-- dump date 20120504_132922 -- class Genbank::misc_feature -- table misc_feature_note -- id note 525919000001 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 525919000002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919000003 FeS/SAM binding site; other site 525919000004 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525919000005 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525919000006 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000007 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 525919000008 Walker A/P-loop; other site 525919000009 ATP binding site [chemical binding]; other site 525919000010 ABC transporter; Region: ABC_tran; pfam00005 525919000011 Q-loop/lid; other site 525919000012 ABC transporter signature motif; other site 525919000013 Walker B; other site 525919000014 D-loop; other site 525919000015 H-loop/switch region; other site 525919000016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525919000017 active site 525919000018 ATP binding site [chemical binding]; other site 525919000019 substrate binding site [chemical binding]; other site 525919000020 activation loop (A-loop); other site 525919000021 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 525919000022 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 525919000023 active site 525919000024 zinc binding site [ion binding]; other site 525919000025 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919000028 Walker A/P-loop; other site 525919000029 ATP binding site [chemical binding]; other site 525919000030 Q-loop/lid; other site 525919000031 ABC transporter signature motif; other site 525919000032 Walker B; other site 525919000033 D-loop; other site 525919000034 H-loop/switch region; other site 525919000035 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 525919000036 primary metal binding site; other site 525919000037 catalytic residues [active] 525919000038 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 525919000039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919000040 FeS/SAM binding site; other site 525919000041 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525919000042 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919000043 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919000044 Walker A/P-loop; other site 525919000045 ATP binding site [chemical binding]; other site 525919000046 Q-loop/lid; other site 525919000047 ABC transporter signature motif; other site 525919000048 Walker B; other site 525919000049 D-loop; other site 525919000050 H-loop/switch region; other site 525919000051 FtsX-like permease family; Region: FtsX; cl15850 525919000052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919000053 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 525919000054 Walker A/P-loop; other site 525919000055 ATP binding site [chemical binding]; other site 525919000056 Q-loop/lid; other site 525919000057 ABC transporter signature motif; other site 525919000058 Walker B; other site 525919000059 D-loop; other site 525919000060 H-loop/switch region; other site 525919000061 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 525919000062 Myosin heavy chain [Cytoskeleton]; Region: COG5022 525919000063 Helix-turn-helix domains; Region: HTH; cl00088 525919000064 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 525919000065 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 525919000066 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 525919000067 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 525919000068 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 525919000069 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 525919000070 AMP-binding enzyme; Region: AMP-binding; cl15778 525919000071 AMP-binding enzyme; Region: AMP-binding; cl15778 525919000072 Phosphopantetheine attachment site; Region: PP-binding; cl09936 525919000073 Condensation domain; Region: Condensation; pfam00668 525919000074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 525919000075 Nonribosomal peptide synthase; Region: NRPS; pfam08415 525919000076 AMP-binding enzyme; Region: AMP-binding; cl15778 525919000077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000078 peptide synthase; Validated; Region: PRK05691 525919000079 Phosphopantetheine attachment site; Region: PP-binding; cl09936 525919000080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000081 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 525919000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919000083 S-adenosylmethionine binding site [chemical binding]; other site 525919000084 Condensation domain; Region: Condensation; pfam00668 525919000085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 525919000086 Nonribosomal peptide synthase; Region: NRPS; pfam08415 525919000087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000088 dimer interface [polypeptide binding]; other site 525919000089 conserved gate region; other site 525919000090 putative PBP binding loops; other site 525919000091 ABC-ATPase subunit interface; other site 525919000092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525919000093 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919000094 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 525919000095 Walker A/P-loop; other site 525919000096 ATP binding site [chemical binding]; other site 525919000097 Q-loop/lid; other site 525919000098 ABC transporter signature motif; other site 525919000099 Walker B; other site 525919000100 D-loop; other site 525919000101 H-loop/switch region; other site 525919000102 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919000103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919000104 Walker A/P-loop; other site 525919000105 ATP binding site [chemical binding]; other site 525919000106 Q-loop/lid; other site 525919000107 ABC transporter signature motif; other site 525919000108 Walker B; other site 525919000109 D-loop; other site 525919000110 H-loop/switch region; other site 525919000111 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 525919000112 substrate binding site [chemical binding]; other site 525919000113 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 525919000114 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919000115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525919000116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919000117 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000119 Walker A/P-loop; other site 525919000120 ATP binding site [chemical binding]; other site 525919000121 Q-loop/lid; other site 525919000122 ABC transporter signature motif; other site 525919000123 Walker B; other site 525919000124 D-loop; other site 525919000125 H-loop/switch region; other site 525919000126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919000127 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000128 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 525919000129 Walker A/P-loop; other site 525919000130 ATP binding site [chemical binding]; other site 525919000131 Q-loop/lid; other site 525919000132 ABC transporter signature motif; other site 525919000133 Walker B; other site 525919000134 D-loop; other site 525919000135 H-loop/switch region; other site 525919000136 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 525919000137 catalytic residues [active] 525919000138 catalytic nucleophile [active] 525919000139 Recombinase; Region: Recombinase; pfam07508 525919000140 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 525919000141 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 525919000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919000143 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 525919000144 MobA/MobL family; Region: MobA_MobL; pfam03389 525919000145 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 525919000146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525919000147 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 525919000148 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 525919000149 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 525919000150 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 525919000151 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 525919000152 catalytic residues [active] 525919000153 catalytic nucleophile [active] 525919000154 Recombinase; Region: Recombinase; pfam07508 525919000155 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 525919000156 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 525919000157 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525919000158 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525919000159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919000160 non-specific DNA binding site [nucleotide binding]; other site 525919000161 salt bridge; other site 525919000162 sequence-specific DNA binding site [nucleotide binding]; other site 525919000163 Helix-turn-helix domains; Region: HTH; cl00088 525919000164 hypothetical protein; Validated; Region: PRK08116 525919000165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919000166 Walker A motif; other site 525919000167 ATP binding site [chemical binding]; other site 525919000168 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 525919000169 BRO family, N-terminal domain; Region: Bro-N; cl10591 525919000170 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 525919000171 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 525919000172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000173 Walker A motif; other site 525919000174 ATP binding site [chemical binding]; other site 525919000175 Walker B motif; other site 525919000176 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 525919000177 generic binding surface II; other site 525919000178 generic binding surface I; other site 525919000179 Maff2 family; Region: Maff2; pfam12750 525919000180 PrgI family protein; Region: PrgI; pfam12666 525919000181 AAA-like domain; Region: AAA_10; pfam12846 525919000182 Domain of unknown function DUF87; Region: DUF87; pfam01935 525919000183 NlpC/P60 family; Region: NLPC_P60; cl11438 525919000184 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 525919000185 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 525919000186 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 525919000187 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 525919000188 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525919000189 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 525919000190 DNA topoisomerase III; Provisional; Region: PRK07726 525919000191 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 525919000192 active site 525919000193 putative interdomain interaction site [polypeptide binding]; other site 525919000194 putative metal-binding site [ion binding]; other site 525919000195 putative nucleotide binding site [chemical binding]; other site 525919000196 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525919000197 domain I; other site 525919000198 DNA binding groove [nucleotide binding] 525919000199 phosphate binding site [ion binding]; other site 525919000200 domain II; other site 525919000201 domain III; other site 525919000202 nucleotide binding site [chemical binding]; other site 525919000203 catalytic site [active] 525919000204 domain IV; other site 525919000205 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 525919000206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 525919000207 cofactor binding site; other site 525919000208 DNA binding site [nucleotide binding] 525919000209 substrate interaction site [chemical binding]; other site 525919000210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000213 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000214 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 525919000215 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 525919000216 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 525919000217 putative active site [active] 525919000218 putative NTP binding site [chemical binding]; other site 525919000219 putative nucleic acid binding site [nucleotide binding]; other site 525919000220 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 525919000221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 525919000222 RelB antitoxin; Region: RelB; cl01171 525919000223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919000225 active site 525919000226 phosphorylation site [posttranslational modification] 525919000227 intermolecular recognition site; other site 525919000228 dimerization interface [polypeptide binding]; other site 525919000229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919000230 DNA binding site [nucleotide binding] 525919000231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919000232 dimer interface [polypeptide binding]; other site 525919000233 phosphorylation site [posttranslational modification] 525919000234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919000235 ATP binding site [chemical binding]; other site 525919000236 Mg2+ binding site [ion binding]; other site 525919000237 G-X-G motif; other site 525919000238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525919000239 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 525919000240 Walker A/P-loop; other site 525919000241 ATP binding site [chemical binding]; other site 525919000242 Q-loop/lid; other site 525919000243 ABC transporter signature motif; other site 525919000244 Walker B; other site 525919000245 D-loop; other site 525919000246 H-loop/switch region; other site 525919000247 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 525919000248 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 525919000249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919000250 FeS/SAM binding site; other site 525919000251 putative bacteriocin precursor, CLOSPO_01332 family; Region: oc_CLOSPO_01332; TIGR04067 525919000252 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525919000254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000255 Walker A/P-loop; other site 525919000256 ATP binding site [chemical binding]; other site 525919000257 Q-loop/lid; other site 525919000258 ABC transporter signature motif; other site 525919000259 Walker B; other site 525919000260 D-loop; other site 525919000261 H-loop/switch region; other site 525919000262 VanZ like family; Region: VanZ; cl01971 525919000263 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525919000264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919000265 FeS/SAM binding site; other site 525919000266 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525919000267 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919000268 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 525919000269 Walker A/P-loop; other site 525919000270 ATP binding site [chemical binding]; other site 525919000271 Q-loop/lid; other site 525919000272 ABC transporter signature motif; other site 525919000273 Walker B; other site 525919000274 D-loop; other site 525919000275 H-loop/switch region; other site 525919000276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525919000277 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525919000278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919000279 active site 525919000280 phosphorylation site [posttranslational modification] 525919000281 intermolecular recognition site; other site 525919000282 dimerization interface [polypeptide binding]; other site 525919000283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525919000284 DNA binding residues [nucleotide binding] 525919000285 dimerization interface [polypeptide binding]; other site 525919000286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525919000287 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525919000288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919000289 active site 525919000290 phosphorylation site [posttranslational modification] 525919000291 intermolecular recognition site; other site 525919000292 dimerization interface [polypeptide binding]; other site 525919000293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525919000294 DNA binding residues [nucleotide binding] 525919000295 dimerization interface [polypeptide binding]; other site 525919000296 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 525919000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919000298 Walker A motif; other site 525919000299 ATP binding site [chemical binding]; other site 525919000300 Walker B motif; other site 525919000301 arginine finger; other site 525919000302 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525919000303 DnaA box-binding interface [nucleotide binding]; other site 525919000304 DNA polymerase III subunit beta; Validated; Region: PRK05643 525919000305 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 525919000306 putative DNA binding surface [nucleotide binding]; other site 525919000307 dimer interface [polypeptide binding]; other site 525919000308 beta-clamp/clamp loader binding surface; other site 525919000309 beta-clamp/translesion DNA polymerase binding surface; other site 525919000310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525919000311 recombination protein F; Reviewed; Region: recF; PRK00064 525919000312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000313 Walker A/P-loop; other site 525919000314 ATP binding site [chemical binding]; other site 525919000315 Q-loop/lid; other site 525919000316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000317 ABC transporter signature motif; other site 525919000318 Walker B; other site 525919000319 D-loop; other site 525919000320 H-loop/switch region; other site 525919000321 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 525919000322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 525919000323 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525919000324 anchoring element; other site 525919000325 dimer interface [polypeptide binding]; other site 525919000326 ATP binding site [chemical binding]; other site 525919000327 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525919000328 active site 525919000329 putative metal-binding site [ion binding]; other site 525919000330 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525919000331 DNA gyrase subunit A; Validated; Region: PRK05560 525919000332 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 525919000333 CAP-like domain; other site 525919000334 active site 525919000335 primary dimer interface [polypeptide binding]; other site 525919000336 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000337 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525919000342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525919000343 anti sigma factor interaction site; other site 525919000344 regulatory phosphorylation site [posttranslational modification]; other site 525919000345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 525919000346 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 525919000347 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 525919000348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525919000349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525919000350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525919000351 DNA binding residues [nucleotide binding] 525919000352 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 525919000353 Uncharacterized conserved protein [Function unknown]; Region: COG2461 525919000354 Family of unknown function (DUF438); Region: DUF438; pfam04282 525919000355 PAS domain; Region: PAS_10; pfam13596 525919000356 Cupin domain; Region: Cupin_2; cl09118 525919000357 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525919000358 NlpC/P60 family; Region: NLPC_P60; cl11438 525919000359 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525919000360 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525919000361 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 525919000362 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525919000363 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 525919000364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525919000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000366 dimer interface [polypeptide binding]; other site 525919000367 conserved gate region; other site 525919000368 putative PBP binding loops; other site 525919000369 ABC-ATPase subunit interface; other site 525919000370 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 525919000371 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 525919000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000373 dimer interface [polypeptide binding]; other site 525919000374 conserved gate region; other site 525919000375 putative PBP binding loops; other site 525919000376 ABC-ATPase subunit interface; other site 525919000377 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525919000378 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919000379 Walker A/P-loop; other site 525919000380 ATP binding site [chemical binding]; other site 525919000381 Q-loop/lid; other site 525919000382 ABC transporter signature motif; other site 525919000383 Walker B; other site 525919000384 D-loop; other site 525919000385 H-loop/switch region; other site 525919000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525919000387 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525919000388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000389 Walker A/P-loop; other site 525919000390 ATP binding site [chemical binding]; other site 525919000391 Q-loop/lid; other site 525919000392 Walker B; other site 525919000393 D-loop; other site 525919000394 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919000395 Q-loop/lid; other site 525919000396 ABC transporter signature motif; other site 525919000397 Walker B; other site 525919000398 D-loop; other site 525919000399 H-loop/switch region; other site 525919000400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525919000401 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 525919000402 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 525919000403 glutaminase active site [active] 525919000404 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525919000405 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525919000406 dimer interface [polypeptide binding]; other site 525919000407 active site 525919000408 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 525919000409 dimer interface [polypeptide binding]; other site 525919000410 active site 525919000411 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 525919000412 Uncharacterized conserved protein [Function unknown]; Region: COG1915 525919000413 Uncharacterized conserved protein [Function unknown]; Region: COG1915 525919000414 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525919000415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525919000416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525919000417 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 525919000418 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 525919000419 carbamate kinase; Reviewed; Region: PRK12686 525919000420 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 525919000421 putative substrate binding site [chemical binding]; other site 525919000422 nucleotide binding site [chemical binding]; other site 525919000423 nucleotide binding site [chemical binding]; other site 525919000424 homodimer interface [polypeptide binding]; other site 525919000425 Clp amino terminal domain; Region: Clp_N; pfam02861 525919000426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919000427 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525919000428 Walker A motif; other site 525919000429 ATP binding site [chemical binding]; other site 525919000430 Walker B motif; other site 525919000431 arginine finger; other site 525919000432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000433 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 525919000434 ornithine carbamoyltransferase; Validated; Region: PRK02102 525919000435 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525919000436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000437 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 525919000438 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525919000439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525919000440 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919000441 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525919000442 Helix-turn-helix domains; Region: HTH; cl00088 525919000443 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 525919000444 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 525919000445 intersubunit interface [polypeptide binding]; other site 525919000446 active site 525919000447 catalytic residue [active] 525919000448 Sulfatase; Region: Sulfatase; cl10460 525919000449 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 525919000450 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 525919000451 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 525919000452 Nucleoside recognition; Region: Gate; cl00486 525919000453 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 525919000454 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 525919000455 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 525919000456 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 525919000457 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 525919000458 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525919000459 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525919000460 ornithine carbamoyltransferase; Validated; Region: PRK02102 525919000461 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525919000462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000463 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 525919000464 zinc binding site [ion binding]; other site 525919000465 putative ligand binding site [chemical binding]; other site 525919000466 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 525919000467 TM-ABC transporter signature motif; other site 525919000468 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 525919000469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000470 Walker A/P-loop; other site 525919000471 ATP binding site [chemical binding]; other site 525919000472 Q-loop/lid; other site 525919000473 ABC transporter signature motif; other site 525919000474 Walker B; other site 525919000475 D-loop; other site 525919000476 H-loop/switch region; other site 525919000477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525919000478 dimerization interface [polypeptide binding]; other site 525919000479 putative DNA binding site [nucleotide binding]; other site 525919000480 Predicted transcriptional regulator [Transcription]; Region: COG4742 525919000481 putative Zn2+ binding site [ion binding]; other site 525919000482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525919000483 H+ Antiporter protein; Region: 2A0121; TIGR00900 525919000484 putative substrate translocation pore; other site 525919000485 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 525919000486 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 525919000487 catalytic residue [active] 525919000488 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 525919000489 catalytic residues [active] 525919000490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525919000491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525919000492 peroxiredoxin; Region: AhpC; TIGR03137 525919000493 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 525919000494 dimer interface [polypeptide binding]; other site 525919000495 decamer (pentamer of dimers) interface [polypeptide binding]; other site 525919000496 catalytic triad [active] 525919000497 peroxidatic and resolving cysteines [active] 525919000498 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 525919000499 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 525919000500 active site 525919000501 multimer interface [polypeptide binding]; other site 525919000502 EamA-like transporter family; Region: EamA; cl01037 525919000503 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 525919000504 EamA-like transporter family; Region: EamA; cl01037 525919000505 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525919000506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919000507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000508 dimer interface [polypeptide binding]; other site 525919000509 conserved gate region; other site 525919000510 putative PBP binding loops; other site 525919000511 ABC-ATPase subunit interface; other site 525919000512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525919000513 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525919000514 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 525919000515 Walker A/P-loop; other site 525919000516 ATP binding site [chemical binding]; other site 525919000517 Q-loop/lid; other site 525919000518 ABC transporter signature motif; other site 525919000519 Walker B; other site 525919000520 D-loop; other site 525919000521 H-loop/switch region; other site 525919000522 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525919000523 Glycerate kinase family; Region: Gly_kinase; cl00841 525919000524 Rhomboid family; Region: Rhomboid; cl11446 525919000525 oligoendopeptidase F; Region: pepF; TIGR00181 525919000526 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 525919000527 active site 525919000528 Zn binding site [ion binding]; other site 525919000529 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 525919000530 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525919000531 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 525919000532 active site 525919000533 substrate binding site [chemical binding]; other site 525919000534 ATP binding site [chemical binding]; other site 525919000535 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 525919000536 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 525919000537 active site 525919000538 catalytic site [active] 525919000539 metal binding site [ion binding]; metal-binding site 525919000540 dimer interface [polypeptide binding]; other site 525919000541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525919000542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919000543 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525919000544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000545 dimer interface [polypeptide binding]; other site 525919000546 putative PBP binding loops; other site 525919000547 ABC-ATPase subunit interface; other site 525919000548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000549 dimer interface [polypeptide binding]; other site 525919000550 conserved gate region; other site 525919000551 putative PBP binding loops; other site 525919000552 ABC-ATPase subunit interface; other site 525919000553 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525919000554 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 525919000555 Walker A/P-loop; other site 525919000556 ATP binding site [chemical binding]; other site 525919000557 Q-loop/lid; other site 525919000558 ABC transporter signature motif; other site 525919000559 Walker B; other site 525919000560 D-loop; other site 525919000561 H-loop/switch region; other site 525919000562 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 525919000563 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525919000564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919000565 FeS/SAM binding site; other site 525919000566 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 525919000567 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 525919000568 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 525919000569 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 525919000570 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 525919000571 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 525919000572 catalytic site [active] 525919000573 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525919000574 Helix-turn-helix domains; Region: HTH; cl00088 525919000575 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 525919000576 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 525919000577 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525919000578 dimer interface [polypeptide binding]; other site 525919000579 active site 525919000580 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 525919000581 putative active site [active] 525919000582 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525919000583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919000584 DNA-binding site [nucleotide binding]; DNA binding site 525919000585 UTRA domain; Region: UTRA; cl01230 525919000586 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 525919000587 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 525919000588 active site 525919000589 dimer interface [polypeptide binding]; other site 525919000590 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 525919000591 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 525919000592 putative substrate binding site [chemical binding]; other site 525919000593 putative ATP binding site [chemical binding]; other site 525919000594 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 525919000595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 525919000596 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 525919000597 FAD binding site [chemical binding]; other site 525919000598 homotetramer interface [polypeptide binding]; other site 525919000599 substrate binding pocket [chemical binding]; other site 525919000600 catalytic base [active] 525919000601 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 525919000602 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525919000603 iron binding site [ion binding]; other site 525919000604 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 525919000605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919000606 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 525919000607 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 525919000608 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919000609 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525919000610 active site turn [active] 525919000611 phosphorylation site [posttranslational modification] 525919000612 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 525919000613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919000614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919000615 active site 525919000616 phosphorylation site [posttranslational modification] 525919000617 intermolecular recognition site; other site 525919000618 dimerization interface [polypeptide binding]; other site 525919000619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919000620 DNA binding site [nucleotide binding] 525919000621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 525919000622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919000623 dimer interface [polypeptide binding]; other site 525919000624 phosphorylation site [posttranslational modification] 525919000625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919000626 ATP binding site [chemical binding]; other site 525919000627 Mg2+ binding site [ion binding]; other site 525919000628 G-X-G motif; other site 525919000629 4Fe-4S binding domain; Region: Fer4_5; pfam12801 525919000630 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 525919000631 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525919000632 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525919000633 catalytic residues [active] 525919000634 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 525919000635 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 525919000636 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 525919000637 putative active site [active] 525919000638 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 525919000639 Aspartase; Region: Aspartase; cd01357 525919000640 active sites [active] 525919000641 tetramer interface [polypeptide binding]; other site 525919000642 fumarate hydratase; Reviewed; Region: fumC; PRK00485 525919000643 Class II fumarases; Region: Fumarase_classII; cd01362 525919000644 active site 525919000645 tetramer interface [polypeptide binding]; other site 525919000646 IKI3 family; Region: IKI3; pfam04762 525919000647 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919000648 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525919000649 active site 2 [active] 525919000650 active site 1 [active] 525919000651 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919000652 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 525919000653 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 525919000654 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525919000655 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 525919000656 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 525919000657 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 525919000658 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 525919000659 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919000660 MatE; Region: MatE; cl10513 525919000661 MatE; Region: MatE; cl10513 525919000662 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525919000663 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919000664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919000665 motif II; other site 525919000666 Chromate transporter; Region: Chromate_transp; pfam02417 525919000667 Chromate transporter; Region: Chromate_transp; pfam02417 525919000668 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 525919000669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000670 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 525919000671 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 525919000672 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 525919000673 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 525919000674 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525919000675 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525919000676 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525919000677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919000678 motif II; other site 525919000679 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525919000680 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 525919000681 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 525919000682 putative oligomer interface [polypeptide binding]; other site 525919000683 putative active site [active] 525919000684 metal binding site [ion binding]; metal-binding site 525919000685 Scramblase; Region: Scramblase; cl02043 525919000686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525919000687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525919000688 DNA binding site [nucleotide binding] 525919000689 domain linker motif; other site 525919000690 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525919000691 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 525919000692 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 525919000693 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 525919000694 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 525919000695 dimer interaction site [polypeptide binding]; other site 525919000696 substrate-binding tunnel; other site 525919000697 active site 525919000698 catalytic site [active] 525919000699 substrate binding site [chemical binding]; other site 525919000700 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 525919000701 Membrane transport protein; Region: Mem_trans; cl09117 525919000702 pantoate--beta-alanine ligase; Region: panC; TIGR00018 525919000703 Pantoate-beta-alanine ligase; Region: PanC; cd00560 525919000704 active site 525919000705 ATP-binding site [chemical binding]; other site 525919000706 pantoate-binding site; other site 525919000707 HXXH motif; other site 525919000708 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 525919000709 tetramerization interface [polypeptide binding]; other site 525919000710 active site 525919000711 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 525919000712 LemA family; Region: LemA; cl00742 525919000713 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525919000714 Cation transport protein; Region: TrkH; cl10514 525919000715 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525919000716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000717 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 525919000718 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 525919000719 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 525919000720 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 525919000721 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 525919000722 phosphagen binding site; other site 525919000723 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 525919000724 Clp amino terminal domain; Region: Clp_N; pfam02861 525919000725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919000726 Walker A motif; other site 525919000727 ATP binding site [chemical binding]; other site 525919000728 Walker B motif; other site 525919000729 arginine finger; other site 525919000730 UvrB/uvrC motif; Region: UVR; pfam02151 525919000731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919000732 Walker A motif; other site 525919000733 ATP binding site [chemical binding]; other site 525919000734 Walker B motif; other site 525919000735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 525919000736 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 525919000737 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 525919000738 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 525919000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000740 dimer interface [polypeptide binding]; other site 525919000741 conserved gate region; other site 525919000742 putative PBP binding loops; other site 525919000743 ABC-ATPase subunit interface; other site 525919000744 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 525919000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000746 dimer interface [polypeptide binding]; other site 525919000747 conserved gate region; other site 525919000748 putative PBP binding loops; other site 525919000749 ABC-ATPase subunit interface; other site 525919000750 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525919000751 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 525919000752 Walker A/P-loop; other site 525919000753 ATP binding site [chemical binding]; other site 525919000754 Q-loop/lid; other site 525919000755 ABC transporter signature motif; other site 525919000756 Walker B; other site 525919000757 D-loop; other site 525919000758 H-loop/switch region; other site 525919000759 TOBE domain; Region: TOBE_2; cl01440 525919000760 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 525919000761 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 525919000762 DNA binding site [nucleotide binding] 525919000763 active site 525919000764 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 525919000765 DNA repair protein RadA; Provisional; Region: PRK11823 525919000766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000767 Walker A motif; other site 525919000768 ATP binding site [chemical binding]; other site 525919000769 Walker B motif; other site 525919000770 FMN-binding domain; Region: FMN_bind; cl01081 525919000771 FMN-binding domain; Region: FMN_bind; cl01081 525919000772 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 525919000773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000774 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 525919000775 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919000776 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 525919000777 trimer interface [polypeptide binding]; other site 525919000778 active site 525919000779 G bulge; other site 525919000780 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 525919000781 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 525919000782 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525919000783 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 525919000784 Walker A/P-loop; other site 525919000785 ATP binding site [chemical binding]; other site 525919000786 Q-loop/lid; other site 525919000787 ABC transporter signature motif; other site 525919000788 Walker B; other site 525919000789 D-loop; other site 525919000790 H-loop/switch region; other site 525919000791 TOBE domain; Region: TOBE_2; cl01440 525919000792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525919000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000794 dimer interface [polypeptide binding]; other site 525919000795 conserved gate region; other site 525919000796 ABC-ATPase subunit interface; other site 525919000797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525919000798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919000799 dimer interface [polypeptide binding]; other site 525919000800 conserved gate region; other site 525919000801 ABC-ATPase subunit interface; other site 525919000802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525919000803 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 525919000804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919000805 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525919000806 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 525919000807 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 525919000808 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 525919000809 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 525919000810 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 525919000811 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 525919000812 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 525919000813 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 525919000814 putative active site [active] 525919000815 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525919000816 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919000817 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 525919000818 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525919000819 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919000820 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 525919000821 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 525919000822 active site 525919000823 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525919000824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919000825 motif II; other site 525919000826 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 525919000827 active site 525919000828 phosphorylation site [posttranslational modification] 525919000829 SdpI/YhfL protein family; Region: SdpI; pfam13630 525919000830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525919000831 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 525919000832 putative ADP-binding pocket [chemical binding]; other site 525919000833 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525919000834 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 525919000835 Helix-turn-helix domains; Region: HTH; cl00088 525919000836 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 525919000837 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 525919000838 Chain length determinant protein; Region: Wzz; cl15801 525919000839 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 525919000840 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 525919000841 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525919000842 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919000843 Walker A/P-loop; other site 525919000844 ATP binding site [chemical binding]; other site 525919000845 Q-loop/lid; other site 525919000846 ABC transporter signature motif; other site 525919000847 Walker B; other site 525919000848 D-loop; other site 525919000849 H-loop/switch region; other site 525919000850 Predicted transcriptional regulators [Transcription]; Region: COG1725 525919000851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919000852 DNA-binding site [nucleotide binding]; DNA binding site 525919000853 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525919000854 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919000855 Walker A/P-loop; other site 525919000856 ATP binding site [chemical binding]; other site 525919000857 Q-loop/lid; other site 525919000858 ABC transporter signature motif; other site 525919000859 Walker B; other site 525919000860 D-loop; other site 525919000861 H-loop/switch region; other site 525919000862 putative lipid kinase; Reviewed; Region: PRK13337 525919000863 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 525919000864 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 525919000865 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 525919000866 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 525919000867 putative active site [active] 525919000868 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 525919000869 substrate binding site; other site 525919000870 dimer interface; other site 525919000871 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 525919000872 homotrimer interaction site [polypeptide binding]; other site 525919000873 zinc binding site [ion binding]; other site 525919000874 CDP-binding sites; other site 525919000875 S-adenosylmethionine synthetase; Validated; Region: PRK05250 525919000876 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525919000877 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 525919000878 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 525919000879 rod shape-determining protein MreB; Provisional; Region: PRK13930 525919000880 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 525919000881 ATP binding site [chemical binding]; other site 525919000882 profilin binding site; other site 525919000883 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 525919000884 catalytic core [active] 525919000885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919000886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919000887 DNA binding site [nucleotide binding] 525919000888 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 525919000889 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 525919000890 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 525919000891 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 525919000892 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 525919000893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525919000894 Coenzyme A binding pocket [chemical binding]; other site 525919000895 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 525919000896 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 525919000897 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 525919000898 active site triad [active] 525919000899 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 525919000900 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 525919000901 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 525919000902 NAD(P) binding site [chemical binding]; other site 525919000903 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 525919000904 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 525919000905 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 525919000906 homotetramer interface [polypeptide binding]; other site 525919000907 FMN binding site [chemical binding]; other site 525919000908 homodimer contacts [polypeptide binding]; other site 525919000909 putative active site [active] 525919000910 putative substrate binding site [chemical binding]; other site 525919000911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919000912 DNA-binding site [nucleotide binding]; DNA binding site 525919000913 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525919000914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919000915 Walker A/P-loop; other site 525919000916 ATP binding site [chemical binding]; other site 525919000917 Q-loop/lid; other site 525919000918 ABC transporter signature motif; other site 525919000919 Walker B; other site 525919000920 D-loop; other site 525919000921 H-loop/switch region; other site 525919000922 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 525919000923 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 525919000924 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 525919000925 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 525919000926 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 525919000927 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525919000928 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525919000929 Peptidase M16C associated; Region: M16C_assoc; pfam08367 525919000930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525919000931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000932 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 525919000933 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525919000934 active pocket/dimerization site; other site 525919000935 active site 525919000936 phosphorylation site [posttranslational modification] 525919000937 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 525919000938 active site 525919000939 phosphorylation site [posttranslational modification] 525919000940 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 525919000941 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 525919000942 Domain of unknown function (DUF956); Region: DUF956; cl01917 525919000943 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 525919000944 elongation factor G; Reviewed; Region: PRK12740 525919000945 G1 box; other site 525919000946 putative GEF interaction site [polypeptide binding]; other site 525919000947 GTP/Mg2+ binding site [chemical binding]; other site 525919000948 Switch I region; other site 525919000949 G2 box; other site 525919000950 G3 box; other site 525919000951 Switch II region; other site 525919000952 G4 box; other site 525919000953 G5 box; other site 525919000954 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525919000955 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 525919000956 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525919000957 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 525919000958 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 525919000959 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 525919000960 active site 525919000961 catalytic site [active] 525919000962 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 525919000963 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 525919000964 active site 525919000965 catalytic triad [active] 525919000966 oxyanion hole [active] 525919000967 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525919000968 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 525919000969 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 525919000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 525919000971 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 525919000972 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 525919000973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919000974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919000975 non-specific DNA binding site [nucleotide binding]; other site 525919000976 salt bridge; other site 525919000977 sequence-specific DNA binding site [nucleotide binding]; other site 525919000978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525919000979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919000980 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919000981 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 525919000982 Walker A/P-loop; other site 525919000983 ATP binding site [chemical binding]; other site 525919000984 Q-loop/lid; other site 525919000985 ABC transporter signature motif; other site 525919000986 Walker B; other site 525919000987 D-loop; other site 525919000988 H-loop/switch region; other site 525919000989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919000990 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919000991 active site 525919000992 motif I; other site 525919000993 motif II; other site 525919000994 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919000995 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919000996 active site 525919000997 motif I; other site 525919000998 motif II; other site 525919000999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919001000 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 525919001001 HPr interaction site; other site 525919001002 glycerol kinase (GK) interaction site [polypeptide binding]; other site 525919001003 active site 525919001004 phosphorylation site [posttranslational modification] 525919001005 hybrid cluster protein; Provisional; Region: PRK05290 525919001006 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525919001007 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 525919001008 hybrid metal cluster; other site 525919001009 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525919001010 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 525919001011 metal binding site [ion binding]; metal-binding site 525919001012 dimer interface [polypeptide binding]; other site 525919001013 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 525919001014 Domain of unknown function (DUF955); Region: DUF955; cl01076 525919001015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919001016 non-specific DNA binding site [nucleotide binding]; other site 525919001017 salt bridge; other site 525919001018 sequence-specific DNA binding site [nucleotide binding]; other site 525919001019 DNA polymerase IV; Reviewed; Region: PRK03103 525919001020 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525919001021 active site 525919001022 DNA binding site [nucleotide binding] 525919001023 Predicted transcriptional regulators [Transcription]; Region: COG1725 525919001024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919001025 DNA-binding site [nucleotide binding]; DNA binding site 525919001026 Predicted membrane protein [General function prediction only]; Region: COG4194 525919001027 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 525919001028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001029 Walker A/P-loop; other site 525919001030 ATP binding site [chemical binding]; other site 525919001031 Q-loop/lid; other site 525919001032 ABC transporter signature motif; other site 525919001033 Walker B; other site 525919001034 D-loop; other site 525919001035 H-loop/switch region; other site 525919001036 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 525919001037 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 525919001038 Malic enzyme, N-terminal domain; Region: malic; pfam00390 525919001039 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 525919001040 putative NAD(P) binding site [chemical binding]; other site 525919001041 Helix-turn-helix domains; Region: HTH; cl00088 525919001042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919001043 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919001044 active site 525919001045 motif I; other site 525919001046 motif II; other site 525919001047 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919001048 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919001049 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 525919001050 Ligand Binding Site [chemical binding]; other site 525919001051 Bacitracin resistance protein BacA; Region: BacA; cl00858 525919001052 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 525919001053 Cupin domain; Region: Cupin_2; cl09118 525919001054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525919001055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525919001056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525919001057 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 525919001058 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 525919001059 catalytic site [active] 525919001060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525919001061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919001062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001063 dimer interface [polypeptide binding]; other site 525919001064 conserved gate region; other site 525919001065 putative PBP binding loops; other site 525919001066 ABC-ATPase subunit interface; other site 525919001067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525919001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001069 dimer interface [polypeptide binding]; other site 525919001070 conserved gate region; other site 525919001071 putative PBP binding loops; other site 525919001072 ABC-ATPase subunit interface; other site 525919001073 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 525919001074 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 525919001075 active site 525919001076 homodimer interface [polypeptide binding]; other site 525919001077 catalytic site [active] 525919001078 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525919001079 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 525919001080 Walker A/P-loop; other site 525919001081 ATP binding site [chemical binding]; other site 525919001082 Q-loop/lid; other site 525919001083 ABC transporter signature motif; other site 525919001084 Walker B; other site 525919001085 D-loop; other site 525919001086 H-loop/switch region; other site 525919001087 TOBE domain; Region: TOBE_2; cl01440 525919001088 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525919001089 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525919001090 Ca binding site [ion binding]; other site 525919001091 active site 525919001092 catalytic site [active] 525919001093 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 525919001094 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 525919001095 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 525919001096 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525919001097 DXD motif; other site 525919001098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525919001099 active site 525919001100 Chain length determinant protein; Region: Wzz; cl15801 525919001101 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 525919001102 Bacterial SH3 domain; Region: SH3_3; cl02551 525919001103 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525919001104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525919001105 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 525919001106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001107 Walker A/P-loop; other site 525919001108 ATP binding site [chemical binding]; other site 525919001109 Q-loop/lid; other site 525919001110 ABC transporter signature motif; other site 525919001111 Walker B; other site 525919001112 D-loop; other site 525919001113 H-loop/switch region; other site 525919001114 TOBE domain; Region: TOBE_2; cl01440 525919001115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001116 dimer interface [polypeptide binding]; other site 525919001117 conserved gate region; other site 525919001118 putative PBP binding loops; other site 525919001119 ABC-ATPase subunit interface; other site 525919001120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525919001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001122 dimer interface [polypeptide binding]; other site 525919001123 conserved gate region; other site 525919001124 putative PBP binding loops; other site 525919001125 ABC-ATPase subunit interface; other site 525919001126 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525919001127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919001128 Amidinotransferase; Region: Amidinotransf; cl12043 525919001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919001130 S-adenosylmethionine binding site [chemical binding]; other site 525919001131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525919001132 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919001133 uracil transporter; Provisional; Region: PRK10720 525919001134 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 525919001135 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525919001136 C-terminal peptidase (prc); Region: prc; TIGR00225 525919001137 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 525919001138 protein binding site [polypeptide binding]; other site 525919001139 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 525919001140 Catalytic dyad [active] 525919001141 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 525919001142 MgtE intracellular N domain; Region: MgtE_N; cl15244 525919001143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 525919001144 Divalent cation transporter; Region: MgtE; cl00786 525919001145 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525919001146 active site 2 [active] 525919001147 active site 1 [active] 525919001148 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525919001149 active site 1 [active] 525919001150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 525919001151 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 525919001152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919001153 FeS/SAM binding site; other site 525919001154 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 525919001155 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 525919001156 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 525919001157 G1 box; other site 525919001158 GTP/Mg2+ binding site [chemical binding]; other site 525919001159 Switch I region; other site 525919001160 G2 box; other site 525919001161 Switch II region; other site 525919001162 G3 box; other site 525919001163 G4 box; other site 525919001164 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 525919001165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919001166 FeS/SAM binding site; other site 525919001167 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 525919001168 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 525919001169 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 525919001170 Walker A/P-loop; other site 525919001171 ATP binding site [chemical binding]; other site 525919001172 Q-loop/lid; other site 525919001173 ABC transporter signature motif; other site 525919001174 Walker B; other site 525919001175 D-loop; other site 525919001176 H-loop/switch region; other site 525919001177 NIL domain; Region: NIL; cl09633 525919001178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001179 dimer interface [polypeptide binding]; other site 525919001180 conserved gate region; other site 525919001181 ABC-ATPase subunit interface; other site 525919001182 NMT1-like family; Region: NMT1_2; cl15260 525919001183 NMT1-like family; Region: NMT1_2; cl15260 525919001184 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919001185 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525919001186 Homoserine O-succinyltransferase; Region: HTS; pfam04204 525919001187 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 525919001188 proposed active site lysine [active] 525919001189 conserved cys residue [active] 525919001190 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 525919001191 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 525919001192 homodimer interface [polypeptide binding]; other site 525919001193 substrate-cofactor binding pocket; other site 525919001194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919001195 catalytic residue [active] 525919001196 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 525919001197 catalytic residues [active] 525919001198 dimer interface [polypeptide binding]; other site 525919001199 AMMECR1; Region: AMMECR1; cl00911 525919001200 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 525919001201 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525919001202 active site 525919001203 HIGH motif; other site 525919001204 nucleotide binding site [chemical binding]; other site 525919001205 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525919001206 active site 525919001207 KMSKS motif; other site 525919001208 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 525919001209 tRNA binding surface [nucleotide binding]; other site 525919001210 anticodon binding site; other site 525919001211 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 525919001212 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 525919001213 putative active site [active] 525919001214 nucleotide binding site [chemical binding]; other site 525919001215 nudix motif; other site 525919001216 putative metal binding site [ion binding]; other site 525919001217 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919001218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919001219 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919001220 Walker A/P-loop; other site 525919001221 ATP binding site [chemical binding]; other site 525919001222 Q-loop/lid; other site 525919001223 ABC transporter signature motif; other site 525919001224 Walker B; other site 525919001225 D-loop; other site 525919001226 H-loop/switch region; other site 525919001227 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 525919001228 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525919001229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525919001230 FtsX-like permease family; Region: FtsX; cl15850 525919001231 ATP cone domain; Region: ATP-cone; pfam03477 525919001232 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 525919001233 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 525919001234 DJ-1 family protein; Region: not_thiJ; TIGR01383 525919001235 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 525919001236 conserved cys residue [active] 525919001237 Predicted dehydrogenase [General function prediction only]; Region: COG0579 525919001238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919001239 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 525919001240 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 525919001241 amphipathic channel; other site 525919001242 Asn-Pro-Ala signature motifs; other site 525919001243 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 525919001244 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 525919001245 ligand binding site [chemical binding]; other site 525919001246 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 525919001247 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 525919001248 Walker A/P-loop; other site 525919001249 ATP binding site [chemical binding]; other site 525919001250 Q-loop/lid; other site 525919001251 ABC transporter signature motif; other site 525919001252 Walker B; other site 525919001253 D-loop; other site 525919001254 H-loop/switch region; other site 525919001255 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 525919001256 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525919001257 TM-ABC transporter signature motif; other site 525919001258 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525919001259 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525919001260 TM-ABC transporter signature motif; other site 525919001261 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 525919001262 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 525919001263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919001264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919001265 catalytic residue [active] 525919001266 OpgC protein; Region: OpgC_C; cl00792 525919001267 Acyltransferase family; Region: Acyl_transf_3; pfam01757 525919001268 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 525919001269 active site 525919001270 catalytic triad [active] 525919001271 oxyanion hole [active] 525919001272 Bacterial SH3 domain; Region: SH3_3; cl02551 525919001273 NlpC/P60 family; Region: NLPC_P60; cl11438 525919001274 Glutaminase; Region: Glutaminase; cl00907 525919001275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525919001276 putative substrate translocation pore; other site 525919001277 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919001278 MatE; Region: MatE; cl10513 525919001279 MatE; Region: MatE; cl10513 525919001280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525919001281 Coenzyme A binding pocket [chemical binding]; other site 525919001282 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 525919001283 active site 525919001284 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 525919001285 Predicted membrane protein [Function unknown]; Region: COG4129 525919001286 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 525919001287 CpXC protein; Region: CpXC; pfam14353 525919001288 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 525919001289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919001290 FeS/SAM binding site; other site 525919001291 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 525919001292 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 525919001293 metal binding site [ion binding]; metal-binding site 525919001294 dimer interface [polypeptide binding]; other site 525919001295 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919001296 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 525919001297 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919001298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 525919001299 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 525919001300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 525919001301 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 525919001302 AzlC protein; Region: AzlC; cl00570 525919001303 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 525919001304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525919001305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919001306 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 525919001307 Vps51/Vps67; Region: Vps51; cl15380 525919001308 Reticulon; Region: Reticulon; pfam02453 525919001309 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 525919001310 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 525919001311 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 525919001312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001313 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 525919001314 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 525919001315 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 525919001316 active site 525919001317 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 525919001318 active site 525919001319 catalytic motif [active] 525919001320 Zn binding site [ion binding]; other site 525919001321 GTPase Era; Reviewed; Region: era; PRK00089 525919001322 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 525919001323 G1 box; other site 525919001324 GTP/Mg2+ binding site [chemical binding]; other site 525919001325 Switch I region; other site 525919001326 G2 box; other site 525919001327 Switch II region; other site 525919001328 G3 box; other site 525919001329 G4 box; other site 525919001330 G5 box; other site 525919001331 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 525919001332 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 525919001333 Recombination protein O N terminal; Region: RecO_N; cl15812 525919001334 Recombination protein O C terminal; Region: RecO_C; pfam02565 525919001335 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 525919001336 dimer interface [polypeptide binding]; other site 525919001337 motif 1; other site 525919001338 active site 525919001339 motif 2; other site 525919001340 motif 3; other site 525919001341 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 525919001342 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525919001343 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 525919001344 GMP synthase; Reviewed; Region: guaA; PRK00074 525919001345 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 525919001346 AMP/PPi binding site [chemical binding]; other site 525919001347 candidate oxyanion hole; other site 525919001348 catalytic triad [active] 525919001349 potential glutamine specificity residues [chemical binding]; other site 525919001350 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 525919001351 ATP Binding subdomain [chemical binding]; other site 525919001352 Ligand Binding sites [chemical binding]; other site 525919001353 Dimerization subdomain; other site 525919001354 Virulence protein [General function prediction only]; Region: COG3943 525919001355 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 525919001356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919001357 non-specific DNA binding site [nucleotide binding]; other site 525919001358 salt bridge; other site 525919001359 sequence-specific DNA binding site [nucleotide binding]; other site 525919001360 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 525919001361 KilA-N domain; Region: KilA-N; pfam04383 525919001362 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 525919001363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525919001364 Helix-turn-helix domains; Region: HTH; cl00088 525919001365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919001366 dimerization interface [polypeptide binding]; other site 525919001367 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 525919001368 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 525919001369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919001370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919001371 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 525919001373 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 525919001374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001375 AAA-like domain; Region: AAA_10; pfam12846 525919001376 Walker A motif; other site 525919001377 ATP binding site [chemical binding]; other site 525919001378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919001379 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525919001380 Walker A motif; other site 525919001381 ATP binding site [chemical binding]; other site 525919001382 Walker B motif; other site 525919001383 arginine finger; other site 525919001384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525919001385 dimerization interface [polypeptide binding]; other site 525919001386 putative DNA binding site [nucleotide binding]; other site 525919001387 putative Zn2+ binding site [ion binding]; other site 525919001388 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 525919001389 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 525919001390 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 525919001391 P loop; other site 525919001392 Nucleotide binding site [chemical binding]; other site 525919001393 DTAP/Switch II; other site 525919001394 Switch I; other site 525919001395 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 525919001396 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 525919001397 P loop; other site 525919001398 Nucleotide binding site [chemical binding]; other site 525919001399 DTAP/Switch II; other site 525919001400 Switch I; other site 525919001401 Low molecular weight phosphatase family; Region: LMWPc; cd00115 525919001402 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 525919001403 active site 525919001404 Membrane transport protein; Region: Mem_trans; cl09117 525919001405 phenylhydantoinase; Validated; Region: PRK08323 525919001406 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 525919001407 active site 525919001408 tetramer interface [polypeptide binding]; other site 525919001409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 525919001410 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 525919001411 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 525919001412 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 525919001413 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 525919001414 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 525919001415 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 525919001416 Ligand binding site; other site 525919001417 metal-binding site 525919001418 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 525919001419 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 525919001420 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 525919001421 XdhC Rossmann domain; Region: XdhC_C; pfam13478 525919001422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525919001423 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 525919001424 dimer interface [polypeptide binding]; other site 525919001425 active site 525919001426 metal binding site [ion binding]; metal-binding site 525919001427 glutathione binding site [chemical binding]; other site 525919001428 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 525919001429 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919001430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919001431 catalytic residue [active] 525919001432 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 525919001433 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 525919001434 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 525919001435 CPxP motif; other site 525919001436 DsrE/DsrF-like family; Region: DrsE; cl00672 525919001437 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 525919001438 selenophosphate synthetase; Provisional; Region: PRK00943 525919001439 dimerization interface [polypeptide binding]; other site 525919001440 putative ATP binding site [chemical binding]; other site 525919001441 TIGR00159 family protein; Region: TIGR00159 525919001442 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 525919001443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 525919001444 YbbR-like protein; Region: YbbR; pfam07949 525919001445 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525919001446 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 525919001447 active site 525919001448 NTP binding site [chemical binding]; other site 525919001449 metal binding triad [ion binding]; metal-binding site 525919001450 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525919001451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 525919001452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 525919001453 trigger factor; Provisional; Region: tig; PRK01490 525919001454 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 525919001455 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 525919001456 Clp protease; Region: CLP_protease; pfam00574 525919001457 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525919001458 oligomer interface [polypeptide binding]; other site 525919001459 active site residues [active] 525919001460 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 525919001461 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 525919001462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919001463 Walker A motif; other site 525919001464 ATP binding site [chemical binding]; other site 525919001465 Walker B motif; other site 525919001466 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 525919001467 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 525919001468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919001469 Walker A motif; other site 525919001470 ATP binding site [chemical binding]; other site 525919001471 Walker B motif; other site 525919001472 arginine finger; other site 525919001473 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 525919001474 Predicted GTPase [General function prediction only]; Region: COG0218 525919001475 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 525919001476 G1 box; other site 525919001477 GTP/Mg2+ binding site [chemical binding]; other site 525919001478 Switch I region; other site 525919001479 G2 box; other site 525919001480 G3 box; other site 525919001481 Switch II region; other site 525919001482 G4 box; other site 525919001483 G5 box; other site 525919001484 FMN-binding domain; Region: FMN_bind; cl01081 525919001485 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 525919001486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919001487 CutC family; Region: CutC; cl01218 525919001488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919001489 active site 525919001490 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 525919001491 Helix-turn-helix domains; Region: HTH; cl00088 525919001492 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 525919001493 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 525919001494 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 525919001495 putative substrate binding site [chemical binding]; other site 525919001496 putative ATP binding site [chemical binding]; other site 525919001497 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 525919001498 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525919001499 active site 525919001500 phosphorylation site [posttranslational modification] 525919001501 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 525919001502 P-loop; other site 525919001503 active site 525919001504 phosphorylation site [posttranslational modification] 525919001505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919001506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525919001507 Quinolinate synthetase A protein; Region: NadA; cl00420 525919001508 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 525919001509 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 525919001510 active site 525919001511 metal binding site [ion binding]; metal-binding site 525919001512 Domain of unknown function DUF77; Region: DUF77; cl00307 525919001513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525919001514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525919001515 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525919001516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001517 dimer interface [polypeptide binding]; other site 525919001518 conserved gate region; other site 525919001519 putative PBP binding loops; other site 525919001520 ABC-ATPase subunit interface; other site 525919001521 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 525919001522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001523 dimer interface [polypeptide binding]; other site 525919001524 conserved gate region; other site 525919001525 putative PBP binding loops; other site 525919001526 ABC-ATPase subunit interface; other site 525919001527 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525919001528 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919001529 Walker A/P-loop; other site 525919001530 ATP binding site [chemical binding]; other site 525919001531 Q-loop/lid; other site 525919001532 ABC transporter signature motif; other site 525919001533 Walker B; other site 525919001534 D-loop; other site 525919001535 H-loop/switch region; other site 525919001536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525919001537 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919001538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 525919001539 Walker A/P-loop; other site 525919001540 ATP binding site [chemical binding]; other site 525919001541 Q-loop/lid; other site 525919001542 ABC transporter signature motif; other site 525919001543 Walker B; other site 525919001544 D-loop; other site 525919001545 H-loop/switch region; other site 525919001546 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 525919001547 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525919001548 Domain of unknown function DUF21; Region: DUF21; pfam01595 525919001549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525919001550 Transporter associated domain; Region: CorC_HlyC; cl08393 525919001551 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 525919001552 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525919001553 DRTGG domain; Region: DRTGG; cl12147 525919001554 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525919001555 DHHA2 domain; Region: DHHA2; pfam02833 525919001556 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525919001557 nudix motif; other site 525919001558 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525919001559 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919001560 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 525919001561 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 525919001562 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 525919001563 heat shock protein 90; Provisional; Region: PRK05218 525919001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 525919001565 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 525919001566 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 525919001567 oligomer interface [polypeptide binding]; other site 525919001568 putative active site [active] 525919001569 metal binding site [ion binding]; metal-binding site 525919001570 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 525919001571 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 525919001572 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 525919001573 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525919001574 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919001575 Walker A/P-loop; other site 525919001576 ATP binding site [chemical binding]; other site 525919001577 Q-loop/lid; other site 525919001578 ABC transporter signature motif; other site 525919001579 Walker B; other site 525919001580 D-loop; other site 525919001581 H-loop/switch region; other site 525919001582 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 525919001583 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 525919001584 active site 525919001585 Zn binding site [ion binding]; other site 525919001586 Thiamine pyrophosphokinase; Region: TPK; cd07995 525919001587 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 525919001588 active site 525919001589 dimerization interface [polypeptide binding]; other site 525919001590 thiamine binding site [chemical binding]; other site 525919001591 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525919001592 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 525919001593 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 525919001594 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 525919001595 homodimer interface [polypeptide binding]; other site 525919001596 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 525919001597 active site pocket [active] 525919001598 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 525919001599 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 525919001600 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 525919001601 Ligand binding site; other site 525919001602 metal-binding site 525919001603 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 525919001604 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919001605 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 525919001606 Walker A/P-loop; other site 525919001607 ATP binding site [chemical binding]; other site 525919001608 Q-loop/lid; other site 525919001609 ABC transporter signature motif; other site 525919001610 Walker B; other site 525919001611 D-loop; other site 525919001612 H-loop/switch region; other site 525919001613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919001614 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919001615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001616 Walker A/P-loop; other site 525919001617 ATP binding site [chemical binding]; other site 525919001618 Q-loop/lid; other site 525919001619 ABC transporter signature motif; other site 525919001620 Walker B; other site 525919001621 D-loop; other site 525919001622 H-loop/switch region; other site 525919001623 Helix-turn-helix domains; Region: HTH; cl00088 525919001624 Transcriptional regulators [Transcription]; Region: MarR; COG1846 525919001625 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 525919001626 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 525919001627 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919001628 MatE; Region: MatE; cl10513 525919001629 MatE; Region: MatE; cl10513 525919001630 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 525919001631 substrate binding site [chemical binding]; other site 525919001632 ATP binding site [chemical binding]; other site 525919001633 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 525919001634 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 525919001635 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 525919001636 putative active site [active] 525919001637 catalytic site [active] 525919001638 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 525919001639 putative active site [active] 525919001640 catalytic site [active] 525919001641 Predicted transcriptional regulators [Transcription]; Region: COG1725 525919001642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919001643 DNA-binding site [nucleotide binding]; DNA binding site 525919001644 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525919001645 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919001646 Walker A/P-loop; other site 525919001647 ATP binding site [chemical binding]; other site 525919001648 Q-loop/lid; other site 525919001649 ABC transporter signature motif; other site 525919001650 Walker B; other site 525919001651 D-loop; other site 525919001652 H-loop/switch region; other site 525919001653 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 525919001654 catalytic motif [active] 525919001655 Zn binding site [ion binding]; other site 525919001656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919001657 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919001658 active site 525919001659 motif I; other site 525919001660 motif II; other site 525919001661 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 525919001662 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 525919001663 putative substrate binding site [chemical binding]; other site 525919001664 putative ATP binding site [chemical binding]; other site 525919001665 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525919001666 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 525919001667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919001668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525919001669 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 525919001670 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 525919001671 ATP-grasp domain; Region: ATP-grasp_4; cl03087 525919001672 Bacterial SH3 domain; Region: SH3_3; cl02551 525919001673 Bacterial SH3 domain; Region: SH3_3; cl02551 525919001674 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 525919001675 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 525919001676 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 525919001677 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 525919001678 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 525919001679 active site 525919001680 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 525919001681 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 525919001682 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525919001683 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 525919001684 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525919001685 FMN binding site [chemical binding]; other site 525919001686 dimer interface [polypeptide binding]; other site 525919001687 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 525919001688 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 525919001689 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 525919001690 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525919001691 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525919001692 RPB1 interaction site [polypeptide binding]; other site 525919001693 RPB10 interaction site [polypeptide binding]; other site 525919001694 RPB11 interaction site [polypeptide binding]; other site 525919001695 RPB3 interaction site [polypeptide binding]; other site 525919001696 RPB12 interaction site [polypeptide binding]; other site 525919001697 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 525919001698 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 525919001699 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 525919001700 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 525919001701 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 525919001702 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 525919001703 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 525919001704 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 525919001705 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525919001706 DNA binding site [nucleotide binding] 525919001707 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 525919001708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525919001709 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 525919001710 active site 525919001711 catalytic tetrad [active] 525919001712 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 525919001713 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 525919001714 Cl- selectivity filter; other site 525919001715 Cl- binding residues [ion binding]; other site 525919001716 pore gating glutamate residue; other site 525919001717 dimer interface [polypeptide binding]; other site 525919001718 H+/Cl- coupling transport residue; other site 525919001719 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 525919001720 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919001721 MatE; Region: MatE; cl10513 525919001722 MatE; Region: MatE; cl10513 525919001723 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 525919001724 dimer interface [polypeptide binding]; other site 525919001725 catalytic triad [active] 525919001726 peroxidatic and resolving cysteines [active] 525919001727 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919001728 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 525919001729 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525919001730 active site turn [active] 525919001731 phosphorylation site [posttranslational modification] 525919001732 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 525919001733 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 525919001734 NAD binding site [chemical binding]; other site 525919001735 sugar binding site [chemical binding]; other site 525919001736 divalent metal binding site [ion binding]; other site 525919001737 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 525919001738 dimer interface [polypeptide binding]; other site 525919001739 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 525919001740 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 525919001741 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 525919001742 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 525919001743 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 525919001744 putative active site [active] 525919001745 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 525919001746 S17 interaction site [polypeptide binding]; other site 525919001747 S8 interaction site; other site 525919001748 16S rRNA interaction site [nucleotide binding]; other site 525919001749 streptomycin interaction site [chemical binding]; other site 525919001750 23S rRNA interaction site [nucleotide binding]; other site 525919001751 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 525919001752 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 525919001753 elongation factor G; Reviewed; Region: PRK00007 525919001754 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525919001755 G1 box; other site 525919001756 putative GEF interaction site [polypeptide binding]; other site 525919001757 GTP/Mg2+ binding site [chemical binding]; other site 525919001758 Switch I region; other site 525919001759 G2 box; other site 525919001760 G3 box; other site 525919001761 Switch II region; other site 525919001762 G4 box; other site 525919001763 G5 box; other site 525919001764 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525919001765 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525919001766 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525919001767 elongation factor Tu; Reviewed; Region: PRK00049 525919001768 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525919001769 G1 box; other site 525919001770 GEF interaction site [polypeptide binding]; other site 525919001771 GTP/Mg2+ binding site [chemical binding]; other site 525919001772 Switch I region; other site 525919001773 G2 box; other site 525919001774 G3 box; other site 525919001775 Switch II region; other site 525919001776 G4 box; other site 525919001777 G5 box; other site 525919001778 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525919001779 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525919001780 Antibiotic Binding Site [chemical binding]; other site 525919001781 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919001782 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525919001783 intersubunit interface [polypeptide binding]; other site 525919001784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919001785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919001786 Walker A/P-loop; other site 525919001787 ATP binding site [chemical binding]; other site 525919001788 Q-loop/lid; other site 525919001789 ABC transporter signature motif; other site 525919001790 Walker B; other site 525919001791 D-loop; other site 525919001792 H-loop/switch region; other site 525919001793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919001794 ABC-ATPase subunit interface; other site 525919001795 dimer interface [polypeptide binding]; other site 525919001796 putative PBP binding regions; other site 525919001797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525919001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001799 dimer interface [polypeptide binding]; other site 525919001800 conserved gate region; other site 525919001801 putative PBP binding loops; other site 525919001802 ABC-ATPase subunit interface; other site 525919001803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525919001804 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 525919001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001806 dimer interface [polypeptide binding]; other site 525919001807 conserved gate region; other site 525919001808 putative PBP binding loops; other site 525919001809 ABC-ATPase subunit interface; other site 525919001810 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525919001811 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919001812 Walker A/P-loop; other site 525919001813 ATP binding site [chemical binding]; other site 525919001814 Q-loop/lid; other site 525919001815 ABC transporter signature motif; other site 525919001816 Walker B; other site 525919001817 D-loop; other site 525919001818 H-loop/switch region; other site 525919001819 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525919001820 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 525919001821 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919001822 Walker A/P-loop; other site 525919001823 ATP binding site [chemical binding]; other site 525919001824 Q-loop/lid; other site 525919001825 ABC transporter signature motif; other site 525919001826 Walker B; other site 525919001827 D-loop; other site 525919001828 H-loop/switch region; other site 525919001829 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525919001830 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525919001831 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 525919001832 peptide binding site [polypeptide binding]; other site 525919001833 EamA-like transporter family; Region: EamA; cl01037 525919001834 EamA-like transporter family; Region: EamA; cl01037 525919001835 Uncharacterized membrane protein [Function unknown]; Region: COG3949 525919001836 Domain of unknown function (DUF1771); Region: DUF1771; pfam08590 525919001837 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525919001838 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 525919001839 active site turn [active] 525919001840 phosphorylation site [posttranslational modification] 525919001841 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919001842 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525919001843 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525919001844 Ca binding site [ion binding]; other site 525919001845 active site 525919001846 catalytic site [active] 525919001847 A2L zinc ribbon domain; Region: A2L_zn_ribbon; pfam08792 525919001848 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 525919001849 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 525919001850 Short C-terminal domain; Region: SHOCT; cl01373 525919001851 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919001852 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919001853 Walker A/P-loop; other site 525919001854 ATP binding site [chemical binding]; other site 525919001855 Q-loop/lid; other site 525919001856 ABC transporter signature motif; other site 525919001857 Walker B; other site 525919001858 D-loop; other site 525919001859 H-loop/switch region; other site 525919001860 FtsX-like permease family; Region: FtsX; cl15850 525919001861 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525919001862 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919001863 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 525919001864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 525919001865 phosphate binding site [ion binding]; other site 525919001866 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 525919001867 putative active site pocket [active] 525919001868 cleavage site 525919001869 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 525919001870 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525919001871 dimer interface [polypeptide binding]; other site 525919001872 ssDNA binding site [nucleotide binding]; other site 525919001873 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525919001874 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 525919001875 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 525919001876 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 525919001877 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 525919001878 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 525919001879 ANP binding site [chemical binding]; other site 525919001880 Substrate Binding Site II [chemical binding]; other site 525919001881 Substrate Binding Site I [chemical binding]; other site 525919001882 argininosuccinate lyase; Provisional; Region: PRK00855 525919001883 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 525919001884 active sites [active] 525919001885 tetramer interface [polypeptide binding]; other site 525919001886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525919001887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525919001888 substrate binding pocket [chemical binding]; other site 525919001889 membrane-bound complex binding site; other site 525919001890 hinge residues; other site 525919001891 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525919001892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919001893 dimer interface [polypeptide binding]; other site 525919001894 conserved gate region; other site 525919001895 putative PBP binding loops; other site 525919001896 ABC-ATPase subunit interface; other site 525919001897 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525919001898 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 525919001899 Walker A/P-loop; other site 525919001900 ATP binding site [chemical binding]; other site 525919001901 Q-loop/lid; other site 525919001902 ABC transporter signature motif; other site 525919001903 Walker B; other site 525919001904 D-loop; other site 525919001905 H-loop/switch region; other site 525919001906 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 525919001907 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 525919001908 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525919001909 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 525919001910 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 525919001911 polyphosphate kinase; Provisional; Region: PRK05443 525919001912 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 525919001913 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 525919001914 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 525919001915 putative active site [active] 525919001916 catalytic site [active] 525919001917 Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169 525919001918 putative domain interface [polypeptide binding]; other site 525919001919 putative active site [active] 525919001920 catalytic site [active] 525919001921 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 525919001922 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 525919001923 homotrimer interaction site [polypeptide binding]; other site 525919001924 putative active site [active] 525919001925 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525919001926 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525919001927 metal binding site [ion binding]; metal-binding site 525919001928 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525919001929 YodA lipocalin-like domain; Region: YodA; cl01365 525919001930 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919001931 intersubunit interface [polypeptide binding]; other site 525919001932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919001933 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525919001934 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 525919001935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919001936 ABC-ATPase subunit interface; other site 525919001937 dimer interface [polypeptide binding]; other site 525919001938 putative PBP binding regions; other site 525919001939 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 525919001940 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 525919001941 NAD(P) binding site [chemical binding]; other site 525919001942 catalytic residues [active] 525919001943 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 525919001944 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919001945 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 525919001946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 525919001947 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 525919001948 FAD binding site [chemical binding]; other site 525919001949 homotetramer interface [polypeptide binding]; other site 525919001950 substrate binding pocket [chemical binding]; other site 525919001951 catalytic base [active] 525919001952 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 525919001953 TIR domain; Region: TIR_2; cl15770 525919001954 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 525919001955 multimer interface [polypeptide binding]; other site 525919001956 NAD synthetase; Reviewed; Region: nadE; PRK02628 525919001957 active site 525919001958 catalytic triad [active] 525919001959 protein interface 1 [polypeptide binding]; other site 525919001960 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 525919001961 homodimer interface [polypeptide binding]; other site 525919001962 NAD binding pocket [chemical binding]; other site 525919001963 ATP binding pocket [chemical binding]; other site 525919001964 Mg binding site [ion binding]; other site 525919001965 active-site loop [active] 525919001966 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 525919001967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525919001968 putative active site [active] 525919001969 putative metal binding site [ion binding]; other site 525919001970 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 525919001971 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 525919001972 NADP binding site [chemical binding]; other site 525919001973 active site 525919001974 putative substrate binding site [chemical binding]; other site 525919001975 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525919001976 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919001977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919001978 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 525919001979 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525919001980 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525919001981 metal binding site 2 [ion binding]; metal-binding site 525919001982 putative DNA binding helix; other site 525919001983 metal binding site 1 [ion binding]; metal-binding site 525919001984 dimer interface [polypeptide binding]; other site 525919001985 structural Zn2+ binding site [ion binding]; other site 525919001986 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919001987 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525919001988 intersubunit interface [polypeptide binding]; other site 525919001989 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525919001990 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 525919001991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 525919001992 ABC-ATPase subunit interface; other site 525919001993 dimer interface [polypeptide binding]; other site 525919001994 putative PBP binding regions; other site 525919001995 Protein of unknown function (DUF328); Region: DUF328; cl01143 525919001996 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 525919001997 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 525919001998 active site 525919001999 metal binding site [ion binding]; metal-binding site 525919002000 DNA binding site [nucleotide binding] 525919002001 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 525919002002 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 525919002003 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 525919002004 Walker A/P-loop; other site 525919002005 ATP binding site [chemical binding]; other site 525919002006 Q-loop/lid; other site 525919002007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002008 Walker B; other site 525919002009 D-loop; other site 525919002010 H-loop/switch region; other site 525919002011 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 525919002012 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 525919002013 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 525919002014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002016 Family description; Region: UvrD_C_2; cl15862 525919002017 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 525919002018 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525919002019 active site 525919002020 metal binding site [ion binding]; metal-binding site 525919002021 NMT1-like family; Region: NMT1_2; cl15260 525919002022 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 525919002023 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525919002024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919002025 dimer interface [polypeptide binding]; other site 525919002026 conserved gate region; other site 525919002027 putative PBP binding loops; other site 525919002028 ABC-ATPase subunit interface; other site 525919002029 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525919002030 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 525919002031 Walker A/P-loop; other site 525919002032 ATP binding site [chemical binding]; other site 525919002033 Q-loop/lid; other site 525919002034 ABC transporter signature motif; other site 525919002035 Walker B; other site 525919002036 D-loop; other site 525919002037 H-loop/switch region; other site 525919002038 Cytochrome c552; Region: Cytochrom_C552; pfam02335 525919002039 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 525919002040 ResB-like family; Region: ResB; pfam05140 525919002041 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 525919002042 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 525919002043 nucleotidyl binding site; other site 525919002044 metal binding site [ion binding]; metal-binding site 525919002045 DHH family; Region: DHH; pfam01368 525919002046 DHHA1 domain; Region: DHHA1; pfam02272 525919002047 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 525919002048 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 525919002049 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 525919002050 replicative DNA helicase; Region: DnaB; TIGR00665 525919002051 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 525919002052 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 525919002053 Walker A motif; other site 525919002054 ATP binding site [chemical binding]; other site 525919002055 Walker B motif; other site 525919002056 DNA binding loops [nucleotide binding] 525919002057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525919002058 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919002059 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 525919002060 DNA replication protein DnaC; Validated; Region: PRK06835 525919002061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919002062 Walker A motif; other site 525919002063 ATP binding site [chemical binding]; other site 525919002064 Walker B motif; other site 525919002065 arginine finger; other site 525919002066 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 525919002067 Chain length determinant protein; Region: Wzz; cl15801 525919002068 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 525919002069 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 525919002070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002071 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 525919002072 Bacterial SH3 domain; Region: SH3_3; cl02551 525919002073 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 525919002074 classical (c) SDRs; Region: SDR_c; cd05233 525919002075 NAD(P) binding site [chemical binding]; other site 525919002076 active site 525919002077 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 525919002078 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 525919002079 active site 525919002080 catalytic tetrad [active] 525919002081 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 525919002082 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 525919002083 tetramer interface [polypeptide binding]; other site 525919002084 heme binding pocket [chemical binding]; other site 525919002085 NADPH binding site [chemical binding]; other site 525919002086 Helix-turn-helix domains; Region: HTH; cl00088 525919002087 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 525919002088 Protein export membrane protein; Region: SecD_SecF; cl14618 525919002089 Protein export membrane protein; Region: SecD_SecF; cl14618 525919002090 Predicted membrane protein [Function unknown]; Region: COG1511 525919002091 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 525919002092 putative oxidoreductase; Provisional; Region: PRK12831 525919002093 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525919002094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919002095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525919002096 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 525919002097 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 525919002098 FAD binding pocket [chemical binding]; other site 525919002099 FAD binding motif [chemical binding]; other site 525919002100 phosphate binding motif [ion binding]; other site 525919002101 beta-alpha-beta structure motif; other site 525919002102 NAD binding pocket [chemical binding]; other site 525919002103 Iron coordination center [ion binding]; other site 525919002104 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919002105 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919002106 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 525919002107 Walker A/P-loop; other site 525919002108 ATP binding site [chemical binding]; other site 525919002109 Q-loop/lid; other site 525919002110 ABC transporter signature motif; other site 525919002111 Walker B; other site 525919002112 D-loop; other site 525919002113 H-loop/switch region; other site 525919002114 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525919002115 HSP70 interaction site [polypeptide binding]; other site 525919002116 Uncharacterized conserved protein [Function unknown]; Region: COG2966 525919002117 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 525919002118 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 525919002119 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 525919002120 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 525919002121 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 525919002122 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 525919002123 active site 525919002124 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 525919002125 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 525919002126 MG2 domain; Region: A2M_N; pfam01835 525919002127 MG2 domain; Region: A2M_N; pfam01835 525919002128 MG2 domain; Region: A2M_N; pfam01835 525919002129 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 525919002130 Helix-turn-helix domains; Region: HTH; cl00088 525919002131 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 525919002132 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525919002133 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919002134 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 525919002135 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 525919002136 active site 525919002137 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 525919002138 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 525919002139 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919002140 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 525919002141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919002142 catalytic residue [active] 525919002143 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 525919002144 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 525919002145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919002146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919002147 non-specific DNA binding site [nucleotide binding]; other site 525919002148 salt bridge; other site 525919002149 replication factor C small subunit; Provisional; Region: PRK04132 525919002150 sequence-specific DNA binding site [nucleotide binding]; other site 525919002151 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 525919002152 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 525919002153 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 525919002154 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 525919002155 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 525919002156 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 525919002157 Type III pantothenate kinase; Region: Pan_kinase; cl09130 525919002158 Predicted membrane protein [Function unknown]; Region: COG4684 525919002159 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 525919002160 OpgC protein; Region: OpgC_C; cl00792 525919002161 Acyltransferase family; Region: Acyl_transf_3; pfam01757 525919002162 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 525919002163 active site 525919002164 catalytic triad [active] 525919002165 oxyanion hole [active] 525919002166 seryl-tRNA synthetase; Provisional; Region: PRK05431 525919002167 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 525919002168 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 525919002169 motif 1; other site 525919002170 dimer interface [polypeptide binding]; other site 525919002171 active site 525919002172 motif 2; other site 525919002173 motif 3; other site 525919002174 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 525919002175 active site 525919002176 DNA binding site [nucleotide binding] 525919002177 putative phosphate binding site [ion binding]; other site 525919002178 putative catalytic site [active] 525919002179 metal binding site A [ion binding]; metal-binding site 525919002180 AP binding site [nucleotide binding]; other site 525919002181 metal binding site B [ion binding]; metal-binding site 525919002182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525919002183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525919002184 RNA binding surface [nucleotide binding]; other site 525919002185 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 525919002186 active site 525919002187 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 525919002188 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 525919002189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002190 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 525919002191 Type II/IV secretion system protein; Region: T2SE; pfam00437 525919002192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002193 Walker A motif; other site 525919002194 ATP binding site [chemical binding]; other site 525919002195 Walker B motif; other site 525919002196 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 525919002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919002198 non-specific DNA binding site [nucleotide binding]; other site 525919002199 salt bridge; other site 525919002200 sequence-specific DNA binding site [nucleotide binding]; other site 525919002201 Phage terminase, small subunit; Region: Terminase_4; cl01525 525919002202 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 525919002203 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 525919002204 catalytic residue [active] 525919002205 putative FPP diphosphate binding site; other site 525919002206 putative FPP binding hydrophobic cleft; other site 525919002207 dimer interface [polypeptide binding]; other site 525919002208 putative IPP diphosphate binding site; other site 525919002209 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 525919002210 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 525919002211 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 525919002212 active site 525919002213 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 525919002214 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 525919002215 putative substrate binding region [chemical binding]; other site 525919002216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 525919002217 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525919002218 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525919002219 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 525919002220 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 525919002221 generic binding surface II; other site 525919002222 generic binding surface I; other site 525919002223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525919002224 active site 525919002225 substrate binding site [chemical binding]; other site 525919002226 catalytic site [active] 525919002227 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 525919002228 G5 domain; Region: G5; pfam07501 525919002229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 525919002230 metal ion-dependent adhesion site (MIDAS); other site 525919002231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002232 Carbon starvation protein CstA; Region: CstA; pfam02554 525919002233 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 525919002234 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 525919002235 ribosome maturation protein RimP; Reviewed; Region: PRK00092 525919002236 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 525919002237 NusA N-terminal domain; Region: NusA_N; pfam08529 525919002238 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 525919002239 RNA binding site [nucleotide binding]; other site 525919002240 homodimer interface [polypeptide binding]; other site 525919002241 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 525919002242 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525919002243 G-X-X-G motif; other site 525919002244 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 525919002245 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525919002246 translation initiation factor IF-2; Region: IF-2; TIGR00487 525919002247 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525919002248 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 525919002249 G1 box; other site 525919002250 putative GEF interaction site [polypeptide binding]; other site 525919002251 GTP/Mg2+ binding site [chemical binding]; other site 525919002252 Switch I region; other site 525919002253 G2 box; other site 525919002254 G3 box; other site 525919002255 Switch II region; other site 525919002256 G4 box; other site 525919002257 G5 box; other site 525919002258 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 525919002259 Translation-initiation factor 2; Region: IF-2; pfam11987 525919002260 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 525919002261 Ribosome-binding factor A; Region: RBFA; cl00542 525919002262 DHH family; Region: DHH; pfam01368 525919002263 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525919002264 DHHA1 domain; Region: DHHA1; pfam02272 525919002265 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 525919002266 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 525919002267 RNA binding site [nucleotide binding]; other site 525919002268 active site 525919002269 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 525919002270 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 525919002271 active site 525919002272 Riboflavin kinase; Region: Flavokinase; cl03312 525919002273 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 525919002274 16S/18S rRNA binding site [nucleotide binding]; other site 525919002275 S13e-L30e interaction site [polypeptide binding]; other site 525919002276 25S rRNA binding site [nucleotide binding]; other site 525919002277 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 525919002278 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 525919002279 RNase E interface [polypeptide binding]; other site 525919002280 trimer interface [polypeptide binding]; other site 525919002281 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 525919002282 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 525919002283 RNase E interface [polypeptide binding]; other site 525919002284 trimer interface [polypeptide binding]; other site 525919002285 active site 525919002286 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 525919002287 putative nucleic acid binding region [nucleotide binding]; other site 525919002288 G-X-X-G motif; other site 525919002289 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525919002290 RNA binding site [nucleotide binding]; other site 525919002291 domain interface; other site 525919002292 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525919002293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002294 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 525919002295 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 525919002296 recombinase A; Provisional; Region: recA; PRK09354 525919002297 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 525919002298 hexamer interface [polypeptide binding]; other site 525919002299 Walker A motif; other site 525919002300 ATP binding site [chemical binding]; other site 525919002301 Walker B motif; other site 525919002302 DNA polymerase IV; Provisional; Region: PRK14133 525919002303 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525919002304 active site 525919002305 DNA binding site [nucleotide binding] 525919002306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525919002307 RNA binding surface [nucleotide binding]; other site 525919002308 Septum formation initiator; Region: DivIC; cl11433 525919002309 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525919002310 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 525919002311 Ligand Binding Site [chemical binding]; other site 525919002312 B3/4 domain; Region: B3_4; cl11458 525919002313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919002314 active site 525919002315 Type III pantothenate kinase; Region: Pan_kinase; cl09130 525919002316 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 525919002317 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525919002318 FMN binding site [chemical binding]; other site 525919002319 active site 525919002320 catalytic residues [active] 525919002321 substrate binding site [chemical binding]; other site 525919002322 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 525919002323 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525919002324 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 525919002325 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 525919002326 dimer interface [polypeptide binding]; other site 525919002327 putative anticodon binding site; other site 525919002328 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 525919002329 motif 1; other site 525919002330 active site 525919002331 motif 2; other site 525919002332 motif 3; other site 525919002333 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 525919002334 dimer interface [polypeptide binding]; other site 525919002335 putative tRNA-binding site [nucleotide binding]; other site 525919002336 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 525919002337 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 525919002338 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 525919002339 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 525919002340 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919002341 intersubunit interface [polypeptide binding]; other site 525919002342 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 525919002343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919002344 ABC-ATPase subunit interface; other site 525919002345 dimer interface [polypeptide binding]; other site 525919002346 putative PBP binding regions; other site 525919002347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919002348 ABC-ATPase subunit interface; other site 525919002349 dimer interface [polypeptide binding]; other site 525919002350 putative PBP binding regions; other site 525919002351 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 525919002352 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525919002353 Walker A/P-loop; other site 525919002354 ATP binding site [chemical binding]; other site 525919002355 Q-loop/lid; other site 525919002356 ABC transporter signature motif; other site 525919002357 Walker B; other site 525919002358 D-loop; other site 525919002359 H-loop/switch region; other site 525919002360 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 525919002361 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 525919002362 putative active site [active] 525919002363 putative metal binding site [ion binding]; other site 525919002364 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 525919002365 active site 525919002366 ABC-2 type transporter; Region: ABC2_membrane; cl11417 525919002367 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 525919002368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002369 Walker A/P-loop; other site 525919002370 ATP binding site [chemical binding]; other site 525919002371 Q-loop/lid; other site 525919002372 ABC transporter signature motif; other site 525919002373 Walker B; other site 525919002374 D-loop; other site 525919002375 H-loop/switch region; other site 525919002376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919002377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919002378 active site 525919002379 phosphorylation site [posttranslational modification] 525919002380 intermolecular recognition site; other site 525919002381 dimerization interface [polypeptide binding]; other site 525919002382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919002383 DNA binding site [nucleotide binding] 525919002384 sensor kinase CusS; Provisional; Region: PRK09835 525919002385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 525919002386 dimer interface [polypeptide binding]; other site 525919002387 phosphorylation site [posttranslational modification] 525919002388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 525919002389 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919002390 MatE; Region: MatE; cl10513 525919002391 MatE; Region: MatE; cl10513 525919002392 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 525919002393 putative nucleotide binding site [chemical binding]; other site 525919002394 uridine monophosphate binding site [chemical binding]; other site 525919002395 homohexameric interface [polypeptide binding]; other site 525919002396 ribosome recycling factor; Reviewed; Region: frr; PRK00083 525919002397 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 525919002398 hinge region; other site 525919002399 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 525919002400 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 525919002401 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 525919002402 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 525919002403 Acetokinase family; Region: Acetate_kinase; cl01029 525919002404 propionate/acetate kinase; Provisional; Region: PRK12379 525919002405 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 525919002406 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 525919002407 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 525919002408 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 525919002409 dimerization interface [polypeptide binding]; other site 525919002410 active site 525919002411 metal binding site [ion binding]; metal-binding site 525919002412 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 525919002413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919002414 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525919002415 FeS/SAM binding site; other site 525919002416 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 525919002417 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 525919002418 Walker A/P-loop; other site 525919002419 ATP binding site [chemical binding]; other site 525919002420 Q-loop/lid; other site 525919002421 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 525919002422 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 525919002423 Q-loop/lid; other site 525919002424 ABC transporter signature motif; other site 525919002425 Walker B; other site 525919002426 D-loop; other site 525919002427 H-loop/switch region; other site 525919002428 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525919002429 active site 525919002430 catalytic residues [active] 525919002431 metal binding site [ion binding]; metal-binding site 525919002432 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 525919002433 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 525919002434 putative active site [active] 525919002435 substrate binding site [chemical binding]; other site 525919002436 putative cosubstrate binding site; other site 525919002437 catalytic site [active] 525919002438 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 525919002439 substrate binding site [chemical binding]; other site 525919002440 16S rRNA methyltransferase B; Provisional; Region: PRK14902 525919002441 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 525919002442 putative RNA binding site [nucleotide binding]; other site 525919002443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919002444 S-adenosylmethionine binding site [chemical binding]; other site 525919002445 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 525919002446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919002447 FeS/SAM binding site; other site 525919002448 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 525919002449 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 525919002450 active site 525919002451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 525919002452 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525919002453 active site 525919002454 ATP binding site [chemical binding]; other site 525919002455 substrate binding site [chemical binding]; other site 525919002456 activation loop (A-loop); other site 525919002457 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525919002458 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525919002459 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 525919002460 GTPase RsgA; Reviewed; Region: PRK00098 525919002461 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 525919002462 RNA binding site [nucleotide binding]; other site 525919002463 homodimer interface [polypeptide binding]; other site 525919002464 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 525919002465 GTPase/Zn-binding domain interface [polypeptide binding]; other site 525919002466 GTP/Mg2+ binding site [chemical binding]; other site 525919002467 G4 box; other site 525919002468 G5 box; other site 525919002469 G1 box; other site 525919002470 Switch I region; other site 525919002471 G2 box; other site 525919002472 G3 box; other site 525919002473 Switch II region; other site 525919002474 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525919002475 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 525919002476 substrate binding site [chemical binding]; other site 525919002477 hexamer interface [polypeptide binding]; other site 525919002478 metal binding site [ion binding]; metal-binding site 525919002479 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 525919002480 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 525919002481 FAD binding domain; Region: FAD_binding_4; pfam01565 525919002482 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 525919002483 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 525919002484 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 525919002485 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 525919002486 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 525919002487 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 525919002488 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 525919002489 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 525919002490 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 525919002491 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 525919002492 generic binding surface I; other site 525919002493 generic binding surface II; other site 525919002494 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 525919002495 active site 525919002496 ADP/pyrophosphate binding site [chemical binding]; other site 525919002497 dimerization interface [polypeptide binding]; other site 525919002498 allosteric effector site; other site 525919002499 fructose-1,6-bisphosphate binding site; other site 525919002500 pyruvate kinase; Provisional; Region: PRK06354 525919002501 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 525919002502 domain interfaces; other site 525919002503 active site 525919002504 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 525919002505 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 525919002506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919002507 S-adenosylmethionine binding site [chemical binding]; other site 525919002508 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525919002509 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 525919002510 AAA ATPase domain; Region: AAA_15; pfam13175 525919002511 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 525919002512 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 525919002513 putative active site [active] 525919002514 putative metal-binding site [ion binding]; other site 525919002515 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525919002516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002517 Family description; Region: UvrD_C_2; cl15862 525919002518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525919002519 Helix-turn-helix domains; Region: HTH; cl00088 525919002520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919002521 dimer interface [polypeptide binding]; other site 525919002522 conserved gate region; other site 525919002523 putative PBP binding loops; other site 525919002524 ABC-ATPase subunit interface; other site 525919002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525919002526 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919002527 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 525919002528 Walker A/P-loop; other site 525919002529 ATP binding site [chemical binding]; other site 525919002530 Q-loop/lid; other site 525919002531 ABC transporter signature motif; other site 525919002532 Walker B; other site 525919002533 D-loop; other site 525919002534 H-loop/switch region; other site 525919002535 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 525919002536 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919002537 Walker A/P-loop; other site 525919002538 ATP binding site [chemical binding]; other site 525919002539 Q-loop/lid; other site 525919002540 ABC transporter signature motif; other site 525919002541 Walker B; other site 525919002542 D-loop; other site 525919002543 H-loop/switch region; other site 525919002544 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 525919002545 substrate binding site [chemical binding]; other site 525919002546 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 525919002547 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919002548 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919002549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002550 Walker A/P-loop; other site 525919002551 ATP binding site [chemical binding]; other site 525919002552 Q-loop/lid; other site 525919002553 ABC transporter signature motif; other site 525919002554 Walker B; other site 525919002555 D-loop; other site 525919002556 H-loop/switch region; other site 525919002557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919002558 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919002559 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 525919002560 Walker A/P-loop; other site 525919002561 ATP binding site [chemical binding]; other site 525919002562 Q-loop/lid; other site 525919002563 ABC transporter signature motif; other site 525919002564 Walker B; other site 525919002565 D-loop; other site 525919002566 H-loop/switch region; other site 525919002567 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 525919002568 catalytic residues [active] 525919002569 catalytic nucleophile [active] 525919002570 Recombinase; Region: Recombinase; pfam07508 525919002571 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 525919002572 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 525919002573 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 525919002574 Cadmium resistance transporter; Region: Cad; cl04177 525919002575 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919002576 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525919002577 intersubunit interface [polypeptide binding]; other site 525919002578 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525919002579 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 525919002580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919002581 ABC-ATPase subunit interface; other site 525919002582 dimer interface [polypeptide binding]; other site 525919002583 putative PBP binding regions; other site 525919002584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919002585 ABC-ATPase subunit interface; other site 525919002586 dimer interface [polypeptide binding]; other site 525919002587 putative PBP binding regions; other site 525919002588 Helix-turn-helix domains; Region: HTH; cl00088 525919002589 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 525919002590 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 525919002591 Helix-turn-helix domain; Region: HTH_18; pfam12833 525919002592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525919002593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919002594 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919002595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002596 Walker A/P-loop; other site 525919002597 ATP binding site [chemical binding]; other site 525919002598 Q-loop/lid; other site 525919002599 ABC transporter signature motif; other site 525919002600 Walker B; other site 525919002601 D-loop; other site 525919002602 H-loop/switch region; other site 525919002603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919002604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002605 Walker A/P-loop; other site 525919002606 ATP binding site [chemical binding]; other site 525919002607 Q-loop/lid; other site 525919002608 ABC transporter signature motif; other site 525919002609 Walker B; other site 525919002610 D-loop; other site 525919002611 H-loop/switch region; other site 525919002612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919002613 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 525919002614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525919002615 Phage Terminase; Region: Terminase_1; pfam03354 525919002616 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 525919002617 dimer interface [polypeptide binding]; other site 525919002618 catalytic residues [active] 525919002619 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 525919002620 UreF; Region: UreF; pfam01730 525919002621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002622 UreD urease accessory protein; Region: UreD; cl00530 525919002623 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 525919002624 alpha-gamma subunit interface [polypeptide binding]; other site 525919002625 beta-gamma subunit interface [polypeptide binding]; other site 525919002626 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 525919002627 gamma-beta subunit interface [polypeptide binding]; other site 525919002628 alpha-beta subunit interface [polypeptide binding]; other site 525919002629 urease subunit alpha; Reviewed; Region: ureC; PRK13207 525919002630 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 525919002631 subunit interactions [polypeptide binding]; other site 525919002632 active site 525919002633 flap region; other site 525919002634 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525919002635 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525919002636 chaperone protein DnaJ; Provisional; Region: PRK14278 525919002637 HIRAN domain; Region: HIRAN; cl07418 525919002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919002639 non-specific DNA binding site [nucleotide binding]; other site 525919002640 salt bridge; other site 525919002641 sequence-specific DNA binding site [nucleotide binding]; other site 525919002642 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 525919002643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525919002644 Coenzyme A binding pocket [chemical binding]; other site 525919002645 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919002646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919002647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919002648 active site 525919002649 phosphorylation site [posttranslational modification] 525919002650 intermolecular recognition site; other site 525919002651 dimerization interface [polypeptide binding]; other site 525919002652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919002653 DNA binding site [nucleotide binding] 525919002654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 525919002655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919002656 dimer interface [polypeptide binding]; other site 525919002657 phosphorylation site [posttranslational modification] 525919002658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919002659 ATP binding site [chemical binding]; other site 525919002660 Mg2+ binding site [ion binding]; other site 525919002661 G-X-G motif; other site 525919002662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919002663 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919002664 Walker A/P-loop; other site 525919002665 ATP binding site [chemical binding]; other site 525919002666 Q-loop/lid; other site 525919002667 ABC transporter signature motif; other site 525919002668 Walker B; other site 525919002669 D-loop; other site 525919002670 H-loop/switch region; other site 525919002671 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525919002672 FtsX-like permease family; Region: FtsX; cl15850 525919002673 FtsX-like permease family; Region: FtsX; cl15850 525919002674 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525919002675 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525919002676 Active site serine [active] 525919002677 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 525919002678 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 525919002679 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 525919002680 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 525919002681 RNA binding site [nucleotide binding]; other site 525919002682 prolyl-tRNA synthetase; Provisional; Region: PRK09194 525919002683 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 525919002684 dimer interface [polypeptide binding]; other site 525919002685 motif 1; other site 525919002686 active site 525919002687 motif 2; other site 525919002688 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 525919002689 putative deacylase active site [active] 525919002690 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 525919002691 active site 525919002692 motif 3; other site 525919002693 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 525919002694 anticodon binding site; other site 525919002695 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 525919002696 hypothetical protein; Provisional; Region: PRK08185 525919002697 intersubunit interface [polypeptide binding]; other site 525919002698 active site 525919002699 zinc binding site [ion binding]; other site 525919002700 Na+ binding site [ion binding]; other site 525919002701 transcription termination factor Rho; Provisional; Region: PRK12608 525919002702 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525919002703 RNA binding site [nucleotide binding]; other site 525919002704 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002705 Walker A motif; other site 525919002706 ATP binding site [chemical binding]; other site 525919002707 Walker B motif; other site 525919002708 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 525919002709 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 525919002710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919002711 S-adenosylmethionine binding site [chemical binding]; other site 525919002712 peptide chain release factor 1; Validated; Region: prfA; PRK00591 525919002713 RF-1 domain; Region: RF-1; cl02875 525919002714 RF-1 domain; Region: RF-1; cl02875 525919002715 Cation efflux family; Region: Cation_efflux; cl00316 525919002716 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 525919002717 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 525919002718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919002719 active site 525919002720 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525919002721 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525919002722 hinge; other site 525919002723 active site 525919002724 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 525919002725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002726 Family description; Region: UvrD_C_2; cl15862 525919002727 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 525919002728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919002729 active site 525919002730 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 525919002731 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 525919002732 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525919002733 minor groove reading motif; other site 525919002734 helix-hairpin-helix signature motif; other site 525919002735 substrate binding pocket [chemical binding]; other site 525919002736 active site 525919002737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919002738 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919002739 active site 525919002740 motif I; other site 525919002741 motif II; other site 525919002742 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919002743 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 525919002744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525919002745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919002746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525919002747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919002748 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525919002749 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 525919002750 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 525919002751 Phosphoglycerate kinase; Region: PGK; pfam00162 525919002752 substrate binding site [chemical binding]; other site 525919002753 hinge regions; other site 525919002754 ADP binding site [chemical binding]; other site 525919002755 catalytic site [active] 525919002756 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 525919002757 substrate binding site [chemical binding]; other site 525919002758 dimer interface [polypeptide binding]; other site 525919002759 catalytic triad [active] 525919002760 enolase; Provisional; Region: eno; PRK00077 525919002761 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 525919002762 dimer interface [polypeptide binding]; other site 525919002763 metal binding site [ion binding]; metal-binding site 525919002764 substrate binding pocket [chemical binding]; other site 525919002765 ribonuclease R; Region: RNase_R; TIGR02063 525919002766 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525919002767 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525919002768 RNB domain; Region: RNB; pfam00773 525919002769 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 525919002770 RNA binding site [nucleotide binding]; other site 525919002771 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 525919002772 SmpB-tmRNA interface; other site 525919002773 Thymidylate synthase complementing protein; Region: Thy1; cl03630 525919002774 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919002775 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919002776 Walker A/P-loop; other site 525919002777 ATP binding site [chemical binding]; other site 525919002778 Q-loop/lid; other site 525919002779 ABC transporter signature motif; other site 525919002780 Walker B; other site 525919002781 D-loop; other site 525919002782 H-loop/switch region; other site 525919002783 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 525919002784 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 525919002785 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 525919002786 FtsX-like permease family; Region: FtsX; cl15850 525919002787 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525919002788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525919002789 FtsX-like permease family; Region: FtsX; cl15850 525919002790 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525919002791 catalytic core [active] 525919002792 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 525919002793 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525919002794 active site 525919002795 metal binding site [ion binding]; metal-binding site 525919002796 DNA binding site [nucleotide binding] 525919002797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002798 AAA domain; Region: AAA_23; pfam13476 525919002799 Walker A/P-loop; other site 525919002800 ATP binding site [chemical binding]; other site 525919002801 AAA domain; Region: AAA_27; pfam13514 525919002802 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525919002803 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525919002804 active site 525919002805 metal binding site [ion binding]; metal-binding site 525919002806 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 525919002807 putative active site [active] 525919002808 putative metal binding residues [ion binding]; other site 525919002809 signature motif; other site 525919002810 putative triphosphate binding site [ion binding]; other site 525919002811 dimer interface [polypeptide binding]; other site 525919002812 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 525919002813 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525919002814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919002815 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 525919002816 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 525919002817 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 525919002818 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525919002819 dihydroorotase; Validated; Region: pyrC; PRK09357 525919002820 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 525919002821 active site 525919002822 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 525919002823 active site 525919002824 dimer interface [polypeptide binding]; other site 525919002825 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 525919002826 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 525919002827 FAD binding pocket [chemical binding]; other site 525919002828 FAD binding motif [chemical binding]; other site 525919002829 phosphate binding motif [ion binding]; other site 525919002830 beta-alpha-beta structure motif; other site 525919002831 NAD binding pocket [chemical binding]; other site 525919002832 Iron coordination center [ion binding]; other site 525919002833 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 525919002834 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525919002835 heterodimer interface [polypeptide binding]; other site 525919002836 active site 525919002837 FMN binding site [chemical binding]; other site 525919002838 homodimer interface [polypeptide binding]; other site 525919002839 substrate binding site [chemical binding]; other site 525919002840 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 525919002841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919002842 active site 525919002843 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 525919002844 glycogen branching enzyme; Provisional; Region: PRK12313 525919002845 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 525919002846 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 525919002847 active site 525919002848 catalytic site [active] 525919002849 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 525919002850 FOG: CBS domain [General function prediction only]; Region: COG0517 525919002851 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 525919002852 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 525919002853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919002854 Walker A motif; other site 525919002855 ATP binding site [chemical binding]; other site 525919002856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919002857 Walker B motif; other site 525919002858 arginine finger; other site 525919002859 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 525919002860 recombination protein RecR; Reviewed; Region: recR; PRK00076 525919002861 RecR protein; Region: RecR; pfam02132 525919002862 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 525919002863 putative active site [active] 525919002864 putative metal-binding site [ion binding]; other site 525919002865 tetramer interface [polypeptide binding]; other site 525919002866 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 525919002867 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 525919002868 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 525919002869 substrate binding [chemical binding]; other site 525919002870 active site 525919002871 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 525919002872 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525919002873 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 525919002874 Int/Topo IB signature motif; other site 525919002875 Predicted transcriptional regulator [Transcription]; Region: COG2932 525919002876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919002877 non-specific DNA binding site [nucleotide binding]; other site 525919002878 salt bridge; other site 525919002879 sequence-specific DNA binding site [nucleotide binding]; other site 525919002880 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525919002881 Catalytic site [active] 525919002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919002883 sequence-specific DNA binding site [nucleotide binding]; other site 525919002884 salt bridge; other site 525919002885 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 525919002886 ERF superfamily; Region: ERF; pfam04404 525919002887 hypothetical protein; Validated; Region: PRK08116 525919002888 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525919002889 dimer interface [polypeptide binding]; other site 525919002890 ssDNA binding site [nucleotide binding]; other site 525919002891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525919002892 Endodeoxyribonuclease RusA; Region: RusA; cl01885 525919002893 beta-phosphoglucomutase; Region: bPGM; TIGR01990 525919002894 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 525919002895 ParB-like nuclease domain; Region: ParBc; cl02129 525919002896 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 525919002897 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525919002898 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 525919002899 Phage terminase large subunit; Region: Terminase_3; cl12054 525919002900 Terminase-like family; Region: Terminase_6; pfam03237 525919002901 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 525919002902 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 525919002903 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 525919002904 TMPIT-like protein; Region: TMPIT; pfam07851 525919002905 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 525919002906 Phage capsid family; Region: Phage_capsid; pfam05065 525919002907 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 525919002908 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 525919002909 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 525919002910 Phage-related protein [Function unknown]; Region: COG5412 525919002911 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 525919002912 Baseplate J-like protein; Region: Baseplate_J; cl01294 525919002913 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 525919002914 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 525919002915 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 525919002916 NlpC/P60 family; Region: NLPC_P60; cl11438 525919002917 Bacterial SH3 domain; Region: SH3_3; cl02551 525919002918 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 525919002919 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 525919002920 ligand binding site; other site 525919002921 oligomer interface; other site 525919002922 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 525919002923 dimer interface [polypeptide binding]; other site 525919002924 N-terminal domain interface [polypeptide binding]; other site 525919002925 sulfate 1 binding site; other site 525919002926 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 525919002927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525919002928 active site 525919002929 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 525919002930 dimer interface [polypeptide binding]; other site 525919002931 N-terminal domain interface [polypeptide binding]; other site 525919002932 sulfate 1 binding site; other site 525919002933 glycogen synthase; Provisional; Region: glgA; PRK00654 525919002934 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 525919002935 ADP-binding pocket [chemical binding]; other site 525919002936 homodimer interface [polypeptide binding]; other site 525919002937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525919002938 glycogen phosphorylase; Provisional; Region: PRK14986 525919002939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525919002940 pullulanase, type I; Region: pulA_typeI; TIGR02104 525919002941 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 525919002942 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 525919002943 Ca binding site [ion binding]; other site 525919002944 active site 525919002945 catalytic site [active] 525919002946 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 525919002947 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 525919002948 active site 525919002949 substrate binding site [chemical binding]; other site 525919002950 metal binding site [ion binding]; metal-binding site 525919002951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 525919002952 phosphopeptide binding site; other site 525919002953 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 525919002954 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525919002955 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525919002956 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525919002957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919002958 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 525919002959 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525919002960 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 525919002961 active site 525919002962 YtxH-like protein; Region: YtxH; cl02079 525919002963 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525919002964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525919002965 DNA binding site [nucleotide binding] 525919002966 domain linker motif; other site 525919002967 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525919002968 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 525919002969 dimerization domain swap beta strand [polypeptide binding]; other site 525919002970 regulatory protein interface [polypeptide binding]; other site 525919002971 active site 525919002972 regulatory phosphorylation site [posttranslational modification]; other site 525919002973 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 525919002974 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 525919002975 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 525919002976 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 525919002977 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525919002978 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525919002979 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525919002980 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 525919002981 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 525919002982 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 525919002983 PPIC-type PPIASE domain; Region: Rotamase; cl08278 525919002984 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525919002985 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525919002986 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525919002987 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 525919002988 active site 525919002989 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 525919002990 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919002991 Ycf27; Reviewed; Region: orf27; CHL00148 525919002992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919002993 active site 525919002994 phosphorylation site [posttranslational modification] 525919002995 intermolecular recognition site; other site 525919002996 dimerization interface [polypeptide binding]; other site 525919002997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919002998 DNA binding site [nucleotide binding] 525919002999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525919003000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525919003001 dimerization interface [polypeptide binding]; other site 525919003002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919003003 dimer interface [polypeptide binding]; other site 525919003004 phosphorylation site [posttranslational modification] 525919003005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919003006 ATP binding site [chemical binding]; other site 525919003007 Mg2+ binding site [ion binding]; other site 525919003008 G-X-G motif; other site 525919003009 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 525919003010 active site 525919003011 dimerization interface [polypeptide binding]; other site 525919003012 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 525919003013 active site 525919003014 metal binding site [ion binding]; metal-binding site 525919003015 homotetramer interface [polypeptide binding]; other site 525919003016 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 525919003017 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919003018 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 525919003019 active site 525919003020 putative DNA-binding cleft [nucleotide binding]; other site 525919003021 dimer interface [polypeptide binding]; other site 525919003022 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 525919003023 RuvA N terminal domain; Region: RuvA_N; pfam01330 525919003024 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 525919003025 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 525919003026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919003027 Walker A motif; other site 525919003028 ATP binding site [chemical binding]; other site 525919003029 Walker B motif; other site 525919003030 arginine finger; other site 525919003031 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 525919003032 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 525919003033 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 525919003034 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 525919003035 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 525919003036 Preprotein translocase subunit; Region: YajC; cl00806 525919003037 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 525919003038 DHH family; Region: DHH; pfam01368 525919003039 DHHA1 domain; Region: DHHA1; pfam02272 525919003040 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525919003041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 525919003042 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525919003043 synthetase active site [active] 525919003044 NTP binding site [chemical binding]; other site 525919003045 metal binding site [ion binding]; metal-binding site 525919003046 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 525919003047 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 525919003048 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 525919003049 putative active site [active] 525919003050 dimerization interface [polypeptide binding]; other site 525919003051 putative tRNAtyr binding site [nucleotide binding]; other site 525919003052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919003053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 525919003054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 525919003055 dimer interface [polypeptide binding]; other site 525919003056 anticodon binding site; other site 525919003057 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 525919003058 homodimer interface [polypeptide binding]; other site 525919003059 motif 1; other site 525919003060 active site 525919003061 motif 2; other site 525919003062 GAD domain; Region: GAD; pfam02938 525919003063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 525919003064 active site 525919003065 motif 3; other site 525919003066 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 525919003067 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 525919003068 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 525919003069 dimer interface [polypeptide binding]; other site 525919003070 glycine-pyridoxal phosphate binding site [chemical binding]; other site 525919003071 active site 525919003072 folate binding site [chemical binding]; other site 525919003073 GTP-binding protein Der; Reviewed; Region: PRK00093 525919003074 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 525919003075 G1 box; other site 525919003076 GTP/Mg2+ binding site [chemical binding]; other site 525919003077 Switch I region; other site 525919003078 G2 box; other site 525919003079 Switch II region; other site 525919003080 G3 box; other site 525919003081 G4 box; other site 525919003082 G5 box; other site 525919003083 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 525919003084 G1 box; other site 525919003085 GTP/Mg2+ binding site [chemical binding]; other site 525919003086 Switch I region; other site 525919003087 G2 box; other site 525919003088 G3 box; other site 525919003089 Switch II region; other site 525919003090 G4 box; other site 525919003091 G5 box; other site 525919003092 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 525919003093 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 525919003094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003095 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 525919003096 Protein of unknown function (DUF552); Region: DUF552; cl00775 525919003097 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 525919003098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525919003099 RNA binding surface [nucleotide binding]; other site 525919003100 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 525919003101 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 525919003102 ligand binding site [chemical binding]; other site 525919003103 active site 525919003104 UGI interface [polypeptide binding]; other site 525919003105 catalytic site [active] 525919003106 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525919003107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919003108 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 525919003109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919003110 catalytic residue [active] 525919003111 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 525919003112 THUMP domain; Region: THUMP; cl12076 525919003113 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 525919003114 Ligand Binding Site [chemical binding]; other site 525919003115 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 525919003116 Protein of unknown function (DUF464); Region: DUF464; cl01080 525919003117 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 525919003118 GTPase CgtA; Reviewed; Region: obgE; PRK12297 525919003119 GTP1/OBG; Region: GTP1_OBG; pfam01018 525919003120 Obg GTPase; Region: Obg; cd01898 525919003121 G1 box; other site 525919003122 GTP/Mg2+ binding site [chemical binding]; other site 525919003123 Switch I region; other site 525919003124 G2 box; other site 525919003125 G3 box; other site 525919003126 Switch II region; other site 525919003127 G4 box; other site 525919003128 G5 box; other site 525919003129 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 525919003130 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 525919003131 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 525919003132 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 525919003133 active site 525919003134 (T/H)XGH motif; other site 525919003135 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 525919003136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525919003137 Zn2+ binding site [ion binding]; other site 525919003138 Mg2+ binding site [ion binding]; other site 525919003139 Oligomerisation domain; Region: Oligomerisation; cl00519 525919003140 SLBB domain; Region: SLBB; pfam10531 525919003141 comEA protein; Region: comE; TIGR01259 525919003142 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 525919003143 Helix-turn-helix domains; Region: HTH; cl00088 525919003144 Rrf2 family protein; Region: rrf2_super; TIGR00738 525919003145 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 525919003146 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 525919003147 motif 1; other site 525919003148 active site 525919003149 motif 2; other site 525919003150 motif 3; other site 525919003151 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 525919003152 DHHA1 domain; Region: DHHA1; pfam02272 525919003153 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 525919003154 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 525919003155 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525919003156 metal binding site 2 [ion binding]; metal-binding site 525919003157 putative DNA binding helix; other site 525919003158 metal binding site 1 [ion binding]; metal-binding site 525919003159 dimer interface [polypeptide binding]; other site 525919003160 structural Zn2+ binding site [ion binding]; other site 525919003161 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525919003162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919003163 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525919003164 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 525919003165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919003166 S-adenosylmethionine binding site [chemical binding]; other site 525919003167 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525919003168 Peptidase family U32; Region: Peptidase_U32; cl03113 525919003169 peptidase T; Region: peptidase-T; TIGR01882 525919003170 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 525919003171 metal binding site [ion binding]; metal-binding site 525919003172 dimer interface [polypeptide binding]; other site 525919003173 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525919003174 trimer interface [polypeptide binding]; other site 525919003175 active site 525919003176 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 525919003177 MutS domain I; Region: MutS_I; pfam01624 525919003178 MutS domain II; Region: MutS_II; pfam05188 525919003179 MutS family domain IV; Region: MutS_IV; pfam05190 525919003180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003181 Walker A/P-loop; other site 525919003182 ATP binding site [chemical binding]; other site 525919003183 Q-loop/lid; other site 525919003184 ABC transporter signature motif; other site 525919003185 Walker B; other site 525919003186 D-loop; other site 525919003187 H-loop/switch region; other site 525919003188 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 525919003189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919003190 ATP binding site [chemical binding]; other site 525919003191 Mg2+ binding site [ion binding]; other site 525919003192 G-X-G motif; other site 525919003193 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 525919003194 ATP binding site [chemical binding]; other site 525919003195 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 525919003196 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 525919003197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003198 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 525919003199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919003200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919003201 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919003202 catalytic residue [active] 525919003203 catalytic residue [active] 525919003204 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 525919003205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525919003206 DNA binding site [nucleotide binding] 525919003207 Int/Topo IB signature motif; other site 525919003208 active site 525919003209 phosphodiesterase; Provisional; Region: PRK12704 525919003210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525919003211 Zn2+ binding site [ion binding]; other site 525919003212 Mg2+ binding site [ion binding]; other site 525919003213 serine O-acetyltransferase; Region: cysE; TIGR01172 525919003214 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 525919003215 trimer interface [polypeptide binding]; other site 525919003216 active site 525919003217 substrate binding site [chemical binding]; other site 525919003218 CoA binding site [chemical binding]; other site 525919003219 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525919003220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525919003221 dimer interface [polypeptide binding]; other site 525919003222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919003223 catalytic residue [active] 525919003224 elongation factor Ts; Reviewed; Region: tsf; PRK12332 525919003225 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 525919003226 Elongation factor TS; Region: EF_TS; pfam00889 525919003227 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 525919003228 rRNA interaction site [nucleotide binding]; other site 525919003229 S8 interaction site; other site 525919003230 putative laminin-1 binding site; other site 525919003231 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 525919003232 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 525919003233 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525919003234 P loop; other site 525919003235 GTP binding site [chemical binding]; other site 525919003236 primosome assembly protein PriA; Validated; Region: PRK05580 525919003237 primosome assembly protein PriA; Validated; Region: PRK05580 525919003238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919003239 ATP binding site [chemical binding]; other site 525919003240 putative Mg++ binding site [ion binding]; other site 525919003241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003242 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 525919003243 Flavoprotein; Region: Flavoprotein; cl08021 525919003244 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 525919003245 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 525919003246 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 525919003247 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 525919003248 catalytic site [active] 525919003249 G-X2-G-X-G-K; other site 525919003250 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 525919003251 Domain of unknown function (DUF814); Region: DUF814; pfam05670 525919003252 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525919003253 IHF dimer interface [polypeptide binding]; other site 525919003254 IHF - DNA interface [nucleotide binding]; other site 525919003255 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 525919003256 PPIC-type PPIASE domain; Region: Rotamase; cl08278 525919003257 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 525919003258 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 525919003259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919003260 ATP binding site [chemical binding]; other site 525919003261 putative Mg++ binding site [ion binding]; other site 525919003262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919003263 nucleotide binding region [chemical binding]; other site 525919003264 ATP-binding site [chemical binding]; other site 525919003265 TRCF domain; Region: TRCF; cl04088 525919003266 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 525919003267 putative active site [active] 525919003268 catalytic residue [active] 525919003269 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 525919003270 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525919003271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919003272 active site 525919003273 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 525919003274 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 525919003275 Substrate binding site; other site 525919003276 Mg++ binding site; other site 525919003277 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 525919003278 active site 525919003279 substrate binding site [chemical binding]; other site 525919003280 CoA binding site [chemical binding]; other site 525919003281 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 525919003282 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 525919003283 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 525919003284 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525919003285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919003286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525919003287 PemK-like protein; Region: PemK; cl00995 525919003288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 525919003289 alanine racemase; Reviewed; Region: alr; PRK00053 525919003290 active site 525919003291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525919003292 dimer interface [polypeptide binding]; other site 525919003293 substrate binding site [chemical binding]; other site 525919003294 catalytic residues [active] 525919003295 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 525919003296 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 525919003297 putative substrate binding site [chemical binding]; other site 525919003298 putative ATP binding site [chemical binding]; other site 525919003299 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 525919003300 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 525919003301 active site 525919003302 putative substrate binding pocket [chemical binding]; other site 525919003303 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 525919003304 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 525919003305 GatB domain; Region: GatB_Yqey; cl11497 525919003306 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525919003307 Amidase; Region: Amidase; cl11426 525919003308 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 525919003309 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 525919003310 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 525919003311 nucleotide binding pocket [chemical binding]; other site 525919003312 K-X-D-G motif; other site 525919003313 catalytic site [active] 525919003314 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 525919003315 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525919003316 Dimer interface [polypeptide binding]; other site 525919003317 BRCT sequence motif; other site 525919003318 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 525919003319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003320 Family description; Region: UvrD_C_2; cl15862 525919003321 Helix-turn-helix domains; Region: HTH; cl00088 525919003322 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 525919003323 catalytic triad [active] 525919003324 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919003325 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 525919003326 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 525919003327 Acylphosphatase; Region: Acylphosphatase; cl00551 525919003328 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525919003329 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525919003330 metal-binding site [ion binding] 525919003331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525919003332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919003333 motif II; other site 525919003334 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525919003335 metal-binding site [ion binding] 525919003336 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 525919003337 putative homotetramer interface [polypeptide binding]; other site 525919003338 putative homodimer interface [polypeptide binding]; other site 525919003339 putative allosteric switch controlling residues; other site 525919003340 putative metal binding site [ion binding]; other site 525919003341 putative homodimer-homodimer interface [polypeptide binding]; other site 525919003342 Asp23 family; Region: Asp23; cl00574 525919003343 QueT transporter; Region: QueT; cl01932 525919003344 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 525919003345 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 525919003346 putative active site [active] 525919003347 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 525919003348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919003349 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525919003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919003351 S-adenosylmethionine binding site [chemical binding]; other site 525919003352 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 525919003353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003354 DEAD_2; Region: DEAD_2; pfam06733 525919003355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003356 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 525919003357 dimer interface [polypeptide binding]; other site 525919003358 FMN binding site [chemical binding]; other site 525919003359 NADPH bind site [chemical binding]; other site 525919003360 Repair protein; Region: Repair_PSII; cl01535 525919003361 LemA family; Region: LemA; cl00742 525919003362 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 525919003363 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 525919003364 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 525919003365 ATP cone domain; Region: ATP-cone; pfam03477 525919003366 Class III ribonucleotide reductase; Region: RNR_III; cd01675 525919003367 effector binding site; other site 525919003368 active site 525919003369 Zn binding site [ion binding]; other site 525919003370 glycine loop; other site 525919003371 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 525919003372 Clp amino terminal domain; Region: Clp_N; pfam02861 525919003373 Clp amino terminal domain; Region: Clp_N; pfam02861 525919003374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919003375 Walker A motif; other site 525919003376 ATP binding site [chemical binding]; other site 525919003377 Walker B motif; other site 525919003378 arginine finger; other site 525919003379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919003380 Walker A motif; other site 525919003381 ATP binding site [chemical binding]; other site 525919003382 Walker B motif; other site 525919003383 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 525919003384 chaperone protein DnaJ; Provisional; Region: PRK14299 525919003385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525919003386 HSP70 interaction site [polypeptide binding]; other site 525919003387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525919003388 substrate binding site [polypeptide binding]; other site 525919003389 dimer interface [polypeptide binding]; other site 525919003390 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 525919003391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919003392 active site 525919003393 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 525919003394 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 525919003395 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525919003396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919003397 catalytic residue [active] 525919003398 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 525919003399 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 525919003400 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 525919003401 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525919003402 ATP synthase subunit D; Region: ATP-synt_D; cl00613 525919003403 V-type ATP synthase subunit B; Provisional; Region: PRK04196 525919003404 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 525919003405 Walker A motif homologous position; other site 525919003406 Walker B motif; other site 525919003407 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525919003408 V-type ATP synthase subunit A; Provisional; Region: PRK04192 525919003409 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 525919003410 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 525919003411 Walker A motif/ATP binding site; other site 525919003412 Walker B motif; other site 525919003413 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525919003414 Plant ATP synthase F0; Region: YMF19; cl07975 525919003415 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 525919003416 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 525919003417 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525919003418 potential frameshift: common BLAST hit: gi|28211926|ref|NP_782870.1| V-type sodium ATP synthase subunit I 525919003419 V-type ATP synthase subunit I; Validated; Region: PRK05771 525919003420 V-type ATP synthase subunit I; Validated; Region: PRK05771 525919003421 V-type ATP synthase subunit I; Validated; Region: PRK05771 525919003422 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 525919003423 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 525919003424 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525919003425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919003426 FeS/SAM binding site; other site 525919003427 TRAM domain; Region: TRAM; cl01282 525919003428 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 525919003429 LytB protein; Region: LYTB; cl00507 525919003430 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525919003431 RNA binding site [nucleotide binding]; other site 525919003432 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525919003433 RNA binding site [nucleotide binding]; other site 525919003434 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 525919003435 RNA binding site [nucleotide binding]; other site 525919003436 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 525919003437 RNA binding site [nucleotide binding]; other site 525919003438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525919003439 putative acyl-acceptor binding pocket; other site 525919003440 cytidylate kinase; Provisional; Region: cmk; PRK00023 525919003441 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 525919003442 CMP-binding site; other site 525919003443 The sites determining sugar specificity; other site 525919003444 flavoprotein, HI0933 family; Region: TIGR00275 525919003445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003446 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525919003447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525919003448 RNA binding surface [nucleotide binding]; other site 525919003449 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 525919003450 active site 525919003451 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 525919003452 ScpA/B protein; Region: ScpA_ScpB; cl00598 525919003453 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 525919003454 dimer interface [polypeptide binding]; other site 525919003455 ADP-ribose binding site [chemical binding]; other site 525919003456 active site 525919003457 nudix motif; other site 525919003458 metal binding site [ion binding]; metal-binding site 525919003459 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 525919003460 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 525919003461 Walker A/P-loop; other site 525919003462 ATP binding site [chemical binding]; other site 525919003463 Q-loop/lid; other site 525919003464 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 525919003465 Q-loop/lid; other site 525919003466 ABC transporter signature motif; other site 525919003467 Walker B; other site 525919003468 D-loop; other site 525919003469 H-loop/switch region; other site 525919003470 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 525919003471 arginine repressor; Provisional; Region: argR; PRK00441 525919003472 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 525919003473 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525919003474 substrate binding pocket [chemical binding]; other site 525919003475 chain length determination region; other site 525919003476 substrate-Mg2+ binding site; other site 525919003477 catalytic residues [active] 525919003478 aspartate-rich region 1; other site 525919003479 active site lid residues [active] 525919003480 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 525919003481 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 525919003482 generic binding surface II; other site 525919003483 generic binding surface I; other site 525919003484 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 525919003485 putative RNA binding site [nucleotide binding]; other site 525919003486 Asp23 family; Region: Asp23; cl00574 525919003487 elongation factor P; Validated; Region: PRK00529 525919003488 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 525919003489 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 525919003490 RNA binding site [nucleotide binding]; other site 525919003491 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 525919003492 RNA binding site [nucleotide binding]; other site 525919003493 hypothetical protein; Provisional; Region: PRK13670 525919003494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525919003495 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 525919003496 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 525919003497 active site 525919003498 (T/H)XGH motif; other site 525919003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919003500 S-adenosylmethionine binding site [chemical binding]; other site 525919003501 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 525919003502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919003503 ATP binding site [chemical binding]; other site 525919003504 putative Mg++ binding site [ion binding]; other site 525919003505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919003506 nucleotide binding region [chemical binding]; other site 525919003507 ATP-binding site [chemical binding]; other site 525919003508 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 525919003509 DAK2 domain; Region: Dak2; cl03685 525919003510 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 525919003511 Asp23 family; Region: Asp23; cl00574 525919003512 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 525919003513 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525919003514 dimer interface [polypeptide binding]; other site 525919003515 PYR/PP interface [polypeptide binding]; other site 525919003516 TPP binding site [chemical binding]; other site 525919003517 substrate binding site [chemical binding]; other site 525919003518 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 525919003519 Domain of unknown function; Region: EKR; cl11037 525919003520 4Fe-4S binding domain; Region: Fer4; cl02805 525919003521 4Fe-4S binding domain; Region: Fer4; cl02805 525919003522 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 525919003523 TPP-binding site [chemical binding]; other site 525919003524 dimer interface [polypeptide binding]; other site 525919003525 HPr kinase/phosphorylase; Provisional; Region: PRK05428 525919003526 DRTGG domain; Region: DRTGG; cl12147 525919003527 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 525919003528 Hpr binding site; other site 525919003529 active site 525919003530 homohexamer subunit interaction site [polypeptide binding]; other site 525919003531 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 525919003532 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 525919003533 GIY-YIG motif/motif A; other site 525919003534 active site 525919003535 catalytic site [active] 525919003536 putative DNA binding site [nucleotide binding]; other site 525919003537 metal binding site [ion binding]; metal-binding site 525919003538 UvrB/uvrC motif; Region: UVR; pfam02151 525919003539 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 525919003540 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525919003541 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525919003542 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525919003543 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 525919003544 active site 525919003545 GTP-binding protein YchF; Reviewed; Region: PRK09601 525919003546 YchF GTPase; Region: YchF; cd01900 525919003547 G1 box; other site 525919003548 GTP/Mg2+ binding site [chemical binding]; other site 525919003549 Switch I region; other site 525919003550 G2 box; other site 525919003551 Switch II region; other site 525919003552 G3 box; other site 525919003553 G4 box; other site 525919003554 G5 box; other site 525919003555 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 525919003556 thymidine kinase; Provisional; Region: PRK04296 525919003557 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525919003558 active site 525919003559 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525919003560 FMN binding site [chemical binding]; other site 525919003561 dimer interface [polypeptide binding]; other site 525919003562 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525919003563 dimer interface [polypeptide binding]; other site 525919003564 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525919003565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003566 Family description; Region: UvrD_C_2; cl15862 525919003567 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 525919003568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919003569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525919003570 intracellular protease, PfpI family; Region: PfpI; TIGR01382 525919003571 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 525919003572 proposed catalytic triad [active] 525919003573 conserved cys residue [active] 525919003574 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 525919003575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919003576 S-adenosylmethionine binding site [chemical binding]; other site 525919003577 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 525919003578 GAF domain; Region: GAF; cl15785 525919003579 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 525919003580 putative ArsC-like catalytic residues; other site 525919003581 putative TRX-like catalytic residues [active] 525919003582 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525919003583 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 525919003584 metal binding site [ion binding]; metal-binding site 525919003585 dimer interface [polypeptide binding]; other site 525919003586 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525919003587 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 525919003588 putative active site [active] 525919003589 metal binding site [ion binding]; metal-binding site 525919003590 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 525919003591 threonine dehydratase; Provisional; Region: PRK08198 525919003592 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 525919003593 tetramer interface [polypeptide binding]; other site 525919003594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919003595 catalytic residue [active] 525919003596 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 525919003597 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 525919003598 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525919003599 dimer interface [polypeptide binding]; other site 525919003600 PYR/PP interface [polypeptide binding]; other site 525919003601 TPP binding site [chemical binding]; other site 525919003602 substrate binding site [chemical binding]; other site 525919003603 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 525919003604 Domain of unknown function; Region: EKR; cl11037 525919003605 4Fe-4S binding domain; Region: Fer4; cl02805 525919003606 4Fe-4S binding domain; Region: Fer4; cl02805 525919003607 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 525919003608 TPP-binding site [chemical binding]; other site 525919003609 dimer interface [polypeptide binding]; other site 525919003610 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919003611 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 525919003612 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 525919003613 NAD binding site [chemical binding]; other site 525919003614 dimer interface [polypeptide binding]; other site 525919003615 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525919003616 substrate binding site [chemical binding]; other site 525919003617 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 525919003618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919003619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525919003620 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 525919003621 MgtE intracellular N domain; Region: MgtE_N; cl15244 525919003622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 525919003623 Divalent cation transporter; Region: MgtE; cl00786 525919003624 Divalent cation transporter; Region: MgtE; cl00786 525919003625 peptidase T; Region: peptidase-T; TIGR01882 525919003626 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 525919003627 metal binding site [ion binding]; metal-binding site 525919003628 dimer interface [polypeptide binding]; other site 525919003629 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 525919003630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919003631 motif II; other site 525919003632 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 525919003633 Maf-like protein; Region: Maf; pfam02545 525919003634 active site 525919003635 dimer interface [polypeptide binding]; other site 525919003636 GMP synthase subunit A; Validated; Region: PRK00758 525919003637 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 525919003638 catalytic triad [active] 525919003639 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 525919003640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525919003641 Helix-turn-helix domains; Region: HTH; cl00088 525919003642 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 525919003643 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 525919003644 homodimer interface [polypeptide binding]; other site 525919003645 putative active site [active] 525919003646 catalytic site [active] 525919003647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003648 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525919003649 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 525919003650 G1 box; other site 525919003651 G1 box; other site 525919003652 GTP/Mg2+ binding site [chemical binding]; other site 525919003653 GTP/Mg2+ binding site [chemical binding]; other site 525919003654 G2 box; other site 525919003655 Switch I region; other site 525919003656 G3 box; other site 525919003657 Switch II region; other site 525919003658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003659 G4 box; other site 525919003660 G4 box; other site 525919003661 G5 box; other site 525919003662 Domain of unknown function (DUF697); Region: DUF697; cl12064 525919003663 EamA-like transporter family; Region: EamA; cl01037 525919003664 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 525919003665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003666 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 525919003667 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 525919003668 DAK2 domain; Region: Dak2; cl03685 525919003669 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 525919003670 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 525919003671 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525919003672 ATP binding site [chemical binding]; other site 525919003673 Mg++ binding site [ion binding]; other site 525919003674 motif III; other site 525919003675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919003676 nucleotide binding region [chemical binding]; other site 525919003677 ATP-binding site [chemical binding]; other site 525919003678 DbpA RNA binding domain; Region: DbpA; pfam03880 525919003679 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 525919003680 C-terminal domain interface [polypeptide binding]; other site 525919003681 GSH binding site (G-site) [chemical binding]; other site 525919003682 dimer interface [polypeptide binding]; other site 525919003683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 525919003684 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 525919003685 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 525919003686 4Fe-4S binding domain; Region: Fer4; cl02805 525919003687 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 525919003688 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 525919003689 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 525919003690 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 525919003691 SLBB domain; Region: SLBB; pfam10531 525919003692 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 525919003693 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525919003694 4Fe-4S binding domain; Region: Fer4; cl02805 525919003695 4Fe-4S binding domain; Region: Fer4; cl02805 525919003696 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 525919003697 putative dimer interface [polypeptide binding]; other site 525919003698 [2Fe-2S] cluster binding site [ion binding]; other site 525919003699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919003700 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 525919003701 Walker A/P-loop; other site 525919003702 ATP binding site [chemical binding]; other site 525919003703 Q-loop/lid; other site 525919003704 ABC transporter signature motif; other site 525919003705 Walker B; other site 525919003706 D-loop; other site 525919003707 H-loop/switch region; other site 525919003708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525919003709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919003710 ATP binding site [chemical binding]; other site 525919003711 Mg2+ binding site [ion binding]; other site 525919003712 G-X-G motif; other site 525919003713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919003714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919003715 active site 525919003716 phosphorylation site [posttranslational modification] 525919003717 intermolecular recognition site; other site 525919003718 dimerization interface [polypeptide binding]; other site 525919003719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919003720 DNA binding site [nucleotide binding] 525919003721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525919003722 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919003723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919003724 FeS/SAM binding site; other site 525919003725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525919003726 Helix-turn-helix domains; Region: HTH; cl00088 525919003727 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525919003728 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 525919003729 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 525919003730 substrate binding site [chemical binding]; other site 525919003731 oxyanion hole (OAH) forming residues; other site 525919003732 trimer interface [polypeptide binding]; other site 525919003733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 525919003734 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 525919003735 Citrate synthase; Region: Citrate_synt; pfam00285 525919003736 oxalacetate binding site [chemical binding]; other site 525919003737 citrylCoA binding site [chemical binding]; other site 525919003738 coenzyme A binding site [chemical binding]; other site 525919003739 catalytic triad [active] 525919003740 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 525919003741 tartrate dehydrogenase; Provisional; Region: PRK08194 525919003742 aconitate hydratase; Validated; Region: PRK07229 525919003743 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 525919003744 substrate binding site [chemical binding]; other site 525919003745 ligand binding site [chemical binding]; other site 525919003746 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 525919003747 substrate binding site [chemical binding]; other site 525919003748 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 525919003749 ATP binding site [chemical binding]; other site 525919003750 active site 525919003751 substrate binding site [chemical binding]; other site 525919003752 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 525919003753 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 525919003754 dimerization interface [polypeptide binding]; other site 525919003755 putative ATP binding site [chemical binding]; other site 525919003756 AIR carboxylase; Region: AIRC; cl00310 525919003757 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 525919003758 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 525919003759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 525919003760 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 525919003761 active site 525919003762 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 525919003763 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 525919003764 ATP-grasp domain; Region: ATP-grasp_4; cl03087 525919003765 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 525919003766 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 525919003767 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 525919003768 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 525919003769 dimerization interface [polypeptide binding]; other site 525919003770 ATP binding site [chemical binding]; other site 525919003771 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 525919003772 dimerization interface [polypeptide binding]; other site 525919003773 ATP binding site [chemical binding]; other site 525919003774 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525919003775 conserved cys residue [active] 525919003776 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 525919003777 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 525919003778 purine monophosphate binding site [chemical binding]; other site 525919003779 dimer interface [polypeptide binding]; other site 525919003780 putative catalytic residues [active] 525919003781 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 525919003782 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 525919003783 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 525919003784 active site 525919003785 substrate binding site [chemical binding]; other site 525919003786 cosubstrate binding site; other site 525919003787 catalytic site [active] 525919003788 amidophosphoribosyltransferase; Provisional; Region: PRK05793 525919003789 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 525919003790 active site 525919003791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525919003792 active site 525919003793 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 525919003794 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 525919003795 Potassium binding sites [ion binding]; other site 525919003796 Cesium cation binding sites [ion binding]; other site 525919003797 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 525919003798 cytosine deaminase; Provisional; Region: PRK09230 525919003799 active site 525919003800 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 525919003801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525919003802 putative substrate translocation pore; other site 525919003803 ThiC family; Region: ThiC; cl08031 525919003804 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 525919003805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525919003806 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919003807 Restriction endonuclease; Region: Mrr_cat; cl00516 525919003808 DNA topoisomerase I, archaeal; Region: topA_arch; TIGR01057 525919003809 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525919003810 G5 domain; Region: G5; pfam07501 525919003811 G5 domain; Region: G5; pfam07501 525919003812 G5 domain; Region: G5; pfam07501 525919003813 G5 domain; Region: G5; pfam07501 525919003814 G5 domain; Region: G5; pfam07501 525919003815 G5 domain; Region: G5; pfam07501 525919003816 G5 domain; Region: G5; pfam07501 525919003817 G5 domain; Region: G5; pfam07501 525919003818 G5 domain; Region: G5; pfam07501 525919003819 G5 domain; Region: G5; pfam07501 525919003820 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 525919003821 Ion channel; Region: Ion_trans_2; cl11596 525919003822 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525919003823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003824 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 525919003825 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 525919003826 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 525919003827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525919003828 Coenzyme A binding pocket [chemical binding]; other site 525919003829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 525919003830 dinuclear metal binding motif [ion binding]; other site 525919003831 4Fe-4S binding domain; Region: Fer4; cl02805 525919003832 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525919003833 4Fe-4S binding domain; Region: Fer4; cl02805 525919003834 PSP1 C-terminal conserved region; Region: PSP1; cl00770 525919003835 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 525919003836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919003837 Nitrogen regulatory protein P-II; Region: P-II; cl00412 525919003838 thymidylate kinase; Validated; Region: tmk; PRK00698 525919003839 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 525919003840 TMP-binding site; other site 525919003841 ATP-binding site [chemical binding]; other site 525919003842 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 525919003843 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 525919003844 5S rRNA interface [nucleotide binding]; other site 525919003845 CTC domain interface [polypeptide binding]; other site 525919003846 L16 interface [polypeptide binding]; other site 525919003847 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 525919003848 dimer interface [polypeptide binding]; other site 525919003849 catalytic triad [active] 525919003850 peroxidatic and resolving cysteines [active] 525919003851 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 525919003852 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 525919003853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003854 NAD(P) binding pocket [chemical binding]; other site 525919003855 Bacterial SH3 domain; Region: SH3_3; cl02551 525919003856 NlpC/P60 family; Region: NLPC_P60; cl11438 525919003857 Uncharacterized conserved protein [Function unknown]; Region: COG0327 525919003858 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 525919003859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003860 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 525919003861 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525919003862 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 525919003863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525919003864 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525919003865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525919003866 DNA binding residues [nucleotide binding] 525919003867 DNA primase, catalytic core; Region: dnaG; TIGR01391 525919003868 CHC2 zinc finger; Region: zf-CHC2; cl15369 525919003869 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 525919003870 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 525919003871 active site 525919003872 metal binding site [ion binding]; metal-binding site 525919003873 interdomain interaction site; other site 525919003874 Cupin domain; Region: Cupin_2; cl09118 525919003875 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525919003876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525919003877 Transporter associated domain; Region: CorC_HlyC; cl08393 525919003878 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 525919003879 elongation factor Tu; Reviewed; Region: PRK00049 525919003880 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525919003881 G1 box; other site 525919003882 GEF interaction site [polypeptide binding]; other site 525919003883 GTP/Mg2+ binding site [chemical binding]; other site 525919003884 Switch I region; other site 525919003885 G2 box; other site 525919003886 G3 box; other site 525919003887 Switch II region; other site 525919003888 G4 box; other site 525919003889 G5 box; other site 525919003890 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525919003891 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525919003892 Antibiotic Binding Site [chemical binding]; other site 525919003893 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 525919003894 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 525919003895 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525919003896 metal binding site 2 [ion binding]; metal-binding site 525919003897 putative DNA binding helix; other site 525919003898 metal binding site 1 [ion binding]; metal-binding site 525919003899 dimer interface [polypeptide binding]; other site 525919003900 structural Zn2+ binding site [ion binding]; other site 525919003901 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 525919003902 core dimer interface [polypeptide binding]; other site 525919003903 peripheral dimer interface [polypeptide binding]; other site 525919003904 L10 interface [polypeptide binding]; other site 525919003905 L11 interface [polypeptide binding]; other site 525919003906 putative EF-Tu interaction site [polypeptide binding]; other site 525919003907 putative EF-G interaction site [polypeptide binding]; other site 525919003908 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 525919003909 23S rRNA interface [nucleotide binding]; other site 525919003910 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 525919003911 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 525919003912 mRNA/rRNA interface [nucleotide binding]; other site 525919003913 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 525919003914 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 525919003915 23S rRNA interface [nucleotide binding]; other site 525919003916 L7/L12 interface [polypeptide binding]; other site 525919003917 putative thiostrepton binding site; other site 525919003918 L25 interface [polypeptide binding]; other site 525919003919 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 525919003920 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 525919003921 putative homodimer interface [polypeptide binding]; other site 525919003922 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 525919003923 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 525919003924 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 525919003925 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 525919003926 active site 525919003927 substrate binding site [chemical binding]; other site 525919003928 metal binding site [ion binding]; metal-binding site 525919003929 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 525919003930 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 525919003931 NAD binding site [chemical binding]; other site 525919003932 catalytic residues [active] 525919003933 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 525919003934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003935 Predicted methyltransferases [General function prediction only]; Region: COG0313 525919003936 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 525919003937 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 525919003938 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525919003939 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 525919003940 homopentamer interface [polypeptide binding]; other site 525919003941 active site 525919003942 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 525919003943 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 525919003944 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 525919003945 dimerization interface [polypeptide binding]; other site 525919003946 active site 525919003947 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 525919003948 Lumazine binding domain; Region: Lum_binding; pfam00677 525919003949 Lumazine binding domain; Region: Lum_binding; pfam00677 525919003950 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 525919003951 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 525919003952 catalytic motif [active] 525919003953 Zn binding site [ion binding]; other site 525919003954 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 525919003955 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 525919003956 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 525919003957 nucleotide binding site/active site [active] 525919003958 HIT family signature motif; other site 525919003959 catalytic residue [active] 525919003960 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 525919003961 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525919003962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919003963 FeS/SAM binding site; other site 525919003964 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 525919003965 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525919003966 HSP70 interaction site [polypeptide binding]; other site 525919003967 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 525919003968 substrate binding site [polypeptide binding]; other site 525919003969 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 525919003970 Zn binding sites [ion binding]; other site 525919003971 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525919003972 dimer interface [polypeptide binding]; other site 525919003973 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 525919003974 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 525919003975 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 525919003976 dimer interface [polypeptide binding]; other site 525919003977 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 525919003978 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 525919003979 Helix-turn-helix domains; Region: HTH; cl00088 525919003980 HrcA protein C terminal domain; Region: HrcA; pfam01628 525919003981 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 525919003982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003983 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 525919003984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 525919003985 FeS/SAM binding site; other site 525919003986 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 525919003987 HemN C-terminal domain; Region: HemN_C; pfam06969 525919003988 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 525919003989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525919003990 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 525919003991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919003992 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 525919003993 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 525919003994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919003995 FeS/SAM binding site; other site 525919003996 HemN C-terminal domain; Region: HemN_C; pfam06969 525919003997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525919003998 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919003999 Cupin domain; Region: Cupin_2; cl09118 525919004000 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 525919004001 FAD binding pocket [chemical binding]; other site 525919004002 conserved FAD binding motif [chemical binding]; other site 525919004003 phosphate binding motif [ion binding]; other site 525919004004 beta-alpha-beta structure motif; other site 525919004005 NAD binding pocket [chemical binding]; other site 525919004006 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 525919004007 putative uracil binding site [chemical binding]; other site 525919004008 putative active site [active] 525919004009 GTP-binding protein LepA; Provisional; Region: PRK05433 525919004010 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 525919004011 G1 box; other site 525919004012 putative GEF interaction site [polypeptide binding]; other site 525919004013 GTP/Mg2+ binding site [chemical binding]; other site 525919004014 Switch I region; other site 525919004015 G2 box; other site 525919004016 G3 box; other site 525919004017 Switch II region; other site 525919004018 G4 box; other site 525919004019 G5 box; other site 525919004020 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 525919004021 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 525919004022 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 525919004023 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525919004024 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525919004025 Catalytic site [active] 525919004026 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 525919004027 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 525919004028 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 525919004029 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 525919004030 Competence protein; Region: Competence; cl00471 525919004031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525919004032 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 525919004033 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525919004035 Walker A/P-loop; other site 525919004036 ATP binding site [chemical binding]; other site 525919004037 Q-loop/lid; other site 525919004038 ABC transporter signature motif; other site 525919004039 Walker B; other site 525919004040 D-loop; other site 525919004041 H-loop/switch region; other site 525919004042 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919004043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004044 Walker A/P-loop; other site 525919004045 ATP binding site [chemical binding]; other site 525919004046 Q-loop/lid; other site 525919004047 ABC transporter signature motif; other site 525919004048 Walker B; other site 525919004049 D-loop; other site 525919004050 H-loop/switch region; other site 525919004051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919004052 non-specific DNA binding site [nucleotide binding]; other site 525919004053 salt bridge; other site 525919004054 sequence-specific DNA binding site [nucleotide binding]; other site 525919004055 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525919004056 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525919004057 SdpI/YhfL protein family; Region: SdpI; pfam13630 525919004058 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 525919004059 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 525919004060 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525919004061 HIGH motif; other site 525919004062 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525919004063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525919004064 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525919004065 active site 525919004066 KMSKS motif; other site 525919004067 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 525919004068 tRNA binding surface [nucleotide binding]; other site 525919004069 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 525919004070 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 525919004071 putative dimer interface [polypeptide binding]; other site 525919004072 putative anticodon binding site; other site 525919004073 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 525919004074 homodimer interface [polypeptide binding]; other site 525919004075 motif 1; other site 525919004076 motif 2; other site 525919004077 active site 525919004078 motif 3; other site 525919004079 recombination factor protein RarA; Reviewed; Region: PRK13342 525919004080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919004081 Walker A motif; other site 525919004082 ATP binding site [chemical binding]; other site 525919004083 Walker B motif; other site 525919004084 arginine finger; other site 525919004085 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 525919004086 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 525919004087 ATP cone domain; Region: ATP-cone; pfam03477 525919004088 cell division protein FtsZ; Validated; Region: PRK09330 525919004089 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 525919004090 nucleotide binding site [chemical binding]; other site 525919004091 SulA interaction site; other site 525919004092 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 525919004093 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 525919004094 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 525919004095 active site 525919004096 homodimer interface [polypeptide binding]; other site 525919004097 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 525919004098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004099 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919004100 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525919004101 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 525919004102 Mg++ binding site [ion binding]; other site 525919004103 putative catalytic motif [active] 525919004104 putative substrate binding site [chemical binding]; other site 525919004105 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 525919004106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004107 cell division protein MraZ; Reviewed; Region: PRK00326 525919004108 MraZ protein; Region: MraZ; pfam02381 525919004109 MraZ protein; Region: MraZ; pfam02381 525919004110 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 525919004111 Transcriptional regulator; Region: Transcrip_reg; cl00361 525919004112 Uncharacterized conserved protein [Function unknown]; Region: COG1739 525919004113 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 525919004114 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 525919004115 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 525919004116 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 525919004117 HflX GTPase family; Region: HflX; cd01878 525919004118 G1 box; other site 525919004119 GTP/Mg2+ binding site [chemical binding]; other site 525919004120 Switch I region; other site 525919004121 G2 box; other site 525919004122 G3 box; other site 525919004123 Switch II region; other site 525919004124 G4 box; other site 525919004125 G5 box; other site 525919004126 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 525919004127 Transglycosylase; Region: Transgly; cl07896 525919004128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919004129 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 525919004130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919004131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919004132 active site 525919004133 phosphorylation site [posttranslational modification] 525919004134 intermolecular recognition site; other site 525919004135 dimerization interface [polypeptide binding]; other site 525919004136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919004137 DNA binding site [nucleotide binding] 525919004138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525919004139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919004140 dimer interface [polypeptide binding]; other site 525919004141 phosphorylation site [posttranslational modification] 525919004142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919004143 ATP binding site [chemical binding]; other site 525919004144 Mg2+ binding site [ion binding]; other site 525919004145 G-X-G motif; other site 525919004146 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525919004147 Active site serine [active] 525919004148 AAA domain; Region: AAA_13; pfam13166 525919004149 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 525919004150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919004151 ATP binding site [chemical binding]; other site 525919004152 putative Mg++ binding site [ion binding]; other site 525919004153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919004154 nucleotide binding region [chemical binding]; other site 525919004155 ATP-binding site [chemical binding]; other site 525919004156 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 525919004157 Phosphotransferase enzyme family; Region: APH; pfam01636 525919004158 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 525919004159 active site 525919004160 ATP binding site [chemical binding]; other site 525919004161 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 525919004162 active site 525919004163 ATP binding site [chemical binding]; other site 525919004164 substrate binding site [chemical binding]; other site 525919004165 Transcriptional regulators [Transcription]; Region: MarR; COG1846 525919004166 Helix-turn-helix domains; Region: HTH; cl00088 525919004167 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 525919004168 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 525919004169 putative active site [active] 525919004170 putative metal binding site [ion binding]; other site 525919004171 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 525919004172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919004173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919004174 dimer interface [polypeptide binding]; other site 525919004175 conserved gate region; other site 525919004176 ABC-ATPase subunit interface; other site 525919004177 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525919004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525919004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919004180 putative PBP binding loops; other site 525919004181 dimer interface [polypeptide binding]; other site 525919004182 ABC-ATPase subunit interface; other site 525919004183 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525919004184 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 525919004185 Walker A/P-loop; other site 525919004186 ATP binding site [chemical binding]; other site 525919004187 Q-loop/lid; other site 525919004188 ABC transporter signature motif; other site 525919004189 Walker B; other site 525919004190 D-loop; other site 525919004191 H-loop/switch region; other site 525919004192 TOBE domain; Region: TOBE_2; cl01440 525919004193 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525919004194 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 525919004195 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 525919004196 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 525919004197 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 525919004198 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 525919004199 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525919004200 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 525919004201 NAD binding site [chemical binding]; other site 525919004202 dimer interface [polypeptide binding]; other site 525919004203 substrate binding site [chemical binding]; other site 525919004204 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 525919004205 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919004206 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 525919004207 putative substrate binding pocket [chemical binding]; other site 525919004208 AC domain interface; other site 525919004209 catalytic triad [active] 525919004210 AB domain interface; other site 525919004211 interchain disulfide; other site 525919004212 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 525919004213 Protein of unknown function (DUF979); Region: DUF979; cl01572 525919004214 Protein of unknown function (DUF969); Region: DUF969; cl01573 525919004215 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525919004216 active site residue [active] 525919004217 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 525919004218 DNA-binding site [nucleotide binding]; DNA binding site 525919004219 RNA-binding motif; other site 525919004220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919004221 S-adenosylmethionine binding site [chemical binding]; other site 525919004222 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 525919004223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525919004224 active site 525919004225 HIGH motif; other site 525919004226 nucleotide binding site [chemical binding]; other site 525919004227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525919004228 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 525919004229 active site 525919004230 KMSKS motif; other site 525919004231 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 525919004232 tRNA binding surface [nucleotide binding]; other site 525919004233 anticodon binding site; other site 525919004234 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 525919004235 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 525919004236 pyruvate phosphate dikinase; Provisional; Region: PRK09279 525919004237 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525919004238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 525919004239 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 525919004240 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 525919004241 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 525919004242 NAD(P) binding site [chemical binding]; other site 525919004243 catalytic residues [active] 525919004244 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 525919004245 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 525919004246 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 525919004247 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 525919004248 active site 525919004249 HIGH motif; other site 525919004250 dimer interface [polypeptide binding]; other site 525919004251 KMSKS motif; other site 525919004252 peptide chain release factor 2; Validated; Region: prfB; PRK00578 525919004253 RF-1 domain; Region: RF-1; cl02875 525919004254 RF-1 domain; Region: RF-1; cl02875 525919004255 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 525919004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004257 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 525919004258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919004259 nucleotide binding region [chemical binding]; other site 525919004260 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 525919004261 30S subunit binding site; other site 525919004262 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 525919004263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919004264 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 525919004265 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 525919004266 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 525919004267 substrate binding site [chemical binding]; other site 525919004268 THF binding site; other site 525919004269 zinc-binding site [ion binding]; other site 525919004270 Putative cyclase; Region: Cyclase; cl00814 525919004271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919004272 non-specific DNA binding site [nucleotide binding]; other site 525919004273 salt bridge; other site 525919004274 sequence-specific DNA binding site [nucleotide binding]; other site 525919004275 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 525919004276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004277 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525919004278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004279 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 525919004280 NlpC/P60 family; Region: NLPC_P60; cl11438 525919004281 Bacterial SH3 domain; Region: SH3_3; cl02551 525919004282 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525919004283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 525919004284 NPCBM/NEW2 domain; Region: NPCBM; cl07060 525919004285 FRG domain; Region: FRG; cl07460 525919004286 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 525919004287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525919004288 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 525919004289 ATP-grasp domain; Region: ATP-grasp_4; cl03087 525919004290 Bacterial sugar transferase; Region: Bac_transf; cl00939 525919004291 argininosuccinate lyase; Provisional; Region: PRK02186 525919004292 ATP-grasp domain; Region: ATP-grasp_4; cl03087 525919004293 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525919004294 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525919004295 inhibitor-cofactor binding pocket; inhibition site 525919004296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919004297 catalytic residue [active] 525919004298 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 525919004299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004300 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 525919004301 NAD(P) binding site [chemical binding]; other site 525919004302 homodimer interface [polypeptide binding]; other site 525919004303 substrate binding site [chemical binding]; other site 525919004304 active site 525919004305 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 525919004306 integral membrane protein MviN; Region: mviN; TIGR01695 525919004307 MatE; Region: MatE; cl10513 525919004308 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 525919004309 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 525919004310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 525919004311 hypothetical protein; Provisional; Region: PRK13663 525919004312 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 525919004313 GIY-YIG motif/motif A; other site 525919004314 putative active site [active] 525919004315 putative metal binding site [ion binding]; other site 525919004316 ApbE family; Region: ApbE; cl00643 525919004317 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 525919004318 glycogen branching enzyme; Provisional; Region: PRK12313 525919004319 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 525919004320 active site 525919004321 catalytic site [active] 525919004322 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 525919004323 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 525919004324 Sugar specificity; other site 525919004325 Pyrimidine base specificity; other site 525919004326 ATP-binding site [chemical binding]; other site 525919004327 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 525919004328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004329 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 525919004330 active site 525919004331 metal binding site [ion binding]; metal-binding site 525919004332 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525919004333 nucleoside/Zn binding site; other site 525919004334 dimer interface [polypeptide binding]; other site 525919004335 catalytic motif [active] 525919004336 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 525919004337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919004338 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 525919004339 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 525919004340 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 525919004341 putative active site [active] 525919004342 putative CoA binding site [chemical binding]; other site 525919004343 nudix motif; other site 525919004344 metal binding site [ion binding]; metal-binding site 525919004345 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 525919004346 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 525919004347 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 525919004348 DNA topoisomerase I; Validated; Region: PRK05582 525919004349 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 525919004350 active site 525919004351 interdomain interaction site; other site 525919004352 putative metal-binding site [ion binding]; other site 525919004353 nucleotide binding site [chemical binding]; other site 525919004354 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525919004355 domain I; other site 525919004356 DNA binding groove [nucleotide binding] 525919004357 phosphate binding site [ion binding]; other site 525919004358 domain II; other site 525919004359 domain III; other site 525919004360 nucleotide binding site [chemical binding]; other site 525919004361 catalytic site [active] 525919004362 domain IV; other site 525919004363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525919004364 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525919004365 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 525919004366 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 525919004367 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 525919004368 Restriction endonuclease; Region: Mrr_cat; cl00516 525919004369 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 525919004370 RNA/DNA hybrid binding site [nucleotide binding]; other site 525919004371 active site 525919004372 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 525919004373 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 525919004374 GTP/Mg2+ binding site [chemical binding]; other site 525919004375 G4 box; other site 525919004376 G5 box; other site 525919004377 G1 box; other site 525919004378 Switch I region; other site 525919004379 G2 box; other site 525919004380 G3 box; other site 525919004381 Switch II region; other site 525919004382 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525919004383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004384 Walker A/P-loop; other site 525919004385 ATP binding site [chemical binding]; other site 525919004386 Q-loop/lid; other site 525919004387 ABC transporter signature motif; other site 525919004388 Walker B; other site 525919004389 D-loop; other site 525919004390 H-loop/switch region; other site 525919004391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919004392 non-specific DNA binding site [nucleotide binding]; other site 525919004393 salt bridge; other site 525919004394 sequence-specific DNA binding site [nucleotide binding]; other site 525919004395 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 525919004396 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 525919004397 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 525919004398 RimM N-terminal domain; Region: RimM; pfam01782 525919004399 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 525919004400 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 525919004401 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 525919004402 signal recognition particle protein; Provisional; Region: PRK10867 525919004403 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 525919004404 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525919004405 P loop; other site 525919004406 GTP binding site [chemical binding]; other site 525919004407 Signal peptide binding domain; Region: SRP_SPB; pfam02978 525919004408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 525919004409 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 525919004410 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525919004411 protein binding site [polypeptide binding]; other site 525919004412 ABC-2 type transporter; Region: ABC2_membrane; cl11417 525919004413 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525919004414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004415 Walker A/P-loop; other site 525919004416 ATP binding site [chemical binding]; other site 525919004417 Q-loop/lid; other site 525919004418 ABC transporter signature motif; other site 525919004419 Walker B; other site 525919004420 D-loop; other site 525919004421 H-loop/switch region; other site 525919004422 RecX family; Region: RecX; cl00936 525919004423 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 525919004424 GIY-YIG motif/motif A; other site 525919004425 putative active site [active] 525919004426 putative metal binding site [ion binding]; other site 525919004427 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525919004428 RNA binding site [nucleotide binding]; other site 525919004429 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 525919004430 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525919004431 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525919004432 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525919004433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919004434 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919004435 Protein of unknown function (DUF972); Region: DUF972; pfam06156 525919004436 rod shape-determining protein MreC; Region: MreC; pfam04085 525919004437 rod shape-determining protein MreB; Provisional; Region: PRK13930 525919004438 hypothetical protein; Reviewed; Region: PRK00024 525919004439 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 525919004440 MPN+ (JAMM) motif; other site 525919004441 Zinc-binding site [ion binding]; other site 525919004442 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 525919004443 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 525919004444 trimer interface [polypeptide binding]; other site 525919004445 ferredoxin; Validated; Region: PRK07118 525919004446 Putative Fe-S cluster; Region: FeS; pfam04060 525919004447 4Fe-4S binding domain; Region: Fer4; cl02805 525919004448 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 525919004449 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 525919004450 FMN-binding domain; Region: FMN_bind; cl01081 525919004451 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 525919004452 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 525919004453 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 525919004454 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 525919004455 SLBB domain; Region: SLBB; pfam10531 525919004456 4Fe-4S binding domain; Region: Fer4; cl02805 525919004457 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525919004458 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 525919004459 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525919004460 catalytic residue [active] 525919004461 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 525919004462 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 525919004463 CoA-binding site [chemical binding]; other site 525919004464 ATP-binding [chemical binding]; other site 525919004465 DNA polymerase I; Provisional; Region: PRK05755 525919004466 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 525919004467 active site 525919004468 metal binding site 1 [ion binding]; metal-binding site 525919004469 putative 5' ssDNA interaction site; other site 525919004470 metal binding site 3; metal-binding site 525919004471 metal binding site 2 [ion binding]; metal-binding site 525919004472 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 525919004473 putative DNA binding site [nucleotide binding]; other site 525919004474 putative metal binding site [ion binding]; other site 525919004475 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 525919004476 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 525919004477 active site 525919004478 DNA binding site [nucleotide binding] 525919004479 catalytic site [active] 525919004480 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 525919004481 Ligand binding site; other site 525919004482 Putative Catalytic site; other site 525919004483 DXD motif; other site 525919004484 GtrA-like protein; Region: GtrA; cl00971 525919004485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525919004486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525919004487 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525919004488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525919004489 binding surface 525919004490 TPR motif; other site 525919004491 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 525919004492 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 525919004493 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 525919004494 active site 525919004495 HIGH motif; other site 525919004496 KMSK motif region; other site 525919004497 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 525919004498 tRNA binding surface [nucleotide binding]; other site 525919004499 anticodon binding site; other site 525919004500 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 525919004501 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 525919004502 Walker A/P-loop; other site 525919004503 ATP binding site [chemical binding]; other site 525919004504 Q-loop/lid; other site 525919004505 ABC transporter signature motif; other site 525919004506 Walker B; other site 525919004507 D-loop; other site 525919004508 H-loop/switch region; other site 525919004509 Plant ATP synthase F0; Region: YMF19; cl07975 525919004510 Smr domain; Region: Smr; cl02619 525919004511 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525919004512 Peptidase family U32; Region: Peptidase_U32; cl03113 525919004513 Collagenase; Region: DUF3656; pfam12392 525919004514 Cell division protein ZapA; Region: ZapA; cl01146 525919004515 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525919004516 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525919004517 putative tRNA-binding site [nucleotide binding]; other site 525919004518 B3/4 domain; Region: B3_4; cl11458 525919004519 tRNA synthetase B5 domain; Region: B5; cl08394 525919004520 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 525919004521 dimer interface [polypeptide binding]; other site 525919004522 motif 1; other site 525919004523 motif 3; other site 525919004524 motif 2; other site 525919004525 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 525919004526 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 525919004527 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 525919004528 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 525919004529 dimer interface [polypeptide binding]; other site 525919004530 motif 1; other site 525919004531 active site 525919004532 motif 2; other site 525919004533 motif 3; other site 525919004534 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525919004535 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 525919004536 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 525919004537 ribosomal protein L20; Region: rpl20; CHL00068 525919004538 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 525919004539 23S rRNA binding site [nucleotide binding]; other site 525919004540 L21 binding site [polypeptide binding]; other site 525919004541 L13 binding site [polypeptide binding]; other site 525919004542 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 525919004543 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 525919004544 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 525919004545 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 525919004546 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525919004547 Helix-turn-helix domains; Region: HTH; cl00088 525919004548 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 525919004549 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 525919004550 putative deacylase active site [active] 525919004551 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 525919004552 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 525919004553 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 525919004554 putative acyltransferase; Provisional; Region: PRK05790 525919004555 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 525919004556 dimer interface [polypeptide binding]; other site 525919004557 active site 525919004558 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 525919004559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004560 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 525919004561 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 525919004562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 525919004563 substrate binding site [chemical binding]; other site 525919004564 oxyanion hole (OAH) forming residues; other site 525919004565 trimer interface [polypeptide binding]; other site 525919004566 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 525919004567 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 525919004568 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 525919004569 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 525919004570 Ligand binding site [chemical binding]; other site 525919004571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 525919004572 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 525919004573 FAD binding site [chemical binding]; other site 525919004574 homotetramer interface [polypeptide binding]; other site 525919004575 substrate binding pocket [chemical binding]; other site 525919004576 catalytic base [active] 525919004577 FAD binding domain; Region: FAD_binding_4; pfam01565 525919004578 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 525919004579 LrgA family; Region: LrgA; cl00608 525919004580 LrgB-like family; Region: LrgB; cl00596 525919004581 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525919004582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525919004583 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 525919004584 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525919004585 DNA binding residues [nucleotide binding] 525919004586 drug binding residues [chemical binding]; other site 525919004587 dimer interface [polypeptide binding]; other site 525919004588 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 525919004589 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 525919004590 non-heme iron binding site [ion binding]; other site 525919004591 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 525919004592 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 525919004593 dimer interface [polypeptide binding]; other site 525919004594 motif 1; other site 525919004595 active site 525919004596 motif 2; other site 525919004597 motif 3; other site 525919004598 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 525919004599 anticodon binding site; other site 525919004600 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919004601 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919004602 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 525919004603 Walker A/P-loop; other site 525919004604 ATP binding site [chemical binding]; other site 525919004605 Q-loop/lid; other site 525919004606 ABC transporter signature motif; other site 525919004607 Walker B; other site 525919004608 D-loop; other site 525919004609 H-loop/switch region; other site 525919004610 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919004611 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 525919004612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004613 Walker A/P-loop; other site 525919004614 ATP binding site [chemical binding]; other site 525919004615 Q-loop/lid; other site 525919004616 ABC transporter signature motif; other site 525919004617 Walker B; other site 525919004618 D-loop; other site 525919004619 H-loop/switch region; other site 525919004620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525919004621 Helix-turn-helix domains; Region: HTH; cl00088 525919004622 Helix-turn-helix domains; Region: HTH; cl00088 525919004623 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004624 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 525919004625 metal ion-dependent adhesion site (MIDAS); other site 525919004626 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 525919004627 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 525919004628 4Fe-4S binding domain; Region: Fer4; cl02805 525919004629 4Fe-4S binding domain; Region: Fer4; cl02805 525919004630 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 525919004631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525919004632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525919004633 dimer interface [polypeptide binding]; other site 525919004634 phosphorylation site [posttranslational modification] 525919004635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525919004636 ATP binding site [chemical binding]; other site 525919004637 Mg2+ binding site [ion binding]; other site 525919004638 G-X-G motif; other site 525919004639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525919004640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919004641 active site 525919004642 phosphorylation site [posttranslational modification] 525919004643 intermolecular recognition site; other site 525919004644 dimerization interface [polypeptide binding]; other site 525919004645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525919004646 DNA binding site [nucleotide binding] 525919004647 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525919004648 PhoU domain; Region: PhoU; pfam01895 525919004649 PhoU domain; Region: PhoU; pfam01895 525919004650 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 525919004651 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 525919004652 Walker A/P-loop; other site 525919004653 ATP binding site [chemical binding]; other site 525919004654 Q-loop/lid; other site 525919004655 ABC transporter signature motif; other site 525919004656 Walker B; other site 525919004657 D-loop; other site 525919004658 H-loop/switch region; other site 525919004659 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 525919004660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919004661 dimer interface [polypeptide binding]; other site 525919004662 conserved gate region; other site 525919004663 ABC-ATPase subunit interface; other site 525919004664 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 525919004665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919004666 dimer interface [polypeptide binding]; other site 525919004667 conserved gate region; other site 525919004668 putative PBP binding loops; other site 525919004669 ABC-ATPase subunit interface; other site 525919004670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919004671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919004672 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 525919004673 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525919004674 substrate binding site [chemical binding]; other site 525919004675 ATP binding site [chemical binding]; other site 525919004676 DctM-like transporters; Region: DctM; pfam06808 525919004677 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 525919004678 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 525919004679 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525919004680 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 525919004681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525919004682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525919004683 DNA binding site [nucleotide binding] 525919004684 domain linker motif; other site 525919004685 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525919004686 dimerization interface [polypeptide binding]; other site 525919004687 ligand binding site [chemical binding]; other site 525919004688 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 525919004689 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525919004690 minor groove reading motif; other site 525919004691 helix-hairpin-helix signature motif; other site 525919004692 substrate binding pocket [chemical binding]; other site 525919004693 active site 525919004694 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 525919004695 active site 525919004696 catalytic site [active] 525919004697 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 525919004698 C-terminal domain interface [polypeptide binding]; other site 525919004699 GSH binding site (G-site) [chemical binding]; other site 525919004700 dimer interface [polypeptide binding]; other site 525919004701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919004702 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919004703 active site 525919004704 motif I; other site 525919004705 motif II; other site 525919004706 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919004707 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 525919004708 active site 525919004709 catalytic residues [active] 525919004710 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 525919004711 Ferritin-like domain; Region: Ferritin; pfam00210 525919004712 ferroxidase diiron center [ion binding]; other site 525919004713 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525919004714 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 525919004715 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 525919004716 23S rRNA interface [nucleotide binding]; other site 525919004717 L3 interface [polypeptide binding]; other site 525919004718 Sodium:solute symporter family; Region: SSF; cl00456 525919004719 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525919004720 dimer interface [polypeptide binding]; other site 525919004721 substrate binding site [chemical binding]; other site 525919004722 ATP binding site [chemical binding]; other site 525919004723 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525919004724 Cation transport protein; Region: TrkH; cl10514 525919004725 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 525919004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004727 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 525919004728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004729 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 525919004730 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 525919004731 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 525919004732 Isochorismatase family; Region: Isochorismatase; pfam00857 525919004733 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 525919004734 catalytic triad [active] 525919004735 dimer interface [polypeptide binding]; other site 525919004736 conserved cis-peptide bond; other site 525919004737 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525919004738 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 525919004739 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 525919004740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919004742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525919004743 active site 525919004744 motif I; other site 525919004745 motif II; other site 525919004746 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919004747 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 525919004748 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 525919004749 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 525919004750 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 525919004751 excinuclease ABC subunit B; Provisional; Region: PRK05298 525919004752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919004753 ATP binding site [chemical binding]; other site 525919004754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919004755 nucleotide binding region [chemical binding]; other site 525919004756 ATP-binding site [chemical binding]; other site 525919004757 Ultra-violet resistance protein B; Region: UvrB; pfam12344 525919004758 UvrB/uvrC motif; Region: UVR; pfam02151 525919004759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525919004760 dimerization interface [polypeptide binding]; other site 525919004761 putative DNA binding site [nucleotide binding]; other site 525919004762 putative Zn2+ binding site [ion binding]; other site 525919004763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525919004764 metal-binding site [ion binding] 525919004765 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 525919004766 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525919004767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525919004768 motif II; other site 525919004769 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 525919004770 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 525919004771 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 525919004772 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 525919004773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525919004774 ATP binding site [chemical binding]; other site 525919004775 putative Mg++ binding site [ion binding]; other site 525919004776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525919004777 nucleotide binding region [chemical binding]; other site 525919004778 ATP-binding site [chemical binding]; other site 525919004779 RQC domain; Region: RQC; cl09632 525919004780 HRDC domain; Region: HRDC; cl02578 525919004781 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 525919004782 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 525919004783 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 525919004784 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 525919004785 dimerization interface 3.5A [polypeptide binding]; other site 525919004786 active site 525919004787 Cobalt transport protein; Region: CbiQ; cl00463 525919004788 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 525919004789 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 525919004790 Walker A/P-loop; other site 525919004791 ATP binding site [chemical binding]; other site 525919004792 Q-loop/lid; other site 525919004793 ABC transporter signature motif; other site 525919004794 Walker B; other site 525919004795 D-loop; other site 525919004796 H-loop/switch region; other site 525919004797 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 525919004798 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 525919004799 Walker A/P-loop; other site 525919004800 ATP binding site [chemical binding]; other site 525919004801 Q-loop/lid; other site 525919004802 ABC transporter signature motif; other site 525919004803 Walker B; other site 525919004804 D-loop; other site 525919004805 H-loop/switch region; other site 525919004806 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 525919004807 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 525919004808 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 525919004809 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 525919004810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004811 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 525919004812 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525919004813 catalytic loop [active] 525919004814 iron binding site [ion binding]; other site 525919004815 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 525919004816 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 525919004817 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 525919004818 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 525919004819 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 525919004820 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 525919004821 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 525919004822 xanthine permease; Region: pbuX; TIGR03173 525919004823 xanthine permease; Region: pbuX; TIGR03173 525919004824 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 525919004825 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 525919004826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525919004827 active site 525919004828 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 525919004829 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 525919004830 carbamate kinase; Reviewed; Region: PRK12686 525919004831 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 525919004832 putative substrate binding site [chemical binding]; other site 525919004833 nucleotide binding site [chemical binding]; other site 525919004834 nucleotide binding site [chemical binding]; other site 525919004835 homodimer interface [polypeptide binding]; other site 525919004836 phenylhydantoinase; Validated; Region: PRK08323 525919004837 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 525919004838 tetramer interface [polypeptide binding]; other site 525919004839 active site 525919004840 Sodium:solute symporter family; Region: SSF; cl00456 525919004841 peptidase; Reviewed; Region: PRK13004 525919004842 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 525919004843 putative metal binding site [ion binding]; other site 525919004844 putative dimer interface [polypeptide binding]; other site 525919004845 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 525919004846 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525919004847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004848 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 525919004849 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 525919004850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919004851 catalytic residue [active] 525919004852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525919004853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919004854 DNA-binding site [nucleotide binding]; DNA binding site 525919004855 FCD domain; Region: FCD; cl11656 525919004856 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 525919004857 MPT binding site; other site 525919004858 trimer interface [polypeptide binding]; other site 525919004859 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525919004860 putative MPT binding site; other site 525919004861 MOSC domain; Region: MOSC; pfam03473 525919004862 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 525919004863 trimer interface [polypeptide binding]; other site 525919004864 dimer interface [polypeptide binding]; other site 525919004865 putative active site [active] 525919004866 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 525919004867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525919004868 FeS/SAM binding site; other site 525919004869 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 525919004870 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 525919004871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004872 Walker A/P-loop; other site 525919004873 ATP binding site [chemical binding]; other site 525919004874 Q-loop/lid; other site 525919004875 ABC transporter signature motif; other site 525919004876 Walker B; other site 525919004877 D-loop; other site 525919004878 H-loop/switch region; other site 525919004879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919004880 dimer interface [polypeptide binding]; other site 525919004881 conserved gate region; other site 525919004882 putative PBP binding loops; other site 525919004883 ABC-ATPase subunit interface; other site 525919004884 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 525919004885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525919004886 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 525919004887 motif 1; other site 525919004888 dimer interface [polypeptide binding]; other site 525919004889 active site 525919004890 motif 2; other site 525919004891 motif 3; other site 525919004892 TraX protein; Region: TraX; cl05434 525919004893 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 525919004894 Gram positive anchor; Region: Gram_pos_anchor; cl15427 525919004895 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004896 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919004897 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004898 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919004899 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004900 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 525919004901 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004902 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004903 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919004904 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004905 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 525919004906 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 525919004907 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 525919004908 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 525919004909 G1 box; other site 525919004910 GTP/Mg2+ binding site [chemical binding]; other site 525919004911 Switch I region; other site 525919004912 G2 box; other site 525919004913 G3 box; other site 525919004914 Switch II region; other site 525919004915 G4 box; other site 525919004916 G5 box; other site 525919004917 Nucleoside recognition; Region: Gate; cl00486 525919004918 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 525919004919 Nucleoside recognition; Region: Gate; cl00486 525919004920 FeoA domain; Region: FeoA; cl00838 525919004921 FeoA domain; Region: FeoA; cl00838 525919004922 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 525919004923 inhibitor binding site; inhibition site 525919004924 Active site flap [active] 525919004925 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 525919004926 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525919004927 Asp23 family; Region: Asp23; cl00574 525919004928 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 525919004929 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525919004930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919004931 Walker A/P-loop; other site 525919004932 ATP binding site [chemical binding]; other site 525919004933 Q-loop/lid; other site 525919004934 ABC transporter signature motif; other site 525919004935 Walker B; other site 525919004936 D-loop; other site 525919004937 H-loop/switch region; other site 525919004938 ABC transporter; Region: ABC_tran_2; pfam12848 525919004939 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 525919004940 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 525919004941 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 525919004942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919004943 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 525919004944 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 525919004945 G1 box; other site 525919004946 putative GEF interaction site [polypeptide binding]; other site 525919004947 GTP/Mg2+ binding site [chemical binding]; other site 525919004948 Switch I region; other site 525919004949 G2 box; other site 525919004950 G3 box; other site 525919004951 Switch II region; other site 525919004952 G4 box; other site 525919004953 G5 box; other site 525919004954 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 525919004955 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 525919004956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 525919004957 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525919004958 Rubredoxin; Region: Rubredoxin; pfam00301 525919004959 iron binding site [ion binding]; other site 525919004960 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525919004961 Rubredoxin; Region: Rubredoxin; pfam00301 525919004962 iron binding site [ion binding]; other site 525919004963 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525919004964 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525919004965 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525919004966 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 525919004967 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 525919004968 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 525919004969 NAD-dependent deacetylase; Provisional; Region: PRK00481 525919004970 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 525919004971 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525919004972 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919004973 Walker A/P-loop; other site 525919004974 ATP binding site [chemical binding]; other site 525919004975 Q-loop/lid; other site 525919004976 ABC transporter signature motif; other site 525919004977 Walker B; other site 525919004978 D-loop; other site 525919004979 H-loop/switch region; other site 525919004980 Predicted transcriptional regulators [Transcription]; Region: COG1725 525919004981 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 525919004982 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 525919004983 active site 525919004984 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 525919004985 active site 525919004986 catalytic site [active] 525919004987 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525919004988 active site 525919004989 catalytic site [active] 525919004990 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 525919004991 active site 525919004992 catalytic site [active] 525919004993 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919004994 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004995 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919004996 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525919004997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 525919004998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525919004999 Predicted dehydrogenase [General function prediction only]; Region: COG0579 525919005000 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 525919005001 glycerol kinase; Provisional; Region: glpK; PRK00047 525919005002 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 525919005003 N- and C-terminal domain interface [polypeptide binding]; other site 525919005004 active site 525919005005 MgATP binding site [chemical binding]; other site 525919005006 catalytic site [active] 525919005007 metal binding site [ion binding]; metal-binding site 525919005008 glycerol binding site [chemical binding]; other site 525919005009 homotetramer interface [polypeptide binding]; other site 525919005010 homodimer interface [polypeptide binding]; other site 525919005011 FBP binding site [chemical binding]; other site 525919005012 protein IIAGlc interface [polypeptide binding]; other site 525919005013 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 525919005014 Bacterial sugar transferase; Region: Bac_transf; cl00939 525919005015 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525919005016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525919005017 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 525919005018 active site 525919005019 uracil binding [chemical binding]; other site 525919005020 Helix-turn-helix domains; Region: HTH; cl00088 525919005021 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525919005022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919005023 Family description; Region: UvrD_C_2; cl15862 525919005024 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 525919005025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 525919005026 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919005027 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 525919005028 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 525919005029 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 525919005030 ring oligomerisation interface [polypeptide binding]; other site 525919005031 ATP/Mg binding site [chemical binding]; other site 525919005032 stacking interactions; other site 525919005033 hinge regions; other site 525919005034 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 525919005035 oligomerisation interface [polypeptide binding]; other site 525919005036 mobile loop; other site 525919005037 roof hairpin; other site 525919005038 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 525919005039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525919005040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919005041 homodimer interface [polypeptide binding]; other site 525919005042 catalytic residue [active] 525919005043 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 525919005044 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 525919005045 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 525919005046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005047 SAF domain; Region: SAF; cl00555 525919005048 flavoprotein, HI0933 family; Region: TIGR00275 525919005049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005050 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 525919005051 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525919005052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525919005053 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525919005054 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 525919005055 catalytic residues [active] 525919005056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919005057 S-adenosylmethionine binding site [chemical binding]; other site 525919005058 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 525919005059 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 525919005060 putative active site [active] 525919005061 putative metal binding site [ion binding]; other site 525919005062 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 525919005063 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525919005064 active site 525919005065 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 525919005066 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 525919005067 active site 525919005068 HIGH motif; other site 525919005069 KMSKS motif; other site 525919005070 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 525919005071 tRNA binding surface [nucleotide binding]; other site 525919005072 anticodon binding site; other site 525919005073 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 525919005074 putative tRNA-binding site [nucleotide binding]; other site 525919005075 dimer interface [polypeptide binding]; other site 525919005076 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 525919005077 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 525919005078 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 525919005079 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 525919005080 active site 525919005081 HIGH motif; other site 525919005082 dimer interface [polypeptide binding]; other site 525919005083 KMSKS motif; other site 525919005084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525919005085 RNA binding surface [nucleotide binding]; other site 525919005086 maltose O-acetyltransferase; Provisional; Region: PRK10092 525919005087 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 525919005088 active site 525919005089 substrate binding site [chemical binding]; other site 525919005090 trimer interface [polypeptide binding]; other site 525919005091 CoA binding site [chemical binding]; other site 525919005092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525919005093 dimerization interface [polypeptide binding]; other site 525919005094 putative DNA binding site [nucleotide binding]; other site 525919005095 putative Zn2+ binding site [ion binding]; other site 525919005096 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919005097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 525919005098 Walker A/P-loop; other site 525919005099 ATP binding site [chemical binding]; other site 525919005100 Q-loop/lid; other site 525919005101 ABC transporter signature motif; other site 525919005102 Walker B; other site 525919005103 D-loop; other site 525919005104 H-loop/switch region; other site 525919005105 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525919005106 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 525919005107 Walker A/P-loop; other site 525919005108 ATP binding site [chemical binding]; other site 525919005109 Q-loop/lid; other site 525919005110 ABC transporter signature motif; other site 525919005111 Walker B; other site 525919005112 D-loop; other site 525919005113 H-loop/switch region; other site 525919005114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525919005115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525919005116 active site 525919005117 phosphorylation site [posttranslational modification] 525919005118 intermolecular recognition site; other site 525919005119 dimerization interface [polypeptide binding]; other site 525919005120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525919005121 DNA binding residues [nucleotide binding] 525919005122 dimerization interface [polypeptide binding]; other site 525919005123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525919005124 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 525919005125 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 525919005126 Walker A/P-loop; other site 525919005127 ATP binding site [chemical binding]; other site 525919005128 Q-loop/lid; other site 525919005129 ABC transporter signature motif; other site 525919005130 Walker B; other site 525919005131 D-loop; other site 525919005132 H-loop/switch region; other site 525919005133 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 525919005134 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 525919005135 Walker A motif; other site 525919005136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919005137 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 525919005138 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 525919005139 Helix-turn-helix domains; Region: HTH; cl00088 525919005140 3H domain; Region: 3H; pfam02829 525919005141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525919005142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525919005143 substrate binding pocket [chemical binding]; other site 525919005144 membrane-bound complex binding site; other site 525919005145 hinge residues; other site 525919005146 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525919005147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919005148 dimer interface [polypeptide binding]; other site 525919005149 conserved gate region; other site 525919005150 putative PBP binding loops; other site 525919005151 ABC-ATPase subunit interface; other site 525919005152 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525919005153 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 525919005154 Walker A/P-loop; other site 525919005155 ATP binding site [chemical binding]; other site 525919005156 Q-loop/lid; other site 525919005157 ABC transporter signature motif; other site 525919005158 Walker B; other site 525919005159 D-loop; other site 525919005160 H-loop/switch region; other site 525919005161 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 525919005162 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 525919005163 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 525919005164 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 525919005165 RNA/DNA hybrid binding site [nucleotide binding]; other site 525919005166 active site 525919005167 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 525919005168 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 525919005169 active site 525919005170 Na/Ca binding site [ion binding]; other site 525919005171 catalytic site [active] 525919005172 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 525919005173 intersubunit interface [polypeptide binding]; other site 525919005174 active site 525919005175 catalytic residue [active] 525919005176 sensory histidine kinase AtoS; Provisional; Region: PRK11360 525919005177 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 525919005178 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 525919005179 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 525919005180 active site turn [active] 525919005181 phosphorylation site [posttranslational modification] 525919005182 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919005183 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 525919005184 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 525919005185 putative active site [active] 525919005186 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 525919005187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 525919005188 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 525919005189 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 525919005190 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 525919005191 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 525919005192 putative active site [active] 525919005193 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919005194 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 525919005195 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 525919005196 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 525919005197 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 525919005198 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 525919005199 alphaNTD - beta interaction site [polypeptide binding]; other site 525919005200 alphaNTD homodimer interface [polypeptide binding]; other site 525919005201 alphaNTD - beta' interaction site [polypeptide binding]; other site 525919005202 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 525919005203 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 525919005204 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 525919005205 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525919005206 RNA binding surface [nucleotide binding]; other site 525919005207 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 525919005208 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 525919005209 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 525919005210 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 525919005211 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 525919005212 rRNA binding site [nucleotide binding]; other site 525919005213 predicted 30S ribosome binding site; other site 525919005214 adenylate kinase; Reviewed; Region: adk; PRK00279 525919005215 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 525919005216 AMP-binding site [chemical binding]; other site 525919005217 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 525919005218 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 525919005219 SecY translocase; Region: SecY; pfam00344 525919005220 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 525919005221 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 525919005222 23S rRNA binding site [nucleotide binding]; other site 525919005223 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 525919005224 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 525919005225 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 525919005226 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 525919005227 5S rRNA interface [nucleotide binding]; other site 525919005228 L27 interface [polypeptide binding]; other site 525919005229 23S rRNA interface [nucleotide binding]; other site 525919005230 L5 interface [polypeptide binding]; other site 525919005231 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 525919005232 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525919005233 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525919005234 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 525919005235 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 525919005236 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 525919005237 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 525919005238 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 525919005239 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 525919005240 KOW motif; Region: KOW; cl00354 525919005241 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 525919005242 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 525919005243 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 525919005244 putative translocon interaction site; other site 525919005245 signal recognition particle (SRP54) interaction site; other site 525919005246 L23 interface [polypeptide binding]; other site 525919005247 trigger factor interaction site; other site 525919005248 23S rRNA interface [nucleotide binding]; other site 525919005249 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 525919005250 23S rRNA interface [nucleotide binding]; other site 525919005251 5S rRNA interface [nucleotide binding]; other site 525919005252 putative antibiotic binding site [chemical binding]; other site 525919005253 L25 interface [polypeptide binding]; other site 525919005254 L27 interface [polypeptide binding]; other site 525919005255 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 525919005256 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 525919005257 G-X-X-G motif; other site 525919005258 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 525919005259 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 525919005260 putative translocon binding site; other site 525919005261 protein-rRNA interface [nucleotide binding]; other site 525919005262 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 525919005263 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 525919005264 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 525919005265 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 525919005266 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 525919005267 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 525919005268 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 525919005269 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 525919005270 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 525919005271 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 525919005272 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 525919005273 Predicted membrane protein [Function unknown]; Region: COG4905 525919005274 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 525919005275 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 525919005276 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005277 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005278 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919005279 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005280 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005281 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005282 G5 domain; Region: G5; pfam07501 525919005283 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005284 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 525919005285 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005286 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005287 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005288 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 525919005289 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525919005290 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525919005291 ligand binding site [chemical binding]; other site 525919005292 flexible hinge region; other site 525919005293 Helix-turn-helix domains; Region: HTH; cl00088 525919005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525919005295 putative substrate translocation pore; other site 525919005296 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 525919005297 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919005298 substrate binding pocket [chemical binding]; other site 525919005299 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 525919005300 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 525919005301 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 525919005302 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 525919005303 P-loop; other site 525919005304 active site 525919005305 phosphorylation site [posttranslational modification] 525919005306 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 525919005307 methionine cluster; other site 525919005308 active site 525919005309 phosphorylation site [posttranslational modification] 525919005310 metal binding site [ion binding]; metal-binding site 525919005311 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 525919005312 Helix-turn-helix domains; Region: HTH; cl00088 525919005313 PRD domain; Region: PRD; cl15445 525919005314 PRD domain; Region: PRD; cl15445 525919005315 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 525919005316 P-loop; other site 525919005317 active site 525919005318 phosphorylation site [posttranslational modification] 525919005319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 525919005320 active site 525919005321 phosphorylation site [posttranslational modification] 525919005322 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 525919005323 active site 525919005324 ADP/pyrophosphate binding site [chemical binding]; other site 525919005325 dimerization interface [polypeptide binding]; other site 525919005326 allosteric effector site; other site 525919005327 fructose-1,6-bisphosphate binding site; other site 525919005328 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 525919005329 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 525919005330 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 525919005331 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 525919005332 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 525919005333 MFS/sugar transport protein; Region: MFS_2; pfam13347 525919005334 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 525919005335 MFS/sugar transport protein; Region: MFS_2; pfam13347 525919005336 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525919005337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005338 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 525919005339 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 525919005340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525919005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 525919005343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525919005344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005345 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 525919005346 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525919005347 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 525919005348 substrate binding site [chemical binding]; other site 525919005349 ATP binding site [chemical binding]; other site 525919005350 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 525919005351 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 525919005352 active site 525919005353 intersubunit interface [polypeptide binding]; other site 525919005354 catalytic residue [active] 525919005355 Glucuronate isomerase; Region: UxaC; cl00829 525919005356 mannonate dehydratase; Provisional; Region: PRK03906 525919005357 mannonate dehydratase; Region: uxuA; TIGR00695 525919005358 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 525919005359 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 525919005360 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 525919005361 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 525919005362 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 525919005363 Ca binding site [ion binding]; other site 525919005364 active site 525919005365 catalytic site [active] 525919005366 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 525919005367 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 525919005368 Chromate transporter; Region: Chromate_transp; pfam02417 525919005369 Chromate transporter; Region: Chromate_transp; pfam02417 525919005370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 525919005371 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 525919005372 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 525919005373 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 525919005374 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 525919005375 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 525919005376 DctM-like transporters; Region: DctM; pfam06808 525919005377 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 525919005378 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 525919005379 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525919005380 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 525919005381 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 525919005382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 525919005383 putative NAD(P) binding site [chemical binding]; other site 525919005384 catalytic Zn binding site [ion binding]; other site 525919005385 structural Zn binding site [ion binding]; other site 525919005386 Transcriptional regulators [Transcription]; Region: GntR; COG1802 525919005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525919005388 DNA-binding site [nucleotide binding]; DNA binding site 525919005389 FCD domain; Region: FCD; cl11656 525919005390 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 525919005391 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525919005392 TPP-binding site [chemical binding]; other site 525919005393 dimer interface [polypeptide binding]; other site 525919005394 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525919005395 PYR/PP interface [polypeptide binding]; other site 525919005396 dimer interface [polypeptide binding]; other site 525919005397 TPP binding site [chemical binding]; other site 525919005398 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525919005399 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 525919005400 active site 525919005401 intersubunit interactions; other site 525919005402 catalytic residue [active] 525919005403 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 525919005404 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 525919005405 ligand binding site [chemical binding]; other site 525919005406 dimerization interface [polypeptide binding]; other site 525919005407 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 525919005408 TM-ABC transporter signature motif; other site 525919005409 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 525919005410 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 525919005411 Walker A/P-loop; other site 525919005412 ATP binding site [chemical binding]; other site 525919005413 Q-loop/lid; other site 525919005414 ABC transporter signature motif; other site 525919005415 Walker B; other site 525919005416 D-loop; other site 525919005417 H-loop/switch region; other site 525919005418 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 525919005419 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 525919005420 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525919005421 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 525919005422 substrate binding site [chemical binding]; other site 525919005423 dimer interface [polypeptide binding]; other site 525919005424 ATP binding site [chemical binding]; other site 525919005425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525919005426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525919005427 DNA binding site [nucleotide binding] 525919005428 domain linker motif; other site 525919005429 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525919005430 dimerization interface [polypeptide binding]; other site 525919005431 ligand binding site [chemical binding]; other site 525919005432 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 525919005433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525919005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525919005435 homodimer interface [polypeptide binding]; other site 525919005436 catalytic residue [active] 525919005437 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 525919005438 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 525919005439 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 525919005440 folate binding site [chemical binding]; other site 525919005441 NADP+ binding site [chemical binding]; other site 525919005442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525919005443 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525919005444 thiamine phosphate binding site [chemical binding]; other site 525919005445 active site 525919005446 pyrophosphate binding site [ion binding]; other site 525919005447 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525919005448 substrate binding site [chemical binding]; other site 525919005449 multimerization interface [polypeptide binding]; other site 525919005450 ATP binding site [chemical binding]; other site 525919005451 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 525919005452 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 525919005453 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 525919005454 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 525919005455 ThiS interaction site; other site 525919005456 putative active site [active] 525919005457 tetramer interface [polypeptide binding]; other site 525919005458 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 525919005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005460 ATP binding site [chemical binding]; other site 525919005461 substrate interface [chemical binding]; other site 525919005462 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 525919005463 thiS-thiF/thiG interaction site; other site 525919005464 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 525919005465 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525919005466 trimerization site [polypeptide binding]; other site 525919005467 active site 525919005468 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 525919005469 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 525919005470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525919005471 catalytic residue [active] 525919005472 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 525919005473 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 525919005474 FeS assembly protein SufB; Region: sufB; TIGR01980 525919005475 FeS assembly ATPase SufC; Region: sufC; TIGR01978 525919005476 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 525919005477 Walker A/P-loop; other site 525919005478 ATP binding site [chemical binding]; other site 525919005479 Q-loop/lid; other site 525919005480 ABC transporter signature motif; other site 525919005481 Walker B; other site 525919005482 D-loop; other site 525919005483 H-loop/switch region; other site 525919005484 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 525919005485 dimerization domain swap beta strand [polypeptide binding]; other site 525919005486 regulatory protein interface [polypeptide binding]; other site 525919005487 active site 525919005488 regulatory phosphorylation site [posttranslational modification]; other site 525919005489 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 525919005490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525919005491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525919005492 DNA binding residues [nucleotide binding] 525919005493 YacP-like NYN domain; Region: NYN_YacP; cl01491 525919005494 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 525919005495 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 525919005496 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 525919005497 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 525919005498 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525919005499 active site 525919005500 HIGH motif; other site 525919005501 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525919005502 KMSKS motif; other site 525919005503 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525919005504 tRNA binding surface [nucleotide binding]; other site 525919005505 anticodon binding site; other site 525919005506 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525919005507 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525919005508 active site 525919005509 HIGH motif; other site 525919005510 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525919005511 active site 525919005512 KMSKS motif; other site 525919005513 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 525919005514 oligoendopeptidase F; Region: pepF; TIGR00181 525919005515 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 525919005516 Zn binding site [ion binding]; other site 525919005517 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 525919005518 LytTr DNA-binding domain; Region: LytTR; cl04498 525919005519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525919005520 non-specific DNA binding site [nucleotide binding]; other site 525919005521 sequence-specific DNA binding site [nucleotide binding]; other site 525919005522 salt bridge; other site 525919005523 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 525919005524 active site 525919005525 trimer interface [polypeptide binding]; other site 525919005526 allosteric site; other site 525919005527 active site lid [active] 525919005528 hexamer (dimer of trimers) interface [polypeptide binding]; other site 525919005529 Rubrerythrin [Energy production and conversion]; Region: COG1592 525919005530 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 525919005531 binuclear metal center [ion binding]; other site 525919005532 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 525919005533 iron binding site [ion binding]; other site 525919005534 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 525919005535 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 525919005536 active site 525919005537 dimer interface [polypeptide binding]; other site 525919005538 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 525919005539 dimer interface [polypeptide binding]; other site 525919005540 active site 525919005541 CAAX protease self-immunity; Region: Abi; cl00558 525919005542 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525919005543 MatE; Region: MatE; cl10513 525919005544 MatE; Region: MatE; cl10513 525919005545 ATP-grasp domain; Region: ATP-grasp_4; cl03087 525919005546 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 525919005547 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 525919005548 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 525919005549 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 525919005550 active site 525919005551 dimer interface [polypeptide binding]; other site 525919005552 motif 1; other site 525919005553 motif 2; other site 525919005554 motif 3; other site 525919005555 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 525919005556 anticodon binding site; other site 525919005557 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525919005558 active pocket/dimerization site; other site 525919005559 active site 525919005560 phosphorylation site [posttranslational modification] 525919005561 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 525919005562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919005563 dimer interface [polypeptide binding]; other site 525919005564 conserved gate region; other site 525919005565 putative PBP binding loops; other site 525919005566 ABC-ATPase subunit interface; other site 525919005567 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525919005568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525919005569 dimer interface [polypeptide binding]; other site 525919005570 conserved gate region; other site 525919005571 putative PBP binding loops; other site 525919005572 ABC-ATPase subunit interface; other site 525919005573 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 525919005574 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 525919005575 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 525919005576 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 525919005577 Walker A/P-loop; other site 525919005578 ATP binding site [chemical binding]; other site 525919005579 Q-loop/lid; other site 525919005580 ABC transporter signature motif; other site 525919005581 Walker B; other site 525919005582 D-loop; other site 525919005583 H-loop/switch region; other site 525919005584 TOBE domain; Region: TOBE_2; cl01440 525919005585 UDP-glucose 4-epimerase; Region: PLN02240 525919005586 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 525919005587 NAD binding site [chemical binding]; other site 525919005588 homodimer interface [polypeptide binding]; other site 525919005589 active site 525919005590 substrate binding site [chemical binding]; other site 525919005591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525919005592 active site 525919005593 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 525919005594 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 525919005595 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 525919005596 active site 525919005597 phosphorylation site [posttranslational modification] 525919005598 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 525919005599 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525919005600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525919005601 active site residue [active] 525919005602 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 525919005603 Pirin-related protein [General function prediction only]; Region: COG1741 525919005604 Cupin domain; Region: Cupin_2; cl09118 525919005605 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 525919005606 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525919005607 Helix-turn-helix domains; Region: HTH; cl00088 525919005608 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 525919005609 OPT oligopeptide transporter protein; Region: OPT; cl14607 525919005610 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 525919005611 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525919005612 Domain of unknown function DUF21; Region: DUF21; pfam01595 525919005613 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525919005614 Transporter associated domain; Region: CorC_HlyC; cl08393 525919005615 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 525919005616 ATP synthase subunit D; Region: ATP-synt_D; cl00613 525919005617 V-type ATP synthase subunit B; Provisional; Region: PRK04196 525919005618 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 525919005619 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 525919005620 Walker A motif homologous position; other site 525919005621 Walker B motif; other site 525919005622 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525919005623 V-type ATP synthase subunit A; Provisional; Region: PRK04192 525919005624 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 525919005625 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 525919005626 Walker A motif/ATP binding site; other site 525919005627 Walker B motif; other site 525919005628 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525919005629 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 525919005630 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 525919005631 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 525919005632 Plant ATP synthase F0; Region: YMF19; cl07975 525919005633 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 525919005634 V-type ATP synthase subunit K; Validated; Region: PRK06558 525919005635 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525919005636 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525919005637 V-type ATP synthase subunit I; Validated; Region: PRK05771 525919005638 Plant ATP synthase F0; Region: YMF19; cl07975 525919005639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525919005640 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 525919005641 putative ADP-binding pocket [chemical binding]; other site 525919005642 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 525919005643 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 525919005644 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 525919005645 dimer interface [polypeptide binding]; other site 525919005646 putative radical transfer pathway; other site 525919005647 diiron center [ion binding]; other site 525919005648 tyrosyl radical; other site 525919005649 Membrane protein of unknown function; Region: DUF360; cl00850 525919005650 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364 525919005651 ATP cone domain; Region: ATP-cone; pfam03477 525919005652 Class I ribonucleotide reductase; Region: RNR_I; cd01679 525919005653 active site 525919005654 dimer interface [polypeptide binding]; other site 525919005655 catalytic residues [active] 525919005656 effector binding site; other site 525919005657 R2 peptide binding site; other site 525919005658 RDD family; Region: RDD; cl00746 525919005659 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 525919005660 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 525919005661 tandem repeat interface [polypeptide binding]; other site 525919005662 oligomer interface [polypeptide binding]; other site 525919005663 active site residues [active] 525919005664 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 525919005665 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 525919005666 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 525919005667 Ligand Binding Site [chemical binding]; other site 525919005668 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 525919005669 AIR carboxylase; Region: AIRC; cl00310 525919005670 Protein of unknown function DUF111; Region: DUF111; cl03398 525919005671 Protein of unknown function DUF111; Region: DUF111; cl03398 525919005672 Protein of unknown function DUF111; Region: DUF111; cl03398 525919005673 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 525919005674 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525919005675 intersubunit interface [polypeptide binding]; other site 525919005676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525919005677 ABC-ATPase subunit interface; other site 525919005678 dimer interface [polypeptide binding]; other site 525919005679 putative PBP binding regions; other site 525919005680 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525919005681 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525919005682 Walker A/P-loop; other site 525919005683 ATP binding site [chemical binding]; other site 525919005684 Q-loop/lid; other site 525919005685 ABC transporter signature motif; other site 525919005686 Walker B; other site 525919005687 D-loop; other site 525919005688 H-loop/switch region; other site 525919005689 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 525919005690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 525919005691 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 525919005692 nucleophilic elbow; other site 525919005693 catalytic triad; other site 525919005694 Nucleoside recognition; Region: Gate; cl00486 525919005695 FtsH Extracellular; Region: FtsH_ext; pfam06480 525919005696 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 525919005697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525919005698 Walker A motif; other site 525919005699 ATP binding site [chemical binding]; other site 525919005700 Walker B motif; other site 525919005701 arginine finger; other site 525919005702 Peptidase family M41; Region: Peptidase_M41; pfam01434 525919005703 Helix-turn-helix domains; Region: HTH; cl00088 525919005704 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 525919005705 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525919005706 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525919005707 catalytic residues [active] 525919005708 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 525919005709 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 525919005710 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 525919005711 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 525919005712 ParB-like nuclease domain; Region: ParBc; cl02129 525919005713 ParB-like partition proteins; Region: parB_part; TIGR00180 525919005714 KorB domain; Region: KorB; pfam08535 525919005715 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525919005716 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525919005717 P-loop; other site 525919005718 Magnesium ion binding site [ion binding]; other site 525919005719 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525919005720 Magnesium ion binding site [ion binding]; other site 525919005721 competence damage-inducible protein A; Provisional; Region: PRK00549 525919005722 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 525919005723 putative MPT binding site; other site 525919005724 Competence-damaged protein; Region: CinA; cl00666 525919005725 CAAX protease self-immunity; Region: Abi; cl00558 525919005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525919005727 S-adenosylmethionine binding site [chemical binding]; other site 525919005728 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 525919005729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525919005730 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 525919005731 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 525919005732 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 525919005733 trmE is a tRNA modification GTPase; Region: trmE; cd04164 525919005734 G1 box; other site 525919005735 GTP/Mg2+ binding site [chemical binding]; other site 525919005736 Switch I region; other site 525919005737 G2 box; other site 525919005738 Switch II region; other site 525919005739 G3 box; other site 525919005740 G4 box; other site 525919005741 G5 box; other site 525919005742 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 525919005743 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 525919005744 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525919005745 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525919005746 PhoU domain; Region: PhoU; pfam01895 525919005747 PhoU domain; Region: PhoU; pfam01895 525919005748 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 525919005749 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 525919005750 RxxxH motif; other site 525919005751 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 525919005752 Haemolytic domain; Region: Haemolytic; cl00506 525919005753 Ribonuclease P; Region: Ribonuclease_P; cl00457 525919005754 Ribosomal protein L34; Region: Ribosomal_L34; cl00370