site 443218009946 Mg2+ binding site [ion binding]; other site 443218009947 G-X-G motif; other site 443218009948 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218009949 carboxyltransferase (CT) interaction site; other site 443218009950 biotinylation site [posttranslational modification]; other site 443218009951 Putative zinc-finger; Region: zf-HC2; cl15806 443218009952 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443218009953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218009954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218009955 DNA binding residues [nucleotide binding] 443218009956 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 443218009957 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443218009958 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 443218009959 hinge; other site 443218009960 active site 443218009961 Predicted GTPases [General function prediction only]; Region: COG1162 443218009962 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443218009963 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443218009964 GTP/Mg2+ binding site [chemical binding]; other site 443218009965 G4 box; other site 443218009966 G5 box; other site 443218009967 G1 box; other site 443218009968 Switch I region; other site 443218009969 G2 box; other site 443218009970 G3 box; other site 443218009971 Switch II region; other site 443218009972 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 443218009973 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218009974 putative di-iron ligands [ion binding]; other site 443218009975 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 443218009976 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218009977 FAD binding pocket [chemical binding]; other site 443218009978 FAD binding motif [chemical binding]; other site 443218009979 phosphate binding motif [ion binding]; other site 443218009980 beta-alpha-beta structure motif; other site 443218009981 NAD binding pocket [chemical binding]; other site 443218009982 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218009983 catalytic loop [active] 443218009984 iron binding site [ion binding]; other site 443218009985 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218009986 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218009987 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443218009988 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 443218009989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443218009990 nucleotide binding region [chemical binding]; other site 443218009991 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 443218009992 30S subunit binding site; other site 443218009993 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443218009994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 443218009995 lipoprotein LpqB; Provisional; Region: PRK13616 443218009996 Sporulation and spore germination; Region: Germane; cl11253 443218009997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218009998 dimer interface [polypeptide binding]; other site 443218009999 phosphorylation site [posttranslational modification] 443218010000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010001 ATP binding site [chemical binding]; other site 443218010002 Mg2+ binding site [ion binding]; other site 443218010003 G-X-G motif; other site 443218010004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218010005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010006 active site 443218010007 phosphorylation site [posttranslational modification] 443218010008 intermolecular recognition site; other site 443218010009 dimerization interface [polypeptide binding]; other site 443218010010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218010011 DNA binding site [nucleotide binding] 443218010012 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 443218010013 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443218010014 TMP-binding site; other site 443218010015 ATP-binding site [chemical binding]; other site 443218010016 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443218010017 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 443218010018 oligomerization interface [polypeptide binding]; other site 443218010019 active site 443218010020 NAD+ binding site [chemical binding]; other site 443218010021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010022 Helix-turn-helix domains; Region: HTH; cl00088 443218010023 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218010024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010025 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443218010026 Rubredoxin; Region: Rubredoxin; pfam00301 443218010027 iron binding site [ion binding]; other site 443218010028 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 443218010029 Rubredoxin; Region: Rubredoxin; pfam00301 443218010030 iron binding site [ion binding]; other site 443218010031 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 443218010032 Di-iron ligands [ion binding]; other site 443218010033 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 443218010034 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443218010035 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443218010036 active site 443218010037 substrate binding site [chemical binding]; other site 443218010038 metal binding site [ion binding]; metal-binding site 443218010039 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443218010040 Transcription factor WhiB; Region: Whib; pfam02467 443218010041 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 443218010042 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 443218010043 phosphate binding site [ion binding]; other site 443218010044 dimer interface [polypeptide binding]; other site 443218010045 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 443218010046 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 443218010047 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 443218010048 putative FMN binding site [chemical binding]; other site 443218010049 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 443218010050 nudix motif; other site 443218010051 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 443218010052 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 443218010053 active site 443218010054 Substrate binding site; other site 443218010055 Mg++ binding site; other site 443218010056 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443218010057 putative trimer interface [polypeptide binding]; other site 443218010058 putative CoA binding site [chemical binding]; other site 443218010059 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443218010060 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443218010061 Probable Catalytic site; other site 443218010062 metal-binding site 443218010063 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443218010064 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443218010065 NADP binding site [chemical binding]; other site 443218010066 active site 443218010067 putative substrate binding site [chemical binding]; other site 443218010068 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 443218010069 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443218010070 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010071 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 443218010072 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 443218010073 probable active site [active] 443218010074 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 443218010075 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 443218010076 active site residue [active] 443218010077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010079 active site 443218010080 phosphorylation site [posttranslational modification] 443218010081 intermolecular recognition site; other site 443218010082 dimerization interface [polypeptide binding]; other site 443218010083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010084 DNA binding residues [nucleotide binding] 443218010085 dimerization interface [polypeptide binding]; other site 443218010086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218010087 Histidine kinase; Region: HisKA_3; pfam07730 443218010088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218010089 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010090 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218010091 FAD binding site [chemical binding]; other site 443218010092 homotetramer interface [polypeptide binding]; other site 443218010093 substrate binding pocket [chemical binding]; other site 443218010094 catalytic base [active] 443218010095 AIR carboxylase; Region: AIRC; cl00310 443218010096 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 443218010097 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218010098 GtrA-like protein; Region: GtrA; cl00971 443218010099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218010100 dimer interface [polypeptide binding]; other site 443218010101 phosphorylation site [posttranslational modification] 443218010102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218010103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443218010104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010105 active site 443218010106 phosphorylation site [posttranslational modification] 443218010107 intermolecular recognition site; other site 443218010108 dimerization interface [polypeptide binding]; other site 443218010109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218010110 DNA binding site [nucleotide binding] 443218010111 Bacterial PH domain; Region: DUF304; cl01348 443218010112 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443218010113 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 443218010114 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443218010115 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218010116 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218010117 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218010118 Maf-like protein; Region: Maf; pfam02545 443218010119 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443218010120 active site 443218010121 dimer interface [polypeptide binding]; other site 443218010122 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218010123 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443218010124 intersubunit interface [polypeptide binding]; other site 443218010125 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443218010126 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443218010127 active site residue [active] 443218010128 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443218010129 active site residue [active] 443218010130 Fe-S metabolism associated domain; Region: SufE; cl00951 443218010131 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218010132 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218010133 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218010134 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218010135 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218010136 carboxyltransferase (CT) interaction site; other site 443218010137 biotinylation site [posttranslational modification]; other site 443218010138 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 443218010139 Secretory lipase; Region: LIP; pfam03583 443218010140 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218010141 glycerol kinase; Provisional; Region: glpK; PRK00047 443218010142 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 443218010143 N- and C-terminal domain interface [polypeptide binding]; other site 443218010144 putative active site [active] 443218010145 putative MgATP binding site [chemical binding]; other site 443218010146 catalytic site [active] 443218010147 metal binding site [ion binding]; metal-binding site 443218010148 putative homotetramer interface [polypeptide binding]; other site 443218010149 putative glycerol binding site [chemical binding]; other site 443218010150 homodimer interface [polypeptide binding]; other site 443218010151 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443218010152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010154 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218010155 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 443218010156 dimerization interface [polypeptide binding]; other site 443218010157 putative active site pocket [active] 443218010158 putative catalytic residue [active] 443218010159 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218010160 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 443218010161 Walker A/P-loop; other site 443218010162 ATP binding site [chemical binding]; other site 443218010163 Q-loop/lid; other site 443218010164 ABC transporter signature motif; other site 443218010165 Walker B; other site 443218010166 D-loop; other site 443218010167 H-loop/switch region; other site 443218010168 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 443218010169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218010170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218010171 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443218010172 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 443218010173 metal binding site [ion binding]; metal-binding site 443218010174 putative dimer interface [polypeptide binding]; other site 443218010175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218010176 substrate binding site [chemical binding]; other site 443218010177 oxyanion hole (OAH) forming residues; other site 443218010178 trimer interface [polypeptide binding]; other site 443218010179 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010180 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010181 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 443218010182 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010183 hypothetical protein; Provisional; Region: PRK14851 443218010184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218010185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010186 NAD(P) binding site [chemical binding]; other site 443218010187 active site 443218010188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010190 active site 443218010191 phosphorylation site [posttranslational modification] 443218010192 intermolecular recognition site; other site 443218010193 dimerization interface [polypeptide binding]; other site 443218010194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010195 DNA binding residues [nucleotide binding] 443218010196 dimerization interface [polypeptide binding]; other site 443218010197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218010198 Ligand Binding Site [chemical binding]; other site 443218010199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218010200 Ligand Binding Site [chemical binding]; other site 443218010201 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443218010202 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 443218010203 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443218010204 active site 443218010205 substrate binding site [chemical binding]; other site 443218010206 metal binding site [ion binding]; metal-binding site 443218010207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218010208 active site 443218010209 NlpC/P60 family; Region: NLPC_P60; cl11438 443218010210 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443218010211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218010212 active site 443218010213 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443218010214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010215 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218010216 Helix-turn-helix domains; Region: HTH; cl00088 443218010217 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218010218 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218010219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010220 dimer interface [polypeptide binding]; other site 443218010221 conserved gate region; other site 443218010222 putative PBP binding loops; other site 443218010223 ABC-ATPase subunit interface; other site 443218010224 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218010225 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 443218010226 Walker A/P-loop; other site 443218010227 ATP binding site [chemical binding]; other site 443218010228 Q-loop/lid; other site 443218010229 ABC transporter signature motif; other site 443218010230 Walker B; other site 443218010231 D-loop; other site 443218010232 H-loop/switch region; other site 443218010233 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 443218010234 NMT1-like family; Region: NMT1_2; cl15260 443218010235 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 443218010236 Helix-turn-helix domains; Region: HTH; cl00088 443218010237 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443218010238 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443218010239 substrate binding site [chemical binding]; other site 443218010240 ligand binding site [chemical binding]; other site 443218010241 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443218010242 substrate binding site [chemical binding]; other site 443218010243 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 443218010244 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 443218010245 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 443218010246 dimer interface [polypeptide binding]; other site 443218010247 PYR/PP interface [polypeptide binding]; other site 443218010248 TPP binding site [chemical binding]; other site 443218010249 substrate binding site [chemical binding]; other site 443218010250 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 443218010251 TPP-binding site; other site 443218010252 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 443218010253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010254 H-loop/switch region; other site 443218010255 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 443218010256 NMT1-like family; Region: NMT1_2; cl15260 443218010257 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 443218010258 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 443218010259 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443218010260 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 443218010261 active site 443218010262 non-prolyl cis peptide bond; other site 443218010263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010264 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443218010265 active site 443218010266 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 443218010267 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443218010268 active site 443218010269 non-prolyl cis peptide bond; other site 443218010270 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443218010271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010272 dimer interface [polypeptide binding]; other site 443218010273 conserved gate region; other site 443218010274 putative PBP binding loops; other site 443218010275 ABC-ATPase subunit interface; other site 443218010276 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 443218010277 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 443218010278 Walker A/P-loop; other site 443218010279 ATP binding site [chemical binding]; other site 443218010280 Q-loop/lid; other site 443218010281 ABC transporter signature motif; other site 443218010282 Walker B; other site 443218010283 D-loop; other site 443218010284 H-loop/switch region; other site 443218010285 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 443218010286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443218010287 membrane-bound complex binding site; other site 443218010288 Helix-turn-helix domains; Region: HTH; cl00088 443218010289 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218010290 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 443218010291 Helix-turn-helix domains; Region: HTH; cl00088 443218010292 Protein of unknown function (DUF998); Region: DUF998; pfam06197 443218010293 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 443218010294 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218010295 Walker A/P-loop; other site 443218010296 ATP binding site [chemical binding]; other site 443218010297 Q-loop/lid; other site 443218010298 ABC transporter signature motif; other site 443218010299 Walker B; other site 443218010300 D-loop; other site 443218010301 H-loop/switch region; other site 443218010302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218010303 Histidine kinase; Region: HisKA_3; pfam07730 443218010304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010305 ATP binding site [chemical binding]; other site 443218010306 Mg2+ binding site [ion binding]; other site 443218010307 G-X-G motif; other site 443218010308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010310 active site 443218010311 phosphorylation site [posttranslational modification] 443218010312 intermolecular recognition site; other site 443218010313 dimerization interface [polypeptide binding]; other site 443218010314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010315 DNA binding residues [nucleotide binding] 443218010316 dimerization interface [polypeptide binding]; other site 443218010317 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443218010318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010319 Flavin Reductases; Region: FlaRed; cl00801 443218010320 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 443218010321 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 443218010322 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 443218010323 active site 443218010324 dimer interface [polypeptide binding]; other site 443218010325 non-prolyl cis peptide bond; other site 443218010326 insertion regions; other site 443218010327 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443218010328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010329 active site 443218010330 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 443218010331 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 443218010332 active site 443218010333 dimer interface [polypeptide binding]; other site 443218010334 non-prolyl cis peptide bond; other site 443218010335 insertion regions; other site 443218010336 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443218010337 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443218010338 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443218010339 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 443218010340 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443218010341 active site 443218010342 catalytic motif [active] 443218010343 Zn binding site [ion binding]; other site 443218010344 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443218010345 putative Iron-sulfur protein interface [polypeptide binding]; other site 443218010346 putative proximal heme binding site [chemical binding]; other site 443218010347 putative SdhD-like interface [polypeptide binding]; other site 443218010348 putative distal heme binding site [chemical binding]; other site 443218010349 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443218010350 putative Iron-sulfur protein interface [polypeptide binding]; other site 443218010351 putative proximal heme binding site [chemical binding]; other site 443218010352 putative SdhC-like subunit interface [polypeptide binding]; other site 443218010353 putative distal heme binding site [chemical binding]; other site 443218010354 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443218010355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010356 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443218010357 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443218010358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 443218010359 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 443218010360 nudix motif; other site 443218010361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443218010362 DNA binding site [nucleotide binding] 443218010363 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 443218010364 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 443218010365 putative ligand binding site [chemical binding]; other site 443218010366 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218010367 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218010368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010370 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 443218010371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010372 Helix-turn-helix domains; Region: HTH; cl00088 443218010373 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218010374 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443218010375 catalytic triad [active] 443218010376 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218010377 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010378 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 443218010379 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 443218010380 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218010381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010382 NAD(P) binding site [chemical binding]; other site 443218010383 active site 443218010384 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218010385 classical (c) SDRs; Region: SDR_c; cd05233 443218010386 NAD(P) binding site [chemical binding]; other site 443218010387 active site 443218010388 Helix-turn-helix domains; Region: HTH; cl00088 443218010389 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 443218010390 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443218010391 FAD binding domain; Region: FAD_binding_4; pfam01565 443218010392 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 443218010393 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 443218010394 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 443218010395 dimer interface [polypeptide binding]; other site 443218010396 active site 443218010397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218010398 substrate binding site [chemical binding]; other site 443218010399 catalytic residue [active] 443218010400 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 443218010401 putative FMN binding site [chemical binding]; other site 443218010402 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218010403 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443218010404 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 443218010405 Walker A/P-loop; other site 443218010406 ATP binding site [chemical binding]; other site 443218010407 Q-loop/lid; other site 443218010408 ABC transporter signature motif; other site 443218010409 Walker B; other site 443218010410 D-loop; other site 443218010411 H-loop/switch region; other site 443218010412 multicopper oxidase; Provisional; Region: PRK10965 443218010413 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218010414 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 443218010415 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 443218010416 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443218010417 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443218010418 FAD binding pocket [chemical binding]; other site 443218010419 FAD binding motif [chemical binding]; other site 443218010420 phosphate binding motif [ion binding]; other site 443218010421 NAD binding pocket [chemical binding]; other site 443218010422 Secretory lipase; Region: LIP; pfam03583 443218010423 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218010424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443218010425 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 443218010426 Walker A/P-loop; other site 443218010427 ATP binding site [chemical binding]; other site 443218010428 Q-loop/lid; other site 443218010429 ABC transporter signature motif; other site 443218010430 Walker B; other site 443218010431 D-loop; other site 443218010432 H-loop/switch region; other site 443218010433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443218010434 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 443218010435 Walker A/P-loop; other site 443218010436 ATP binding site [chemical binding]; other site 443218010437 Q-loop/lid; other site 443218010438 ABC transporter signature motif; other site 443218010439 Walker B; other site 443218010440 D-loop; other site 443218010441 H-loop/switch region; other site 443218010442 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443218010443 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010444 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443218010445 TM-ABC transporter signature motif; other site 443218010446 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443218010447 TM-ABC transporter signature motif; other site 443218010448 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 443218010449 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 443218010450 ligand binding site [chemical binding]; other site 443218010451 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443218010452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010453 Walker A/P-loop; other site 443218010454 ATP binding site [chemical binding]; other site 443218010455 Q-loop/lid; other site 443218010456 ABC transporter signature motif; other site 443218010457 Walker B; other site 443218010458 D-loop; other site 443218010459 H-loop/switch region; other site 443218010460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443218010461 TM-ABC transporter signature motif; other site 443218010462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 443218010463 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 443218010464 putative ligand binding site [chemical binding]; other site 443218010465 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443218010466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443218010467 DNA-binding site [nucleotide binding]; DNA binding site 443218010468 UTRA domain; Region: UTRA; cl01230 443218010469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443218010470 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 443218010471 substrate binding site [chemical binding]; other site 443218010472 ATP binding site [chemical binding]; other site 443218010473 KduI/IolB family; Region: KduI; cl01508 443218010474 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 443218010475 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443218010476 PYR/PP interface [polypeptide binding]; other site 443218010477 dimer interface [polypeptide binding]; other site 443218010478 TPP binding site [chemical binding]; other site 443218010479 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 443218010480 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 443218010481 TPP-binding site; other site 443218010482 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218010483 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443218010484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218010485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 443218010487 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443218010488 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443218010489 Metal-binding active site; metal-binding site 443218010490 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443218010491 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218010492 tetrameric interface [polypeptide binding]; other site 443218010493 NAD binding site [chemical binding]; other site 443218010494 catalytic residues [active] 443218010495 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443218010496 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443218010497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010498 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 443218010499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010500 Helix-turn-helix domains; Region: HTH; cl00088 443218010501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010502 Helix-turn-helix domains; Region: HTH; cl00088 443218010503 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 443218010504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218010505 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 443218010506 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443218010507 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443218010508 active site 443218010509 HIGH motif; other site 443218010510 dimer interface [polypeptide binding]; other site 443218010511 KMSKS motif; other site 443218010512 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 443218010513 putative active site [active] 443218010514 putative catalytic site [active] 443218010515 putative DNA binding site [nucleotide binding]; other site 443218010516 putative phosphate binding site [ion binding]; other site 443218010517 metal binding site A [ion binding]; metal-binding site 443218010518 putative AP binding site [nucleotide binding]; other site 443218010519 putative metal binding site B [ion binding]; other site 443218010520 MFS transport protein AraJ; Provisional; Region: PRK10091 443218010521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218010522 putative substrate translocation pore; other site 443218010523 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 443218010524 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443218010525 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443218010526 homodimer interface [polypeptide binding]; other site 443218010527 substrate-cofactor binding pocket; other site 443218010528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218010529 catalytic residue [active] 443218010530 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010531 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 443218010532 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 443218010533 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443218010534 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443218010535 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443218010536 homodimer interface [polypeptide binding]; other site 443218010537 NADP binding site [chemical binding]; other site 443218010538 substrate binding site [chemical binding]; other site 443218010539 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218010540 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 443218010541 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 443218010542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010543 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010545 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 443218010546 active site 443218010547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218010548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218010549 active site 443218010550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010551 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218010552 NAD(P) binding site [chemical binding]; other site 443218010553 active site 443218010554 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443218010555 active site 443218010556 catalytic site [active] 443218010557 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218010558 active site 2 [active] 443218010559 active site 1 [active] 443218010560 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443218010561 hydrophobic ligand binding site; other site 443218010562 lipid-transfer protein; Provisional; Region: PRK08256 443218010563 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 443218010564 active site 443218010565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010566 Helix-turn-helix domains; Region: HTH; cl00088 443218010567 enoyl-CoA hydratase; Provisional; Region: PRK09245 443218010568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218010569 substrate binding site [chemical binding]; other site 443218010570 oxyanion hole (OAH) forming residues; other site 443218010571 trimer interface [polypeptide binding]; other site 443218010572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443218010575 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 443218010576 active site 443218010577 catalytic tetrad [active] 443218010578 cyclase homology domain; Region: CHD; cd07302 443218010579 nucleotidyl binding site; other site 443218010580 metal binding site [ion binding]; metal-binding site 443218010581 dimer interface [polypeptide binding]; other site 443218010582 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010583 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010584 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 443218010585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218010586 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 443218010587 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 443218010588 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443218010589 generic binding surface II; other site 443218010590 generic binding surface I; other site 443218010591 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443218010592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218010593 DNA binding residues [nucleotide binding] 443218010594 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443218010595 putative dimer interface [polypeptide binding]; other site 443218010596 short chain dehydrogenase; Validated; Region: PRK05855 443218010597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010598 DNA Polymerase Y-family; Region: PolY_like; cd03468 443218010599 active site 443218010600 DNA binding site [nucleotide binding] 443218010601 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443218010602 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443218010603 active site 443218010604 ATP binding site [chemical binding]; other site 443218010605 substrate binding site [chemical binding]; other site 443218010606 activation loop (A-loop); other site 443218010607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218010608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218010609 active site 443218010610 phosphorylation site [posttranslational modification] 443218010611 intermolecular recognition site; other site 443218010612 dimerization interface [polypeptide binding]; other site 443218010613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010614 DNA binding residues [nucleotide binding] 443218010615 dimerization interface [polypeptide binding]; other site 443218010616 PspC domain; Region: PspC; cl00864 443218010617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218010618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218010619 ATP binding site [chemical binding]; other site 443218010620 Mg2+ binding site [ion binding]; other site 443218010621 G-X-G motif; other site 443218010622 PspC domain; Region: PspC; cl00864 443218010623 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 443218010624 GMP synthase; Reviewed; Region: guaA; PRK00074 443218010625 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443218010626 AMP/PPi binding site [chemical binding]; other site 443218010627 candidate oxyanion hole; other site 443218010628 catalytic triad [active] 443218010629 potential glutamine specificity residues [chemical binding]; other site 443218010630 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443218010631 ATP Binding subdomain [chemical binding]; other site 443218010632 Ligand Binding sites [chemical binding]; other site 443218010633 Dimerization subdomain; other site 443218010634 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 443218010635 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443218010636 Sodium:solute symporter family; Region: SSF; cl00456 443218010637 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218010638 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443218010639 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443218010640 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 443218010641 active site 443218010642 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443218010643 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218010644 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 443218010645 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 443218010646 active site 443218010647 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 443218010648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218010649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218010650 DNA binding residues [nucleotide binding] 443218010651 Transcription factor WhiB; Region: Whib; pfam02467 443218010652 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443218010653 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443218010654 ring oligomerisation interface [polypeptide binding]; other site 443218010655 ATP/Mg binding site [chemical binding]; other site 443218010656 stacking interactions; other site 443218010657 hinge regions; other site 443218010658 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443218010659 oligomerisation interface [polypeptide binding]; other site 443218010660 mobile loop; other site 443218010661 roof hairpin; other site 443218010662 UGMP family protein; Validated; Region: PRK09604 443218010663 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443218010664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218010665 Coenzyme A binding pocket [chemical binding]; other site 443218010666 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 443218010667 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 443218010668 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218010670 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010671 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010672 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443218010673 alanine racemase; Reviewed; Region: alr; PRK00053 443218010674 active site 443218010675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218010676 dimer interface [polypeptide binding]; other site 443218010677 substrate binding site [chemical binding]; other site 443218010678 catalytic residues [active] 443218010679 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 443218010680 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443218010681 putative substrate binding site [chemical binding]; other site 443218010682 putative ATP binding site [chemical binding]; other site 443218010683 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443218010684 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443218010685 glutaminase active site [active] 443218010686 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443218010687 dimer interface [polypeptide binding]; other site 443218010688 active site 443218010689 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443218010690 dimer interface [polypeptide binding]; other site 443218010691 active site 443218010692 chlorophyllase; Region: PLN00021 443218010693 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 443218010694 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443218010695 active site 443218010696 substrate binding site [chemical binding]; other site 443218010697 metal binding site [ion binding]; metal-binding site 443218010698 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 443218010699 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443218010700 23S rRNA interface [nucleotide binding]; other site 443218010701 L3 interface [polypeptide binding]; other site 443218010702 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443218010703 Proteins of 100 residues with WXG; Region: WXG100; cl02005 443218010704 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 443218010705 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 443218010706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010707 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 443218010708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010710 Ubiquitin-like proteins; Region: UBQ; cl00155 443218010711 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 443218010712 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443218010713 active site 443218010714 catalytic residues [active] 443218010715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010716 Helix-turn-helix domains; Region: HTH; cl00088 443218010717 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443218010718 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 443218010719 active site 443218010720 intersubunit interface [polypeptide binding]; other site 443218010721 zinc binding site [ion binding]; other site 443218010722 Na+ binding site [ion binding]; other site 443218010723 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 443218010724 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 443218010725 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 443218010726 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218010727 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443218010728 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443218010729 putative acyl-acceptor binding pocket; other site 443218010730 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 443218010731 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 443218010732 putative acyl-acceptor binding pocket; other site 443218010733 YibE/F-like protein; Region: YibE_F; cl02259 443218010734 Vitamin K epoxide reductase family; Region: VKOR; cl01729 443218010735 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443218010736 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443218010737 enoyl-CoA hydratase; Provisional; Region: PRK07509 443218010738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218010739 substrate binding site [chemical binding]; other site 443218010740 oxyanion hole (OAH) forming residues; other site 443218010741 trimer interface [polypeptide binding]; other site 443218010742 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218010743 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 443218010744 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010745 peptide synthase; Validated; Region: PRK05691 443218010746 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010747 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218010748 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010749 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010750 peptide synthase; Provisional; Region: PRK12467 443218010751 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218010752 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010753 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010754 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218010755 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010756 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010757 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218010758 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010759 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010760 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218010761 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218010762 AMP-binding enzyme; Region: AMP-binding; cl15778 443218010763 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218010764 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 443218010765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443218010766 active site 443218010767 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218010768 classical (c) SDRs; Region: SDR_c; cd05233 443218010769 NAD(P) binding site [chemical binding]; other site 443218010770 active site 443218010771 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 443218010772 Clp amino terminal domain; Region: Clp_N; pfam02861 443218010773 Clp amino terminal domain; Region: Clp_N; pfam02861 443218010774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218010775 Walker A motif; other site 443218010776 ATP binding site [chemical binding]; other site 443218010777 Walker B motif; other site 443218010778 arginine finger; other site 443218010779 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 443218010780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218010781 Walker A motif; other site 443218010782 ATP binding site [chemical binding]; other site 443218010783 Walker B motif; other site 443218010784 arginine finger; other site 443218010785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 443218010786 Helix-turn-helix domains; Region: HTH; cl00088 443218010787 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 443218010788 DNA binding residues [nucleotide binding] 443218010789 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218010790 putative dimer interface [polypeptide binding]; other site 443218010791 chaperone protein DnaJ; Provisional; Region: PRK14279 443218010792 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443218010793 HSP70 interaction site [polypeptide binding]; other site 443218010794 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443218010795 Zn binding sites [ion binding]; other site 443218010796 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443218010797 dimer interface [polypeptide binding]; other site 443218010798 heat shock protein GrpE; Provisional; Region: PRK14140 443218010799 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443218010800 dimer interface [polypeptide binding]; other site 443218010801 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443218010802 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443218010803 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010804 Dynamin family; Region: Dynamin_N; pfam00350 443218010805 G1 box; other site 443218010806 GTP/Mg2+ binding site [chemical binding]; other site 443218010807 G2 box; other site 443218010808 Switch I region; other site 443218010809 G3 box; other site 443218010810 Switch II region; other site 443218010811 G4 box; other site 443218010812 G5 box; other site 443218010813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010814 Dynamin family; Region: Dynamin_N; pfam00350 443218010815 G1 box; other site 443218010816 GTP/Mg2+ binding site [chemical binding]; other site 443218010817 G2 box; other site 443218010818 Switch I region; other site 443218010819 G3 box; other site 443218010820 Switch II region; other site 443218010821 G4 box; other site 443218010822 G5 box; other site 443218010823 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443218010824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010825 Walker A motif; other site 443218010826 ATP binding site [chemical binding]; other site 443218010827 Walker B motif; other site 443218010828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218010829 DNA binding residues [nucleotide binding] 443218010830 dimerization interface [polypeptide binding]; other site 443218010831 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443218010832 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 443218010833 Cysteine-rich domain; Region: CCG; pfam02754 443218010834 Cysteine-rich domain; Region: CCG; pfam02754 443218010835 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443218010836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443218010837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218010838 homodimer interface [polypeptide binding]; other site 443218010839 catalytic residue [active] 443218010840 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 443218010841 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443218010842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010843 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443218010844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010845 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218010846 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 443218010847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218010848 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 443218010849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218010850 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443218010851 trimer interface [polypeptide binding]; other site 443218010852 active site 443218010853 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 443218010854 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 443218010855 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 443218010856 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 443218010857 FAD binding site [chemical binding]; other site 443218010858 substrate binding site [chemical binding]; other site 443218010859 catalytic residues [active] 443218010860 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 443218010861 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 443218010862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218010863 Walker A/P-loop; other site 443218010864 ATP binding site [chemical binding]; other site 443218010865 Q-loop/lid; other site 443218010866 ABC transporter signature motif; other site 443218010867 Walker B; other site 443218010868 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443218010869 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218010870 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218010871 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218010872 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 443218010873 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 443218010874 NADP binding site [chemical binding]; other site 443218010875 dimer interface [polypeptide binding]; other site 443218010876 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 443218010877 VanW like protein; Region: VanW; pfam04294 443218010878 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 443218010879 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443218010880 dimer interface [polypeptide binding]; other site 443218010881 active site 443218010882 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 443218010883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010884 NAD(P) binding site [chemical binding]; other site 443218010885 active site 443218010886 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218010887 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218010888 active site 2 [active] 443218010889 active site 1 [active] 443218010890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218010891 Helix-turn-helix domains; Region: HTH; cl00088 443218010892 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443218010893 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443218010894 Ligand Binding Site [chemical binding]; other site 443218010895 isochorismate synthase DhbC; Validated; Region: PRK06923 443218010896 chorismate binding enzyme; Region: Chorismate_bind; cl10555 443218010897 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 443218010898 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 443218010899 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 443218010900 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 443218010901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010902 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218010903 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443218010904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218010905 S-adenosylmethionine binding site [chemical binding]; other site 443218010906 Dodecin; Region: Dodecin; cl01328 443218010907 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443218010908 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443218010909 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 443218010910 active site 443218010911 substrate-binding site [chemical binding]; other site 443218010912 metal-binding site [ion binding] 443218010913 GTP binding site [chemical binding]; other site 443218010914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218010915 LabA_like proteins; Region: LabA_like; cd06167 443218010916 putative metal binding site [ion binding]; other site 443218010917 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443218010918 CrcB-like protein; Region: CRCB; cl09114 443218010919 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 443218010920 CrcB-like protein; Region: CRCB; cl09114 443218010921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 443218010922 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218010923 cyclase homology domain; Region: CHD; cd07302 443218010924 nucleotidyl binding site; other site 443218010925 metal binding site [ion binding]; metal-binding site 443218010926 dimer interface [polypeptide binding]; other site 443218010927 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 443218010928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218010929 dimerization interface [polypeptide binding]; other site 443218010930 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218010931 cyclase homology domain; Region: CHD; cd07302 443218010932 nucleotidyl binding site; other site 443218010933 metal binding site [ion binding]; metal-binding site 443218010934 dimer interface [polypeptide binding]; other site 443218010935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443218010936 dimerization interface [polypeptide binding]; other site 443218010937 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218010938 cyclase homology domain; Region: CHD; cd07302 443218010939 nucleotidyl binding site; other site 443218010940 metal binding site [ion binding]; metal-binding site 443218010941 dimer interface [polypeptide binding]; other site 443218010942 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443218010943 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443218010944 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 443218010945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218010946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218010947 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443218010948 Cupin domain; Region: Cupin_2; cl09118 443218010949 Pirin-related protein [General function prediction only]; Region: COG1741 443218010950 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443218010951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218010952 S-adenosylmethionine binding site [chemical binding]; other site 443218010953 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 443218010954 catalytic residues [active] 443218010955 catalytic nucleophile [active] 443218010956 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 443218010957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 443218010958 Probable transposase; Region: OrfB_IS605; pfam01385 443218010959 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 443218010960 mercuric reductase; Validated; Region: PRK06370 443218010961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218010962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218010963 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443218010964 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218010965 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218010966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218010967 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218010968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443218010969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218010970 putative PBP binding loops; other site 443218010971 ABC-ATPase subunit interface; other site 443218010972 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443218010973 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 443218010974 Walker A/P-loop; other site 443218010975 ATP binding site [chemical binding]; other site 443218010976 Q-loop/lid; other site 443218010977 ABC transporter signature motif; other site 443218010978 Walker B; other site 443218010979 D-loop; other site 443218010980 H-loop/switch region; other site 443218010981 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 443218010982 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 443218010983 dimer interface [polypeptide binding]; other site 443218010984 active site 443218010985 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443218010986 catalytic residues [active] 443218010987 substrate binding site [chemical binding]; other site 443218010988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218010989 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 443218010990 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443218010991 dimer interface [polypeptide binding]; other site 443218010992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218010993 catalytic residue [active] 443218010994 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443218010995 ATPase involved in DNA repair; Region: DUF3686; pfam12458 443218010996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218010997 Walker A motif; other site 443218010998 ATP binding site [chemical binding]; other site 443218010999 Walker B motif; other site 443218011000 arginine finger; other site 443218011001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 443218011002 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 443218011003 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 443218011004 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443218011005 active site 443218011006 Zn binding site [ion binding]; other site 443218011007 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 443218011008 OpgC protein; Region: OpgC_C; cl00792 443218011009 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443218011010 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 443218011011 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 443218011012 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011013 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218011014 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 443218011015 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 443218011016 active site 443218011017 DNA binding site [nucleotide binding] 443218011018 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 443218011019 DNA binding site [nucleotide binding] 443218011020 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218011021 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443218011022 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443218011023 nucleotide binding site [chemical binding]; other site 443218011024 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 443218011025 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443218011026 active site 443218011027 DNA binding site [nucleotide binding] 443218011028 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443218011029 DNA binding site [nucleotide binding] 443218011030 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443218011031 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443218011032 putative DNA binding site [nucleotide binding]; other site 443218011033 putative homodimer interface [polypeptide binding]; other site 443218011034 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218011035 allantoicase; Provisional; Region: PRK13257 443218011036 Allantoicase repeat; Region: Allantoicase; pfam03561 443218011037 Allantoicase repeat; Region: Allantoicase; pfam03561 443218011038 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 443218011039 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 443218011040 active site 443218011041 catalytic site [active] 443218011042 tetramer interface [polypeptide binding]; other site 443218011043 Sodium:solute symporter family; Region: SSF; cl00456 443218011044 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 443218011045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218011046 dimerization interface [polypeptide binding]; other site 443218011047 putative DNA binding site [nucleotide binding]; other site 443218011048 putative Zn2+ binding site [ion binding]; other site 443218011049 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 443218011050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218011051 putative metal binding site [ion binding]; other site 443218011052 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 443218011053 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443218011054 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 443218011055 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 443218011056 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443218011057 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 443218011058 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 443218011059 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 443218011060 active site 443218011061 putative substrate binding pocket [chemical binding]; other site 443218011062 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 443218011063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218011064 short chain dehydrogenase; Provisional; Region: PRK05872 443218011065 classical (c) SDRs; Region: SDR_c; cd05233 443218011066 NAD(P) binding site [chemical binding]; other site 443218011067 active site 443218011068 guanine deaminase; Region: guan_deamin; TIGR02967 443218011069 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443218011070 active site 443218011071 urate oxidase; Region: urate_oxi; TIGR03383 443218011072 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 443218011073 active site 443218011074 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 443218011075 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443218011076 Ligand binding site; other site 443218011077 metal-binding site 443218011078 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 443218011079 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218011080 DNA binding residues [nucleotide binding] 443218011081 drug binding residues [chemical binding]; other site 443218011082 dimer interface [polypeptide binding]; other site 443218011083 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940 443218011084 beta-clamp/clamp loader binding surface; other site 443218011085 beta-clamp/translesion DNA polymerase binding surface; other site 443218011086 Domain of unknown function (DUF222); Region: DUF222; pfam02720 443218011087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 443218011088 active site 443218011089 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011091 short chain dehydrogenase; Provisional; Region: PRK06914 443218011092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011093 NAD(P) binding site [chemical binding]; other site 443218011094 active site 443218011095 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 443218011096 NmrA-like family; Region: NmrA; pfam05368 443218011097 NADP binding site [chemical binding]; other site 443218011098 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011100 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218011101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011102 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 443218011103 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443218011104 tetramer interface [polypeptide binding]; other site 443218011105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218011106 catalytic residue [active] 443218011107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218011108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218011109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218011110 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218011111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218011112 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 443218011113 nucleotide binding site [chemical binding]; other site 443218011114 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 443218011115 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443218011116 intersubunit interface [polypeptide binding]; other site 443218011117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218011118 ABC-ATPase subunit interface; other site 443218011119 dimer interface [polypeptide binding]; other site 443218011120 putative PBP binding regions; other site 443218011121 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 443218011122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443218011123 ABC-ATPase subunit interface; other site 443218011124 dimer interface [polypeptide binding]; other site 443218011125 putative PBP binding regions; other site 443218011126 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443218011127 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443218011128 Walker A/P-loop; other site 443218011129 ATP binding site [chemical binding]; other site 443218011130 Q-loop/lid; other site 443218011131 ABC transporter signature motif; other site 443218011132 Walker B; other site 443218011133 D-loop; other site 443218011134 H-loop/switch region; other site 443218011135 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 443218011136 dimer interface [polypeptide binding]; other site 443218011137 [2Fe-2S] cluster binding site [ion binding]; other site 443218011138 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 443218011139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218011140 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443218011141 lipoyl synthase; Provisional; Region: PRK05481 443218011142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218011143 FeS/SAM binding site; other site 443218011144 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 443218011145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011146 acetoin reductases; Region: 23BDH; TIGR02415 443218011147 NAD(P) binding site [chemical binding]; other site 443218011148 active site 443218011149 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 443218011150 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 443218011151 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443218011152 tetramer interface [polypeptide binding]; other site 443218011153 TPP-binding site [chemical binding]; other site 443218011154 heterodimer interface [polypeptide binding]; other site 443218011155 phosphorylation loop region [posttranslational modification] 443218011156 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443218011157 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443218011158 alpha subunit interface [polypeptide binding]; other site 443218011159 TPP binding site [chemical binding]; other site 443218011160 heterodimer interface [polypeptide binding]; other site 443218011161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443218011162 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 443218011163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443218011164 E3 interaction surface; other site 443218011165 lipoyl attachment site [posttranslational modification]; other site 443218011166 GAF domain; Region: GAF; cl15785 443218011167 Helix-turn-helix domains; Region: HTH; cl00088 443218011168 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 443218011169 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 443218011170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011171 Helix-turn-helix domains; Region: HTH; cl00088 443218011172 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 443218011173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443218011174 NAD binding site [chemical binding]; other site 443218011175 homodimer interface [polypeptide binding]; other site 443218011176 homotetramer interface [polypeptide binding]; other site 443218011177 active site 443218011178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011179 S-adenosylmethionine binding site [chemical binding]; other site 443218011180 Protein of unknown function (DUF779); Region: DUF779; cl01432 443218011181 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 443218011182 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443218011183 NAD(P) binding site [chemical binding]; other site 443218011184 catalytic residues [active] 443218011185 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 443218011186 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218011187 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 443218011188 putative NAD(P) binding site [chemical binding]; other site 443218011189 catalytic Zn binding site [ion binding]; other site 443218011190 Helix-turn-helix domains; Region: HTH; cl00088 443218011191 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443218011192 Predicted membrane protein [Function unknown]; Region: COG1511 443218011193 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 443218011194 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218011195 Helix-turn-helix domains; Region: HTH; cl00088 443218011196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011197 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218011198 Walker A/P-loop; other site 443218011199 ATP binding site [chemical binding]; other site 443218011200 Q-loop/lid; other site 443218011201 ABC transporter signature motif; other site 443218011202 Walker B; other site 443218011203 D-loop; other site 443218011204 H-loop/switch region; other site 443218011205 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218011206 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443218011207 Amidase; Region: Amidase; cl11426 443218011208 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 443218011209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218011210 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218011211 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218011212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218011213 carboxyltransferase (CT) interaction site; other site 443218011214 biotinylation site [posttranslational modification]; other site 443218011215 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 443218011216 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443218011217 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443218011218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011219 active site 443218011220 phosphorylation site [posttranslational modification] 443218011221 intermolecular recognition site; other site 443218011222 dimerization interface [polypeptide binding]; other site 443218011223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443218011224 DNA binding site [nucleotide binding] 443218011225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443218011226 phosphorylation site [posttranslational modification] 443218011227 dimer interface [polypeptide binding]; other site 443218011228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218011229 ATP binding site [chemical binding]; other site 443218011230 Mg2+ binding site [ion binding]; other site 443218011231 G-X-G motif; other site 443218011232 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 443218011233 Cation transport protein; Region: TrkH; cl10514 443218011234 Ion transport protein; Region: Ion_trans; pfam00520 443218011235 Polycystin cation channel; Region: PKD_channel; pfam08016 443218011236 hypothetical protein; Provisional; Region: PRK07907 443218011237 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 443218011238 metal binding site [ion binding]; metal-binding site 443218011239 putative dimer interface [polypeptide binding]; other site 443218011240 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443218011241 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 443218011242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218011243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218011244 catalytic residue [active] 443218011245 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 443218011246 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443218011247 NAD(P) binding site [chemical binding]; other site 443218011248 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 443218011249 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 443218011250 active site 443218011251 zinc binding site [ion binding]; other site 443218011252 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 443218011253 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 443218011254 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 443218011255 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218011256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011257 Walker A/P-loop; other site 443218011258 ATP binding site [chemical binding]; other site 443218011259 Q-loop/lid; other site 443218011260 ABC transporter signature motif; other site 443218011261 Walker B; other site 443218011262 D-loop; other site 443218011263 H-loop/switch region; other site 443218011264 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 443218011265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011266 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 443218011267 Walker A/P-loop; other site 443218011268 ATP binding site [chemical binding]; other site 443218011269 Q-loop/lid; other site 443218011270 ABC transporter signature motif; other site 443218011271 Walker B; other site 443218011272 D-loop; other site 443218011273 H-loop/switch region; other site 443218011274 Peptidase family M23; Region: Peptidase_M23; pfam01551 443218011275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 443218011276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443218011277 catalytic residue [active] 443218011278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011279 Walker A motif; other site 443218011280 ATP binding site [chemical binding]; other site 443218011281 Walker B motif; other site 443218011282 TrwC relaxase; Region: TrwC; pfam08751 443218011283 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443218011284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011285 Family description; Region: UvrD_C_2; cl15862 443218011286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443218011287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218011288 non-specific DNA binding site [nucleotide binding]; other site 443218011289 salt bridge; other site 443218011290 sequence-specific DNA binding site [nucleotide binding]; other site 443218011291 Domain of unknown function (DUF955); Region: DUF955; cl01076 443218011292 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 443218011293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011294 Family description; Region: UvrD_C_2; cl15862 443218011295 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443218011296 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 443218011297 Lsr2; Region: Lsr2; pfam11774 443218011298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 443218011299 Helix-turn-helix domains; Region: HTH; cl00088 443218011300 Integrase core domain; Region: rve; cl01316 443218011301 Lsr2; Region: Lsr2; pfam11774 443218011302 Helix-turn-helix domains; Region: HTH; cl00088 443218011303 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218011304 CoenzymeA binding site [chemical binding]; other site 443218011305 subunit interaction site [polypeptide binding]; other site 443218011306 PHB binding site; other site 443218011307 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218011308 Helix-turn-helix domain; Region: HTH_18; pfam12833 443218011309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 443218011310 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218011311 catalytic loop [active] 443218011312 iron binding site [ion binding]; other site 443218011313 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218011314 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443218011315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218011316 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 443218011317 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443218011318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443218011319 Transposase, Mutator family; Region: Transposase_mut; pfam00872 443218011320 MULE transposase domain; Region: MULE; pfam10551 443218011321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 443218011322 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 443218011323 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443218011324 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443218011325 catalytic residues [active] 443218011326 catalytic nucleophile [active] 443218011327 Presynaptic Site I dimer interface [polypeptide binding]; other site 443218011328 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443218011329 Synaptic Flat tetramer interface [polypeptide binding]; other site 443218011330 Synaptic Site I dimer interface [polypeptide binding]; other site 443218011331 DNA binding site [nucleotide binding] 443218011332 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218011333 DNA-binding interface [nucleotide binding]; DNA binding site 443218011334 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 443218011335 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 443218011336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218011337 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 443218011338 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 443218011339 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 443218011340 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 443218011341 putative active site [active] 443218011342 urea carboxylase; Region: urea_carbox; TIGR02712 443218011343 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 443218011344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011345 Predicted ATPase [General function prediction only]; Region: COG3899 443218011346 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443218011347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011348 DNA binding residues [nucleotide binding] 443218011349 dimerization interface [polypeptide binding]; other site 443218011350 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443218011351 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443218011352 active site 443218011353 NAD binding site [chemical binding]; other site 443218011354 metal binding site [ion binding]; metal-binding site 443218011355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443218011356 Walker A motif; other site 443218011357 ATP binding site [chemical binding]; other site 443218011358 Walker B motif; other site 443218011359 arginine finger; other site 443218011360 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 443218011361 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 443218011362 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 443218011363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443218011364 S-adenosylmethionine binding site [chemical binding]; other site 443218011365 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 443218011366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011367 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443218011368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011369 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 443218011370 FAD binding site [chemical binding]; other site 443218011371 homotetramer interface [polypeptide binding]; other site 443218011372 substrate binding pocket [chemical binding]; other site 443218011373 catalytic base [active] 443218011374 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218011375 Helix-turn-helix domains; Region: HTH; cl00088 443218011376 Sodium:solute symporter family; Region: SSF; cl00456 443218011377 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 443218011378 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443218011379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011380 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011381 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011382 active site 443218011383 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 443218011384 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 443218011385 FMN binding site [chemical binding]; other site 443218011386 substrate binding site [chemical binding]; other site 443218011387 putative catalytic residue [active] 443218011388 enoyl-CoA hydratase; Provisional; Region: PRK08260 443218011389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218011390 substrate binding site [chemical binding]; other site 443218011391 oxyanion hole (OAH) forming residues; other site 443218011392 trimer interface [polypeptide binding]; other site 443218011393 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218011394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011395 Helix-turn-helix domains; Region: HTH; cl00088 443218011396 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443218011397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011399 active site 443218011400 phosphorylation site [posttranslational modification] 443218011401 intermolecular recognition site; other site 443218011402 dimerization interface [polypeptide binding]; other site 443218011403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011404 DNA binding residues [nucleotide binding] 443218011405 dimerization interface [polypeptide binding]; other site 443218011406 Histidine kinase; Region: HisKA_3; pfam07730 443218011407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218011408 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 443218011409 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443218011410 active site 443218011411 NAD binding site [chemical binding]; other site 443218011412 metal binding site [ion binding]; metal-binding site 443218011413 mycofactocin precursor; Region: mycofactocin; TIGR03969 443218011414 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 443218011415 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 443218011416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218011417 FeS/SAM binding site; other site 443218011418 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 443218011419 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443218011420 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218011421 phosphate binding site [ion binding]; other site 443218011422 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 443218011423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218011424 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443218011425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218011426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 443218011427 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443218011428 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443218011429 anti sigma factor interaction site; other site 443218011430 regulatory phosphorylation site [posttranslational modification]; other site 443218011431 GAF domain; Region: GAF_2; pfam13185 443218011432 GAF domain; Region: GAF; cl15785 443218011433 ANTAR domain; Region: ANTAR; cl04297 443218011434 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 443218011435 active site 443218011436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011437 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443218011438 Walker A/P-loop; other site 443218011439 ATP binding site [chemical binding]; other site 443218011440 Q-loop/lid; other site 443218011441 ABC transporter signature motif; other site 443218011442 Walker B; other site 443218011443 D-loop; other site 443218011444 H-loop/switch region; other site 443218011445 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218011446 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 443218011447 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 443218011448 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011449 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218011450 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443218011451 putative active site [active] 443218011452 putative catalytic site [active] 443218011453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011455 active site 443218011456 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 443218011457 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443218011458 ATP-grasp domain; Region: ATP-grasp_4; cl03087 443218011459 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 443218011460 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443218011461 carboxyltransferase (CT) interaction site; other site 443218011462 biotinylation site [posttranslational modification]; other site 443218011463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218011464 UMP phosphatase; Provisional; Region: PRK10444 443218011465 active site 443218011466 motif I; other site 443218011467 motif II; other site 443218011468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443218011469 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 443218011470 amphipathic channel; other site 443218011471 Asn-Pro-Ala signature motifs; other site 443218011472 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443218011473 glycerol kinase; Provisional; Region: glpK; PRK00047 443218011474 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 443218011475 N- and C-terminal domain interface [polypeptide binding]; other site 443218011476 putative active site [active] 443218011477 putative MgATP binding site [chemical binding]; other site 443218011478 catalytic site [active] 443218011479 metal binding site [ion binding]; metal-binding site 443218011480 putative homotetramer interface [polypeptide binding]; other site 443218011481 putative glycerol binding site [chemical binding]; other site 443218011482 homodimer interface [polypeptide binding]; other site 443218011483 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218011484 Helix-turn-helix domains; Region: HTH; cl00088 443218011485 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218011486 glycerol kinase; Region: glycerol_kin; TIGR01311 443218011487 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 443218011488 N- and C-terminal domain interface [polypeptide binding]; other site 443218011489 active site 443218011490 MgATP binding site [chemical binding]; other site 443218011491 catalytic site [active] 443218011492 metal binding site [ion binding]; metal-binding site 443218011493 carbohydrate binding site [chemical binding]; other site 443218011494 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 443218011495 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 443218011496 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443218011497 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443218011498 Helix-turn-helix domains; Region: HTH; cl00088 443218011499 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 443218011500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443218011501 active site 443218011502 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443218011503 classical (c) SDRs; Region: SDR_c; cd05233 443218011504 NAD(P) binding site [chemical binding]; other site 443218011505 active site 443218011506 Creatinine amidohydrolase; Region: Creatininase; cl00618 443218011507 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 443218011508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 443218011509 phosphate binding site [ion binding]; other site 443218011510 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 443218011511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443218011512 FeS/SAM binding site; other site 443218011513 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 443218011514 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 443218011515 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443218011516 Helix-turn-helix domains; Region: HTH; cl00088 443218011517 AMP-binding domain protein; Validated; Region: PRK08315 443218011518 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011519 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443218011520 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 443218011521 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443218011522 Helix-turn-helix domains; Region: HTH; cl00088 443218011523 Bacterial transcriptional regulator; Region: IclR; pfam01614 443218011524 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 443218011525 amphipathic channel; other site 443218011526 Asn-Pro-Ala signature motifs; other site 443218011527 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 443218011528 Dak1 domain; Region: Dak1; pfam02733 443218011529 DAK2 domain; Region: Dak2; cl03685 443218011530 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 443218011531 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 443218011532 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443218011533 dimerization domain swap beta strand [polypeptide binding]; other site 443218011534 regulatory protein interface [polypeptide binding]; other site 443218011535 active site 443218011536 regulatory phosphorylation site [posttranslational modification]; other site 443218011537 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443218011538 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443218011539 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 443218011540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 443218011541 short chain dehydrogenase; Provisional; Region: PRK05866 443218011542 classical (c) SDRs; Region: SDR_c; cd05233 443218011543 NAD(P) binding site [chemical binding]; other site 443218011544 active site 443218011545 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218011546 cyclase homology domain; Region: CHD; cd07302 443218011547 nucleotidyl binding site; other site 443218011548 metal binding site [ion binding]; metal-binding site 443218011549 dimer interface [polypeptide binding]; other site 443218011550 Transmembrane secretion effector; Region: MFS_3; pfam05977 443218011551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 443218011552 Helix-turn-helix domains; Region: HTH; cl00088 443218011553 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 443218011554 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443218011555 Cation efflux family; Region: Cation_efflux; cl00316 443218011556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218011557 dimerization interface [polypeptide binding]; other site 443218011558 putative DNA binding site [nucleotide binding]; other site 443218011559 putative Zn2+ binding site [ion binding]; other site 443218011560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 443218011561 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 443218011562 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 443218011563 NAD binding site [chemical binding]; other site 443218011564 catalytic Zn binding site [ion binding]; other site 443218011565 substrate binding site [chemical binding]; other site 443218011566 structural Zn binding site [ion binding]; other site 443218011567 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443218011568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011569 NAD(P) binding site [chemical binding]; other site 443218011570 active site 443218011571 Helix-turn-helix domains; Region: HTH; cl00088 443218011572 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443218011573 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 443218011574 Walker A/P-loop; other site 443218011575 ATP binding site [chemical binding]; other site 443218011576 Q-loop/lid; other site 443218011577 ABC transporter signature motif; other site 443218011578 Walker B; other site 443218011579 D-loop; other site 443218011580 H-loop/switch region; other site 443218011581 TOBE domain; Region: TOBE_2; cl01440 443218011582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218011583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218011584 dimer interface [polypeptide binding]; other site 443218011585 conserved gate region; other site 443218011586 putative PBP binding loops; other site 443218011587 ABC-ATPase subunit interface; other site 443218011588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218011589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218011590 dimer interface [polypeptide binding]; other site 443218011591 conserved gate region; other site 443218011592 putative PBP binding loops; other site 443218011593 ABC-ATPase subunit interface; other site 443218011594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218011595 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443218011596 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 443218011597 Helix-turn-helix domains; Region: HTH; cl00088 443218011598 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 443218011599 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443218011600 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 443218011601 inhibitor binding site; inhibition site 443218011602 catalytic Zn binding site [ion binding]; other site 443218011603 structural Zn binding site [ion binding]; other site 443218011604 NADP binding site [chemical binding]; other site 443218011605 tetramer interface [polypeptide binding]; other site 443218011606 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 443218011607 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 443218011608 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 443218011609 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 443218011610 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 443218011611 N- and C-terminal domain interface [polypeptide binding]; other site 443218011612 active site 443218011613 MgATP binding site [chemical binding]; other site 443218011614 catalytic site [active] 443218011615 metal binding site [ion binding]; metal-binding site 443218011616 carbohydrate binding site [chemical binding]; other site 443218011617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443218011618 non-specific DNA binding site [nucleotide binding]; other site 443218011619 salt bridge; other site 443218011620 sequence-specific DNA binding site [nucleotide binding]; other site 443218011621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011622 Helix-turn-helix domains; Region: HTH; cl00088 443218011623 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 443218011624 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011626 active site 443218011627 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 443218011628 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 443218011629 DNA binding residues [nucleotide binding] 443218011630 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443218011631 dimer interface [polypeptide binding]; other site 443218011632 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 443218011633 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011635 active site 443218011636 phosphorylation site [posttranslational modification] 443218011637 intermolecular recognition site; other site 443218011638 dimerization interface [polypeptide binding]; other site 443218011639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011640 DNA binding residues [nucleotide binding] 443218011641 dimerization interface [polypeptide binding]; other site 443218011642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218011643 Histidine kinase; Region: HisKA_3; pfam07730 443218011644 DnaJ_C chaperone protein; Provisional; Region: PTZ00037 443218011645 CsbD-like; Region: CsbD; cl15799 443218011646 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 443218011647 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 443218011648 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 443218011649 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218011650 FMN-binding pocket [chemical binding]; other site 443218011651 flavin binding motif; other site 443218011652 phosphate binding motif [ion binding]; other site 443218011653 beta-alpha-beta structure motif; other site 443218011654 NAD binding pocket [chemical binding]; other site 443218011655 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218011656 catalytic loop [active] 443218011657 iron binding site [ion binding]; other site 443218011658 hypothetical protein; Provisional; Region: PRK07945 443218011659 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 443218011660 Response regulator receiver domain; Region: Response_reg; pfam00072 443218011661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011662 active site 443218011663 phosphorylation site [posttranslational modification] 443218011664 intermolecular recognition site; other site 443218011665 dimerization interface [polypeptide binding]; other site 443218011666 FOG: CBS domain [General function prediction only]; Region: COG0517 443218011667 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 443218011668 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 443218011669 NAD(P) binding site [chemical binding]; other site 443218011670 GXWXG protein; Region: GXWXG; pfam14231 443218011671 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 443218011672 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 443218011673 peptide synthase; Provisional; Region: PRK12316 443218011674 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011675 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218011676 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218011677 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011678 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011679 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011680 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011681 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011682 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218011683 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 443218011684 peptide synthase; Provisional; Region: PRK12467 443218011685 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011686 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218011687 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011688 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011689 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218011690 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 443218011691 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 443218011692 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011693 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443218011694 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 443218011695 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 443218011696 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 443218011697 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 443218011698 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 443218011699 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 443218011700 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 443218011701 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 443218011702 putative dimer interface [polypeptide binding]; other site 443218011703 [2Fe-2S] cluster binding site [ion binding]; other site 443218011704 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 443218011705 SLBB domain; Region: SLBB; pfam10531 443218011706 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 443218011707 NADH dehydrogenase subunit G; Validated; Region: PRK07860 443218011708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218011709 catalytic loop [active] 443218011710 iron binding site [ion binding]; other site 443218011711 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 443218011712 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443218011713 molybdopterin cofactor binding site; other site 443218011714 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 443218011715 NADH dehydrogenase; Region: NADHdh; cl00469 443218011716 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 443218011717 4Fe-4S binding domain; Region: Fer4; cl02805 443218011718 4Fe-4S binding domain; Region: Fer4; cl02805 443218011719 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 443218011720 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 443218011721 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 443218011722 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 443218011723 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 443218011724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218011725 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 443218011726 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218011727 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 443218011728 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 443218011729 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 443218011730 cyclase homology domain; Region: CHD; cd07302 443218011731 nucleotidyl binding site; other site 443218011732 metal binding site [ion binding]; metal-binding site 443218011733 dimer interface [polypeptide binding]; other site 443218011734 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 443218011735 cyclase homology domain; Region: CHD; cd07302 443218011736 nucleotidyl binding site; other site 443218011737 metal binding site [ion binding]; metal-binding site 443218011738 dimer interface [polypeptide binding]; other site 443218011739 Clp amino terminal domain; Region: Clp_N; pfam02861 443218011740 Clp amino terminal domain; Region: Clp_N; pfam02861 443218011741 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 443218011742 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443218011743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011744 Helix-turn-helix domains; Region: HTH; cl00088 443218011745 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 443218011746 cyclase homology domain; Region: CHD; cd07302 443218011747 nucleotidyl binding site; other site 443218011748 metal binding site [ion binding]; metal-binding site 443218011749 dimer interface [polypeptide binding]; other site 443218011750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443218011751 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443218011752 active site 443218011753 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 443218011754 putative active site [active] 443218011755 putative catalytic site [active] 443218011756 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443218011757 active site 2 [active] 443218011758 active site 1 [active] 443218011759 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443218011760 short chain dehydrogenase; Provisional; Region: PRK08278 443218011761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011762 NAD(P) binding site [chemical binding]; other site 443218011763 active site 443218011764 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443218011765 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443218011766 substrate binding site [chemical binding]; other site 443218011767 trimer interface [polypeptide binding]; other site 443218011768 oxyanion hole (OAH) forming residues; other site 443218011769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 443218011770 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 443218011771 Helix-turn-helix domains; Region: HTH; cl00088 443218011772 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 443218011773 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011774 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 443218011775 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443218011776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011777 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 443218011778 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218011779 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 443218011780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011781 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 443218011782 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443218011783 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011784 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011785 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 443218011786 putative active site [active] 443218011787 putative FMN binding site [chemical binding]; other site 443218011788 putative substrate binding site [chemical binding]; other site 443218011789 putative catalytic residue [active] 443218011790 Domain of unknown function (DUF385); Region: DUF385; cl04387 443218011791 Helix-turn-helix domains; Region: HTH; cl00088 443218011792 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 443218011793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443218011794 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443218011795 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443218011796 putative di-iron ligands [ion binding]; other site 443218011797 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 443218011798 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 443218011799 FAD binding pocket [chemical binding]; other site 443218011800 conserved FAD binding motif [chemical binding]; other site 443218011801 phosphate binding motif [ion binding]; other site 443218011802 beta-alpha-beta structure motif; other site 443218011803 NAD binding pocket [chemical binding]; other site 443218011804 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443218011805 catalytic loop [active] 443218011806 iron binding site [ion binding]; other site 443218011807 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 443218011808 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 443218011809 putative active site [active] 443218011810 metal binding site [ion binding]; metal-binding site 443218011811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 443218011812 classical (c) SDRs; Region: SDR_c; cd05233 443218011813 NAD(P) binding site [chemical binding]; other site 443218011814 active site 443218011815 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 443218011816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011817 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 443218011818 short chain dehydrogenase; Provisional; Region: PRK07825 443218011819 classical (c) SDRs; Region: SDR_c; cd05233 443218011820 NAD(P) binding site [chemical binding]; other site 443218011821 active site 443218011822 GAF domain; Region: GAF_2; pfam13185 443218011823 GAF domain; Region: GAF; cl15785 443218011824 ANTAR domain; Region: ANTAR; cl04297 443218011825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 443218011826 NMT1-like family; Region: NMT1_2; cl15260 443218011827 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 443218011828 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 443218011829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 443218011830 NMT1-like family; Region: NMT1_2; cl15260 443218011831 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 443218011832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 443218011833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218011834 ATP binding site [chemical binding]; other site 443218011835 Mg2+ binding site [ion binding]; other site 443218011836 G-X-G motif; other site 443218011837 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443218011838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443218011839 active site 443218011840 phosphorylation site [posttranslational modification] 443218011841 intermolecular recognition site; other site 443218011842 dimerization interface [polypeptide binding]; other site 443218011843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011844 NAD(P) binding site [chemical binding]; other site 443218011845 active site 443218011846 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 443218011847 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218011848 short chain dehydrogenase; Provisional; Region: PRK07201 443218011849 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 443218011850 putative NAD(P) binding site [chemical binding]; other site 443218011851 active site 443218011852 putative substrate binding site [chemical binding]; other site 443218011853 classical (c) SDRs; Region: SDR_c; cd05233 443218011854 NAD(P) binding site [chemical binding]; other site 443218011855 active site 443218011856 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 443218011857 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 443218011859 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443218011860 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 443218011861 Helix-turn-helix domains; Region: HTH; cl00088 443218011862 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 443218011863 dimerization interface [polypeptide binding]; other site 443218011864 substrate binding pocket [chemical binding]; other site 443218011865 short chain dehydrogenase; Provisional; Region: PRK12744 443218011866 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 443218011867 NADP binding site [chemical binding]; other site 443218011868 homodimer interface [polypeptide binding]; other site 443218011869 active site 443218011870 substrate binding site [chemical binding]; other site 443218011871 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 443218011872 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 443218011873 Helix-turn-helix domains; Region: HTH; cl00088 443218011874 acyl-CoA synthetase; Validated; Region: PRK07788 443218011875 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011876 AMP-binding enzyme; Region: AMP-binding; cl15778 443218011877 Secretory lipase; Region: LIP; pfam03583 443218011878 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 443218011879 DinB superfamily; Region: DinB_2; pfam12867 443218011880 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 443218011881 putative hydrophobic ligand binding site [chemical binding]; other site 443218011882 aconitate hydratase; Validated; Region: PRK07229 443218011883 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443218011884 substrate binding site [chemical binding]; other site 443218011885 ligand binding site [chemical binding]; other site 443218011886 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 443218011887 substrate binding site [chemical binding]; other site 443218011888 OpgC protein; Region: OpgC_C; cl00792 443218011889 Glutaminase; Region: Glutaminase; cl00907 443218011890 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443218011891 Helix-turn-helix domains; Region: HTH; cl00088 443218011892 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 443218011893 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 443218011894 ABC-2 type transporter; Region: ABC2_membrane; cl11417 443218011895 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 443218011896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218011897 Walker A/P-loop; other site 443218011898 ATP binding site [chemical binding]; other site 443218011899 Q-loop/lid; other site 443218011900 ABC transporter signature motif; other site 443218011901 Walker B; other site 443218011902 D-loop; other site 443218011903 H-loop/switch region; other site 443218011904 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443218011905 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 443218011906 homotrimer interaction site [polypeptide binding]; other site 443218011907 putative active site [active] 443218011908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443218011909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443218011910 Coenzyme A binding pocket [chemical binding]; other site 443218011911 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 443218011912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218011913 Protein of unknown function DUF262; Region: DUF262; cl14890 443218011914 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 443218011915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443218011916 dimerization interface [polypeptide binding]; other site 443218011917 putative DNA binding site [nucleotide binding]; other site 443218011918 putative Zn2+ binding site [ion binding]; other site 443218011919 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443218011920 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 443218011921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218011922 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 443218011923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218011924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 443218011925 YCII-related domain; Region: YCII; cl00999 443218011926 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443218011927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218011928 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 443218011929 NAD(P) binding site [chemical binding]; other site 443218011930 LDH/MDH dimer interface [polypeptide binding]; other site 443218011931 substrate binding site [chemical binding]; other site 443218011932 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443218011933 CoenzymeA binding site [chemical binding]; other site 443218011934 subunit interaction site [polypeptide binding]; other site 443218011935 PHB binding site; other site 443218011936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218011937 Helix-turn-helix domains; Region: HTH; cl00088 443218011938 Cupin domain; Region: Cupin_2; cl09118 443218011939 replicative DNA helicase; Provisional; Region: PRK05636 443218011940 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443218011941 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443218011942 Walker A motif; other site 443218011943 ATP binding site [chemical binding]; other site 443218011944 Walker B motif; other site 443218011945 DNA binding loops [nucleotide binding] 443218011946 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443218011947 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443218011948 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443218011949 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 443218011950 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443218011951 dimer interface [polypeptide binding]; other site 443218011952 ssDNA binding site [nucleotide binding]; other site 443218011953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443218011954 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 443218011955 endonuclease IV; Provisional; Region: PRK01060 443218011956 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 443218011957 AP (apurinic/apyrimidinic) site pocket; other site 443218011958 DNA interaction; other site 443218011959 Metal-binding active site; metal-binding site 443218011960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011962 DNA binding residues [nucleotide binding] 443218011963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443218011964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443218011965 ATP binding site [chemical binding]; other site 443218011966 Mg2+ binding site [ion binding]; other site 443218011967 G-X-G motif; other site 443218011968 Helix-turn-helix domains; Region: HTH; cl00088 443218011969 DNA binding residues [nucleotide binding] 443218011970 dimerization interface [polypeptide binding]; other site 443218011971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443218011972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443218011973 DNA binding residues [nucleotide binding] 443218011974 Proline dehydrogenase; Region: Pro_dh; cl03282 443218011975 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 443218011976 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 443218011977 Transglycosylase; Region: Transgly; cl07896 443218011978 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 443218011979 Helix-turn-helix domains; Region: HTH; cl00088 443218011980 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 443218011981 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 443218011982 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 443218011983 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443218011984 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 443218011985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443218011986 nucleophilic elbow; other site 443218011987 catalytic triad; other site 443218011988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443218011989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218011990 dimer interface [polypeptide binding]; other site 443218011991 conserved gate region; other site 443218011992 putative PBP binding loops; other site 443218011993 ABC-ATPase subunit interface; other site 443218011994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443218011995 dimer interface [polypeptide binding]; other site 443218011996 conserved gate region; other site 443218011997 putative PBP binding loops; other site 443218011998 ABC-ATPase subunit interface; other site 443218011999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443218012000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443218012001 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 443218012002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443218012003 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 443218012004 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443218012005 classical (c) SDRs; Region: SDR_c; cd05233 443218012006 NAD(P) binding site [chemical binding]; other site 443218012007 active site 443218012008 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443218012009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012010 active site 443218012011 HIGH motif; other site 443218012012 nucleotide binding site [chemical binding]; other site 443218012013 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443218012014 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012015 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443218012016 active site 443218012017 KMSKS motif; other site 443218012018 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443218012019 tRNA binding surface [nucleotide binding]; other site 443218012020 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443218012021 SdpI/YhfL protein family; Region: SdpI; pfam13630 443218012022 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443218012023 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 443218012024 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 443218012025 Membrane transport protein; Region: Mem_trans; cl09117 443218012026 L-lysine aminotransferase; Provisional; Region: PRK08297 443218012027 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443218012028 inhibitor-cofactor binding pocket; inhibition site 443218012029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443218012030 catalytic residue [active] 443218012031 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 443218012032 H+ Antiporter protein; Region: 2A0121; TIGR00900 443218012033 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443218012034 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443218012035 active site 443218012036 NTP binding site [chemical binding]; other site 443218012037 metal binding triad [ion binding]; metal-binding site 443218012038 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443218012039 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443218012040 Zn2+ binding site [ion binding]; other site 443218012041 Mg2+ binding site [ion binding]; other site 443218012042 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443218012043 active site 443218012044 metal binding site [ion binding]; metal-binding site 443218012045 Ap6A binding site [chemical binding]; other site 443218012046 integral membrane protein MviN; Region: mviN; TIGR01695 443218012047 MatE; Region: MatE; cl10513 443218012048 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 443218012049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443218012050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443218012051 DNA binding residues [nucleotide binding] 443218012052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443218012053 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443218012054 DNA-binding interface [nucleotide binding]; DNA binding site 443218012055 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443218012056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443218012057 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443218012058 catalytic residues [active] 443218012059 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 443218012060 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 443218012061 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 443218012062 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 443218012063 active site 443218012064 metal binding site [ion binding]; metal-binding site 443218012065 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 443218012066 ParB-like nuclease domain; Region: ParBc; cl02129 443218012067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443218012068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218012069 P-loop; other site 443218012070 Magnesium ion binding site [ion binding]; other site 443218012071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 443218012072 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443218012073 Magnesium ion binding site [ion binding]; other site 443218012074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 443218012075 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443218012076 G-X-X-G motif; other site 443218012077 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443218012078 RxxxH motif; other site 443218012079 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 443218012080 Haemolytic domain; Region: Haemolytic; cl00506 443218012081 Ribosomal protein L34; Region: Ribosomal_L34; cl00370