-- dump date   	20120504_133037
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
447217000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
447217000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
447217000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000004	Walker A motif; other site
447217000005	ATP binding site [chemical binding]; other site
447217000006	Walker B motif; other site
447217000007	arginine finger; other site
447217000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
447217000009	DnaA box-binding interface [nucleotide binding]; other site
447217000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
447217000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
447217000012	putative DNA binding surface [nucleotide binding]; other site
447217000013	dimer interface [polypeptide binding]; other site
447217000014	beta-clamp/clamp loader binding surface; other site
447217000015	beta-clamp/translesion DNA polymerase binding surface; other site
447217000016	recombination protein F; Reviewed; Region: recF; PRK00064
447217000017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000018	Walker A/P-loop; other site
447217000019	ATP binding site [chemical binding]; other site
447217000020	Q-loop/lid; other site
447217000021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000022	ABC transporter signature motif; other site
447217000023	Walker B; other site
447217000024	D-loop; other site
447217000025	H-loop/switch region; other site
447217000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
447217000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000028	ATP binding site [chemical binding]; other site
447217000029	Mg2+ binding site [ion binding]; other site
447217000030	G-X-G motif; other site
447217000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
447217000032	anchoring element; other site
447217000033	dimer interface [polypeptide binding]; other site
447217000034	ATP binding site [chemical binding]; other site
447217000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
447217000036	active site
447217000037	putative metal-binding site [ion binding]; other site
447217000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
447217000039	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
447217000040	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
447217000041	dimer interface [polypeptide binding]; other site
447217000042	active site
447217000043	CoA binding pocket [chemical binding]; other site
447217000044	Peptidase family M54; Region: Peptidase_M54; cl00835
447217000045	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217000046	Cysteine-rich domain; Region: CCG; pfam02754
447217000047	Cysteine-rich domain; Region: CCG; pfam02754
447217000048	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
447217000049	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217000050	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
447217000051	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217000052	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
447217000053	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217000054	active site
447217000055	HIGH motif; other site
447217000056	nucleotide binding site [chemical binding]; other site
447217000057	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
447217000058	active site
447217000059	KMSKS motif; other site
447217000060	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
447217000061	tRNA binding surface [nucleotide binding]; other site
447217000062	anticodon binding site; other site
447217000063	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217000064	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
447217000065	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
447217000066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217000067	salt bridge; other site
447217000068	non-specific DNA binding site [nucleotide binding]; other site
447217000069	sequence-specific DNA binding site [nucleotide binding]; other site
447217000070	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
447217000071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000072	dimer interface [polypeptide binding]; other site
447217000073	phosphorylation site [posttranslational modification]
447217000074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000075	ATP binding site [chemical binding]; other site
447217000076	Mg2+ binding site [ion binding]; other site
447217000077	G-X-G motif; other site
447217000078	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217000079	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217000080	active site
447217000081	metal binding site [ion binding]; metal-binding site
447217000082	prolyl-tRNA synthetase; Provisional; Region: PRK08661
447217000083	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
447217000084	dimer interface [polypeptide binding]; other site
447217000085	motif 1; other site
447217000086	active site
447217000087	motif 2; other site
447217000088	motif 3; other site
447217000089	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
447217000090	anticodon binding site; other site
447217000091	zinc-binding site [ion binding]; other site
447217000092	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
447217000093	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
447217000094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000095	NAD(P) binding site [chemical binding]; other site
447217000096	active site
447217000097	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000098	Helix-turn-helix domains; Region: HTH; cl00088
447217000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217000100	dimerization interface [polypeptide binding]; other site
447217000101	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000102	dimer interface [polypeptide binding]; other site
447217000103	putative CheW interface [polypeptide binding]; other site
447217000104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000105	NAD(P) binding site [chemical binding]; other site
447217000106	active site
447217000107	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217000108	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
447217000109	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
447217000110	Sodium:solute symporter family; Region: SSF; cl00456
447217000111	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217000112	AMP-binding enzyme; Region: AMP-binding; cl15778
447217000113	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
447217000114	ACT domain-containing protein [General function prediction only]; Region: COG4747
447217000115	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
447217000116	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
447217000117	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
447217000118	AMP-binding enzyme; Region: AMP-binding; cl15778
447217000119	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
447217000120	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217000121	PYR/PP interface [polypeptide binding]; other site
447217000122	TPP binding site [chemical binding]; other site
447217000123	dimer interface [polypeptide binding]; other site
447217000124	substrate binding site [chemical binding]; other site
447217000125	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
447217000126	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
447217000127	TPP-binding site; other site
447217000128	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
447217000129	Acetokinase family; Region: Acetate_kinase; cl01029
447217000130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
447217000131	DNA-binding site [nucleotide binding]; DNA binding site
447217000132	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217000133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217000134	homodimer interface [polypeptide binding]; other site
447217000135	catalytic residue [active]
447217000136	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217000137	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
447217000138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217000139	Coenzyme A binding pocket [chemical binding]; other site
447217000140	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217000141	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
447217000142	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
447217000143	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
447217000144	Ligand binding site [chemical binding]; other site
447217000145	Electron transfer flavoprotein domain; Region: ETF; pfam01012
447217000146	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
447217000147	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
447217000148	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
447217000149	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217000150	Integral membrane protein TerC family; Region: TerC; cl10468
447217000151	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217000152	EamA-like transporter family; Region: EamA; cl01037
447217000153	EamA-like transporter family; Region: EamA; cl01037
447217000154	MltA specific insert domain; Region: MltA; cl08398
447217000155	3D domain; Region: 3D; cl01439
447217000156	uracil transporter; Provisional; Region: PRK10720
447217000157	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
447217000158	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
447217000159	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217000160	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217000161	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217000162	RNA binding surface [nucleotide binding]; other site
447217000163	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217000164	active site
447217000165	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
447217000166	Transglycosylase; Region: Transgly; cl07896
447217000167	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217000168	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217000169	dimerization interface [polypeptide binding]; other site
447217000170	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000171	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217000172	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000173	dimer interface [polypeptide binding]; other site
447217000174	putative CheW interface [polypeptide binding]; other site
447217000175	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000176	dimer interface [polypeptide binding]; other site
447217000177	putative CheW interface [polypeptide binding]; other site
447217000178	EVE domain; Region: EVE; cl00728
447217000179	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
447217000180	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
447217000181	putative acyltransferase; Provisional; Region: PRK05790
447217000182	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217000183	dimer interface [polypeptide binding]; other site
447217000184	active site
447217000185	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
447217000186	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
447217000187	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217000188	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
447217000189	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
447217000190	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
447217000191	oxyanion hole [active]
447217000192	active site
447217000193	catalytic triad [active]
447217000194	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217000195	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
447217000196	inhibitor-cofactor binding pocket; inhibition site
447217000197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217000198	catalytic residue [active]
447217000199	AAA domain; Region: AAA_26; pfam13500
447217000200	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000201	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
447217000202	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
447217000203	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217000204	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217000205	protein binding site [polypeptide binding]; other site
447217000206	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
447217000207	active site
447217000208	thiamine phosphate binding site [chemical binding]; other site
447217000209	pyrophosphate binding site [ion binding]; other site
447217000210	Peptidase C26; Region: Peptidase_C26; pfam07722
447217000211	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
447217000212	catalytic triad [active]
447217000213	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217000214	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
447217000215	replicative DNA helicase; Region: DnaB; TIGR00665
447217000216	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
447217000217	Walker A motif; other site
447217000218	ATP binding site [chemical binding]; other site
447217000219	Walker B motif; other site
447217000220	DNA binding loops [nucleotide binding]
447217000221	Late embryogenesis abundant protein; Region: LEA_2; cl12118
447217000222	Late embryogenesis abundant protein; Region: LEA_2; cl12118
447217000223	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217000224	LrgB-like family; Region: LrgB; cl00596
447217000225	LrgA family; Region: LrgA; cl00608
447217000226	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
447217000227	Helix-turn-helix domains; Region: HTH; cl00088
447217000228	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217000229	dimerization interface [polypeptide binding]; other site
447217000230	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
447217000231	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
447217000232	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
447217000233	substrate binding pocket [chemical binding]; other site
447217000234	dimer interface [polypeptide binding]; other site
447217000235	inhibitor binding site; inhibition site
447217000236	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217000237	B12 binding site [chemical binding]; other site
447217000238	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
447217000239	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
447217000240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000241	FeS/SAM binding site; other site
447217000242	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
447217000243	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
447217000244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000245	dimer interface [polypeptide binding]; other site
447217000246	phosphorylation site [posttranslational modification]
447217000247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000248	ATP binding site [chemical binding]; other site
447217000249	Mg2+ binding site [ion binding]; other site
447217000250	G-X-G motif; other site
447217000251	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
447217000252	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217000253	octamerization interface [polypeptide binding]; other site
447217000254	diferric-oxygen binding site [ion binding]; other site
447217000255	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
447217000256	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
447217000257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000258	FeS/SAM binding site; other site
447217000259	TRAM domain; Region: TRAM; cl01282
447217000260	Protein of unknown function (DUF520); Region: DUF520; cl00723
447217000261	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
447217000262	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217000263	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
447217000264	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
447217000265	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000266	Family description; Region: UvrD_C_2; cl15862
447217000267	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
447217000268	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
447217000269	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
447217000270	active site
447217000271	purine riboside binding site [chemical binding]; other site
447217000272	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
447217000273	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
447217000274	DNA binding site [nucleotide binding]
447217000275	active site
447217000276	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
447217000277	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
447217000278	ligand binding site; other site
447217000279	oligomer interface; other site
447217000280	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
447217000281	dimer interface [polypeptide binding]; other site
447217000282	N-terminal domain interface [polypeptide binding]; other site
447217000283	sulfate 1 binding site; other site
447217000284	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000286	active site
447217000287	phosphorylation site [posttranslational modification]
447217000288	intermolecular recognition site; other site
447217000289	dimerization interface [polypeptide binding]; other site
447217000290	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000291	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000292	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000293	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000294	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000295	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
447217000296	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217000297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000298	active site
447217000299	phosphorylation site [posttranslational modification]
447217000300	intermolecular recognition site; other site
447217000301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000302	Walker A motif; other site
447217000303	ATP binding site [chemical binding]; other site
447217000304	Walker B motif; other site
447217000305	Helix-turn-helix domains; Region: HTH; cl00088
447217000306	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
447217000307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000308	dimer interface [polypeptide binding]; other site
447217000309	phosphorylation site [posttranslational modification]
447217000310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000311	ATP binding site [chemical binding]; other site
447217000312	Mg2+ binding site [ion binding]; other site
447217000313	G-X-G motif; other site
447217000314	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217000315	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
447217000316	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217000317	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217000318	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217000319	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
447217000320	active site
447217000321	Zn binding site [ion binding]; other site
447217000322	rod shape-determining protein MreB; Provisional; Region: PRK13927
447217000323	Cell division protein FtsA; Region: FtsA; cl11496
447217000324	rod shape-determining protein MreB; Provisional; Region: PRK13927
447217000325	Cell division protein FtsA; Region: FtsA; cl11496
447217000326	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
447217000327	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217000328	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217000329	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217000330	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
447217000331	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217000332	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217000333	active site
447217000334	ATP binding site [chemical binding]; other site
447217000335	substrate binding site [chemical binding]; other site
447217000336	activation loop (A-loop); other site
447217000337	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
447217000338	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
447217000339	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
447217000340	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
447217000341	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
447217000342	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
447217000343	putative active site [active]
447217000344	catalytic residue [active]
447217000345	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
447217000346	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
447217000347	5S rRNA interface [nucleotide binding]; other site
447217000348	CTC domain interface [polypeptide binding]; other site
447217000349	L16 interface [polypeptide binding]; other site
447217000350	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
447217000351	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
447217000352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217000353	active site
447217000354	SpoVG; Region: SpoVG; cl00915
447217000355	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
447217000356	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217000357	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
447217000358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217000359	active site
447217000360	PilZ domain; Region: PilZ; cl01260
447217000361	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
447217000362	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217000363	phosphopeptide binding site; other site
447217000364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217000365	metal binding site [ion binding]; metal-binding site
447217000366	active site
447217000367	I-site; other site
447217000368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217000369	putative substrate translocation pore; other site
447217000370	ADP-glucose phosphorylase; Region: PLN02643
447217000371	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
447217000372	nucleotide binding site/active site [active]
447217000373	HIT family signature motif; other site
447217000374	catalytic residue [active]
447217000375	glycogen synthase; Provisional; Region: glgA; PRK00654
447217000376	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
447217000377	ADP-binding pocket [chemical binding]; other site
447217000378	homodimer interface [polypeptide binding]; other site
447217000379	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
447217000380	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
447217000381	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000382	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
447217000383	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
447217000384	Helix-turn-helix domains; Region: HTH; cl00088
447217000385	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
447217000386	active site
447217000387	DNA polymerase IV; Validated; Region: PRK02406
447217000388	DNA binding site [nucleotide binding]
447217000389	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217000390	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
447217000391	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000393	active site
447217000394	phosphorylation site [posttranslational modification]
447217000395	intermolecular recognition site; other site
447217000396	dimerization interface [polypeptide binding]; other site
447217000397	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
447217000398	DHHA1 domain; Region: DHHA1; pfam02272
447217000399	HPr kinase/phosphorylase; Provisional; Region: PRK05428
447217000400	DRTGG domain; Region: DRTGG; cl12147
447217000401	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
447217000402	Hpr binding site; other site
447217000403	active site
447217000404	homohexamer subunit interaction site [polypeptide binding]; other site
447217000405	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
447217000406	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
447217000407	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
447217000408	active pocket/dimerization site; other site
447217000409	active site
447217000410	phosphorylation site [posttranslational modification]
447217000411	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
447217000412	active site
447217000413	phosphorylation site [posttranslational modification]
447217000414	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
447217000415	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
447217000416	dimerization domain swap beta strand [polypeptide binding]; other site
447217000417	regulatory protein interface [polypeptide binding]; other site
447217000418	active site
447217000419	regulatory phosphorylation site [posttranslational modification]; other site
447217000420	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
447217000421	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
447217000422	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
447217000423	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
447217000424	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
447217000425	S-adenosylmethionine synthetase; Validated; Region: PRK05250
447217000426	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
447217000427	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
447217000428	Helix-turn-helix domains; Region: HTH; cl00088
447217000429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000430	Adenosylhomocysteinase; Provisional; Region: PTZ00075
447217000431	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
447217000432	oligomerization interface [polypeptide binding]; other site
447217000433	active site
447217000434	NAD+ binding site [chemical binding]; other site
447217000435	Bacitracin resistance protein BacA; Region: BacA; cl00858
447217000436	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
447217000437	putative active site [active]
447217000438	putative CoA binding site [chemical binding]; other site
447217000439	nudix motif; other site
447217000440	metal binding site [ion binding]; metal-binding site
447217000441	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
447217000442	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
447217000443	Substrate binding site; other site
447217000444	Cupin domain; Region: Cupin_2; cl09118
447217000445	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
447217000446	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
447217000447	active site
447217000448	substrate binding site [chemical binding]; other site
447217000449	metal binding site [ion binding]; metal-binding site
447217000450	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
447217000451	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
447217000452	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
447217000453	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
447217000454	Domain of unknown function (DUF814); Region: DUF814; pfam05670
447217000455	SprT-like family; Region: SprT-like; pfam10263
447217000456	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
447217000457	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217000458	Surface antigen; Region: Bac_surface_Ag; cl03097
447217000459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
447217000460	Family of unknown function (DUF490); Region: DUF490; pfam04357
447217000461	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217000462	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217000463	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
447217000464	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
447217000465	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
447217000466	metal binding site [ion binding]; metal-binding site
447217000467	dimer interface [polypeptide binding]; other site
447217000468	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
447217000469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000470	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
447217000471	nucleotide binding site [chemical binding]; other site
447217000472	N-acetyl-L-glutamate binding site [chemical binding]; other site
447217000473	Sulfatase; Region: Sulfatase; cl10460
447217000474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217000475	dimer interface [polypeptide binding]; other site
447217000476	phosphorylation site [posttranslational modification]
447217000477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000478	ATP binding site [chemical binding]; other site
447217000479	Mg2+ binding site [ion binding]; other site
447217000480	G-X-G motif; other site
447217000481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000482	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
447217000483	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
447217000484	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
447217000485	putative active site [active]
447217000486	dimerization interface [polypeptide binding]; other site
447217000487	putative tRNAtyr binding site [nucleotide binding]; other site
447217000488	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
447217000489	nucleotide binding site/active site [active]
447217000490	HIT family signature motif; other site
447217000491	catalytic residue [active]
447217000492	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
447217000493	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
447217000494	homotrimer interaction site [polypeptide binding]; other site
447217000495	active site
447217000496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000497	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
447217000498	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
447217000499	hinge; other site
447217000500	active site
447217000501	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
447217000502	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
447217000503	NAD(P) binding site [chemical binding]; other site
447217000504	shikimate binding site; other site
447217000505	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
447217000506	Tetramer interface [polypeptide binding]; other site
447217000507	active site
447217000508	FMN-binding site [chemical binding]; other site
447217000509	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000510	shikimate kinase; Reviewed; Region: aroK; PRK00131
447217000511	active site
447217000512	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
447217000513	dimer interface [polypeptide binding]; other site
447217000514	active site
447217000515	metal binding site [ion binding]; metal-binding site
447217000516	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
447217000517	active site
447217000518	trimer interface [polypeptide binding]; other site
447217000519	dimer interface [polypeptide binding]; other site
447217000520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217000521	active site
447217000522	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217000523	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
447217000524	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
447217000525	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
447217000526	heme binding site [chemical binding]; other site
447217000527	ferroxidase pore; other site
447217000528	ferroxidase diiron center [ion binding]; other site
447217000529	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
447217000530	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217000531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217000532	RNA binding surface [nucleotide binding]; other site
447217000533	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217000534	active site
447217000535	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
447217000536	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
447217000537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000538	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
447217000539	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
447217000540	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
447217000541	HflX GTPase family; Region: HflX; cd01878
447217000542	G1 box; other site
447217000543	GTP/Mg2+ binding site [chemical binding]; other site
447217000544	Switch I region; other site
447217000545	G2 box; other site
447217000546	G3 box; other site
447217000547	Switch II region; other site
447217000548	G4 box; other site
447217000549	benzoate transport; Region: 2A0115; TIGR00895
447217000550	putative sialic acid transporter; Region: 2A0112; TIGR00891
447217000551	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
447217000552	active site
447217000553	catalytic site [active]
447217000554	substrate binding site [chemical binding]; other site
447217000555	Peptidase family M48; Region: Peptidase_M48; cl12018
447217000556	gamma-glutamyl kinase; Provisional; Region: PRK05429
447217000557	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
447217000558	nucleotide binding site [chemical binding]; other site
447217000559	homotetrameric interface [polypeptide binding]; other site
447217000560	putative phosphate binding site [ion binding]; other site
447217000561	putative allosteric binding site; other site
447217000562	PUA domain; Region: PUA; cl00607
447217000563	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
447217000564	putative catalytic cysteine [active]
447217000565	Oligomerisation domain; Region: Oligomerisation; cl00519
447217000566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000567	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
447217000568	EamA-like transporter family; Region: EamA; cl01037
447217000569	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217000570	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217000571	active site
447217000572	ATP binding site [chemical binding]; other site
447217000573	substrate binding site [chemical binding]; other site
447217000574	activation loop (A-loop); other site
447217000575	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
447217000576	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217000577	dimer interface [polypeptide binding]; other site
447217000578	PYR/PP interface [polypeptide binding]; other site
447217000579	TPP binding site [chemical binding]; other site
447217000580	substrate binding site [chemical binding]; other site
447217000581	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
447217000582	Domain of unknown function; Region: EKR; cl11037
447217000583	4Fe-4S binding domain; Region: Fer4; cl02805
447217000584	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
447217000585	TPP-binding site [chemical binding]; other site
447217000586	dimer interface [polypeptide binding]; other site
447217000587	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217000588	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217000589	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
447217000590	putative NAD(P) binding site [chemical binding]; other site
447217000591	active site
447217000592	putative substrate binding site [chemical binding]; other site
447217000593	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
447217000594	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217000595	putative catalytic site [active]
447217000596	putative phosphate binding site [ion binding]; other site
447217000597	putative metal binding site [ion binding]; other site
447217000598	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217000599	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217000600	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217000601	DsrE/DsrF-like family; Region: DrsE; cl00672
447217000602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217000603	Helix-turn-helix domains; Region: HTH; cl00088
447217000604	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217000605	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217000606	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217000607	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217000608	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217000609	Putative zinc-finger; Region: zf-HC2; cl15806
447217000610	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
447217000611	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217000612	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
447217000613	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
447217000614	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
447217000615	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
447217000616	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
447217000617	active site
447217000618	catalytic residues [active]
447217000619	Sulfatase; Region: Sulfatase; cl10460
447217000620	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
447217000621	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
447217000622	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217000623	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
447217000624	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217000625	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
447217000626	TfoX N-terminal domain; Region: TfoX_N; cl01167
447217000627	coproporphyrinogen III oxidase; Validated; Region: PRK05628
447217000628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217000629	FeS/SAM binding site; other site
447217000630	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217000631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000632	active site
447217000633	phosphorylation site [posttranslational modification]
447217000634	intermolecular recognition site; other site
447217000635	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
447217000636	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217000638	S-adenosylmethionine binding site [chemical binding]; other site
447217000639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
447217000640	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
447217000641	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217000642	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
447217000643	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217000644	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217000645	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217000646	DNA-binding site [nucleotide binding]; DNA binding site
447217000647	RNA-binding motif; other site
447217000648	hypothetical protein; Validated; Region: PRK07586
447217000649	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
447217000650	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
447217000651	FMN binding site [chemical binding]; other site
447217000652	substrate binding site [chemical binding]; other site
447217000653	putative catalytic residue [active]
447217000654	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217000655	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217000656	putative acyl-acceptor binding pocket; other site
447217000657	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
447217000658	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000659	dimer interface [polypeptide binding]; other site
447217000660	phosphorylation site [posttranslational modification]
447217000661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000662	ATP binding site [chemical binding]; other site
447217000663	Mg2+ binding site [ion binding]; other site
447217000664	G-X-G motif; other site
447217000665	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
447217000666	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217000667	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
447217000668	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
447217000669	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217000670	carboxyltransferase (CT) interaction site; other site
447217000671	biotinylation site [posttranslational modification]; other site
447217000672	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
447217000673	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
447217000674	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217000675	HSP70 interaction site [polypeptide binding]; other site
447217000676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217000677	binding surface
447217000678	TPR motif; other site
447217000679	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
447217000680	Fumarase C-terminus; Region: Fumerase_C; cl00795
447217000681	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217000682	active site
447217000683	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217000684	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217000685	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217000686	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217000687	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217000688	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
447217000689	elongation factor Ts; Reviewed; Region: tsf; PRK12332
447217000690	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
447217000691	Elongation factor TS; Region: EF_TS; pfam00889
447217000692	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
447217000693	rRNA interaction site [nucleotide binding]; other site
447217000694	S8 interaction site; other site
447217000695	putative laminin-1 binding site; other site
447217000696	Competence protein CoiA-like family; Region: CoiA; cl11541
447217000697	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
447217000698	catalytic triad [active]
447217000699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217000700	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
447217000701	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
447217000702	DNA binding site [nucleotide binding]
447217000703	catalytic residue [active]
447217000704	H2TH interface [polypeptide binding]; other site
447217000705	putative catalytic residues [active]
447217000706	turnover-facilitating residue; other site
447217000707	intercalation triad [nucleotide binding]; other site
447217000708	8OG recognition residue [nucleotide binding]; other site
447217000709	putative reading head residues; other site
447217000710	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217000711	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217000712	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
447217000713	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217000714	active site
447217000715	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
447217000716	active site
447217000717	NTP binding site [chemical binding]; other site
447217000718	metal binding triad [ion binding]; metal-binding site
447217000719	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
447217000720	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
447217000721	putative nucleotide binding site [chemical binding]; other site
447217000722	uridine monophosphate binding site [chemical binding]; other site
447217000723	homohexameric interface [polypeptide binding]; other site
447217000724	ribosome recycling factor; Reviewed; Region: frr; PRK00083
447217000725	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
447217000726	hinge region; other site
447217000727	NAD synthetase; Provisional; Region: PRK13981
447217000728	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
447217000729	multimer interface [polypeptide binding]; other site
447217000730	active site
447217000731	catalytic triad [active]
447217000732	protein interface 1 [polypeptide binding]; other site
447217000733	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
447217000734	homodimer interface [polypeptide binding]; other site
447217000735	NAD binding pocket [chemical binding]; other site
447217000736	ATP binding pocket [chemical binding]; other site
447217000737	Mg binding site [ion binding]; other site
447217000738	active-site loop [active]
447217000739	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217000740	metal binding site [ion binding]; metal-binding site
447217000741	active site
447217000742	I-site; other site
447217000743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000744	DNA binding residues [nucleotide binding]
447217000745	transketolase; Reviewed; Region: PRK05899
447217000746	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
447217000747	TPP-binding site [chemical binding]; other site
447217000748	dimer interface [polypeptide binding]; other site
447217000749	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
447217000750	PYR/PP interface [polypeptide binding]; other site
447217000751	dimer interface [polypeptide binding]; other site
447217000752	TPP binding site [chemical binding]; other site
447217000753	Ycf46; Provisional; Region: ycf46; CHL00195
447217000754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000755	ATP binding site [chemical binding]; other site
447217000756	Walker A motif; other site
447217000757	Walker B motif; other site
447217000758	arginine finger; other site
447217000759	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
447217000760	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
447217000761	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
447217000762	active site
447217000763	catalytic site [active]
447217000764	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
447217000765	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
447217000766	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217000767	active site
447217000768	HIGH motif; other site
447217000769	nucleotide binding site [chemical binding]; other site
447217000770	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217000771	active site
447217000772	KMSKS motif; other site
447217000773	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
447217000774	active site
447217000775	dinuclear metal binding site [ion binding]; other site
447217000776	dimerization interface [polypeptide binding]; other site
447217000777	CHASE domain; Region: CHASE; cl01369
447217000778	sensor protein ZraS; Provisional; Region: PRK10364
447217000779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000780	ATP binding site [chemical binding]; other site
447217000781	Mg2+ binding site [ion binding]; other site
447217000782	G-X-G motif; other site
447217000783	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000785	active site
447217000786	phosphorylation site [posttranslational modification]
447217000787	intermolecular recognition site; other site
447217000788	dimerization interface [polypeptide binding]; other site
447217000789	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000790	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000791	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217000792	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217000793	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217000794	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
447217000795	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
447217000796	FAD binding pocket [chemical binding]; other site
447217000797	FAD binding motif [chemical binding]; other site
447217000798	phosphate binding motif [ion binding]; other site
447217000799	beta-alpha-beta structure motif; other site
447217000800	NAD binding pocket [chemical binding]; other site
447217000801	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217000802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217000803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000804	dimer interface [polypeptide binding]; other site
447217000805	phosphorylation site [posttranslational modification]
447217000806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000807	ATP binding site [chemical binding]; other site
447217000808	Mg2+ binding site [ion binding]; other site
447217000809	G-X-G motif; other site
447217000810	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217000811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000812	active site
447217000813	phosphorylation site [posttranslational modification]
447217000814	intermolecular recognition site; other site
447217000815	dimerization interface [polypeptide binding]; other site
447217000816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000817	ATP binding site [chemical binding]; other site
447217000818	Walker B motif; other site
447217000819	arginine finger; other site
447217000820	Helix-turn-helix domains; Region: HTH; cl00088
447217000821	Protein of unknown function (DUF456); Region: DUF456; cl01069
447217000822	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
447217000823	Ligand binding site; other site
447217000824	metal-binding site
447217000825	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
447217000826	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
447217000827	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217000828	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
447217000829	active site 1 [active]
447217000830	dimer interface [polypeptide binding]; other site
447217000831	hexamer interface [polypeptide binding]; other site
447217000832	active site 2 [active]
447217000833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217000834	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
447217000835	Helix-turn-helix domains; Region: HTH; cl00088
447217000836	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
447217000837	dimerization interface [polypeptide binding]; other site
447217000838	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217000839	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
447217000840	dimer interface [polypeptide binding]; other site
447217000841	decamer (pentamer of dimers) interface [polypeptide binding]; other site
447217000842	catalytic triad [active]
447217000843	peroxidatic and resolving cysteines [active]
447217000844	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
447217000845	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
447217000846	Predicted ATPase [General function prediction only]; Region: COG3899
447217000847	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000848	DNA binding residues [nucleotide binding]
447217000849	dimerization interface [polypeptide binding]; other site
447217000850	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217000851	DNA binding residues [nucleotide binding]
447217000852	dimerization interface [polypeptide binding]; other site
447217000853	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
447217000854	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
447217000855	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217000856	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
447217000857	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217000858	Bacterial Ig-like domain; Region: Big_5; cl01012
447217000859	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217000860	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217000861	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217000862	Zn binding site [ion binding]; other site
447217000863	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
447217000864	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
447217000865	SelR domain; Region: SelR; pfam01641
447217000866	Activator of aromatic catabolism; Region: XylR_N; pfam06505
447217000867	Heme NO binding; Region: HNOB; cl15268
447217000868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000869	Walker B motif; other site
447217000870	arginine finger; other site
447217000871	Helix-turn-helix domains; Region: HTH; cl00088
447217000872	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
447217000873	eyelet of channel; other site
447217000874	trimer interface [polypeptide binding]; other site
447217000875	Domain of unknown function DUF59; Region: DUF59; cl00941
447217000876	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
447217000877	reductive dehalogenase; Region: RDH; TIGR02486
447217000878	reductive dehalogenase; Region: RDH; TIGR02486
447217000879	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
447217000880	putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315
447217000881	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
447217000882	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
447217000883	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
447217000884	N-terminal plug; other site
447217000885	ligand-binding site [chemical binding]; other site
447217000886	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217000887	Activator of aromatic catabolism; Region: XylR_N; pfam06505
447217000888	Heme NO binding; Region: HNOB; cl15268
447217000889	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217000890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000891	Walker A motif; other site
447217000892	ATP binding site [chemical binding]; other site
447217000893	Walker B motif; other site
447217000894	arginine finger; other site
447217000895	Helix-turn-helix domains; Region: HTH; cl00088
447217000896	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
447217000897	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
447217000898	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217000899	catalytic residues [active]
447217000900	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
447217000901	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217000902	dimer interface [polypeptide binding]; other site
447217000903	putative CheW interface [polypeptide binding]; other site
447217000904	UbiA prenyltransferase family; Region: UbiA; cl00337
447217000905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217000907	dimerization interface [polypeptide binding]; other site
447217000908	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
447217000909	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
447217000910	intracellular protease, PfpI family; Region: PfpI; TIGR01382
447217000911	conserved cys residue [active]
447217000912	Helix-turn-helix domains; Region: HTH; cl00088
447217000913	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217000914	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217000915	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
447217000916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217000917	Helix-turn-helix domains; Region: HTH; cl00088
447217000918	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
447217000919	putative dimerization interface [polypeptide binding]; other site
447217000920	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217000921	CheB methylesterase; Region: CheB_methylest; pfam01339
447217000922	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217000923	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
447217000924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000925	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
447217000926	PAS domain; Region: PAS_10; pfam13596
447217000927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217000928	dimer interface [polypeptide binding]; other site
447217000929	phosphorylation site [posttranslational modification]
447217000930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000931	ATP binding site [chemical binding]; other site
447217000932	Mg2+ binding site [ion binding]; other site
447217000933	G-X-G motif; other site
447217000934	Response regulator receiver domain; Region: Response_reg; pfam00072
447217000935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217000936	active site
447217000937	phosphorylation site [posttranslational modification]
447217000938	intermolecular recognition site; other site
447217000939	dimerization interface [polypeptide binding]; other site
447217000940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217000941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217000942	ATP binding site [chemical binding]; other site
447217000943	Mg2+ binding site [ion binding]; other site
447217000944	G-X-G motif; other site
447217000945	Fatty acid desaturase; Region: FA_desaturase; pfam00487
447217000946	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
447217000947	putative di-iron ligands [ion binding]; other site
447217000948	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
447217000949	Protein of unknown function (DUF330); Region: DUF330; cl01135
447217000950	mce related protein; Region: MCE; pfam02470
447217000951	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
447217000952	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217000953	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217000954	Walker A/P-loop; other site
447217000955	ATP binding site [chemical binding]; other site
447217000956	Q-loop/lid; other site
447217000957	ABC transporter signature motif; other site
447217000958	Walker B; other site
447217000959	D-loop; other site
447217000960	H-loop/switch region; other site
447217000961	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
447217000962	Permease; Region: Permease; cl00510
447217000963	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
447217000964	GAF domain; Region: GAF_2; pfam13185
447217000965	Propionate catabolism activator; Region: PrpR_N; pfam06506
447217000966	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217000967	PAS domain; Region: PAS_10; pfam13596
447217000968	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
447217000969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217000970	Walker A motif; other site
447217000971	ATP binding site [chemical binding]; other site
447217000972	Walker B motif; other site
447217000973	arginine finger; other site
447217000974	Helix-turn-helix domains; Region: HTH; cl00088
447217000975	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
447217000976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217000977	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217000978	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
447217000979	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217000980	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217000981	substrate binding site [chemical binding]; other site
447217000982	oxyanion hole (OAH) forming residues; other site
447217000983	trimer interface [polypeptide binding]; other site
447217000984	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
447217000985	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217000986	dimer interface [polypeptide binding]; other site
447217000987	active site
447217000988	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217000989	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217000990	active site
447217000991	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
447217000992	Moco binding site; other site
447217000993	metal coordination site [ion binding]; other site
447217000994	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217000995	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217000996	ATP phosphoribosyltransferase; Region: HisG; cl15266
447217000997	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
447217000998	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
447217000999	hinge; other site
447217001000	active site
447217001001	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
447217001002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001003	peptide chain release factor 1; Validated; Region: prfA; PRK00591
447217001004	RF-1 domain; Region: RF-1; cl02875
447217001005	RF-1 domain; Region: RF-1; cl02875
447217001006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001007	PAS domain; Region: PAS_9; pfam13426
447217001008	putative active site [active]
447217001009	heme pocket [chemical binding]; other site
447217001010	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001011	dimer interface [polypeptide binding]; other site
447217001012	phosphorylation site [posttranslational modification]
447217001013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001014	ATP binding site [chemical binding]; other site
447217001015	Mg2+ binding site [ion binding]; other site
447217001016	G-X-G motif; other site
447217001017	Predicted transcriptional regulators [Transcription]; Region: COG1510
447217001018	UbiA prenyltransferase family; Region: UbiA; cl00337
447217001019	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217001020	active site
447217001021	NMT1-like family; Region: NMT1_2; cl15260
447217001022	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
447217001023	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
447217001024	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
447217001025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217001026	FeS/SAM binding site; other site
447217001027	aromatic acid decarboxylase; Validated; Region: PRK05920
447217001028	Flavoprotein; Region: Flavoprotein; cl08021
447217001029	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
447217001030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217001031	S-adenosylmethionine binding site [chemical binding]; other site
447217001032	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
447217001033	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217001034	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217001035	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
447217001036	substrate binding pocket [chemical binding]; other site
447217001037	chain length determination region; other site
447217001038	substrate-Mg2+ binding site; other site
447217001039	catalytic residues [active]
447217001040	aspartate-rich region 1; other site
447217001041	active site lid residues [active]
447217001042	aspartate-rich region 2; other site
447217001043	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
447217001044	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
447217001045	dimerization interface 3.5A [polypeptide binding]; other site
447217001046	active site
447217001047	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
447217001048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001049	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
447217001050	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217001051	octamerization interface [polypeptide binding]; other site
447217001052	diferric-oxygen binding site [ion binding]; other site
447217001053	Late embryogenesis abundant protein; Region: LEA_2; cl12118
447217001054	Late embryogenesis abundant protein; Region: LEA_2; cl12118
447217001055	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
447217001056	Clp amino terminal domain; Region: Clp_N; pfam02861
447217001057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001058	Walker A motif; other site
447217001059	ATP binding site [chemical binding]; other site
447217001060	Walker B motif; other site
447217001061	arginine finger; other site
447217001062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001063	Walker A motif; other site
447217001064	ATP binding site [chemical binding]; other site
447217001065	Walker B motif; other site
447217001066	arginine finger; other site
447217001067	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217001068	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217001069	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217001070	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217001071	protein binding site [polypeptide binding]; other site
447217001072	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217001073	protein binding site [polypeptide binding]; other site
447217001074	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
447217001075	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
447217001076	malonyl-CoA binding site [chemical binding]; other site
447217001077	dimer interface [polypeptide binding]; other site
447217001078	active site
447217001079	product binding site; other site
447217001080	Phosphopantetheine attachment site; Region: PP-binding; cl09936
447217001081	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
447217001082	AMP-binding enzyme; Region: AMP-binding; cl15778
447217001083	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
447217001084	TolB amino-terminal domain; Region: TolB_N; cl00639
447217001085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
447217001086	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
447217001087	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
447217001088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001089	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
447217001090	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
447217001091	active site
447217001092	Zn binding site [ion binding]; other site
447217001093	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
447217001094	FAD binding pocket [chemical binding]; other site
447217001095	FAD binding motif [chemical binding]; other site
447217001096	phosphate binding motif [ion binding]; other site
447217001097	beta-alpha-beta structure motif; other site
447217001098	NAD(p) ribose binding residues [chemical binding]; other site
447217001099	NAD binding pocket [chemical binding]; other site
447217001100	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
447217001101	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
447217001102	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
447217001103	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217001104	Cupin domain; Region: Cupin_2; cl09118
447217001105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001106	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
447217001107	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001108	Walker A/P-loop; other site
447217001109	ATP binding site [chemical binding]; other site
447217001110	Q-loop/lid; other site
447217001111	ABC transporter signature motif; other site
447217001112	Walker B; other site
447217001113	D-loop; other site
447217001114	H-loop/switch region; other site
447217001115	ParB-like nuclease domain; Region: ParBc; cl02129
447217001116	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
447217001117	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217001118	dimer interface [polypeptide binding]; other site
447217001119	active site
447217001120	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
447217001121	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217001122	substrate binding site [chemical binding]; other site
447217001123	oxyanion hole (OAH) forming residues; other site
447217001124	trimer interface [polypeptide binding]; other site
447217001125	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001126	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001127	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217001128	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217001129	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217001130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001131	dimer interface [polypeptide binding]; other site
447217001132	phosphorylation site [posttranslational modification]
447217001133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001134	ATP binding site [chemical binding]; other site
447217001135	G-X-G motif; other site
447217001136	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217001137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001138	active site
447217001139	phosphorylation site [posttranslational modification]
447217001140	intermolecular recognition site; other site
447217001141	dimerization interface [polypeptide binding]; other site
447217001142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217001143	DNA binding site [nucleotide binding]
447217001144	selenocysteine synthase; Provisional; Region: PRK04311
447217001145	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
447217001146	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217001147	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
447217001148	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
447217001149	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217001150	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
447217001151	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217001152	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
447217001153	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217001154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
447217001155	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001157	active site
447217001158	phosphorylation site [posttranslational modification]
447217001159	intermolecular recognition site; other site
447217001160	dimerization interface [polypeptide binding]; other site
447217001161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001162	Walker A motif; other site
447217001163	ATP binding site [chemical binding]; other site
447217001164	Walker B motif; other site
447217001165	arginine finger; other site
447217001166	Helix-turn-helix domains; Region: HTH; cl00088
447217001167	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001168	PAS domain; Region: PAS_9; pfam13426
447217001169	putative active site [active]
447217001170	heme pocket [chemical binding]; other site
447217001171	GAF domain; Region: GAF; cl15785
447217001172	GAF domain; Region: GAF_2; pfam13185
447217001173	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
447217001174	GAF domain; Region: GAF; cl15785
447217001175	GAF domain; Region: GAF; cl15785
447217001176	GAF domain; Region: GAF; cl15785
447217001177	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217001178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001179	dimer interface [polypeptide binding]; other site
447217001180	phosphorylation site [posttranslational modification]
447217001181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001182	ATP binding site [chemical binding]; other site
447217001183	G-X-G motif; other site
447217001184	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
447217001185	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
447217001186	G1 box; other site
447217001187	putative GEF interaction site [polypeptide binding]; other site
447217001188	GTP/Mg2+ binding site [chemical binding]; other site
447217001189	Switch I region; other site
447217001190	G2 box; other site
447217001191	G3 box; other site
447217001192	Switch II region; other site
447217001193	G4 box; other site
447217001194	G5 box; other site
447217001195	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
447217001196	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
447217001197	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
447217001198	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
447217001199	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
447217001200	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
447217001201	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
447217001202	dimerization interface [polypeptide binding]; other site
447217001203	domain crossover interface; other site
447217001204	redox-dependent activation switch; other site
447217001205	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
447217001206	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217001207	putative NAD(P) binding site [chemical binding]; other site
447217001208	active site
447217001209	putative substrate binding site [chemical binding]; other site
447217001210	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217001211	putative acyl-acceptor binding pocket; other site
447217001212	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217001213	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
447217001214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001215	binding surface
447217001216	TPR motif; other site
447217001217	TPR repeat; Region: TPR_11; pfam13414
447217001218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001219	binding surface
447217001220	TPR motif; other site
447217001221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001222	TPR motif; other site
447217001223	binding surface
447217001224	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
447217001225	Helix-turn-helix domains; Region: HTH; cl00088
447217001226	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217001227	GAF domain; Region: GAF; cl15785
447217001228	GAF domain; Region: GAF; cl15785
447217001229	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217001230	phosphopeptide binding site; other site
447217001231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217001232	metal binding site [ion binding]; metal-binding site
447217001233	active site
447217001234	I-site; other site
447217001235	Protein of unknown function DUF72; Region: DUF72; cl00777
447217001236	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217001237	putative catalytic site [active]
447217001238	putative metal binding site [ion binding]; other site
447217001239	putative phosphate binding site [ion binding]; other site
447217001240	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
447217001241	active site
447217001242	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
447217001243	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217001244	active site
447217001245	RHS protein; Region: RHS; pfam03527
447217001246	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217001247	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001248	Walker A/P-loop; other site
447217001249	ATP binding site [chemical binding]; other site
447217001250	Q-loop/lid; other site
447217001251	exonuclease subunit SbcC; Provisional; Region: PRK10246
447217001252	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001253	Q-loop/lid; other site
447217001254	ABC transporter signature motif; other site
447217001255	Walker B; other site
447217001256	D-loop; other site
447217001257	H-loop/switch region; other site
447217001258	exonuclease subunit SbcD; Provisional; Region: PRK10966
447217001259	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
447217001260	active site
447217001261	metal binding site [ion binding]; metal-binding site
447217001262	DNA binding site [nucleotide binding]
447217001263	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
447217001264	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217001265	active site residue [active]
447217001266	Chromate transporter; Region: Chromate_transp; pfam02417
447217001267	Chromate transporter; Region: Chromate_transp; pfam02417
447217001268	NosL; Region: NosL; cl01769
447217001269	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217001270	FtsX-like permease family; Region: FtsX; cl15850
447217001271	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217001272	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217001273	Walker A/P-loop; other site
447217001274	ATP binding site [chemical binding]; other site
447217001275	Q-loop/lid; other site
447217001276	ABC transporter signature motif; other site
447217001277	Walker B; other site
447217001278	D-loop; other site
447217001279	H-loop/switch region; other site
447217001280	Cation efflux family; Region: Cation_efflux; cl00316
447217001281	Cation efflux family; Region: Cation_efflux; cl00316
447217001282	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217001283	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
447217001284	Helix-turn-helix domains; Region: HTH; cl00088
447217001285	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
447217001286	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
447217001287	active site
447217001288	homotetramer interface [polypeptide binding]; other site
447217001289	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217001290	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
447217001291	dinuclear metal binding motif [ion binding]; other site
447217001292	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217001293	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217001294	active site
447217001295	catalytic tetrad [active]
447217001296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001297	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
447217001298	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
447217001299	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001300	Walker A/P-loop; other site
447217001301	ATP binding site [chemical binding]; other site
447217001302	Q-loop/lid; other site
447217001303	ABC transporter signature motif; other site
447217001304	Walker B; other site
447217001305	D-loop; other site
447217001306	H-loop/switch region; other site
447217001307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001308	dimerization interface [polypeptide binding]; other site
447217001309	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
447217001310	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
447217001311	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
447217001312	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217001313	substrate binding pocket [chemical binding]; other site
447217001314	membrane-bound complex binding site; other site
447217001315	hinge residues; other site
447217001316	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217001317	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217001318	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217001319	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217001320	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217001321	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
447217001322	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
447217001323	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217001324	carboxyltransferase (CT) interaction site; other site
447217001325	biotinylation site [posttranslational modification]; other site
447217001326	RNA polymerase sigma factor; Provisional; Region: PRK11922
447217001327	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217001328	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217001329	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
447217001330	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
447217001331	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217001332	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
447217001333	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217001334	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
447217001335	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
447217001336	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
447217001337	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217001338	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217001339	homodimer interface [polypeptide binding]; other site
447217001340	catalytic residue [active]
447217001341	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001342	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
447217001343	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
447217001344	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
447217001345	dimerization interface [polypeptide binding]; other site
447217001346	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
447217001347	ATP binding site [chemical binding]; other site
447217001348	Hydrogenase formation hypA family; Region: HypD; cl12072
447217001349	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
447217001350	HupF/HypC family; Region: HupF_HypC; cl00394
447217001351	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
447217001352	Acylphosphatase; Region: Acylphosphatase; cl00551
447217001353	HypF finger; Region: zf-HYPF; pfam07503
447217001354	HypF finger; Region: zf-HYPF; pfam07503
447217001355	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
447217001356	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
447217001357	nickel binding site [ion binding]; other site
447217001358	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
447217001359	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217001360	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
447217001361	hydrogenase 2 small subunit; Provisional; Region: PRK10468
447217001362	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
447217001363	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
447217001364	Helix-turn-helix domains; Region: HTH; cl00088
447217001365	Nudix hydrolase homolog; Region: PLN02791
447217001366	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
447217001367	N-terminal plug; other site
447217001368	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
447217001369	ligand-binding site [chemical binding]; other site
447217001370	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
447217001371	TPR repeat; Region: TPR_11; pfam13414
447217001372	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217001373	MgtC family; Region: MgtC; pfam02308
447217001374	Predicted membrane protein [Function unknown]; Region: COG2119
447217001375	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
447217001376	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
447217001377	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
447217001378	YwiC-like protein; Region: YwiC; pfam14256
447217001379	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
447217001380	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217001381	octamerization interface [polypeptide binding]; other site
447217001382	diferric-oxygen binding site [ion binding]; other site
447217001383	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
447217001384	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
447217001385	Walker A/P-loop; other site
447217001386	ATP binding site [chemical binding]; other site
447217001387	Q-loop/lid; other site
447217001388	ABC transporter signature motif; other site
447217001389	Walker B; other site
447217001390	D-loop; other site
447217001391	H-loop/switch region; other site
447217001392	cobalt transport protein CbiM; Provisional; Region: PRK07331
447217001393	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
447217001394	nickel responsive regulator; Provisional; Region: PRK04460
447217001395	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
447217001396	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
447217001397	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217001398	substrate binding site [chemical binding]; other site
447217001399	ATP binding site [chemical binding]; other site
447217001400	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217001401	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217001402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001403	dimer interface [polypeptide binding]; other site
447217001404	phosphorylation site [posttranslational modification]
447217001405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001406	ATP binding site [chemical binding]; other site
447217001407	G-X-G motif; other site
447217001408	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001410	active site
447217001411	phosphorylation site [posttranslational modification]
447217001412	intermolecular recognition site; other site
447217001413	dimerization interface [polypeptide binding]; other site
447217001414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001415	Walker A motif; other site
447217001416	ATP binding site [chemical binding]; other site
447217001417	Walker B motif; other site
447217001418	arginine finger; other site
447217001419	Helix-turn-helix domains; Region: HTH; cl00088
447217001420	Vitamin K epoxide reductase family; Region: VKOR; cl01729
447217001421	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217001422	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217001423	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217001424	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217001425	putative active site [active]
447217001426	heme pocket [chemical binding]; other site
447217001427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001428	dimer interface [polypeptide binding]; other site
447217001429	phosphorylation site [posttranslational modification]
447217001430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001431	ATP binding site [chemical binding]; other site
447217001432	Mg2+ binding site [ion binding]; other site
447217001433	G-X-G motif; other site
447217001434	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
447217001435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001436	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
447217001437	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217001438	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
447217001439	dimerization interface [polypeptide binding]; other site
447217001440	active site
447217001441	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
447217001442	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
447217001443	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217001444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
447217001445	phosphorylation site [posttranslational modification]
447217001446	intermolecular recognition site; other site
447217001447	Integral membrane protein TerC family; Region: TerC; cl10468
447217001448	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
447217001449	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
447217001450	Protein export membrane protein; Region: SecD_SecF; cl14618
447217001451	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
447217001452	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217001453	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217001454	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217001455	Helix-turn-helix domains; Region: HTH; cl00088
447217001456	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
447217001457	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
447217001458	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217001459	Ca binding site [ion binding]; other site
447217001460	active site
447217001461	catalytic site [active]
447217001462	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217001463	Calicivirus coat protein C-terminal; Region: Calici_coat_C; pfam08435
447217001464	Protein of unknown function (DUF454); Region: DUF454; cl01063
447217001465	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
447217001466	Helix-turn-helix domains; Region: HTH; cl00088
447217001467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001468	dimerization interface [polypeptide binding]; other site
447217001469	aspartate racemase; Region: asp_race; TIGR00035
447217001470	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
447217001471	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217001472	putative dimer interface [polypeptide binding]; other site
447217001473	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217001474	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217001475	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217001476	aspartate aminotransferase; Provisional; Region: PRK06836
447217001477	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217001478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217001479	homodimer interface [polypeptide binding]; other site
447217001480	catalytic residue [active]
447217001481	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217001482	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217001483	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217001484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001485	dimer interface [polypeptide binding]; other site
447217001486	phosphorylation site [posttranslational modification]
447217001487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001488	ATP binding site [chemical binding]; other site
447217001489	Mg2+ binding site [ion binding]; other site
447217001490	G-X-G motif; other site
447217001491	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
447217001492	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
447217001493	Walker A/P-loop; other site
447217001494	ATP binding site [chemical binding]; other site
447217001495	Q-loop/lid; other site
447217001496	ABC transporter signature motif; other site
447217001497	Walker B; other site
447217001498	D-loop; other site
447217001499	H-loop/switch region; other site
447217001500	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
447217001501	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217001502	Helix-turn-helix domains; Region: HTH; cl00088
447217001503	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
447217001504	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
447217001505	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
447217001506	DsrE/DsrF-like family; Region: DrsE; cl00672
447217001507	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217001508	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217001509	active site
447217001510	catalytic tetrad [active]
447217001511	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
447217001512	Helix-turn-helix domain; Region: HTH_18; pfam12833
447217001513	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217001514	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217001515	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217001516	Helix-turn-helix domains; Region: HTH; cl00088
447217001517	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217001518	dimerization interface [polypeptide binding]; other site
447217001519	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
447217001520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001521	NAD(P) binding site [chemical binding]; other site
447217001522	active site
447217001523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217001524	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217001525	putative substrate translocation pore; other site
447217001526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217001527	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
447217001528	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
447217001529	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
447217001530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001531	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217001532	NAD(P) binding site [chemical binding]; other site
447217001533	active site
447217001534	transcriptional regulator; Provisional; Region: PRK10632
447217001535	Helix-turn-helix domains; Region: HTH; cl00088
447217001536	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
447217001537	putative effector binding pocket; other site
447217001538	putative dimerization interface [polypeptide binding]; other site
447217001539	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217001540	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217001541	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217001542	DNA binding residues [nucleotide binding]
447217001543	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
447217001544	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
447217001545	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
447217001546	Fic family protein [Function unknown]; Region: COG3177
447217001547	Fic/DOC family; Region: Fic; cl00960
447217001548	ATP-dependent helicase HepA; Validated; Region: PRK04914
447217001549	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001550	ATP binding site [chemical binding]; other site
447217001551	putative Mg++ binding site [ion binding]; other site
447217001552	ATP-dependent helicase HepA; Validated; Region: PRK04914
447217001553	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001554	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
447217001555	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
447217001556	metal binding site [ion binding]; metal-binding site
447217001557	putative dimer interface [polypeptide binding]; other site
447217001558	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
447217001559	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217001560	active site
447217001561	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
447217001562	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
447217001563	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
447217001564	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001566	active site
447217001567	phosphorylation site [posttranslational modification]
447217001568	intermolecular recognition site; other site
447217001569	dimerization interface [polypeptide binding]; other site
447217001570	GAF domain; Region: GAF; cl15785
447217001571	GAF domain; Region: GAF_2; pfam13185
447217001572	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
447217001573	Tellurium resistance protein; Region: Tellurium_res; pfam10138
447217001574	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001576	active site
447217001577	phosphorylation site [posttranslational modification]
447217001578	intermolecular recognition site; other site
447217001579	dimerization interface [polypeptide binding]; other site
447217001580	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217001581	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
447217001582	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
447217001583	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
447217001584	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217001585	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217001586	octamerization interface [polypeptide binding]; other site
447217001587	diferric-oxygen binding site [ion binding]; other site
447217001588	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217001589	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217001590	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217001591	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217001592	dimerization interface [polypeptide binding]; other site
447217001593	sensory histidine kinase AtoS; Provisional; Region: PRK11360
447217001594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001595	ATP binding site [chemical binding]; other site
447217001596	Mg2+ binding site [ion binding]; other site
447217001597	G-X-G motif; other site
447217001598	Protein of unknown function (DUF1054); Region: DUF1054; cl11544
447217001599	WYL domain; Region: WYL; cl14852
447217001600	WYL domain; Region: WYL; cl14852
447217001601	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001603	active site
447217001604	phosphorylation site [posttranslational modification]
447217001605	intermolecular recognition site; other site
447217001606	dimerization interface [polypeptide binding]; other site
447217001607	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
447217001608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001609	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
447217001610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001611	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
447217001612	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
447217001613	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
447217001614	heterotetramer interface [polypeptide binding]; other site
447217001615	active site pocket [active]
447217001616	cleavage site
447217001617	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
447217001618	feedback inhibition sensing region; other site
447217001619	homohexameric interface [polypeptide binding]; other site
447217001620	nucleotide binding site [chemical binding]; other site
447217001621	N-acetyl-L-glutamate binding site [chemical binding]; other site
447217001622	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
447217001623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001624	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
447217001625	Bacterial Ig-like domain; Region: Big_5; cl01012
447217001626	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217001627	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
447217001628	DsbD alpha interface [polypeptide binding]; other site
447217001629	catalytic residues [active]
447217001630	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217001631	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
447217001632	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217001633	catalytic residue [active]
447217001634	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
447217001635	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
447217001636	trimerization site [polypeptide binding]; other site
447217001637	active site
447217001638	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
447217001639	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
447217001640	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
447217001641	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
447217001642	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
447217001643	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217001644	catalytic loop [active]
447217001645	iron binding site [ion binding]; other site
447217001646	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
447217001647	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217001648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001649	active site
447217001650	phosphorylation site [posttranslational modification]
447217001651	intermolecular recognition site; other site
447217001652	dimerization interface [polypeptide binding]; other site
447217001653	CheB methylesterase; Region: CheB_methylest; pfam01339
447217001654	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217001655	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217001656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001657	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217001658	putative CheA interaction surface; other site
447217001659	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217001660	putative binding surface; other site
447217001661	active site
447217001662	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217001663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001664	ATP binding site [chemical binding]; other site
447217001665	Mg2+ binding site [ion binding]; other site
447217001666	G-X-G motif; other site
447217001667	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217001668	CheD chemotactic sensory transduction; Region: CheD; cl00810
447217001669	GAF domain; Region: GAF; cl15785
447217001670	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001672	active site
447217001673	phosphorylation site [posttranslational modification]
447217001674	intermolecular recognition site; other site
447217001675	dimerization interface [polypeptide binding]; other site
447217001676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001677	active site
447217001678	phosphorylation site [posttranslational modification]
447217001679	intermolecular recognition site; other site
447217001680	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217001681	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217001682	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217001683	dimer interface [polypeptide binding]; other site
447217001684	putative CheW interface [polypeptide binding]; other site
447217001685	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217001686	putative binding surface; other site
447217001687	active site
447217001688	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
447217001689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001690	ATP binding site [chemical binding]; other site
447217001691	Mg2+ binding site [ion binding]; other site
447217001692	G-X-G motif; other site
447217001693	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217001694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001695	active site
447217001696	phosphorylation site [posttranslational modification]
447217001697	intermolecular recognition site; other site
447217001698	dimerization interface [polypeptide binding]; other site
447217001699	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217001700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001701	active site
447217001702	phosphorylation site [posttranslational modification]
447217001703	intermolecular recognition site; other site
447217001704	dimerization interface [polypeptide binding]; other site
447217001705	CheB methylesterase; Region: CheB_methylest; pfam01339
447217001706	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217001707	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001708	Response regulator receiver domain; Region: Response_reg; pfam00072
447217001709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001710	active site
447217001711	phosphorylation site [posttranslational modification]
447217001712	intermolecular recognition site; other site
447217001713	dimerization interface [polypeptide binding]; other site
447217001714	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
447217001715	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
447217001716	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
447217001717	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
447217001718	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
447217001719	PilZ domain; Region: PilZ; cl01260
447217001720	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
447217001721	active site
447217001722	catalytic motif [active]
447217001723	Zn binding site [ion binding]; other site
447217001724	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
447217001725	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
447217001726	active site
447217001727	Riboflavin kinase; Region: Flavokinase; cl03312
447217001728	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
447217001729	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217001730	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
447217001731	Walker A motif; other site
447217001732	ATP binding site [chemical binding]; other site
447217001733	Walker B motif; other site
447217001734	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
447217001735	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
447217001736	Walker A motif; other site
447217001737	ATP binding site [chemical binding]; other site
447217001738	Walker B motif; other site
447217001739	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
447217001740	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217001741	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217001742	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217001743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217001744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001745	dimer interface [polypeptide binding]; other site
447217001746	phosphorylation site [posttranslational modification]
447217001747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001748	ATP binding site [chemical binding]; other site
447217001749	Mg2+ binding site [ion binding]; other site
447217001750	G-X-G motif; other site
447217001751	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001753	active site
447217001754	phosphorylation site [posttranslational modification]
447217001755	intermolecular recognition site; other site
447217001756	dimerization interface [polypeptide binding]; other site
447217001757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001758	Walker A motif; other site
447217001759	ATP binding site [chemical binding]; other site
447217001760	Walker B motif; other site
447217001761	arginine finger; other site
447217001762	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
447217001763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217001764	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
447217001765	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001766	Walker A/P-loop; other site
447217001767	ATP binding site [chemical binding]; other site
447217001768	Q-loop/lid; other site
447217001769	ABC transporter signature motif; other site
447217001770	Walker B; other site
447217001771	D-loop; other site
447217001772	H-loop/switch region; other site
447217001773	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
447217001774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217001775	dimer interface [polypeptide binding]; other site
447217001776	phosphorylation site [posttranslational modification]
447217001777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217001778	ATP binding site [chemical binding]; other site
447217001779	Mg2+ binding site [ion binding]; other site
447217001780	G-X-G motif; other site
447217001781	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001783	active site
447217001784	phosphorylation site [posttranslational modification]
447217001785	intermolecular recognition site; other site
447217001786	dimerization interface [polypeptide binding]; other site
447217001787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001788	Walker A motif; other site
447217001789	ATP binding site [chemical binding]; other site
447217001790	Walker B motif; other site
447217001791	Helix-turn-helix domains; Region: HTH; cl00088
447217001792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217001793	non-specific DNA binding site [nucleotide binding]; other site
447217001794	salt bridge; other site
447217001795	sequence-specific DNA binding site [nucleotide binding]; other site
447217001796	Competence protein A; Region: Competence_A; pfam11104
447217001797	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
447217001798	Pilus assembly protein, PilO; Region: PilO; cl01234
447217001799	Pilus assembly protein, PilP; Region: PilP; cl01235
447217001800	AMIN domain; Region: AMIN; pfam11741
447217001801	AMIN domain; Region: AMIN; pfam11741
447217001802	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
447217001803	Secretin and TonB N terminus short domain; Region: STN; cl06624
447217001804	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217001805	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217001806	elongation factor P; Validated; Region: PRK00529
447217001807	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
447217001808	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
447217001809	RNA binding site [nucleotide binding]; other site
447217001810	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
447217001811	RNA binding site [nucleotide binding]; other site
447217001812	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
447217001813	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217001814	carboxyltransferase (CT) interaction site; other site
447217001815	biotinylation site [posttranslational modification]; other site
447217001816	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
447217001817	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217001818	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217001819	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
447217001820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001821	binding surface
447217001822	TPR motif; other site
447217001823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001824	binding surface
447217001825	TPR motif; other site
447217001826	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217001827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217001828	binding surface
447217001829	TPR motif; other site
447217001830	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
447217001831	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
447217001833	Family of unknown function (DUF490); Region: DUF490; pfam04357
447217001834	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
447217001835	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217001836	Surface antigen; Region: Bac_surface_Ag; cl03097
447217001837	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217001838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217001839	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
447217001840	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217001841	TolB amino-terminal domain; Region: TolB_N; cl00639
447217001842	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001843	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001844	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001845	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217001846	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217001847	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217001848	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217001849	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
447217001850	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
447217001851	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217001852	Walker A/P-loop; other site
447217001853	ATP binding site [chemical binding]; other site
447217001854	Q-loop/lid; other site
447217001855	ABC transporter signature motif; other site
447217001856	Walker B; other site
447217001857	D-loop; other site
447217001858	H-loop/switch region; other site
447217001859	FtsX-like permease family; Region: FtsX; cl15850
447217001860	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
447217001861	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217001862	C-terminal peptidase (prc); Region: prc; TIGR00225
447217001863	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217001864	protein binding site [polypeptide binding]; other site
447217001865	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
447217001866	Catalytic dyad [active]
447217001867	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
447217001868	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217001869	DXD motif; other site
447217001870	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217001871	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
447217001872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217001873	motif II; other site
447217001874	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
447217001875	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
447217001876	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
447217001877	P loop; other site
447217001878	GTP binding site [chemical binding]; other site
447217001879	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
447217001880	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
447217001881	Walker A/P-loop; other site
447217001882	ATP binding site [chemical binding]; other site
447217001883	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
447217001884	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
447217001885	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
447217001886	Q-loop/lid; other site
447217001887	ABC transporter signature motif; other site
447217001888	Walker B; other site
447217001889	D-loop; other site
447217001890	H-loop/switch region; other site
447217001891	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217001892	dimerization interface [polypeptide binding]; other site
447217001893	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217001894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217001895	dimer interface [polypeptide binding]; other site
447217001896	putative CheW interface [polypeptide binding]; other site
447217001897	Competence protein A; Region: Competence_A; pfam11104
447217001898	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
447217001899	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
447217001900	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
447217001901	general secretion pathway protein J; Region: gspJ; TIGR01711
447217001902	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
447217001903	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
447217001904	general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710
447217001905	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
447217001906	general secretion pathway protein F; Region: GspF; TIGR02120
447217001907	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217001908	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217001909	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217001910	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
447217001911	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
447217001912	Walker A motif; other site
447217001913	ATP binding site [chemical binding]; other site
447217001914	Walker B motif; other site
447217001915	general secretion pathway protein D; Region: type_II_gspD; TIGR02517
447217001916	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217001917	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217001918	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
447217001919	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217001920	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
447217001921	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217001922	protein binding site [polypeptide binding]; other site
447217001923	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217001924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217001925	active site
447217001926	phosphorylation site [posttranslational modification]
447217001927	intermolecular recognition site; other site
447217001928	dimerization interface [polypeptide binding]; other site
447217001929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217001930	Walker A motif; other site
447217001931	ATP binding site [chemical binding]; other site
447217001932	Walker B motif; other site
447217001933	Helix-turn-helix domains; Region: HTH; cl00088
447217001934	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
447217001935	transcription termination factor Rho; Provisional; Region: rho; PRK09376
447217001936	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
447217001937	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
447217001938	RNA binding site [nucleotide binding]; other site
447217001939	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
447217001940	multimer interface [polypeptide binding]; other site
447217001941	Walker A motif; other site
447217001942	ATP binding site [chemical binding]; other site
447217001943	Walker B motif; other site
447217001944	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
447217001945	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
447217001946	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
447217001947	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
447217001948	nucleotide binding pocket [chemical binding]; other site
447217001949	K-X-D-G motif; other site
447217001950	catalytic site [active]
447217001951	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
447217001952	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
447217001953	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
447217001954	Dimer interface [polypeptide binding]; other site
447217001955	BRCT sequence motif; other site
447217001956	Acylphosphatase; Region: Acylphosphatase; cl00551
447217001957	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
447217001958	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217001959	FeS/SAM binding site; other site
447217001960	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
447217001961	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
447217001962	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
447217001963	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217001964	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
447217001965	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
447217001966	Rrf2 family protein; Region: rrf2_super; TIGR00738
447217001967	Helix-turn-helix domains; Region: HTH; cl00088
447217001968	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217001969	IHF dimer interface [polypeptide binding]; other site
447217001970	IHF - DNA interface [nucleotide binding]; other site
447217001971	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
447217001972	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
447217001973	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
447217001974	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
447217001975	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
447217001976	FliP family; Region: FliP; cl00593
447217001977	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
447217001978	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
447217001979	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
447217001980	conserved hypothetical protein; Region: QEGLA; TIGR02421
447217001981	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
447217001982	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
447217001983	dinuclear metal binding motif [ion binding]; other site
447217001984	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
447217001985	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217001986	DNA binding residues [nucleotide binding]
447217001987	dimerization interface [polypeptide binding]; other site
447217001988	histidinol dehydrogenase; Region: hisD; TIGR00069
447217001989	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
447217001990	NAD binding site [chemical binding]; other site
447217001991	dimerization interface [polypeptide binding]; other site
447217001992	product binding site; other site
447217001993	substrate binding site [chemical binding]; other site
447217001994	zinc binding site [ion binding]; other site
447217001995	catalytic residues [active]
447217001996	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
447217001997	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
447217001998	putative active site pocket [active]
447217001999	4-fold oligomerization interface [polypeptide binding]; other site
447217002000	metal binding residues [ion binding]; metal-binding site
447217002001	3-fold/trimer interface [polypeptide binding]; other site
447217002002	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
447217002003	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
447217002004	putative active site [active]
447217002005	oxyanion strand; other site
447217002006	catalytic triad [active]
447217002007	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
447217002008	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
447217002009	catalytic residues [active]
447217002010	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
447217002011	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
447217002012	substrate binding site [chemical binding]; other site
447217002013	glutamase interaction surface [polypeptide binding]; other site
447217002014	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
447217002015	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
447217002016	GatB domain; Region: GatB_Yqey; cl11497
447217002017	DNA primase, catalytic core; Region: dnaG; TIGR01391
447217002018	CHC2 zinc finger; Region: zf-CHC2; cl15369
447217002019	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
447217002020	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
447217002021	active site
447217002022	metal binding site [ion binding]; metal-binding site
447217002023	interdomain interaction site; other site
447217002024	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
447217002025	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
447217002026	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217002027	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
447217002028	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002029	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
447217002030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217002031	DNA binding residues [nucleotide binding]
447217002032	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
447217002033	Putative zinc ribbon domain; Region: DUF164; pfam02591
447217002034	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
447217002035	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217002036	active site
447217002037	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
447217002038	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
447217002039	active site
447217002040	catalytic residues [active]
447217002041	metal binding site [ion binding]; metal-binding site
447217002042	primosome assembly protein PriA; Validated; Region: PRK05580
447217002043	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002044	ATP binding site [chemical binding]; other site
447217002045	putative Mg++ binding site [ion binding]; other site
447217002046	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217002047	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
447217002048	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217002049	recombination factor protein RarA; Reviewed; Region: PRK13342
447217002050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002051	Walker A motif; other site
447217002052	ATP binding site [chemical binding]; other site
447217002053	Walker B motif; other site
447217002054	arginine finger; other site
447217002055	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
447217002056	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
447217002057	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
447217002058	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
447217002059	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
447217002060	Walker A/P-loop; other site
447217002061	ATP binding site [chemical binding]; other site
447217002062	Q-loop/lid; other site
447217002063	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
447217002064	ABC transporter signature motif; other site
447217002065	Walker B; other site
447217002066	D-loop; other site
447217002067	H-loop/switch region; other site
447217002068	Protein phosphatase 2C; Region: PP2C; pfam00481
447217002069	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
447217002070	active site
447217002071	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217002072	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
447217002073	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
447217002074	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217002075	nucleotide binding region [chemical binding]; other site
447217002076	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
447217002077	SEC-C motif; Region: SEC-C; pfam02810
447217002078	Helix-turn-helix domains; Region: HTH; cl00088
447217002079	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217002080	active site
447217002081	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
447217002082	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
447217002083	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002084	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
447217002085	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
447217002086	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
447217002087	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
447217002088	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
447217002089	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
447217002090	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187
447217002091	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
447217002092	Integrase core domain; Region: rve; cl01316
447217002093	transposase/IS protein; Provisional; Region: PRK09183
447217002094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002095	Walker A motif; other site
447217002096	ATP binding site [chemical binding]; other site
447217002097	Walker B motif; other site
447217002098	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
447217002099	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217002101	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217002102	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002103	active site
447217002104	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
447217002105	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
447217002106	FAD binding pocket [chemical binding]; other site
447217002107	conserved FAD binding motif [chemical binding]; other site
447217002108	phosphate binding motif [ion binding]; other site
447217002109	beta-alpha-beta structure motif; other site
447217002110	NAD binding pocket [chemical binding]; other site
447217002111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217002112	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
447217002113	active site
447217002114	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217002115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217002116	active site
447217002117	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
447217002118	putative peptidoglycan binding site; other site
447217002119	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217002120	Survival protein SurE; Region: SurE; cl00448
447217002121	Helix-turn-helix domains; Region: HTH; cl00088
447217002122	GAF domain; Region: GAF_2; pfam13185
447217002123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002124	dimer interface [polypeptide binding]; other site
447217002125	phosphorylation site [posttranslational modification]
447217002126	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217002127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002128	ATP binding site [chemical binding]; other site
447217002129	Mg2+ binding site [ion binding]; other site
447217002130	G-X-G motif; other site
447217002131	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
447217002132	substrate binding site [chemical binding]; other site
447217002133	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
447217002134	putative deacylase active site [active]
447217002135	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
447217002136	4Fe-4S binding domain; Region: Fer4; cl02805
447217002137	Predicted permeases [General function prediction only]; Region: RarD; COG2962
447217002138	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217002139	Ligand Binding Site [chemical binding]; other site
447217002140	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
447217002141	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
447217002142	putative active site [active]
447217002143	putative FMN binding site [chemical binding]; other site
447217002144	putative substrate binding site [chemical binding]; other site
447217002145	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217002146	Ferritin-like domain; Region: Ferritin; pfam00210
447217002147	binuclear metal center [ion binding]; other site
447217002148	tricarballylate utilization protein B; Provisional; Region: PRK15033
447217002149	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
447217002150	Cysteine-rich domain; Region: CCG; pfam02754
447217002151	Cysteine-rich domain; Region: CCG; pfam02754
447217002152	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
447217002153	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
447217002154	active site
447217002155	substrate binding site [chemical binding]; other site
447217002156	catalytic site [active]
447217002157	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
447217002158	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217002159	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217002160	ligand binding site [chemical binding]; other site
447217002161	flexible hinge region; other site
447217002162	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217002163	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217002164	metal binding triad; other site
447217002165	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217002166	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002167	active site
447217002168	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
447217002169	Response regulator receiver domain; Region: Response_reg; pfam00072
447217002170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002171	active site
447217002172	phosphorylation site [posttranslational modification]
447217002173	intermolecular recognition site; other site
447217002174	dimerization interface [polypeptide binding]; other site
447217002175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002176	NAD(P) binding site [chemical binding]; other site
447217002177	active site
447217002178	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
447217002179	Domain of unknown function DUF21; Region: DUF21; pfam01595
447217002180	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217002181	Transporter associated domain; Region: CorC_HlyC; cl08393
447217002182	hypothetical protein; Provisional; Region: PRK07877
447217002183	Methyltransferase domain; Region: Methyltransf_31; pfam13847
447217002184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217002185	S-adenosylmethionine binding site [chemical binding]; other site
447217002186	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
447217002187	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
447217002188	TPP-binding site [chemical binding]; other site
447217002189	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
447217002190	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217002191	E3 interaction surface; other site
447217002192	lipoyl attachment site [posttranslational modification]; other site
447217002193	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
447217002194	Protein of unknown function DUF72; Region: DUF72; cl00777
447217002195	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
447217002196	active site
447217002197	DNA binding site [nucleotide binding]
447217002198	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
447217002199	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
447217002200	DNA binding site [nucleotide binding]
447217002201	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
447217002202	nucleotide binding site [chemical binding]; other site
447217002203	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002204	ATP binding site [chemical binding]; other site
447217002205	putative Mg++ binding site [ion binding]; other site
447217002206	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002207	Helicase associated domain (HA2); Region: HA2; cl04503
447217002208	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
447217002209	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
447217002210	putative dimer interface [polypeptide binding]; other site
447217002211	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
447217002212	Clp amino terminal domain; Region: Clp_N; pfam02861
447217002213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002214	Walker A motif; other site
447217002215	ATP binding site [chemical binding]; other site
447217002216	Walker B motif; other site
447217002217	arginine finger; other site
447217002218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002219	Walker A motif; other site
447217002220	ATP binding site [chemical binding]; other site
447217002221	Walker B motif; other site
447217002222	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217002223	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
447217002224	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
447217002225	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217002226	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217002227	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217002228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217002230	DNA binding residues [nucleotide binding]
447217002231	Putative zinc-finger; Region: zf-HC2; cl15806
447217002232	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217002233	heme-binding residues [chemical binding]; other site
447217002234	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002235	molybdopterin cofactor binding site; other site
447217002236	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
447217002237	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
447217002238	4Fe-4S binding domain; Region: Fer4; cl02805
447217002239	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217002240	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
447217002241	Cytochrome c; Region: Cytochrom_C; cl11414
447217002242	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
447217002243	Cu(I) binding site [ion binding]; other site
447217002244	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
447217002245	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217002246	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
447217002247	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217002248	D-pathway; other site
447217002249	Low-spin heme binding site [chemical binding]; other site
447217002250	Putative water exit pathway; other site
447217002251	Binuclear center (active site) [active]
447217002252	K-pathway; other site
447217002253	Putative proton exit pathway; other site
447217002254	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
447217002255	Subunit I/III interface [polypeptide binding]; other site
447217002256	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
447217002257	Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751
447217002258	thiamine pyrophosphate protein; Provisional; Region: PRK08273
447217002259	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
447217002260	PYR/PP interface [polypeptide binding]; other site
447217002261	tetramer interface [polypeptide binding]; other site
447217002262	dimer interface [polypeptide binding]; other site
447217002263	TPP binding site [chemical binding]; other site
447217002264	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
447217002265	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
447217002266	TPP-binding site [chemical binding]; other site
447217002267	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
447217002268	metal binding site [ion binding]; metal-binding site
447217002269	substrate binding pocket [chemical binding]; other site
447217002270	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217002271	FAD binding domain; Region: FAD_binding_4; pfam01565
447217002272	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
447217002273	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
447217002274	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
447217002275	putative ADP-ribose binding site [chemical binding]; other site
447217002276	putative active site [active]
447217002277	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002279	active site
447217002280	phosphorylation site [posttranslational modification]
447217002281	intermolecular recognition site; other site
447217002282	dimerization interface [polypeptide binding]; other site
447217002283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002284	Walker A motif; other site
447217002285	ATP binding site [chemical binding]; other site
447217002286	Walker B motif; other site
447217002287	arginine finger; other site
447217002288	Helix-turn-helix domains; Region: HTH; cl00088
447217002289	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217002290	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217002291	ResB-like family; Region: ResB; pfam05140
447217002292	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
447217002293	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
447217002294	active site
447217002295	DNA binding site [nucleotide binding]
447217002296	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
447217002297	DNA binding site [nucleotide binding]
447217002298	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
447217002299	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
447217002300	active site
447217002301	dimer interface [polypeptide binding]; other site
447217002302	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
447217002303	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
447217002304	active site
447217002305	FMN binding site [chemical binding]; other site
447217002306	substrate binding site [chemical binding]; other site
447217002307	3Fe-4S cluster binding site [ion binding]; other site
447217002308	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
447217002309	domain interface; other site
447217002310	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
447217002311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002312	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
447217002313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002315	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
447217002316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217002317	FeS/SAM binding site; other site
447217002318	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
447217002319	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217002320	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
447217002321	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
447217002322	4Fe-4S binding domain; Region: Fer4; cl02805
447217002323	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217002324	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002325	molybdopterin cofactor binding site; other site
447217002326	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002327	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217002328	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217002329	molybdopterin cofactor binding site; other site
447217002330	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
447217002331	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002332	Walker A motif; other site
447217002333	ATP binding site [chemical binding]; other site
447217002334	Family description; Region: UvrD_C_2; cl15862
447217002335	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
447217002336	dimer interface [polypeptide binding]; other site
447217002337	catalytic triad [active]
447217002338	peroxidatic and resolving cysteines [active]
447217002339	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217002340	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217002341	ABC transporter; Region: ABC_tran_2; pfam12848
447217002342	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217002343	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002344	Walker A/P-loop; other site
447217002345	ATP binding site [chemical binding]; other site
447217002346	Q-loop/lid; other site
447217002347	ABC transporter signature motif; other site
447217002348	Walker B; other site
447217002349	D-loop; other site
447217002350	H-loop/switch region; other site
447217002351	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
447217002352	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
447217002353	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
447217002354	Glutamate binding site [chemical binding]; other site
447217002355	NAD binding site [chemical binding]; other site
447217002356	catalytic residues [active]
447217002357	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002359	active site
447217002360	phosphorylation site [posttranslational modification]
447217002361	intermolecular recognition site; other site
447217002362	dimerization interface [polypeptide binding]; other site
447217002363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002364	Walker A motif; other site
447217002365	ATP binding site [chemical binding]; other site
447217002366	Walker B motif; other site
447217002367	arginine finger; other site
447217002368	Helix-turn-helix domains; Region: HTH; cl00088
447217002369	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002370	dimer interface [polypeptide binding]; other site
447217002371	phosphorylation site [posttranslational modification]
447217002372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002373	ATP binding site [chemical binding]; other site
447217002374	Mg2+ binding site [ion binding]; other site
447217002375	G-X-G motif; other site
447217002376	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
447217002377	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
447217002378	Walker A/P-loop; other site
447217002379	ATP binding site [chemical binding]; other site
447217002380	Q-loop/lid; other site
447217002381	ABC transporter signature motif; other site
447217002382	Walker B; other site
447217002383	D-loop; other site
447217002384	H-loop/switch region; other site
447217002385	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217002386	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217002387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217002388	ATP binding site [chemical binding]; other site
447217002389	putative Mg++ binding site [ion binding]; other site
447217002390	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217002391	nucleotide binding region [chemical binding]; other site
447217002392	ATP-binding site [chemical binding]; other site
447217002393	HRDC domain; Region: HRDC; cl02578
447217002394	YaeQ protein; Region: YaeQ; cl01913
447217002395	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
447217002396	Helix-turn-helix domains; Region: HTH; cl00088
447217002397	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
447217002398	putative ABC transporter; Region: ycf24; CHL00085
447217002399	FeS assembly ATPase SufC; Region: sufC; TIGR01978
447217002400	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
447217002401	Walker A/P-loop; other site
447217002402	ATP binding site [chemical binding]; other site
447217002403	Q-loop/lid; other site
447217002404	ABC transporter signature motif; other site
447217002405	Walker B; other site
447217002406	D-loop; other site
447217002407	H-loop/switch region; other site
447217002408	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
447217002409	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217002410	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
447217002411	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217002412	catalytic residue [active]
447217002413	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
447217002414	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
447217002415	trimerization site [polypeptide binding]; other site
447217002416	active site
447217002417	Domain of unknown function DUF59; Region: DUF59; cl00941
447217002418	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217002419	phosphopeptide binding site; other site
447217002420	Domain of unknown function (DUF305); Region: DUF305; cl15795
447217002421	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217002422	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217002423	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217002424	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217002425	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217002426	protein binding site [polypeptide binding]; other site
447217002427	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217002428	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217002429	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217002430	FtsX-like permease family; Region: FtsX; cl15850
447217002431	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217002432	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217002433	protein binding site [polypeptide binding]; other site
447217002434	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217002435	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217002436	protein binding site [polypeptide binding]; other site
447217002437	transcriptional regulator FimZ; Provisional; Region: PRK09935
447217002438	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217002439	DNA binding residues [nucleotide binding]
447217002440	dimerization interface [polypeptide binding]; other site
447217002441	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217002442	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002443	active site
447217002444	The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229
447217002445	Predicted RNA interaction site [nucleotide binding]; other site
447217002446	putative binding site; other site
447217002447	Mutations affecting start-site selection; other site
447217002448	TfuA-like protein; Region: TfuA; pfam07812
447217002449	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
447217002450	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
447217002451	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
447217002452	active site
447217002453	metal binding site [ion binding]; metal-binding site
447217002454	dimer interface [polypeptide binding]; other site
447217002455	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
447217002456	homodimer interface [polypeptide binding]; other site
447217002457	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
447217002458	active site pocket [active]
447217002459	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217002460	LemA family; Region: LemA; cl00742
447217002461	Repair protein; Region: Repair_PSII; cl01535
447217002462	Repair protein; Region: Repair_PSII; cl01535
447217002463	potassium/proton antiporter; Reviewed; Region: PRK05326
447217002464	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217002465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217002466	non-specific DNA binding site [nucleotide binding]; other site
447217002467	salt bridge; other site
447217002468	sequence-specific DNA binding site [nucleotide binding]; other site
447217002469	Cupin domain; Region: Cupin_2; cl09118
447217002470	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217002471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002472	active site
447217002473	phosphorylation site [posttranslational modification]
447217002474	intermolecular recognition site; other site
447217002475	dimerization interface [polypeptide binding]; other site
447217002476	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
447217002477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217002478	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217002479	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
447217002480	active site
447217002481	Substrate binding site; other site
447217002482	Mg++ binding site; other site
447217002483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217002484	S-adenosylmethionine binding site [chemical binding]; other site
447217002485	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
447217002486	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217002487	ligand binding site [chemical binding]; other site
447217002488	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
447217002489	Domain of unknown function (DUF305); Region: DUF305; cl15795
447217002490	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
447217002491	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
447217002492	active site
447217002493	DNA binding site [nucleotide binding]
447217002494	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
447217002495	nucleotide binding site [chemical binding]; other site
447217002496	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
447217002497	Mechanosensitive ion channel; Region: MS_channel; pfam00924
447217002498	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
447217002499	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217002500	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217002501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217002502	TPR motif; other site
447217002503	binding surface
447217002504	exosortase E/protease, VPEID-CTERM system; Region: exo_VPEID; TIGR04162
447217002505	CAAX protease self-immunity; Region: Abi; cl00558
447217002506	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
447217002507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002508	active site
447217002509	phosphorylation site [posttranslational modification]
447217002510	intermolecular recognition site; other site
447217002511	dimerization interface [polypeptide binding]; other site
447217002512	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217002513	DNA binding site [nucleotide binding]
447217002514	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
447217002515	GAF domain; Region: GAF; cl15785
447217002516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002517	dimer interface [polypeptide binding]; other site
447217002518	phosphorylation site [posttranslational modification]
447217002519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002520	ATP binding site [chemical binding]; other site
447217002521	Mg2+ binding site [ion binding]; other site
447217002522	G-X-G motif; other site
447217002523	Amino acid permease; Region: AA_permease_2; pfam13520
447217002524	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
447217002525	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
447217002526	ligand binding site; other site
447217002527	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
447217002528	dimerization interface [polypeptide binding]; other site
447217002529	Protein of unknown function (DUF420); Region: DUF420; cl00989
447217002530	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217002531	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
447217002532	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
447217002533	Walker A/P-loop; other site
447217002534	ATP binding site [chemical binding]; other site
447217002535	Q-loop/lid; other site
447217002536	ABC transporter signature motif; other site
447217002537	Walker B; other site
447217002538	D-loop; other site
447217002539	H-loop/switch region; other site
447217002540	UbiA prenyltransferase family; Region: UbiA; cl00337
447217002541	TIGR02300 family protein; Region: FYDLN_acid
447217002542	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
447217002543	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
447217002544	Ligand Binding Site [chemical binding]; other site
447217002545	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
447217002546	catalytic residue [active]
447217002547	Sulfatase; Region: Sulfatase; cl10460
447217002548	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
447217002549	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
447217002550	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
447217002551	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
447217002552	[4Fe-4S] binding site [ion binding]; other site
447217002553	molybdopterin cofactor binding site; other site
447217002554	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
447217002555	molybdopterin cofactor binding site; other site
447217002556	Cytochrome c552; Region: Cytochrom_C552; pfam02335
447217002557	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217002558	multicopper oxidase; Provisional; Region: PRK10965
447217002559	multicopper oxidase; Provisional; Region: PRK10965
447217002560	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217002561	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217002562	Interdomain contacts; other site
447217002563	Cytokine receptor motif; other site
447217002564	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217002565	Interdomain contacts; other site
447217002566	Cytokine receptor motif; other site
447217002567	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
447217002568	hydrophobic ligand binding site; other site
447217002569	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
447217002570	anti sigma factor interaction site; other site
447217002571	regulatory phosphorylation site [posttranslational modification]; other site
447217002572	Glycine radical; Region: Gly_radical; cl12026
447217002573	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217002574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217002575	dimerization interface [polypeptide binding]; other site
447217002576	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
447217002577	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
447217002578	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
447217002579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002580	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
447217002581	urease subunit alpha; Reviewed; Region: ureC; PRK13207
447217002582	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
447217002583	subunit interactions [polypeptide binding]; other site
447217002584	active site
447217002585	flap region; other site
447217002586	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
447217002587	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
447217002588	alpha-gamma subunit interface [polypeptide binding]; other site
447217002589	beta-gamma subunit interface [polypeptide binding]; other site
447217002590	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
447217002591	alpha-beta subunit interface [polypeptide binding]; other site
447217002592	UreD urease accessory protein; Region: UreD; cl00530
447217002593	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002595	active site
447217002596	phosphorylation site [posttranslational modification]
447217002597	intermolecular recognition site; other site
447217002598	dimerization interface [polypeptide binding]; other site
447217002599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002600	Walker A motif; other site
447217002601	ATP binding site [chemical binding]; other site
447217002602	Walker B motif; other site
447217002603	arginine finger; other site
447217002604	Helix-turn-helix domains; Region: HTH; cl00088
447217002605	sensory histidine kinase AtoS; Provisional; Region: PRK11360
447217002606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002607	dimer interface [polypeptide binding]; other site
447217002608	phosphorylation site [posttranslational modification]
447217002609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002610	ATP binding site [chemical binding]; other site
447217002611	Mg2+ binding site [ion binding]; other site
447217002612	G-X-G motif; other site
447217002613	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217002614	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
447217002615	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
447217002616	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217002617	homodimer interface [polypeptide binding]; other site
447217002618	substrate-cofactor binding pocket; other site
447217002619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217002620	catalytic residue [active]
447217002621	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217002622	AMP-binding enzyme; Region: AMP-binding; cl15778
447217002623	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
447217002624	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217002625	DTAP/Switch II; other site
447217002626	Switch I; other site
447217002627	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
447217002628	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217002629	DTAP/Switch II; other site
447217002630	Switch I; other site
447217002631	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
447217002632	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217002633	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002634	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217002635	Magnesium ion binding site [ion binding]; other site
447217002636	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217002637	Helix-turn-helix domains; Region: HTH; cl00088
447217002638	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217002639	putative effector binding pocket; other site
447217002640	dimerization interface [polypeptide binding]; other site
447217002641	YceI-like domain; Region: YceI; cl01001
447217002642	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
447217002643	putative active site [active]
447217002644	metal binding site [ion binding]; metal-binding site
447217002645	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
447217002646	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217002647	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
447217002648	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
447217002649	active site
447217002650	catalytic site [active]
447217002651	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
447217002652	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
447217002653	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217002654	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
447217002655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217002656	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
447217002657	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
447217002658	tetramer interface [polypeptide binding]; other site
447217002659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217002660	catalytic residue [active]
447217002661	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
447217002662	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
447217002663	catalytic residues [active]
447217002664	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217002665	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217002666	active site
447217002667	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
447217002668	hypothetical protein; Reviewed; Region: PRK09588
447217002669	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
447217002670	multidrug efflux protein; Reviewed; Region: PRK01766
447217002671	MatE; Region: MatE; cl10513
447217002672	MatE; Region: MatE; cl10513
447217002673	potassium uptake protein; Region: kup; TIGR00794
447217002674	K+ potassium transporter; Region: K_trans; cl15781
447217002675	Transmembrane secretion effector; Region: MFS_3; pfam05977
447217002676	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
447217002677	active site
447217002678	putative DNA-binding cleft [nucleotide binding]; other site
447217002679	dimer interface [polypeptide binding]; other site
447217002680	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
447217002681	RuvA N terminal domain; Region: RuvA_N; pfam01330
447217002682	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
447217002683	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
447217002684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002685	Walker A motif; other site
447217002686	ATP binding site [chemical binding]; other site
447217002687	Walker B motif; other site
447217002688	arginine finger; other site
447217002689	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
447217002690	Rhomboid family; Region: Rhomboid; cl11446
447217002691	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
447217002692	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
447217002693	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
447217002694	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
447217002695	putative hydrophobic ligand binding site [chemical binding]; other site
447217002696	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
447217002697	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
447217002698	nucleotide binding site [chemical binding]; other site
447217002699	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
447217002700	putative DNA binding site [nucleotide binding]; other site
447217002701	putative homodimer interface [polypeptide binding]; other site
447217002702	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
447217002703	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
447217002704	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
447217002705	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
447217002706	Response regulator receiver domain; Region: Response_reg; pfam00072
447217002707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002708	active site
447217002709	phosphorylation site [posttranslational modification]
447217002710	intermolecular recognition site; other site
447217002711	dimerization interface [polypeptide binding]; other site
447217002712	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
447217002713	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
447217002714	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
447217002715	DNA binding site [nucleotide binding]
447217002716	active site
447217002717	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
447217002718	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
447217002719	AlkA N-terminal domain; Region: AlkA_N; cl05528
447217002720	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
447217002721	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217002722	helix-hairpin-helix signature motif; other site
447217002723	substrate binding pocket [chemical binding]; other site
447217002724	active site
447217002725	Cupin domain; Region: Cupin_2; cl09118
447217002726	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217002727	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217002728	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217002729	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
447217002730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002731	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217002732	Walker A motif; other site
447217002733	ATP binding site [chemical binding]; other site
447217002734	Walker B motif; other site
447217002735	arginine finger; other site
447217002736	Helix-turn-helix domains; Region: HTH; cl00088
447217002737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217002738	putative substrate translocation pore; other site
447217002739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217002740	Helix-turn-helix domains; Region: HTH; cl00088
447217002741	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002742	dimerization interface [polypeptide binding]; other site
447217002743	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
447217002744	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
447217002745	Peptidase family M48; Region: Peptidase_M48; cl12018
447217002746	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
447217002747	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217002748	DNA-binding site [nucleotide binding]; DNA binding site
447217002749	RNA-binding motif; other site
447217002750	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217002751	active site
447217002752	metal binding site [ion binding]; metal-binding site
447217002753	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217002754	putative active site [active]
447217002755	catalytic site [active]
447217002756	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
447217002757	PLD-like domain; Region: PLDc_2; pfam13091
447217002758	putative active site [active]
447217002759	catalytic site [active]
447217002760	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
447217002761	homodimer interaction site [polypeptide binding]; other site
447217002762	cofactor binding site; other site
447217002763	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217002764	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217002765	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217002766	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217002767	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
447217002768	putative ligand binding site [chemical binding]; other site
447217002769	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002770	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002771	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002772	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002773	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002774	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002775	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002776	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002777	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002778	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
447217002779	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
447217002780	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002781	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
447217002782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217002783	Coenzyme A binding pocket [chemical binding]; other site
447217002784	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
447217002785	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
447217002786	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002787	Walker A/P-loop; other site
447217002788	ATP binding site [chemical binding]; other site
447217002789	Q-loop/lid; other site
447217002790	ABC transporter signature motif; other site
447217002791	Walker B; other site
447217002792	D-loop; other site
447217002793	H-loop/switch region; other site
447217002794	TOBE domain; Region: TOBE_2; cl01440
447217002795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217002796	putative PBP binding loops; other site
447217002797	ABC-ATPase subunit interface; other site
447217002798	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217002799	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002800	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
447217002801	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002802	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
447217002803	putative ligand binding site [chemical binding]; other site
447217002804	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
447217002805	TM-ABC transporter signature motif; other site
447217002806	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
447217002807	TM-ABC transporter signature motif; other site
447217002808	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
447217002809	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
447217002810	Walker A/P-loop; other site
447217002811	ATP binding site [chemical binding]; other site
447217002812	Q-loop/lid; other site
447217002813	ABC transporter signature motif; other site
447217002814	Walker B; other site
447217002815	D-loop; other site
447217002816	H-loop/switch region; other site
447217002817	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
447217002818	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217002819	active site
447217002820	YCII-related domain; Region: YCII; cl00999
447217002821	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
447217002822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217002823	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217002824	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217002825	active site
447217002826	Helix-turn-helix domains; Region: HTH; cl00088
447217002827	WYL domain; Region: WYL; cl14852
447217002828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002829	NAD(P) binding site [chemical binding]; other site
447217002830	active site
447217002831	hypothetical protein; Provisional; Region: PRK05858
447217002832	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
447217002833	PYR/PP interface [polypeptide binding]; other site
447217002834	dimer interface [polypeptide binding]; other site
447217002835	TPP binding site [chemical binding]; other site
447217002836	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
447217002837	TPP-binding site [chemical binding]; other site
447217002838	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
447217002839	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217002840	putative ADP-binding pocket [chemical binding]; other site
447217002841	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217002842	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
447217002843	Outer membrane efflux protein; Region: OEP; pfam02321
447217002844	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217002845	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217002846	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217002847	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217002848	Fatty acid desaturase; Region: FA_desaturase; pfam00487
447217002849	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
447217002850	putative di-iron ligands [ion binding]; other site
447217002851	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
447217002852	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217002853	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
447217002854	Helix-turn-helix domains; Region: HTH; cl00088
447217002855	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217002856	dimerization interface [polypeptide binding]; other site
447217002857	rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179
447217002858	Rhomboid family; Region: Rhomboid; cl11446
447217002859	Helix-turn-helix domains; Region: HTH; cl00088
447217002860	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
447217002861	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
447217002862	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217002863	active site
447217002864	nucleotide binding site [chemical binding]; other site
447217002865	HIGH motif; other site
447217002866	KMSKS motif; other site
447217002867	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
447217002868	CoA-binding site [chemical binding]; other site
447217002869	ATP-binding [chemical binding]; other site
447217002870	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217002871	Isochorismatase family; Region: Isochorismatase; pfam00857
447217002872	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
447217002873	catalytic triad [active]
447217002874	dimer interface [polypeptide binding]; other site
447217002875	conserved cis-peptide bond; other site
447217002876	4Fe-4S binding domain; Region: Fer4; cl02805
447217002877	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
447217002878	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
447217002879	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
447217002880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217002881	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
447217002882	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
447217002883	active site
447217002884	HIGH motif; other site
447217002885	dimer interface [polypeptide binding]; other site
447217002886	KMSKS motif; other site
447217002887	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
447217002888	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217002889	putative active site [active]
447217002890	metal binding site [ion binding]; metal-binding site
447217002891	homodimer binding site [polypeptide binding]; other site
447217002892	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
447217002893	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217002894	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217002895	active site
447217002896	ATP binding site [chemical binding]; other site
447217002897	substrate binding site [chemical binding]; other site
447217002898	activation loop (A-loop); other site
447217002899	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217002900	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
447217002901	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217002902	catalytic residue [active]
447217002903	DHH family; Region: DHH; pfam01368
447217002904	endonuclease IV; Provisional; Region: PRK01060
447217002905	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
447217002906	AP (apurinic/apyrimidinic) site pocket; other site
447217002907	DNA interaction; other site
447217002908	Metal-binding active site; metal-binding site
447217002909	Fic/DOC family; Region: Fic; cl00960
447217002910	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
447217002911	homodimer interface [polypeptide binding]; other site
447217002912	substrate-cofactor binding pocket; other site
447217002913	catalytic residue [active]
447217002914	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217002915	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217002916	metal binding triad; other site
447217002917	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217002918	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217002919	metal binding triad; other site
447217002920	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217002921	Transposase domain (DUF772); Region: DUF772; cl15789
447217002922	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217002923	Transposase domain (DUF772); Region: DUF772; cl15789
447217002924	Transposase domain (DUF772); Region: DUF772; cl15789
447217002925	Transposase domain (DUF772); Region: DUF772; cl15789
447217002926	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217002927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217002928	active site
447217002929	phosphorylation site [posttranslational modification]
447217002930	intermolecular recognition site; other site
447217002931	dimerization interface [polypeptide binding]; other site
447217002932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217002933	Walker A motif; other site
447217002934	ATP binding site [chemical binding]; other site
447217002935	Walker B motif; other site
447217002936	arginine finger; other site
447217002937	Helix-turn-helix domains; Region: HTH; cl00088
447217002938	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
447217002939	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
447217002940	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
447217002941	active site
447217002942	catalytic site [active]
447217002943	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
447217002944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002945	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217002946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217002948	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217002949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217002950	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217002951	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217002952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002953	NAD(P) binding site [chemical binding]; other site
447217002954	active site
447217002955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002956	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
447217002957	NAD(P) binding site [chemical binding]; other site
447217002958	active site
447217002959	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217002960	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
447217002961	putative NAD(P) binding site [chemical binding]; other site
447217002962	catalytic Zn binding site [ion binding]; other site
447217002963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002964	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
447217002965	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217002966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
447217002967	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217002968	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
447217002969	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
447217002970	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
447217002971	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
447217002972	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217002973	Walker A/P-loop; other site
447217002974	ATP binding site [chemical binding]; other site
447217002975	Q-loop/lid; other site
447217002976	ABC transporter signature motif; other site
447217002977	Walker B; other site
447217002978	D-loop; other site
447217002979	H-loop/switch region; other site
447217002980	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217002981	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217002982	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
447217002983	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217002984	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217002985	DNA binding residues [nucleotide binding]
447217002986	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
447217002987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217002988	NAD(P) binding site [chemical binding]; other site
447217002989	active site
447217002990	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
447217002991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217002992	dimerization interface [polypeptide binding]; other site
447217002993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217002994	dimer interface [polypeptide binding]; other site
447217002995	phosphorylation site [posttranslational modification]
447217002996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217002997	ATP binding site [chemical binding]; other site
447217002998	Mg2+ binding site [ion binding]; other site
447217002999	G-X-G motif; other site
447217003000	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
447217003001	Surface antigen; Region: Bac_surface_Ag; cl03097
447217003002	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217003003	active site
447217003004	ATP binding site [chemical binding]; other site
447217003005	substrate binding site [chemical binding]; other site
447217003006	activation loop (A-loop); other site
447217003007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
447217003008	Uncharacterized conserved protein [Function unknown]; Region: COG1543
447217003009	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
447217003010	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
447217003011	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
447217003012	dimer interface [polypeptide binding]; other site
447217003013	putative anticodon binding site; other site
447217003014	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
447217003015	motif 1; other site
447217003016	active site
447217003017	motif 2; other site
447217003018	motif 3; other site
447217003019	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
447217003020	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217003021	FtsX-like permease family; Region: FtsX; cl15850
447217003022	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
447217003023	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217003024	Walker A/P-loop; other site
447217003025	ATP binding site [chemical binding]; other site
447217003026	Q-loop/lid; other site
447217003027	ABC transporter signature motif; other site
447217003028	Walker B; other site
447217003029	D-loop; other site
447217003030	H-loop/switch region; other site
447217003031	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217003032	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
447217003033	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217003034	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217003035	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217003036	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
447217003037	Surface antigen; Region: Bac_surface_Ag; cl03097
447217003038	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
447217003039	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
447217003040	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
447217003041	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
447217003042	trimer interface [polypeptide binding]; other site
447217003043	active site
447217003044	UDP-GlcNAc binding site [chemical binding]; other site
447217003045	lipid binding site [chemical binding]; lipid-binding site
447217003046	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
447217003047	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
447217003048	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
447217003049	active site
447217003050	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
447217003051	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
447217003052	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
447217003053	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
447217003054	substrate binding site [chemical binding]; other site
447217003055	active site
447217003056	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
447217003057	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217003058	FeS/SAM binding site; other site
447217003059	HemN C-terminal domain; Region: HemN_C; pfam06969
447217003060	Ferrochelatase; Region: Ferrochelatase; pfam00762
447217003061	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
447217003062	C-terminal domain interface [polypeptide binding]; other site
447217003063	active site
447217003064	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
447217003065	active site
447217003066	N-terminal domain interface [polypeptide binding]; other site
447217003067	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217003068	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
447217003069	TPR repeat; Region: TPR_11; pfam13414
447217003070	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
447217003071	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217003072	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
447217003073	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
447217003074	generic binding surface II; other site
447217003075	generic binding surface I; other site
447217003076	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
447217003077	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003079	active site
447217003080	phosphorylation site [posttranslational modification]
447217003081	intermolecular recognition site; other site
447217003082	dimerization interface [polypeptide binding]; other site
447217003083	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
447217003084	substrate binding pocket [chemical binding]; other site
447217003085	aspartate-rich region 1; other site
447217003086	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
447217003087	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
447217003088	TPP-binding site; other site
447217003089	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
447217003090	PYR/PP interface [polypeptide binding]; other site
447217003091	dimer interface [polypeptide binding]; other site
447217003092	TPP binding site [chemical binding]; other site
447217003093	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
447217003094	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
447217003095	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217003096	RNA binding surface [nucleotide binding]; other site
447217003097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217003098	ribosome maturation protein RimP; Reviewed; Region: PRK00092
447217003099	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
447217003100	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
447217003101	Sm1 motif; other site
447217003102	D3 - B interaction site; other site
447217003103	D1 - D2 interaction site; other site
447217003104	Hfq - Hfq interaction site; other site
447217003105	RNA binding pocket [nucleotide binding]; other site
447217003106	Sm2 motif; other site
447217003107	NusA N-terminal domain; Region: NusA_N; pfam08529
447217003108	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
447217003109	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
447217003110	RNA binding site [nucleotide binding]; other site
447217003111	homodimer interface [polypeptide binding]; other site
447217003112	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
447217003113	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
447217003114	G-X-X-G motif; other site
447217003115	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
447217003116	putative RNA binding cleft [nucleotide binding]; other site
447217003117	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
447217003118	translation initiation factor IF-2; Region: IF-2; TIGR00487
447217003119	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
447217003120	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
447217003121	G1 box; other site
447217003122	putative GEF interaction site [polypeptide binding]; other site
447217003123	GTP/Mg2+ binding site [chemical binding]; other site
447217003124	Switch I region; other site
447217003125	G2 box; other site
447217003126	G3 box; other site
447217003127	Switch II region; other site
447217003128	G4 box; other site
447217003129	G5 box; other site
447217003130	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
447217003131	Translation-initiation factor 2; Region: IF-2; pfam11987
447217003132	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
447217003133	Protein of unknown function (DUF503); Region: DUF503; cl00669
447217003134	Ribosome-binding factor A; Region: RBFA; cl00542
447217003135	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
447217003136	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
447217003137	RNA binding site [nucleotide binding]; other site
447217003138	active site
447217003139	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
447217003140	16S/18S rRNA binding site [nucleotide binding]; other site
447217003141	S13e-L30e interaction site [polypeptide binding]; other site
447217003142	25S rRNA binding site [nucleotide binding]; other site
447217003143	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
447217003144	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
447217003145	RNase E interface [polypeptide binding]; other site
447217003146	trimer interface [polypeptide binding]; other site
447217003147	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
447217003148	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
447217003149	RNase E interface [polypeptide binding]; other site
447217003150	trimer interface [polypeptide binding]; other site
447217003151	active site
447217003152	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
447217003153	putative nucleic acid binding region [nucleotide binding]; other site
447217003154	G-X-X-G motif; other site
447217003155	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
447217003156	RNA binding site [nucleotide binding]; other site
447217003157	domain interface; other site
447217003158	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
447217003159	trimer interface [polypeptide binding]; other site
447217003160	active site
447217003161	adenylosuccinate lyase; Provisional; Region: PRK07492
447217003162	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
447217003163	tetramer interface [polypeptide binding]; other site
447217003164	active site
447217003165	GAF domain; Region: GAF; cl15785
447217003166	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217003167	dimer interface [polypeptide binding]; other site
447217003168	phosphorylation site [posttranslational modification]
447217003169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217003170	ATP binding site [chemical binding]; other site
447217003171	Mg2+ binding site [ion binding]; other site
447217003172	G-X-G motif; other site
447217003173	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
447217003174	ATP binding site [chemical binding]; other site
447217003175	active site
447217003176	substrate binding site [chemical binding]; other site
447217003177	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
447217003178	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
447217003179	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217003180	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217003181	protein binding site [polypeptide binding]; other site
447217003182	phosphoglycolate phosphatase; Provisional; Region: PRK13222
447217003183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217003184	motif II; other site
447217003185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217003186	dimerization interface [polypeptide binding]; other site
447217003187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003188	Zn2+ binding site [ion binding]; other site
447217003189	Mg2+ binding site [ion binding]; other site
447217003190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003191	active site
447217003192	phosphorylation site [posttranslational modification]
447217003193	intermolecular recognition site; other site
447217003194	dimerization interface [polypeptide binding]; other site
447217003195	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
447217003196	MoaE interaction surface [polypeptide binding]; other site
447217003197	MoeB interaction surface [polypeptide binding]; other site
447217003198	thiocarboxylated glycine; other site
447217003199	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
447217003200	MoaE homodimer interface [polypeptide binding]; other site
447217003201	MoaD interaction [polypeptide binding]; other site
447217003202	active site residues [active]
447217003203	RIP metalloprotease RseP; Region: TIGR00054
447217003204	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217003205	active site
447217003206	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217003207	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
447217003208	putative substrate binding region [chemical binding]; other site
447217003209	AMMECR1; Region: AMMECR1; cl00911
447217003210	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
447217003211	nudix motif; other site
447217003212	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
447217003213	active site clefts [active]
447217003214	zinc binding site [ion binding]; other site
447217003215	dimer interface [polypeptide binding]; other site
447217003216	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
447217003217	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
447217003218	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
447217003219	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
447217003220	EamA-like transporter family; Region: EamA; cl01037
447217003221	EamA-like transporter family; Region: EamA; cl01037
447217003222	PAS fold; Region: PAS_4; pfam08448
447217003223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217003224	putative active site [active]
447217003225	heme pocket [chemical binding]; other site
447217003226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
447217003227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217003228	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217003229	dimer interface [polypeptide binding]; other site
447217003230	phosphorylation site [posttranslational modification]
447217003231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217003232	ATP binding site [chemical binding]; other site
447217003233	Mg2+ binding site [ion binding]; other site
447217003234	G-X-G motif; other site
447217003235	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217003236	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217003237	active site
447217003238	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
447217003239	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217003240	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003241	active site
447217003242	ATP binding site [chemical binding]; other site
447217003243	substrate binding site [chemical binding]; other site
447217003244	activation loop (A-loop); other site
447217003245	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
447217003246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003247	active site
447217003248	phosphorylation site [posttranslational modification]
447217003249	intermolecular recognition site; other site
447217003250	dimerization interface [polypeptide binding]; other site
447217003251	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003252	Zn2+ binding site [ion binding]; other site
447217003253	Mg2+ binding site [ion binding]; other site
447217003254	transcription termination factor Rho; Provisional; Region: PRK12608
447217003255	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217003256	Walker A motif; other site
447217003257	ATP binding site [chemical binding]; other site
447217003258	Walker B motif; other site
447217003259	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
447217003260	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
447217003261	oligomer interface [polypeptide binding]; other site
447217003262	tandem repeat interface [polypeptide binding]; other site
447217003263	active site residues [active]
447217003264	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
447217003265	tandem repeat interface [polypeptide binding]; other site
447217003266	oligomer interface [polypeptide binding]; other site
447217003267	active site residues [active]
447217003268	Thymidylate synthase complementing protein; Region: Thy1; cl03630
447217003269	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217003270	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
447217003271	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
447217003272	active site
447217003273	Zn binding site [ion binding]; other site
447217003274	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003275	phosphopeptide binding site; other site
447217003276	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
447217003277	NAD(P) binding site [chemical binding]; other site
447217003278	catalytic residues [active]
447217003279	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
447217003280	putative active site [active]
447217003281	putative metal binding site [ion binding]; other site
447217003282	Uncharacterized conserved protein [Function unknown]; Region: COG3342
447217003283	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
447217003284	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
447217003285	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
447217003286	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
447217003287	dimer interface [polypeptide binding]; other site
447217003288	decamer (pentamer of dimers) interface [polypeptide binding]; other site
447217003289	catalytic triad [active]
447217003290	peroxidatic and resolving cysteines [active]
447217003291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003292	non-specific DNA binding site [nucleotide binding]; other site
447217003293	salt bridge; other site
447217003294	sequence-specific DNA binding site [nucleotide binding]; other site
447217003295	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
447217003296	dimer interface [polypeptide binding]; other site
447217003297	catalytic triad [active]
447217003298	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409
447217003299	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217003300	Haemolysin-III related; Region: HlyIII; cl03831
447217003301	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217003302	G1 box; other site
447217003303	GTP/Mg2+ binding site [chemical binding]; other site
447217003304	G2 box; other site
447217003305	Switch I region; other site
447217003306	G3 box; other site
447217003307	Switch II region; other site
447217003308	G4 box; other site
447217003309	G5 box; other site
447217003310	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
447217003311	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
447217003312	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
447217003313	heterotetramer interface [polypeptide binding]; other site
447217003314	active site pocket [active]
447217003315	cleavage site
447217003316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217003317	S-adenosylmethionine binding site [chemical binding]; other site
447217003318	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217003319	dimerization interface [polypeptide binding]; other site
447217003320	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217003321	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217003322	dimer interface [polypeptide binding]; other site
447217003323	putative CheW interface [polypeptide binding]; other site
447217003324	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217003325	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217003326	putative NAD(P) binding site [chemical binding]; other site
447217003327	putative substrate binding site [chemical binding]; other site
447217003328	catalytic Zn binding site [ion binding]; other site
447217003329	structural Zn binding site [ion binding]; other site
447217003330	dimer interface [polypeptide binding]; other site
447217003331	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
447217003332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003333	NAD(P) binding site [chemical binding]; other site
447217003334	active site
447217003335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003336	NAD(P) binding site [chemical binding]; other site
447217003337	active site
447217003338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003339	active site
447217003340	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
447217003341	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217003342	AMP-binding enzyme; Region: AMP-binding; cl15778
447217003343	Phosphopantetheine attachment site; Region: PP-binding; cl09936
447217003344	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217003345	putative acyl-acceptor binding pocket; other site
447217003346	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
447217003347	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
447217003348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217003349	motif II; other site
447217003350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003351	NAD(P) binding site [chemical binding]; other site
447217003352	active site
447217003353	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
447217003354	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
447217003355	putative [4Fe-4S] binding site [ion binding]; other site
447217003356	putative molybdopterin cofactor binding site [chemical binding]; other site
447217003357	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
447217003358	putative molybdopterin cofactor binding site; other site
447217003359	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217003360	Low-spin heme binding site [chemical binding]; other site
447217003361	D-pathway; other site
447217003362	Putative water exit pathway; other site
447217003363	Binuclear center (active site) [active]
447217003364	K-pathway; other site
447217003365	Putative proton exit pathway; other site
447217003366	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
447217003367	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
447217003368	Cytochrome c; Region: Cytochrom_C; cl11414
447217003369	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
447217003370	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
447217003371	4Fe-4S binding domain; Region: Fer4_5; pfam12801
447217003372	4Fe-4S binding domain; Region: Fer4; cl02805
447217003373	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
447217003374	FixH; Region: FixH; cl01254
447217003375	FixH; Region: FixH; cl01254
447217003376	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217003377	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
447217003378	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
447217003379	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
447217003380	metal-binding site [ion binding]
447217003381	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217003382	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
447217003383	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
447217003384	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
447217003385	substrate binding site [chemical binding]; other site
447217003386	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
447217003387	substrate binding site [chemical binding]; other site
447217003388	ligand binding site [chemical binding]; other site
447217003389	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
447217003390	nudix motif; other site
447217003391	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217003392	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
447217003393	heme-binding residues [chemical binding]; other site
447217003394	aspartate ammonia-lyase; Provisional; Region: PRK13353
447217003395	Aspartase; Region: Aspartase; cd01357
447217003396	active sites [active]
447217003397	tetramer interface [polypeptide binding]; other site
447217003398	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217003399	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
447217003400	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217003401	active site
447217003402	HIGH motif; other site
447217003403	nucleotide binding site [chemical binding]; other site
447217003404	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
447217003405	KMSKS motif; other site
447217003406	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
447217003407	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
447217003408	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
447217003409	active site
447217003410	HIGH motif; other site
447217003411	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
447217003412	active site
447217003413	KMSKS motif; other site
447217003414	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217003415	active site
447217003416	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
447217003417	putative ligand binding pocket/active site [active]
447217003418	putative metal binding site [ion binding]; other site
447217003419	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003421	active site
447217003422	phosphorylation site [posttranslational modification]
447217003423	intermolecular recognition site; other site
447217003424	dimerization interface [polypeptide binding]; other site
447217003425	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
447217003426	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
447217003427	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217003428	CAAX protease self-immunity; Region: Abi; cl00558
447217003429	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
447217003430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217003431	Zn2+ binding site [ion binding]; other site
447217003432	Mg2+ binding site [ion binding]; other site
447217003433	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
447217003434	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
447217003435	putative dimer interface [polypeptide binding]; other site
447217003436	putative active site [active]
447217003437	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217003438	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
447217003439	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217003440	HSP70 interaction site [polypeptide binding]; other site
447217003441	Colicin V production protein; Region: Colicin_V; cl00567
447217003442	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217003443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003444	Walker A motif; other site
447217003445	ATP binding site [chemical binding]; other site
447217003446	Walker B motif; other site
447217003447	Arginase family; Region: Arginase; cl00306
447217003448	Predicted transcriptional regulator [Transcription]; Region: COG1959
447217003449	Helix-turn-helix domains; Region: HTH; cl00088
447217003450	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
447217003451	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217003452	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
447217003453	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217003454	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
447217003455	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217003456	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217003457	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
447217003458	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
447217003459	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
447217003460	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
447217003461	4Fe-4S binding domain; Region: Fer4; cl02805
447217003462	4Fe-4S binding domain; Region: Fer4; cl02805
447217003463	NADH dehydrogenase; Region: NADHdh; cl00469
447217003464	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
447217003465	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
447217003466	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
447217003467	NADH dehydrogenase subunit B; Provisional; Region: PRK14818
447217003468	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
447217003469	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
447217003470	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
447217003471	NADH dehydrogenase subunit B; Provisional; Region: PRK14817
447217003472	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
447217003473	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
447217003474	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
447217003475	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
447217003476	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
447217003477	catalytic loop [active]
447217003478	iron binding site [ion binding]; other site
447217003479	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
447217003480	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
447217003481	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217003482	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217003483	NADH dehydrogenase; Region: NADHdh; cl00469
447217003484	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
447217003485	4Fe-4S binding domain; Region: Fer4; cl02805
447217003486	muropeptide transporter; Validated; Region: ampG; PRK11010
447217003487	muropeptide transporter; Reviewed; Region: ampG; PRK11902
447217003488	hypothetical protein; Provisional; Region: PRK08609
447217003489	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
447217003490	active site
447217003491	primer binding site [nucleotide binding]; other site
447217003492	NTP  binding site [chemical binding]; other site
447217003493	metal binding triad [ion binding]; metal-binding site
447217003494	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
447217003495	MPT binding site; other site
447217003496	trimer interface [polypeptide binding]; other site
447217003497	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
447217003498	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
447217003499	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
447217003500	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
447217003501	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217003502	Double zinc ribbon; Region: DZR; pfam12773
447217003503	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
447217003504	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003505	phosphopeptide binding site; other site
447217003506	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003507	phosphopeptide binding site; other site
447217003508	Domain of unknown function DUF77; Region: DUF77; cl00307
447217003509	Double zinc ribbon; Region: DZR; pfam12773
447217003510	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217003511	phosphopeptide binding site; other site
447217003512	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
447217003513	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217003514	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
447217003515	synthetase active site [active]
447217003516	NTP binding site [chemical binding]; other site
447217003517	metal binding site [ion binding]; metal-binding site
447217003518	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
447217003519	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
447217003520	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
447217003521	homotrimer interaction site [polypeptide binding]; other site
447217003522	putative active site [active]
447217003523	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
447217003524	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217003525	FeS/SAM binding site; other site
447217003526	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
447217003527	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
447217003528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
447217003529	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
447217003530	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217003531	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217003532	Stage II sporulation protein; Region: SpoIID; pfam08486
447217003533	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
447217003534	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
447217003535	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
447217003536	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
447217003537	Preprotein translocase subunit; Region: YajC; cl00806
447217003538	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
447217003539	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
447217003540	Protein export membrane protein; Region: SecD_SecF; cl14618
447217003541	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
447217003542	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
447217003543	Protein export membrane protein; Region: SecD_SecF; cl14618
447217003544	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003546	active site
447217003547	phosphorylation site [posttranslational modification]
447217003548	intermolecular recognition site; other site
447217003549	dimerization interface [polypeptide binding]; other site
447217003550	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
447217003551	DHH family; Region: DHH; pfam01368
447217003552	DHHA1 domain; Region: DHHA1; pfam02272
447217003553	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
447217003554	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
447217003555	NADP binding site [chemical binding]; other site
447217003556	dimer interface [polypeptide binding]; other site
447217003557	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
447217003558	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
447217003559	dimer interface [polypeptide binding]; other site
447217003560	anticodon binding site; other site
447217003561	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
447217003562	homodimer interface [polypeptide binding]; other site
447217003563	motif 1; other site
447217003564	active site
447217003565	motif 2; other site
447217003566	GAD domain; Region: GAD; pfam02938
447217003567	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217003568	active site
447217003569	motif 3; other site
447217003570	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
447217003571	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
447217003572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003574	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217003575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003576	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
447217003577	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
447217003578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217003579	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217003580	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
447217003581	NHL repeat; Region: NHL; pfam01436
447217003582	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
447217003583	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
447217003584	RHS Repeat; Region: RHS_repeat; cl11982
447217003585	RHS Repeat; Region: RHS_repeat; cl11982
447217003586	RHS Repeat; Region: RHS_repeat; cl11982
447217003587	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217003588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
447217003589	Helix-turn-helix domains; Region: HTH; cl00088
447217003590	dimerization interface [polypeptide binding]; other site
447217003591	DNA binding residues [nucleotide binding]
447217003592	Integrase core domain; Region: rve; cl01316
447217003593	transposase/IS protein; Provisional; Region: PRK09183
447217003594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003595	Walker A motif; other site
447217003596	ATP binding site [chemical binding]; other site
447217003597	Walker B motif; other site
447217003598	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
447217003599	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217003600	ATP binding site [chemical binding]; other site
447217003601	putative Mg++ binding site [ion binding]; other site
447217003602	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217003603	nucleotide binding region [chemical binding]; other site
447217003604	ATP-binding site [chemical binding]; other site
447217003605	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217003606	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217003607	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217003608	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217003609	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217003610	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
447217003611	Ferritin-like domain; Region: Ferritin; pfam00210
447217003612	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
447217003613	dimerization interface [polypeptide binding]; other site
447217003614	DPS ferroxidase diiron center [ion binding]; other site
447217003615	ion pore; other site
447217003616	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
447217003617	thiS-thiF/thiG interaction site; other site
447217003618	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
447217003619	ThiS interaction site; other site
447217003620	putative active site [active]
447217003621	tetramer interface [polypeptide binding]; other site
447217003622	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
447217003623	active site
447217003624	thiamine phosphate binding site [chemical binding]; other site
447217003625	pyrophosphate binding site [ion binding]; other site
447217003626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217003627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217003628	S-adenosylmethionine binding site [chemical binding]; other site
447217003629	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
447217003630	active site
447217003631	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
447217003632	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
447217003633	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
447217003634	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
447217003635	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217003636	active site
447217003637	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
447217003638	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
447217003639	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
447217003640	putative active site; other site
447217003641	catalytic residue [active]
447217003642	Protein of unknown function (DUF507); Region: DUF507; cl01112
447217003643	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217003644	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217003645	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217003646	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
447217003647	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217003648	catalytic residue [active]
447217003649	Maf-like protein; Region: Maf; pfam02545
447217003650	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
447217003651	active site
447217003652	dimer interface [polypeptide binding]; other site
447217003653	SurA N-terminal domain; Region: SurA_N_3; cl07813
447217003654	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
447217003655	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217003656	rod shape-determining protein MreC; Region: MreC; pfam04085
447217003657	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
447217003658	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
447217003659	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217003660	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
447217003661	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217003662	catalytic residues [active]
447217003663	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217003664	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
447217003665	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
447217003666	tRNA; other site
447217003667	putative tRNA binding site [nucleotide binding]; other site
447217003668	putative NADP binding site [chemical binding]; other site
447217003669	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
447217003670	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
447217003671	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
447217003672	domain interfaces; other site
447217003673	active site
447217003674	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
447217003675	active site
447217003676	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
447217003677	Uncharacterized conserved protein [Function unknown]; Region: COG0585
447217003678	PSTD1: Pseudouridine synthase, a subgroup of the TruD family. This group consists of several hypothetical archeal pseudouridine synthases assigned to the TruD family of psuedouridine synthases.  Pseudouridine synthases catalyze the isomerization of...; Region: PSTD1; cd02577
447217003679	active site
447217003680	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
447217003681	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
447217003682	PHP-associated; Region: PHP_C; pfam13263
447217003683	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217003684	active site
447217003685	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
447217003686	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
447217003687	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
447217003688	active site
447217003689	effector binding site; other site
447217003690	dimer interface [polypeptide binding]; other site
447217003691	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
447217003692	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217003693	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217003694	putative dimer interface [polypeptide binding]; other site
447217003695	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
447217003696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003697	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
447217003698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003699	FAD dependent oxidoreductase; Region: DAO; pfam01266
447217003700	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
447217003701	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
447217003702	Sulfatase; Region: Sulfatase; cl10460
447217003703	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
447217003704	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217003705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003706	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217003707	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003708	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
447217003709	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217003710	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217003711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217003712	active site
447217003713	ATP binding site [chemical binding]; other site
447217003714	substrate binding site [chemical binding]; other site
447217003715	activation loop (A-loop); other site
447217003716	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217003717	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
447217003718	DNA binding residues [nucleotide binding]
447217003719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217003720	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
447217003721	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
447217003722	purine monophosphate binding site [chemical binding]; other site
447217003723	dimer interface [polypeptide binding]; other site
447217003724	putative catalytic residues [active]
447217003725	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
447217003726	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
447217003727	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
447217003728	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
447217003729	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217003730	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
447217003731	AIR carboxylase; Region: AIRC; cl00310
447217003732	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
447217003733	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
447217003734	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
447217003735	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
447217003736	O-Antigen ligase; Region: Wzy_C; cl04850
447217003737	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217003738	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
447217003739	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
447217003740	Walker A/P-loop; other site
447217003741	ATP binding site [chemical binding]; other site
447217003742	Q-loop/lid; other site
447217003743	ABC transporter signature motif; other site
447217003744	Walker B; other site
447217003745	D-loop; other site
447217003746	H-loop/switch region; other site
447217003747	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
447217003748	putative homodimer interface [polypeptide binding]; other site
447217003749	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217003750	active site
447217003751	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217003752	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
447217003753	DXD motif; other site
447217003754	N-glycosyltransferase; Provisional; Region: PRK11204
447217003755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003756	Bacterial sugar transferase; Region: Bac_transf; cl00939
447217003757	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
447217003758	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
447217003759	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
447217003760	dimer interface [polypeptide binding]; other site
447217003761	active site
447217003762	Schiff base residues; other site
447217003763	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
447217003764	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217003765	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
447217003766	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
447217003767	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217003768	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
447217003769	homodimer interface [polypeptide binding]; other site
447217003770	homotetramer interface [polypeptide binding]; other site
447217003771	active site pocket [active]
447217003772	cleavage site
447217003773	TPR repeat; Region: TPR_11; pfam13414
447217003774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217003775	binding surface
447217003776	TPR motif; other site
447217003777	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217003778	PemK-like protein; Region: PemK; cl00995
447217003779	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003781	active site
447217003782	phosphorylation site [posttranslational modification]
447217003783	intermolecular recognition site; other site
447217003784	dimerization interface [polypeptide binding]; other site
447217003785	Helix-turn-helix domains; Region: HTH; cl00088
447217003786	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
447217003787	dimerization interface [polypeptide binding]; other site
447217003788	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
447217003789	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
447217003790	TPP-binding site [chemical binding]; other site
447217003791	tetramer interface [polypeptide binding]; other site
447217003792	heterodimer interface [polypeptide binding]; other site
447217003793	phosphorylation loop region [posttranslational modification]
447217003794	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217003795	hypothetical protein; Provisional; Region: PRK07206
447217003796	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217003797	DNA binding residues [nucleotide binding]
447217003798	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
447217003799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003800	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
447217003801	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
447217003802	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217003803	non-specific DNA binding site [nucleotide binding]; other site
447217003804	salt bridge; other site
447217003805	sequence-specific DNA binding site [nucleotide binding]; other site
447217003806	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003807	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
447217003808	dimer interface [polypeptide binding]; other site
447217003809	putative functional site; other site
447217003810	putative MPT binding site; other site
447217003811	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
447217003812	ribonuclease R; Region: RNase_R; TIGR02063
447217003813	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217003814	RNB domain; Region: RNB; pfam00773
447217003815	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
447217003816	RNA binding site [nucleotide binding]; other site
447217003817	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
447217003818	FOG: CBS domain [General function prediction only]; Region: COG0517
447217003819	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
447217003820	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217003821	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
447217003822	Walker A/P-loop; other site
447217003823	ATP binding site [chemical binding]; other site
447217003824	Q-loop/lid; other site
447217003825	ABC transporter signature motif; other site
447217003826	Walker B; other site
447217003827	D-loop; other site
447217003828	H-loop/switch region; other site
447217003829	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217003830	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
447217003831	Walker A/P-loop; other site
447217003832	ATP binding site [chemical binding]; other site
447217003833	Q-loop/lid; other site
447217003834	ABC transporter signature motif; other site
447217003835	Walker B; other site
447217003836	D-loop; other site
447217003837	H-loop/switch region; other site
447217003838	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217003839	TM-ABC transporter signature motif; other site
447217003840	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217003841	TM-ABC transporter signature motif; other site
447217003842	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
447217003843	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
447217003844	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
447217003845	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217003846	Walker A/P-loop; other site
447217003847	ATP binding site [chemical binding]; other site
447217003848	Q-loop/lid; other site
447217003849	ABC transporter signature motif; other site
447217003850	Walker B; other site
447217003851	D-loop; other site
447217003852	H-loop/switch region; other site
447217003853	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
447217003854	Smr domain; Region: Smr; cl02619
447217003855	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217003856	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217003857	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
447217003858	NodB motif; other site
447217003859	putative active site [active]
447217003860	putative catalytic site [active]
447217003861	putative Zn binding site [ion binding]; other site
447217003862	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
447217003863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217003864	DNA binding residues [nucleotide binding]
447217003865	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
447217003866	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
447217003867	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
447217003868	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
447217003869	active site
447217003870	(T/H)XGH motif; other site
447217003871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003872	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
447217003873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003874	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217003875	Walker A motif; other site
447217003876	ATP binding site [chemical binding]; other site
447217003877	Walker B motif; other site
447217003878	arginine finger; other site
447217003879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217003880	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217003881	Walker A motif; other site
447217003882	ATP binding site [chemical binding]; other site
447217003883	Walker B motif; other site
447217003884	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217003885	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
447217003886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217003887	4Fe-4S binding domain; Region: Fer4; cl02805
447217003888	4Fe-4S binding domain; Region: Fer4; cl02805
447217003889	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217003890	iron-sulfur cluster [ion binding]; other site
447217003891	[2Fe-2S] cluster binding site [ion binding]; other site
447217003892	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217003893	interchain domain interface [polypeptide binding]; other site
447217003894	intrachain domain interface; other site
447217003895	heme bL binding site [chemical binding]; other site
447217003896	heme bH binding site [chemical binding]; other site
447217003897	Qo binding site; other site
447217003898	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
447217003899	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
447217003900	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
447217003901	nitrous-oxide reductase; Validated; Region: PRK02888
447217003902	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217003903	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
447217003904	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217003905	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
447217003906	Walker A/P-loop; other site
447217003907	ATP binding site [chemical binding]; other site
447217003908	Q-loop/lid; other site
447217003909	ABC transporter signature motif; other site
447217003910	Walker B; other site
447217003911	D-loop; other site
447217003912	H-loop/switch region; other site
447217003913	NosL; Region: NosL; cl01769
447217003914	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217003915	active site
447217003916	nucleophile elbow; other site
447217003917	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217003918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217003919	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217003920	TPR motif; other site
447217003921	binding surface
447217003922	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
447217003923	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
447217003924	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
447217003925	ring oligomerisation interface [polypeptide binding]; other site
447217003926	ATP/Mg binding site [chemical binding]; other site
447217003927	stacking interactions; other site
447217003928	hinge regions; other site
447217003929	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003931	active site
447217003932	phosphorylation site [posttranslational modification]
447217003933	intermolecular recognition site; other site
447217003934	dimerization interface [polypeptide binding]; other site
447217003935	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217003936	metal binding site [ion binding]; metal-binding site
447217003937	active site
447217003938	I-site; other site
447217003939	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217003940	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003942	active site
447217003943	phosphorylation site [posttranslational modification]
447217003944	intermolecular recognition site; other site
447217003945	dimerization interface [polypeptide binding]; other site
447217003946	valyl-tRNA synthetase; Provisional; Region: valS; PRK14900
447217003947	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
447217003948	HIGH motif; other site
447217003949	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
447217003950	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
447217003951	active site
447217003952	KMSKS motif; other site
447217003953	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
447217003954	tRNA binding surface [nucleotide binding]; other site
447217003955	anticodon binding site; other site
447217003956	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
447217003957	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
447217003958	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
447217003959	dimerization interface [polypeptide binding]; other site
447217003960	active site
447217003961	Helix-turn-helix domains; Region: HTH; cl00088
447217003962	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
447217003963	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
447217003964	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
447217003965	Type III pantothenate kinase; Region: Pan_kinase; cl09130
447217003966	integral membrane protein MviN; Region: mviN; TIGR01695
447217003967	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
447217003968	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
447217003969	Response regulator receiver domain; Region: Response_reg; pfam00072
447217003970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217003971	active site
447217003972	phosphorylation site [posttranslational modification]
447217003973	intermolecular recognition site; other site
447217003974	dimerization interface [polypeptide binding]; other site
447217003975	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217003976	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217003977	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217003978	DNA binding residues [nucleotide binding]
447217003979	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217003980	Radical SAM superfamily; Region: Radical_SAM; pfam04055
447217003981	FeS/SAM binding site; other site
447217003982	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
447217003983	PUA domain; Region: PUA; cl00607
447217003984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217003985	CAAX protease self-immunity; Region: Abi; cl00558
447217003986	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
447217003987	Flavoprotein; Region: Flavoprotein; cl08021
447217003988	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
447217003989	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
447217003990	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
447217003991	Fe-S cluster binding site [ion binding]; other site
447217003992	active site
447217003993	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
447217003994	active site residues [active]
447217003995	dimer interface [polypeptide binding]; other site
447217003996	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
447217003997	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
447217003998	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
447217003999	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
447217004000	catalytic nucleophile [active]
447217004001	putative acyltransferase; Provisional; Region: PRK05790
447217004002	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
447217004003	dimer interface [polypeptide binding]; other site
447217004004	active site
447217004005	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
447217004006	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
447217004007	Uncharacterized conserved protein [Function unknown]; Region: COG1912
447217004008	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
447217004009	PilZ domain; Region: PilZ; cl01260
447217004010	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
447217004011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217004012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217004013	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
447217004014	AMP-binding enzyme; Region: AMP-binding; cl15778
447217004015	AMP-binding enzyme; Region: AMP-binding; cl15778
447217004016	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217004017	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217004018	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
447217004019	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217004020	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217004021	Peptidase family M48; Region: Peptidase_M48; cl12018
447217004022	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
447217004023	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217004024	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
447217004025	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
447217004026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217004027	FeS/SAM binding site; other site
447217004028	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
447217004029	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
447217004030	trimer interface [polypeptide binding]; other site
447217004031	putative metal binding site [ion binding]; other site
447217004032	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217004033	ligand binding site [chemical binding]; other site
447217004034	flexible hinge region; other site
447217004035	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
447217004036	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217004037	PilZ domain; Region: PilZ; cl01260
447217004038	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217004039	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
447217004040	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
447217004041	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
447217004042	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
447217004043	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
447217004044	active site
447217004045	GMP synthase; Reviewed; Region: guaA; PRK00074
447217004046	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
447217004047	AMP/PPi binding site [chemical binding]; other site
447217004048	candidate oxyanion hole; other site
447217004049	catalytic triad [active]
447217004050	potential glutamine specificity residues [chemical binding]; other site
447217004051	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
447217004052	ATP Binding subdomain [chemical binding]; other site
447217004053	Ligand Binding sites [chemical binding]; other site
447217004054	Dimerization subdomain; other site
447217004055	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217004056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217004057	TPR motif; other site
447217004058	binding surface
447217004059	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217004060	AMP-binding enzyme; Region: AMP-binding; cl15778
447217004061	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004063	active site
447217004064	phosphorylation site [posttranslational modification]
447217004065	intermolecular recognition site; other site
447217004066	dimerization interface [polypeptide binding]; other site
447217004067	SCP-2 sterol transfer family; Region: SCP2; cl01225
447217004068	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
447217004069	CoA-transferase family III; Region: CoA_transf_3; pfam02515
447217004070	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
447217004071	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217004072	intersubunit interface [polypeptide binding]; other site
447217004073	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
447217004074	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217004075	Walker A/P-loop; other site
447217004076	ATP binding site [chemical binding]; other site
447217004077	Q-loop/lid; other site
447217004078	ABC transporter signature motif; other site
447217004079	Walker B; other site
447217004080	D-loop; other site
447217004081	H-loop/switch region; other site
447217004082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
447217004083	HsdM N-terminal domain; Region: HsdM_N; pfam12161
447217004084	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
447217004085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004086	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
447217004087	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
447217004088	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
447217004089	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
447217004090	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217004091	ATP binding site [chemical binding]; other site
447217004092	putative Mg++ binding site [ion binding]; other site
447217004093	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
447217004094	Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653
447217004095	SEC-C motif; Region: SEC-C; pfam02810
447217004096	Domain of unknown function (DUF932); Region: DUF932; cl12129
447217004097	Domain of unknown function (DUF932); Region: DUF932; cl12129
447217004098	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
447217004099	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
447217004100	Protein of unknown function (DUF554); Region: DUF554; cl00784
447217004101	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
447217004102	DNA-binding interface [nucleotide binding]; DNA binding site
447217004103	HTH-like domain; Region: HTH_21; pfam13276
447217004104	Integrase core domain; Region: rve; cl01316
447217004105	Integrase core domain; Region: rve_3; cl15866
447217004106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217004107	Helix-turn-helix domain; Region: HTH_18; pfam12833
447217004108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004109	NAD(P) binding site [chemical binding]; other site
447217004110	active site
447217004111	Predicted permease [General function prediction only]; Region: COG2985
447217004112	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
447217004113	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217004114	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217004115	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
447217004116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004117	binding surface
447217004118	TPR motif; other site
447217004119	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217004120	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
447217004121	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004122	active site
447217004123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004124	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217004125	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217004126	dimer interface [polypeptide binding]; other site
447217004127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004128	catalytic residue [active]
447217004129	aspartate aminotransferase; Provisional; Region: PRK06836
447217004130	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217004131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004132	homodimer interface [polypeptide binding]; other site
447217004133	catalytic residue [active]
447217004134	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217004135	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217004136	Moco binding site; other site
447217004137	metal coordination site [ion binding]; other site
447217004138	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
447217004139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004140	NAD(P) binding site [chemical binding]; other site
447217004141	active site
447217004142	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217004143	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217004144	lipoyl attachment site [posttranslational modification]; other site
447217004145	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
447217004146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004147	NAD(P) binding site [chemical binding]; other site
447217004148	active site
447217004149	Predicted dehydrogenase [General function prediction only]; Region: COG5322
447217004150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004151	NAD(P) binding pocket [chemical binding]; other site
447217004152	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
447217004153	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004154	molybdopterin cofactor binding site; other site
447217004155	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004156	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
447217004157	putative molybdopterin cofactor binding site; other site
447217004158	IncA protein; Region: IncA; pfam04156
447217004159	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
447217004160	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217004161	putative NAD(P) binding site [chemical binding]; other site
447217004162	Helix-turn-helix domains; Region: HTH; cl00088
447217004163	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
447217004164	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217004165	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
447217004166	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
447217004167	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217004168	active site
447217004169	metal binding site [ion binding]; metal-binding site
447217004170	DNA binding site [nucleotide binding]
447217004171	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217004172	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217004173	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
447217004174	putative hydrophobic ligand binding site [chemical binding]; other site
447217004175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217004176	Helix-turn-helix domains; Region: HTH; cl00088
447217004177	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004178	putative effector binding pocket; other site
447217004179	dimerization interface [polypeptide binding]; other site
447217004180	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
447217004181	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
447217004182	elongation factor G; Reviewed; Region: PRK12740
447217004183	G1 box; other site
447217004184	putative GEF interaction site [polypeptide binding]; other site
447217004185	GTP/Mg2+ binding site [chemical binding]; other site
447217004186	Switch I region; other site
447217004187	G2 box; other site
447217004188	G3 box; other site
447217004189	Switch II region; other site
447217004190	G4 box; other site
447217004191	G5 box; other site
447217004192	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
447217004193	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217004194	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785
447217004195	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
447217004196	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
447217004197	putative peptidoglycan binding site; other site
447217004198	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
447217004199	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217004200	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
447217004201	Moco binding site; other site
447217004202	metal coordination site [ion binding]; other site
447217004203	dimerization interface [polypeptide binding]; other site
447217004204	Cytochrome c; Region: Cytochrom_C; cl11414
447217004205	Cytochrome c; Region: Cytochrom_C; cl11414
447217004206	Predicted secreted protein [Function unknown]; Region: COG5501
447217004207	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
447217004208	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
447217004209	DsrE/DsrF-like family; Region: DrsE; cl00672
447217004210	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
447217004211	active site
447217004212	metal binding site [ion binding]; metal-binding site
447217004213	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
447217004214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217004215	Cytochrome c; Region: Cytochrom_C; cl11414
447217004216	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
447217004217	Cu(I) binding site [ion binding]; other site
447217004218	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
447217004219	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217004220	Cytochrome c; Region: Cytochrom_C; cl11414
447217004221	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
447217004222	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217004223	D-pathway; other site
447217004224	Low-spin heme binding site [chemical binding]; other site
447217004225	Putative water exit pathway; other site
447217004226	Binuclear center (active site) [active]
447217004227	K-pathway; other site
447217004228	Putative proton exit pathway; other site
447217004229	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
447217004230	Subunit I/III interface [polypeptide binding]; other site
447217004231	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
447217004232	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
447217004233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004234	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
447217004235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004236	S-adenosylmethionine binding site [chemical binding]; other site
447217004237	Cupin domain; Region: Cupin_2; cl09118
447217004238	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
447217004239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217004240	OsmC-like protein; Region: OsmC; cl00767
447217004241	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
447217004242	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217004243	tetramer interface [polypeptide binding]; other site
447217004244	active site
447217004245	Mg2+/Mn2+ binding site [ion binding]; other site
447217004246	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
447217004247	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
447217004248	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217004249	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
447217004250	Transposase domain (DUF772); Region: DUF772; cl15789
447217004251	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217004252	Transposase domain (DUF772); Region: DUF772; cl15789
447217004253	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
447217004254	putative oxidoreductase; Provisional; Region: PRK13984
447217004255	4Fe-4S binding domain; Region: Fer4; cl02805
447217004256	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
447217004257	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
447217004258	Predicted integral membrane protein [Function unknown]; Region: COG0392
447217004259	Uncharacterized conserved protein [Function unknown]; Region: COG2898
447217004260	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
447217004261	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
447217004262	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217004263	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217004264	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217004265	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217004266	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
447217004267	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217004268	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217004269	DNA binding residues [nucleotide binding]
447217004270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
447217004271	NMT1-like family; Region: NMT1_2; cl15260
447217004272	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
447217004273	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
447217004274	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
447217004275	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
447217004276	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
447217004277	tetrameric interface [polypeptide binding]; other site
447217004278	NAD binding site [chemical binding]; other site
447217004279	catalytic residues [active]
447217004280	DoxX; Region: DoxX; cl00976
447217004281	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217004282	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217004283	dimerization interface [polypeptide binding]; other site
447217004284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004285	dimer interface [polypeptide binding]; other site
447217004286	phosphorylation site [posttranslational modification]
447217004287	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
447217004288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004289	ATP binding site [chemical binding]; other site
447217004290	Mg2+ binding site [ion binding]; other site
447217004291	G-X-G motif; other site
447217004292	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004294	active site
447217004295	phosphorylation site [posttranslational modification]
447217004296	intermolecular recognition site; other site
447217004297	dimerization interface [polypeptide binding]; other site
447217004298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004299	Walker A motif; other site
447217004300	ATP binding site [chemical binding]; other site
447217004301	Walker B motif; other site
447217004302	arginine finger; other site
447217004303	Helix-turn-helix domains; Region: HTH; cl00088
447217004304	Outer membrane efflux protein; Region: OEP; pfam02321
447217004305	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217004306	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217004307	multidrug efflux protein; Reviewed; Region: PRK09579
447217004308	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
447217004309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
447217004310	DNA-binding site [nucleotide binding]; DNA binding site
447217004311	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217004312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004313	homodimer interface [polypeptide binding]; other site
447217004314	catalytic residue [active]
447217004315	Transcriptional activator [Transcription]; Region: ChrR; COG3806
447217004316	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217004317	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004318	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217004319	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004320	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217004321	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
447217004322	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004323	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217004324	Cupin domain; Region: Cupin_2; cl09118
447217004325	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217004326	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
447217004327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004328	S-adenosylmethionine binding site [chemical binding]; other site
447217004329	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
447217004330	malate dehydrogenase; Reviewed; Region: PRK06223
447217004331	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
447217004332	NAD(P) binding site [chemical binding]; other site
447217004333	dimer interface [polypeptide binding]; other site
447217004334	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217004335	substrate binding site [chemical binding]; other site
447217004336	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
447217004337	BNR repeat-like domain; Region: BNR_2; pfam13088
447217004338	Ubiquitin-like proteins; Region: UBQ; cl00155
447217004339	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217004340	tetramer interface [polypeptide binding]; other site
447217004341	active site
447217004342	Mg2+/Mn2+ binding site [ion binding]; other site
447217004343	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
447217004344	5'-3' exonuclease; Region: 53EXOc; smart00475
447217004345	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
447217004346	active site
447217004347	metal binding site 1 [ion binding]; metal-binding site
447217004348	putative 5' ssDNA interaction site; other site
447217004349	metal binding site 3; metal-binding site
447217004350	metal binding site 2 [ion binding]; metal-binding site
447217004351	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
447217004352	putative DNA binding site [nucleotide binding]; other site
447217004353	putative metal binding site [ion binding]; other site
447217004354	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
447217004355	Nitrogen regulatory protein P-II; Region: P-II; cl00412
447217004356	Nitrogen regulatory protein P-II; Region: P-II; smart00938
447217004357	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217004358	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217004359	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
447217004360	putative FMN binding site [chemical binding]; other site
447217004361	LysR family transcriptional regulator; Provisional; Region: PRK14997
447217004362	Helix-turn-helix domains; Region: HTH; cl00088
447217004363	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004364	putative effector binding pocket; other site
447217004365	dimerization interface [polypeptide binding]; other site
447217004366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217004367	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
447217004368	Helix-turn-helix domains; Region: HTH; cl00088
447217004369	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
447217004370	dimerization interface [polypeptide binding]; other site
447217004371	substrate binding pocket [chemical binding]; other site
447217004372	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
447217004373	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
447217004374	active site 1 [active]
447217004375	dimer interface [polypeptide binding]; other site
447217004376	hexamer interface [polypeptide binding]; other site
447217004377	active site 2 [active]
447217004378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004379	dimerization interface [polypeptide binding]; other site
447217004380	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004381	dimer interface [polypeptide binding]; other site
447217004382	phosphorylation site [posttranslational modification]
447217004383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004384	ATP binding site [chemical binding]; other site
447217004385	Mg2+ binding site [ion binding]; other site
447217004386	G-X-G motif; other site
447217004387	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004389	active site
447217004390	phosphorylation site [posttranslational modification]
447217004391	intermolecular recognition site; other site
447217004392	dimerization interface [polypeptide binding]; other site
447217004393	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
447217004394	NMT1-like family; Region: NMT1_2; cl15260
447217004395	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217004396	TIGR03440 family protein; Region: unchr_TIGR03440
447217004397	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
447217004398	mercuric reductase; Validated; Region: PRK06370
447217004399	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217004400	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217004401	Pirin-related protein [General function prediction only]; Region: COG1741
447217004402	Cupin domain; Region: Cupin_2; cl09118
447217004403	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
447217004404	EamA-like transporter family; Region: EamA; cl01037
447217004405	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
447217004406	dimerization interface [polypeptide binding]; other site
447217004407	putative effector binding pocket; other site
447217004408	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217004409	catalytic residues [active]
447217004410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217004412	putative active site [active]
447217004413	heme pocket [chemical binding]; other site
447217004414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004415	dimer interface [polypeptide binding]; other site
447217004416	phosphorylation site [posttranslational modification]
447217004417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004418	ATP binding site [chemical binding]; other site
447217004419	Mg2+ binding site [ion binding]; other site
447217004420	G-X-G motif; other site
447217004421	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004423	active site
447217004424	phosphorylation site [posttranslational modification]
447217004425	intermolecular recognition site; other site
447217004426	dimerization interface [polypeptide binding]; other site
447217004427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004428	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004429	active site
447217004430	FOG: CBS domain [General function prediction only]; Region: COG0517
447217004431	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
447217004432	Helix-turn-helix domains; Region: HTH; cl00088
447217004433	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
447217004434	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
447217004435	putative dimerization interface [polypeptide binding]; other site
447217004436	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
447217004437	ATP binding site [chemical binding]; other site
447217004438	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217004439	ResB-like family; Region: ResB; pfam05140
447217004440	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217004441	Rubrerythrin [Energy production and conversion]; Region: COG1592
447217004442	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217004443	binuclear metal center [ion binding]; other site
447217004444	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
447217004445	iron binding site [ion binding]; other site
447217004446	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004447	PAS fold; Region: PAS_3; pfam08447
447217004448	putative active site [active]
447217004449	heme pocket [chemical binding]; other site
447217004450	PAS fold; Region: PAS_3; pfam08447
447217004451	GAF domain; Region: GAF; cl15785
447217004452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217004453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004454	dimer interface [polypeptide binding]; other site
447217004455	phosphorylation site [posttranslational modification]
447217004456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004457	ATP binding site [chemical binding]; other site
447217004458	Mg2+ binding site [ion binding]; other site
447217004459	G-X-G motif; other site
447217004460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004461	Response regulator receiver domain; Region: Response_reg; pfam00072
447217004462	active site
447217004463	phosphorylation site [posttranslational modification]
447217004464	intermolecular recognition site; other site
447217004465	dimerization interface [polypeptide binding]; other site
447217004466	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217004467	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217004468	DNA binding residues [nucleotide binding]
447217004469	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217004470	active site 2 [active]
447217004471	active site 1 [active]
447217004472	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
447217004473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004474	dimerization interface [polypeptide binding]; other site
447217004475	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217004476	dimer interface [polypeptide binding]; other site
447217004477	putative CheW interface [polypeptide binding]; other site
447217004478	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217004479	Nitrogen fixation protein NifW; Region: NifW; cl03935
447217004480	Transcriptional regulator; Region: Transcrip_reg; cl00361
447217004481	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217004482	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
447217004483	Walker A/P-loop; other site
447217004484	ATP binding site [chemical binding]; other site
447217004485	Q-loop/lid; other site
447217004486	ABC transporter signature motif; other site
447217004487	Walker B; other site
447217004488	D-loop; other site
447217004489	H-loop/switch region; other site
447217004490	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217004491	TM-ABC transporter signature motif; other site
447217004492	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217004493	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
447217004494	Walker A/P-loop; other site
447217004495	ATP binding site [chemical binding]; other site
447217004496	Q-loop/lid; other site
447217004497	ABC transporter signature motif; other site
447217004498	Walker B; other site
447217004499	D-loop; other site
447217004500	H-loop/switch region; other site
447217004501	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217004502	TM-ABC transporter signature motif; other site
447217004503	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
447217004504	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
447217004505	putative ligand binding site [chemical binding]; other site
447217004506	PilZ domain; Region: PilZ; cl01260
447217004507	NMT1-like family; Region: NMT1_2; cl15260
447217004508	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
447217004509	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
447217004510	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
447217004511	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
447217004512	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
447217004513	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
447217004514	[4Fe-4S] binding site [ion binding]; other site
447217004515	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004516	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004517	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004518	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
447217004519	molybdopterin cofactor binding site; other site
447217004520	PAS domain S-box; Region: sensory_box; TIGR00229
447217004521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217004522	putative active site [active]
447217004523	heme pocket [chemical binding]; other site
447217004524	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217004525	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
447217004526	putative acyl-acceptor binding pocket; other site
447217004527	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217004528	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
447217004529	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
447217004530	Transposase IS200 like; Region: Y1_Tnp; cl00848
447217004531	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217004532	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
447217004533	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
447217004534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004535	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
447217004536	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217004537	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217004538	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217004539	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217004540	ABC transporter; Region: ABC_tran_2; pfam12848
447217004541	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217004542	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
447217004543	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
447217004544	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217004545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004546	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
447217004547	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004549	active site
447217004550	phosphorylation site [posttranslational modification]
447217004551	intermolecular recognition site; other site
447217004552	dimerization interface [polypeptide binding]; other site
447217004553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004554	Walker A motif; other site
447217004555	ATP binding site [chemical binding]; other site
447217004556	Walker B motif; other site
447217004557	arginine finger; other site
447217004558	Helix-turn-helix domains; Region: HTH; cl00088
447217004559	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217004560	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217004561	substrate binding pocket [chemical binding]; other site
447217004562	membrane-bound complex binding site; other site
447217004563	hinge residues; other site
447217004564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217004565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004566	ATP binding site [chemical binding]; other site
447217004567	Mg2+ binding site [ion binding]; other site
447217004568	G-X-G motif; other site
447217004569	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
447217004570	putative deacylase active site [active]
447217004571	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
447217004572	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217004573	catalytic residues [active]
447217004574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217004575	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217004576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217004577	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
447217004578	active site
447217004579	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
447217004580	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217004581	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
447217004582	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
447217004583	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217004584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004585	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217004586	Walker A motif; other site
447217004587	ATP binding site [chemical binding]; other site
447217004588	Walker B motif; other site
447217004589	Helix-turn-helix domains; Region: HTH; cl00088
447217004590	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
447217004591	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217004592	E3 interaction surface; other site
447217004593	lipoyl attachment site [posttranslational modification]; other site
447217004594	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217004595	E3 interaction surface; other site
447217004596	lipoyl attachment site [posttranslational modification]; other site
447217004597	e3 binding domain; Region: E3_binding; pfam02817
447217004598	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
447217004599	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
447217004600	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
447217004601	dimer interface [polypeptide binding]; other site
447217004602	TPP-binding site [chemical binding]; other site
447217004603	Kelch motif; Region: Kelch_1; cl02701
447217004604	Kelch motif; Region: Kelch_1; cl02701
447217004605	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217004606	active site
447217004607	ATP binding site [chemical binding]; other site
447217004608	substrate binding site [chemical binding]; other site
447217004609	activation loop (A-loop); other site
447217004610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004611	TPR motif; other site
447217004612	binding surface
447217004613	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217004614	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217004615	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217004616	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217004617	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217004618	active site
447217004619	catalytic tetrad [active]
447217004620	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217004621	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217004622	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217004623	active site
447217004624	metal binding site [ion binding]; metal-binding site
447217004625	Putative exonuclease, RdgC; Region: RdgC; cl01122
447217004626	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217004627	active site
447217004628	Helix-turn-helix domains; Region: HTH; cl00088
447217004629	Helix-turn-helix domains; Region: HTH; cl00088
447217004630	Integrase core domain; Region: rve; cl01316
447217004631	Integrase core domain; Region: rve_3; cl15866
447217004632	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217004633	G1 box; other site
447217004634	GTP/Mg2+ binding site [chemical binding]; other site
447217004635	G2 box; other site
447217004636	Switch I region; other site
447217004637	G3 box; other site
447217004638	Switch II region; other site
447217004639	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217004640	G4 box; other site
447217004641	G5 box; other site
447217004642	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
447217004643	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
447217004644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217004645	Coenzyme A binding pocket [chemical binding]; other site
447217004646	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
447217004647	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
447217004648	G1 box; other site
447217004649	putative GEF interaction site [polypeptide binding]; other site
447217004650	GTP/Mg2+ binding site [chemical binding]; other site
447217004651	Switch I region; other site
447217004652	G2 box; other site
447217004653	G3 box; other site
447217004654	Switch II region; other site
447217004655	G4 box; other site
447217004656	G5 box; other site
447217004657	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
447217004658	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217004659	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
447217004660	dimer interface [polypeptide binding]; other site
447217004661	active site
447217004662	metal binding site [ion binding]; metal-binding site
447217004663	glutathione binding site [chemical binding]; other site
447217004664	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217004665	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
447217004666	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
447217004667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004668	NeuB family; Region: NeuB; cl00496
447217004669	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
447217004670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217004671	S-adenosylmethionine binding site [chemical binding]; other site
447217004672	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
447217004673	Cation efflux family; Region: Cation_efflux; cl00316
447217004674	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
447217004675	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
447217004676	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217004677	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217004678	substrate binding pocket [chemical binding]; other site
447217004679	membrane-bound complex binding site; other site
447217004680	hinge residues; other site
447217004681	sensory histidine kinase AtoS; Provisional; Region: PRK11360
447217004682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004683	ATP binding site [chemical binding]; other site
447217004684	Mg2+ binding site [ion binding]; other site
447217004685	G-X-G motif; other site
447217004686	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004688	active site
447217004689	phosphorylation site [posttranslational modification]
447217004690	intermolecular recognition site; other site
447217004691	dimerization interface [polypeptide binding]; other site
447217004692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004693	Walker A motif; other site
447217004694	ATP binding site [chemical binding]; other site
447217004695	Walker B motif; other site
447217004696	arginine finger; other site
447217004697	Helix-turn-helix domains; Region: HTH; cl00088
447217004698	Transposase domain (DUF772); Region: DUF772; cl15789
447217004699	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217004700	Transposase domain (DUF772); Region: DUF772; cl15789
447217004701	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
447217004702	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
447217004703	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217004704	active site
447217004705	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
447217004706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004707	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004708	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
447217004709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004710	NAD(P) binding site [chemical binding]; other site
447217004711	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
447217004712	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
447217004713	substrate-cofactor binding pocket; other site
447217004714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217004715	catalytic residue [active]
447217004716	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217004717	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
447217004718	ATP binding site [chemical binding]; other site
447217004719	putative Mg++ binding site [ion binding]; other site
447217004720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217004721	nucleotide binding region [chemical binding]; other site
447217004722	ATP-binding site [chemical binding]; other site
447217004723	DEAD/H associated; Region: DEAD_assoc; pfam08494
447217004724	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
447217004725	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
447217004726	DNA binding site [nucleotide binding]
447217004727	catalytic residue [active]
447217004728	H2TH interface [polypeptide binding]; other site
447217004729	putative catalytic residues [active]
447217004730	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217004731	CHASE domain; Region: CHASE; cl01369
447217004732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004733	dimer interface [polypeptide binding]; other site
447217004734	phosphorylation site [posttranslational modification]
447217004735	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
447217004736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004737	ATP binding site [chemical binding]; other site
447217004738	Mg2+ binding site [ion binding]; other site
447217004739	G-X-G motif; other site
447217004740	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217004741	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004742	molybdopterin cofactor binding site; other site
447217004743	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004744	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217004745	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217004746	molybdopterin cofactor binding site; other site
447217004747	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
447217004748	4Fe-4S binding domain; Region: Fer4; cl02805
447217004749	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217004750	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
447217004751	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
447217004752	active site
447217004753	ADP/pyrophosphate binding site [chemical binding]; other site
447217004754	dimerization interface [polypeptide binding]; other site
447217004755	allosteric effector site; other site
447217004756	fructose-1,6-bisphosphate binding site; other site
447217004757	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
447217004758	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217004759	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217004760	catalytic residue [active]
447217004761	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217004762	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
447217004763	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
447217004764	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
447217004765	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
447217004766	metal binding site [ion binding]; metal-binding site
447217004767	dimer interface [polypeptide binding]; other site
447217004768	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217004769	putative acyl-acceptor binding pocket; other site
447217004770	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
447217004771	RNA/DNA hybrid binding site [nucleotide binding]; other site
447217004772	active site
447217004773	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217004774	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217004775	active site
447217004776	catalytic tetrad [active]
447217004777	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
447217004778	diiron binding motif [ion binding]; other site
447217004779	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
447217004780	Protein of unknown function (DUF541); Region: SIMPL; cl01077
447217004781	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
447217004782	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
447217004783	active site
447217004784	catalytic residues [active]
447217004785	metal binding site [ion binding]; metal-binding site
447217004786	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
447217004787	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
447217004788	tartrate dehydrogenase; Provisional; Region: PRK08194
447217004789	OpgC protein; Region: OpgC_C; cl00792
447217004790	fumarate hydratase; Provisional; Region: PRK15389
447217004791	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
447217004792	Fumarase C-terminus; Region: Fumerase_C; cl00795
447217004793	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
447217004794	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
447217004795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
447217004796	TolB amino-terminal domain; Region: TolB_N; cl00639
447217004797	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
447217004798	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
447217004799	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217004800	Walker A/P-loop; other site
447217004801	ATP binding site [chemical binding]; other site
447217004802	Q-loop/lid; other site
447217004803	ABC transporter signature motif; other site
447217004804	Walker B; other site
447217004805	D-loop; other site
447217004806	H-loop/switch region; other site
447217004807	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217004808	elongation factor G; Reviewed; Region: PRK12739
447217004809	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217004810	G1 box; other site
447217004811	GTP/Mg2+ binding site [chemical binding]; other site
447217004812	G2 box; other site
447217004813	Switch I region; other site
447217004814	G3 box; other site
447217004815	Switch II region; other site
447217004816	G4 box; other site
447217004817	G5 box; other site
447217004818	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217004819	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
447217004820	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217004821	DTW domain; Region: DTW; cl01221
447217004822	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
447217004823	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217004824	putative active site [active]
447217004825	catalytic site [active]
447217004826	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
447217004827	putative active site [active]
447217004828	catalytic site [active]
447217004829	oligoendopeptidase F; Region: pepF; TIGR00181
447217004830	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
447217004831	active site
447217004832	Zn binding site [ion binding]; other site
447217004833	AsmA-like C-terminal region; Region: AsmA_2; cl15864
447217004834	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
447217004835	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217004836	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
447217004837	dimer interface [polypeptide binding]; other site
447217004838	substrate binding site [chemical binding]; other site
447217004839	ATP binding site [chemical binding]; other site
447217004840	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
447217004841	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
447217004842	MarC family integral membrane protein; Region: MarC; cl00919
447217004843	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
447217004844	active site
447217004845	catalytic triad [active]
447217004846	oxyanion hole [active]
447217004847	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
447217004848	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217004849	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217004850	Walker A/P-loop; other site
447217004851	ATP binding site [chemical binding]; other site
447217004852	Q-loop/lid; other site
447217004853	ABC transporter signature motif; other site
447217004854	Walker B; other site
447217004855	D-loop; other site
447217004856	H-loop/switch region; other site
447217004857	FtsX-like permease family; Region: FtsX; cl15850
447217004858	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
447217004859	HDOD domain; Region: HDOD; pfam08668
447217004860	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217004861	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891
447217004862	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
447217004863	Bacterial Ig-like domain; Region: Big_5; cl01012
447217004864	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
447217004865	MG2 domain; Region: A2M_N; pfam01835
447217004866	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
447217004867	Alpha-2-macroglobulin family; Region: A2M; pfam00207
447217004868	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
447217004869	surface patch; other site
447217004870	thioester region; other site
447217004871	specificity defining residues; other site
447217004872	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
447217004873	Transglycosylase; Region: Transgly; cl07896
447217004874	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217004875	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217004876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004877	binding surface
447217004878	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217004879	TPR motif; other site
447217004880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217004881	TPR motif; other site
447217004882	binding surface
447217004883	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
447217004884	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
447217004885	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217004886	DXD motif; other site
447217004887	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
447217004888	phosphoglucomutase; Validated; Region: PRK07564
447217004889	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
447217004890	active site
447217004891	substrate binding site [chemical binding]; other site
447217004892	metal binding site [ion binding]; metal-binding site
447217004893	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217004894	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
447217004895	active site
447217004896	catalytic tetrad [active]
447217004897	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217004898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004899	NAD(P) binding site [chemical binding]; other site
447217004900	active site
447217004901	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
447217004902	Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401
447217004903	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
447217004904	active site
447217004905	Zn binding site [ion binding]; other site
447217004906	CsbD-like; Region: CsbD; cl15799
447217004907	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
447217004908	Protein export membrane protein; Region: SecD_SecF; cl14618
447217004909	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217004910	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217004911	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217004912	Outer membrane efflux protein; Region: OEP; pfam02321
447217004913	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
447217004914	GSH binding site [chemical binding]; other site
447217004915	catalytic residues [active]
447217004916	Peptidase family M48; Region: Peptidase_M48; cl12018
447217004917	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
447217004918	Helix-turn-helix domains; Region: HTH; cl00088
447217004919	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
447217004920	putative dimerization interface [polypeptide binding]; other site
447217004921	Integral membrane protein TerC family; Region: TerC; cl10468
447217004922	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
447217004923	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
447217004924	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
447217004925	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
447217004926	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
447217004927	putative active site [active]
447217004928	putative substrate binding site [chemical binding]; other site
447217004929	putative cosubstrate binding site; other site
447217004930	catalytic site [active]
447217004931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217004932	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004933	dimerization interface [polypeptide binding]; other site
447217004934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004935	dimer interface [polypeptide binding]; other site
447217004936	phosphorylation site [posttranslational modification]
447217004937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004938	ATP binding site [chemical binding]; other site
447217004939	Mg2+ binding site [ion binding]; other site
447217004940	G-X-G motif; other site
447217004941	Peptidase family M54; Region: Peptidase_M54; cl00835
447217004942	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004944	active site
447217004945	phosphorylation site [posttranslational modification]
447217004946	intermolecular recognition site; other site
447217004947	dimerization interface [polypeptide binding]; other site
447217004948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217004949	Walker A motif; other site
447217004950	ATP binding site [chemical binding]; other site
447217004951	Walker B motif; other site
447217004952	arginine finger; other site
447217004953	Helix-turn-helix domains; Region: HTH; cl00088
447217004954	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
447217004955	4Fe-4S binding domain; Region: Fer4; cl02805
447217004956	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217004957	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217004958	lipoyl attachment site [posttranslational modification]; other site
447217004959	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217004960	lipoyl attachment site [posttranslational modification]; other site
447217004961	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
447217004962	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217004963	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217004964	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217004965	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217004966	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217004967	Peptidase family M48; Region: Peptidase_M48; cl12018
447217004968	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217004969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
447217004970	Histidine kinase; Region: HisKA_3; pfam07730
447217004971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004972	ATP binding site [chemical binding]; other site
447217004973	Mg2+ binding site [ion binding]; other site
447217004974	G-X-G motif; other site
447217004975	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217004976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004977	active site
447217004978	phosphorylation site [posttranslational modification]
447217004979	intermolecular recognition site; other site
447217004980	dimerization interface [polypeptide binding]; other site
447217004981	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217004982	DNA binding residues [nucleotide binding]
447217004983	dimerization interface [polypeptide binding]; other site
447217004984	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
447217004985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217004986	NAD(P) binding pocket [chemical binding]; other site
447217004987	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
447217004988	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217004989	dimerization interface [polypeptide binding]; other site
447217004990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217004991	dimer interface [polypeptide binding]; other site
447217004992	phosphorylation site [posttranslational modification]
447217004993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217004994	ATP binding site [chemical binding]; other site
447217004995	Mg2+ binding site [ion binding]; other site
447217004996	G-X-G motif; other site
447217004997	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217004998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217004999	active site
447217005000	phosphorylation site [posttranslational modification]
447217005001	intermolecular recognition site; other site
447217005002	dimerization interface [polypeptide binding]; other site
447217005003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005004	Walker A motif; other site
447217005005	ATP binding site [chemical binding]; other site
447217005006	Walker B motif; other site
447217005007	arginine finger; other site
447217005008	Helix-turn-helix domains; Region: HTH; cl00088
447217005009	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
447217005010	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217005011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217005012	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217005013	DNA binding residues [nucleotide binding]
447217005014	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005016	dimer interface [polypeptide binding]; other site
447217005017	phosphorylation site [posttranslational modification]
447217005018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005019	active site
447217005020	phosphorylation site [posttranslational modification]
447217005021	intermolecular recognition site; other site
447217005022	dimerization interface [polypeptide binding]; other site
447217005023	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
447217005024	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
447217005025	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
447217005026	G1 box; other site
447217005027	putative GEF interaction site [polypeptide binding]; other site
447217005028	GTP/Mg2+ binding site [chemical binding]; other site
447217005029	Switch I region; other site
447217005030	G2 box; other site
447217005031	G3 box; other site
447217005032	Switch II region; other site
447217005033	G4 box; other site
447217005034	G5 box; other site
447217005035	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
447217005036	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
447217005037	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217005038	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217005039	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
447217005040	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217005041	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217005042	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
447217005043	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
447217005044	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
447217005045	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
447217005046	active site
447217005047	dimer interface [polypeptide binding]; other site
447217005048	motif 1; other site
447217005049	motif 2; other site
447217005050	motif 3; other site
447217005051	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
447217005052	anticodon binding site; other site
447217005053	2-isopropylmalate synthase; Validated; Region: PRK00915
447217005054	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
447217005055	active site
447217005056	catalytic residues [active]
447217005057	metal binding site [ion binding]; metal-binding site
447217005058	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
447217005059	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
447217005060	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
447217005061	substrate binding site [chemical binding]; other site
447217005062	ligand binding site [chemical binding]; other site
447217005063	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
447217005064	substrate binding site [chemical binding]; other site
447217005065	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
447217005066	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
447217005067	PYR/PP interface [polypeptide binding]; other site
447217005068	dimer interface [polypeptide binding]; other site
447217005069	TPP binding site [chemical binding]; other site
447217005070	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
447217005071	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
447217005072	TPP-binding site [chemical binding]; other site
447217005073	dimer interface [polypeptide binding]; other site
447217005074	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
447217005075	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
447217005076	putative valine binding site [chemical binding]; other site
447217005077	dimer interface [polypeptide binding]; other site
447217005078	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
447217005079	ketol-acid reductoisomerase; Provisional; Region: PRK05479
447217005080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005081	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
447217005082	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
447217005083	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
447217005084	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
447217005085	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
447217005086	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
447217005087	23S rRNA binding site [nucleotide binding]; other site
447217005088	L21 binding site [polypeptide binding]; other site
447217005089	L13 binding site [polypeptide binding]; other site
447217005090	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
447217005091	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
447217005092	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
447217005093	dimer interface [polypeptide binding]; other site
447217005094	motif 1; other site
447217005095	active site
447217005096	motif 2; other site
447217005097	motif 3; other site
447217005098	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
447217005099	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
447217005100	putative tRNA-binding site [nucleotide binding]; other site
447217005101	B3/4 domain; Region: B3_4; cl11458
447217005102	tRNA synthetase B5 domain; Region: B5; cl08394
447217005103	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217005104	active site
447217005105	dimer interface [polypeptide binding]; other site
447217005106	motif 2; other site
447217005107	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
447217005108	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217005109	IHF dimer interface [polypeptide binding]; other site
447217005110	IHF - DNA interface [nucleotide binding]; other site
447217005111	Helix-turn-helix domains; Region: HTH; cl00088
447217005112	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217005113	iron-sulfur cluster [ion binding]; other site
447217005114	[2Fe-2S] cluster binding site [ion binding]; other site
447217005115	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
447217005116	active site
447217005117	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
447217005118	active site
447217005119	classical (c) SDRs; Region: SDR_c; cd05233
447217005120	NAD(P) binding site [chemical binding]; other site
447217005121	active site
447217005122	FAD binding domain; Region: FAD_binding_4; pfam01565
447217005123	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
447217005124	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
447217005125	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
447217005126	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217005127	dimer interface [polypeptide binding]; other site
447217005128	PYR/PP interface [polypeptide binding]; other site
447217005129	TPP binding site [chemical binding]; other site
447217005130	substrate binding site [chemical binding]; other site
447217005131	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
447217005132	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217005133	TPP-binding site [chemical binding]; other site
447217005134	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
447217005135	4Fe-4S binding domain; Region: Fer4; cl02805
447217005136	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
447217005137	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217005138	dimer interface [polypeptide binding]; other site
447217005139	PYR/PP interface [polypeptide binding]; other site
447217005140	TPP binding site [chemical binding]; other site
447217005141	substrate binding site [chemical binding]; other site
447217005142	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
447217005143	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217005144	TPP-binding site [chemical binding]; other site
447217005145	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
447217005146	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217005147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217005148	TPR repeat; Region: TPR_11; pfam13414
447217005149	binding surface
447217005150	TPR motif; other site
447217005151	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
447217005152	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
447217005153	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217005154	NAD binding site [chemical binding]; other site
447217005155	putative substrate binding site 2 [chemical binding]; other site
447217005156	putative substrate binding site 1 [chemical binding]; other site
447217005157	active site
447217005158	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217005159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005160	NAD(P) binding site [chemical binding]; other site
447217005161	active site
447217005162	Transglycosylase; Region: Transgly; cl07896
447217005163	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
447217005164	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217005165	endonuclease III; Region: ENDO3c; smart00478
447217005166	minor groove reading motif; other site
447217005167	helix-hairpin-helix signature motif; other site
447217005168	substrate binding pocket [chemical binding]; other site
447217005169	active site
447217005170	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
447217005171	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
447217005172	S17 interaction site [polypeptide binding]; other site
447217005173	S8 interaction site; other site
447217005174	16S rRNA interaction site [nucleotide binding]; other site
447217005175	streptomycin interaction site [chemical binding]; other site
447217005176	23S rRNA interaction site [nucleotide binding]; other site
447217005177	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
447217005178	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
447217005179	elongation factor G; Reviewed; Region: PRK00007
447217005180	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
447217005181	G1 box; other site
447217005182	putative GEF interaction site [polypeptide binding]; other site
447217005183	GTP/Mg2+ binding site [chemical binding]; other site
447217005184	Switch I region; other site
447217005185	G2 box; other site
447217005186	G3 box; other site
447217005187	Switch II region; other site
447217005188	G4 box; other site
447217005189	G5 box; other site
447217005190	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217005191	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217005192	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217005193	elongation factor Tu; Reviewed; Region: PRK00049
447217005194	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
447217005195	G1 box; other site
447217005196	GEF interaction site [polypeptide binding]; other site
447217005197	GTP/Mg2+ binding site [chemical binding]; other site
447217005198	Switch I region; other site
447217005199	G2 box; other site
447217005200	G3 box; other site
447217005201	Switch II region; other site
447217005202	G4 box; other site
447217005203	G5 box; other site
447217005204	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
447217005205	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
447217005206	Antibiotic Binding Site [chemical binding]; other site
447217005207	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
447217005208	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
447217005209	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
447217005210	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
447217005211	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
447217005212	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
447217005213	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
447217005214	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
447217005215	protein-rRNA interface [nucleotide binding]; other site
447217005216	putative translocon binding site; other site
447217005217	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
447217005218	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
447217005219	G-X-X-G motif; other site
447217005220	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
447217005221	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
447217005222	23S rRNA interface [nucleotide binding]; other site
447217005223	5S rRNA interface [nucleotide binding]; other site
447217005224	putative antibiotic binding site [chemical binding]; other site
447217005225	L25 interface [polypeptide binding]; other site
447217005226	L27 interface [polypeptide binding]; other site
447217005227	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
447217005228	23S rRNA interface [nucleotide binding]; other site
447217005229	putative translocon interaction site; other site
447217005230	signal recognition particle (SRP54) interaction site; other site
447217005231	L23 interface [polypeptide binding]; other site
447217005232	trigger factor interaction site; other site
447217005233	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
447217005234	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
447217005235	KOW motif; Region: KOW; cl00354
447217005236	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
447217005237	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
447217005238	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
447217005239	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
447217005240	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
447217005241	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
447217005242	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
447217005243	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
447217005244	5S rRNA interface [nucleotide binding]; other site
447217005245	L27 interface [polypeptide binding]; other site
447217005246	L5 interface [polypeptide binding]; other site
447217005247	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
447217005248	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
447217005249	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
447217005250	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
447217005251	23S rRNA binding site [nucleotide binding]; other site
447217005252	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
447217005253	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
447217005254	SecY translocase; Region: SecY; pfam00344
447217005255	adenylate kinase; Reviewed; Region: adk; PRK00279
447217005256	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
447217005257	AMP-binding site [chemical binding]; other site
447217005258	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
447217005259	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217005260	active site
447217005261	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
447217005262	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
447217005263	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
447217005264	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
447217005265	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
447217005266	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
447217005267	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217005268	RNA binding surface [nucleotide binding]; other site
447217005269	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
447217005270	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
447217005271	alphaNTD homodimer interface [polypeptide binding]; other site
447217005272	alphaNTD - beta interaction site [polypeptide binding]; other site
447217005273	alphaNTD - beta' interaction site [polypeptide binding]; other site
447217005274	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
447217005275	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
447217005276	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
447217005277	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
447217005278	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
447217005279	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
447217005280	RimM N-terminal domain; Region: RimM; pfam01782
447217005281	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
447217005282	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
447217005283	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
447217005284	Restriction endonuclease; Region: Mrr_cat; cl00516
447217005285	Predicted methyltransferases [General function prediction only]; Region: COG0313
447217005286	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005288	active site
447217005289	phosphorylation site [posttranslational modification]
447217005290	intermolecular recognition site; other site
447217005291	dimerization interface [polypeptide binding]; other site
447217005292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005293	Walker A motif; other site
447217005294	ATP binding site [chemical binding]; other site
447217005295	Walker B motif; other site
447217005296	arginine finger; other site
447217005297	Helix-turn-helix domains; Region: HTH; cl00088
447217005298	GAF domain; Region: GAF; cl15785
447217005299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005301	dimer interface [polypeptide binding]; other site
447217005302	phosphorylation site [posttranslational modification]
447217005303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005304	ATP binding site [chemical binding]; other site
447217005305	Mg2+ binding site [ion binding]; other site
447217005306	G-X-G motif; other site
447217005307	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217005308	murein transglycosylase C; Provisional; Region: mltC; PRK11671
447217005309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
447217005310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217005311	catalytic residue [active]
447217005312	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217005313	active site
447217005314	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
447217005315	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
447217005316	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
447217005317	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217005318	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217005319	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217005320	RNA binding surface [nucleotide binding]; other site
447217005321	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217005322	active site
447217005323	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217005324	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217005325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217005326	binding surface
447217005327	TPR motif; other site
447217005328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217005329	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217005330	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217005331	Walker A/P-loop; other site
447217005332	ATP binding site [chemical binding]; other site
447217005333	Q-loop/lid; other site
447217005334	ABC transporter signature motif; other site
447217005335	Walker B; other site
447217005336	D-loop; other site
447217005337	H-loop/switch region; other site
447217005338	arginine decarboxylase; Provisional; Region: PRK05354
447217005339	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
447217005340	active site
447217005341	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217005342	catalytic residues [active]
447217005343	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
447217005344	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
447217005345	Dodecin; Region: Dodecin; cl01328
447217005346	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
447217005347	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217005348	heme-binding residues [chemical binding]; other site
447217005349	HYR domain; Region: HYR; pfam02494
447217005350	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217005351	HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244
447217005352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217005353	sequence-specific DNA binding site [nucleotide binding]; other site
447217005354	salt bridge; other site
447217005355	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217005356	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217005357	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217005358	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217005359	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217005360	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217005361	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217005362	active site
447217005363	Permease; Region: Permease; cl00510
447217005364	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217005365	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
447217005366	Walker A/P-loop; other site
447217005367	ATP binding site [chemical binding]; other site
447217005368	Q-loop/lid; other site
447217005369	ABC transporter signature motif; other site
447217005370	Walker B; other site
447217005371	D-loop; other site
447217005372	H-loop/switch region; other site
447217005373	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
447217005374	mce related protein; Region: MCE; pfam02470
447217005375	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217005376	catalytic residues [active]
447217005377	Domain of unknown function (DUF329); Region: DUF329; cl01144
447217005378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005379	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
447217005380	Beta propeller domain; Region: Beta_propel; pfam09826
447217005381	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
447217005382	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
447217005383	active site
447217005384	catalytic triad [active]
447217005385	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217005386	enoyl-CoA hydratase; Validated; Region: PRK08139
447217005387	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217005388	substrate binding site [chemical binding]; other site
447217005389	oxyanion hole (OAH) forming residues; other site
447217005390	trimer interface [polypeptide binding]; other site
447217005391	GAF domain; Region: GAF; cl15785
447217005392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217005393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005394	ATP binding site [chemical binding]; other site
447217005395	Mg2+ binding site [ion binding]; other site
447217005396	G-X-G motif; other site
447217005397	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
447217005398	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217005399	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
447217005400	DNA binding site [nucleotide binding]
447217005401	active site
447217005402	Int/Topo IB signature motif; other site
447217005403	catalytic residues [active]
447217005404	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
447217005405	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
447217005406	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
447217005407	B12 binding site [chemical binding]; other site
447217005408	cobalt ligand [ion binding]; other site
447217005409	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
447217005410	active site
447217005411	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
447217005412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217005413	FeS/SAM binding site; other site
447217005414	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
447217005415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005416	active site
447217005417	phosphorylation site [posttranslational modification]
447217005418	intermolecular recognition site; other site
447217005419	dimerization interface [polypeptide binding]; other site
447217005420	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
447217005421	Zn2+ binding site [ion binding]; other site
447217005422	Mg2+ binding site [ion binding]; other site
447217005423	lipoyl synthase; Provisional; Region: PRK05481
447217005424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217005425	FeS/SAM binding site; other site
447217005426	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
447217005427	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
447217005428	TPP-binding site [chemical binding]; other site
447217005429	tetramer interface [polypeptide binding]; other site
447217005430	heterodimer interface [polypeptide binding]; other site
447217005431	phosphorylation loop region [posttranslational modification]
447217005432	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
447217005433	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
447217005434	alpha subunit interface [polypeptide binding]; other site
447217005435	TPP binding site [chemical binding]; other site
447217005436	heterodimer interface [polypeptide binding]; other site
447217005437	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
447217005438	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
447217005439	E3 interaction surface; other site
447217005440	lipoyl attachment site [posttranslational modification]; other site
447217005441	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
447217005442	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
447217005443	active site
447217005444	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
447217005445	putative ATP binding site [chemical binding]; other site
447217005446	putative substrate interface [chemical binding]; other site
447217005447	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
447217005448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217005450	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217005451	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
447217005452	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
447217005453	nudix motif; other site
447217005454	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217005455	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217005456	active site
447217005457	ATP binding site [chemical binding]; other site
447217005458	substrate binding site [chemical binding]; other site
447217005459	activation loop (A-loop); other site
447217005460	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217005461	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217005462	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217005463	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217005464	active site
447217005465	ATP binding site [chemical binding]; other site
447217005466	substrate binding site [chemical binding]; other site
447217005467	activation loop (A-loop); other site
447217005468	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217005469	Predicted ATPase [General function prediction only]; Region: COG3899
447217005470	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217005471	phosphopeptide binding site; other site
447217005472	aspartate kinase; Validated; Region: PRK09181
447217005473	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
447217005474	nucleotide binding site [chemical binding]; other site
447217005475	substrate binding site [chemical binding]; other site
447217005476	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217005477	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217005478	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
447217005479	active sites [active]
447217005480	tetramer interface [polypeptide binding]; other site
447217005481	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
447217005482	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217005483	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
447217005484	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217005485	DXD motif; other site
447217005486	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
447217005487	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
447217005488	active site
447217005489	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
447217005490	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217005491	Family description; Region: UvrD_C_2; cl15862
447217005492	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217005493	SCP-2 sterol transfer family; Region: SCP2; cl01225
447217005494	PAS fold; Region: PAS_4; pfam08448
447217005495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217005496	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217005497	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217005498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005499	ATP binding site [chemical binding]; other site
447217005500	Mg2+ binding site [ion binding]; other site
447217005501	G-X-G motif; other site
447217005502	pyrophosphatase PpaX; Provisional; Region: PRK13288
447217005503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217005504	active site
447217005505	motif I; other site
447217005506	motif II; other site
447217005507	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217005508	prephenate dehydratase; Provisional; Region: PRK11898
447217005509	Prephenate dehydratase; Region: PDT; pfam00800
447217005510	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
447217005511	putative L-Phe binding site [chemical binding]; other site
447217005512	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
447217005513	active site
447217005514	nucleophile elbow; other site
447217005515	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
447217005516	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217005517	Beta-Casp domain; Region: Beta-Casp; cl12567
447217005518	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
447217005519	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
447217005520	active site
447217005521	8-oxo-dGMP binding site [chemical binding]; other site
447217005522	nudix motif; other site
447217005523	metal binding site [ion binding]; metal-binding site
447217005524	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217005525	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217005526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005527	Walker A motif; other site
447217005528	ATP binding site [chemical binding]; other site
447217005529	Walker B motif; other site
447217005530	arginine finger; other site
447217005531	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217005532	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
447217005533	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
447217005534	dimer interface [polypeptide binding]; other site
447217005535	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
447217005536	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217005537	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217005538	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217005539	protein binding site [polypeptide binding]; other site
447217005540	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
447217005541	protein binding site [polypeptide binding]; other site
447217005542	PilZ domain; Region: PilZ; cl01260
447217005543	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
447217005544	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217005545	Walker A/P-loop; other site
447217005546	ATP binding site [chemical binding]; other site
447217005547	Q-loop/lid; other site
447217005548	ABC transporter signature motif; other site
447217005549	Walker B; other site
447217005550	D-loop; other site
447217005551	H-loop/switch region; other site
447217005552	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
447217005553	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
447217005554	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
447217005555	NAD(P) binding site [chemical binding]; other site
447217005556	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
447217005557	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217005558	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
447217005559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217005560	Histidine kinase; Region: HisKA_3; pfam07730
447217005561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217005562	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217005563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005564	active site
447217005565	phosphorylation site [posttranslational modification]
447217005566	intermolecular recognition site; other site
447217005567	dimerization interface [polypeptide binding]; other site
447217005568	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217005569	DNA binding residues [nucleotide binding]
447217005570	dimerization interface [polypeptide binding]; other site
447217005571	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
447217005572	gating phenylalanine in ion channel; other site
447217005573	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
447217005574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
447217005575	substrate binding pocket [chemical binding]; other site
447217005576	membrane-bound complex binding site; other site
447217005577	hinge residues; other site
447217005578	sensory histidine kinase AtoS; Provisional; Region: PRK11360
447217005579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005580	ATP binding site [chemical binding]; other site
447217005581	Mg2+ binding site [ion binding]; other site
447217005582	G-X-G motif; other site
447217005583	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217005584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217005585	active site
447217005586	phosphorylation site [posttranslational modification]
447217005587	intermolecular recognition site; other site
447217005588	dimerization interface [polypeptide binding]; other site
447217005589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005590	Walker A motif; other site
447217005591	ATP binding site [chemical binding]; other site
447217005592	Walker B motif; other site
447217005593	arginine finger; other site
447217005594	Helix-turn-helix domains; Region: HTH; cl00088
447217005595	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
447217005596	Aspartase; Region: Aspartase; cd01357
447217005597	active sites [active]
447217005598	tetramer interface [polypeptide binding]; other site
447217005599	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
447217005600	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
447217005601	trimer interface [polypeptide binding]; other site
447217005602	eyelet of channel; other site
447217005603	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
447217005604	heme-binding site [chemical binding]; other site
447217005605	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217005606	Coenzyme A binding pocket [chemical binding]; other site
447217005607	RES domain; Region: RES; cl02411
447217005608	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
447217005609	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
447217005610	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217005611	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
447217005612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005613	Walker A motif; other site
447217005614	ATP binding site [chemical binding]; other site
447217005615	Walker B motif; other site
447217005616	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
447217005617	active site
447217005618	catalytic triad [active]
447217005619	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217005620	active site
447217005621	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217005622	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217005623	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217005624	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217005625	Surface antigen; Region: Bac_surface_Ag; cl03097
447217005626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217005627	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217005628	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217005629	Cation efflux family; Region: Cation_efflux; cl00316
447217005630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217005631	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217005632	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
447217005633	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
447217005634	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217005635	Walker A/P-loop; other site
447217005636	ATP binding site [chemical binding]; other site
447217005637	Q-loop/lid; other site
447217005638	ABC transporter signature motif; other site
447217005639	Walker B; other site
447217005640	D-loop; other site
447217005641	H-loop/switch region; other site
447217005642	TOBE-like domain; Region: TOBE_3; pfam12857
447217005643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217005644	dimer interface [polypeptide binding]; other site
447217005645	conserved gate region; other site
447217005646	putative PBP binding loops; other site
447217005647	ABC-ATPase subunit interface; other site
447217005648	sulfate transport protein; Provisional; Region: cysT; CHL00187
447217005649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217005650	dimer interface [polypeptide binding]; other site
447217005651	conserved gate region; other site
447217005652	putative PBP binding loops; other site
447217005653	ABC-ATPase subunit interface; other site
447217005654	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
447217005655	Active Sites [active]
447217005656	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
447217005657	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
447217005658	CysD dimerization site [polypeptide binding]; other site
447217005659	G1 box; other site
447217005660	putative GEF interaction site [polypeptide binding]; other site
447217005661	GTP/Mg2+ binding site [chemical binding]; other site
447217005662	Switch I region; other site
447217005663	G2 box; other site
447217005664	G3 box; other site
447217005665	Switch II region; other site
447217005666	G4 box; other site
447217005667	G5 box; other site
447217005668	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
447217005669	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
447217005670	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
447217005671	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
447217005672	Active Sites [active]
447217005673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217005674	S-adenosylmethionine binding site [chemical binding]; other site
447217005675	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
447217005676	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
447217005677	active site
447217005678	(T/H)XGH motif; other site
447217005679	aspartate aminotransferase; Provisional; Region: PRK05764
447217005680	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217005681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005682	homodimer interface [polypeptide binding]; other site
447217005683	catalytic residue [active]
447217005684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217005685	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
447217005686	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217005687	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217005688	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
447217005689	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217005690	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217005691	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
447217005692	IMP binding site; other site
447217005693	dimer interface [polypeptide binding]; other site
447217005694	interdomain contacts; other site
447217005695	partial ornithine binding site; other site
447217005696	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
447217005697	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
447217005698	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217005699	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
447217005700	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
447217005701	generic binding surface II; other site
447217005702	ssDNA binding site; other site
447217005703	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217005704	ATP binding site [chemical binding]; other site
447217005705	putative Mg++ binding site [ion binding]; other site
447217005706	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217005707	nucleotide binding region [chemical binding]; other site
447217005708	ATP-binding site [chemical binding]; other site
447217005709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005710	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
447217005711	aminotransferase; Validated; Region: PRK08175
447217005712	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217005713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005714	homodimer interface [polypeptide binding]; other site
447217005715	catalytic residue [active]
447217005716	threonine synthase; Region: PLN02569
447217005717	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
447217005718	homodimer interface [polypeptide binding]; other site
447217005719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217005720	catalytic residue [active]
447217005721	thymidylate kinase; Region: DTMP_kinase; TIGR00041
447217005722	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
447217005723	TMP-binding site; other site
447217005724	ATP-binding site [chemical binding]; other site
447217005725	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
447217005726	putative MPT binding site; other site
447217005727	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217005728	Cytochrome c; Region: Cytochrom_C; cl11414
447217005729	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
447217005730	Di-iron ligands [ion binding]; other site
447217005731	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217005732	putative acyl-acceptor binding pocket; other site
447217005733	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
447217005734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217005735	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
447217005736	ATP binding site [chemical binding]; other site
447217005737	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
447217005738	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
447217005739	phosphopeptide binding site; other site
447217005740	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
447217005741	GAF domain; Region: GAF; cl15785
447217005742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005743	Walker A motif; other site
447217005744	ATP binding site [chemical binding]; other site
447217005745	Walker B motif; other site
447217005746	arginine finger; other site
447217005747	Helix-turn-helix domains; Region: HTH; cl00088
447217005748	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217005749	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217005750	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217005751	active site
447217005752	ATP binding site [chemical binding]; other site
447217005753	substrate binding site [chemical binding]; other site
447217005754	activation loop (A-loop); other site
447217005755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005756	active site
447217005757	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217005758	ATP-dependent protease La; Region: lon; TIGR00763
447217005759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217005760	Walker A motif; other site
447217005761	ATP binding site [chemical binding]; other site
447217005762	Walker B motif; other site
447217005763	arginine finger; other site
447217005764	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
447217005765	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
447217005766	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217005767	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
447217005768	Helix-turn-helix domains; Region: HTH; cl00088
447217005769	LexA repressor; Validated; Region: PRK00215
447217005770	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
447217005771	Catalytic site [active]
447217005772	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
447217005773	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217005774	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
447217005775	active site
447217005776	ATP binding site [chemical binding]; other site
447217005777	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
447217005778	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217005779	active site
447217005780	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
447217005781	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
447217005782	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
447217005783	NodB motif; other site
447217005784	putative active site [active]
447217005785	putative catalytic site [active]
447217005786	putative Zn binding site [ion binding]; other site
447217005787	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
447217005788	MutS domain I; Region: MutS_I; pfam01624
447217005789	MutS family domain IV; Region: MutS_IV; pfam05190
447217005790	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
447217005791	Walker A/P-loop; other site
447217005792	ATP binding site [chemical binding]; other site
447217005793	Q-loop/lid; other site
447217005794	ABC transporter signature motif; other site
447217005795	Walker B; other site
447217005796	D-loop; other site
447217005797	H-loop/switch region; other site
447217005798	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217005799	heme-binding residues [chemical binding]; other site
447217005800	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
447217005801	heme-binding residues [chemical binding]; other site
447217005802	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
447217005803	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
447217005804	conserved cys residue [active]
447217005805	AMIN domain; Region: AMIN; pfam11741
447217005806	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
447217005807	active site
447217005808	metal binding site [ion binding]; metal-binding site
447217005809	Transposase domain (DUF772); Region: DUF772; cl15789
447217005810	Transposase domain (DUF772); Region: DUF772; cl15789
447217005811	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
447217005812	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217005813	PII uridylyl-transferase; Provisional; Region: PRK05092
447217005814	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217005815	metal binding triad; other site
447217005816	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
447217005817	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217005818	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217005819	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
447217005820	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
447217005821	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217005822	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
447217005823	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
447217005824	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
447217005825	Int/Topo IB signature motif; other site
447217005826	active site
447217005827	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
447217005828	active site
447217005829	putative substrate binding region [chemical binding]; other site
447217005830	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
447217005831	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
447217005832	active site
447217005833	HIGH motif; other site
447217005834	dimer interface [polypeptide binding]; other site
447217005835	KMSKS motif; other site
447217005836	ScpA/B protein; Region: ScpA_ScpB; cl00598
447217005837	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
447217005838	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
447217005839	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
447217005840	RNA binding surface [nucleotide binding]; other site
447217005841	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
447217005842	active site
447217005843	Secretin and TonB N terminus short domain; Region: STN; cl06624
447217005844	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
447217005845	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
447217005846	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217005847	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217005848	DNA binding residues [nucleotide binding]
447217005849	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217005850	transmembrane helices; other site
447217005851	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
447217005852	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288
447217005853	putative active site [active]
447217005854	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
447217005855	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
447217005856	Domain of unknown function DUF59; Region: DUF59; cl00941
447217005857	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
447217005858	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
447217005859	Walker A motif; other site
447217005860	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
447217005861	active site
447217005862	catalytic residues [active]
447217005863	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217005864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217005865	PAS domain; Region: PAS_9; pfam13426
447217005866	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217005867	dimer interface [polypeptide binding]; other site
447217005868	phosphorylation site [posttranslational modification]
447217005869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217005870	ATP binding site [chemical binding]; other site
447217005871	Mg2+ binding site [ion binding]; other site
447217005872	G-X-G motif; other site
447217005873	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
447217005874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005875	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
447217005876	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
447217005877	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217005878	substrate binding site [chemical binding]; other site
447217005879	oxyanion hole (OAH) forming residues; other site
447217005880	trimer interface [polypeptide binding]; other site
447217005881	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
447217005882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217005883	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
447217005884	FAD binding site [chemical binding]; other site
447217005885	homotetramer interface [polypeptide binding]; other site
447217005886	substrate binding pocket [chemical binding]; other site
447217005887	catalytic base [active]
447217005888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217005889	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217005890	active site
447217005891	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
447217005892	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217005893	dimerization interface [polypeptide binding]; other site
447217005894	active site
447217005895	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
447217005896	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
447217005897	DNA binding residues [nucleotide binding]
447217005898	dimer interface [polypeptide binding]; other site
447217005899	Transposase domain (DUF772); Region: DUF772; cl15789
447217005900	Transposase domain (DUF772); Region: DUF772; cl15789
447217005901	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217005902	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
447217005903	active site
447217005904	8-oxo-dGMP binding site [chemical binding]; other site
447217005905	nudix motif; other site
447217005906	metal binding site [ion binding]; metal-binding site
447217005907	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
447217005908	PQQ-like domain; Region: PQQ_2; pfam13360
447217005909	Trp docking motif [polypeptide binding]; other site
447217005910	active site
447217005911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
447217005912	GTP-binding protein Der; Reviewed; Region: PRK00093
447217005913	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
447217005914	G1 box; other site
447217005915	GTP/Mg2+ binding site [chemical binding]; other site
447217005916	Switch I region; other site
447217005917	G2 box; other site
447217005918	Switch II region; other site
447217005919	G3 box; other site
447217005920	G4 box; other site
447217005921	G5 box; other site
447217005922	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
447217005923	G1 box; other site
447217005924	GTP/Mg2+ binding site [chemical binding]; other site
447217005925	Switch I region; other site
447217005926	G2 box; other site
447217005927	G3 box; other site
447217005928	Switch II region; other site
447217005929	G4 box; other site
447217005930	G5 box; other site
447217005931	GTPase Era; Reviewed; Region: era; PRK00089
447217005932	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
447217005933	G1 box; other site
447217005934	GTP/Mg2+ binding site [chemical binding]; other site
447217005935	Switch I region; other site
447217005936	G2 box; other site
447217005937	Switch II region; other site
447217005938	G3 box; other site
447217005939	G4 box; other site
447217005940	G5 box; other site
447217005941	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
447217005942	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
447217005943	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217005944	active site
447217005945	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217005946	active site
447217005947	ribonuclease III; Reviewed; Region: rnc; PRK00102
447217005948	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
447217005949	dimerization interface [polypeptide binding]; other site
447217005950	active site
447217005951	metal binding site [ion binding]; metal-binding site
447217005952	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
447217005953	dsRNA binding site [nucleotide binding]; other site
447217005954	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
447217005955	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
447217005956	Walker A; other site
447217005957	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
447217005958	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217005959	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217005960	active site
447217005961	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217005962	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217005963	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217005964	enoyl-CoA hydratase; Provisional; Region: PRK06688
447217005965	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217005966	substrate binding site [chemical binding]; other site
447217005967	oxyanion hole (OAH) forming residues; other site
447217005968	trimer interface [polypeptide binding]; other site
447217005969	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
447217005970	active site
447217005971	catalytic residues [active]
447217005972	metal binding site [ion binding]; metal-binding site
447217005973	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217005974	active site residue [active]
447217005975	ThiC family; Region: ThiC; cl08031
447217005976	enolase; Provisional; Region: eno; PRK00077
447217005977	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
447217005978	dimer interface [polypeptide binding]; other site
447217005979	metal binding site [ion binding]; metal-binding site
447217005980	substrate binding pocket [chemical binding]; other site
447217005981	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
447217005982	hydrophobic ligand binding site; other site
447217005983	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
447217005984	putative active site [active]
447217005985	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217005986	active site
447217005987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217005988	homoserine dehydrogenase; Provisional; Region: PRK06349
447217005989	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217005990	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
447217005991	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
447217005992	HEAT repeats; Region: HEAT_2; pfam13646
447217005993	Restriction endonuclease; Region: Mrr_cat; cl00516
447217005994	PQQ-like domain; Region: PQQ_2; pfam13360
447217005995	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217005996	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217005997	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217005998	substrate binding site [chemical binding]; other site
447217005999	ATP binding site [chemical binding]; other site
447217006000	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
447217006001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217006002	FeS/SAM binding site; other site
447217006003	Domain of unknown function DUF21; Region: DUF21; pfam01595
447217006004	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
447217006005	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217006006	Transporter associated domain; Region: CorC_HlyC; cl08393
447217006007	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
447217006008	active site
447217006009	multimer interface [polypeptide binding]; other site
447217006010	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
447217006011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006012	CoA-ligase; Region: Ligase_CoA; cl02894
447217006013	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
447217006014	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217006015	CoA-ligase; Region: Ligase_CoA; cl02894
447217006016	malate dehydrogenase; Reviewed; Region: PRK06223
447217006017	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
447217006018	NAD(P) binding site [chemical binding]; other site
447217006019	dimer interface [polypeptide binding]; other site
447217006020	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217006021	substrate binding site [chemical binding]; other site
447217006022	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
447217006023	isocitrate dehydrogenase; Validated; Region: PRK07362
447217006024	YdjC-like protein; Region: YdjC; cl01344
447217006025	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217006026	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006027	putative active site [active]
447217006028	heme pocket [chemical binding]; other site
447217006029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217006030	phosphorylation site [posttranslational modification]
447217006031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006032	ATP binding site [chemical binding]; other site
447217006033	Mg2+ binding site [ion binding]; other site
447217006034	G-X-G motif; other site
447217006035	Bifunctional nuclease; Region: DNase-RNase; cl00553
447217006036	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
447217006037	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
447217006038	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
447217006039	catalytic site [active]
447217006040	subunit interface [polypeptide binding]; other site
447217006041	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217006042	dihydroorotase; Validated; Region: pyrC; PRK09357
447217006043	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
447217006044	active site
447217006045	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
447217006046	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
447217006047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217006049	active site
447217006050	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
447217006051	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217006052	Catalytic site [active]
447217006053	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217006054	GTP-binding protein LepA; Provisional; Region: PRK05433
447217006055	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
447217006056	G1 box; other site
447217006057	putative GEF interaction site [polypeptide binding]; other site
447217006058	GTP/Mg2+ binding site [chemical binding]; other site
447217006059	Switch I region; other site
447217006060	G2 box; other site
447217006061	G3 box; other site
447217006062	Switch II region; other site
447217006063	G4 box; other site
447217006064	G5 box; other site
447217006065	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
447217006066	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
447217006067	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
447217006068	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
447217006069	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
447217006070	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
447217006071	active site
447217006072	dimer interface [polypeptide binding]; other site
447217006073	effector binding site; other site
447217006074	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
447217006075	TSCPD domain; Region: TSCPD; cl14834
447217006076	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
447217006077	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
447217006078	DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135
447217006079	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
447217006080	generic binding surface I; other site
447217006081	generic binding surface II; other site
447217006082	Y-family of DNA polymerases; Region: PolY; cl12025
447217006083	active site
447217006084	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006085	Walker A motif; other site
447217006086	ATP binding site [chemical binding]; other site
447217006087	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217006088	catalytic residues [active]
447217006089	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
447217006090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006091	active site
447217006092	phosphorylation site [posttranslational modification]
447217006093	intermolecular recognition site; other site
447217006094	dimerization interface [polypeptide binding]; other site
447217006095	Helix-turn-helix domains; Region: HTH; cl00088
447217006096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006098	ATP binding site [chemical binding]; other site
447217006099	Mg2+ binding site [ion binding]; other site
447217006100	G-X-G motif; other site
447217006101	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
447217006102	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
447217006103	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217006104	catalytic residue [active]
447217006105	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
447217006106	putative active site [active]
447217006107	catalytic site [active]
447217006108	putative substrate binding site [chemical binding]; other site
447217006109	HRDC domain; Region: HRDC; cl02578
447217006110	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
447217006111	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217006112	putative acyl-acceptor binding pocket; other site
447217006113	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006115	active site
447217006116	phosphorylation site [posttranslational modification]
447217006117	intermolecular recognition site; other site
447217006118	dimerization interface [polypeptide binding]; other site
447217006119	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
447217006120	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
447217006121	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006122	Walker A motif; other site
447217006123	ATP binding site [chemical binding]; other site
447217006124	Walker B motif; other site
447217006125	flagellar assembly protein H; Validated; Region: fliH; PRK06669
447217006126	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
447217006127	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217006128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217006129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217006130	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
447217006131	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
447217006132	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
447217006133	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
447217006134	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
447217006135	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
447217006136	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
447217006137	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
447217006138	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
447217006139	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
447217006140	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
447217006141	DNA binding site [nucleotide binding]
447217006142	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
447217006143	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
447217006144	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
447217006145	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
447217006146	RPB11 interaction site [polypeptide binding]; other site
447217006147	RPB12 interaction site [polypeptide binding]; other site
447217006148	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
447217006149	RPB3 interaction site [polypeptide binding]; other site
447217006150	RPB1 interaction site [polypeptide binding]; other site
447217006151	RPB11 interaction site [polypeptide binding]; other site
447217006152	RPB10 interaction site [polypeptide binding]; other site
447217006153	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
447217006154	core dimer interface [polypeptide binding]; other site
447217006155	peripheral dimer interface [polypeptide binding]; other site
447217006156	L10 interface [polypeptide binding]; other site
447217006157	L11 interface [polypeptide binding]; other site
447217006158	putative EF-Tu interaction site [polypeptide binding]; other site
447217006159	putative EF-G interaction site [polypeptide binding]; other site
447217006160	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
447217006161	23S rRNA interface [nucleotide binding]; other site
447217006162	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
447217006163	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
447217006164	mRNA/rRNA interface [nucleotide binding]; other site
447217006165	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
447217006166	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
447217006167	23S rRNA interface [nucleotide binding]; other site
447217006168	L7/L12 interface [polypeptide binding]; other site
447217006169	putative thiostrepton binding site; other site
447217006170	L25 interface [polypeptide binding]; other site
447217006171	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
447217006172	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
447217006173	putative homodimer interface [polypeptide binding]; other site
447217006174	KOW motif; Region: KOW; cl00354
447217006175	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
447217006176	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
447217006177	elongation factor Tu; Reviewed; Region: PRK00049
447217006178	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
447217006179	G1 box; other site
447217006180	GEF interaction site [polypeptide binding]; other site
447217006181	GTP/Mg2+ binding site [chemical binding]; other site
447217006182	Switch I region; other site
447217006183	G2 box; other site
447217006184	G3 box; other site
447217006185	Switch II region; other site
447217006186	G4 box; other site
447217006187	G5 box; other site
447217006188	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
447217006189	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
447217006190	Antibiotic Binding Site [chemical binding]; other site
447217006191	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
447217006192	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
447217006193	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
447217006194	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
447217006195	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217006196	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217006197	Protein of unknown function (DUF493); Region: DUF493; cl01102
447217006198	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
447217006199	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
447217006200	putative active site [active]
447217006201	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006202	GAF domain; Region: GAF; cl15785
447217006203	GAF domain; Region: GAF_2; pfam13185
447217006204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217006205	metal binding site [ion binding]; metal-binding site
447217006206	active site
447217006207	I-site; other site
447217006208	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
447217006209	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217006210	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
447217006211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217006212	putative substrate translocation pore; other site
447217006213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217006214	Helix-turn-helix domains; Region: HTH; cl00088
447217006215	ApbE family; Region: ApbE; cl00643
447217006216	FMN-binding domain; Region: FMN_bind; cl01081
447217006217	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
447217006218	FeoA domain; Region: FeoA; cl00838
447217006219	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
447217006220	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
447217006221	G1 box; other site
447217006222	GTP/Mg2+ binding site [chemical binding]; other site
447217006223	Switch I region; other site
447217006224	G2 box; other site
447217006225	G3 box; other site
447217006226	Switch II region; other site
447217006227	G4 box; other site
447217006228	G5 box; other site
447217006229	Nucleoside recognition; Region: Gate; cl00486
447217006230	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
447217006231	Nucleoside recognition; Region: Gate; cl00486
447217006232	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
447217006233	metal binding site 2 [ion binding]; metal-binding site
447217006234	putative DNA binding helix; other site
447217006235	metal binding site 1 [ion binding]; metal-binding site
447217006236	dimer interface [polypeptide binding]; other site
447217006237	structural Zn2+ binding site [ion binding]; other site
447217006238	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
447217006239	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
447217006240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006242	ATP binding site [chemical binding]; other site
447217006243	Mg2+ binding site [ion binding]; other site
447217006244	G-X-G motif; other site
447217006245	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
447217006246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217006247	binding surface
447217006248	TPR motif; other site
447217006249	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217006250	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006252	active site
447217006253	phosphorylation site [posttranslational modification]
447217006254	intermolecular recognition site; other site
447217006255	dimerization interface [polypeptide binding]; other site
447217006256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217006257	metal binding site [ion binding]; metal-binding site
447217006258	active site
447217006259	I-site; other site
447217006260	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217006261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006262	active site
447217006263	phosphorylation site [posttranslational modification]
447217006264	intermolecular recognition site; other site
447217006265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006266	Walker A motif; other site
447217006267	ATP binding site [chemical binding]; other site
447217006268	Walker B motif; other site
447217006269	arginine finger; other site
447217006270	Helix-turn-helix domains; Region: HTH; cl00088
447217006271	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
447217006272	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
447217006273	putative active site [active]
447217006274	putative metal binding site [ion binding]; other site
447217006275	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
447217006276	catalytic motif [active]
447217006277	Zn binding site [ion binding]; other site
447217006278	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217006279	PrkA AAA domain; Region: AAA_PrkA; smart00763
447217006280	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
447217006281	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217006282	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217006283	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
447217006284	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006286	Walker A motif; other site
447217006287	ATP binding site [chemical binding]; other site
447217006288	Walker B motif; other site
447217006289	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217006290	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
447217006291	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
447217006292	active site
447217006293	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
447217006294	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
447217006295	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
447217006296	Ligand Binding Site [chemical binding]; other site
447217006297	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
447217006298	ligand-binding site [chemical binding]; other site
447217006299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006300	ATP binding site [chemical binding]; other site
447217006301	substrate interface [chemical binding]; other site
447217006302	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217006303	CPxP  motif; other site
447217006304	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
447217006305	ATP binding site [chemical binding]; other site
447217006306	substrate interface [chemical binding]; other site
447217006307	PilZ domain; Region: PilZ; cl01260
447217006308	Hsp70 protein; Region: HSP70; pfam00012
447217006309	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
447217006310	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
447217006311	Ferredoxin [Energy production and conversion]; Region: COG1146
447217006312	4Fe-4S binding domain; Region: Fer4; cl02805
447217006313	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
447217006314	Preprotein translocase SecG subunit; Region: SecG; cl09123
447217006315	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
447217006316	substrate binding site [chemical binding]; other site
447217006317	dimer interface [polypeptide binding]; other site
447217006318	catalytic triad [active]
447217006319	Phosphoglycerate kinase; Region: PGK; pfam00162
447217006320	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
447217006321	substrate binding site [chemical binding]; other site
447217006322	hinge regions; other site
447217006323	ADP binding site [chemical binding]; other site
447217006324	catalytic site [active]
447217006325	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
447217006326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006327	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
447217006328	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
447217006329	Cupin domain; Region: Cupin_2; cl09118
447217006330	Sporulation related domain; Region: SPOR; cl10051
447217006331	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
447217006332	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
447217006333	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
447217006334	active site
447217006335	HIGH motif; other site
447217006336	KMSK motif region; other site
447217006337	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
447217006338	tRNA binding surface [nucleotide binding]; other site
447217006339	anticodon binding site; other site
447217006340	tetratricopeptide repeat protein; Provisional; Region: PRK11788
447217006341	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
447217006342	nucleotide binding site/active site [active]
447217006343	HIT family signature motif; other site
447217006344	catalytic residue [active]
447217006345	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
447217006346	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
447217006347	tandem repeat interface [polypeptide binding]; other site
447217006348	oligomer interface [polypeptide binding]; other site
447217006349	active site residues [active]
447217006350	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
447217006351	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
447217006352	RNA binding site [nucleotide binding]; other site
447217006353	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
447217006354	RNA binding site [nucleotide binding]; other site
447217006355	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
447217006356	RNA binding site [nucleotide binding]; other site
447217006357	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217006358	RNA binding site [nucleotide binding]; other site
447217006359	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
447217006360	RNA binding site [nucleotide binding]; other site
447217006361	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217006362	RNA binding site [nucleotide binding]; other site
447217006363	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
447217006364	LytB protein; Region: LYTB; cl00507
447217006365	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217006366	cytidylate kinase; Provisional; Region: cmk; PRK00023
447217006367	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006368	active site
447217006369	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
447217006370	CMP-binding site; other site
447217006371	The sites determining sugar specificity; other site
447217006372	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
447217006373	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217006374	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
447217006375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006376	histidyl-tRNA synthetase; Region: hisS; TIGR00442
447217006377	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
447217006378	dimer interface [polypeptide binding]; other site
447217006379	motif 1; other site
447217006380	active site
447217006381	motif 2; other site
447217006382	motif 3; other site
447217006383	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
447217006384	anticodon binding site; other site
447217006385	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
447217006386	urocanate hydratase; Provisional; Region: PRK05414
447217006387	imidazolonepropionase; Validated; Region: PRK09356
447217006388	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
447217006389	active site
447217006390	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
447217006391	active site
447217006392	metal binding site [ion binding]; metal-binding site
447217006393	homotetramer interface [polypeptide binding]; other site
447217006394	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
447217006395	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
447217006396	putative active site [active]
447217006397	putative dimer interface [polypeptide binding]; other site
447217006398	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
447217006399	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
447217006400	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
447217006401	putative substrate binding site [chemical binding]; other site
447217006402	putative ATP binding site [chemical binding]; other site
447217006403	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
447217006404	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
447217006405	active site
447217006406	hydrophilic channel; other site
447217006407	dimerization interface [polypeptide binding]; other site
447217006408	catalytic residues [active]
447217006409	active site lid [active]
447217006410	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
447217006411	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
447217006412	active site
447217006413	substrate binding site [chemical binding]; other site
447217006414	metal binding site [ion binding]; metal-binding site
447217006415	Uncharacterized conserved protein [Function unknown]; Region: COG1624
447217006416	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
447217006417	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
447217006418	dihydropteroate synthase; Region: DHPS; TIGR01496
447217006419	substrate binding pocket [chemical binding]; other site
447217006420	dimer interface [polypeptide binding]; other site
447217006421	inhibitor binding site; inhibition site
447217006422	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217006423	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217006424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006425	Walker A motif; other site
447217006426	ATP binding site [chemical binding]; other site
447217006427	Walker B motif; other site
447217006428	arginine finger; other site
447217006429	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217006430	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
447217006431	B3/4 domain; Region: B3_4; cl11458
447217006432	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
447217006433	PilZ domain; Region: PilZ; cl01260
447217006434	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217006435	IHF dimer interface [polypeptide binding]; other site
447217006436	IHF - DNA interface [nucleotide binding]; other site
447217006437	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
447217006438	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217006439	active site 2 [active]
447217006440	active site 1 [active]
447217006441	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217006442	B12 binding site [chemical binding]; other site
447217006443	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
447217006444	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
447217006445	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
447217006446	Ligand Binding Site [chemical binding]; other site
447217006447	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
447217006448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006449	active site
447217006450	phosphorylation site [posttranslational modification]
447217006451	intermolecular recognition site; other site
447217006452	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006453	dimer interface [polypeptide binding]; other site
447217006454	phosphorylation site [posttranslational modification]
447217006455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006456	ATP binding site [chemical binding]; other site
447217006457	Mg2+ binding site [ion binding]; other site
447217006458	G-X-G motif; other site
447217006459	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
447217006460	active site
447217006461	NTP binding site [chemical binding]; other site
447217006462	metal binding triad [ion binding]; metal-binding site
447217006463	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
447217006464	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
447217006465	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217006466	Phage Tail Collar Domain; Region: Collar; pfam07484
447217006467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006468	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217006469	Walker A motif; other site
447217006470	ATP binding site [chemical binding]; other site
447217006471	Walker B motif; other site
447217006472	arginine finger; other site
447217006473	Helix-turn-helix domains; Region: HTH; cl00088
447217006474	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217006475	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217006476	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217006477	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217006478	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217006479	Helix-turn-helix domains; Region: HTH; cl00088
447217006480	PAS fold; Region: PAS_4; pfam08448
447217006481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006482	putative active site [active]
447217006483	heme pocket [chemical binding]; other site
447217006484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006486	ATP binding site [chemical binding]; other site
447217006487	Mg2+ binding site [ion binding]; other site
447217006488	G-X-G motif; other site
447217006489	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217006490	hypothetical protein; Provisional; Region: PRK13560
447217006491	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217006492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217006493	putative active site [active]
447217006494	heme pocket [chemical binding]; other site
447217006495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006496	dimer interface [polypeptide binding]; other site
447217006497	phosphorylation site [posttranslational modification]
447217006498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006499	ATP binding site [chemical binding]; other site
447217006500	Mg2+ binding site [ion binding]; other site
447217006501	G-X-G motif; other site
447217006502	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006504	active site
447217006505	phosphorylation site [posttranslational modification]
447217006506	intermolecular recognition site; other site
447217006507	dimerization interface [polypeptide binding]; other site
447217006508	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217006509	active site
447217006510	Helix-turn-helix domains; Region: HTH; cl00088
447217006511	YCII-related domain; Region: YCII; cl00999
447217006512	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217006513	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
447217006514	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217006515	dimerization interface [polypeptide binding]; other site
447217006516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217006517	S-adenosylmethionine binding site [chemical binding]; other site
447217006518	Cupin domain; Region: Cupin_2; cl09118
447217006519	Cupin domain; Region: Cupin_2; cl09118
447217006520	Adenosine specific kinase; Region: Adenosine_kin; cl00796
447217006521	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
447217006522	30S subunit binding site; other site
447217006523	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217006524	DNA-binding site [nucleotide binding]; DNA binding site
447217006525	RNA-binding motif; other site
447217006526	YceI-like domain; Region: YceI; cl01001
447217006527	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217006528	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
447217006529	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217006530	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217006531	active site
447217006532	metal binding site [ion binding]; metal-binding site
447217006533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
447217006534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006535	dimer interface [polypeptide binding]; other site
447217006536	phosphorylation site [posttranslational modification]
447217006537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006538	ATP binding site [chemical binding]; other site
447217006539	G-X-G motif; other site
447217006540	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217006541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006542	active site
447217006543	phosphorylation site [posttranslational modification]
447217006544	intermolecular recognition site; other site
447217006545	dimerization interface [polypeptide binding]; other site
447217006546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006547	Walker A motif; other site
447217006548	ATP binding site [chemical binding]; other site
447217006549	Walker B motif; other site
447217006550	arginine finger; other site
447217006551	Helix-turn-helix domains; Region: HTH; cl00088
447217006552	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006553	Ligand Binding Site [chemical binding]; other site
447217006554	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
447217006555	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006556	Ligand Binding Site [chemical binding]; other site
447217006557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217006558	DNA binding residues [nucleotide binding]
447217006559	dimerization interface [polypeptide binding]; other site
447217006560	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
447217006561	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
447217006562	Cl- selectivity filter; other site
447217006563	Cl- binding residues [ion binding]; other site
447217006564	pore gating glutamate residue; other site
447217006565	dimer interface [polypeptide binding]; other site
447217006566	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217006567	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
447217006568	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217006569	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
447217006570	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
447217006571	active site
447217006572	homotetramer interface [polypeptide binding]; other site
447217006573	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
447217006574	putative active site [active]
447217006575	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
447217006576	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
447217006577	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
447217006578	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
447217006579	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006580	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
447217006581	AMP-binding enzyme; Region: AMP-binding; cl15778
447217006582	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
447217006583	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
447217006584	active site
447217006585	catalytic residues [active]
447217006586	metal binding site [ion binding]; metal-binding site
447217006587	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217006588	EamA-like transporter family; Region: EamA; cl01037
447217006589	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217006590	active site
447217006591	nucleophile elbow; other site
447217006592	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
447217006593	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217006594	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
447217006595	D-cysteine desulfhydrase; Validated; Region: PRK03910
447217006596	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
447217006597	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217006598	catalytic residue [active]
447217006599	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217006600	DTW domain; Region: DTW; cl01221
447217006601	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
447217006602	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
447217006603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217006604	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
447217006605	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
447217006606	Cytochrome c; Region: Cytochrom_C; cl11414
447217006607	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217006608	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
447217006609	4Fe-4S binding domain; Region: Fer4; cl02805
447217006610	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
447217006611	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
447217006612	Cl- selectivity filter; other site
447217006613	Cl- binding residues [ion binding]; other site
447217006614	pore gating glutamate residue; other site
447217006615	dimer interface [polypeptide binding]; other site
447217006616	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
447217006617	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217006618	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
447217006619	Zn binding site [ion binding]; other site
447217006620	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
447217006621	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217006622	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
447217006623	putative NAD(P) binding site [chemical binding]; other site
447217006624	putative substrate binding site [chemical binding]; other site
447217006625	catalytic Zn binding site [ion binding]; other site
447217006626	structural Zn binding site [ion binding]; other site
447217006627	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217006628	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217006629	active site
447217006630	oxidoreductase; Provisional; Region: PRK06196
447217006631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006632	NAD(P) binding site [chemical binding]; other site
447217006633	active site
447217006634	oxidoreductase; Provisional; Region: PRK06196
447217006635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006636	NAD(P) binding site [chemical binding]; other site
447217006637	active site
447217006638	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217006639	Helix-turn-helix domains; Region: HTH; cl00088
447217006640	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217006641	active site
447217006642	probable methyltransferase; Region: TIGR03438
447217006643	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
447217006644	TIGR03440 family protein; Region: unchr_TIGR03440
447217006645	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
447217006646	MutS domain III; Region: MutS_III; pfam05192
447217006647	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006648	Walker A/P-loop; other site
447217006649	ATP binding site [chemical binding]; other site
447217006650	Q-loop/lid; other site
447217006651	ABC transporter signature motif; other site
447217006652	Walker B; other site
447217006653	D-loop; other site
447217006654	H-loop/switch region; other site
447217006655	methionine aminopeptidase; Provisional; Region: PRK12318
447217006656	SEC-C motif; Region: SEC-C; pfam02810
447217006657	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
447217006658	active site
447217006659	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217006660	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217006661	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217006662	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217006663	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
447217006664	GAF domain; Region: GAF; cl15785
447217006665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006666	Walker A motif; other site
447217006667	ATP binding site [chemical binding]; other site
447217006668	Walker B motif; other site
447217006669	arginine finger; other site
447217006670	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
447217006671	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217006672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006673	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217006674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006675	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217006676	Walker A motif; other site
447217006677	ATP binding site [chemical binding]; other site
447217006678	Walker B motif; other site
447217006679	arginine finger; other site
447217006680	Helix-turn-helix domains; Region: HTH; cl00088
447217006681	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
447217006682	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
447217006683	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
447217006684	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217006685	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
447217006686	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
447217006687	FliG C-terminal domain; Region: FliG_C; pfam01706
447217006688	Flagellar assembly protein FliH; Region: FliH; pfam02108
447217006689	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
447217006690	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
447217006691	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006692	Walker A motif; other site
447217006693	ATP binding site [chemical binding]; other site
447217006694	Walker B motif; other site
447217006695	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
447217006696	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
447217006697	FlgD Ig-like domain; Region: FlgD_ig; cl15790
447217006698	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
447217006699	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
447217006700	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
447217006701	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217006702	Flagellar protein (FlbD); Region: FlbD; cl00683
447217006703	flagellar motor protein MotA; Validated; Region: PRK08124
447217006704	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217006705	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
447217006706	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
447217006707	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217006708	ligand binding site [chemical binding]; other site
447217006709	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217006710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006711	active site
447217006712	phosphorylation site [posttranslational modification]
447217006713	intermolecular recognition site; other site
447217006714	dimerization interface [polypeptide binding]; other site
447217006715	CheB methylesterase; Region: CheB_methylest; pfam01339
447217006716	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217006717	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217006718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006719	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217006720	putative CheA interaction surface; other site
447217006721	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217006722	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217006723	dimerization interface [polypeptide binding]; other site
447217006724	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217006725	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217006726	dimer interface [polypeptide binding]; other site
447217006727	putative CheW interface [polypeptide binding]; other site
447217006728	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217006729	putative binding surface; other site
447217006730	active site
447217006731	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
447217006732	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217006733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006734	ATP binding site [chemical binding]; other site
447217006735	Mg2+ binding site [ion binding]; other site
447217006736	G-X-G motif; other site
447217006737	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217006738	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006740	active site
447217006741	phosphorylation site [posttranslational modification]
447217006742	intermolecular recognition site; other site
447217006743	dimerization interface [polypeptide binding]; other site
447217006744	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
447217006745	putative CheA interaction surface; other site
447217006746	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217006747	dimer interface [polypeptide binding]; other site
447217006748	putative CheW interface [polypeptide binding]; other site
447217006749	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217006750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006751	phosphorylation site [posttranslational modification]
447217006752	intermolecular recognition site; other site
447217006753	CheB methylesterase; Region: CheB_methylest; pfam01339
447217006754	CheD chemotactic sensory transduction; Region: CheD; cl00810
447217006755	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217006756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217006757	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217006758	putative binding surface; other site
447217006759	active site
447217006760	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217006761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006762	ATP binding site [chemical binding]; other site
447217006763	Mg2+ binding site [ion binding]; other site
447217006764	G-X-G motif; other site
447217006765	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217006766	Chemotaxis phosphatase CheX; Region: CheX; cl15816
447217006767	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006769	active site
447217006770	phosphorylation site [posttranslational modification]
447217006771	intermolecular recognition site; other site
447217006772	dimerization interface [polypeptide binding]; other site
447217006773	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006775	active site
447217006776	phosphorylation site [posttranslational modification]
447217006777	intermolecular recognition site; other site
447217006778	dimerization interface [polypeptide binding]; other site
447217006779	HDOD domain; Region: HDOD; pfam08668
447217006780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217006781	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
447217006782	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
447217006783	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
447217006784	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
447217006785	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
447217006786	FliP family; Region: FliP; cl00593
447217006787	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
447217006788	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
447217006789	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
447217006790	type III secretion system protein SpaS; Validated; Region: PRK08156
447217006791	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
447217006792	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
447217006793	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
447217006794	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
447217006795	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
447217006796	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006797	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
447217006798	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006799	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
447217006800	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217006801	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217006802	DNA binding residues [nucleotide binding]
447217006803	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217006804	fagellar hook-basal body proteins; Region: FlgEFG_subfam; TIGR03506
447217006805	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
447217006806	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217006807	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
447217006808	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
447217006809	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
447217006810	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217006811	Flagellar L-ring protein; Region: FlgH; cl00905
447217006812	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
447217006813	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
447217006814	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217006815	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
447217006816	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
447217006817	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
447217006818	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
447217006819	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217006820	flagellin; Provisional; Region: PRK12802
447217006821	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217006822	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
447217006823	flagellar capping protein; Reviewed; Region: fliD; PRK08032
447217006824	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
447217006825	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
447217006826	flagellin; Provisional; Region: PRK12802
447217006827	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
447217006828	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
447217006829	Flagellar protein FliS; Region: FliS; cl00654
447217006830	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
447217006831	putative metal binding site; other site
447217006832	PilZ domain; Region: PilZ; cl01260
447217006833	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217006834	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
447217006835	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217006836	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006837	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
447217006838	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
447217006839	dimer interface [polypeptide binding]; other site
447217006840	putative functional site; other site
447217006841	putative MPT binding site; other site
447217006842	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
447217006843	Helix-turn-helix domains; Region: HTH; cl00088
447217006844	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
447217006845	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006846	Ligand Binding Site [chemical binding]; other site
447217006847	FOG: CBS domain [General function prediction only]; Region: COG0517
447217006848	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803
447217006849	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
447217006850	heme-binding site [chemical binding]; other site
447217006851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217006852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006853	dimer interface [polypeptide binding]; other site
447217006854	phosphorylation site [posttranslational modification]
447217006855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006856	ATP binding site [chemical binding]; other site
447217006857	Mg2+ binding site [ion binding]; other site
447217006858	G-X-G motif; other site
447217006859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006860	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006861	active site
447217006862	phosphorylation site [posttranslational modification]
447217006863	intermolecular recognition site; other site
447217006864	dimerization interface [polypeptide binding]; other site
447217006865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006866	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006867	active site
447217006868	phosphorylation site [posttranslational modification]
447217006869	intermolecular recognition site; other site
447217006870	dimerization interface [polypeptide binding]; other site
447217006871	Response regulator receiver domain; Region: Response_reg; pfam00072
447217006872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006873	active site
447217006874	phosphorylation site [posttranslational modification]
447217006875	intermolecular recognition site; other site
447217006876	dimerization interface [polypeptide binding]; other site
447217006877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217006878	dimer interface [polypeptide binding]; other site
447217006879	phosphorylation site [posttranslational modification]
447217006880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217006881	ATP binding site [chemical binding]; other site
447217006882	Mg2+ binding site [ion binding]; other site
447217006883	G-X-G motif; other site
447217006884	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217006885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217006886	active site
447217006887	phosphorylation site [posttranslational modification]
447217006888	intermolecular recognition site; other site
447217006889	dimerization interface [polypeptide binding]; other site
447217006890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217006891	Walker A motif; other site
447217006892	ATP binding site [chemical binding]; other site
447217006893	Walker B motif; other site
447217006894	arginine finger; other site
447217006895	Helix-turn-helix domains; Region: HTH; cl00088
447217006896	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
447217006897	radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X
447217006898	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217006899	FOG: CBS domain [General function prediction only]; Region: COG0517
447217006900	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217006901	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217006902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217006903	Ligand Binding Site [chemical binding]; other site
447217006904	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
447217006905	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217006906	NAD binding site [chemical binding]; other site
447217006907	catalytic Zn binding site [ion binding]; other site
447217006908	structural Zn binding site [ion binding]; other site
447217006909	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
447217006910	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
447217006911	Isochorismatase family; Region: Isochorismatase; pfam00857
447217006912	catalytic triad [active]
447217006913	metal binding site [ion binding]; metal-binding site
447217006914	conserved cis-peptide bond; other site
447217006915	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
447217006916	generic binding surface I; other site
447217006917	generic binding surface II; other site
447217006918	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
447217006919	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
447217006920	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217006921	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
447217006922	active site
447217006923	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
447217006924	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
447217006925	active site
447217006926	HIGH motif; other site
447217006927	KMSKS motif; other site
447217006928	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
447217006929	anticodon binding site; other site
447217006930	tRNA binding surface [nucleotide binding]; other site
447217006931	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
447217006932	dimer interface [polypeptide binding]; other site
447217006933	putative tRNA-binding site [nucleotide binding]; other site
447217006934	DNA polymerase III, delta subunit; Region: holA; TIGR01128
447217006935	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
447217006936	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217006937	DivIVA protein; Region: DivIVA; pfam05103
447217006938	DivIVA domain; Region: DivI1A_domain; TIGR03544
447217006939	DNA polymerase I; Provisional; Region: PRK05755
447217006940	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
447217006941	active site
447217006942	metal binding site 1 [ion binding]; metal-binding site
447217006943	putative 5' ssDNA interaction site; other site
447217006944	metal binding site 3; metal-binding site
447217006945	metal binding site 2 [ion binding]; metal-binding site
447217006946	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
447217006947	putative DNA binding site [nucleotide binding]; other site
447217006948	putative metal binding site [ion binding]; other site
447217006949	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
447217006950	active site
447217006951	substrate binding site [chemical binding]; other site
447217006952	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
447217006953	active site
447217006954	DNA binding site [nucleotide binding]
447217006955	catalytic site [active]
447217006956	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217006957	phosphopeptide binding site; other site
447217006958	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
447217006959	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
447217006960	dimer interface [polypeptide binding]; other site
447217006961	motif 1; other site
447217006962	active site
447217006963	motif 2; other site
447217006964	motif 3; other site
447217006965	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
447217006966	putative substrate binding site [chemical binding]; other site
447217006967	putative ATP binding site [chemical binding]; other site
447217006968	Recombination protein O N terminal; Region: RecO_N; cl15812
447217006969	DNA repair protein RecO; Region: reco; TIGR00613
447217006970	Recombination protein O C terminal; Region: RecO_C; pfam02565
447217006971	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217006972	TPR repeat; Region: TPR_11; pfam13414
447217006973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217006974	binding surface
447217006975	TPR motif; other site
447217006976	TPR repeat; Region: TPR_11; pfam13414
447217006977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217006978	binding surface
447217006979	TPR motif; other site
447217006980	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
447217006981	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217006982	FeS/SAM binding site; other site
447217006983	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
447217006984	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217006985	catalytic residue [active]
447217006986	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
447217006987	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
447217006988	quinone interaction residues [chemical binding]; other site
447217006989	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
447217006990	active site
447217006991	catalytic residues [active]
447217006992	FMN binding site [chemical binding]; other site
447217006993	substrate binding site [chemical binding]; other site
447217006994	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
447217006995	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217006996	chaperone protein DnaJ; Provisional; Region: PRK14299
447217006997	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217006998	HSP70 interaction site [polypeptide binding]; other site
447217006999	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
447217007000	substrate binding site [polypeptide binding]; other site
447217007001	dimer interface [polypeptide binding]; other site
447217007002	HEAT repeats; Region: HEAT_2; pfam13646
447217007003	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
447217007004	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
447217007005	putative acyl-acceptor binding pocket; other site
447217007006	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
447217007007	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
447217007008	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
447217007009	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
447217007010	active site
447217007011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217007012	Coenzyme A binding pocket [chemical binding]; other site
447217007013	Ycf46; Provisional; Region: ycf46; CHL00195
447217007014	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007015	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217007016	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
447217007017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007018	Walker A motif; other site
447217007019	ATP binding site [chemical binding]; other site
447217007020	Walker B motif; other site
447217007021	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
447217007022	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
447217007023	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
447217007024	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
447217007025	dimer interface [polypeptide binding]; other site
447217007026	substrate binding site [chemical binding]; other site
447217007027	metal binding sites [ion binding]; metal-binding site
447217007028	serine O-acetyltransferase; Region: cysE; TIGR01172
447217007029	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
447217007030	trimer interface [polypeptide binding]; other site
447217007031	active site
447217007032	substrate binding site [chemical binding]; other site
447217007033	CoA binding site [chemical binding]; other site
447217007034	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217007035	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217007036	dimer interface [polypeptide binding]; other site
447217007037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007038	catalytic residue [active]
447217007039	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
447217007040	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
447217007041	GIY-YIG motif/motif A; other site
447217007042	active site
447217007043	catalytic site [active]
447217007044	putative DNA binding site [nucleotide binding]; other site
447217007045	metal binding site [ion binding]; metal-binding site
447217007046	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
447217007047	Cytochrome c [Energy production and conversion]; Region: COG3258
447217007048	Cytochrome c; Region: Cytochrom_C; cl11414
447217007049	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007050	dimerization interface [polypeptide binding]; other site
447217007051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007052	dimer interface [polypeptide binding]; other site
447217007053	phosphorylation site [posttranslational modification]
447217007054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007055	ATP binding site [chemical binding]; other site
447217007056	Mg2+ binding site [ion binding]; other site
447217007057	G-X-G motif; other site
447217007058	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217007059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007060	active site
447217007061	phosphorylation site [posttranslational modification]
447217007062	intermolecular recognition site; other site
447217007063	dimerization interface [polypeptide binding]; other site
447217007064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007065	Walker A motif; other site
447217007066	ATP binding site [chemical binding]; other site
447217007067	Walker B motif; other site
447217007068	arginine finger; other site
447217007069	excinuclease ABC subunit B; Provisional; Region: PRK05298
447217007070	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217007071	ATP binding site [chemical binding]; other site
447217007072	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217007073	nucleotide binding region [chemical binding]; other site
447217007074	ATP-binding site [chemical binding]; other site
447217007075	Ultra-violet resistance protein B; Region: UvrB; pfam12344
447217007076	UvrB/uvrC motif; Region: UVR; pfam02151
447217007077	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217007078	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217007079	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217007080	DNA-binding site [nucleotide binding]; DNA binding site
447217007081	RNA-binding motif; other site
447217007082	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
447217007083	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
447217007084	active site
447217007085	HIGH motif; other site
447217007086	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
447217007087	KMSKS motif; other site
447217007088	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
447217007089	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217007090	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
447217007091	active site
447217007092	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
447217007093	homotrimer interaction site [polypeptide binding]; other site
447217007094	zinc binding site [ion binding]; other site
447217007095	CDP-binding sites; other site
447217007096	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
447217007097	Competence protein; Region: Competence; cl00471
447217007098	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217007099	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217007100	phosphopeptide binding site; other site
447217007101	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
447217007102	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
447217007103	GDP-binding site [chemical binding]; other site
447217007104	ACT binding site; other site
447217007105	IMP binding site; other site
447217007106	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
447217007107	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
447217007108	dimer interface [polypeptide binding]; other site
447217007109	motif 1; other site
447217007110	motif 2; other site
447217007111	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217007112	active site
447217007113	motif 3; other site
447217007114	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
447217007115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007116	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
447217007117	putative L-serine binding site [chemical binding]; other site
447217007118	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
447217007119	Helix-turn-helix domains; Region: HTH; cl00088
447217007120	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
447217007121	AMIN domain; Region: AMIN; pfam11741
447217007122	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
447217007123	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217007124	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
447217007125	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
447217007126	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217007127	ligand binding site [chemical binding]; other site
447217007128	flexible hinge region; other site
447217007129	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
447217007130	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
447217007131	dimerization interface [polypeptide binding]; other site
447217007132	putative ATP binding site [chemical binding]; other site
447217007133	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
447217007134	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
447217007135	active site
447217007136	substrate binding site [chemical binding]; other site
447217007137	cosubstrate binding site; other site
447217007138	catalytic site [active]
447217007139	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217007140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007141	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
447217007142	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
447217007143	putative active site [active]
447217007144	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
447217007145	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
447217007146	active site
447217007147	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14182
447217007148	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
447217007149	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
447217007150	homodimer interface [polypeptide binding]; other site
447217007151	NADP binding site [chemical binding]; other site
447217007152	substrate binding site [chemical binding]; other site
447217007153	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217007154	active site
447217007155	metal binding site [ion binding]; metal-binding site
447217007156	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
447217007157	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
447217007158	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217007159	lipoyl attachment site [posttranslational modification]; other site
447217007160	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
447217007161	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007162	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007163	catalytic residue [active]
447217007164	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
447217007165	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007166	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007167	catalytic residue [active]
447217007168	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
447217007169	active site
447217007170	dimer interfaces [polypeptide binding]; other site
447217007171	catalytic residues [active]
447217007172	Gram-negative bacterial tonB protein; Region: TonB; cl10048
447217007173	Transglycosylase; Region: Transgly; cl07896
447217007174	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
447217007175	rRNA binding site [nucleotide binding]; other site
447217007176	predicted 30S ribosome binding site; other site
447217007177	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217007178	DNA-binding site [nucleotide binding]; DNA binding site
447217007179	RNA-binding motif; other site
447217007180	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
447217007181	YceG-like family; Region: YceG; pfam02618
447217007182	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
447217007183	dimerization interface [polypeptide binding]; other site
447217007184	PrkA AAA domain; Region: AAA_PrkA; smart00763
447217007185	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
447217007186	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217007187	SpoVR like protein; Region: SpoVR; pfam04293
447217007188	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
447217007189	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217007190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007191	putative active site [active]
447217007192	heme pocket [chemical binding]; other site
447217007193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217007194	helicase 45; Provisional; Region: PTZ00424
447217007195	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
447217007196	ATP binding site [chemical binding]; other site
447217007197	Mg++ binding site [ion binding]; other site
447217007198	motif III; other site
447217007199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217007200	nucleotide binding region [chemical binding]; other site
447217007201	ATP-binding site [chemical binding]; other site
447217007202	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
447217007203	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
447217007204	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217007205	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
447217007206	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
447217007207	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
447217007208	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
447217007209	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217007210	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
447217007211	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217007212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217007213	motif II; other site
447217007214	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
447217007215	classical (c) SDRs; Region: SDR_c; cd05233
447217007216	NAD(P) binding site [chemical binding]; other site
447217007217	active site
447217007218	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
447217007219	dimer interface [polypeptide binding]; other site
447217007220	[2Fe-2S] cluster binding site [ion binding]; other site
447217007221	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
447217007222	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
447217007223	Protein of unknown function (DUF419); Region: DUF419; cl15265
447217007224	Leucine carboxyl methyltransferase; Region: LCM; cl01306
447217007225	TPR repeat; Region: TPR_11; pfam13414
447217007226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007227	binding surface
447217007228	TPR motif; other site
447217007229	Protein of unknown function (DUF419); Region: DUF419; cl15265
447217007230	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
447217007231	putative hydrophobic ligand binding site [chemical binding]; other site
447217007232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217007233	dimerization interface [polypeptide binding]; other site
447217007234	putative DNA binding site [nucleotide binding]; other site
447217007235	putative Zn2+ binding site [ion binding]; other site
447217007236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217007237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217007238	TPR repeat; Region: TPR_11; pfam13414
447217007239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007240	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
447217007241	NAD(P) binding site [chemical binding]; other site
447217007242	active site
447217007243	PAS domain S-box; Region: sensory_box; TIGR00229
447217007244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217007245	putative active site [active]
447217007246	heme pocket [chemical binding]; other site
447217007247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217007248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007249	ATP binding site [chemical binding]; other site
447217007250	Mg2+ binding site [ion binding]; other site
447217007251	G-X-G motif; other site
447217007252	ATP synthase subunit D; Region: ATP-synt_D; cl00613
447217007253	V-type ATP synthase subunit B; Provisional; Region: PRK04196
447217007254	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
447217007255	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
447217007256	Walker A motif homologous position; other site
447217007257	Walker B motif; other site
447217007258	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217007259	V-type ATP synthase subunit A; Provisional; Region: PRK04192
447217007260	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
447217007261	Walker A motif/ATP binding site; other site
447217007262	Walker B motif; other site
447217007263	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217007264	ATP synthase subunit C; Region: ATP-synt_C; cl00466
447217007265	V-type ATP synthase subunit I; Validated; Region: PRK05771
447217007266	V-type ATP synthase subunit I; Validated; Region: PRK05771
447217007267	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
447217007268	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217007269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007270	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217007271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007272	dimerization interface [polypeptide binding]; other site
447217007273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217007274	dimer interface [polypeptide binding]; other site
447217007275	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
447217007276	putative CheW interface [polypeptide binding]; other site
447217007277	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
447217007278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007279	ATP binding site [chemical binding]; other site
447217007280	Mg2+ binding site [ion binding]; other site
447217007281	G-X-G motif; other site
447217007282	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007284	active site
447217007285	phosphorylation site [posttranslational modification]
447217007286	intermolecular recognition site; other site
447217007287	dimerization interface [polypeptide binding]; other site
447217007288	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
447217007289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007290	active site
447217007291	phosphorylation site [posttranslational modification]
447217007292	intermolecular recognition site; other site
447217007293	CheB methylesterase; Region: CheB_methylest; pfam01339
447217007294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007295	dimer interface [polypeptide binding]; other site
447217007296	phosphorylation site [posttranslational modification]
447217007297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007298	ATP binding site [chemical binding]; other site
447217007299	Mg2+ binding site [ion binding]; other site
447217007300	G-X-G motif; other site
447217007301	Helix-turn-helix domains; Region: HTH; cl00088
447217007302	multidrug resistance protein MdtN; Provisional; Region: PRK10476
447217007303	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217007304	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217007305	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217007306	Outer membrane efflux protein; Region: OEP; pfam02321
447217007307	Helix-turn-helix domains; Region: HTH; cl00088
447217007308	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217007309	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217007310	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
447217007311	nudix motif; other site
447217007312	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
447217007313	Fe-S cluster binding site [ion binding]; other site
447217007314	active site
447217007315	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
447217007316	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
447217007317	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
447217007318	catalytic site [active]
447217007319	G-X2-G-X-G-K; other site
447217007320	hypothetical protein; Provisional; Region: PRK11820
447217007321	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
447217007322	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
447217007323	Trm112p-like protein; Region: Trm112p; cl01066
447217007324	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217007325	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
447217007326	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217007327	active site
447217007328	nucleotide binding site [chemical binding]; other site
447217007329	HIGH motif; other site
447217007330	KMSKS motif; other site
447217007331	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
447217007332	putative ribose interaction site [chemical binding]; other site
447217007333	putative ADP binding site [chemical binding]; other site
447217007334	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
447217007335	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
447217007336	putative acyl-acceptor binding pocket; other site
447217007337	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
447217007338	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
447217007339	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
447217007340	putative active site [active]
447217007341	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
447217007342	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
447217007343	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217007344	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
447217007345	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
447217007346	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
447217007347	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
447217007348	Walker A/P-loop; other site
447217007349	ATP binding site [chemical binding]; other site
447217007350	Q-loop/lid; other site
447217007351	ABC transporter signature motif; other site
447217007352	Walker B; other site
447217007353	D-loop; other site
447217007354	H-loop/switch region; other site
447217007355	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007356	elongation factor G; Reviewed; Region: PRK12740
447217007357	G1 box; other site
447217007358	GTP/Mg2+ binding site [chemical binding]; other site
447217007359	G2 box; other site
447217007360	Switch I region; other site
447217007361	G3 box; other site
447217007362	Switch II region; other site
447217007363	G4 box; other site
447217007364	G5 box; other site
447217007365	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
447217007366	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
447217007367	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
447217007368	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
447217007369	AMP-binding enzyme; Region: AMP-binding; cl15778
447217007370	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
447217007371	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
447217007372	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
447217007373	Cytochrome c; Region: Cytochrom_C; cl11414
447217007374	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007375	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007376	catalytic residue [active]
447217007377	MarC family integral membrane protein; Region: MarC; cl00919
447217007378	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
447217007379	Ligand binding site; other site
447217007380	Putative Catalytic site; other site
447217007381	DXD motif; other site
447217007382	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
447217007383	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
447217007384	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217007385	dimerization interface [polypeptide binding]; other site
447217007386	putative DNA binding site [nucleotide binding]; other site
447217007387	putative Zn2+ binding site [ion binding]; other site
447217007388	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217007389	active site residue [active]
447217007390	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
447217007391	4Fe-4S binding domain; Region: Fer4; cl02805
447217007392	4Fe-4S binding domain; Region: Fer4; cl02805
447217007393	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217007394	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217007395	thiosulfate reductase PhsA; Provisional; Region: PRK15488
447217007396	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
447217007397	putative [Fe4-S4] binding site [ion binding]; other site
447217007398	putative molybdopterin cofactor binding site [chemical binding]; other site
447217007399	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
447217007400	molybdopterin cofactor binding site; other site
447217007401	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
447217007402	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
447217007403	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217007404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007405	dimer interface [polypeptide binding]; other site
447217007406	phosphorylation site [posttranslational modification]
447217007407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007408	ATP binding site [chemical binding]; other site
447217007409	Mg2+ binding site [ion binding]; other site
447217007410	G-X-G motif; other site
447217007411	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007413	active site
447217007414	phosphorylation site [posttranslational modification]
447217007415	intermolecular recognition site; other site
447217007416	dimerization interface [polypeptide binding]; other site
447217007417	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
447217007418	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
447217007419	putative Iron-sulfur protein interface [polypeptide binding]; other site
447217007420	proximal heme binding site [chemical binding]; other site
447217007421	distal heme binding site [chemical binding]; other site
447217007422	putative dimer interface [polypeptide binding]; other site
447217007423	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
447217007424	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007425	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217007426	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
447217007427	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
447217007428	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
447217007429	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217007430	putative ADP-binding pocket [chemical binding]; other site
447217007431	O-Antigen ligase; Region: Wzy_C; cl04850
447217007432	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
447217007433	putative homodimer interface [polypeptide binding]; other site
447217007434	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
447217007435	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007436	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007437	putative active site [active]
447217007438	putative metal binding site [ion binding]; other site
447217007439	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217007440	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007441	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217007442	catalytic residue [active]
447217007443	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217007444	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217007445	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
447217007446	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
447217007447	phosphate binding site [ion binding]; other site
447217007448	putative substrate binding pocket [chemical binding]; other site
447217007449	dimer interface [polypeptide binding]; other site
447217007450	Bacterial sugar transferase; Region: Bac_transf; cl00939
447217007451	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
447217007452	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
447217007453	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217007454	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
447217007455	SLBB domain; Region: SLBB; pfam10531
447217007456	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217007457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007458	active site
447217007459	phosphorylation site [posttranslational modification]
447217007460	intermolecular recognition site; other site
447217007461	dimerization interface [polypeptide binding]; other site
447217007462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007463	Walker A motif; other site
447217007464	ATP binding site [chemical binding]; other site
447217007465	Walker B motif; other site
447217007466	arginine finger; other site
447217007467	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217007468	active site residue [active]
447217007469	Stage II sporulation protein; Region: SpoIID; pfam08486
447217007470	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
447217007471	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
447217007472	homodimer interface [polypeptide binding]; other site
447217007473	substrate-cofactor binding pocket; other site
447217007474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007475	catalytic residue [active]
447217007476	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217007477	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217007478	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217007479	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217007480	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217007481	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217007482	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217007483	Walker A/P-loop; other site
447217007484	ATP binding site [chemical binding]; other site
447217007485	Q-loop/lid; other site
447217007486	ABC transporter signature motif; other site
447217007487	Walker B; other site
447217007488	D-loop; other site
447217007489	H-loop/switch region; other site
447217007490	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217007491	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217007492	FtsX-like permease family; Region: FtsX; cl15850
447217007493	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217007494	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217007495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007496	NAD(P) binding site [chemical binding]; other site
447217007497	active site
447217007498	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217007499	putative catalytic site [active]
447217007500	putative metal binding site [ion binding]; other site
447217007501	putative phosphate binding site [ion binding]; other site
447217007502	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
447217007503	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
447217007504	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
447217007505	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217007506	dimer interface [polypeptide binding]; other site
447217007507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007508	catalytic residue [active]
447217007509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217007510	S-adenosylmethionine binding site [chemical binding]; other site
447217007511	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217007512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217007513	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
447217007514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217007515	Low affinity iron permease; Region: Iron_permease; cl12096
447217007516	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
447217007517	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
447217007518	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217007519	Ligand Binding Site [chemical binding]; other site
447217007520	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
447217007521	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
447217007522	FAD binding site [chemical binding]; other site
447217007523	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
447217007524	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
447217007525	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
447217007526	putative catalytic site [active]
447217007527	putative metal binding site [ion binding]; other site
447217007528	putative phosphate binding site [ion binding]; other site
447217007529	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
447217007530	G1 box; other site
447217007531	GTP/Mg2+ binding site [chemical binding]; other site
447217007532	Switch I region; other site
447217007533	G2 box; other site
447217007534	G3 box; other site
447217007535	Switch II region; other site
447217007536	G4 box; other site
447217007537	G5 box; other site
447217007538	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217007539	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
447217007540	dephospho-CoA kinase; Region: TIGR00152
447217007541	CoA-binding site [chemical binding]; other site
447217007542	ATP-binding [chemical binding]; other site
447217007543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007544	NAD(P) binding site [chemical binding]; other site
447217007545	active site
447217007546	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217007547	active site 2 [active]
447217007548	active site 1 [active]
447217007549	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
447217007550	active site
447217007551	catalytic site [active]
447217007552	TPR repeat; Region: TPR_11; pfam13414
447217007553	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217007554	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
447217007555	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
447217007556	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217007557	HSP70 interaction site [polypeptide binding]; other site
447217007558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217007559	ornithine carbamoyltransferase; Provisional; Region: PRK00779
447217007560	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
447217007561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007562	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217007563	inhibitor-cofactor binding pocket; inhibition site
447217007564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007565	catalytic residue [active]
447217007566	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
447217007567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007568	Walker A motif; other site
447217007569	ATP binding site [chemical binding]; other site
447217007570	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007571	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217007572	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
447217007573	active site
447217007574	HslU subunit interaction site [polypeptide binding]; other site
447217007575	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
447217007576	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
447217007577	DNA binding site [nucleotide binding]
447217007578	Int/Topo IB signature motif; other site
447217007579	active site
447217007580	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
447217007581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007582	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217007583	DNA topoisomerase I; Validated; Region: PRK06599
447217007584	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
447217007585	active site
447217007586	interdomain interaction site; other site
447217007587	putative metal-binding site [ion binding]; other site
447217007588	nucleotide binding site [chemical binding]; other site
447217007589	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
447217007590	domain I; other site
447217007591	DNA binding groove [nucleotide binding]
447217007592	phosphate binding site [ion binding]; other site
447217007593	domain II; other site
447217007594	domain III; other site
447217007595	nucleotide binding site [chemical binding]; other site
447217007596	catalytic site [active]
447217007597	domain IV; other site
447217007598	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007599	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007600	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
447217007601	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
447217007602	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
447217007603	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
447217007604	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
447217007605	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
447217007606	two component system sensor kinase SsrA; Provisional; Region: PRK15347
447217007607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217007608	dimerization interface [polypeptide binding]; other site
447217007609	GAF domain; Region: GAF_2; pfam13185
447217007610	GAF domain; Region: GAF; cl15785
447217007611	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217007612	metal binding site [ion binding]; metal-binding site
447217007613	active site
447217007614	I-site; other site
447217007615	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007617	active site
447217007618	phosphorylation site [posttranslational modification]
447217007619	intermolecular recognition site; other site
447217007620	dimerization interface [polypeptide binding]; other site
447217007621	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
447217007622	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
447217007623	active site
447217007624	metal binding site [ion binding]; metal-binding site
447217007625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217007626	Walker A motif; other site
447217007627	ATP binding site [chemical binding]; other site
447217007628	Walker B motif; other site
447217007629	arginine finger; other site
447217007630	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
447217007631	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
447217007632	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
447217007633	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217007634	putative ADP-binding pocket [chemical binding]; other site
447217007635	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217007636	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
447217007637	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
447217007638	catalytic residues [active]
447217007639	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
447217007640	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
447217007641	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007642	Walker A motif; other site
447217007643	ATP binding site [chemical binding]; other site
447217007644	Walker B motif; other site
447217007645	PilZ domain; Region: PilZ; cl01260
447217007646	peptide chain release factor 2; Validated; Region: prfB; PRK00578
447217007647	RF-1 domain; Region: RF-1; cl02875
447217007648	RF-1 domain; Region: RF-1; cl02875
447217007649	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
447217007650	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
447217007651	putative active site [active]
447217007652	catalytic triad [active]
447217007653	putative dimer interface [polypeptide binding]; other site
447217007654	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
447217007655	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
447217007656	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217007657	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
447217007658	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007659	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217007660	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
447217007661	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217007662	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
447217007663	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
447217007664	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
447217007665	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
447217007666	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
447217007667	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
447217007668	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
447217007669	HIGH motif; other site
447217007670	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
447217007671	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
447217007672	active site
447217007673	KMSKS motif; other site
447217007674	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
447217007675	tRNA binding surface [nucleotide binding]; other site
447217007676	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
447217007677	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
447217007678	putative dimer interface [polypeptide binding]; other site
447217007679	putative anticodon binding site; other site
447217007680	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
447217007681	homodimer interface [polypeptide binding]; other site
447217007682	motif 1; other site
447217007683	motif 2; other site
447217007684	active site
447217007685	motif 3; other site
447217007686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007687	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007688	active site
447217007689	phosphorylation site [posttranslational modification]
447217007690	intermolecular recognition site; other site
447217007691	dimerization interface [polypeptide binding]; other site
447217007692	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
447217007693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007694	active site
447217007695	phosphorylation site [posttranslational modification]
447217007696	intermolecular recognition site; other site
447217007697	dimerization interface [polypeptide binding]; other site
447217007698	CheB methylesterase; Region: CheB_methylest; pfam01339
447217007699	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
447217007700	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007701	HEAT repeats; Region: HEAT_2; pfam13646
447217007702	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217007703	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217007704	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
447217007705	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
447217007706	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007707	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217007708	putative binding surface; other site
447217007709	active site
447217007710	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217007711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007712	ATP binding site [chemical binding]; other site
447217007713	Mg2+ binding site [ion binding]; other site
447217007714	G-X-G motif; other site
447217007715	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
447217007716	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
447217007717	putative RNA binding site [nucleotide binding]; other site
447217007718	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
447217007719	homopentamer interface [polypeptide binding]; other site
447217007720	active site
447217007721	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
447217007722	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
447217007723	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
447217007724	dimerization interface [polypeptide binding]; other site
447217007725	active site
447217007726	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
447217007727	Lumazine binding domain; Region: Lum_binding; pfam00677
447217007728	Lumazine binding domain; Region: Lum_binding; pfam00677
447217007729	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
447217007730	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
447217007731	catalytic motif [active]
447217007732	Zn binding site [ion binding]; other site
447217007733	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217007734	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
447217007735	ATP cone domain; Region: ATP-cone; pfam03477
447217007736	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
447217007737	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
447217007738	dimer interface [polypeptide binding]; other site
447217007739	glycine-pyridoxal phosphate binding site [chemical binding]; other site
447217007740	active site
447217007741	folate binding site [chemical binding]; other site
447217007742	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
447217007743	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
447217007744	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
447217007745	dimer interface [polypeptide binding]; other site
447217007746	active site
447217007747	Phosphopantetheine attachment site; Region: PP-binding; cl09936
447217007748	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217007749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007750	NAD(P) binding site [chemical binding]; other site
447217007751	active site
447217007752	Acyl transferase domain; Region: Acyl_transf_1; cl08282
447217007753	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
447217007754	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
447217007755	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
447217007756	dimer interface [polypeptide binding]; other site
447217007757	active site
447217007758	CoA binding pocket [chemical binding]; other site
447217007759	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
447217007760	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
447217007761	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
447217007762	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
447217007763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007764	active site
447217007765	phosphorylation site [posttranslational modification]
447217007766	intermolecular recognition site; other site
447217007767	dimerization interface [polypeptide binding]; other site
447217007768	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217007769	DNA binding residues [nucleotide binding]
447217007770	dimerization interface [polypeptide binding]; other site
447217007771	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
447217007772	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
447217007773	GIY-YIG motif/motif A; other site
447217007774	active site
447217007775	catalytic site [active]
447217007776	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
447217007777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007778	NAD(P) binding site [chemical binding]; other site
447217007779	active site
447217007780	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
447217007781	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007782	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
447217007783	putative active site [active]
447217007784	putative metal binding site [ion binding]; other site
447217007785	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217007786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007787	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217007788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007789	NAD(P) binding site [chemical binding]; other site
447217007790	active site
447217007791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007792	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
447217007793	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
447217007794	putative ADP-binding pocket [chemical binding]; other site
447217007795	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
447217007796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007797	Bacterial sugar transferase; Region: Bac_transf; cl00939
447217007798	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
447217007799	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217007800	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
447217007801	Phosphopantetheine attachment site; Region: PP-binding; cl09936
447217007802	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
447217007803	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
447217007804	active site
447217007805	dimer interface [polypeptide binding]; other site
447217007806	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
447217007807	Ligand Binding Site [chemical binding]; other site
447217007808	Molecular Tunnel; other site
447217007809	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
447217007810	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
447217007811	homodimer interface [polypeptide binding]; other site
447217007812	NAD binding pocket [chemical binding]; other site
447217007813	ATP binding pocket [chemical binding]; other site
447217007814	Mg binding site [ion binding]; other site
447217007815	active-site loop [active]
447217007816	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217007817	AMP-binding enzyme; Region: AMP-binding; cl15778
447217007818	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217007819	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217007820	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
447217007821	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217007822	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
447217007823	trimer interface [polypeptide binding]; other site
447217007824	active site
447217007825	substrate binding site [chemical binding]; other site
447217007826	CoA binding site [chemical binding]; other site
447217007827	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
447217007828	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217007829	active site
447217007830	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
447217007831	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217007832	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
447217007833	MatE; Region: MatE; cl10513
447217007834	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
447217007835	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217007836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007837	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
447217007838	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
447217007839	Probable Catalytic site; other site
447217007840	metal-binding site
447217007841	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217007842	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
447217007843	Probable Catalytic site; other site
447217007844	metal-binding site
447217007845	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
447217007846	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
447217007847	active site
447217007848	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
447217007849	Ligand Binding Site [chemical binding]; other site
447217007850	Molecular Tunnel; other site
447217007851	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217007852	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
447217007853	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
447217007854	inhibitor-cofactor binding pocket; inhibition site
447217007855	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217007856	catalytic residue [active]
447217007857	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
447217007858	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
447217007859	OpgC protein; Region: OpgC_C; cl00792
447217007860	Acyltransferase family; Region: Acyl_transf_3; pfam01757
447217007861	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
447217007862	putative ADP-binding pocket [chemical binding]; other site
447217007863	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
447217007864	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
447217007865	FAD binding pocket [chemical binding]; other site
447217007866	FAD binding motif [chemical binding]; other site
447217007867	phosphate binding motif [ion binding]; other site
447217007868	beta-alpha-beta structure motif; other site
447217007869	NAD binding pocket [chemical binding]; other site
447217007870	Iron coordination center [ion binding]; other site
447217007871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007872	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217007873	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
447217007874	diiron binding motif [ion binding]; other site
447217007875	PilZ domain; Region: PilZ; cl01260
447217007876	Rhomboid family; Region: Rhomboid; cl11446
447217007877	RNA polymerase sigma factor; Provisional; Region: PRK12518
447217007878	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217007879	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217007880	active site
447217007881	ATP binding site [chemical binding]; other site
447217007882	substrate binding site [chemical binding]; other site
447217007883	activation loop (A-loop); other site
447217007884	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
447217007885	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217007886	putative NAD(P) binding site [chemical binding]; other site
447217007887	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
447217007888	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
447217007889	cofactor binding site; other site
447217007890	metal binding site [ion binding]; metal-binding site
447217007891	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217007892	ABC transporter; Region: ABC_tran; pfam00005
447217007893	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217007894	Response regulator receiver domain; Region: Response_reg; pfam00072
447217007895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217007896	active site
447217007897	phosphorylation site [posttranslational modification]
447217007898	intermolecular recognition site; other site
447217007899	dimerization interface [polypeptide binding]; other site
447217007900	Sodium:solute symporter family; Region: SSF; cl00456
447217007901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217007902	dimer interface [polypeptide binding]; other site
447217007903	phosphorylation site [posttranslational modification]
447217007904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007905	ATP binding site [chemical binding]; other site
447217007906	Mg2+ binding site [ion binding]; other site
447217007907	G-X-G motif; other site
447217007908	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
447217007909	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
447217007910	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
447217007911	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
447217007912	LabA_like proteins; Region: LabA_like/DUF88; cl10034
447217007913	putative metal binding site [ion binding]; other site
447217007914	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
447217007915	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
447217007916	short chain dehydrogenase; Provisional; Region: PRK06701
447217007917	NAD binding site [chemical binding]; other site
447217007918	metal binding site [ion binding]; metal-binding site
447217007919	active site
447217007920	TPR repeat; Region: TPR_11; pfam13414
447217007921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007922	binding surface
447217007923	TPR motif; other site
447217007924	TPR repeat; Region: TPR_11; pfam13414
447217007925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217007926	binding surface
447217007927	TPR motif; other site
447217007928	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217007929	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
447217007930	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
447217007931	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
447217007932	Walker A motif; other site
447217007933	hexamer interface [polypeptide binding]; other site
447217007934	ATP binding site [chemical binding]; other site
447217007935	Walker B motif; other site
447217007936	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
447217007937	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217007938	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
447217007939	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
447217007940	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
447217007941	SAF domain; Region: SAF; cl00555
447217007942	TadE-like protein; Region: TadE; cl10688
447217007943	Flp/Fap pilin component; Region: Flp_Fap; cl01585
447217007944	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
447217007945	active site
447217007946	catalytic site [active]
447217007947	substrate binding site [chemical binding]; other site
447217007948	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
447217007949	DNA topoisomerase VI subunit A; Provisional; Region: PRK04342
447217007950	Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406
447217007951	TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223
447217007952	active site
447217007953	metal binding site [ion binding]; metal-binding site
447217007954	interdomain interaction site; other site
447217007955	DNA topoisomerase VI subunit B; Validated; Region: PRK04184
447217007956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217007957	ATP binding site [chemical binding]; other site
447217007958	Mg2+ binding site [ion binding]; other site
447217007959	G-X-G motif; other site
447217007960	TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823
447217007961	anchoring element; other site
447217007962	dimer interface [polypeptide binding]; other site
447217007963	ATP binding site [chemical binding]; other site
447217007964	Peptidase family M48; Region: Peptidase_M48; cl12018
447217007965	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217007966	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
447217007967	putative NAD(P) binding site [chemical binding]; other site
447217007968	structural Zn binding site [ion binding]; other site
447217007969	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
447217007970	catalytic triad [active]
447217007971	Transposase domain (DUF772); Region: DUF772; cl15789
447217007972	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217007973	Transposase domain (DUF772); Region: DUF772; cl15789
447217007974	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
447217007975	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
447217007976	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
447217007977	EamA-like transporter family; Region: EamA; cl01037
447217007978	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
447217007979	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
447217007980	4Fe-4S binding domain; Region: Fer4; cl02805
447217007981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007983	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
447217007984	Peptidase family M54; Region: Peptidase_M54; cl00835
447217007985	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
447217007986	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
447217007987	nickel binding site [ion binding]; other site
447217007988	Flagellin N-methylase; Region: FliB; cl00497
447217007989	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
447217007990	Cysteine-rich domain; Region: CCG; pfam02754
447217007991	Cysteine-rich domain; Region: CCG; pfam02754
447217007992	FAD binding domain; Region: FAD_binding_4; pfam01565
447217007993	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217007994	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
447217007995	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
447217007996	FAD binding domain; Region: FAD_binding_4; pfam01565
447217007997	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217007998	short chain dehydrogenase; Provisional; Region: PRK07041
447217007999	NAD(P) binding site [chemical binding]; other site
447217008000	active site
447217008001	Helix-turn-helix domains; Region: HTH; cl00088
447217008002	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273
447217008003	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008004	putative NAD(P) binding site [chemical binding]; other site
447217008005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
447217008006	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
447217008007	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008008	Helix-turn-helix domains; Region: HTH; cl00088
447217008009	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
447217008010	rRNA binding site [nucleotide binding]; other site
447217008011	predicted 30S ribosome binding site; other site
447217008012	Helix-turn-helix domains; Region: HTH; cl00088
447217008013	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
447217008014	homotrimer interaction site [polypeptide binding]; other site
447217008015	putative active site [active]
447217008016	Helix-turn-helix domains; Region: HTH; cl00088
447217008017	DNA binding site [nucleotide binding]
447217008018	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217008019	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217008020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008021	S-adenosylmethionine binding site [chemical binding]; other site
447217008022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008023	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217008024	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217008025	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217008026	active site
447217008027	metal binding site [ion binding]; metal-binding site
447217008028	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217008029	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
447217008030	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
447217008031	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
447217008032	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
447217008033	catalytic core [active]
447217008034	Cupin domain; Region: Cupin_2; cl09118
447217008035	phosphate acetyltransferase; Reviewed; Region: PRK05632
447217008036	DRTGG domain; Region: DRTGG; cl12147
447217008037	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
447217008038	Acetokinase family; Region: Acetate_kinase; cl01029
447217008039	propionate/acetate kinase; Provisional; Region: PRK12379
447217008040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008041	NAD(P) binding site [chemical binding]; other site
447217008042	active site
447217008043	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
447217008044	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217008045	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
447217008046	Cytochrome c552; Region: Cytochrom_C552; pfam02335
447217008047	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
447217008048	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
447217008049	AMP-binding enzyme; Region: AMP-binding; cl15778
447217008050	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
447217008051	active site
447217008052	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
447217008053	active site
447217008054	catalytic site [active]
447217008055	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217008056	Protein of unknown function, DUF488; Region: DUF488; cl01246
447217008057	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
447217008058	putative peptidoglycan binding site; other site
447217008059	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
447217008060	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
447217008061	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
447217008062	dimer interface [polypeptide binding]; other site
447217008063	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217008064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008065	active site
447217008066	phosphorylation site [posttranslational modification]
447217008067	intermolecular recognition site; other site
447217008068	dimerization interface [polypeptide binding]; other site
447217008069	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217008070	DNA binding site [nucleotide binding]
447217008071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217008072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008073	dimer interface [polypeptide binding]; other site
447217008074	phosphorylation site [posttranslational modification]
447217008075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008076	ATP binding site [chemical binding]; other site
447217008077	G-X-G motif; other site
447217008078	Spherulation-specific family 4; Region: Spherulin4; pfam12138
447217008079	Helix-turn-helix domains; Region: HTH; cl00088
447217008080	Amidase; Region: Amidase; cl11426
447217008081	Amidase; Region: Amidase; cl11426
447217008082	Helix-turn-helix domains; Region: HTH; cl00088
447217008083	PgaD-like protein; Region: PgaD; cl14676
447217008084	N-glycosyltransferase; Provisional; Region: PRK11204
447217008085	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
447217008086	DXD motif; other site
447217008087	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
447217008088	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
447217008089	putative active site [active]
447217008090	putative metal binding site [ion binding]; other site
447217008091	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217008092	Peptidase family M48; Region: Peptidase_M48; cl12018
447217008093	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
447217008094	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
447217008095	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
447217008096	ATP binding site [chemical binding]; other site
447217008097	substrate interface [chemical binding]; other site
447217008098	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
447217008099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008100	Walker A motif; other site
447217008101	ATP binding site [chemical binding]; other site
447217008102	Walker B motif; other site
447217008103	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
447217008104	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
447217008105	4Fe-4S binding domain; Region: Fer4; cl02805
447217008106	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
447217008107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008108	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217008109	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
447217008110	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
447217008111	putative Iron-sulfur protein interface [polypeptide binding]; other site
447217008112	proximal heme binding site [chemical binding]; other site
447217008113	distal heme binding site [chemical binding]; other site
447217008114	putative dimer interface [polypeptide binding]; other site
447217008115	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217008116	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
447217008117	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
447217008118	PA/protease or protease-like domain interface [polypeptide binding]; other site
447217008119	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
447217008120	Zn binding site [ion binding]; other site
447217008121	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217008122	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217008123	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217008124	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217008125	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
447217008126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008127	adaptive-response sensory kinase; Validated; Region: PRK09303
447217008128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008129	dimer interface [polypeptide binding]; other site
447217008130	phosphorylation site [posttranslational modification]
447217008131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008132	ATP binding site [chemical binding]; other site
447217008133	Mg2+ binding site [ion binding]; other site
447217008134	G-X-G motif; other site
447217008135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008136	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008137	active site
447217008138	phosphorylation site [posttranslational modification]
447217008139	intermolecular recognition site; other site
447217008140	dimerization interface [polypeptide binding]; other site
447217008141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008142	dimer interface [polypeptide binding]; other site
447217008143	phosphorylation site [posttranslational modification]
447217008144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008145	ATP binding site [chemical binding]; other site
447217008146	Mg2+ binding site [ion binding]; other site
447217008147	G-X-G motif; other site
447217008148	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008150	active site
447217008151	phosphorylation site [posttranslational modification]
447217008152	intermolecular recognition site; other site
447217008153	dimerization interface [polypeptide binding]; other site
447217008154	circadian clock protein KaiC; Reviewed; Region: PRK09302
447217008155	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008156	Walker A motif; other site
447217008157	ATP binding site [chemical binding]; other site
447217008158	Walker B motif; other site
447217008159	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008160	Walker A motif; other site
447217008161	ATP binding site [chemical binding]; other site
447217008162	Walker B motif; other site
447217008163	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
447217008164	putative hydrophobic ligand binding site [chemical binding]; other site
447217008165	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
447217008166	active site
447217008167	catalytic residues [active]
447217008168	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
447217008169	DNA binding site [nucleotide binding]
447217008170	Int/Topo IB signature motif; other site
447217008171	active site
447217008172	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217008173	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
447217008174	NeuB family; Region: NeuB; cl00496
447217008175	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
447217008176	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
447217008177	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217008178	ATP binding site [chemical binding]; other site
447217008179	Mg++ binding site [ion binding]; other site
447217008180	motif III; other site
447217008181	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217008182	nucleotide binding region [chemical binding]; other site
447217008183	ATP-binding site [chemical binding]; other site
447217008184	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008185	dimer interface [polypeptide binding]; other site
447217008186	phosphorylation site [posttranslational modification]
447217008187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008188	ATP binding site [chemical binding]; other site
447217008189	Mg2+ binding site [ion binding]; other site
447217008190	G-X-G motif; other site
447217008191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008192	active site
447217008193	phosphorylation site [posttranslational modification]
447217008194	intermolecular recognition site; other site
447217008195	dimerization interface [polypeptide binding]; other site
447217008196	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
447217008197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217008198	putative substrate translocation pore; other site
447217008199	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
447217008200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008201	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
447217008202	L-serine binding site [chemical binding]; other site
447217008203	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
447217008204	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008205	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217008206	Nudix hydrolase homolog; Region: PLN02791
447217008207	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
447217008208	Cytochrome c; Region: Cytochrom_C; cl11414
447217008209	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217008210	urea carboxylase; Region: urea_carbox; TIGR02712
447217008211	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
447217008212	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217008213	carboxyltransferase (CT) interaction site; other site
447217008214	biotinylation site [posttranslational modification]; other site
447217008215	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
447217008216	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
447217008217	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217008218	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217008219	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217008220	FtsX-like permease family; Region: FtsX; cl15850
447217008221	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217008222	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217008223	Walker A/P-loop; other site
447217008224	ATP binding site [chemical binding]; other site
447217008225	Q-loop/lid; other site
447217008226	ABC transporter signature motif; other site
447217008227	Walker B; other site
447217008228	D-loop; other site
447217008229	H-loop/switch region; other site
447217008230	macrolide transporter subunit MacA; Provisional; Region: PRK11578
447217008231	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217008232	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217008233	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
447217008234	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
447217008235	Histidine kinase; Region: His_kinase; pfam06580
447217008236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217008237	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
447217008238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008239	active site
447217008240	phosphorylation site [posttranslational modification]
447217008241	intermolecular recognition site; other site
447217008242	dimerization interface [polypeptide binding]; other site
447217008243	LytTr DNA-binding domain; Region: LytTR; cl04498
447217008244	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217008245	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008246	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
447217008247	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217008248	L-lactate permease; Region: Lactate_perm; cl00701
447217008249	Cysteine-rich domain; Region: CCG; pfam02754
447217008250	Cysteine-rich domain; Region: CCG; pfam02754
447217008251	iron-sulfur cluster-binding protein; Region: TIGR00273
447217008252	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
447217008253	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
447217008254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008256	S-adenosylmethionine binding site [chemical binding]; other site
447217008257	TPR repeat; Region: TPR_11; pfam13414
447217008258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008259	binding surface
447217008260	TPR motif; other site
447217008261	Protein of unknown function, DUF399; Region: DUF399; cl01139
447217008262	multiple promoter invertase; Provisional; Region: mpi; PRK13413
447217008263	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
447217008264	catalytic residues [active]
447217008265	catalytic nucleophile [active]
447217008266	Presynaptic Site I dimer interface [polypeptide binding]; other site
447217008267	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
447217008268	Synaptic Flat tetramer interface [polypeptide binding]; other site
447217008269	Synaptic Site I dimer interface [polypeptide binding]; other site
447217008270	DNA binding site [nucleotide binding]
447217008271	Helix-turn-helix domains; Region: HTH; cl00088
447217008272	DNA-binding interface [nucleotide binding]; DNA binding site
447217008273	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217008274	PilZ domain; Region: PilZ; cl01260
447217008275	Predicted methyltransferase [General function prediction only]; Region: COG3897
447217008276	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
447217008277	Uncharacterized conserved protein [Function unknown]; Region: COG3268
447217008278	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008279	NAD(P) binding site [chemical binding]; other site
447217008280	active site
447217008281	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
447217008282	UPF0126 domain; Region: UPF0126; pfam03458
447217008283	UPF0126 domain; Region: UPF0126; pfam03458
447217008284	GtrA-like protein; Region: GtrA; cl00971
447217008285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
447217008286	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
447217008287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008288	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
447217008289	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
447217008290	homodimer interface [polypeptide binding]; other site
447217008291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008292	catalytic residue [active]
447217008293	Response regulator receiver domain; Region: Response_reg; pfam00072
447217008294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008295	active site
447217008296	phosphorylation site [posttranslational modification]
447217008297	intermolecular recognition site; other site
447217008298	dimerization interface [polypeptide binding]; other site
447217008299	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
447217008300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217008301	non-specific DNA binding site [nucleotide binding]; other site
447217008302	salt bridge; other site
447217008303	sequence-specific DNA binding site [nucleotide binding]; other site
447217008304	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
447217008305	Domain of unknown function (DUF955); Region: DUF955; cl01076
447217008306	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
447217008307	malate synthase A; Region: malate_syn_A; TIGR01344
447217008308	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
447217008309	active site
447217008310	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
447217008311	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
447217008312	tetramer interface [polypeptide binding]; other site
447217008313	active site
447217008314	Mg2+/Mn2+ binding site [ion binding]; other site
447217008315	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217008316	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
447217008317	trehalose synthase; Region: treS_nterm; TIGR02456
447217008318	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
447217008319	active site
447217008320	catalytic site [active]
447217008321	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
447217008322	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
447217008323	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
447217008324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008325	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
447217008326	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
447217008327	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
447217008328	AMP-binding domain protein; Validated; Region: PRK08315
447217008329	AMP-binding enzyme; Region: AMP-binding; cl15778
447217008330	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217008331	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008332	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
447217008333	NADP binding site [chemical binding]; other site
447217008334	dimer interface [polypeptide binding]; other site
447217008335	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
447217008336	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
447217008337	TPP-binding site [chemical binding]; other site
447217008338	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
447217008339	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
447217008340	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
447217008341	dimer interface [polypeptide binding]; other site
447217008342	PYR/PP interface [polypeptide binding]; other site
447217008343	TPP binding site [chemical binding]; other site
447217008344	substrate binding site [chemical binding]; other site
447217008345	pyruvate carboxylase; Reviewed; Region: PRK12999
447217008346	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217008347	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217008348	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
447217008349	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
447217008350	active site
447217008351	catalytic residues [active]
447217008352	metal binding site [ion binding]; metal-binding site
447217008353	homodimer binding site [polypeptide binding]; other site
447217008354	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217008355	carboxyltransferase (CT) interaction site; other site
447217008356	biotinylation site [posttranslational modification]; other site
447217008357	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217008358	octamerization interface [polypeptide binding]; other site
447217008359	diferric-oxygen binding site [ion binding]; other site
447217008360	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217008361	octamerization interface [polypeptide binding]; other site
447217008362	diferric-oxygen binding site [ion binding]; other site
447217008363	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
447217008364	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
447217008365	FAD binding domain; Region: FAD_binding_4; pfam01565
447217008366	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
447217008367	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
447217008368	Cysteine-rich domain; Region: CCG; pfam02754
447217008369	glutamate dehydrogenase; Provisional; Region: PRK09414
447217008370	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
447217008371	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
447217008372	NAD(P) binding site [chemical binding]; other site
447217008373	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217008374	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217008375	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217008376	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217008377	active site
447217008378	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
447217008379	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
447217008380	NAD(P) binding site [chemical binding]; other site
447217008381	catalytic residues [active]
447217008382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008383	NAD(P) binding site [chemical binding]; other site
447217008384	active site
447217008385	photolyase PhrII; Region: phr2; TIGR00591
447217008386	DNA photolyase; Region: DNA_photolyase; pfam00875
447217008387	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
447217008388	Protein of unknown function (DUF523); Region: DUF523; cl00733
447217008389	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
447217008390	Predicted membrane protein [Function unknown]; Region: COG3671
447217008391	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
447217008392	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
447217008393	DNA-K related protein; Region: DUF3731; pfam12531
447217008394	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
447217008395	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
447217008396	Protein of unknown function DUF72; Region: DUF72; cl00777
447217008397	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217008398	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008399	active site
447217008400	catalytic tetrad [active]
447217008401	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
447217008402	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
447217008403	active site
447217008404	catalytic residues [active]
447217008405	metal binding site [ion binding]; metal-binding site
447217008406	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008407	active site
447217008408	catalytic tetrad [active]
447217008409	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
447217008410	intracellular protease, PfpI family; Region: PfpI; TIGR01382
447217008411	proposed catalytic triad [active]
447217008412	conserved cys residue [active]
447217008413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008414	S-adenosylmethionine binding site [chemical binding]; other site
447217008415	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
447217008416	helicase 45; Provisional; Region: PTZ00424
447217008417	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
447217008418	ATP binding site [chemical binding]; other site
447217008419	Mg++ binding site [ion binding]; other site
447217008420	motif III; other site
447217008421	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217008422	nucleotide binding region [chemical binding]; other site
447217008423	ATP-binding site [chemical binding]; other site
447217008424	DbpA RNA binding domain; Region: DbpA; pfam03880
447217008425	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217008426	GAF domain; Region: GAF_2; pfam13185
447217008427	GAF domain; Region: GAF; cl15785
447217008428	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
447217008429	putative deacylase active site [active]
447217008430	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
447217008431	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217008432	metal-binding site
447217008433	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
447217008434	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
447217008435	Ligand binding site; other site
447217008436	Putative Catalytic site; other site
447217008437	DXD motif; other site
447217008438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217008439	active site
447217008440	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217008441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008442	S-adenosylmethionine binding site [chemical binding]; other site
447217008443	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
447217008444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
447217008445	Coenzyme A binding pocket [chemical binding]; other site
447217008446	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
447217008447	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
447217008448	inhibitor-cofactor binding pocket; inhibition site
447217008449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008450	catalytic residue [active]
447217008451	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
447217008452	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
447217008453	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217008454	metal-binding site
447217008455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217008456	ZU5 domain; Region: ZU5; cl02517
447217008457	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
447217008458	NHL repeat; Region: NHL; pfam01436
447217008459	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008460	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008461	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008462	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008463	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008464	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008465	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008466	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008467	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008468	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008469	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008470	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008471	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008472	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008473	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008474	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008475	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008476	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008477	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008478	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008479	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008480	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008481	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008482	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217008483	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217008484	Uncharacterized conserved protein [Function unknown]; Region: COG3391
447217008485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008486	binding surface
447217008487	TPR motif; other site
447217008488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217008489	binding surface
447217008490	TPR motif; other site
447217008491	chaperone protein DnaJ; Provisional; Region: PRK14276
447217008492	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
447217008493	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
447217008494	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
447217008495	active site
447217008496	dimer interface [polypeptide binding]; other site
447217008497	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
447217008498	dimer interface [polypeptide binding]; other site
447217008499	active site
447217008500	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
447217008501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008502	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
447217008503	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217008504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008505	homodimer interface [polypeptide binding]; other site
447217008506	catalytic residue [active]
447217008507	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
447217008508	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
447217008509	Ligand Binding Site [chemical binding]; other site
447217008510	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008511	tetrathionate reductase subunit B; Provisional; Region: PRK14993
447217008512	4Fe-4S binding domain; Region: Fer4; cl02805
447217008513	4Fe-4S binding domain; Region: Fer4; cl02805
447217008514	Polysulphide reductase, NrfD; Region: NrfD; cl01295
447217008515	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217008516	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217008517	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
447217008518	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
447217008519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
447217008520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008521	Walker A motif; other site
447217008522	ATP binding site [chemical binding]; other site
447217008523	Walker B motif; other site
447217008524	arginine finger; other site
447217008525	Rubrerythrin [Energy production and conversion]; Region: COG1592
447217008526	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
447217008527	binuclear metal center [ion binding]; other site
447217008528	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
447217008529	iron binding site [ion binding]; other site
447217008530	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217008531	dimerization interface [polypeptide binding]; other site
447217008532	putative DNA binding site [nucleotide binding]; other site
447217008533	putative Zn2+ binding site [ion binding]; other site
447217008534	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217008535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008536	NAD(P) binding site [chemical binding]; other site
447217008537	active site
447217008538	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217008539	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008540	active site
447217008541	catalytic tetrad [active]
447217008542	Deoxyhypusine synthase; Region: DS; cl00826
447217008543	Peptidase family M1; Region: Peptidase_M1; pfam01433
447217008544	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
447217008545	Zn binding site [ion binding]; other site
447217008546	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008547	Helix-turn-helix domains; Region: HTH; cl00088
447217008548	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217008549	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217008550	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
447217008551	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
447217008552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217008553	FeS/SAM binding site; other site
447217008554	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
447217008555	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
447217008556	nitrogenase iron protein; Region: nifH; TIGR01287
447217008557	Nucleotide-binding sites [chemical binding]; other site
447217008558	Walker A motif; other site
447217008559	Switch I region of nucleotide binding site; other site
447217008560	Fe4S4 binding sites [ion binding]; other site
447217008561	Switch II region of nucleotide binding site; other site
447217008562	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
447217008563	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
447217008564	MoFe protein alpha/beta subunit interactions; other site
447217008565	Alpha subunit P cluster binding residues; other site
447217008566	FeMoco binding residues [chemical binding]; other site
447217008567	MoFe protein alpha subunit/Fe protein contacts; other site
447217008568	MoFe protein dimer/ dimer interactions; other site
447217008569	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
447217008570	MoFe protein beta/alpha subunit interactions; other site
447217008571	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
447217008572	Beta subunit P cluster binding residues; other site
447217008573	MoFe protein beta subunit/Fe protein contacts; other site
447217008574	MoFe protein dimer/ dimer interactions; other site
447217008575	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
447217008576	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
447217008577	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
447217008578	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
447217008579	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
447217008580	4Fe-4S binding domain; Region: Fer4; cl02805
447217008581	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
447217008582	Nif-specific regulatory protein; Region: nifA; TIGR01817
447217008583	GAF domain; Region: GAF; cl15785
447217008584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008585	Walker A motif; other site
447217008586	ATP binding site [chemical binding]; other site
447217008587	Walker B motif; other site
447217008588	arginine finger; other site
447217008589	Helix-turn-helix domains; Region: HTH; cl00088
447217008590	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
447217008591	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217008592	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
447217008593	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217008594	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
447217008595	xanthine dehydrogenase E subunit; Region: pucE; TIGR03198
447217008596	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
447217008597	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
447217008598	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
447217008599	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
447217008600	XdhC Rossmann domain; Region: XdhC_C; pfam13478
447217008601	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217008602	active site
447217008603	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217008604	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
447217008605	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
447217008606	active site
447217008607	Zn binding site [ion binding]; other site
447217008608	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
447217008609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008610	dimer interface [polypeptide binding]; other site
447217008611	phosphorylation site [posttranslational modification]
447217008612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008613	ATP binding site [chemical binding]; other site
447217008614	Mg2+ binding site [ion binding]; other site
447217008615	G-X-G motif; other site
447217008616	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217008617	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217008618	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217008619	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
447217008620	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
447217008621	Walker A/P-loop; other site
447217008622	ATP binding site [chemical binding]; other site
447217008623	Q-loop/lid; other site
447217008624	ABC transporter signature motif; other site
447217008625	Walker B; other site
447217008626	D-loop; other site
447217008627	H-loop/switch region; other site
447217008628	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
447217008629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008630	Walker A/P-loop; other site
447217008631	ATP binding site [chemical binding]; other site
447217008632	Q-loop/lid; other site
447217008633	ABC transporter signature motif; other site
447217008634	Walker B; other site
447217008635	D-loop; other site
447217008636	H-loop/switch region; other site
447217008637	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
447217008638	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217008639	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
447217008640	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217008641	Acetokinase family; Region: Acetate_kinase; cl01029
447217008642	propionate/acetate kinase; Provisional; Region: PRK12379
447217008643	putative phosphoketolase; Provisional; Region: PRK05261
447217008644	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
447217008645	TPP-binding site; other site
447217008646	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
447217008647	XFP C-terminal domain; Region: XFP_C; pfam09363
447217008648	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217008649	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
447217008650	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
447217008651	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217008652	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
447217008653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008654	Walker A/P-loop; other site
447217008655	ATP binding site [chemical binding]; other site
447217008656	Q-loop/lid; other site
447217008657	ABC transporter signature motif; other site
447217008658	Walker B; other site
447217008659	D-loop; other site
447217008660	H-loop/switch region; other site
447217008661	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
447217008662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217008663	dimer interface [polypeptide binding]; other site
447217008664	conserved gate region; other site
447217008665	putative PBP binding loops; other site
447217008666	ABC-ATPase subunit interface; other site
447217008667	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
447217008668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217008669	dimer interface [polypeptide binding]; other site
447217008670	conserved gate region; other site
447217008671	putative PBP binding loops; other site
447217008672	ABC-ATPase subunit interface; other site
447217008673	RNA polymerase factor sigma-70; Validated; Region: PRK08241
447217008674	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217008675	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217008676	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217008677	DoxX; Region: DoxX; cl00976
447217008678	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
447217008679	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
447217008680	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217008681	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217008682	DNA binding residues [nucleotide binding]
447217008683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008685	GTPase RsgA; Reviewed; Region: PRK01889
447217008686	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
447217008687	GTPase/Zn-binding domain interface [polypeptide binding]; other site
447217008688	GTP/Mg2+ binding site [chemical binding]; other site
447217008689	G4 box; other site
447217008690	G5 box; other site
447217008691	G1 box; other site
447217008692	Switch I region; other site
447217008693	G2 box; other site
447217008694	G3 box; other site
447217008695	Switch II region; other site
447217008696	PilZ domain; Region: PilZ; cl01260
447217008697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008698	active site
447217008699	phosphorylation site [posttranslational modification]
447217008700	intermolecular recognition site; other site
447217008701	dimerization interface [polypeptide binding]; other site
447217008702	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
447217008703	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
447217008704	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
447217008705	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
447217008706	active site
447217008707	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
447217008708	Helix-turn-helix domains; Region: HTH; cl00088
447217008709	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217008710	classical (c) SDRs; Region: SDR_c; cd05233
447217008711	NAD(P) binding site [chemical binding]; other site
447217008712	active site
447217008713	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
447217008714	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217008715	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
447217008716	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
447217008717	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217008718	NMT1-like family; Region: NMT1_2; cl15260
447217008719	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
447217008720	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
447217008721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217008722	phosphorylation site [posttranslational modification]
447217008723	dimer interface [polypeptide binding]; other site
447217008724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217008725	ATP binding site [chemical binding]; other site
447217008726	Mg2+ binding site [ion binding]; other site
447217008727	G-X-G motif; other site
447217008728	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217008729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217008730	active site
447217008731	phosphorylation site [posttranslational modification]
447217008732	intermolecular recognition site; other site
447217008733	dimerization interface [polypeptide binding]; other site
447217008734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217008735	Walker A motif; other site
447217008736	ATP binding site [chemical binding]; other site
447217008737	Walker B motif; other site
447217008738	arginine finger; other site
447217008739	Helix-turn-helix domains; Region: HTH; cl00088
447217008740	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
447217008741	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217008742	homodimer interface [polypeptide binding]; other site
447217008743	substrate-cofactor binding pocket; other site
447217008744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217008745	catalytic residue [active]
447217008746	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
447217008747	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217008748	Walker A/P-loop; other site
447217008749	ATP binding site [chemical binding]; other site
447217008750	Q-loop/lid; other site
447217008751	ABC transporter signature motif; other site
447217008752	Walker B; other site
447217008753	D-loop; other site
447217008754	H-loop/switch region; other site
447217008755	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217008756	FtsX-like permease family; Region: FtsX; cl15850
447217008757	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217008758	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
447217008759	Helix-turn-helix domains; Region: HTH; cl00088
447217008760	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217008761	active site
447217008762	CHRD domain; Region: CHRD; cl06473
447217008763	CHRD domain; Region: CHRD; cl06473
447217008764	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
447217008765	iron-sulfur cluster [ion binding]; other site
447217008766	[2Fe-2S] cluster binding site [ion binding]; other site
447217008767	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
447217008768	iron-sulfur cluster [ion binding]; other site
447217008769	[2Fe-2S] cluster binding site [ion binding]; other site
447217008770	YceI-like domain; Region: YceI; cl01001
447217008771	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217008772	Helix-turn-helix domains; Region: HTH; cl00088
447217008773	Cytochrome c; Region: Cytochrom_C; cl11414
447217008774	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
447217008775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008776	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
447217008777	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
447217008778	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
447217008779	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
447217008780	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
447217008781	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
447217008782	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217008783	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217008784	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217008785	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217008786	ligand binding site [chemical binding]; other site
447217008787	flexible hinge region; other site
447217008788	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217008789	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217008790	metal binding triad; other site
447217008791	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
447217008792	Ubiquitin-like proteins; Region: UBQ; cl00155
447217008793	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
447217008794	Protein of unknown function DUF82; Region: DUF82; pfam01927
447217008795	Cache domain; Region: Cache_2; cl07034
447217008796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
447217008797	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217008798	dimer interface [polypeptide binding]; other site
447217008799	putative CheW interface [polypeptide binding]; other site
447217008800	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217008801	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217008802	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217008803	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
447217008804	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217008805	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217008806	putative NAD(P) binding site [chemical binding]; other site
447217008807	putative substrate binding site [chemical binding]; other site
447217008808	catalytic Zn binding site [ion binding]; other site
447217008809	structural Zn binding site [ion binding]; other site
447217008810	dimer interface [polypeptide binding]; other site
447217008811	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217008812	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217008813	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
447217008814	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008815	Walker A/P-loop; other site
447217008816	ATP binding site [chemical binding]; other site
447217008817	Q-loop/lid; other site
447217008818	ABC transporter signature motif; other site
447217008819	Walker B; other site
447217008820	D-loop; other site
447217008821	H-loop/switch region; other site
447217008822	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
447217008823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217008824	Helix-turn-helix domains; Region: HTH; cl00088
447217008825	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
447217008826	putative effector binding pocket; other site
447217008827	putative dimerization interface [polypeptide binding]; other site
447217008828	UPF0126 domain; Region: UPF0126; pfam03458
447217008829	Predicted membrane protein [Function unknown]; Region: COG2860
447217008830	UPF0126 domain; Region: UPF0126; pfam03458
447217008831	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
447217008832	DNA-binding site [nucleotide binding]; DNA binding site
447217008833	RNA-binding motif; other site
447217008834	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
447217008835	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217008836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217008837	S-adenosylmethionine binding site [chemical binding]; other site
447217008838	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
447217008839	Putative glucoamylase; Region: Glycoamylase; pfam10091
447217008840	Putative carbohydrate binding domain; Region: CBM_X; cl05621
447217008841	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
447217008842	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
447217008843	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
447217008844	Putative carbohydrate binding domain; Region: CBM_X; cl05621
447217008845	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
447217008846	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
447217008847	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
447217008848	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008849	Walker A/P-loop; other site
447217008850	ATP binding site [chemical binding]; other site
447217008851	Q-loop/lid; other site
447217008852	ABC transporter signature motif; other site
447217008853	Walker B; other site
447217008854	D-loop; other site
447217008855	H-loop/switch region; other site
447217008856	NMT1-like family; Region: NMT1_2; cl15260
447217008857	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
447217008858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
447217008859	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217008860	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217008861	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
447217008862	PA/protease or protease-like domain interface [polypeptide binding]; other site
447217008863	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
447217008864	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
447217008865	YceI-like domain; Region: YceI; cl01001
447217008866	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
447217008867	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
447217008868	Uncharacterized conserved protein [Function unknown]; Region: COG2461
447217008869	Family of unknown function (DUF438); Region: DUF438; pfam04282
447217008870	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217008871	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
447217008872	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
447217008873	Prostaglandin dehydrogenases; Region: PGDH; cd05288
447217008874	NAD(P) binding site [chemical binding]; other site
447217008875	substrate binding site [chemical binding]; other site
447217008876	dimer interface [polypeptide binding]; other site
447217008877	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
447217008878	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217008879	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
447217008880	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
447217008881	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217008882	active site
447217008883	metal binding site [ion binding]; metal-binding site
447217008884	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
447217008885	FOG: CBS domain [General function prediction only]; Region: COG0517
447217008886	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217008887	FOG: CBS domain [General function prediction only]; Region: COG0517
447217008888	FOG: CBS domain [General function prediction only]; Region: COG0517
447217008889	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
447217008890	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
447217008891	dimer interface [polypeptide binding]; other site
447217008892	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217008893	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
447217008894	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008895	NAD(P) binding site [chemical binding]; other site
447217008896	active site
447217008897	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
447217008898	Phosphoesterase family; Region: Phosphoesterase; cl15450
447217008899	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
447217008900	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
447217008901	Helix-turn-helix domains; Region: HTH; cl00088
447217008902	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
447217008903	substrate binding pocket [chemical binding]; other site
447217008904	dimerization interface [polypeptide binding]; other site
447217008905	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217008906	Integrase core domain; Region: rve; cl01316
447217008907	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217008908	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217008909	AAA domain; Region: AAA_21; pfam13304
447217008910	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
447217008911	active site
447217008912	metal binding site [ion binding]; metal-binding site
447217008913	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
447217008914	Family description; Region: UvrD_C_2; cl15862
447217008915	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217008916	non-specific DNA binding site [nucleotide binding]; other site
447217008917	salt bridge; other site
447217008918	sequence-specific DNA binding site [nucleotide binding]; other site
447217008919	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008920	Dynamin family; Region: Dynamin_N; pfam00350
447217008921	G1 box; other site
447217008922	GTP/Mg2+ binding site [chemical binding]; other site
447217008923	G2 box; other site
447217008924	Switch I region; other site
447217008925	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217008926	non-specific DNA binding site [nucleotide binding]; other site
447217008927	salt bridge; other site
447217008928	sequence-specific DNA binding site [nucleotide binding]; other site
447217008929	Predicted transcriptional regulator [Transcription]; Region: COG5340
447217008930	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
447217008931	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
447217008932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
447217008933	Helix-turn-helix domains; Region: HTH; cl00088
447217008934	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
447217008935	putative effector binding pocket; other site
447217008936	putative dimerization interface [polypeptide binding]; other site
447217008937	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
447217008938	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
447217008939	putative NAD(P) binding site [chemical binding]; other site
447217008940	putative substrate binding site [chemical binding]; other site
447217008941	catalytic Zn binding site [ion binding]; other site
447217008942	structural Zn binding site [ion binding]; other site
447217008943	dimer interface [polypeptide binding]; other site
447217008944	Cupin domain; Region: Cupin_2; cl09118
447217008945	Cyclophilin-like; Region: Cyclophil_like; cl00950
447217008946	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
447217008947	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217008948	catalytic Zn binding site [ion binding]; other site
447217008949	NAD(P) binding site [chemical binding]; other site
447217008950	structural Zn binding site [ion binding]; other site
447217008951	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217008952	active site
447217008953	catalytic tetrad [active]
447217008954	transcriptional regulator; Provisional; Region: PRK10632
447217008955	Helix-turn-helix domains; Region: HTH; cl00088
447217008956	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
447217008957	putative effector binding pocket; other site
447217008958	putative dimerization interface [polypeptide binding]; other site
447217008959	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
447217008960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217008961	NAD(P) binding site [chemical binding]; other site
447217008962	active site
447217008963	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
447217008964	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
447217008965	putative NAD(P) binding site [chemical binding]; other site
447217008966	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
447217008967	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
447217008968	catalytic Zn binding site [ion binding]; other site
447217008969	NAD(P) binding site [chemical binding]; other site
447217008970	structural Zn binding site [ion binding]; other site
447217008971	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217008972	dimerization interface [polypeptide binding]; other site
447217008973	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
447217008974	proline aminopeptidase P II; Provisional; Region: PRK10879
447217008975	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
447217008976	active site
447217008977	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
447217008978	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217008979	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
447217008980	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
447217008981	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
447217008982	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217008983	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
447217008984	FeoA domain; Region: FeoA; cl00838
447217008985	FeoA domain; Region: FeoA; cl00838
447217008986	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
447217008987	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
447217008988	G1 box; other site
447217008989	GTP/Mg2+ binding site [chemical binding]; other site
447217008990	Switch I region; other site
447217008991	G2 box; other site
447217008992	G3 box; other site
447217008993	Switch II region; other site
447217008994	G4 box; other site
447217008995	G5 box; other site
447217008996	Nucleoside recognition; Region: Gate; cl00486
447217008997	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
447217008998	Nucleoside recognition; Region: Gate; cl00486
447217008999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009000	NAD(P) binding site [chemical binding]; other site
447217009001	Cadherin repeat-like domain; Region: CA_like; cl15786
447217009002	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
447217009003	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
447217009004	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
447217009005	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217009006	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217009007	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217009008	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217009009	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
447217009010	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217009011	dimer interface [polypeptide binding]; other site
447217009012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009013	catalytic residue [active]
447217009014	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
447217009015	Sel1 repeat; Region: Sel1; cl02723
447217009016	Sel1 repeat; Region: Sel1; cl02723
447217009017	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217009018	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
447217009019	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217009020	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
447217009021	LemA family; Region: LemA; cl00742
447217009022	Peptidase family M48; Region: Peptidase_M48; cl12018
447217009023	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
447217009024	signal recognition particle protein; Provisional; Region: PRK10867
447217009025	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
447217009026	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
447217009027	P loop; other site
447217009028	GTP binding site [chemical binding]; other site
447217009029	Signal peptide binding domain; Region: SRP_SPB; pfam02978
447217009030	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
447217009031	putative ligand binding pocket/active site [active]
447217009032	putative metal binding site [ion binding]; other site
447217009033	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217009034	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
447217009035	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
447217009036	TMP-binding site; other site
447217009037	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
447217009038	putative active site; other site
447217009039	putative metal binding residues [ion binding]; other site
447217009040	signature motif; other site
447217009041	putative triphosphate binding site [ion binding]; other site
447217009042	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217009043	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217009044	active site
447217009045	metal binding site [ion binding]; metal-binding site
447217009046	CotH protein; Region: CotH; pfam08757
447217009047	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217009048	phosphopeptide binding site; other site
447217009049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009050	binding surface
447217009051	TPR motif; other site
447217009052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009053	TPR motif; other site
447217009054	binding surface
447217009055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009056	binding surface
447217009057	TPR motif; other site
447217009058	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217009059	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
447217009060	PilZ domain; Region: PilZ; cl01260
447217009061	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217009062	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217009063	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
447217009064	putative active site [active]
447217009065	putative substrate binding site [chemical binding]; other site
447217009066	ATP binding site [chemical binding]; other site
447217009067	TPR repeat; Region: TPR_11; pfam13414
447217009068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009069	binding surface
447217009070	TPR motif; other site
447217009071	TPR repeat; Region: TPR_11; pfam13414
447217009072	TPR repeat; Region: TPR_11; pfam13414
447217009073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009074	binding surface
447217009075	TPR motif; other site
447217009076	TPR repeat; Region: TPR_11; pfam13414
447217009077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009078	binding surface
447217009079	TPR motif; other site
447217009080	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
447217009081	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217009082	phosphopeptide binding site; other site
447217009083	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
447217009084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009085	Walker A motif; other site
447217009086	ATP binding site [chemical binding]; other site
447217009087	Walker B motif; other site
447217009088	arginine finger; other site
447217009089	Helix-turn-helix domains; Region: HTH; cl00088
447217009090	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217009091	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
447217009092	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217009093	ligand binding site [chemical binding]; other site
447217009094	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217009095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009096	active site
447217009097	phosphorylation site [posttranslational modification]
447217009098	intermolecular recognition site; other site
447217009099	dimerization interface [polypeptide binding]; other site
447217009100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009101	Walker A motif; other site
447217009102	ATP binding site [chemical binding]; other site
447217009103	Walker B motif; other site
447217009104	arginine finger; other site
447217009105	Helix-turn-helix domains; Region: HTH; cl00088
447217009106	Transglycosylase; Region: Transgly; cl07896
447217009107	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217009108	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217009109	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
447217009110	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
447217009111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009112	dimer interface [polypeptide binding]; other site
447217009113	phosphorylation site [posttranslational modification]
447217009114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009115	ATP binding site [chemical binding]; other site
447217009116	Mg2+ binding site [ion binding]; other site
447217009117	G-X-G motif; other site
447217009118	Peptidase S46; Region: Peptidase_S46; pfam10459
447217009119	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
447217009120	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
447217009121	Quinolinate synthetase A protein; Region: NadA; cl00420
447217009122	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217009123	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
447217009124	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217009125	Found in ATP-dependent protease La (LON); Region: LON; smart00464
447217009126	Mediator complex protein; Region: Med11; pfam10280
447217009127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009128	Walker A motif; other site
447217009129	ATP binding site [chemical binding]; other site
447217009130	Walker B motif; other site
447217009131	arginine finger; other site
447217009132	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
447217009133	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217009134	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217009135	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217009136	catalytic residue [active]
447217009137	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
447217009138	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
447217009139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009140	Walker A motif; other site
447217009141	ATP binding site [chemical binding]; other site
447217009142	Walker B motif; other site
447217009143	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
447217009144	Clp protease; Region: CLP_protease; pfam00574
447217009145	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
447217009146	oligomer interface [polypeptide binding]; other site
447217009147	active site residues [active]
447217009148	trigger factor; Region: tig; TIGR00115
447217009149	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
447217009150	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
447217009151	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
447217009152	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
447217009153	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
447217009154	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
447217009155	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
447217009156	Ligand binding site; other site
447217009157	Putative Catalytic site; other site
447217009158	DXD motif; other site
447217009159	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
447217009160	active site
447217009161	dimerization interface [polypeptide binding]; other site
447217009162	ribonuclease PH; Reviewed; Region: rph; PRK00173
447217009163	Ribonuclease PH; Region: RNase_PH_bact; cd11362
447217009164	hexamer interface [polypeptide binding]; other site
447217009165	active site
447217009166	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
447217009167	active site
447217009168	metal binding site [ion binding]; metal-binding site
447217009169	selenium donor protein; Region: selD; TIGR00476
447217009170	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
447217009171	dimerization interface [polypeptide binding]; other site
447217009172	putative ATP binding site [chemical binding]; other site
447217009173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009174	binding surface
447217009175	TPR motif; other site
447217009176	TPR repeat; Region: TPR_11; pfam13414
447217009177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217009178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009179	binding surface
447217009180	TPR motif; other site
447217009181	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
447217009182	RecX family; Region: RecX; cl00936
447217009183	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
447217009184	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009185	ATP binding site [chemical binding]; other site
447217009186	Walker B motif; other site
447217009187	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
447217009188	PLD-like domain; Region: PLDc_2; pfam13091
447217009189	putative active site [active]
447217009190	catalytic site [active]
447217009191	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
447217009192	PLD-like domain; Region: PLDc_2; pfam13091
447217009193	putative active site [active]
447217009194	catalytic site [active]
447217009195	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
447217009196	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
447217009197	23S rRNA interface [nucleotide binding]; other site
447217009198	L3 interface [polypeptide binding]; other site
447217009199	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
447217009200	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009201	Family description; Region: UvrD_C_2; cl15862
447217009202	DoxX; Region: DoxX; cl00976
447217009203	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
447217009204	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
447217009205	CGNR zinc finger; Region: zf-CGNR; pfam11706
447217009206	Cupin domain; Region: Cupin_2; cl09118
447217009207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217009208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217009209	putative substrate translocation pore; other site
447217009210	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217009211	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217009212	active site
447217009213	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
447217009214	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
447217009215	putative C-terminal domain interface [polypeptide binding]; other site
447217009216	putative GSH binding site (G-site) [chemical binding]; other site
447217009217	putative dimer interface [polypeptide binding]; other site
447217009218	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
447217009219	N-terminal domain interface [polypeptide binding]; other site
447217009220	dimer interface [polypeptide binding]; other site
447217009221	substrate binding pocket (H-site) [chemical binding]; other site
447217009222	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217009223	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217009224	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217009225	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
447217009226	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
447217009227	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
447217009228	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
447217009229	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217009230	dimerization interface [polypeptide binding]; other site
447217009231	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009232	dimer interface [polypeptide binding]; other site
447217009233	phosphorylation site [posttranslational modification]
447217009234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009235	ATP binding site [chemical binding]; other site
447217009236	Mg2+ binding site [ion binding]; other site
447217009237	G-X-G motif; other site
447217009238	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
447217009239	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009240	Walker A/P-loop; other site
447217009241	ATP binding site [chemical binding]; other site
447217009242	Q-loop/lid; other site
447217009243	ABC transporter signature motif; other site
447217009244	Walker B; other site
447217009245	D-loop; other site
447217009246	H-loop/switch region; other site
447217009247	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009248	Walker A/P-loop; other site
447217009249	ATP binding site [chemical binding]; other site
447217009250	Q-loop/lid; other site
447217009251	ABC transporter signature motif; other site
447217009252	Walker B; other site
447217009253	D-loop; other site
447217009254	H-loop/switch region; other site
447217009255	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217009256	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
447217009257	active site
447217009258	dimerization interface [polypeptide binding]; other site
447217009259	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
447217009260	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
447217009261	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217009262	catalytic residues [active]
447217009263	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
447217009264	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
447217009265	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217009266	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217009267	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217009268	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217009269	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
447217009270	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
447217009271	dimer interface [polypeptide binding]; other site
447217009272	catalytic triad [active]
447217009273	acetyl-CoA synthetase; Provisional; Region: PRK00174
447217009274	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
447217009275	AMP-binding enzyme; Region: AMP-binding; cl15778
447217009276	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217009277	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
447217009278	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
447217009279	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
447217009280	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
447217009281	glutathione S-transferase; Provisional; Region: PRK15113
447217009282	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217009283	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
447217009284	N-terminal domain interface [polypeptide binding]; other site
447217009285	putative dimer interface [polypeptide binding]; other site
447217009286	putative substrate binding pocket (H-site) [chemical binding]; other site
447217009287	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217009288	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217009289	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217009290	dimer interface [polypeptide binding]; other site
447217009291	putative CheW interface [polypeptide binding]; other site
447217009292	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
447217009293	Protein of unknown function, DUF481; Region: DUF481; cl01213
447217009294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217009295	ATP binding site [chemical binding]; other site
447217009296	putative Mg++ binding site [ion binding]; other site
447217009297	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
447217009298	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009299	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
447217009300	PQ loop repeat; Region: PQ-loop; cl12056
447217009301	Protein of unknown function, DUF488; Region: DUF488; cl01246
447217009302	RF-1 domain; Region: RF-1; cl02875
447217009303	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
447217009304	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
447217009305	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217009306	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
447217009307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
447217009308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009309	binding surface
447217009310	TPR motif; other site
447217009311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009312	binding surface
447217009313	TPR motif; other site
447217009314	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217009315	Protein of unknown function, DUF482; Region: DUF482; pfam04339
447217009316	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
447217009317	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
447217009318	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
447217009319	maleylacetoacetate isomerase; Region: maiA; TIGR01262
447217009320	C-terminal domain interface [polypeptide binding]; other site
447217009321	GSH binding site (G-site) [chemical binding]; other site
447217009322	putative dimer interface [polypeptide binding]; other site
447217009323	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
447217009324	dimer interface [polypeptide binding]; other site
447217009325	N-terminal domain interface [polypeptide binding]; other site
447217009326	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
447217009327	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
447217009328	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
447217009329	dimer interface [polypeptide binding]; other site
447217009330	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
447217009331	active site
447217009332	Fe binding site [ion binding]; other site
447217009333	Cupin domain; Region: Cupin_2; cl09118
447217009334	alanine racemase; Reviewed; Region: alr; PRK00053
447217009335	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
447217009336	active site
447217009337	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217009338	dimer interface [polypeptide binding]; other site
447217009339	substrate binding site [chemical binding]; other site
447217009340	catalytic residues [active]
447217009341	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
447217009342	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
447217009343	homodimer interface [polypeptide binding]; other site
447217009344	substrate-cofactor binding pocket; other site
447217009345	catalytic residue [active]
447217009346	Helix-turn-helix domains; Region: HTH; cl00088
447217009347	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
447217009348	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217009349	motif 1; other site
447217009350	dimer interface [polypeptide binding]; other site
447217009351	active site
447217009352	motif 2; other site
447217009353	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
447217009354	motif 3; other site
447217009355	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217009356	Amidase; Region: Amidase; cl11426
447217009357	Amidase; Region: Amidase; cl11426
447217009358	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217009359	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217009360	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
447217009361	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
447217009362	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
447217009363	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
447217009364	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
447217009365	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
447217009366	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
447217009367	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
447217009368	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
447217009369	generic binding surface II; other site
447217009370	generic binding surface I; other site
447217009371	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
447217009372	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
447217009373	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
447217009374	DNA binding residues [nucleotide binding]
447217009375	dimerization interface [polypeptide binding]; other site
447217009376	threonine dehydratase; Provisional; Region: PRK08198
447217009377	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
447217009378	tetramer interface [polypeptide binding]; other site
447217009379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009380	catalytic residue [active]
447217009381	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
447217009382	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217009383	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217009384	active site
447217009385	ATP binding site [chemical binding]; other site
447217009386	substrate binding site [chemical binding]; other site
447217009387	activation loop (A-loop); other site
447217009388	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
447217009389	structural tetrad; other site
447217009390	Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647
447217009391	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
447217009392	structural tetrad; other site
447217009393	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
447217009394	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
447217009395	structural tetrad; other site
447217009396	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
447217009397	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217009398	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217009399	catalytic residue [active]
447217009400	biotin synthase; Region: bioB; TIGR00433
447217009401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217009402	FeS/SAM binding site; other site
447217009403	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
447217009404	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
447217009405	DNA repair protein RadA; Provisional; Region: PRK11823
447217009406	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217009407	Walker A motif; other site
447217009408	ATP binding site [chemical binding]; other site
447217009409	Walker B motif; other site
447217009410	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
447217009411	glycerol kinase; Provisional; Region: glpK; PRK00047
447217009412	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
447217009413	N- and C-terminal domain interface [polypeptide binding]; other site
447217009414	active site
447217009415	MgATP binding site [chemical binding]; other site
447217009416	catalytic site [active]
447217009417	metal binding site [ion binding]; metal-binding site
447217009418	glycerol binding site [chemical binding]; other site
447217009419	homotetramer interface [polypeptide binding]; other site
447217009420	homodimer interface [polypeptide binding]; other site
447217009421	FBP binding site [chemical binding]; other site
447217009422	protein IIAGlc interface [polypeptide binding]; other site
447217009423	Esterase/lipase [General function prediction only]; Region: COG1647
447217009424	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
447217009425	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
447217009426	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
447217009427	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
447217009428	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217009429	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
447217009430	Uncharacterized conserved protein [Function unknown]; Region: COG3391
447217009431	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217009432	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217009433	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
447217009434	dimer interface [polypeptide binding]; other site
447217009435	putative PBP binding regions; other site
447217009436	ABC-ATPase subunit  interface; other site
447217009437	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
447217009438	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
447217009439	Walker A/P-loop; other site
447217009440	ATP binding site [chemical binding]; other site
447217009441	Q-loop/lid; other site
447217009442	ABC transporter signature motif; other site
447217009443	Walker B; other site
447217009444	D-loop; other site
447217009445	H-loop/switch region; other site
447217009446	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217009447	active site
447217009448	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217009449	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217009450	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
447217009451	active site
447217009452	tetramer interface; other site
447217009453	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217009454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009455	active site
447217009456	phosphorylation site [posttranslational modification]
447217009457	intermolecular recognition site; other site
447217009458	dimerization interface [polypeptide binding]; other site
447217009459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009460	Walker A motif; other site
447217009461	ATP binding site [chemical binding]; other site
447217009462	Walker B motif; other site
447217009463	arginine finger; other site
447217009464	Helix-turn-helix domains; Region: HTH; cl00088
447217009465	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009467	active site
447217009468	phosphorylation site [posttranslational modification]
447217009469	intermolecular recognition site; other site
447217009470	dimerization interface [polypeptide binding]; other site
447217009471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009472	dimer interface [polypeptide binding]; other site
447217009473	phosphorylation site [posttranslational modification]
447217009474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009475	ATP binding site [chemical binding]; other site
447217009476	G-X-G motif; other site
447217009477	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009479	active site
447217009480	phosphorylation site [posttranslational modification]
447217009481	intermolecular recognition site; other site
447217009482	dimerization interface [polypeptide binding]; other site
447217009483	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217009484	metal binding site [ion binding]; metal-binding site
447217009485	active site
447217009486	I-site; other site
447217009487	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
447217009488	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
447217009489	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
447217009490	pteridine reductase; Provisional; Region: PRK09135
447217009491	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009492	NAD(P) binding site [chemical binding]; other site
447217009493	active site
447217009494	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
447217009495	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217009496	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
447217009497	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
447217009498	NAD binding site [chemical binding]; other site
447217009499	homotetramer interface [polypeptide binding]; other site
447217009500	homodimer interface [polypeptide binding]; other site
447217009501	substrate binding site [chemical binding]; other site
447217009502	active site
447217009503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009504	TPR motif; other site
447217009505	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217009506	binding surface
447217009507	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
447217009508	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
447217009509	GTP binding site; other site
447217009510	CrcB-like protein; Region: CRCB; cl09114
447217009511	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
447217009512	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217009513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217009514	S-adenosylmethionine binding site [chemical binding]; other site
447217009515	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
447217009516	Pirin-related protein [General function prediction only]; Region: COG1741
447217009517	Cupin domain; Region: Cupin_2; cl09118
447217009518	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
447217009519	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
447217009520	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009521	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009522	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
447217009523	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
447217009524	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
447217009525	MPN+ (JAMM) motif; other site
447217009526	Zinc-binding site [ion binding]; other site
447217009527	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
447217009528	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
447217009529	ATP binding site [chemical binding]; other site
447217009530	substrate interface [chemical binding]; other site
447217009531	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217009532	active site residue [active]
447217009533	Ubiquitin-like proteins; Region: UBQ; cl00155
447217009534	charged pocket; other site
447217009535	hydrophobic patch; other site
447217009536	threonine synthase; Validated; Region: PRK07591
447217009537	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
447217009538	homodimer interface [polypeptide binding]; other site
447217009539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217009540	catalytic residue [active]
447217009541	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
447217009542	putative homotetramer interface [polypeptide binding]; other site
447217009543	putative homodimer interface [polypeptide binding]; other site
447217009544	putative allosteric switch controlling residues; other site
447217009545	putative metal binding site [ion binding]; other site
447217009546	putative homodimer-homodimer interface [polypeptide binding]; other site
447217009547	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
447217009548	metal-binding site [ion binding]
447217009549	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
447217009550	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
447217009551	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217009552	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
447217009553	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217009554	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
447217009555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217009556	YCII-related domain; Region: YCII; cl00999
447217009557	Phosphoesterase family; Region: Phosphoesterase; cl15450
447217009558	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217009559	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217009560	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217009561	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217009562	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
447217009563	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
447217009564	active site
447217009565	catalytic tetrad [active]
447217009566	Helix-turn-helix domains; Region: HTH; cl00088
447217009567	LysR family transcriptional regulator; Provisional; Region: PRK14997
447217009568	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217009569	dimerization interface [polypeptide binding]; other site
447217009570	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217009571	catalytic residues [active]
447217009572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
447217009573	putative lipid kinase; Reviewed; Region: PRK13057
447217009574	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
447217009575	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217009576	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217009577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217009578	dimer interface [polypeptide binding]; other site
447217009579	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
447217009580	putative CheW interface [polypeptide binding]; other site
447217009581	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
447217009582	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217009583	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217009584	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
447217009585	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
447217009586	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217009587	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
447217009588	IMP binding site; other site
447217009589	dimer interface [polypeptide binding]; other site
447217009590	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
447217009591	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217009592	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217009593	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217009594	Walker A/P-loop; other site
447217009595	ATP binding site [chemical binding]; other site
447217009596	Q-loop/lid; other site
447217009597	ABC transporter signature motif; other site
447217009598	Walker B; other site
447217009599	D-loop; other site
447217009600	H-loop/switch region; other site
447217009601	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217009602	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217009603	FtsX-like permease family; Region: FtsX; cl15850
447217009604	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
447217009605	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
447217009606	active site residue [active]
447217009607	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
447217009608	active site residue [active]
447217009609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009610	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009611	active site
447217009612	phosphorylation site [posttranslational modification]
447217009613	intermolecular recognition site; other site
447217009614	dimerization interface [polypeptide binding]; other site
447217009615	HEAT repeats; Region: HEAT_2; pfam13646
447217009616	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
447217009617	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
447217009618	DXD motif; other site
447217009619	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
447217009620	HflK protein; Region: hflK; TIGR01933
447217009621	HflC protein; Region: hflC; TIGR01932
447217009622	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
447217009623	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
447217009624	hypothetical protein; Validated; Region: PRK07121
447217009625	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
447217009626	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
447217009627	catalytic triad [active]
447217009628	GAF domain; Region: GAF; cl15785
447217009629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217009630	dimer interface [polypeptide binding]; other site
447217009631	phosphorylation site [posttranslational modification]
447217009632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217009633	ATP binding site [chemical binding]; other site
447217009634	Mg2+ binding site [ion binding]; other site
447217009635	G-X-G motif; other site
447217009636	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
447217009637	Peptidase family M48; Region: Peptidase_M48; cl12018
447217009638	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217009639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217009640	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
447217009641	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
447217009642	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
447217009643	putative active site [active]
447217009644	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217009645	TPR repeat; Region: TPR_11; pfam13414
447217009646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009647	binding surface
447217009648	TPR motif; other site
447217009649	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
447217009650	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
447217009651	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217009652	catalytic residue [active]
447217009653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009654	L-aspartate oxidase; Provisional; Region: PRK09077
447217009655	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
447217009656	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217009657	active site
447217009658	ParB-like nuclease domain; Region: ParBc; cl02129
447217009659	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217009660	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217009661	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
447217009662	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217009663	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
447217009664	DNA binding residues [nucleotide binding]
447217009665	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
447217009666	Predicted amidohydrolase [General function prediction only]; Region: COG0388
447217009667	putative active site [active]
447217009668	catalytic triad [active]
447217009669	dimer interface [polypeptide binding]; other site
447217009670	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
447217009671	Interdomain contacts; other site
447217009672	Cytokine receptor motif; other site
447217009673	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009674	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
447217009675	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
447217009676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009677	TIGR01777 family protein; Region: yfcH
447217009678	NAD(P) binding site [chemical binding]; other site
447217009679	active site
447217009680	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
447217009681	active site
447217009682	putative substrate binding region [chemical binding]; other site
447217009683	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
447217009684	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217009685	active site
447217009686	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217009687	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217009688	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
447217009689	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
447217009690	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
447217009691	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
447217009692	putative substrate binding region [chemical binding]; other site
447217009693	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
447217009694	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
447217009695	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
447217009696	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
447217009697	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
447217009698	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
447217009699	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
447217009700	catalytic residue [active]
447217009701	putative FPP diphosphate  binding site; other site
447217009702	putative FPP binding hydrophobic cleft; other site
447217009703	dimer interface [polypeptide binding]; other site
447217009704	putative IPP diphosphate binding site; other site
447217009705	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217009706	active site
447217009707	ATP binding site [chemical binding]; other site
447217009708	Phosphotransferase enzyme family; Region: APH; pfam01636
447217009709	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
447217009710	substrate binding site [chemical binding]; other site
447217009711	activation loop (A-loop); other site
447217009712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009713	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217009714	Walker A motif; other site
447217009715	ATP binding site [chemical binding]; other site
447217009716	Walker B motif; other site
447217009717	aspartate kinase; Reviewed; Region: PRK06635
447217009718	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
447217009719	putative nucleotide binding site [chemical binding]; other site
447217009720	putative catalytic residues [active]
447217009721	putative Mg ion binding site [ion binding]; other site
447217009722	putative aspartate binding site [chemical binding]; other site
447217009723	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
447217009724	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
447217009725	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
447217009726	oligomerisation interface [polypeptide binding]; other site
447217009727	mobile loop; other site
447217009728	roof hairpin; other site
447217009729	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
447217009730	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
447217009731	ring oligomerisation interface [polypeptide binding]; other site
447217009732	ATP/Mg binding site [chemical binding]; other site
447217009733	stacking interactions; other site
447217009734	hinge regions; other site
447217009735	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217009736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009737	binding surface
447217009738	TPR motif; other site
447217009739	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217009740	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
447217009741	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
447217009742	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
447217009743	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
447217009744	Spore Coat Protein U domain; Region: SCPU; cl02253
447217009745	Spore Coat Protein U domain; Region: SCPU; cl02253
447217009746	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
447217009747	active site
447217009748	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
447217009749	amphipathic channel; other site
447217009750	Asn-Pro-Ala signature motifs; other site
447217009751	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
447217009752	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
447217009753	RDD family; Region: RDD; cl00746
447217009754	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
447217009755	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
447217009756	DNA binding site [nucleotide binding]
447217009757	Int/Topo IB signature motif; other site
447217009758	active site
447217009759	catalytic residues [active]
447217009760	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
447217009761	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217009762	minor groove reading motif; other site
447217009763	helix-hairpin-helix signature motif; other site
447217009764	substrate binding pocket [chemical binding]; other site
447217009765	active site
447217009766	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
447217009767	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
447217009768	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217009769	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
447217009770	tetramer interfaces [polypeptide binding]; other site
447217009771	binuclear metal-binding site [ion binding]; other site
447217009772	competence damage-inducible protein A; Provisional; Region: PRK00549
447217009773	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
447217009774	putative MPT binding site; other site
447217009775	Competence-damaged protein; Region: CinA; cl00666
447217009776	Protein of unknown function (DUF1285); Region: DUF1285; cl01571
447217009777	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217009778	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
447217009779	Surface antigen; Region: Bac_surface_Ag; cl03097
447217009780	recombinase A; Provisional; Region: recA; PRK09354
447217009781	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
447217009782	hexamer interface [polypeptide binding]; other site
447217009783	Walker A motif; other site
447217009784	ATP binding site [chemical binding]; other site
447217009785	Walker B motif; other site
447217009786	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
447217009787	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
447217009788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009789	Walker A motif; other site
447217009790	ATP binding site [chemical binding]; other site
447217009791	Walker B motif; other site
447217009792	arginine finger; other site
447217009793	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
447217009794	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
447217009795	Fe-S cluster binding site [ion binding]; other site
447217009796	DNA binding site [nucleotide binding]
447217009797	active site
447217009798	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217009799	G1 box; other site
447217009800	GTP/Mg2+ binding site [chemical binding]; other site
447217009801	G2 box; other site
447217009802	Switch I region; other site
447217009803	G3 box; other site
447217009804	Switch II region; other site
447217009805	G4 box; other site
447217009806	G5 box; other site
447217009807	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
447217009808	recombination protein RecR; Reviewed; Region: recR; PRK00076
447217009809	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
447217009810	RecR protein; Region: RecR; pfam02132
447217009811	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
447217009812	putative active site [active]
447217009813	putative metal-binding site [ion binding]; other site
447217009814	tetramer interface [polypeptide binding]; other site
447217009815	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
447217009816	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
447217009817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009818	Walker A motif; other site
447217009819	ATP binding site [chemical binding]; other site
447217009820	Walker B motif; other site
447217009821	arginine finger; other site
447217009822	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
447217009823	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
447217009824	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
447217009825	nucleoside/Zn binding site; other site
447217009826	dimer interface [polypeptide binding]; other site
447217009827	catalytic motif [active]
447217009828	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
447217009829	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217009830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217009831	FeS/SAM binding site; other site
447217009832	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217009833	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217009834	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217009835	GAF domain; Region: GAF; cl15785
447217009836	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217009837	ligand binding site [chemical binding]; other site
447217009838	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
447217009839	TPR repeat; Region: TPR_11; pfam13414
447217009840	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217009841	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217009842	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217009843	active site
447217009844	ATP binding site [chemical binding]; other site
447217009845	substrate binding site [chemical binding]; other site
447217009846	activation loop (A-loop); other site
447217009847	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217009848	phosphopeptide binding site; other site
447217009849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217009850	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217009851	Walker A motif; other site
447217009852	ATP binding site [chemical binding]; other site
447217009853	Walker B motif; other site
447217009854	arginine finger; other site
447217009855	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
447217009856	DNA binding residues [nucleotide binding]
447217009857	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
447217009858	active site
447217009859	phosphorylation site [posttranslational modification]
447217009860	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217009861	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217009862	NADH dehydrogenase; Region: NADHdh; cl00469
447217009863	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
447217009864	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
447217009865	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
447217009866	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
447217009867	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
447217009868	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
447217009869	4Fe-4S binding domain; Region: Fer4; cl02805
447217009870	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
447217009871	PspC domain; Region: PspC; cl00864
447217009872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217009873	S-adenosylmethionine binding site [chemical binding]; other site
447217009874	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217009875	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
447217009876	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
447217009877	active site
447217009878	aconitate hydratase; Validated; Region: PRK09277
447217009879	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
447217009880	substrate binding site [chemical binding]; other site
447217009881	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
447217009882	ligand binding site [chemical binding]; other site
447217009883	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
447217009884	substrate binding site [chemical binding]; other site
447217009885	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
447217009886	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
447217009887	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
447217009888	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
447217009889	oxalacetate binding site [chemical binding]; other site
447217009890	citrylCoA binding site [chemical binding]; other site
447217009891	coenzyme A binding site [chemical binding]; other site
447217009892	catalytic triad [active]
447217009893	Peptidase family M23; Region: Peptidase_M23; pfam01551
447217009894	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
447217009895	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217009896	RNA binding site [nucleotide binding]; other site
447217009897	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
447217009898	RNA binding site [nucleotide binding]; other site
447217009899	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
447217009900	RNA binding site [nucleotide binding]; other site
447217009901	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
447217009902	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
447217009903	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
447217009904	catalytic site [active]
447217009905	active site
447217009906	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
447217009907	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
447217009908	active site
447217009909	substrate-binding site [chemical binding]; other site
447217009910	metal-binding site [ion binding]
447217009911	GTP binding site [chemical binding]; other site
447217009912	NRDE protein; Region: NRDE; cl01315
447217009913	Protein of unknown function (DUF971); Region: DUF971; cl01414
447217009914	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
447217009915	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
447217009916	SmpB-tmRNA interface; other site
447217009917	Pantoate-beta-alanine ligase; Region: PanC; cd00560
447217009918	pantoate--beta-alanine ligase; Region: panC; TIGR00018
447217009919	active site
447217009920	ATP-binding site [chemical binding]; other site
447217009921	pantoate-binding site; other site
447217009922	HXXH motif; other site
447217009923	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
447217009924	oligomerization interface [polypeptide binding]; other site
447217009925	active site
447217009926	metal binding site [ion binding]; metal-binding site
447217009927	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
447217009928	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
447217009929	Substrate-binding site [chemical binding]; other site
447217009930	Substrate specificity [chemical binding]; other site
447217009931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217009933	UGMP family protein; Validated; Region: PRK09604
447217009934	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
447217009935	Response regulator receiver domain; Region: Response_reg; pfam00072
447217009936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217009937	active site
447217009938	phosphorylation site [posttranslational modification]
447217009939	intermolecular recognition site; other site
447217009940	dimerization interface [polypeptide binding]; other site
447217009941	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217009942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217009943	TPR motif; other site
447217009944	binding surface
447217009945	Tetratricopeptide repeat; Region: TPR_16; pfam13432
447217009946	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217009947	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
447217009948	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217009949	HSP70 interaction site [polypeptide binding]; other site
447217009950	Protein phosphatase 2C; Region: PP2C; pfam00481
447217009951	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
447217009952	active site
447217009953	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
447217009954	active site
447217009955	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
447217009956	MFS_1 like family; Region: MFS_1_like; pfam12832
447217009957	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
447217009958	active site
447217009959	substrate binding site [chemical binding]; other site
447217009960	catalytic site [active]
447217009961	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
447217009962	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
447217009963	ligand binding site [chemical binding]; other site
447217009964	flexible hinge region; other site
447217009965	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
447217009966	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
447217009967	metal binding triad; other site
447217009968	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217009969	Sodium:solute symporter family; Region: SSF; cl00456
447217009970	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
447217009971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217009972	putative substrate translocation pore; other site
447217009973	metabolite-proton symporter; Region: 2A0106; TIGR00883
447217009974	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217009975	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217009976	active site
447217009977	ATP binding site [chemical binding]; other site
447217009978	substrate binding site [chemical binding]; other site
447217009979	activation loop (A-loop); other site
447217009980	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
447217009981	Ligand Binding Site [chemical binding]; other site
447217009982	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217009983	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217009984	Protein of unknown function, DUF485; Region: DUF485; cl01231
447217009985	Sodium:solute symporter family; Region: SSF; cl00456
447217009986	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
447217009987	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
447217009988	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217009989	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217009990	dimer interface [polypeptide binding]; other site
447217009991	putative CheW interface [polypeptide binding]; other site
447217009992	Phosphotransferase enzyme family; Region: APH; pfam01636
447217009993	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
447217009994	active site
447217009995	ATP binding site [chemical binding]; other site
447217009996	substrate binding site [chemical binding]; other site
447217009997	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
447217009998	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
447217009999	dimer interface [polypeptide binding]; other site
447217010000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010001	catalytic residue [active]
447217010002	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
447217010003	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
447217010004	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
447217010005	homodimer interface [polypeptide binding]; other site
447217010006	substrate-cofactor binding pocket; other site
447217010007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010008	catalytic residue [active]
447217010009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010010	putative substrate translocation pore; other site
447217010011	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
447217010012	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
447217010013	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
447217010014	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
447217010015	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
447217010016	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
447217010017	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
447217010018	catalytic site [active]
447217010019	active site
447217010020	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
447217010021	Cache domain; Region: Cache_2; cl07034
447217010022	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217010023	dimer interface [polypeptide binding]; other site
447217010024	putative CheW interface [polypeptide binding]; other site
447217010025	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
447217010026	active site
447217010027	FMN binding site [chemical binding]; other site
447217010028	substrate binding site [chemical binding]; other site
447217010029	homotetramer interface [polypeptide binding]; other site
447217010030	catalytic residue [active]
447217010031	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
447217010032	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
447217010033	PUA domain; Region: PUA; cl00607
447217010034	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
447217010035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
447217010036	S-adenosylmethionine binding site [chemical binding]; other site
447217010037	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
447217010038	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
447217010039	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
447217010040	active site
447217010041	PAS domain; Region: PAS_9; pfam13426
447217010042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010043	putative active site [active]
447217010044	heme pocket [chemical binding]; other site
447217010045	GAF domain; Region: GAF; cl15785
447217010046	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
447217010047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217010048	dimer interface [polypeptide binding]; other site
447217010049	phosphorylation site [posttranslational modification]
447217010050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010051	ATP binding site [chemical binding]; other site
447217010052	Mg2+ binding site [ion binding]; other site
447217010053	G-X-G motif; other site
447217010054	O-methyltransferase; Region: Methyltransf_3; pfam01596
447217010055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010056	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217010057	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
447217010058	motif 1; other site
447217010059	dimer interface [polypeptide binding]; other site
447217010060	active site
447217010061	motif 2; other site
447217010062	motif 3; other site
447217010063	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217010064	Zn binding site [ion binding]; other site
447217010065	PAS domain; Region: PAS_9; pfam13426
447217010066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010067	putative active site [active]
447217010068	heme pocket [chemical binding]; other site
447217010069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217010070	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217010071	putative active site [active]
447217010072	heme pocket [chemical binding]; other site
447217010073	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010074	dimer interface [polypeptide binding]; other site
447217010075	phosphorylation site [posttranslational modification]
447217010076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010077	ATP binding site [chemical binding]; other site
447217010078	Mg2+ binding site [ion binding]; other site
447217010079	G-X-G motif; other site
447217010080	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217010081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010082	active site
447217010083	phosphorylation site [posttranslational modification]
447217010084	intermolecular recognition site; other site
447217010085	dimerization interface [polypeptide binding]; other site
447217010086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010087	Walker A motif; other site
447217010088	ATP binding site [chemical binding]; other site
447217010089	Walker B motif; other site
447217010090	arginine finger; other site
447217010091	Helix-turn-helix domains; Region: HTH; cl00088
447217010092	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
447217010093	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
447217010094	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217010095	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
447217010096	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217010097	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
447217010098	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217010099	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
447217010100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010101	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217010102	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010103	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217010104	DNA binding residues [nucleotide binding]
447217010105	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
447217010106	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
447217010107	glycogen binding site [chemical binding]; other site
447217010108	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010109	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010110	active site
447217010111	ATP binding site [chemical binding]; other site
447217010112	substrate binding site [chemical binding]; other site
447217010113	activation loop (A-loop); other site
447217010114	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217010115	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217010116	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
447217010117	phosphopeptide binding site; other site
447217010118	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
447217010119	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
447217010120	substrate binding site [chemical binding]; other site
447217010121	oxyanion hole (OAH) forming residues; other site
447217010122	trimer interface [polypeptide binding]; other site
447217010123	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
447217010124	carboxyltransferase (CT) interaction site; other site
447217010125	biotinylation site [posttranslational modification]; other site
447217010126	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
447217010127	CoenzymeA binding site [chemical binding]; other site
447217010128	subunit interaction site [polypeptide binding]; other site
447217010129	PHB binding site; other site
447217010130	PilZ domain; Region: PilZ; cl01260
447217010131	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010133	active site
447217010134	phosphorylation site [posttranslational modification]
447217010135	intermolecular recognition site; other site
447217010136	dimerization interface [polypeptide binding]; other site
447217010137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010138	NAD(P) binding site [chemical binding]; other site
447217010139	active site
447217010140	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
447217010141	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217010142	ligand binding site [chemical binding]; other site
447217010143	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
447217010144	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
447217010145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010146	catalytic residue [active]
447217010147	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
447217010148	NMT1-like family; Region: NMT1_2; cl15260
447217010149	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
447217010150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217010151	putative PBP binding loops; other site
447217010152	dimer interface [polypeptide binding]; other site
447217010153	ABC-ATPase subunit interface; other site
447217010154	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
447217010155	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
447217010156	Walker A/P-loop; other site
447217010157	ATP binding site [chemical binding]; other site
447217010158	Q-loop/lid; other site
447217010159	ABC transporter signature motif; other site
447217010160	Walker B; other site
447217010161	D-loop; other site
447217010162	H-loop/switch region; other site
447217010163	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
447217010164	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
447217010165	[4Fe-4S] binding site [ion binding]; other site
447217010166	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217010167	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
447217010168	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
447217010169	molybdopterin cofactor binding site; other site
447217010170	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
447217010171	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
447217010172	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
447217010173	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
447217010174	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
447217010175	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
447217010176	short chain dehydrogenase; Provisional; Region: PRK08278
447217010177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010178	NAD(P) binding site [chemical binding]; other site
447217010179	active site
447217010180	cell division protein MraZ; Reviewed; Region: PRK00326
447217010181	MraZ protein; Region: MraZ; pfam02381
447217010182	MraZ protein; Region: MraZ; pfam02381
447217010183	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
447217010184	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
447217010185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010186	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
447217010187	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
447217010188	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217010189	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
447217010190	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
447217010191	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010192	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010193	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010194	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010195	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
447217010196	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010197	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
447217010198	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
447217010199	Mg++ binding site [ion binding]; other site
447217010200	putative catalytic motif [active]
447217010201	putative substrate binding site [chemical binding]; other site
447217010202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010203	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
447217010204	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010205	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010206	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
447217010207	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
447217010208	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
447217010209	active site
447217010210	homodimer interface [polypeptide binding]; other site
447217010211	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
447217010212	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
447217010213	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
447217010214	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
447217010215	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652
447217010216	FAD binding domain; Region: FAD_binding_4; pfam01565
447217010217	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
447217010218	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
447217010219	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
447217010220	ATP-grasp domain; Region: ATP-grasp_4; cl03087
447217010221	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217010222	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217010223	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217010224	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
447217010225	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
447217010226	Cell division protein FtsQ; Region: FtsQ; pfam03799
447217010227	cell division protein FtsA; Region: ftsA; TIGR01174
447217010228	Cell division protein FtsA; Region: FtsA; cl11496
447217010229	Cell division protein FtsA; Region: FtsA; cl11496
447217010230	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
447217010231	cell division protein FtsZ; Validated; Region: PRK09330
447217010232	nucleotide binding site [chemical binding]; other site
447217010233	SulA interaction site; other site
447217010234	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217010235	Putative esterase; Region: Esterase; pfam00756
447217010236	Putative esterase; Region: Esterase; pfam00756
447217010237	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
447217010238	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
447217010239	motif 1; other site
447217010240	active site
447217010241	motif 2; other site
447217010242	motif 3; other site
447217010243	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
447217010244	DHHA1 domain; Region: DHHA1; pfam02272
447217010245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010246	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217010247	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217010248	Walker A/P-loop; other site
447217010249	ATP binding site [chemical binding]; other site
447217010250	Q-loop/lid; other site
447217010251	ABC transporter signature motif; other site
447217010252	Walker B; other site
447217010253	D-loop; other site
447217010254	H-loop/switch region; other site
447217010255	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
447217010256	N-acetyl-D-glucosamine binding site [chemical binding]; other site
447217010257	catalytic residue [active]
447217010258	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
447217010259	putative peptidoglycan binding site; other site
447217010260	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
447217010261	putative peptidoglycan binding site; other site
447217010262	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
447217010263	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
447217010264	FMN binding site [chemical binding]; other site
447217010265	active site
447217010266	catalytic residues [active]
447217010267	substrate binding site [chemical binding]; other site
447217010268	Helix-turn-helix domains; Region: HTH; cl00088
447217010269	ZIP Zinc transporter; Region: Zip; pfam02535
447217010270	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
447217010271	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
447217010272	Helix-turn-helix domains; Region: HTH; cl00088
447217010273	DNA binding residues [nucleotide binding]
447217010274	dimerization interface [polypeptide binding]; other site
447217010275	putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900
447217010276	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
447217010277	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
447217010278	protein binding site [polypeptide binding]; other site
447217010279	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
447217010280	Catalytic dyad [active]
447217010281	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
447217010282	Ligand Binding Site [chemical binding]; other site
447217010283	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
447217010284	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
447217010285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217010286	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
447217010287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010288	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
447217010289	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
447217010290	metal binding site 2 [ion binding]; metal-binding site
447217010291	putative DNA binding helix; other site
447217010292	metal binding site 1 [ion binding]; metal-binding site
447217010293	dimer interface [polypeptide binding]; other site
447217010294	structural Zn2+ binding site [ion binding]; other site
447217010295	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217010296	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
447217010297	dimer interface [polypeptide binding]; other site
447217010298	ssDNA binding site [nucleotide binding]; other site
447217010299	tetramer (dimer of dimers) interface [polypeptide binding]; other site
447217010300	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
447217010301	TPR repeat; Region: TPR_11; pfam13414
447217010302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217010303	binding surface
447217010304	TPR motif; other site
447217010305	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
447217010306	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
447217010307	motif II; other site
447217010308	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217010309	dimerization interface [polypeptide binding]; other site
447217010310	putative DNA binding site [nucleotide binding]; other site
447217010311	putative Zn2+ binding site [ion binding]; other site
447217010312	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
447217010313	putative hydrophobic ligand binding site [chemical binding]; other site
447217010314	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
447217010315	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
447217010316	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
447217010317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
447217010318	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
447217010319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
447217010320	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
447217010321	active site
447217010322	dimer interface [polypeptide binding]; other site
447217010323	Helix-turn-helix domains; Region: HTH; cl00088
447217010324	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
447217010325	Helix-turn-helix domain; Region: HTH_18; pfam12833
447217010326	Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763
447217010327	Family description; Region: VCBS; pfam13517
447217010328	Family description; Region: VCBS; pfam13517
447217010329	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
447217010330	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217010331	hypothetical protein; Reviewed; Region: PRK00024
447217010332	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
447217010333	MPN+ (JAMM) motif; other site
447217010334	Zinc-binding site [ion binding]; other site
447217010335	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
447217010336	Peptidase family C69; Region: Peptidase_C69; pfam03577
447217010337	YceI-like domain; Region: YceI; cl01001
447217010338	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
447217010339	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
447217010340	metal binding site [ion binding]; metal-binding site
447217010341	putative dimer interface [polypeptide binding]; other site
447217010342	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
447217010343	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
447217010344	trimer interface [polypeptide binding]; other site
447217010345	active site
447217010346	substrate binding site [chemical binding]; other site
447217010347	CoA binding site [chemical binding]; other site
447217010348	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
447217010349	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217010350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010351	homodimer interface [polypeptide binding]; other site
447217010352	catalytic residue [active]
447217010353	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
447217010354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217010355	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
447217010356	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
447217010357	glutathione s-transferase; Provisional; Region: PTZ00057
447217010358	GSH binding site (G-site) [chemical binding]; other site
447217010359	C-terminal domain interface [polypeptide binding]; other site
447217010360	dimer interface [polypeptide binding]; other site
447217010361	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
447217010362	dimer interface [polypeptide binding]; other site
447217010363	N-terminal domain interface [polypeptide binding]; other site
447217010364	substrate binding pocket (H-site) [chemical binding]; other site
447217010365	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217010366	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217010367	P-loop; other site
447217010368	Magnesium ion binding site [ion binding]; other site
447217010369	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217010370	Magnesium ion binding site [ion binding]; other site
447217010371	HEAT repeats; Region: HEAT_2; pfam13646
447217010372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217010374	putative substrate translocation pore; other site
447217010375	FOG: CBS domain [General function prediction only]; Region: COG0517
447217010376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
447217010377	Transporter associated domain; Region: CorC_HlyC; cl08393
447217010378	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
447217010379	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
447217010380	putative active site [active]
447217010381	catalytic triad [active]
447217010382	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
447217010383	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010385	active site
447217010386	phosphorylation site [posttranslational modification]
447217010387	intermolecular recognition site; other site
447217010388	dimerization interface [polypeptide binding]; other site
447217010389	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
447217010390	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
447217010391	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
447217010392	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
447217010393	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
447217010394	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217010395	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
447217010396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010397	NAD(P) binding site [chemical binding]; other site
447217010398	active site
447217010399	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
447217010400	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
447217010401	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217010403	seryl-tRNA synthetase; Provisional; Region: PRK05431
447217010404	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
447217010405	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
447217010406	dimer interface [polypeptide binding]; other site
447217010407	active site
447217010408	motif 1; other site
447217010409	motif 2; other site
447217010410	motif 3; other site
447217010411	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
447217010412	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217010413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010414	dimer interface [polypeptide binding]; other site
447217010415	phosphorylation site [posttranslational modification]
447217010416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010417	ATP binding site [chemical binding]; other site
447217010418	Mg2+ binding site [ion binding]; other site
447217010419	G-X-G motif; other site
447217010420	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
447217010421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010422	active site
447217010423	phosphorylation site [posttranslational modification]
447217010424	intermolecular recognition site; other site
447217010425	dimerization interface [polypeptide binding]; other site
447217010426	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217010427	DNA binding site [nucleotide binding]
447217010428	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217010429	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217010430	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217010431	Outer membrane efflux protein; Region: OEP; pfam02321
447217010432	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
447217010433	active site
447217010434	Int/Topo IB signature motif; other site
447217010435	DNA binding site [nucleotide binding]
447217010436	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217010437	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217010438	Integrase core domain; Region: rve; cl01316
447217010439	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217010440	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217010441	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217010442	active site
447217010443	ATP binding site [chemical binding]; other site
447217010444	substrate binding site [chemical binding]; other site
447217010445	activation loop (A-loop); other site
447217010446	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
447217010447	Z1 domain; Region: Z1; pfam10593
447217010448	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
447217010449	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
447217010450	AAA-like domain; Region: AAA_10; pfam12846
447217010451	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
447217010452	homodimer interface [polypeptide binding]; other site
447217010453	putative active site [active]
447217010454	catalytic site [active]
447217010455	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
447217010456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217010457	Walker A motif; other site
447217010458	ATP binding site [chemical binding]; other site
447217010459	Walker B motif; other site
447217010460	arginine finger; other site
447217010461	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
447217010462	non-specific DNA binding site [nucleotide binding]; other site
447217010463	salt bridge; other site
447217010464	sequence-specific DNA binding site [nucleotide binding]; other site
447217010465	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
447217010466	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
447217010467	minor groove reading motif; other site
447217010468	helix-hairpin-helix signature motif; other site
447217010469	substrate binding pocket [chemical binding]; other site
447217010470	active site
447217010471	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
447217010472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010473	cofactor binding site; other site
447217010474	DNA binding site [nucleotide binding]
447217010475	substrate interaction site [chemical binding]; other site
447217010476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
447217010478	sensor protein KdpD; Provisional; Region: PRK10490
447217010479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010480	ATP binding site [chemical binding]; other site
447217010481	Mg2+ binding site [ion binding]; other site
447217010482	G-X-G motif; other site
447217010483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010484	cofactor binding site; other site
447217010485	DNA binding site [nucleotide binding]
447217010486	substrate interaction site [chemical binding]; other site
447217010487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010488	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
447217010489	active site
447217010490	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
447217010491	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217010492	Integrase core domain; Region: rve; cl01316
447217010493	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
447217010494	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
447217010495	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217010496	active site
447217010497	metal binding site [ion binding]; metal-binding site
447217010498	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217010499	metal ion-dependent adhesion site (MIDAS); other site
447217010500	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217010501	Walker A motif; other site
447217010502	ATP binding site [chemical binding]; other site
447217010503	Walker B motif; other site
447217010504	Protein of unknown function (DUF429); Region: DUF429; cl12046
447217010505	Protein of unknown function DUF91; Region: DUF91; cl00709
447217010506	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
447217010507	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217010508	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
447217010509	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217010510	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
447217010511	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
447217010512	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217010513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
447217010514	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
447217010515	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
447217010516	ATP binding site [chemical binding]; other site
447217010517	putative Mg++ binding site [ion binding]; other site
447217010518	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217010519	nucleotide binding region [chemical binding]; other site
447217010520	ATP-binding site [chemical binding]; other site
447217010521	DEAD/H associated; Region: DEAD_assoc; pfam08494
447217010522	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
447217010523	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
447217010524	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
447217010525	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
447217010526	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
447217010527	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
447217010528	Family description; Region: UvrD_C_2; cl15862
447217010529	SEC-C motif; Region: SEC-C; pfam02810
447217010530	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
447217010531	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217010532	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
447217010533	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
447217010534	B12 binding site [chemical binding]; other site
447217010535	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
447217010536	substrate-cofactor binding pocket; other site
447217010537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010538	catalytic residue [active]
447217010539	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
447217010540	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
447217010541	chorismate binding enzyme; Region: Chorismate_bind; cl10555
447217010542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010543	phosphorylation site [posttranslational modification]
447217010544	intermolecular recognition site; other site
447217010545	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
447217010546	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
447217010547	active site
447217010548	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
447217010549	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
447217010550	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217010551	dimerization interface [polypeptide binding]; other site
447217010552	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217010553	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217010554	dimer interface [polypeptide binding]; other site
447217010555	putative CheW interface [polypeptide binding]; other site
447217010556	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
447217010557	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
447217010558	active site
447217010559	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217010560	active site
447217010561	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
447217010562	putative NADP binding site [chemical binding]; other site
447217010563	active site
447217010564	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217010565	active site
447217010566	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
447217010567	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
447217010568	active site
447217010569	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
447217010570	Acyl transferase domain; Region: Acyl_transf_1; cl08282
447217010571	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
447217010572	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217010573	Predicted transcriptional regulator [Transcription]; Region: COG2378
447217010574	Helix-turn-helix domains; Region: HTH; cl00088
447217010575	WYL domain; Region: WYL; cl14852
447217010576	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
447217010577	active site
447217010578	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
447217010579	Acetokinase family; Region: Acetate_kinase; cl01029
447217010580	propionate/acetate kinase; Provisional; Region: PRK12379
447217010581	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
447217010582	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217010583	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010584	Predicted permeases [General function prediction only]; Region: COG0701
447217010585	Predicted permease; Region: DUF318; pfam03773
447217010586	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
447217010587	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
447217010588	catalytic residues [active]
447217010589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
447217010590	dimerization interface [polypeptide binding]; other site
447217010591	putative DNA binding site [nucleotide binding]; other site
447217010592	putative Zn2+ binding site [ion binding]; other site
447217010593	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
447217010594	Membrane transport protein; Region: Mem_trans; cl09117
447217010595	Low molecular weight phosphatase family; Region: LMWPc; cd00115
447217010596	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
447217010597	active site
447217010598	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
447217010599	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
447217010600	putative hydrophobic ligand binding site [chemical binding]; other site
447217010601	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217010602	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
447217010603	Walker A/P-loop; other site
447217010604	ATP binding site [chemical binding]; other site
447217010605	Q-loop/lid; other site
447217010606	ABC transporter signature motif; other site
447217010607	Walker B; other site
447217010608	D-loop; other site
447217010609	H-loop/switch region; other site
447217010610	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
447217010611	ABC-2 type transporter; Region: ABC2_membrane; cl11417
447217010612	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
447217010613	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217010614	Walker A/P-loop; other site
447217010615	ATP binding site [chemical binding]; other site
447217010616	Q-loop/lid; other site
447217010617	ABC transporter signature motif; other site
447217010618	Walker B; other site
447217010619	D-loop; other site
447217010620	H-loop/switch region; other site
447217010621	ABC transporter; Region: ABC_tran_2; pfam12848
447217010622	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217010623	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
447217010624	putative dimer interface [polypeptide binding]; other site
447217010625	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217010626	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
447217010627	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
447217010628	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
447217010629	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
447217010630	benzoate transport; Region: 2A0115; TIGR00895
447217010631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010632	putative substrate translocation pore; other site
447217010633	RmuC family; Region: RmuC; pfam02646
447217010634	WYL domain; Region: WYL; cl14852
447217010635	WYL domain; Region: WYL; cl14852
447217010636	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
447217010637	putative acyl-acceptor binding pocket; other site
447217010638	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217010639	Amidase; Region: Amidase; cl11426
447217010640	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
447217010641	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
447217010642	putative DNA binding site [nucleotide binding]; other site
447217010643	catalytic residue [active]
447217010644	putative H2TH interface [polypeptide binding]; other site
447217010645	putative catalytic residues [active]
447217010646	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
447217010647	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
447217010648	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
447217010649	Malic enzyme, N-terminal domain; Region: malic; pfam00390
447217010650	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
447217010651	putative NAD(P) binding site [chemical binding]; other site
447217010652	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
447217010653	homoserine dehydrogenase; Provisional; Region: PRK06270
447217010654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010655	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
447217010656	Domain of unknown function DUF302; Region: DUF302; cl01364
447217010657	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
447217010658	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217010659	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217010660	FtsX-like permease family; Region: FtsX; cl15850
447217010661	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
447217010662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217010663	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217010664	Walker A/P-loop; other site
447217010665	ATP binding site [chemical binding]; other site
447217010666	Q-loop/lid; other site
447217010667	ABC transporter signature motif; other site
447217010668	Walker B; other site
447217010669	D-loop; other site
447217010670	H-loop/switch region; other site
447217010671	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
447217010672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
447217010673	Smr domain; Region: Smr; cl02619
447217010674	Outer membrane efflux protein; Region: OEP; pfam02321
447217010675	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217010676	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217010677	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
447217010678	Protein export membrane protein; Region: SecD_SecF; cl14618
447217010679	MgtE intracellular N domain; Region: MgtE_N; cl15244
447217010680	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
447217010681	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
447217010682	Divalent cation transporter; Region: MgtE; cl00786
447217010683	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
447217010684	phosphate binding site [ion binding]; other site
447217010685	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217010686	prolyl-tRNA synthetase; Provisional; Region: PRK09194
447217010687	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
447217010688	dimer interface [polypeptide binding]; other site
447217010689	motif 1; other site
447217010690	active site
447217010691	motif 2; other site
447217010692	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
447217010693	putative deacylase active site [active]
447217010694	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
447217010695	active site
447217010696	motif 3; other site
447217010697	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
447217010698	anticodon binding site; other site
447217010699	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
447217010700	GcpE protein; Region: GcpE; pfam04551
447217010701	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
447217010702	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
447217010703	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
447217010704	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217010705	catalytic residues [active]
447217010706	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
447217010707	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
447217010708	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
447217010709	trimer interface [polypeptide binding]; other site
447217010710	dimer interface [polypeptide binding]; other site
447217010711	putative active site [active]
447217010712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010713	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217010714	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
447217010715	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
447217010716	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
447217010717	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
447217010718	Substrate binding site; other site
447217010719	Mg++ binding site; other site
447217010720	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
447217010721	active site
447217010722	substrate binding site [chemical binding]; other site
447217010723	CoA binding site [chemical binding]; other site
447217010724	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
447217010725	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
447217010726	glutaminase active site [active]
447217010727	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
447217010728	dimer interface [polypeptide binding]; other site
447217010729	active site
447217010730	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
447217010731	dimer interface [polypeptide binding]; other site
447217010732	active site
447217010733	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
447217010734	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
447217010735	Protein of unknown function (DUF2378); Region: DUF2378; cl15288
447217010736	recombinase A; Provisional; Region: recA; PRK09354
447217010737	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
447217010738	hexamer interface [polypeptide binding]; other site
447217010739	Walker A motif; other site
447217010740	ATP binding site [chemical binding]; other site
447217010741	Walker B motif; other site
447217010742	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
447217010743	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
447217010744	MOFRL family; Region: MOFRL; pfam05161
447217010745	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
447217010746	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
447217010747	putative active site [active]
447217010748	substrate binding site [chemical binding]; other site
447217010749	putative cosubstrate binding site; other site
447217010750	catalytic site [active]
447217010751	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
447217010752	substrate binding site [chemical binding]; other site
447217010753	16S rRNA methyltransferase B; Provisional; Region: PRK14902
447217010754	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
447217010755	putative RNA binding site [nucleotide binding]; other site
447217010756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217010757	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
447217010758	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
447217010759	substrate binding site [chemical binding]; other site
447217010760	hexamer interface [polypeptide binding]; other site
447217010761	metal binding site [ion binding]; metal-binding site
447217010762	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
447217010763	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
447217010764	ligand binding site [chemical binding]; other site
447217010765	active site
447217010766	Response regulator receiver domain; Region: Response_reg; pfam00072
447217010767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010768	active site
447217010769	phosphorylation site [posttranslational modification]
447217010770	intermolecular recognition site; other site
447217010771	dimerization interface [polypeptide binding]; other site
447217010772	TMAO/DMSO reductase; Reviewed; Region: PRK05363
447217010773	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
447217010774	Moco binding site; other site
447217010775	metal coordination site [ion binding]; other site
447217010776	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
447217010777	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
447217010778	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
447217010779	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
447217010780	AAA domain; Region: AAA_33; pfam13671
447217010781	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217010782	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
447217010783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010784	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
447217010785	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
447217010786	putative active site [active]
447217010787	catalytic site [active]
447217010788	putative metal binding site [ion binding]; other site
447217010789	Helix-turn-helix domains; Region: HTH; cl00088
447217010790	Helix-turn-helix domains; Region: HTH; cl00088
447217010791	Integrase core domain; Region: rve; cl01316
447217010792	Integrase core domain; Region: rve_3; cl15866
447217010793	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217010794	active site
447217010795	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
447217010796	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217010797	Walker A/P-loop; other site
447217010798	ATP binding site [chemical binding]; other site
447217010799	Q-loop/lid; other site
447217010800	ABC transporter signature motif; other site
447217010801	Walker B; other site
447217010802	D-loop; other site
447217010803	H-loop/switch region; other site
447217010804	ABC transporter; Region: ABC_tran_2; pfam12848
447217010805	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
447217010806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217010808	putative substrate translocation pore; other site
447217010809	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
447217010810	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
447217010811	Pyocin large subunit [General function prediction only]; Region: COG5529
447217010812	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
447217010813	putative metal binding site; other site
447217010814	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217010815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010816	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
447217010817	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
447217010818	Walker A/P-loop; other site
447217010819	ATP binding site [chemical binding]; other site
447217010820	Q-loop/lid; other site
447217010821	ABC transporter signature motif; other site
447217010822	Walker B; other site
447217010823	D-loop; other site
447217010824	H-loop/switch region; other site
447217010825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
447217010826	NMT1-like family; Region: NMT1_2; cl15260
447217010827	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
447217010828	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
447217010829	NlpC/P60 family; Region: NLPC_P60; cl11438
447217010830	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
447217010831	active site
447217010832	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
447217010833	PhoU domain; Region: PhoU; pfam01895
447217010834	PhoU domain; Region: PhoU; pfam01895
447217010835	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
447217010836	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
447217010837	Walker A/P-loop; other site
447217010838	ATP binding site [chemical binding]; other site
447217010839	Q-loop/lid; other site
447217010840	ABC transporter signature motif; other site
447217010841	Walker B; other site
447217010842	D-loop; other site
447217010843	H-loop/switch region; other site
447217010844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217010845	dimer interface [polypeptide binding]; other site
447217010846	conserved gate region; other site
447217010847	putative PBP binding loops; other site
447217010848	ABC-ATPase subunit interface; other site
447217010849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217010850	dimer interface [polypeptide binding]; other site
447217010851	conserved gate region; other site
447217010852	putative PBP binding loops; other site
447217010853	ABC-ATPase subunit interface; other site
447217010854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217010855	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
447217010856	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
447217010857	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217010858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217010859	dimer interface [polypeptide binding]; other site
447217010860	phosphorylation site [posttranslational modification]
447217010861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217010862	ATP binding site [chemical binding]; other site
447217010863	Mg2+ binding site [ion binding]; other site
447217010864	G-X-G motif; other site
447217010865	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
447217010866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217010867	active site
447217010868	phosphorylation site [posttranslational modification]
447217010869	intermolecular recognition site; other site
447217010870	dimerization interface [polypeptide binding]; other site
447217010871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
447217010872	DNA binding site [nucleotide binding]
447217010873	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217010874	ligand binding site [chemical binding]; other site
447217010875	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
447217010876	metal binding site [ion binding]; metal-binding site
447217010877	active site
447217010878	I-site; other site
447217010879	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
447217010880	THUMP domain; Region: THUMP; cl12076
447217010881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217010882	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010884	putative substrate translocation pore; other site
447217010885	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217010886	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
447217010887	CoenzymeA binding site [chemical binding]; other site
447217010888	subunit interaction site [polypeptide binding]; other site
447217010889	PHB binding site; other site
447217010890	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
447217010891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
447217010892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
447217010893	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217010894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217010895	putative substrate translocation pore; other site
447217010896	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
447217010897	active site residue [active]
447217010898	Protein of unknown function (DUF423); Region: DUF423; cl01008
447217010899	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
447217010900	aromatic arch; other site
447217010901	DCoH dimer interaction site [polypeptide binding]; other site
447217010902	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
447217010903	DCoH tetramer interaction site [polypeptide binding]; other site
447217010904	substrate binding site [chemical binding]; other site
447217010905	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
447217010906	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
447217010907	putative active site [active]
447217010908	putative metal binding site [ion binding]; other site
447217010909	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217010910	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217010911	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
447217010912	NAD-dependent deacetylase; Provisional; Region: PRK00481
447217010913	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
447217010914	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
447217010915	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
447217010916	intersubunit interface [polypeptide binding]; other site
447217010917	Protein of unknown function (DUF525); Region: DUF525; cl01119
447217010918	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
447217010919	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
447217010920	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217010921	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217010922	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
447217010923	active site
447217010924	catalytic site [active]
447217010925	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
447217010926	active site
447217010927	catalytic site [active]
447217010928	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
447217010929	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
447217010930	catalytic residues [active]
447217010931	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217010932	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217010933	active site
447217010934	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
447217010935	pyruvate phosphate dikinase; Provisional; Region: PRK09279
447217010936	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
447217010937	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
447217010938	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
447217010939	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
447217010940	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
447217010941	Ligand Binding Site [chemical binding]; other site
447217010942	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217010943	CPxP  motif; other site
447217010944	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010945	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217010946	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010947	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217010948	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217010949	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
447217010950	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
447217010951	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
447217010952	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
447217010953	tetramerization interface [polypeptide binding]; other site
447217010954	active site
447217010955	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
447217010956	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
447217010957	chorismate binding enzyme; Region: Chorismate_bind; cl10555
447217010958	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
447217010959	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
447217010960	glutamine binding [chemical binding]; other site
447217010961	catalytic triad [active]
447217010962	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
447217010963	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
447217010964	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
447217010965	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
447217010966	active site
447217010967	ribulose/triose binding site [chemical binding]; other site
447217010968	phosphate binding site [ion binding]; other site
447217010969	substrate (anthranilate) binding pocket [chemical binding]; other site
447217010970	product (indole) binding pocket [chemical binding]; other site
447217010971	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
447217010972	active site
447217010973	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
447217010974	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
447217010975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217010976	catalytic residue [active]
447217010977	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
447217010978	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
447217010979	substrate binding site [chemical binding]; other site
447217010980	active site
447217010981	catalytic residues [active]
447217010982	heterodimer interface [polypeptide binding]; other site
447217010983	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
447217010984	NeuB family; Region: NeuB; cl00496
447217010985	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
447217010986	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217010987	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
447217010988	Helix-turn-helix domains; Region: HTH; cl00088
447217010989	EamA-like transporter family; Region: EamA; cl01037
447217010990	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
447217010991	EamA-like transporter family; Region: EamA; cl01037
447217010992	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
447217010993	active site
447217010994	intersubunit interactions; other site
447217010995	catalytic residue [active]
447217010996	KpsF/GutQ family protein; Region: kpsF; TIGR00393
447217010997	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
447217010998	putative active site [active]
447217010999	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
447217011000	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
447217011001	intersubunit interface [polypeptide binding]; other site
447217011002	active site
447217011003	Zn2+ binding site [ion binding]; other site
447217011004	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
447217011005	catalytic center binding site [active]
447217011006	ATP binding site [chemical binding]; other site
447217011007	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
447217011008	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
447217011009	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
447217011010	dihydrodipicolinate reductase; Provisional; Region: PRK00048
447217011011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011012	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
447217011013	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
447217011014	dihydrodipicolinate synthase; Region: dapA; TIGR00674
447217011015	dimer interface [polypeptide binding]; other site
447217011016	active site
447217011017	catalytic residue [active]
447217011018	diaminopimelate decarboxylase; Region: lysA; TIGR01048
447217011019	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
447217011020	active site
447217011021	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
447217011022	substrate binding site [chemical binding]; other site
447217011023	catalytic residues [active]
447217011024	dimer interface [polypeptide binding]; other site
447217011025	argininosuccinate lyase; Provisional; Region: PRK00855
447217011026	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
447217011027	active sites [active]
447217011028	tetramer interface [polypeptide binding]; other site
447217011029	OsmC-like protein; Region: OsmC; cl00767
447217011030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
447217011031	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
447217011032	dimer interface [polypeptide binding]; other site
447217011033	substrate binding site [chemical binding]; other site
447217011034	metal binding site [ion binding]; metal-binding site
447217011035	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
447217011036	Nucleoside recognition; Region: Gate; cl00486
447217011037	Nucleoside recognition; Region: Gate; cl00486
447217011038	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
447217011039	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011040	active site
447217011041	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011042	active site
447217011043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011044	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217011045	HSP70 interaction site [polypeptide binding]; other site
447217011046	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
447217011047	4Fe-4S binding domain; Region: Fer4; cl02805
447217011048	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
447217011049	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
447217011050	NAD(P) binding site [chemical binding]; other site
447217011051	Rib/alpha-like repeat; Region: Rib; cl07159
447217011052	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
447217011053	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011054	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
447217011055	active site
447217011056	OPT oligopeptide transporter protein; Region: OPT; cl14607
447217011057	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
447217011058	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011059	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
447217011060	Catalytic domain of Protein Kinases; Region: PKc; cd00180
447217011061	active site
447217011062	ATP binding site [chemical binding]; other site
447217011063	substrate binding site [chemical binding]; other site
447217011064	activation loop (A-loop); other site
447217011065	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
447217011066	interface (dimer of trimers) [polypeptide binding]; other site
447217011067	Substrate-binding/catalytic site; other site
447217011068	Zn-binding sites [ion binding]; other site
447217011069	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
447217011070	dimer interface [polypeptide binding]; other site
447217011071	substrate binding site [chemical binding]; other site
447217011072	metal binding sites [ion binding]; metal-binding site
447217011073	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
447217011074	octamerization interface [polypeptide binding]; other site
447217011075	diferric-oxygen binding site [ion binding]; other site
447217011076	Arginase family; Region: Arginase; cl00306
447217011077	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
447217011078	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
447217011079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217011080	homodimer interface [polypeptide binding]; other site
447217011081	catalytic residue [active]
447217011082	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
447217011083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
447217011084	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
447217011085	classical (c) SDRs; Region: SDR_c; cd05233
447217011086	NAD(P) binding site [chemical binding]; other site
447217011087	active site
447217011088	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
447217011089	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
447217011090	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217011091	Outer membrane efflux protein; Region: OEP; pfam02321
447217011092	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
447217011093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217011094	Helix-turn-helix domains; Region: HTH; cl00088
447217011095	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
447217011096	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
447217011097	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011098	active site
447217011099	Dehydratase family; Region: ILVD_EDD; cl00340
447217011100	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
447217011101	putative active site [active]
447217011102	putative CoA binding site [chemical binding]; other site
447217011103	nudix motif; other site
447217011104	metal binding site [ion binding]; metal-binding site
447217011105	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
447217011106	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217011107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011108	active site
447217011109	phosphorylation site [posttranslational modification]
447217011110	intermolecular recognition site; other site
447217011111	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
447217011112	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
447217011113	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
447217011114	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
447217011115	active site
447217011116	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
447217011117	lipoyl attachment site [posttranslational modification]; other site
447217011118	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011120	active site
447217011121	phosphorylation site [posttranslational modification]
447217011122	intermolecular recognition site; other site
447217011123	dimerization interface [polypeptide binding]; other site
447217011124	PAS fold; Region: PAS; pfam00989
447217011125	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
447217011126	putative active site [active]
447217011127	heme pocket [chemical binding]; other site
447217011128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
447217011129	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
447217011130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011131	ATP binding site [chemical binding]; other site
447217011132	Mg2+ binding site [ion binding]; other site
447217011133	G-X-G motif; other site
447217011134	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011135	dimerization interface [polypeptide binding]; other site
447217011136	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011137	dimerization interface [polypeptide binding]; other site
447217011138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011141	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011142	dimerization interface [polypeptide binding]; other site
447217011143	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011144	dimerization interface [polypeptide binding]; other site
447217011145	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011148	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011149	GAF domain; Region: GAF_2; pfam13185
447217011150	GAF domain; Region: GAF; cl15785
447217011151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011152	dimer interface [polypeptide binding]; other site
447217011153	phosphorylation site [posttranslational modification]
447217011154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011155	ATP binding site [chemical binding]; other site
447217011156	Mg2+ binding site [ion binding]; other site
447217011157	G-X-G motif; other site
447217011158	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011160	active site
447217011161	phosphorylation site [posttranslational modification]
447217011162	intermolecular recognition site; other site
447217011163	dimerization interface [polypeptide binding]; other site
447217011164	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
447217011165	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
447217011166	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
447217011167	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
447217011168	Ca binding site [ion binding]; other site
447217011169	active site
447217011170	catalytic site [active]
447217011171	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
447217011172	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
447217011173	carbohydrate binding site [chemical binding]; other site
447217011174	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
447217011175	trimer interface; other site
447217011176	sugar binding site [chemical binding]; other site
447217011177	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
447217011178	putative ligand binding site [chemical binding]; other site
447217011179	ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833
447217011180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011181	dimer interface [polypeptide binding]; other site
447217011182	conserved gate region; other site
447217011183	putative PBP binding loops; other site
447217011184	ABC-ATPase subunit interface; other site
447217011185	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
447217011186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
447217011187	dimer interface [polypeptide binding]; other site
447217011188	conserved gate region; other site
447217011189	putative PBP binding loops; other site
447217011190	ABC-ATPase subunit interface; other site
447217011191	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
447217011192	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
447217011193	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
447217011194	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
447217011195	Walker A/P-loop; other site
447217011196	ATP binding site [chemical binding]; other site
447217011197	Q-loop/lid; other site
447217011198	ABC transporter signature motif; other site
447217011199	Walker B; other site
447217011200	D-loop; other site
447217011201	H-loop/switch region; other site
447217011202	TOBE domain; Region: TOBE_2; cl01440
447217011203	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
447217011204	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
447217011205	active site
447217011206	catalytic site [active]
447217011207	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
447217011208	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
447217011209	Uncharacterized conserved protein [Function unknown]; Region: COG3461
447217011210	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
447217011211	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011213	active site
447217011214	phosphorylation site [posttranslational modification]
447217011215	intermolecular recognition site; other site
447217011216	dimerization interface [polypeptide binding]; other site
447217011217	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
447217011218	Predicted exporter [General function prediction only]; Region: COG4258
447217011219	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
447217011220	active site
447217011221	metal binding site [ion binding]; metal-binding site
447217011222	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
447217011223	putative acyl-acceptor binding pocket; other site
447217011224	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217011225	putative acyl-acceptor binding pocket; other site
447217011226	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
447217011227	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
447217011228	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
447217011229	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
447217011230	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
447217011231	DoxX; Region: DoxX; cl00976
447217011232	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
447217011233	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
447217011234	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217011235	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
447217011236	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
447217011237	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
447217011238	Walker A/P-loop; other site
447217011239	ATP binding site [chemical binding]; other site
447217011240	Q-loop/lid; other site
447217011241	ABC transporter signature motif; other site
447217011242	Walker B; other site
447217011243	D-loop; other site
447217011244	H-loop/switch region; other site
447217011245	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217011246	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217011247	FtsX-like permease family; Region: FtsX; cl15850
447217011248	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
447217011249	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
447217011250	FtsX-like permease family; Region: FtsX; cl15850
447217011251	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
447217011252	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217011253	Catalytic site [active]
447217011254	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
447217011255	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
447217011256	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
447217011257	active site
447217011258	DNA binding site [nucleotide binding]
447217011259	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
447217011260	DNA binding site [nucleotide binding]
447217011261	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
447217011262	nickel binding site [ion binding]; other site
447217011263	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
447217011264	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
447217011265	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
447217011266	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
447217011267	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
447217011268	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
447217011269	4Fe-4S binding domain; Region: Fer4; cl02805
447217011270	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
447217011271	CPxP  motif; other site
447217011272	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
447217011273	active site
447217011274	phosphorylation site [posttranslational modification]
447217011275	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
447217011276	30S subunit binding site; other site
447217011277	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
447217011278	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
447217011279	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
447217011280	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
447217011281	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
447217011282	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
447217011283	Walker A/P-loop; other site
447217011284	ATP binding site [chemical binding]; other site
447217011285	Q-loop/lid; other site
447217011286	ABC transporter signature motif; other site
447217011287	Walker B; other site
447217011288	D-loop; other site
447217011289	H-loop/switch region; other site
447217011290	OstA-like protein; Region: OstA; cl00844
447217011291	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
447217011292	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
447217011293	putative acyl-acceptor binding pocket; other site
447217011294	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
447217011295	NeuB family; Region: NeuB; cl00496
447217011296	CTP synthetase; Validated; Region: pyrG; PRK05380
447217011297	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
447217011298	Catalytic site [active]
447217011299	active site
447217011300	UTP binding site [chemical binding]; other site
447217011301	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
447217011302	active site
447217011303	putative oxyanion hole; other site
447217011304	catalytic triad [active]
447217011305	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
447217011306	Ligand binding site; other site
447217011307	oligomer interface; other site
447217011308	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
447217011309	active site
447217011310	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
447217011311	homodimer interface [polypeptide binding]; other site
447217011312	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
447217011313	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
447217011314	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
447217011315	active site
447217011316	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
447217011317	GTPase CgtA; Reviewed; Region: obgE; PRK12299
447217011318	GTP1/OBG; Region: GTP1_OBG; pfam01018
447217011319	Obg GTPase; Region: Obg; cd01898
447217011320	G1 box; other site
447217011321	GTP/Mg2+ binding site [chemical binding]; other site
447217011322	Switch I region; other site
447217011323	G2 box; other site
447217011324	G3 box; other site
447217011325	Switch II region; other site
447217011326	G4 box; other site
447217011327	G5 box; other site
447217011328	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
447217011329	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
447217011330	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
447217011331	Ion channel; Region: Ion_trans_2; cl11596
447217011332	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
447217011333	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
447217011334	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
447217011335	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
447217011336	GatB domain; Region: GatB_Yqey; cl11497
447217011337	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
447217011338	Amidase; Region: Amidase; cl11426
447217011339	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
447217011340	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
447217011341	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
447217011342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217011343	TPR motif; other site
447217011344	TPR repeat; Region: TPR_11; pfam13414
447217011345	binding surface
447217011346	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
447217011347	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011348	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
447217011349	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011350	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
447217011351	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
447217011352	ligand binding site [chemical binding]; other site
447217011353	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
447217011354	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
447217011355	Yip1 domain; Region: Yip1; cl12048
447217011356	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
447217011357	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
447217011358	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
447217011359	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
447217011360	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
447217011361	SLBB domain; Region: SLBB; pfam10531
447217011362	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
447217011363	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
447217011364	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
447217011365	putative dimer interface [polypeptide binding]; other site
447217011366	[2Fe-2S] cluster binding site [ion binding]; other site
447217011367	PilZ domain; Region: PilZ; cl01260
447217011368	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011370	active site
447217011371	phosphorylation site [posttranslational modification]
447217011372	intermolecular recognition site; other site
447217011373	dimerization interface [polypeptide binding]; other site
447217011374	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217011375	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
447217011376	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
447217011377	IHF - DNA interface [nucleotide binding]; other site
447217011378	IHF dimer interface [polypeptide binding]; other site
447217011379	PilZ domain; Region: PilZ; cl01260
447217011380	amidophosphoribosyltransferase; Provisional; Region: PRK09123
447217011381	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
447217011382	active site
447217011383	tetramer interface [polypeptide binding]; other site
447217011384	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
447217011385	active site
447217011386	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
447217011387	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
447217011388	active site
447217011389	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
447217011390	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
447217011391	PilZ domain; Region: PilZ; cl01260
447217011392	PilZ domain; Region: PilZ; cl01260
447217011393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011394	active site
447217011395	phosphorylation site [posttranslational modification]
447217011396	intermolecular recognition site; other site
447217011397	dimerization interface [polypeptide binding]; other site
447217011398	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
447217011399	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
447217011400	dimerization interface [polypeptide binding]; other site
447217011401	ATP binding site [chemical binding]; other site
447217011402	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
447217011403	dimerization interface [polypeptide binding]; other site
447217011404	ATP binding site [chemical binding]; other site
447217011405	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
447217011406	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
447217011407	DNA helicase, putative; Region: TIGR00376
447217011408	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011410	Family description; Region: UvrD_C_2; cl15862
447217011411	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
447217011412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011413	dimer interface [polypeptide binding]; other site
447217011414	phosphorylation site [posttranslational modification]
447217011415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011416	ATP binding site [chemical binding]; other site
447217011417	Mg2+ binding site [ion binding]; other site
447217011418	G-X-G motif; other site
447217011419	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011421	active site
447217011422	phosphorylation site [posttranslational modification]
447217011423	intermolecular recognition site; other site
447217011424	dimerization interface [polypeptide binding]; other site
447217011425	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
447217011426	active site
447217011427	Smr domain; Region: Smr; cl02619
447217011428	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
447217011429	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
447217011430	30S subunit binding site; other site
447217011431	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011433	active site
447217011434	phosphorylation site [posttranslational modification]
447217011435	intermolecular recognition site; other site
447217011436	dimerization interface [polypeptide binding]; other site
447217011437	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217011438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011439	dimer interface [polypeptide binding]; other site
447217011440	phosphorylation site [posttranslational modification]
447217011441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011442	ATP binding site [chemical binding]; other site
447217011443	G-X-G motif; other site
447217011444	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011446	active site
447217011447	phosphorylation site [posttranslational modification]
447217011448	intermolecular recognition site; other site
447217011449	dimerization interface [polypeptide binding]; other site
447217011450	sensor protein ZraS; Provisional; Region: PRK10364
447217011451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011452	ATP binding site [chemical binding]; other site
447217011453	Mg2+ binding site [ion binding]; other site
447217011454	G-X-G motif; other site
447217011455	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011456	dimerization interface [polypeptide binding]; other site
447217011457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011458	phosphorylation site [posttranslational modification]
447217011459	dimer interface [polypeptide binding]; other site
447217011460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011461	ATP binding site [chemical binding]; other site
447217011462	Mg2+ binding site [ion binding]; other site
447217011463	G-X-G motif; other site
447217011464	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
447217011465	Phosphate transporter family; Region: PHO4; cl00396
447217011466	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
447217011467	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
447217011468	FeS/SAM binding site; other site
447217011469	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
447217011470	active site
447217011471	DNA binding site [nucleotide binding]
447217011472	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
447217011473	pyruvate kinase; Provisional; Region: PRK05826
447217011474	domain interfaces; other site
447217011475	active site
447217011476	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
447217011477	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
447217011478	active site
447217011479	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
447217011480	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
447217011481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
447217011482	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217011483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011484	active site
447217011485	phosphorylation site [posttranslational modification]
447217011486	intermolecular recognition site; other site
447217011487	dimerization interface [polypeptide binding]; other site
447217011488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217011489	Walker A motif; other site
447217011490	ATP binding site [chemical binding]; other site
447217011491	Walker B motif; other site
447217011492	arginine finger; other site
447217011493	Helix-turn-helix domains; Region: HTH; cl00088
447217011494	FtsH Extracellular; Region: FtsH_ext; pfam06480
447217011495	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
447217011496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217011497	Walker A motif; other site
447217011498	ATP binding site [chemical binding]; other site
447217011499	Walker B motif; other site
447217011500	arginine finger; other site
447217011501	Peptidase family M41; Region: Peptidase_M41; pfam01434
447217011502	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
447217011503	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
447217011504	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
447217011505	putative active site [active]
447217011506	catalytic site [active]
447217011507	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
447217011508	putative active site [active]
447217011509	catalytic site [active]
447217011510	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
447217011511	GDYXXLXY protein; Region: GDYXXLXY; cl02066
447217011512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
447217011513	dimerization interface [polypeptide binding]; other site
447217011514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011515	dimer interface [polypeptide binding]; other site
447217011516	phosphorylation site [posttranslational modification]
447217011517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011518	ATP binding site [chemical binding]; other site
447217011519	Mg2+ binding site [ion binding]; other site
447217011520	G-X-G motif; other site
447217011521	triacylglycerol lipase; Region: PLN02872
447217011522	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
447217011523	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217011524	Nitrogen regulatory protein P-II; Region: P-II; cl00412
447217011525	Nitrogen regulatory protein P-II; Region: P-II; smart00938
447217011526	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
447217011527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011528	dimer interface [polypeptide binding]; other site
447217011529	phosphorylation site [posttranslational modification]
447217011530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011531	ATP binding site [chemical binding]; other site
447217011532	Mg2+ binding site [ion binding]; other site
447217011533	G-X-G motif; other site
447217011534	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
447217011535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011536	active site
447217011537	phosphorylation site [posttranslational modification]
447217011538	intermolecular recognition site; other site
447217011539	dimerization interface [polypeptide binding]; other site
447217011540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217011541	Walker A motif; other site
447217011542	ATP binding site [chemical binding]; other site
447217011543	Walker B motif; other site
447217011544	arginine finger; other site
447217011545	Helix-turn-helix domains; Region: HTH; cl00088
447217011546	glutamine synthetase, type I; Region: GlnA; TIGR00653
447217011547	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
447217011548	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
447217011549	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
447217011550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
447217011551	Major Facilitator Superfamily; Region: MFS_1; pfam07690
447217011552	putative substrate translocation pore; other site
447217011553	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
447217011554	Transposase domain (DUF772); Region: DUF772; cl15789
447217011555	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
447217011556	Transposase domain (DUF772); Region: DUF772; cl15789
447217011557	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
447217011558	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
447217011559	Walker A/P-loop; other site
447217011560	ATP binding site [chemical binding]; other site
447217011561	Q-loop/lid; other site
447217011562	ABC transporter signature motif; other site
447217011563	Walker B; other site
447217011564	D-loop; other site
447217011565	H-loop/switch region; other site
447217011566	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
447217011567	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
447217011568	Walker A/P-loop; other site
447217011569	ATP binding site [chemical binding]; other site
447217011570	Q-loop/lid; other site
447217011571	ABC transporter signature motif; other site
447217011572	Walker B; other site
447217011573	D-loop; other site
447217011574	H-loop/switch region; other site
447217011575	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
447217011576	TM-ABC transporter signature motif; other site
447217011577	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
447217011578	TM-ABC transporter signature motif; other site
447217011579	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
447217011580	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
447217011581	putative ligand binding site [chemical binding]; other site
447217011582	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011584	active site
447217011585	phosphorylation site [posttranslational modification]
447217011586	intermolecular recognition site; other site
447217011587	dimerization interface [polypeptide binding]; other site
447217011588	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
447217011589	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
447217011590	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
447217011591	Aerotolerance regulator N-terminal; Region: BatA; cl06567
447217011592	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
447217011593	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
447217011594	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
447217011595	MoxR-like ATPases [General function prediction only]; Region: COG0714
447217011596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
447217011597	Walker A motif; other site
447217011598	ATP binding site [chemical binding]; other site
447217011599	Walker B motif; other site
447217011600	arginine finger; other site
447217011601	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
447217011602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
447217011603	TPR motif; other site
447217011604	binding surface
447217011605	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
447217011606	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
447217011607	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
447217011608	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
447217011609	DNA binding residues [nucleotide binding]
447217011610	tyrosine kinase; Provisional; Region: PRK11519
447217011611	Chain length determinant protein; Region: Wzz; cl15801
447217011612	Chain length determinant protein; Region: Wzz; cl15801
447217011613	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
447217011614	P loop; other site
447217011615	Nucleotide binding site [chemical binding]; other site
447217011616	DTAP/Switch II; other site
447217011617	Switch I; other site
447217011618	polysaccharide export protein Wza; Provisional; Region: PRK15078
447217011619	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
447217011620	Low molecular weight phosphatase family; Region: LMWPc; cd00115
447217011621	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
447217011622	active site
447217011623	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
447217011624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011625	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
447217011626	NAD(P) binding site [chemical binding]; other site
447217011627	homodimer interface [polypeptide binding]; other site
447217011628	substrate binding site [chemical binding]; other site
447217011629	active site
447217011630	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
447217011631	putative trimer interface [polypeptide binding]; other site
447217011632	putative CoA binding site [chemical binding]; other site
447217011633	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
447217011634	putative ADP-binding pocket [chemical binding]; other site
447217011635	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
447217011636	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011637	NAD(P) binding site [chemical binding]; other site
447217011638	active site
447217011639	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
447217011640	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
447217011641	Mg++ binding site [ion binding]; other site
447217011642	putative catalytic motif [active]
447217011643	putative substrate binding site [chemical binding]; other site
447217011644	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
447217011645	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217011646	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217011647	MatE; Region: MatE; cl10513
447217011648	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
447217011649	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217011650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011651	NAD(P) binding site [chemical binding]; other site
447217011652	active site
447217011653	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217011654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011655	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
447217011656	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
447217011657	NAD binding site [chemical binding]; other site
447217011658	substrate binding site [chemical binding]; other site
447217011659	homodimer interface [polypeptide binding]; other site
447217011660	active site
447217011661	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
447217011662	putative ADP-binding pocket [chemical binding]; other site
447217011663	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
447217011664	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
447217011665	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
447217011666	NADP binding site [chemical binding]; other site
447217011667	active site
447217011668	putative substrate binding site [chemical binding]; other site
447217011669	GDP-mannose 4,6-dehydratase; Region: PLN02653
447217011670	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
447217011671	NADP-binding site; other site
447217011672	homotetramer interface [polypeptide binding]; other site
447217011673	substrate binding site [chemical binding]; other site
447217011674	homodimer interface [polypeptide binding]; other site
447217011675	active site
447217011676	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
447217011677	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
447217011678	NAD binding site [chemical binding]; other site
447217011679	substrate binding site [chemical binding]; other site
447217011680	homodimer interface [polypeptide binding]; other site
447217011681	active site
447217011682	Cupin domain; Region: Cupin_2; cl09118
447217011683	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
447217011684	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
447217011685	substrate binding site; other site
447217011686	tetramer interface; other site
447217011687	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
447217011688	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
447217011689	NADP binding site [chemical binding]; other site
447217011690	active site
447217011691	putative substrate binding site [chemical binding]; other site
447217011692	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
447217011693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011694	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217011695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011696	Domain of unknown function (DUF222); Region: DUF222; pfam02720
447217011697	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
447217011698	active site
447217011699	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
447217011700	Ligand binding site; other site
447217011701	Putative Catalytic site; other site
447217011702	DXD motif; other site
447217011703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011704	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
447217011705	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
447217011706	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
447217011707	metal-binding site
447217011708	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
447217011709	active site
447217011710	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
447217011711	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
447217011712	active site
447217011713	homodimer interface [polypeptide binding]; other site
447217011714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011715	TIGR01777 family protein; Region: yfcH
447217011716	NAD(P) binding site [chemical binding]; other site
447217011717	active site
447217011718	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
447217011719	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
447217011720	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
447217011721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
447217011722	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
447217011723	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
447217011724	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
447217011725	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217011726	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
447217011727	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
447217011728	PAS domain; Region: PAS_9; pfam13426
447217011729	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
447217011730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011731	dimer interface [polypeptide binding]; other site
447217011732	phosphorylation site [posttranslational modification]
447217011733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011734	ATP binding site [chemical binding]; other site
447217011735	Mg2+ binding site [ion binding]; other site
447217011736	G-X-G motif; other site
447217011737	Protein of unknown function DUF111; Region: DUF111; cl03398
447217011738	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
447217011739	AIR carboxylase; Region: AIRC; cl00310
447217011740	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
447217011741	Chemotaxis phosphatase CheX; Region: CheX; cl15816
447217011742	Chemotaxis phosphatase CheX; Region: CheX; cl15816
447217011743	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
447217011744	putative binding surface; other site
447217011745	active site
447217011746	P2 response regulator binding domain; Region: P2; pfam07194
447217011747	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
447217011748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011749	ATP binding site [chemical binding]; other site
447217011750	Mg2+ binding site [ion binding]; other site
447217011751	G-X-G motif; other site
447217011752	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217011753	Response regulator receiver domain; Region: Response_reg; pfam00072
447217011754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
447217011755	active site
447217011756	phosphorylation site [posttranslational modification]
447217011757	intermolecular recognition site; other site
447217011758	dimerization interface [polypeptide binding]; other site
447217011759	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
447217011760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
447217011761	dimerization interface [polypeptide binding]; other site
447217011762	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
447217011763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
447217011764	dimer interface [polypeptide binding]; other site
447217011765	putative CheW interface [polypeptide binding]; other site
447217011766	thiamine monophosphate kinase; Provisional; Region: PRK05731
447217011767	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
447217011768	ATP binding site [chemical binding]; other site
447217011769	dimerization interface [polypeptide binding]; other site
447217011770	Sensory domain found in PocR; Region: PocR; pfam10114
447217011771	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
447217011772	dimer interface [polypeptide binding]; other site
447217011773	phosphorylation site [posttranslational modification]
447217011774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
447217011775	ATP binding site [chemical binding]; other site
447217011776	Mg2+ binding site [ion binding]; other site
447217011777	G-X-G motif; other site
447217011778	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
447217011779	G1 box; other site
447217011780	GTP/Mg2+ binding site [chemical binding]; other site
447217011781	G2 box; other site
447217011782	Switch I region; other site
447217011783	G3 box; other site
447217011784	Switch II region; other site
447217011785	G4 box; other site
447217011786	G5 box; other site
447217011787	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
447217011788	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011789	DEAD_2; Region: DEAD_2; pfam06733
447217011790	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011791	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
447217011792	active site
447217011793	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
447217011794	putative substrate binding region [chemical binding]; other site
447217011795	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
447217011796	putative ligand binding site [chemical binding]; other site
447217011797	chaperone protein DnaJ; Provisional; Region: PRK10767
447217011798	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
447217011799	HSP70 interaction site [polypeptide binding]; other site
447217011800	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
447217011801	Zn binding sites [ion binding]; other site
447217011802	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
447217011803	dimer interface [polypeptide binding]; other site
447217011804	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
447217011805	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
447217011806	HrcA protein C terminal domain; Region: HrcA; pfam01628
447217011807	Tetratricopeptide repeat; Region: TPR_12; pfam13424
447217011808	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
447217011809	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
447217011810	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
447217011811	DEAD-like helicases superfamily; Region: DEXDc; smart00487
447217011812	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011813	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
447217011814	nucleotide binding region [chemical binding]; other site
447217011815	ATP-binding site [chemical binding]; other site
447217011816	TRCF domain; Region: TRCF; cl04088
447217011817	SurA N-terminal domain; Region: SurA_N_3; cl07813
447217011818	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
447217011819	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217011820	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217011821	SurA N-terminal domain; Region: SurA_N_3; cl07813
447217011822	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
447217011823	PPIC-type PPIASE domain; Region: Rotamase; cl08278
447217011824	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
447217011825	GTP-binding protein YchF; Reviewed; Region: PRK09601
447217011826	YchF GTPase; Region: YchF; cd01900
447217011827	G1 box; other site
447217011828	GTP/Mg2+ binding site [chemical binding]; other site
447217011829	Switch I region; other site
447217011830	G2 box; other site
447217011831	Switch II region; other site
447217011832	G3 box; other site
447217011833	G4 box; other site
447217011834	G5 box; other site
447217011835	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
447217011836	Plant ATP synthase F0; Region: YMF19; cl07975
447217011837	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
447217011838	ATP synthase subunit C; Region: ATP-synt_C; cl00466
447217011839	ATP synthase A chain; Region: ATP-synt_A; cl00413
447217011840	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
447217011841	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
447217011842	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
447217011843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
447217011844	catalytic residue [active]
447217011845	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
447217011846	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
447217011847	inhibitor-cofactor binding pocket; inhibition site
447217011848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
447217011849	catalytic residue [active]
447217011850	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
447217011851	DNA gyrase subunit A; Validated; Region: PRK05560
447217011852	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
447217011853	CAP-like domain; other site
447217011854	active site
447217011855	primary dimer interface [polypeptide binding]; other site
447217011856	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217011857	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217011858	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217011859	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217011860	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
447217011861	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
447217011862	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
447217011863	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
447217011864	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
447217011865	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
447217011866	alpha subunit interaction interface [polypeptide binding]; other site
447217011867	Walker A motif; other site
447217011868	ATP binding site [chemical binding]; other site
447217011869	Walker B motif; other site
447217011870	inhibitor binding site; inhibition site
447217011871	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217011872	ATP synthase; Region: ATP-synt; cl00365
447217011873	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
447217011874	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
447217011875	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
447217011876	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
447217011877	beta subunit interaction interface [polypeptide binding]; other site
447217011878	Walker A motif; other site
447217011879	ATP binding site [chemical binding]; other site
447217011880	Walker B motif; other site
447217011881	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
447217011882	Plant ATP synthase F0; Region: YMF19; cl07975
447217011883	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
447217011884	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
447217011885	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
447217011886	putative dimer interface [polypeptide binding]; other site
447217011887	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
447217011888	ParB-like partition proteins; Region: parB_part; TIGR00180
447217011889	ParB-like nuclease domain; Region: ParBc; cl02129
447217011890	KorB domain; Region: KorB; pfam08535
447217011891	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
447217011892	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
447217011893	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
447217011894	Magnesium ion binding site [ion binding]; other site
447217011895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
447217011896	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
447217011897	G-X-X-G motif; other site
447217011898	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
447217011899	RxxxH motif; other site
447217011900	membrane protein insertase; Provisional; Region: PRK01318
447217011901	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
447217011902	Haemolytic domain; Region: Haemolytic; cl00506
447217011903	Ribonuclease P; Region: Ribonuclease_P; cl00457
447217011904	Ribosomal protein L34; Region: Ribosomal_L34; cl00370