-- dump date 20120504_133333 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290340000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 290340000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000003 Walker A motif; other site 290340000004 ATP binding site [chemical binding]; other site 290340000005 Walker B motif; other site 290340000006 arginine finger; other site 290340000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290340000008 DnaA box-binding interface [nucleotide binding]; other site 290340000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 290340000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290340000011 putative DNA binding surface [nucleotide binding]; other site 290340000012 dimer interface [polypeptide binding]; other site 290340000013 beta-clamp/clamp loader binding surface; other site 290340000014 beta-clamp/translesion DNA polymerase binding surface; other site 290340000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 290340000017 recombination protein F; Reviewed; Region: recF; PRK00064 290340000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 290340000019 Walker A/P-loop; other site 290340000020 ATP binding site [chemical binding]; other site 290340000021 Q-loop/lid; other site 290340000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340000023 ABC transporter signature motif; other site 290340000024 Walker B; other site 290340000025 D-loop; other site 290340000026 H-loop/switch region; other site 290340000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 290340000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 290340000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290340000030 anchoring element; other site 290340000031 dimer interface [polypeptide binding]; other site 290340000032 ATP binding site [chemical binding]; other site 290340000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290340000034 active site 290340000035 putative metal-binding site [ion binding]; other site 290340000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290340000037 DNA gyrase subunit A; Validated; Region: PRK05560 290340000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 290340000039 CAP-like domain; other site 290340000040 active site 290340000041 primary dimer interface [polypeptide binding]; other site 290340000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 290340000049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340000050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340000051 active site 290340000052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340000053 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 290340000054 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 290340000055 active site 290340000056 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 290340000057 Rhomboid family; Region: Rhomboid; cl11446 290340000058 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 290340000059 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 290340000060 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 290340000061 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290340000062 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340000063 DNA binding site [nucleotide binding] 290340000064 active site 290340000065 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340000068 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 290340000069 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340000070 DNA binding site [nucleotide binding] 290340000071 active site 290340000072 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 290340000073 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 290340000074 active site 290340000075 catalytic site [active] 290340000076 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290340000077 Glutamine amidotransferase class-I; Region: GATase; pfam00117 290340000078 glutamine binding [chemical binding]; other site 290340000079 catalytic triad [active] 290340000080 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340000081 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340000082 active site 290340000083 ATP binding site [chemical binding]; other site 290340000084 substrate binding site [chemical binding]; other site 290340000085 activation loop (A-loop); other site 290340000086 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000087 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340000089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340000090 active site 290340000091 ATP binding site [chemical binding]; other site 290340000092 substrate binding site [chemical binding]; other site 290340000093 activation loop (A-loop); other site 290340000094 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 290340000095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000096 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340000097 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 290340000098 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290340000099 active site 290340000100 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340000101 phosphopeptide binding site; other site 290340000102 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 290340000103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340000104 phosphopeptide binding site; other site 290340000105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340000106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000107 DNA-binding site [nucleotide binding]; DNA binding site 290340000108 FCD domain; Region: FCD; cl11656 290340000109 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340000110 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340000111 active site pocket [active] 290340000112 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cl00039 290340000113 mannose binding site [chemical binding]; other site 290340000114 dimerization interface [polypeptide binding]; other site 290340000115 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 290340000116 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290340000117 Helix-turn-helix domains; Region: HTH; cl00088 290340000118 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290340000119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000120 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290340000121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340000122 Ligand Binding Site [chemical binding]; other site 290340000123 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290340000124 Spore germination protein; Region: Spore_permease; cl15802 290340000125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000126 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340000127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340000128 dimerization interface [polypeptide binding]; other site 290340000129 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 290340000130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000131 DNA-binding site [nucleotide binding]; DNA binding site 290340000132 FCD domain; Region: FCD; cl11656 290340000133 LamB/YcsF family; Region: LamB_YcsF; cl00664 290340000134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000135 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340000136 putative substrate translocation pore; other site 290340000137 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290340000138 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290340000139 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 290340000140 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290340000141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340000142 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340000143 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340000144 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340000145 carboxyltransferase (CT) interaction site; other site 290340000146 biotinylation site [posttranslational modification]; other site 290340000147 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 290340000148 FAD binding domain; Region: FAD_binding_4; pfam01565 290340000149 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 290340000150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000152 DNA binding site [nucleotide binding] 290340000153 domain linker motif; other site 290340000154 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000155 dimerization interface [polypeptide binding]; other site 290340000156 ligand binding site [chemical binding]; other site 290340000157 Membrane transport protein; Region: Mem_trans; cl09117 290340000158 bile acid transporter; Region: bass; TIGR00841 290340000159 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290340000160 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340000161 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340000162 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290340000163 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290340000164 synthetase active site [active] 290340000165 NTP binding site [chemical binding]; other site 290340000166 metal binding site [ion binding]; metal-binding site 290340000167 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340000168 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340000169 putative substrate binding site [chemical binding]; other site 290340000170 putative ATP binding site [chemical binding]; other site 290340000171 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 290340000172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340000173 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 290340000174 putative dimer interface [polypeptide binding]; other site 290340000175 N-terminal domain interface [polypeptide binding]; other site 290340000176 putative substrate binding pocket (H-site) [chemical binding]; other site 290340000177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000178 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290340000179 active site 290340000180 motif I; other site 290340000181 motif II; other site 290340000182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000183 Phospholipid methyltransferase; Region: PEMT; cl00763 290340000184 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340000185 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290340000186 putative NAD(P) binding site [chemical binding]; other site 290340000187 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 290340000188 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 290340000189 putative active site [active] 290340000190 catalytic site [active] 290340000191 putative metal binding site [ion binding]; other site 290340000192 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 290340000193 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290340000194 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 290340000195 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290340000196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000197 Glycerate kinase family; Region: Gly_kinase; cl00841 290340000198 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 290340000199 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 290340000200 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340000201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340000203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340000205 putative substrate translocation pore; other site 290340000206 Helix-turn-helix domains; Region: HTH; cl00088 290340000207 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340000208 Family description; Region: VCBS; pfam13517 290340000209 Family description; Region: VCBS; pfam13517 290340000210 Family description; Region: VCBS; pfam13517 290340000211 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 290340000212 intracellular protease, PfpI family; Region: PfpI; TIGR01382 290340000213 proposed catalytic triad [active] 290340000214 conserved cys residue [active] 290340000215 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340000216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000219 DNA binding site [nucleotide binding] 290340000220 domain linker motif; other site 290340000221 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 290340000222 putative dimerization interface [polypeptide binding]; other site 290340000223 putative ligand binding site [chemical binding]; other site 290340000224 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290340000225 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340000226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000227 dimer interface [polypeptide binding]; other site 290340000228 conserved gate region; other site 290340000229 putative PBP binding loops; other site 290340000230 ABC-ATPase subunit interface; other site 290340000231 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 290340000232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000233 dimer interface [polypeptide binding]; other site 290340000234 conserved gate region; other site 290340000235 ABC-ATPase subunit interface; other site 290340000236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340000237 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 290340000238 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 290340000239 active site 290340000240 S-layer homology domain; Region: SLH; pfam00395 290340000241 S-layer homology domain; Region: SLH; pfam00395 290340000242 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 290340000243 uracil transporter; Provisional; Region: PRK10720 290340000244 OpgC protein; Region: OpgC_C; cl00792 290340000245 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340000246 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 290340000247 putative FMN binding site [chemical binding]; other site 290340000248 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 290340000249 phosphoglucomutase; Validated; Region: PRK07564 290340000250 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 290340000251 active site 290340000252 substrate binding site [chemical binding]; other site 290340000253 metal binding site [ion binding]; metal-binding site 290340000254 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 290340000255 classical (c) SDRs; Region: SDR_c; cd05233 290340000256 NAD(P) binding site [chemical binding]; other site 290340000257 active site 290340000258 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 290340000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 290340000260 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 290340000261 active site pocket [active] 290340000262 oxyanion hole [active] 290340000263 catalytic triad [active] 290340000264 active site nucleophile [active] 290340000265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340000266 active site residue [active] 290340000267 prephenate dehydratase; Provisional; Region: PRK11898 290340000268 Prephenate dehydratase; Region: PDT; pfam00800 290340000269 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290340000270 putative L-Phe binding site [chemical binding]; other site 290340000271 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340000272 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340000273 seryl-tRNA synthetase; Provisional; Region: PRK05431 290340000274 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290340000275 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 290340000276 dimer interface [polypeptide binding]; other site 290340000277 active site 290340000278 motif 1; other site 290340000279 motif 2; other site 290340000280 motif 3; other site 290340000281 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340000282 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290340000283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000284 active site 290340000285 motif I; other site 290340000286 motif II; other site 290340000287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000288 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340000289 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 290340000290 GAF domain; Region: GAF; cl15785 290340000291 ANTAR domain; Region: ANTAR; cl04297 290340000292 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 290340000293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000294 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290340000295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340000296 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000297 putative active site [active] 290340000298 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 290340000299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000300 active site 290340000301 motif I; other site 290340000302 motif II; other site 290340000303 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340000304 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290340000305 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000306 putative active site [active] 290340000307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340000308 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290340000309 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 290340000310 putative ADP-binding pocket [chemical binding]; other site 290340000311 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290340000312 dimer interface [polypeptide binding]; other site 290340000313 active site 290340000314 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 290340000315 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340000316 substrate binding site [chemical binding]; other site 290340000317 ATP binding site [chemical binding]; other site 290340000318 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340000319 active site 290340000320 HIGH motif; other site 290340000321 nucleotide binding site [chemical binding]; other site 290340000322 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340000323 classical (c) SDRs; Region: SDR_c; cd05233 290340000324 NAD(P) binding site [chemical binding]; other site 290340000325 active site 290340000326 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000327 putative active site [active] 290340000328 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 290340000329 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340000330 substrate binding site [chemical binding]; other site 290340000331 ATP binding site [chemical binding]; other site 290340000332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340000333 active site 290340000334 nucleotide binding site [chemical binding]; other site 290340000335 HIGH motif; other site 290340000336 KMSKS motif; other site 290340000337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340000338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000339 NAD(P) binding site [chemical binding]; other site 290340000340 active site 290340000341 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 290340000342 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 290340000343 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 290340000344 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340000345 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 290340000346 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340000347 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 290340000348 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290340000349 Ligand Binding Site [chemical binding]; other site 290340000350 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 290340000351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340000352 active site 290340000353 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340000354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000355 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340000356 Walker A motif; other site 290340000357 ATP binding site [chemical binding]; other site 290340000358 Walker B motif; other site 290340000359 arginine finger; other site 290340000360 Peptidase family M41; Region: Peptidase_M41; pfam01434 290340000361 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 290340000362 homodecamer interface [polypeptide binding]; other site 290340000363 GTP cyclohydrolase I; Provisional; Region: PLN03044 290340000364 active site 290340000365 putative catalytic site residues [active] 290340000366 zinc binding site [ion binding]; other site 290340000367 GTP-CH-I/GFRP interaction surface; other site 290340000368 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290340000369 dihydropteroate synthase; Region: DHPS; TIGR01496 290340000370 substrate binding pocket [chemical binding]; other site 290340000371 dimer interface [polypeptide binding]; other site 290340000372 inhibitor binding site; inhibition site 290340000373 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290340000374 homooctamer interface [polypeptide binding]; other site 290340000375 active site 290340000376 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290340000377 catalytic center binding site [active] 290340000378 ATP binding site [chemical binding]; other site 290340000379 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 290340000380 Bacterial PH domain; Region: DUF304; cl01348 290340000381 Bacterial PH domain; Region: DUF304; cl01348 290340000382 Bacterial PH domain; Region: DUF304; cl01348 290340000383 Bacterial PH domain; Region: DUF304; cl01348 290340000384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000385 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 290340000386 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290340000387 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290340000388 active site 290340000389 ATP-binding site [chemical binding]; other site 290340000390 pantoate-binding site; other site 290340000391 HXXH motif; other site 290340000392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000393 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340000394 putative substrate translocation pore; other site 290340000395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340000396 Helix-turn-helix domains; Region: HTH; cl00088 290340000397 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 290340000398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340000399 dimerization interface [polypeptide binding]; other site 290340000400 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290340000401 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 290340000402 EamA-like transporter family; Region: EamA; cl01037 290340000403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000405 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000406 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340000407 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290340000408 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290340000409 putative anticodon binding site; other site 290340000410 dimer interface [polypeptide binding]; other site 290340000411 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290340000412 motif 1; other site 290340000413 dimer interface [polypeptide binding]; other site 290340000414 active site 290340000415 motif 2; other site 290340000416 motif 3; other site 290340000417 Lsr2; Region: Lsr2; pfam11774 290340000418 Clp protease ATP binding subunit; Region: clpC; CHL00095 290340000419 Clp amino terminal domain; Region: Clp_N; pfam02861 290340000420 Clp amino terminal domain; Region: Clp_N; pfam02861 290340000421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000422 Walker A motif; other site 290340000423 ATP binding site [chemical binding]; other site 290340000424 Walker B motif; other site 290340000425 arginine finger; other site 290340000426 UvrB/uvrC motif; Region: UVR; pfam02151 290340000427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000428 Walker A motif; other site 290340000429 ATP binding site [chemical binding]; other site 290340000430 Walker B motif; other site 290340000431 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290340000432 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 290340000433 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 290340000434 homodimer interface [polypeptide binding]; other site 290340000435 active site 290340000436 TDP-binding site; other site 290340000437 acceptor substrate-binding pocket; other site 290340000438 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290340000439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340000440 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 290340000441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340000442 Coenzyme A binding pocket [chemical binding]; other site 290340000443 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290340000444 FAD binding domain; Region: FAD_binding_4; pfam01565 290340000445 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290340000446 Dak1 domain; Region: Dak1; pfam02733 290340000447 DAK2 domain; Region: Dak2; cl03685 290340000448 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 290340000449 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340000450 dimerization domain swap beta strand [polypeptide binding]; other site 290340000451 regulatory protein interface [polypeptide binding]; other site 290340000452 active site 290340000453 regulatory phosphorylation site [posttranslational modification]; other site 290340000454 CsbD-like; Region: CsbD; cl15799 290340000455 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 290340000456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000457 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340000458 active site 290340000459 metal binding site [ion binding]; metal-binding site 290340000460 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340000461 putative dimer interface [polypeptide binding]; other site 290340000462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000465 Prophage protein (DUF1660); Region: DUF1660; pfam07874 290340000466 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340000467 endonuclease III; Region: ENDO3c; smart00478 290340000468 minor groove reading motif; other site 290340000469 helix-hairpin-helix signature motif; other site 290340000470 substrate binding pocket [chemical binding]; other site 290340000471 active site 290340000472 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 290340000473 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 290340000474 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 290340000475 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 290340000476 allophanate hydrolase; Provisional; Region: PRK08186 290340000477 Amidase; Region: Amidase; cl11426 290340000478 urea carboxylase; Region: urea_carbox; TIGR02712 290340000479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340000480 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340000481 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340000482 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 290340000483 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290340000484 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340000485 carboxyltransferase (CT) interaction site; other site 290340000486 biotinylation site [posttranslational modification]; other site 290340000487 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290340000488 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 290340000489 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 290340000490 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290340000491 Spore germination protein; Region: Spore_permease; cl15802 290340000492 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 290340000493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340000494 Helix-turn-helix domains; Region: HTH; cl00088 290340000495 DNA repair protein RadA; Provisional; Region: PRK11823 290340000496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340000497 Walker A motif; other site 290340000498 ATP binding site [chemical binding]; other site 290340000499 Walker B motif; other site 290340000500 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 290340000501 Predicted membrane protein [Function unknown]; Region: COG4129 290340000502 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 290340000503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340000504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000505 conserved gate region; other site 290340000506 putative PBP binding loops; other site 290340000507 ABC-ATPase subunit interface; other site 290340000508 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 290340000509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000510 dimer interface [polypeptide binding]; other site 290340000511 conserved gate region; other site 290340000512 putative PBP binding loops; other site 290340000513 ABC-ATPase subunit interface; other site 290340000514 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 290340000515 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 290340000516 Walker A/P-loop; other site 290340000517 ATP binding site [chemical binding]; other site 290340000518 Q-loop/lid; other site 290340000519 ABC transporter signature motif; other site 290340000520 Walker B; other site 290340000521 D-loop; other site 290340000522 H-loop/switch region; other site 290340000523 Phosphate transporter family; Region: PHO4; cl00396 290340000524 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 290340000525 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290340000526 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 290340000527 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 290340000528 GAF domain; Region: GAF; cl15785 290340000529 GAF domain; Region: GAF_2; pfam13185 290340000530 ANTAR domain; Region: ANTAR; cl04297 290340000531 GAF domain; Region: GAF; cl15785 290340000532 GAF domain; Region: GAF_2; pfam13185 290340000533 ANTAR domain; Region: ANTAR; cl04297 290340000534 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290340000535 GAF domain; Region: GAF; cl15785 290340000536 ANTAR domain; Region: ANTAR; cl04297 290340000537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000539 DNA binding site [nucleotide binding] 290340000540 domain linker motif; other site 290340000541 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000542 dimerization interface [polypeptide binding]; other site 290340000543 ligand binding site [chemical binding]; other site 290340000544 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 290340000545 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 290340000546 dimer interface [polypeptide binding]; other site 290340000547 active site 290340000548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340000549 substrate binding site [chemical binding]; other site 290340000550 catalytic residue [active] 290340000551 Flavin Reductases; Region: FlaRed; cl00801 290340000552 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 290340000553 alpha-gamma subunit interface [polypeptide binding]; other site 290340000554 beta-gamma subunit interface [polypeptide binding]; other site 290340000555 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 290340000556 gamma-beta subunit interface [polypeptide binding]; other site 290340000557 alpha-beta subunit interface [polypeptide binding]; other site 290340000558 urease subunit alpha; Reviewed; Region: ureC; PRK13207 290340000559 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 290340000560 subunit interactions [polypeptide binding]; other site 290340000561 active site 290340000562 flap region; other site 290340000563 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 290340000564 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 290340000565 dimer interface [polypeptide binding]; other site 290340000566 catalytic residues [active] 290340000567 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 290340000568 UreF; Region: UreF; pfam01730 290340000569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340000570 UreD urease accessory protein; Region: UreD; cl00530 290340000571 High-affinity nickel-transport protein; Region: NicO; cl00964 290340000572 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340000573 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340000576 DNA binding residues [nucleotide binding] 290340000577 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290340000578 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290340000579 active site 290340000580 catalytic site [active] 290340000581 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 290340000582 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000584 active site 290340000585 catalytic tetrad [active] 290340000586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000587 NAD(P) binding site [chemical binding]; other site 290340000588 active site 290340000589 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340000590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000591 active site 290340000592 catalytic tetrad [active] 290340000593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000595 active site 290340000596 catalytic tetrad [active] 290340000597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340000598 salt bridge; other site 290340000599 non-specific DNA binding site [nucleotide binding]; other site 290340000600 sequence-specific DNA binding site [nucleotide binding]; other site 290340000601 Dodecin; Region: Dodecin; cl01328 290340000602 oxidoreductase; Provisional; Region: PRK12743 290340000603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000604 NAD(P) binding site [chemical binding]; other site 290340000605 active site 290340000606 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340000607 Ligand Binding Site [chemical binding]; other site 290340000608 Pectate lyase; Region: Pec_lyase_C; cl01593 290340000609 Pectinesterase; Region: Pectinesterase; cl01911 290340000610 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 290340000611 Pectate lyase; Region: Pec_lyase_C; cl01593 290340000612 Pectinesterase; Region: Pectinesterase; cl01911 290340000613 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340000614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000615 dimer interface [polypeptide binding]; other site 290340000616 conserved gate region; other site 290340000617 putative PBP binding loops; other site 290340000618 ABC-ATPase subunit interface; other site 290340000619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000621 dimer interface [polypeptide binding]; other site 290340000622 putative PBP binding loops; other site 290340000623 ABC-ATPase subunit interface; other site 290340000624 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340000625 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 290340000626 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 290340000627 active site 290340000628 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000630 DNA binding site [nucleotide binding] 290340000631 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340000632 putative dimerization interface [polypeptide binding]; other site 290340000633 putative ligand binding site [chemical binding]; other site 290340000634 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340000635 PYR/PP interface [polypeptide binding]; other site 290340000636 dimer interface [polypeptide binding]; other site 290340000637 TPP binding site [chemical binding]; other site 290340000638 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290340000639 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340000640 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340000641 TPP-binding site [chemical binding]; other site 290340000642 Putative cyclase; Region: Cyclase; cl00814 290340000643 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290340000644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000645 FAD dependent oxidoreductase; Region: DAO; pfam01266 290340000646 Flavin Reductases; Region: FlaRed; cl00801 290340000647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340000648 classical (c) SDRs; Region: SDR_c; cd05233 290340000649 NAD(P) binding site [chemical binding]; other site 290340000650 active site 290340000651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340000654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000655 DNA-binding site [nucleotide binding]; DNA binding site 290340000656 FCD domain; Region: FCD; cl11656 290340000657 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000658 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 290340000659 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 290340000660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000661 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 290340000662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290340000663 active site 290340000664 intersubunit interface [polypeptide binding]; other site 290340000665 zinc binding site [ion binding]; other site 290340000666 Na+ binding site [ion binding]; other site 290340000667 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 290340000668 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 290340000669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000670 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340000671 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340000672 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000674 Putative zinc-finger; Region: zf-HC2; cl15806 290340000675 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340000676 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340000677 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340000678 Invertebrate innate immunity transcript family; Region: Innate_immun; pfam12782 290340000679 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 290340000680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340000681 catalytic residue [active] 290340000682 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 290340000683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340000685 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290340000686 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290340000687 IucA / IucC family; Region: IucA_IucC; pfam04183 290340000688 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290340000689 classical (c) SDRs; Region: SDR_c; cd05233 290340000690 NAD(P) binding site [chemical binding]; other site 290340000691 active site 290340000692 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 290340000693 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 290340000694 putative hydrophobic ligand binding site [chemical binding]; other site 290340000695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340000696 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340000697 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 290340000698 putative dimer interface [polypeptide binding]; other site 290340000699 ligand binding site [chemical binding]; other site 290340000700 Zn binding site [ion binding]; other site 290340000701 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290340000702 EamA-like transporter family; Region: EamA; cl01037 290340000703 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290340000704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000705 DNA-binding site [nucleotide binding]; DNA binding site 290340000706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340000708 homodimer interface [polypeptide binding]; other site 290340000709 catalytic residue [active] 290340000710 proline/glycine betaine transporter; Provisional; Region: PRK10642 290340000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000712 putative substrate translocation pore; other site 290340000713 putative methyltransferase; Provisional; Region: PRK14968 290340000714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340000715 S-adenosylmethionine binding site [chemical binding]; other site 290340000716 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 290340000717 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 290340000718 nucleotide binding site [chemical binding]; other site 290340000719 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 290340000720 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 290340000721 active site 290340000722 DNA binding site [nucleotide binding] 290340000723 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 290340000724 DNA binding site [nucleotide binding] 290340000725 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 290340000726 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 290340000727 putative DNA binding site [nucleotide binding]; other site 290340000728 putative homodimer interface [polypeptide binding]; other site 290340000729 transcription termination factor Rho; Provisional; Region: PRK12678 290340000730 Ferritin-like domain; Region: Ferritin; pfam00210 290340000731 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290340000732 dimerization interface [polypeptide binding]; other site 290340000733 DPS ferroxidase diiron center [ion binding]; other site 290340000734 ion pore; other site 290340000735 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 290340000736 active site 290340000737 DNA binding site [nucleotide binding] 290340000738 Int/Topo IB signature motif; other site 290340000739 catalytic residues [active] 290340000740 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340000741 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340000742 dimerization domain swap beta strand [polypeptide binding]; other site 290340000743 regulatory protein interface [polypeptide binding]; other site 290340000744 active site 290340000745 regulatory phosphorylation site [posttranslational modification]; other site 290340000746 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 290340000747 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340000748 active site 290340000749 phosphorylation site [posttranslational modification] 290340000750 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290340000751 active site 290340000752 P-loop; other site 290340000753 phosphorylation site [posttranslational modification] 290340000754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 290340000755 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290340000756 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340000757 putative substrate binding site [chemical binding]; other site 290340000758 putative ATP binding site [chemical binding]; other site 290340000759 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340000760 Helix-turn-helix domains; Region: HTH; cl00088 290340000761 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340000762 GAF domain; Region: GAF_2; pfam13185 290340000763 GAF domain; Region: GAF; cl15785 290340000764 ANTAR domain; Region: ANTAR; cl04297 290340000765 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 290340000766 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340000767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000768 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340000769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000771 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 290340000772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340000773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000775 DNA binding site [nucleotide binding] 290340000776 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000777 dimerization interface [polypeptide binding]; other site 290340000778 ligand binding site [chemical binding]; other site 290340000779 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290340000780 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290340000781 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290340000782 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290340000783 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340000784 Helix-turn-helix domains; Region: HTH; cl00088 290340000785 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 290340000786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340000787 S-adenosylmethionine binding site [chemical binding]; other site 290340000788 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290340000789 active site 290340000790 dimer interface [polypeptide binding]; other site 290340000791 motif 2; other site 290340000792 motif 3; other site 290340000793 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 290340000794 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340000795 Helix-turn-helix domains; Region: HTH; cl00088 290340000796 UbiA prenyltransferase family; Region: UbiA; cl00337 290340000797 phytoene desaturase; Region: crtI_fam; TIGR02734 290340000798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000799 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 290340000800 active site lid residues [active] 290340000801 substrate binding pocket [chemical binding]; other site 290340000802 catalytic residues [active] 290340000803 substrate-Mg2+ binding site; other site 290340000804 aspartate-rich region 1; other site 290340000805 aspartate-rich region 2; other site 290340000806 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340000807 substrate binding pocket [chemical binding]; other site 290340000808 chain length determination region; other site 290340000809 substrate-Mg2+ binding site; other site 290340000810 catalytic residues [active] 290340000811 aspartate-rich region 1; other site 290340000812 active site lid residues [active] 290340000813 aspartate-rich region 2; other site 290340000814 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 290340000815 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 290340000816 active site 290340000817 metal binding site [ion binding]; metal-binding site 290340000818 nudix motif; other site 290340000819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340000820 Helix-turn-helix domains; Region: HTH; cl00088 290340000821 CAAX protease self-immunity; Region: Abi; cl00558 290340000822 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340000823 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 290340000824 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 290340000825 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 290340000826 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340000827 active site 290340000828 catalytic triad [active] 290340000829 oxyanion hole [active] 290340000830 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290340000831 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 290340000832 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340000833 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340000834 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 290340000835 Cupin domain; Region: Cupin_2; cl09118 290340000836 Cupin domain; Region: Cupin_2; cl09118 290340000837 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340000838 Helix-turn-helix domains; Region: HTH; cl00088 290340000839 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340000840 benzoate transport; Region: 2A0115; TIGR00895 290340000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000842 putative substrate translocation pore; other site 290340000843 salicylate hydroxylase; Provisional; Region: PRK08163 290340000844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000845 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 290340000846 Helix-turn-helix domains; Region: HTH; cl00088 290340000847 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 290340000848 putative substrate binding pocket [chemical binding]; other site 290340000849 putative dimerization interface [polypeptide binding]; other site 290340000850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000851 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340000852 putative substrate translocation pore; other site 290340000853 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340000854 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 290340000855 putative active site [active] 290340000856 catalytic triad [active] 290340000857 putative dimer interface [polypeptide binding]; other site 290340000858 Glycoprotein hormone beta chain homologues; Region: GHB_like; cl00070 290340000859 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 290340000860 Helix-turn-helix domains; Region: HTH; cl00088 290340000861 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340000862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000864 active site 290340000865 catalytic tetrad [active] 290340000866 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340000867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000868 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340000869 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 290340000870 putative NAD(P) binding site [chemical binding]; other site 290340000871 putative substrate binding site [chemical binding]; other site 290340000872 catalytic Zn binding site [ion binding]; other site 290340000873 structural Zn binding site [ion binding]; other site 290340000874 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 290340000875 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340000876 putative active site [active] 290340000877 catalytic triad [active] 290340000878 putative dimer interface [polypeptide binding]; other site 290340000879 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 290340000880 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340000881 TM-ABC transporter signature motif; other site 290340000882 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340000883 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340000884 Walker A/P-loop; other site 290340000885 ATP binding site [chemical binding]; other site 290340000886 Q-loop/lid; other site 290340000887 ABC transporter signature motif; other site 290340000888 Walker B; other site 290340000889 D-loop; other site 290340000890 H-loop/switch region; other site 290340000891 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340000892 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290340000893 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340000894 ligand binding site [chemical binding]; other site 290340000895 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340000896 putative substrate binding site [chemical binding]; other site 290340000897 putative ATP binding site [chemical binding]; other site 290340000898 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 290340000899 Helix-turn-helix domains; Region: HTH; cl00088 290340000900 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340000901 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 290340000902 putative N- and C-terminal domain interface [polypeptide binding]; other site 290340000903 putative active site [active] 290340000904 putative MgATP binding site [chemical binding]; other site 290340000905 catalytic site [active] 290340000906 metal binding site [ion binding]; metal-binding site 290340000907 putative carbohydrate binding site [chemical binding]; other site 290340000908 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290340000909 hypothetical protein; Provisional; Region: PRK08185 290340000910 intersubunit interface [polypeptide binding]; other site 290340000911 active site 290340000912 zinc binding site [ion binding]; other site 290340000913 Na+ binding site [ion binding]; other site 290340000914 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 290340000915 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340000916 active site 290340000917 catalytic residues [active] 290340000918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340000919 Dehydratase family; Region: ILVD_EDD; cl00340 290340000920 thiamine pyrophosphate protein; Provisional; Region: PRK08273 290340000921 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290340000922 PYR/PP interface [polypeptide binding]; other site 290340000923 dimer interface [polypeptide binding]; other site 290340000924 tetramer interface [polypeptide binding]; other site 290340000925 TPP binding site [chemical binding]; other site 290340000926 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340000927 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340000928 TPP-binding site [chemical binding]; other site 290340000929 ANTAR domain; Region: ANTAR; cl04297 290340000930 META domain; Region: META; cl01245 290340000931 Glutaminase; Region: Glutaminase; cl00907 290340000932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000933 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340000934 putative substrate translocation pore; other site 290340000935 LamB/YcsF family; Region: LamB_YcsF; cl00664 290340000936 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 290340000937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340000938 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 290340000939 putative dimer interface [polypeptide binding]; other site 290340000940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000941 Protein of unknown function (DUF445); Region: DUF445; pfam04286 290340000942 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 290340000943 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290340000944 active site 290340000945 catalytic site [active] 290340000946 AzlC protein; Region: AzlC; cl00570 290340000947 Domain of unknown function DUF77; Region: DUF77; cl00307 290340000948 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340000949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340000951 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340000952 Cupin superfamily protein; Region: Cupin_4; pfam08007 290340000953 JmjC domain, hydroxylase; Region: JmjC; cl15814 290340000954 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 290340000955 putative dimer interface [polypeptide binding]; other site 290340000956 putative [2Fe-2S] cluster binding site [ion binding]; other site 290340000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340000958 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340000959 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340000960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340000961 Walker A/P-loop; other site 290340000962 ATP binding site [chemical binding]; other site 290340000963 Q-loop/lid; other site 290340000964 ABC transporter signature motif; other site 290340000965 Walker B; other site 290340000966 D-loop; other site 290340000967 H-loop/switch region; other site 290340000968 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340000969 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340000970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340000971 Walker A/P-loop; other site 290340000972 ATP binding site [chemical binding]; other site 290340000973 Q-loop/lid; other site 290340000974 ABC transporter signature motif; other site 290340000975 Walker B; other site 290340000976 D-loop; other site 290340000977 H-loop/switch region; other site 290340000978 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340000979 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340000980 FAD binding pocket [chemical binding]; other site 290340000981 FAD binding motif [chemical binding]; other site 290340000982 phosphate binding motif [ion binding]; other site 290340000983 NAD binding pocket [chemical binding]; other site 290340000984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340000985 ABC-ATPase subunit interface; other site 290340000986 dimer interface [polypeptide binding]; other site 290340000987 putative PBP binding regions; other site 290340000988 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290340000989 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340000990 ABC-ATPase subunit interface; other site 290340000991 dimer interface [polypeptide binding]; other site 290340000992 putative PBP binding regions; other site 290340000993 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 290340000994 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340000995 Walker A/P-loop; other site 290340000996 ATP binding site [chemical binding]; other site 290340000997 Q-loop/lid; other site 290340000998 ABC transporter signature motif; other site 290340000999 Walker B; other site 290340001000 D-loop; other site 290340001001 H-loop/switch region; other site 290340001002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001003 Helix-turn-helix domains; Region: HTH; cl00088 290340001004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001005 dimerization interface [polypeptide binding]; other site 290340001006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001007 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001008 putative substrate translocation pore; other site 290340001009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001010 NAD(P) binding site [chemical binding]; other site 290340001011 active site 290340001012 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340001013 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001014 active site 290340001015 putative proline-specific permease; Provisional; Region: proY; PRK10580 290340001016 Spore germination protein; Region: Spore_permease; cl15802 290340001017 Short repeats of unknown function; Region: ALF; pfam03752 290340001018 Short repeats of unknown function; Region: ALF; pfam03752 290340001019 Short repeats of unknown function; Region: ALF; pfam03752 290340001020 Short repeats of unknown function; Region: ALF; pfam03752 290340001021 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001022 Helix-turn-helix domains; Region: HTH; cl00088 290340001023 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001024 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340001025 putative hydrophobic ligand binding site [chemical binding]; other site 290340001026 urocanate hydratase; Provisional; Region: PRK05414 290340001027 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290340001028 active sites [active] 290340001029 tetramer interface [polypeptide binding]; other site 290340001030 Arginase family; Region: Arginase; cl00306 290340001031 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340001032 Bacterial Ig-like domain; Region: Big_5; cl01012 290340001033 NlpC/P60 family; Region: NLPC_P60; cl11438 290340001034 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 290340001035 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001036 Ligand Binding Site [chemical binding]; other site 290340001037 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290340001038 phosphoenolpyruvate synthase; Validated; Region: PRK06241 290340001039 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290340001040 Cation efflux family; Region: Cation_efflux; cl00316 290340001041 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 290340001042 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001043 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340001044 putative substrate binding site [chemical binding]; other site 290340001045 putative ATP binding site [chemical binding]; other site 290340001046 EamA-like transporter family; Region: EamA; cl01037 290340001047 EamA-like transporter family; Region: EamA; cl01037 290340001048 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 290340001049 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340001050 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340001051 catalytic residues [active] 290340001052 catalytic nucleophile [active] 290340001053 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340001054 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340001055 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340001056 Synaptic Site I dimer interface [polypeptide binding]; other site 290340001057 DNA binding site [nucleotide binding] 290340001058 Helix-turn-helix domains; Region: HTH; cl00088 290340001059 DNA-binding interface [nucleotide binding]; DNA binding site 290340001060 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 290340001061 nucleotide binding site/active site [active] 290340001062 HIT family signature motif; other site 290340001063 catalytic residue [active] 290340001064 TIR domain; Region: TIR_2; cl15770 290340001065 Abi-like protein; Region: Abi_2; cl01988 290340001066 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 290340001067 catalytic residues [active] 290340001068 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340001069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290340001070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001072 DNA binding residues [nucleotide binding] 290340001073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001074 Helix-turn-helix domains; Region: HTH; cl00088 290340001075 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 290340001076 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340001077 RHS Repeat; Region: RHS_repeat; cl11982 290340001078 RHS Repeat; Region: RHS_repeat; cl11982 290340001079 RHS Repeat; Region: RHS_repeat; cl11982 290340001080 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 290340001081 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 290340001082 putative active site [active] 290340001083 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340001084 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001085 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340001086 substrate binding site [chemical binding]; other site 290340001087 ATP binding site [chemical binding]; other site 290340001088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001090 DNA binding site [nucleotide binding] 290340001091 domain linker motif; other site 290340001092 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001093 dimerization interface [polypeptide binding]; other site 290340001094 ligand binding site [chemical binding]; other site 290340001095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001096 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001098 dimer interface [polypeptide binding]; other site 290340001099 conserved gate region; other site 290340001100 putative PBP binding loops; other site 290340001101 ABC-ATPase subunit interface; other site 290340001102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001104 dimer interface [polypeptide binding]; other site 290340001105 conserved gate region; other site 290340001106 putative PBP binding loops; other site 290340001107 ABC-ATPase subunit interface; other site 290340001108 Asp23 family; Region: Asp23; cl00574 290340001109 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 290340001110 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 290340001111 active site 290340001112 putative catalytic site [active] 290340001113 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340001114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340001115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340001116 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290340001117 active site 290340001118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340001119 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001122 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340001123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001124 dimer interface [polypeptide binding]; other site 290340001125 conserved gate region; other site 290340001126 putative PBP binding loops; other site 290340001127 ABC-ATPase subunit interface; other site 290340001128 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001130 dimer interface [polypeptide binding]; other site 290340001131 conserved gate region; other site 290340001132 putative PBP binding loops; other site 290340001133 ABC-ATPase subunit interface; other site 290340001134 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340001136 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001137 dimerization interface [polypeptide binding]; other site 290340001138 ligand binding site [chemical binding]; other site 290340001139 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 290340001140 putative catalytic site [active] 290340001141 putative phosphate binding site [ion binding]; other site 290340001142 active site 290340001143 metal binding site A [ion binding]; metal-binding site 290340001144 DNA binding site [nucleotide binding] 290340001145 putative AP binding site [nucleotide binding]; other site 290340001146 putative metal binding site B [ion binding]; other site 290340001147 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 290340001148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001150 active site 290340001151 phosphorylation site [posttranslational modification] 290340001152 intermolecular recognition site; other site 290340001153 dimerization interface [polypeptide binding]; other site 290340001154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001155 DNA binding residues [nucleotide binding] 290340001156 Histidine kinase; Region: HisKA_3; pfam07730 290340001157 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290340001158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001159 ATP binding site [chemical binding]; other site 290340001160 G-X-G motif; other site 290340001161 Domain of unknown function (DUF336); Region: DUF336; cl01249 290340001162 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290340001163 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290340001164 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 290340001165 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 290340001166 active site 290340001167 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340001168 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340001169 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001170 Helix-turn-helix domains; Region: HTH; cl00088 290340001171 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340001173 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290340001174 Coenzyme A binding pocket [chemical binding]; other site 290340001175 Fasciclin domain; Region: Fasciclin; cl02663 290340001176 BCCT family transporter; Region: BCCT; cl00569 290340001177 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001178 Helix-turn-helix domains; Region: HTH; cl00088 290340001179 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001180 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340001181 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340001182 dimer interface [polypeptide binding]; other site 290340001183 putative functional site; other site 290340001184 putative MPT binding site; other site 290340001185 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 290340001186 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 290340001187 NAD binding site [chemical binding]; other site 290340001188 catalytic Zn binding site [ion binding]; other site 290340001189 structural Zn binding site [ion binding]; other site 290340001190 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340001191 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340001192 putative molybdopterin cofactor binding site [chemical binding]; other site 290340001193 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340001194 putative molybdopterin cofactor binding site; other site 290340001195 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 290340001196 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290340001197 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290340001198 homodimer interface [polypeptide binding]; other site 290340001199 NADP binding site [chemical binding]; other site 290340001200 substrate binding site [chemical binding]; other site 290340001201 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 290340001202 FAD dependent oxidoreductase; Region: DAO; pfam01266 290340001203 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 290340001204 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340001205 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340001206 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340001207 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340001208 putative active site [active] 290340001209 putative substrate binding site [chemical binding]; other site 290340001210 putative cosubstrate binding site; other site 290340001211 catalytic site [active] 290340001212 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340001213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340001214 DNA-binding site [nucleotide binding]; DNA binding site 290340001215 FCD domain; Region: FCD; cl11656 290340001216 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290340001217 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290340001218 active site 290340001219 multimer interface [polypeptide binding]; other site 290340001220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001221 Helix-turn-helix domains; Region: HTH; cl00088 290340001222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340001223 putative dimerization interface [polypeptide binding]; other site 290340001224 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290340001225 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 290340001226 [2Fe-2S] cluster binding site [ion binding]; other site 290340001227 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 290340001228 putative alpha subunit interface [polypeptide binding]; other site 290340001229 putative active site [active] 290340001230 putative substrate binding site [chemical binding]; other site 290340001231 Fe binding site [ion binding]; other site 290340001232 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290340001233 FAD binding pocket [chemical binding]; other site 290340001234 FAD binding motif [chemical binding]; other site 290340001235 phosphate binding motif [ion binding]; other site 290340001236 beta-alpha-beta structure motif; other site 290340001237 NAD binding pocket [chemical binding]; other site 290340001238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340001239 catalytic loop [active] 290340001240 iron binding site [ion binding]; other site 290340001241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340001242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001243 DNA binding residues [nucleotide binding] 290340001244 dimerization interface [polypeptide binding]; other site 290340001245 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 290340001246 tetramer interface [polypeptide binding]; other site 290340001247 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 290340001248 active site 290340001249 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 290340001250 active site 290340001251 dimer interface [polypeptide binding]; other site 290340001252 magnesium binding site [ion binding]; other site 290340001253 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 290340001254 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 290340001255 DNA photolyase; Region: DNA_photolyase; pfam00875 290340001256 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 290340001257 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340001258 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001259 tetrameric interface [polypeptide binding]; other site 290340001260 NAD binding site [chemical binding]; other site 290340001261 catalytic residues [active] 290340001262 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 290340001263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340001264 substrate binding site [chemical binding]; other site 290340001265 oxyanion hole (OAH) forming residues; other site 290340001266 trimer interface [polypeptide binding]; other site 290340001267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 290340001268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001269 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 290340001270 enoyl-CoA hydratase; Provisional; Region: PRK05862 290340001271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340001272 substrate binding site [chemical binding]; other site 290340001273 oxyanion hole (OAH) forming residues; other site 290340001274 trimer interface [polypeptide binding]; other site 290340001275 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340001276 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 290340001277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001278 Ligand Binding Site [chemical binding]; other site 290340001279 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290340001280 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001281 active site 290340001282 Helix-turn-helix domains; Region: HTH; cl00088 290340001283 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290340001284 AMP-binding enzyme; Region: AMP-binding; cl15778 290340001285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340001286 acyl-coenzyme A oxidase; Region: PLN02526 290340001287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340001288 active site 290340001289 Spore germination protein; Region: Spore_permease; cl15802 290340001290 choline dehydrogenase; Validated; Region: PRK02106 290340001291 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290340001292 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 290340001293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001294 tetramerization interface [polypeptide binding]; other site 290340001295 NAD(P) binding site [chemical binding]; other site 290340001296 catalytic residues [active] 290340001297 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 290340001298 Moco binding site; other site 290340001299 metal coordination site [ion binding]; other site 290340001300 dimerization interface [polypeptide binding]; other site 290340001301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001302 Helix-turn-helix domains; Region: HTH; cl00088 290340001303 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340001304 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 290340001305 DNA binding residues [nucleotide binding] 290340001306 dimer interface [polypeptide binding]; other site 290340001307 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 290340001308 Helix-turn-helix domains; Region: HTH; cl00088 290340001309 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 290340001310 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290340001311 homodimer interface [polypeptide binding]; other site 290340001312 NAD binding pocket [chemical binding]; other site 290340001313 ATP binding pocket [chemical binding]; other site 290340001314 Mg binding site [ion binding]; other site 290340001315 active-site loop [active] 290340001316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001318 DNA binding site [nucleotide binding] 290340001319 domain linker motif; other site 290340001320 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001321 ligand binding site [chemical binding]; other site 290340001322 dimerization interface [polypeptide binding]; other site 290340001323 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001325 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001327 dimer interface [polypeptide binding]; other site 290340001328 conserved gate region; other site 290340001329 putative PBP binding loops; other site 290340001330 ABC-ATPase subunit interface; other site 290340001331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001333 dimer interface [polypeptide binding]; other site 290340001334 conserved gate region; other site 290340001335 putative PBP binding loops; other site 290340001336 ABC-ATPase subunit interface; other site 290340001337 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340001338 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340001341 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340001342 Glucuronate isomerase; Region: UxaC; cl00829 290340001343 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290340001344 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290340001345 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290340001346 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290340001347 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 290340001348 putative active site pocket [active] 290340001349 putative metal binding site [ion binding]; other site 290340001350 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 290340001351 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290340001352 ATP-binding site [chemical binding]; other site 290340001353 Gluconate-6-phosphate binding site [chemical binding]; other site 290340001354 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 290340001355 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290340001356 putative ligand binding site [chemical binding]; other site 290340001357 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 290340001358 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340001359 Walker A/P-loop; other site 290340001360 ATP binding site [chemical binding]; other site 290340001361 Q-loop/lid; other site 290340001362 ABC transporter signature motif; other site 290340001363 Walker B; other site 290340001364 D-loop; other site 290340001365 H-loop/switch region; other site 290340001366 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340001367 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340001368 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340001369 TM-ABC transporter signature motif; other site 290340001370 lac repressor; Reviewed; Region: lacI; PRK09526 290340001371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001372 DNA binding site [nucleotide binding] 290340001373 domain linker motif; other site 290340001374 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290340001375 ligand binding site [chemical binding]; other site 290340001376 dimerization interface (open form) [polypeptide binding]; other site 290340001377 dimerization interface (closed form) [polypeptide binding]; other site 290340001378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 290340001379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340001380 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 290340001381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340001382 Walker A/P-loop; other site 290340001383 ATP binding site [chemical binding]; other site 290340001384 Q-loop/lid; other site 290340001385 ABC transporter signature motif; other site 290340001386 Walker B; other site 290340001387 D-loop; other site 290340001388 H-loop/switch region; other site 290340001389 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 290340001390 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340001391 active site 290340001392 ATP binding site [chemical binding]; other site 290340001393 substrate binding site [chemical binding]; other site 290340001394 Flavoprotein; Region: Flavoprotein; cl08021 290340001395 Phosphotransferase enzyme family; Region: APH; pfam01636 290340001396 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290340001397 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290340001398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001400 active site 290340001401 phosphorylation site [posttranslational modification] 290340001402 intermolecular recognition site; other site 290340001403 dimerization interface [polypeptide binding]; other site 290340001404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001405 DNA binding residues [nucleotide binding] 290340001406 dimerization interface [polypeptide binding]; other site 290340001407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340001408 Histidine kinase; Region: HisKA_3; pfam07730 290340001409 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340001410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340001411 UMP phosphatase; Provisional; Region: PRK10444 290340001412 active site 290340001413 motif I; other site 290340001414 motif II; other site 290340001415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340001416 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 290340001417 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290340001418 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290340001419 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 290340001420 active site 290340001421 intersubunit interface [polypeptide binding]; other site 290340001422 zinc binding site [ion binding]; other site 290340001423 Na+ binding site [ion binding]; other site 290340001424 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 290340001425 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 290340001426 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340001427 Walker A/P-loop; other site 290340001428 ATP binding site [chemical binding]; other site 290340001429 Q-loop/lid; other site 290340001430 ABC transporter signature motif; other site 290340001431 Walker B; other site 290340001432 D-loop; other site 290340001433 H-loop/switch region; other site 290340001434 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290340001435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001436 ABC-ATPase subunit interface; other site 290340001437 dimer interface [polypeptide binding]; other site 290340001438 putative PBP binding regions; other site 290340001439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001440 ABC-ATPase subunit interface; other site 290340001441 dimer interface [polypeptide binding]; other site 290340001442 putative PBP binding regions; other site 290340001443 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 290340001444 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290340001445 siderophore binding site; other site 290340001446 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 290340001447 ligand binding site [chemical binding]; other site 290340001448 active site 290340001449 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290340001450 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290340001451 GDP-binding site [chemical binding]; other site 290340001452 ACT binding site; other site 290340001453 IMP binding site; other site 290340001454 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 290340001455 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340001456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001457 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 290340001458 Strictosidine synthase; Region: Str_synth; pfam03088 290340001459 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 290340001460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001461 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340001462 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 290340001463 Helix-turn-helix domains; Region: HTH; cl00088 290340001464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340001465 dimerization interface [polypeptide binding]; other site 290340001466 malate dehydrogenase; Provisional; Region: PRK05442 290340001467 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 290340001468 NAD(P) binding site [chemical binding]; other site 290340001469 dimer interface [polypeptide binding]; other site 290340001470 malate binding site [chemical binding]; other site 290340001471 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 290340001472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001473 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290340001474 Aspartase; Region: Aspartase; cd01357 290340001475 active sites [active] 290340001476 tetramer interface [polypeptide binding]; other site 290340001477 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 290340001478 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340001479 metal binding site [ion binding]; metal-binding site 290340001480 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 290340001481 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340001482 homotrimer interaction site [polypeptide binding]; other site 290340001483 putative active site [active] 290340001484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001485 Helix-turn-helix domains; Region: HTH; cl00088 290340001486 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 290340001487 putative substrate binding pocket [chemical binding]; other site 290340001488 dimerization interface [polypeptide binding]; other site 290340001489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001490 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001491 putative substrate translocation pore; other site 290340001492 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340001493 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340001494 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340001495 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340001496 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 290340001497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001498 NAD(P) binding site [chemical binding]; other site 290340001499 catalytic residues [active] 290340001500 Amino acid permease; Region: AA_permease_2; pfam13520 290340001501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001502 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001503 putative substrate translocation pore; other site 290340001504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340001505 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340001506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001507 Helix-turn-helix domains; Region: HTH; cl00088 290340001508 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 290340001509 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 290340001510 active site 290340001511 catalytic site [active] 290340001512 Uncharacterized conserved protein [Function unknown]; Region: COG4850 290340001513 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 290340001514 CAAX protease self-immunity; Region: Abi; cl00558 290340001515 PHP domain; Region: PHP; pfam02811 290340001516 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290340001517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001518 dimerization interface [polypeptide binding]; other site 290340001519 ligand binding site [chemical binding]; other site 290340001520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340001521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340001522 substrate binding pocket [chemical binding]; other site 290340001523 membrane-bound complex binding site; other site 290340001524 hinge residues; other site 290340001525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001527 dimer interface [polypeptide binding]; other site 290340001528 conserved gate region; other site 290340001529 putative PBP binding loops; other site 290340001530 ABC-ATPase subunit interface; other site 290340001531 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340001532 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340001533 Walker A/P-loop; other site 290340001534 ATP binding site [chemical binding]; other site 290340001535 Q-loop/lid; other site 290340001536 ABC transporter signature motif; other site 290340001537 Walker B; other site 290340001538 D-loop; other site 290340001539 H-loop/switch region; other site 290340001540 putative oxidoreductase; Provisional; Region: PRK11579 290340001541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001542 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340001543 FAD dependent oxidoreductase; Region: DAO; pfam01266 290340001544 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340001545 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 290340001546 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 290340001547 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 290340001548 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 290340001549 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001550 active site 290340001551 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340001552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340001553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340001554 DNA binding residues [nucleotide binding] 290340001555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001556 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 290340001557 NodB motif; other site 290340001558 active site 290340001559 catalytic site [active] 290340001560 metal binding site [ion binding]; metal-binding site 290340001561 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340001562 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 290340001563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001564 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340001565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001566 dimer interface [polypeptide binding]; other site 290340001567 conserved gate region; other site 290340001568 putative PBP binding loops; other site 290340001569 ABC-ATPase subunit interface; other site 290340001570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001572 dimer interface [polypeptide binding]; other site 290340001573 conserved gate region; other site 290340001574 putative PBP binding loops; other site 290340001575 ABC-ATPase subunit interface; other site 290340001576 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 290340001577 Flavin Reductases; Region: FlaRed; cl00801 290340001578 Cupin domain; Region: Cupin_2; cl09118 290340001579 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 290340001580 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 290340001581 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 290340001582 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340001583 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 290340001584 putative active site [active] 290340001585 catalytic triad [active] 290340001586 putative dimer interface [polypeptide binding]; other site 290340001587 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001589 putative substrate translocation pore; other site 290340001590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340001591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340001592 DNA-binding site [nucleotide binding]; DNA binding site 290340001593 FCD domain; Region: FCD; cl11656 290340001594 Protein of unknown function (DUF503); Region: DUF503; cl00669 290340001595 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 290340001596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340001597 metal binding site [ion binding]; metal-binding site 290340001598 active site 290340001599 I-site; other site 290340001600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340001601 metal binding site [ion binding]; metal-binding site 290340001602 active site 290340001603 I-site; other site 290340001604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340001605 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 290340001606 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290340001607 dimerization interface [polypeptide binding]; other site 290340001608 ATP binding site [chemical binding]; other site 290340001609 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 290340001610 dimerization interface [polypeptide binding]; other site 290340001611 ATP binding site [chemical binding]; other site 290340001612 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290340001613 putative active site [active] 290340001614 catalytic triad [active] 290340001615 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 290340001616 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 290340001617 dinuclear metal binding motif [ion binding]; other site 290340001618 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 290340001619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001620 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290340001621 catalytic site [active] 290340001622 BNR repeat-like domain; Region: BNR_2; pfam13088 290340001623 Asp-box motif; other site 290340001624 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340001625 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290340001626 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 290340001627 active site 290340001628 catalytic triad [active] 290340001629 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 290340001630 PA/protease or protease-like domain interface [polypeptide binding]; other site 290340001631 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290340001632 catalytic residues [active] 290340001633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340001634 Helix-turn-helix domains; Region: HTH; cl00088 290340001635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001636 dimer interface [polypeptide binding]; other site 290340001637 conserved gate region; other site 290340001638 putative PBP binding loops; other site 290340001639 ABC-ATPase subunit interface; other site 290340001640 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290340001641 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 290340001642 Walker A/P-loop; other site 290340001643 ATP binding site [chemical binding]; other site 290340001644 Q-loop/lid; other site 290340001645 ABC transporter signature motif; other site 290340001646 Walker B; other site 290340001647 D-loop; other site 290340001648 H-loop/switch region; other site 290340001649 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001651 dimer interface [polypeptide binding]; other site 290340001652 conserved gate region; other site 290340001653 putative PBP binding loops; other site 290340001654 ABC-ATPase subunit interface; other site 290340001655 NMT1-like family; Region: NMT1_2; cl15260 290340001656 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290340001657 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 290340001658 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340001659 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340001660 active site pocket [active] 290340001661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001662 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 290340001663 NAD(P) binding site [chemical binding]; other site 290340001664 catalytic residues [active] 290340001665 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290340001666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001667 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340001668 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290340001669 active site 290340001670 NAD binding site [chemical binding]; other site 290340001671 metal binding site [ion binding]; metal-binding site 290340001672 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001673 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340001674 tetramerization interface [polypeptide binding]; other site 290340001675 NAD(P) binding site [chemical binding]; other site 290340001676 catalytic residues [active] 290340001677 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340001678 classical (c) SDRs; Region: SDR_c; cd05233 290340001679 NAD(P) binding site [chemical binding]; other site 290340001680 active site 290340001681 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340001682 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340001683 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340001684 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340001685 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340001686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001687 putative substrate translocation pore; other site 290340001688 aspartate kinase; Reviewed; Region: PRK06635 290340001689 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 290340001690 putative nucleotide binding site [chemical binding]; other site 290340001691 putative catalytic residues [active] 290340001692 putative Mg ion binding site [ion binding]; other site 290340001693 putative aspartate binding site [chemical binding]; other site 290340001694 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 290340001695 putative allosteric regulatory site; other site 290340001696 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 290340001697 putative allosteric regulatory residue; other site 290340001698 Domain of unknown function (DUF427); Region: DUF427; cl00998 290340001699 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340001700 NADP+ binding site [chemical binding]; other site 290340001701 folate binding site [chemical binding]; other site 290340001702 recombination protein RecR; Reviewed; Region: recR; PRK00076 290340001703 RecR protein; Region: RecR; pfam02132 290340001704 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290340001705 putative active site [active] 290340001706 putative metal-binding site [ion binding]; other site 290340001707 tetramer interface [polypeptide binding]; other site 290340001708 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 290340001709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340001710 Walker A motif; other site 290340001711 ATP binding site [chemical binding]; other site 290340001712 Walker B motif; other site 290340001713 arginine finger; other site 290340001714 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 290340001715 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 290340001716 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 290340001717 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 290340001718 OpgC protein; Region: OpgC_C; cl00792 290340001719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001720 Helix-turn-helix domains; Region: HTH; cl00088 290340001721 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340001722 putative dimerization interface [polypeptide binding]; other site 290340001723 Proline dehydrogenase; Region: Pro_dh; cl03282 290340001724 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340001725 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001726 NAD(P) binding site [chemical binding]; other site 290340001727 catalytic residues [active] 290340001728 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 290340001729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340001730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001731 Helix-turn-helix domains; Region: HTH; cl00088 290340001732 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340001733 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 290340001734 catalytic residues [active] 290340001735 dimer interface [polypeptide binding]; other site 290340001736 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290340001737 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290340001738 hexamer interface [polypeptide binding]; other site 290340001739 active site 290340001740 metal binding site [ion binding]; metal-binding site 290340001741 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 290340001742 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 290340001743 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340001744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001745 Helix-turn-helix domains; Region: HTH; cl00088 290340001746 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001747 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001748 DNA binding site [nucleotide binding] 290340001749 domain linker motif; other site 290340001750 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001751 dimerization interface [polypeptide binding]; other site 290340001752 ligand binding site [chemical binding]; other site 290340001753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340001754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001755 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 290340001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001757 putative PBP binding loops; other site 290340001758 dimer interface [polypeptide binding]; other site 290340001759 ABC-ATPase subunit interface; other site 290340001760 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001762 dimer interface [polypeptide binding]; other site 290340001763 conserved gate region; other site 290340001764 putative PBP binding loops; other site 290340001765 ABC-ATPase subunit interface; other site 290340001766 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290340001767 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 290340001768 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 290340001769 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 290340001770 catalytic residues [active] 290340001771 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290340001772 putative ADP-binding pocket [chemical binding]; other site 290340001773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340001774 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 290340001775 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340001776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340001777 Coenzyme A binding pocket [chemical binding]; other site 290340001778 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340001779 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340001780 substrate binding [chemical binding]; other site 290340001781 active site 290340001782 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340001783 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001784 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340001785 putative substrate binding site [chemical binding]; other site 290340001786 putative ATP binding site [chemical binding]; other site 290340001787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001789 DNA binding site [nucleotide binding] 290340001790 domain linker motif; other site 290340001791 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340001792 putative dimerization interface [polypeptide binding]; other site 290340001793 putative ligand binding site [chemical binding]; other site 290340001794 Right handed beta helix region; Region: Beta_helix; pfam13229 290340001795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001797 dimer interface [polypeptide binding]; other site 290340001798 conserved gate region; other site 290340001799 putative PBP binding loops; other site 290340001800 ABC-ATPase subunit interface; other site 290340001801 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001803 dimer interface [polypeptide binding]; other site 290340001804 conserved gate region; other site 290340001805 putative PBP binding loops; other site 290340001806 ABC-ATPase subunit interface; other site 290340001807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001809 Ligand Binding Site [chemical binding]; other site 290340001810 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 290340001811 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290340001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 290340001813 NMT1-like family; Region: NMT1_2; cl15260 290340001814 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290340001815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290340001816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001817 ATP binding site [chemical binding]; other site 290340001818 Mg2+ binding site [ion binding]; other site 290340001819 G-X-G motif; other site 290340001820 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001822 active site 290340001823 phosphorylation site [posttranslational modification] 290340001824 intermolecular recognition site; other site 290340001825 dimerization interface [polypeptide binding]; other site 290340001826 Helix-turn-helix domains; Region: HTH; cl00088 290340001827 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290340001828 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 290340001829 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 290340001830 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340001831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340001832 HipA N-terminal domain; Region: Couple_hipA; cl11853 290340001833 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290340001834 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290340001835 Domain of unknown function (DUF336); Region: DUF336; cl01249 290340001836 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001838 translocation protein TolB; Provisional; Region: tolB; PRK02889 290340001839 translocation protein TolB; Provisional; Region: tolB; PRK02889 290340001840 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340001841 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340001842 Metal-binding active site; metal-binding site 290340001843 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290340001844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340001847 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001849 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340001850 Helix-turn-helix domains; Region: HTH; cl00088 290340001851 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340001852 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340001853 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340001854 malate synthase A; Region: malate_syn_A; TIGR01344 290340001855 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290340001856 active site 290340001857 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340001858 tetramer interface [polypeptide binding]; other site 290340001859 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 290340001860 active site 290340001861 Mg2+/Mn2+ binding site [ion binding]; other site 290340001862 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340001863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340001864 non-specific DNA binding site [nucleotide binding]; other site 290340001865 salt bridge; other site 290340001866 sequence-specific DNA binding site [nucleotide binding]; other site 290340001867 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 290340001868 Domain of unknown function (DUF955); Region: DUF955; cl01076 290340001869 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 290340001870 reactive center loop; other site 290340001871 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 290340001872 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290340001873 dimer interface [polypeptide binding]; other site 290340001874 substrate binding site [chemical binding]; other site 290340001875 ATP binding site [chemical binding]; other site 290340001876 NMT1-like family; Region: NMT1_2; cl15260 290340001877 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 290340001878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290340001879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 290340001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001881 ATP binding site [chemical binding]; other site 290340001882 Mg2+ binding site [ion binding]; other site 290340001883 G-X-G motif; other site 290340001884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340001885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001886 active site 290340001887 phosphorylation site [posttranslational modification] 290340001888 intermolecular recognition site; other site 290340001889 dimerization interface [polypeptide binding]; other site 290340001890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340001891 DNA binding site [nucleotide binding] 290340001892 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 290340001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001894 putative substrate translocation pore; other site 290340001895 Phospholipid methyltransferase; Region: PEMT; cl00763 290340001896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001897 TIGR01777 family protein; Region: yfcH 290340001898 NAD(P) binding site [chemical binding]; other site 290340001899 active site 290340001900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001901 Helix-turn-helix domains; Region: HTH; cl00088 290340001902 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 290340001903 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 290340001904 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 290340001905 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340001906 putative hydrophobic ligand binding site [chemical binding]; other site 290340001907 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340001908 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340001909 homotrimer interaction site [polypeptide binding]; other site 290340001910 putative active site [active] 290340001911 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001913 putative substrate translocation pore; other site 290340001914 Helix-turn-helix domains; Region: HTH; cl00088 290340001915 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001917 putative substrate translocation pore; other site 290340001918 thiamine pyrophosphate protein; Validated; Region: PRK08199 290340001919 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340001920 PYR/PP interface [polypeptide binding]; other site 290340001921 dimer interface [polypeptide binding]; other site 290340001922 TPP binding site [chemical binding]; other site 290340001923 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340001924 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340001925 TPP-binding site [chemical binding]; other site 290340001926 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340001927 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001928 tetrameric interface [polypeptide binding]; other site 290340001929 NAD binding site [chemical binding]; other site 290340001930 catalytic residues [active] 290340001931 substrate binding site [chemical binding]; other site 290340001932 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340001933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340001934 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340001935 active site 290340001936 allantoate amidohydrolase; Reviewed; Region: PRK09290 290340001937 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 290340001938 active site 290340001939 metal binding site [ion binding]; metal-binding site 290340001940 dimer interface [polypeptide binding]; other site 290340001941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 290340001942 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340001943 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290340001944 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 290340001945 Walker A/P-loop; other site 290340001946 ATP binding site [chemical binding]; other site 290340001947 Q-loop/lid; other site 290340001948 ABC transporter signature motif; other site 290340001949 Walker B; other site 290340001950 D-loop; other site 290340001951 H-loop/switch region; other site 290340001952 TOBE domain; Region: TOBE_2; cl01440 290340001953 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290340001954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001955 dimer interface [polypeptide binding]; other site 290340001956 conserved gate region; other site 290340001957 putative PBP binding loops; other site 290340001958 ABC-ATPase subunit interface; other site 290340001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001960 dimer interface [polypeptide binding]; other site 290340001961 conserved gate region; other site 290340001962 putative PBP binding loops; other site 290340001963 ABC-ATPase subunit interface; other site 290340001964 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001966 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 290340001967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001969 NAD(P) binding site [chemical binding]; other site 290340001970 active site 290340001971 acyl-coenzyme A oxidase; Region: PLN02526 290340001972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340001973 active site 290340001974 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 290340001975 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340001976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340001977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340001978 Putative zinc-finger; Region: zf-HC2; cl15806 290340001979 cation transport protein; Region: 2A0119; TIGR00898 290340001980 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001982 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340001983 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 290340001984 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290340001985 DXD motif; other site 290340001986 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290340001987 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 290340001988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340001989 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 290340001990 ADP-ribose binding site [chemical binding]; other site 290340001991 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 290340001992 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 290340001993 probable active site [active] 290340001994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340001995 dimerization interface [polypeptide binding]; other site 290340001996 putative DNA binding site [nucleotide binding]; other site 290340001997 putative Zn2+ binding site [ion binding]; other site 290340001998 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340001999 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 290340002000 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290340002001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002002 DNA-binding site [nucleotide binding]; DNA binding site 290340002003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340002004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002005 homodimer interface [polypeptide binding]; other site 290340002006 catalytic residue [active] 290340002007 Predicted membrane protein [Function unknown]; Region: COG2364 290340002008 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 290340002009 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 290340002010 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290340002011 DXD motif; other site 290340002012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340002013 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 290340002014 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 290340002015 active site 290340002016 catalytic residues [active] 290340002017 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 290340002018 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 290340002019 putative sugar binding sites [chemical binding]; other site 290340002020 Q-X-W motif; other site 290340002021 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340002022 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 290340002023 putative DNA binding site [nucleotide binding]; other site 290340002024 catalytic residue [active] 290340002025 putative H2TH interface [polypeptide binding]; other site 290340002026 putative catalytic residues [active] 290340002027 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340002028 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290340002029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002030 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 290340002031 ATP binding site [chemical binding]; other site 290340002032 putative Mg++ binding site [ion binding]; other site 290340002033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002034 nucleotide binding region [chemical binding]; other site 290340002035 ATP-binding site [chemical binding]; other site 290340002036 DEAD/H associated; Region: DEAD_assoc; pfam08494 290340002037 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 290340002038 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 290340002039 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 290340002040 putative hydrophobic ligand binding site [chemical binding]; other site 290340002041 Restriction endonuclease; Region: Mrr_cat; cl00516 290340002042 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340002043 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290340002044 putative NAD(P) binding site [chemical binding]; other site 290340002045 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290340002046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340002047 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 290340002048 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 290340002049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002050 metal binding site [ion binding]; metal-binding site 290340002051 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340002052 nucleoside/Zn binding site; other site 290340002053 dimer interface [polypeptide binding]; other site 290340002054 catalytic motif [active] 290340002055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340002056 active site 290340002057 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340002058 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002059 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290340002060 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340002061 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 290340002062 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002064 catalytic residue [active] 290340002065 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 290340002066 Ligand binding site; other site 290340002067 Ligand binding site; other site 290340002068 Ligand binding site; other site 290340002069 Putative Catalytic site; other site 290340002070 DXD motif; other site 290340002071 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 290340002072 catalytic residue [active] 290340002073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290340002074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340002075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340002076 dimer interface [polypeptide binding]; other site 290340002077 phosphorylation site [posttranslational modification] 290340002078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340002079 ATP binding site [chemical binding]; other site 290340002080 Mg2+ binding site [ion binding]; other site 290340002081 G-X-G motif; other site 290340002082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002084 active site 290340002085 phosphorylation site [posttranslational modification] 290340002086 intermolecular recognition site; other site 290340002087 dimerization interface [polypeptide binding]; other site 290340002088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002089 DNA binding site [nucleotide binding] 290340002090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002091 DNA binding site [nucleotide binding] 290340002092 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002093 catalytic core [active] 290340002094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340002095 Helix-turn-helix domains; Region: HTH; cl00088 290340002096 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340002097 putative dimerization interface [polypeptide binding]; other site 290340002098 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 290340002099 EamA-like transporter family; Region: EamA; cl01037 290340002100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340002101 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340002102 tetrameric interface [polypeptide binding]; other site 290340002103 NAD binding site [chemical binding]; other site 290340002104 catalytic residues [active] 290340002105 substrate binding site [chemical binding]; other site 290340002106 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290340002107 Helix-turn-helix domains; Region: HTH; cl00088 290340002108 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290340002109 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340002110 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340002111 active site 290340002112 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340002113 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340002114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002116 dimer interface [polypeptide binding]; other site 290340002117 conserved gate region; other site 290340002118 ABC-ATPase subunit interface; other site 290340002119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340002120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002121 putative PBP binding loops; other site 290340002122 ABC-ATPase subunit interface; other site 290340002123 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340002124 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340002125 Walker A/P-loop; other site 290340002126 ATP binding site [chemical binding]; other site 290340002127 Q-loop/lid; other site 290340002128 ABC transporter signature motif; other site 290340002129 Walker B; other site 290340002130 D-loop; other site 290340002131 H-loop/switch region; other site 290340002132 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340002133 Walker A/P-loop; other site 290340002134 ATP binding site [chemical binding]; other site 290340002135 Q-loop/lid; other site 290340002136 ABC transporter signature motif; other site 290340002137 Walker B; other site 290340002138 D-loop; other site 290340002139 H-loop/switch region; other site 290340002140 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340002141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002142 FAD dependent oxidoreductase; Region: DAO; pfam01266 290340002143 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 290340002144 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 290340002145 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 290340002146 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340002147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002148 Walker A/P-loop; other site 290340002149 ATP binding site [chemical binding]; other site 290340002150 Q-loop/lid; other site 290340002151 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 290340002152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340002153 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340002154 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290340002155 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340002156 active site residue [active] 290340002157 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340002158 active site residue [active] 290340002159 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 290340002160 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 290340002161 putative active site cavity [active] 290340002162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340002163 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340002164 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340002165 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340002166 inhibitor site; inhibition site 290340002167 active site 290340002168 dimer interface [polypeptide binding]; other site 290340002169 catalytic residue [active] 290340002170 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290340002171 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340002172 Walker A/P-loop; other site 290340002173 ATP binding site [chemical binding]; other site 290340002174 Q-loop/lid; other site 290340002175 ABC transporter signature motif; other site 290340002176 Walker B; other site 290340002177 D-loop; other site 290340002178 H-loop/switch region; other site 290340002179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340002180 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290340002181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002182 dimer interface [polypeptide binding]; other site 290340002183 conserved gate region; other site 290340002184 putative PBP binding loops; other site 290340002185 ABC-ATPase subunit interface; other site 290340002186 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290340002187 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340002188 Walker A/P-loop; other site 290340002189 ATP binding site [chemical binding]; other site 290340002190 Q-loop/lid; other site 290340002191 ABC transporter signature motif; other site 290340002192 Walker B; other site 290340002193 D-loop; other site 290340002194 H-loop/switch region; other site 290340002195 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340002196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340002197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002198 dimer interface [polypeptide binding]; other site 290340002199 conserved gate region; other site 290340002200 putative PBP binding loops; other site 290340002201 ABC-ATPase subunit interface; other site 290340002202 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340002203 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340002204 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340002205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002206 DNA-binding site [nucleotide binding]; DNA binding site 290340002207 FCD domain; Region: FCD; cl11656 290340002208 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 290340002209 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 290340002210 active site 290340002211 substrate-binding site [chemical binding]; other site 290340002212 metal-binding site [ion binding] 290340002213 GTP binding site [chemical binding]; other site 290340002214 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 290340002215 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 290340002216 heme-binding site [chemical binding]; other site 290340002217 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 290340002218 FAD binding pocket [chemical binding]; other site 290340002219 FAD binding motif [chemical binding]; other site 290340002220 phosphate binding motif [ion binding]; other site 290340002221 beta-alpha-beta structure motif; other site 290340002222 NAD binding pocket [chemical binding]; other site 290340002223 Heme binding pocket [chemical binding]; other site 290340002224 Helix-turn-helix domains; Region: HTH; cl00088 290340002225 Rrf2 family protein; Region: rrf2_super; TIGR00738 290340002226 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 290340002227 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290340002228 active site 290340002229 substrate binding site [chemical binding]; other site 290340002230 metal binding site [ion binding]; metal-binding site 290340002231 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 290340002232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002233 ATP binding site [chemical binding]; other site 290340002234 putative Mg++ binding site [ion binding]; other site 290340002235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002236 nucleotide binding region [chemical binding]; other site 290340002237 ATP-binding site [chemical binding]; other site 290340002238 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 290340002239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340002240 active site 290340002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340002243 putative substrate translocation pore; other site 290340002244 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 290340002245 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340002246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002247 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290340002248 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 290340002249 Lamin Tail Domain; Region: LTD; pfam00932 290340002250 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 290340002251 generic binding surface I; other site 290340002252 generic binding surface II; other site 290340002253 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 290340002254 putative active site [active] 290340002255 putative catalytic site [active] 290340002256 putative Mg binding site IVb [ion binding]; other site 290340002257 putative phosphate binding site [ion binding]; other site 290340002258 putative DNA binding site [nucleotide binding]; other site 290340002259 putative Mg binding site IVa [ion binding]; other site 290340002260 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 290340002261 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 290340002262 putative active site [active] 290340002263 putative metal binding site [ion binding]; other site 290340002264 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290340002265 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340002266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002267 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340002268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002269 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 290340002270 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 290340002271 NAD(P) binding site [chemical binding]; other site 290340002272 Helix-turn-helix domains; Region: HTH; cl00088 290340002273 carbon starvation protein A; Provisional; Region: PRK15015 290340002274 Carbon starvation protein CstA; Region: CstA; pfam02554 290340002275 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290340002276 Protein of unknown function (DUF466); Region: DUF466; cl01082 290340002277 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 290340002278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340002279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340002280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340002281 active site 290340002282 catalytic tetrad [active] 290340002283 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340002284 Helix-turn-helix domains; Region: HTH; cl00088 290340002285 Helix-turn-helix domains; Region: HTH; cl00088 290340002286 amidase; Provisional; Region: PRK07486 290340002287 Amidase; Region: Amidase; cl11426 290340002288 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340002289 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 290340002290 metal binding site [ion binding]; metal-binding site 290340002291 putative dimer interface [polypeptide binding]; other site 290340002292 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 290340002293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340002294 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340002295 tetramerization interface [polypeptide binding]; other site 290340002296 NAD(P) binding site [chemical binding]; other site 290340002297 catalytic residues [active] 290340002298 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340002299 TPP-binding site [chemical binding]; other site 290340002300 dimer interface [polypeptide binding]; other site 290340002301 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340002302 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340002303 PYR/PP interface [polypeptide binding]; other site 290340002304 dimer interface [polypeptide binding]; other site 290340002305 TPP binding site [chemical binding]; other site 290340002306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340002307 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340002308 putative substrate binding site [chemical binding]; other site 290340002309 putative ATP binding site [chemical binding]; other site 290340002310 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290340002311 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 290340002312 NAD(P) binding site [chemical binding]; other site 290340002313 active site 290340002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002315 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340002316 NAD(P) binding site [chemical binding]; other site 290340002317 active site 290340002318 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 290340002319 short chain dehydrogenase; Provisional; Region: PRK06523 290340002320 classical (c) SDRs; Region: SDR_c; cd05233 290340002321 NAD(P) binding site [chemical binding]; other site 290340002322 active site 290340002323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002324 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340002325 NAD(P) binding site [chemical binding]; other site 290340002326 active site 290340002327 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290340002328 Helix-turn-helix domains; Region: HTH; cl00088 290340002329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340002330 dimerization interface [polypeptide binding]; other site 290340002331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340002332 NifU-like domain; Region: NifU; cl00484 290340002333 short chain dehydrogenase; Provisional; Region: PRK06114 290340002334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002335 NAD(P) binding site [chemical binding]; other site 290340002336 active site 290340002337 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340002338 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340002339 ligand binding site [chemical binding]; other site 290340002340 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340002341 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340002342 Walker A/P-loop; other site 290340002343 ATP binding site [chemical binding]; other site 290340002344 Q-loop/lid; other site 290340002345 ABC transporter signature motif; other site 290340002346 Walker B; other site 290340002347 D-loop; other site 290340002348 H-loop/switch region; other site 290340002349 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340002350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340002351 TM-ABC transporter signature motif; other site 290340002352 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 290340002353 classical (c) SDRs; Region: SDR_c; cd05233 290340002354 NAD(P) binding site [chemical binding]; other site 290340002355 active site 290340002356 short chain dehydrogenase; Provisional; Region: PRK06523 290340002357 classical (c) SDRs; Region: SDR_c; cd05233 290340002358 NAD(P) binding site [chemical binding]; other site 290340002359 active site 290340002360 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 290340002361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340002362 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002364 putative substrate translocation pore; other site 290340002365 Helix-turn-helix domains; Region: HTH; cl00088 290340002366 GAF domain; Region: GAF; cl15785 290340002367 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340002368 Helix-turn-helix domains; Region: HTH; cl00088 290340002369 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290340002370 potential catalytic triad [active] 290340002371 conserved cys residue [active] 290340002372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340002373 Helix-turn-helix domains; Region: HTH; cl00088 290340002374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340002375 dimerization interface [polypeptide binding]; other site 290340002376 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 290340002377 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340002378 motif II; other site 290340002379 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340002380 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340002381 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340002382 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340002383 DNA polymerase III subunit delta'; Validated; Region: PRK07940 290340002384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002385 thymidylate kinase; Validated; Region: tmk; PRK00698 290340002386 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290340002387 TMP-binding site; other site 290340002388 ATP-binding site [chemical binding]; other site 290340002389 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 290340002390 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002391 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002392 catalytic residue [active] 290340002393 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 290340002394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002395 catalytic core [active] 290340002396 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 290340002397 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290340002398 PhoU domain; Region: PhoU; pfam01895 290340002399 PhoU domain; Region: PhoU; pfam01895 290340002400 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 290340002401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340002402 dimer interface [polypeptide binding]; other site 290340002403 phosphorylation site [posttranslational modification] 290340002404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340002405 ATP binding site [chemical binding]; other site 290340002406 Mg2+ binding site [ion binding]; other site 290340002407 G-X-G motif; other site 290340002408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002410 active site 290340002411 phosphorylation site [posttranslational modification] 290340002412 intermolecular recognition site; other site 290340002413 dimerization interface [polypeptide binding]; other site 290340002414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002415 DNA binding site [nucleotide binding] 290340002416 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 290340002417 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290340002418 substrate binding site; other site 290340002419 dimer interface; other site 290340002420 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 290340002421 homotrimer interaction site [polypeptide binding]; other site 290340002422 zinc binding site [ion binding]; other site 290340002423 CDP-binding sites; other site 290340002424 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290340002425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340002426 active site 290340002427 HIGH motif; other site 290340002428 nucleotide binding site [chemical binding]; other site 290340002429 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290340002430 active site 290340002431 HIGH motif; other site 290340002432 KMSKS motif; other site 290340002433 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290340002434 tRNA binding surface [nucleotide binding]; other site 290340002435 anticodon binding site; other site 290340002436 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 290340002437 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 290340002438 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290340002439 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340002440 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290340002441 putative active site [active] 290340002442 catalytic triad [active] 290340002443 putative dimer interface [polypeptide binding]; other site 290340002444 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290340002445 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290340002446 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290340002447 active site 290340002448 catalytic site [active] 290340002449 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 290340002450 active site 290340002451 barstar interaction site; other site 290340002452 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 290340002453 putative RNAase interaction site [polypeptide binding]; other site 290340002454 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 290340002455 putative homodimer interface [polypeptide binding]; other site 290340002456 putative active site pocket [active] 290340002457 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 290340002458 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 290340002459 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 290340002460 active site 290340002461 homodimer interface [polypeptide binding]; other site 290340002462 catalytic site [active] 290340002463 acceptor binding site [chemical binding]; other site 290340002464 trehalose synthase; Region: treS_nterm; TIGR02456 290340002465 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290340002466 active site 290340002467 catalytic site [active] 290340002468 glycogen branching enzyme; Provisional; Region: PRK14705 290340002469 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 290340002470 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 290340002471 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 290340002472 active site 290340002473 catalytic site [active] 290340002474 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 290340002475 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 290340002476 putative hydrophobic ligand binding site [chemical binding]; other site 290340002477 CLM binding site; other site 290340002478 L1 loop; other site 290340002479 DNA binding site [nucleotide binding] 290340002480 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340002481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340002482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340002483 DNA binding site [nucleotide binding] 290340002484 domain linker motif; other site 290340002485 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340002486 dimerization interface [polypeptide binding]; other site 290340002487 ligand binding site [chemical binding]; other site 290340002488 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290340002489 active site 290340002490 catalytic site [active] 290340002491 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 290340002492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340002493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002494 dimer interface [polypeptide binding]; other site 290340002495 conserved gate region; other site 290340002496 ABC-ATPase subunit interface; other site 290340002497 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 290340002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002499 dimer interface [polypeptide binding]; other site 290340002500 conserved gate region; other site 290340002501 putative PBP binding loops; other site 290340002502 ABC-ATPase subunit interface; other site 290340002503 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 290340002504 homodimer interface [polypeptide binding]; other site 290340002505 maltodextrin glucosidase; Provisional; Region: PRK10785 290340002506 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 290340002507 active site 290340002508 homodimer interface [polypeptide binding]; other site 290340002509 catalytic site [active] 290340002510 FAD binding domain; Region: FAD_binding_4; pfam01565 290340002511 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 290340002512 cyanate transporter; Region: CynX; TIGR00896 290340002513 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290340002514 cytosine deaminase; Provisional; Region: PRK05985 290340002515 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340002516 active site 290340002517 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340002518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002519 DNA-binding site [nucleotide binding]; DNA binding site 290340002520 FCD domain; Region: FCD; cl11656 290340002521 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 290340002522 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 290340002523 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 290340002524 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 290340002525 active site 290340002526 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290340002527 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 290340002528 Walker A/P-loop; other site 290340002529 ATP binding site [chemical binding]; other site 290340002530 Q-loop/lid; other site 290340002531 ABC transporter signature motif; other site 290340002532 Walker B; other site 290340002533 D-loop; other site 290340002534 H-loop/switch region; other site 290340002535 TOBE domain; Region: TOBE_2; cl01440 290340002536 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 290340002537 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340002538 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 290340002539 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 290340002540 active site 290340002541 homotetramer interface [polypeptide binding]; other site 290340002542 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340002543 Helix-turn-helix domains; Region: HTH; cl00088 290340002544 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290340002545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002546 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290340002547 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 290340002548 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 290340002549 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340002550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340002551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340002552 DNA binding site [nucleotide binding] 290340002553 domain linker motif; other site 290340002554 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340002555 putative ligand binding site [chemical binding]; other site 290340002556 putative dimerization interface [polypeptide binding]; other site 290340002557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002559 dimer interface [polypeptide binding]; other site 290340002560 conserved gate region; other site 290340002561 putative PBP binding loops; other site 290340002562 ABC-ATPase subunit interface; other site 290340002563 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340002564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002565 dimer interface [polypeptide binding]; other site 290340002566 conserved gate region; other site 290340002567 putative PBP binding loops; other site 290340002568 ABC-ATPase subunit interface; other site 290340002569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340002570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340002571 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 290340002572 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 290340002573 active site 290340002574 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340002575 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340002576 substrate binding [chemical binding]; other site 290340002577 active site 290340002578 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340002579 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340002580 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340002581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002582 ATP binding site [chemical binding]; other site 290340002583 putative Mg++ binding site [ion binding]; other site 290340002584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002585 nucleotide binding region [chemical binding]; other site 290340002586 ATP-binding site [chemical binding]; other site 290340002587 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 290340002588 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290340002589 putative substrate binding site [chemical binding]; other site 290340002590 putative ATP binding site [chemical binding]; other site 290340002591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002592 catalytic core [active] 290340002593 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290340002594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340002596 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340002597 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 290340002598 Protein of unknown function DUF72; Region: DUF72; cl00777 290340002599 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340002600 Helix-turn-helix domains; Region: HTH; cl00088 290340002601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340002602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002603 NAD(P) binding site [chemical binding]; other site 290340002604 active site 290340002605 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 290340002606 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 290340002607 active site 290340002608 acyl-coenzyme A oxidase; Region: PLN02526 290340002609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340002610 active site 290340002611 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 290340002612 putative active site [active] 290340002613 putative catalytic site [active] 290340002614 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340002615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002616 putative substrate translocation pore; other site 290340002617 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 290340002618 AMP-binding enzyme; Region: AMP-binding; cl15778 290340002619 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340002620 Protein of unknown function (DUF805); Region: DUF805; cl01224 290340002621 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002623 CAAX protease self-immunity; Region: Abi; cl00558 290340002624 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340002625 Spore germination protein; Region: Spore_permease; cl15802 290340002626 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 290340002627 agmatine deiminase; Region: agmatine_aguA; TIGR03380 290340002628 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340002629 active site 290340002630 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340002631 active site 290340002632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340002633 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340002634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002635 non-specific DNA binding site [nucleotide binding]; other site 290340002636 salt bridge; other site 290340002637 sequence-specific DNA binding site [nucleotide binding]; other site 290340002638 Cupin domain; Region: Cupin_2; cl09118 290340002639 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290340002640 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340002641 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 290340002642 metal binding site [ion binding]; metal-binding site 290340002643 putative dimer interface [polypeptide binding]; other site 290340002644 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 290340002645 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 290340002646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002647 putative substrate translocation pore; other site 290340002648 Helix-turn-helix domains; Region: HTH; cl00088 290340002649 glycine dehydrogenase; Provisional; Region: PRK05367 290340002650 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340002651 tetramer interface [polypeptide binding]; other site 290340002652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002653 catalytic residue [active] 290340002654 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340002655 tetramer interface [polypeptide binding]; other site 290340002656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002657 catalytic residue [active] 290340002658 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290340002659 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340002660 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340002661 lipoyl attachment site [posttranslational modification]; other site 290340002662 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340002663 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340002664 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 290340002665 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 290340002666 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 290340002667 active site 290340002668 substrate binding site [chemical binding]; other site 290340002669 Mg2+ binding site [ion binding]; other site 290340002670 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340002671 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340002672 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340002673 Uncharacterized conserved protein [Function unknown]; Region: COG2966 290340002674 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 290340002675 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340002676 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340002677 FAD binding pocket [chemical binding]; other site 290340002678 FAD binding motif [chemical binding]; other site 290340002679 phosphate binding motif [ion binding]; other site 290340002680 NAD binding pocket [chemical binding]; other site 290340002681 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 290340002682 ligand binding site [chemical binding]; other site 290340002683 active site 290340002684 UGI interface [polypeptide binding]; other site 290340002685 catalytic site [active] 290340002686 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 290340002687 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340002688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290340002689 DNA-binding site [nucleotide binding]; DNA binding site 290340002690 RNA-binding motif; other site 290340002691 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290340002692 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290340002693 ring oligomerisation interface [polypeptide binding]; other site 290340002694 ATP/Mg binding site [chemical binding]; other site 290340002695 stacking interactions; other site 290340002696 hinge regions; other site 290340002697 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290340002698 RNA/DNA hybrid binding site [nucleotide binding]; other site 290340002699 active site 290340002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 290340002701 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290340002702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002704 active site 290340002705 phosphorylation site [posttranslational modification] 290340002706 intermolecular recognition site; other site 290340002707 dimerization interface [polypeptide binding]; other site 290340002708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002709 DNA binding site [nucleotide binding] 290340002710 LysE type translocator; Region: LysE; cl00565 290340002711 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 290340002712 Helix-turn-helix domains; Region: HTH; cl00088 290340002713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340002714 dimerization interface [polypeptide binding]; other site 290340002715 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340002716 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340002717 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340002718 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290340002719 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290340002720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002722 ATP binding site [chemical binding]; other site 290340002723 putative Mg++ binding site [ion binding]; other site 290340002724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002725 nucleotide binding region [chemical binding]; other site 290340002726 ATP-binding site [chemical binding]; other site 290340002727 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290340002728 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290340002729 DNA-binding site [nucleotide binding]; DNA binding site 290340002730 RNA-binding motif; other site 290340002731 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 290340002732 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340002733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002734 putative substrate translocation pore; other site 290340002735 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 290340002736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002738 catalytic residue [active] 290340002739 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002740 Helix-turn-helix domains; Region: HTH; cl00088 290340002741 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340002742 FeoA domain; Region: FeoA; cl00838 290340002743 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340002744 NlpC/P60 family; Region: NLPC_P60; cl11438 290340002745 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340002746 active site 290340002747 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290340002748 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 290340002749 GTP binding site; other site 290340002750 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340002751 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340002752 dimer interface [polypeptide binding]; other site 290340002753 putative functional site; other site 290340002754 putative MPT binding site; other site 290340002755 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340002756 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340002757 putative molybdopterin cofactor binding site [chemical binding]; other site 290340002758 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340002759 putative molybdopterin cofactor binding site; other site 290340002760 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 290340002761 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 290340002762 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 290340002763 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 290340002764 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340002765 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340002766 Walker A/P-loop; other site 290340002767 ATP binding site [chemical binding]; other site 290340002768 Q-loop/lid; other site 290340002769 ABC transporter signature motif; other site 290340002770 Walker B; other site 290340002771 D-loop; other site 290340002772 H-loop/switch region; other site 290340002773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002774 dimer interface [polypeptide binding]; other site 290340002775 conserved gate region; other site 290340002776 putative PBP binding loops; other site 290340002777 ABC-ATPase subunit interface; other site 290340002778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340002779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340002780 substrate binding pocket [chemical binding]; other site 290340002781 membrane-bound complex binding site; other site 290340002782 hinge residues; other site 290340002783 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340002784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002785 Walker A/P-loop; other site 290340002786 ATP binding site [chemical binding]; other site 290340002787 Q-loop/lid; other site 290340002788 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340002789 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340002790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002791 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340002792 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002793 Walker A/P-loop; other site 290340002794 ATP binding site [chemical binding]; other site 290340002795 Q-loop/lid; other site 290340002796 ABC transporter signature motif; other site 290340002797 Walker B; other site 290340002798 D-loop; other site 290340002799 H-loop/switch region; other site 290340002800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 290340002801 nudix motif; other site 290340002802 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 290340002803 active site 290340002804 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 290340002805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002806 Family description; Region: UvrD_C_2; cl15862 290340002807 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290340002808 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340002809 CoA-ligase; Region: Ligase_CoA; cl02894 290340002810 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290340002811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002813 CoA-ligase; Region: Ligase_CoA; cl02894 290340002814 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340002815 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 290340002816 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340002817 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340002818 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340002819 FG-GAP repeat; Region: FG-GAP; cl15299 290340002820 Family description; Region: VCBS; pfam13517 290340002821 Family description; Region: VCBS; pfam13517 290340002822 Family description; Region: VCBS; pfam13517 290340002823 FG-GAP repeat; Region: FG-GAP; cl15299 290340002824 Family description; Region: VCBS; pfam13517 290340002825 Family description; Region: VCBS; pfam13517 290340002826 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340002827 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340002828 catalytic triad [active] 290340002829 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290340002830 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 290340002831 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290340002832 diiron binding motif [ion binding]; other site 290340002833 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 290340002834 Sodium:solute symporter family; Region: SSF; cl00456 290340002835 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340002836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002837 non-specific DNA binding site [nucleotide binding]; other site 290340002838 salt bridge; other site 290340002839 sequence-specific DNA binding site [nucleotide binding]; other site 290340002840 Cupin domain; Region: Cupin_2; cl09118 290340002841 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340002842 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340002843 Amino acid permease; Region: AA_permease_2; pfam13520 290340002844 Arginase family; Region: Arginase; cl00306 290340002845 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290340002846 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340002847 PYR/PP interface [polypeptide binding]; other site 290340002848 dimer interface [polypeptide binding]; other site 290340002849 TPP binding site [chemical binding]; other site 290340002850 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340002851 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340002852 TPP-binding site [chemical binding]; other site 290340002853 Helix-turn-helix domains; Region: HTH; cl00088 290340002854 transcriptional regulator SlyA; Provisional; Region: PRK03573 290340002855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340002856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002857 putative substrate translocation pore; other site 290340002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002860 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340002861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002862 Walker A/P-loop; other site 290340002863 ATP binding site [chemical binding]; other site 290340002864 Q-loop/lid; other site 290340002865 ABC transporter signature motif; other site 290340002866 Walker B; other site 290340002867 D-loop; other site 290340002868 H-loop/switch region; other site 290340002869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002870 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340002871 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 290340002872 Walker A/P-loop; other site 290340002873 ATP binding site [chemical binding]; other site 290340002874 Q-loop/lid; other site 290340002875 ABC transporter signature motif; other site 290340002876 Walker B; other site 290340002877 D-loop; other site 290340002878 H-loop/switch region; other site 290340002879 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340002880 active site 290340002881 CutC family; Region: CutC; cl01218 290340002882 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 290340002883 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 290340002884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340002885 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340002886 Walker A motif; other site 290340002887 ATP binding site [chemical binding]; other site 290340002888 Walker B motif; other site 290340002889 arginine finger; other site 290340002890 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 290340002891 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340002892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 290340002893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340002894 dimer interface [polypeptide binding]; other site 290340002895 phosphorylation site [posttranslational modification] 290340002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340002897 ATP binding site [chemical binding]; other site 290340002898 Mg2+ binding site [ion binding]; other site 290340002899 G-X-G motif; other site 290340002900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002902 active site 290340002903 phosphorylation site [posttranslational modification] 290340002904 intermolecular recognition site; other site 290340002905 dimerization interface [polypeptide binding]; other site 290340002906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002907 DNA binding site [nucleotide binding] 290340002908 Ferredoxin [Energy production and conversion]; Region: COG1146 290340002909 4Fe-4S binding domain; Region: Fer4; cl02805 290340002910 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340002911 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340002912 NAD(P) binding site [chemical binding]; other site 290340002913 catalytic residues [active] 290340002914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002915 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340002916 NAD(P) binding site [chemical binding]; other site 290340002917 active site 290340002918 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340002919 inhibitor site; inhibition site 290340002920 active site 290340002921 dimer interface [polypeptide binding]; other site 290340002922 catalytic residue [active] 290340002923 enoyl-CoA hydratase; Provisional; Region: PRK06494 290340002924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340002925 substrate binding site [chemical binding]; other site 290340002926 oxyanion hole (OAH) forming residues; other site 290340002927 trimer interface [polypeptide binding]; other site 290340002928 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340002929 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340002930 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 290340002931 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340002932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002933 putative substrate translocation pore; other site 290340002934 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340002935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002936 salt bridge; other site 290340002937 non-specific DNA binding site [nucleotide binding]; other site 290340002938 sequence-specific DNA binding site [nucleotide binding]; other site 290340002939 Cupin domain; Region: Cupin_2; cl09118 290340002940 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290340002941 mismatch recognition site; other site 290340002942 additional DNA contacts [nucleotide binding]; other site 290340002943 active site 290340002944 zinc binding site [ion binding]; other site 290340002945 DNA intercalation site [nucleotide binding]; other site 290340002946 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 290340002947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340002948 AAA domain; Region: AAA_26; pfam13500 290340002949 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290340002950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002951 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002952 catalytic residue [active] 290340002953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340002954 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 290340002955 inhibitor-cofactor binding pocket; inhibition site 290340002956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002957 catalytic residue [active] 290340002958 biotin synthase; Validated; Region: PRK06256 290340002959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340002960 FeS/SAM binding site; other site 290340002961 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 290340002962 Sodium:solute symporter family; Region: SSF; cl00456 290340002963 CsbD-like; Region: CsbD; cl15799 290340002964 oxidoreductase; Provisional; Region: PRK06128 290340002965 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290340002966 NAD binding site [chemical binding]; other site 290340002967 metal binding site [ion binding]; metal-binding site 290340002968 active site 290340002969 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290340002970 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340002971 NAD binding site [chemical binding]; other site 290340002972 catalytic Zn binding site [ion binding]; other site 290340002973 structural Zn binding site [ion binding]; other site 290340002974 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340002975 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290340002976 FMN binding site [chemical binding]; other site 290340002977 active site 290340002978 substrate binding site [chemical binding]; other site 290340002979 catalytic residue [active] 290340002980 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340002981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002982 DNA-binding site [nucleotide binding]; DNA binding site 290340002983 FCD domain; Region: FCD; cl11656 290340002984 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340002985 dihydroxyacetone kinase; Provisional; Region: PRK14479 290340002986 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290340002987 DAK2 domain; Region: Dak2; cl03685 290340002988 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 290340002989 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 290340002990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002991 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340002992 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340002993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002994 NAD(P) binding site [chemical binding]; other site 290340002995 active site 290340002996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340002998 putative substrate translocation pore; other site 290340002999 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290340003000 substrate binding site [chemical binding]; other site 290340003001 dimer interface [polypeptide binding]; other site 290340003002 catalytic triad [active] 290340003003 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 290340003004 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 290340003005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003006 Family description; Region: UvrD_C_2; cl15862 290340003007 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340003008 nucleoside/Zn binding site; other site 290340003009 dimer interface [polypeptide binding]; other site 290340003010 catalytic motif [active] 290340003011 FOG: CBS domain [General function prediction only]; Region: COG0517 290340003012 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 290340003013 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 290340003014 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 290340003015 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 290340003016 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 290340003017 RNA binding site [nucleotide binding]; other site 290340003018 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290340003019 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 290340003020 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290340003021 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 290340003022 active site 290340003023 purine riboside binding site [chemical binding]; other site 290340003024 Acylphosphatase; Region: Acylphosphatase; cl00551 290340003025 Helix-turn-helix domains; Region: HTH; cl00088 290340003026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003027 NAD(P) binding site [chemical binding]; other site 290340003028 active site 290340003029 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290340003030 substrate binding site [chemical binding]; other site 290340003031 dimer interface [polypeptide binding]; other site 290340003032 ATP binding site [chemical binding]; other site 290340003033 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340003034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340003035 DNA-binding site [nucleotide binding]; DNA binding site 290340003036 UTRA domain; Region: UTRA; cl01230 290340003037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003038 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340003039 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 290340003040 active site 290340003041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003042 dimerization interface [polypeptide binding]; other site 290340003043 putative DNA binding site [nucleotide binding]; other site 290340003044 putative Zn2+ binding site [ion binding]; other site 290340003045 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 290340003046 putative hydrophobic ligand binding site [chemical binding]; other site 290340003047 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340003048 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 290340003049 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340003050 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340003051 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003053 dimer interface [polypeptide binding]; other site 290340003054 conserved gate region; other site 290340003055 ABC-ATPase subunit interface; other site 290340003056 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340003057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003058 dimer interface [polypeptide binding]; other site 290340003059 ABC-ATPase subunit interface; other site 290340003060 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340003061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340003062 Protein of unknown function, DUF624; Region: DUF624; cl02369 290340003063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340003064 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290340003065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340003066 active site 290340003067 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340003068 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340003069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340003070 active site 290340003071 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 290340003072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003073 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 290340003074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340003075 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340003076 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 290340003077 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340003078 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340003079 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340003080 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340003081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003082 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340003083 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340003084 Cupin domain; Region: Cupin_2; cl09118 290340003085 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003087 DNA binding site [nucleotide binding] 290340003088 domain linker motif; other site 290340003089 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340003090 putative dimerization interface [polypeptide binding]; other site 290340003091 putative ligand binding site [chemical binding]; other site 290340003092 GAF domain; Region: GAF; cl15785 290340003093 ANTAR domain; Region: ANTAR; cl04297 290340003094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003096 putative substrate translocation pore; other site 290340003097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340003099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340003100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340003101 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 290340003102 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290340003103 putative NAD(P) binding site [chemical binding]; other site 290340003104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340003105 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 290340003106 Helix-turn-helix domains; Region: HTH; cl00088 290340003107 Integral membrane protein TerC family; Region: TerC; cl10468 290340003108 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 290340003109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003110 dimerization interface [polypeptide binding]; other site 290340003111 putative DNA binding site [nucleotide binding]; other site 290340003112 putative Zn2+ binding site [ion binding]; other site 290340003113 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 290340003114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340003115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340003116 Helix-turn-helix domains; Region: HTH; cl00088 290340003117 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290340003118 EamA-like transporter family; Region: EamA; cl01037 290340003119 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 290340003120 Z1 domain; Region: Z1; pfam10593 290340003121 Protein of unknown function DUF262; Region: DUF262; cl14890 290340003122 amino acid transporter; Region: 2A0306; TIGR00909 290340003123 Spore germination protein; Region: Spore_permease; cl15802 290340003124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003125 NAD(P) binding site [chemical binding]; other site 290340003126 active site 290340003127 TfoX N-terminal domain; Region: TfoX_N; cl01167 290340003128 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 290340003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003130 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 290340003131 putative active site [active] 290340003132 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290340003133 DNA-binding site [nucleotide binding]; DNA binding site 290340003134 RNA-binding motif; other site 290340003135 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 290340003136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003137 Walker A/P-loop; other site 290340003138 ATP binding site [chemical binding]; other site 290340003139 Q-loop/lid; other site 290340003140 ABC transporter signature motif; other site 290340003141 Walker B; other site 290340003142 D-loop; other site 290340003143 H-loop/switch region; other site 290340003144 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 290340003145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003146 DNA binding residues [nucleotide binding] 290340003147 dimerization interface [polypeptide binding]; other site 290340003148 amino acid transporter; Region: 2A0306; TIGR00909 290340003149 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340003150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003151 multidrug resistance protein MdtH; Provisional; Region: PRK11646 290340003152 putative substrate translocation pore; other site 290340003153 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340003154 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340003159 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 290340003160 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 290340003161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003162 AAA domain; Region: AAA_21; pfam13304 290340003163 Walker A/P-loop; other site 290340003164 ATP binding site [chemical binding]; other site 290340003165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003166 Q-loop/lid; other site 290340003167 ABC transporter signature motif; other site 290340003168 Walker B; other site 290340003169 D-loop; other site 290340003170 H-loop/switch region; other site 290340003171 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 290340003172 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340003173 DNA binding residues [nucleotide binding] 290340003174 putative dimer interface [polypeptide binding]; other site 290340003175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290340003176 putative dimer interface [polypeptide binding]; other site 290340003177 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340003178 HSP70 interaction site [polypeptide binding]; other site 290340003179 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340003180 putative dimer interface [polypeptide binding]; other site 290340003181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003182 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340003183 putative dimer interface [polypeptide binding]; other site 290340003184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003185 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290340003186 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290340003187 active site 290340003188 substrate binding site [chemical binding]; other site 290340003189 cosubstrate binding site; other site 290340003190 catalytic site [active] 290340003191 benzoate transport; Region: 2A0115; TIGR00895 290340003192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003193 putative substrate translocation pore; other site 290340003194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003195 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 290340003196 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 290340003197 putative active site [active] 290340003198 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340003199 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340003200 putative active site [active] 290340003201 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290340003202 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290340003203 purine monophosphate binding site [chemical binding]; other site 290340003204 dimer interface [polypeptide binding]; other site 290340003205 putative catalytic residues [active] 290340003206 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290340003207 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340003208 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 290340003209 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 290340003210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003211 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 290340003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003213 dimer interface [polypeptide binding]; other site 290340003214 conserved gate region; other site 290340003215 ABC-ATPase subunit interface; other site 290340003216 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 290340003217 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 290340003218 Walker A/P-loop; other site 290340003219 ATP binding site [chemical binding]; other site 290340003220 Q-loop/lid; other site 290340003221 ABC transporter signature motif; other site 290340003222 Walker B; other site 290340003223 D-loop; other site 290340003224 H-loop/switch region; other site 290340003225 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 290340003226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340003227 substrate binding pocket [chemical binding]; other site 290340003228 membrane-bound complex binding site; other site 290340003229 hinge residues; other site 290340003230 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 290340003231 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340003232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340003233 DNA-binding site [nucleotide binding]; DNA binding site 290340003234 UTRA domain; Region: UTRA; cl01230 290340003235 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 290340003236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340003237 motif II; other site 290340003238 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340003239 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340003240 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290340003241 Walker A/P-loop; other site 290340003242 ATP binding site [chemical binding]; other site 290340003243 Q-loop/lid; other site 290340003244 ABC transporter signature motif; other site 290340003245 Walker B; other site 290340003246 D-loop; other site 290340003247 H-loop/switch region; other site 290340003248 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340003249 FtsX-like permease family; Region: FtsX; cl15850 290340003250 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 290340003251 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290340003252 putative ligand binding site [chemical binding]; other site 290340003253 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340003254 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340003255 TM-ABC transporter signature motif; other site 290340003256 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 290340003257 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340003258 Walker A/P-loop; other site 290340003259 ATP binding site [chemical binding]; other site 290340003260 Q-loop/lid; other site 290340003261 ABC transporter signature motif; other site 290340003262 Walker B; other site 290340003263 D-loop; other site 290340003264 H-loop/switch region; other site 290340003265 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340003266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003267 dimerization interface [polypeptide binding]; other site 290340003268 putative DNA binding site [nucleotide binding]; other site 290340003269 putative Zn2+ binding site [ion binding]; other site 290340003270 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340003271 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340003272 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 290340003273 putative active site [active] 290340003274 catalytic triad [active] 290340003275 putative dimer interface [polypeptide binding]; other site 290340003276 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340003277 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340003278 Helix-turn-helix domains; Region: HTH; cl00088 290340003279 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290340003280 alanine racemase; Reviewed; Region: alr; PRK00053 290340003281 active site 290340003282 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340003283 dimer interface [polypeptide binding]; other site 290340003284 substrate binding site [chemical binding]; other site 290340003285 catalytic residues [active] 290340003286 amino acid transporter; Region: 2A0306; TIGR00909 290340003287 Spore germination protein; Region: Spore_permease; cl15802 290340003288 Spore germination protein; Region: Spore_permease; cl15802 290340003289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003290 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290340003291 Helix-turn-helix domains; Region: HTH; cl00088 290340003292 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290340003293 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290340003294 trimer interface [polypeptide binding]; other site 290340003295 putative metal binding site [ion binding]; other site 290340003296 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290340003297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003298 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340003299 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340003300 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340003301 putative active site [active] 290340003302 putative substrate binding site [chemical binding]; other site 290340003303 putative cosubstrate binding site; other site 290340003304 catalytic site [active] 290340003305 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340003306 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340003307 dimer interface [polypeptide binding]; other site 290340003308 active site 290340003309 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340003310 folate binding site [chemical binding]; other site 290340003311 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 290340003312 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290340003313 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290340003314 homodimer interface [polypeptide binding]; other site 290340003315 NADP binding site [chemical binding]; other site 290340003316 substrate binding site [chemical binding]; other site 290340003317 nodulation ABC transporter NodI; Provisional; Region: PRK13537 290340003318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003319 Walker A/P-loop; other site 290340003320 ATP binding site [chemical binding]; other site 290340003321 Q-loop/lid; other site 290340003322 ABC transporter signature motif; other site 290340003323 Walker B; other site 290340003324 D-loop; other site 290340003325 H-loop/switch region; other site 290340003326 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340003327 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340003328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003330 putative substrate translocation pore; other site 290340003331 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 290340003332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003334 DNA binding site [nucleotide binding] 290340003335 domain linker motif; other site 290340003336 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340003337 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 290340003338 putative active site [active] 290340003339 putative catalytic site [active] 290340003340 putative DNA binding site [nucleotide binding]; other site 290340003341 putative phosphate binding site [ion binding]; other site 290340003342 metal binding site A [ion binding]; metal-binding site 290340003343 putative AP binding site [nucleotide binding]; other site 290340003344 putative metal binding site B [ion binding]; other site 290340003345 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290340003346 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290340003347 active site 290340003348 HIGH motif; other site 290340003349 dimer interface [polypeptide binding]; other site 290340003350 KMSKS motif; other site 290340003351 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290340003352 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 290340003353 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 290340003354 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290340003355 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 290340003356 active site 290340003357 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340003358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340003359 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 290340003360 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290340003361 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 290340003362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003363 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340003364 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 290340003365 putative Iron-sulfur protein interface [polypeptide binding]; other site 290340003366 putative proximal heme binding site [chemical binding]; other site 290340003367 putative SdhC-like subunit interface [polypeptide binding]; other site 290340003368 putative distal heme binding site [chemical binding]; other site 290340003369 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 290340003370 putative Iron-sulfur protein interface [polypeptide binding]; other site 290340003371 putative proximal heme binding site [chemical binding]; other site 290340003372 putative SdhD-like interface [polypeptide binding]; other site 290340003373 putative distal heme binding site [chemical binding]; other site 290340003374 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 290340003375 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340003376 active site 290340003377 Cupin domain; Region: Cupin_2; cl09118 290340003378 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340003379 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 290340003380 metal binding site [ion binding]; metal-binding site 290340003381 putative dimer interface [polypeptide binding]; other site 290340003382 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340003383 Helix-turn-helix domains; Region: HTH; cl00088 290340003384 OsmC-like protein; Region: OsmC; cl00767 290340003385 Prostaglandin dehydrogenases; Region: PGDH; cd05288 290340003386 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 290340003387 NAD(P) binding site [chemical binding]; other site 290340003388 substrate binding site [chemical binding]; other site 290340003389 dimer interface [polypeptide binding]; other site 290340003390 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 290340003391 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 290340003392 ligand binding site [chemical binding]; other site 290340003393 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 290340003394 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340003395 Walker A/P-loop; other site 290340003396 ATP binding site [chemical binding]; other site 290340003397 Q-loop/lid; other site 290340003398 ABC transporter signature motif; other site 290340003399 Walker B; other site 290340003400 D-loop; other site 290340003401 H-loop/switch region; other site 290340003402 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340003403 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290340003404 TM-ABC transporter signature motif; other site 290340003405 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290340003406 TM-ABC transporter signature motif; other site 290340003407 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290340003408 active site 290340003409 catalytic motif [active] 290340003410 Zn binding site [ion binding]; other site 290340003411 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 290340003412 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290340003413 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290340003414 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 290340003415 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340003416 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340003417 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340003418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340003419 active site 290340003420 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 290340003421 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 290340003422 enolase; Provisional; Region: eno; PRK00077 290340003423 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290340003424 dimer interface [polypeptide binding]; other site 290340003425 metal binding site [ion binding]; metal-binding site 290340003426 substrate binding pocket [chemical binding]; other site 290340003427 Septum formation initiator; Region: DivIC; cl11433 290340003428 Protein of unknown function (DUF501); Region: DUF501; cl00652 290340003429 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 290340003430 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290340003431 active site 290340003432 catalytic residues [active] 290340003433 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290340003434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 290340003436 ACT domain; Region: ACT_3; pfam10000 290340003437 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290340003438 Predicted acetyltransferase [General function prediction only]; Region: COG3153 290340003439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340003440 Coenzyme A binding pocket [chemical binding]; other site 290340003441 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290340003442 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340003443 putative lipid kinase; Reviewed; Region: PRK13057 290340003444 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340003445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290340003446 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 290340003447 Walker A/P-loop; other site 290340003448 ATP binding site [chemical binding]; other site 290340003449 Q-loop/lid; other site 290340003450 ABC transporter signature motif; other site 290340003451 Walker B; other site 290340003452 D-loop; other site 290340003453 H-loop/switch region; other site 290340003454 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290340003455 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 290340003456 Walker A/P-loop; other site 290340003457 ATP binding site [chemical binding]; other site 290340003458 Q-loop/lid; other site 290340003459 ABC transporter signature motif; other site 290340003460 Walker B; other site 290340003461 D-loop; other site 290340003462 H-loop/switch region; other site 290340003463 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290340003464 TM-ABC transporter signature motif; other site 290340003465 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290340003466 TM-ABC transporter signature motif; other site 290340003467 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 290340003468 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 290340003469 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340003470 dimer interface [polypeptide binding]; other site 290340003471 active site 290340003472 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 290340003473 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 290340003474 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290340003475 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290340003476 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 290340003477 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 290340003478 dimer interface [polypeptide binding]; other site 290340003479 active site 290340003480 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 290340003481 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340003482 active site 290340003483 catalytic residues [active] 290340003484 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290340003485 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 290340003486 threonine dehydratase; Provisional; Region: PRK08198 290340003487 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290340003488 tetramer interface [polypeptide binding]; other site 290340003489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340003490 catalytic residue [active] 290340003491 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 290340003492 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290340003493 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290340003494 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290340003495 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 290340003496 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340003497 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 290340003498 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 290340003499 catalytic residues [active] 290340003500 Haemolysin-III related; Region: HlyIII; cl03831 290340003501 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 290340003502 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290340003503 catalytic residue [active] 290340003504 putative FPP diphosphate binding site; other site 290340003505 putative FPP binding hydrophobic cleft; other site 290340003506 dimer interface [polypeptide binding]; other site 290340003507 putative IPP diphosphate binding site; other site 290340003508 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 290340003509 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 290340003510 putative active site [active] 290340003511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003512 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340003513 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 290340003514 nudix motif; other site 290340003515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003517 putative substrate translocation pore; other site 290340003518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003519 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290340003520 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 290340003521 active sites [active] 290340003522 tetramer interface [polypeptide binding]; other site 290340003523 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 290340003524 active site clefts [active] 290340003525 zinc binding site [ion binding]; other site 290340003526 dimer interface [polypeptide binding]; other site 290340003527 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 290340003528 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290340003529 putative active site [active] 290340003530 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340003531 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 290340003532 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 290340003533 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 290340003534 AIR carboxylase; Region: AIRC; cl00310 290340003535 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 290340003536 LabA_like proteins; Region: LabA_like/DUF88; cl10034 290340003537 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340003538 GtrA-like protein; Region: GtrA; cl00971 290340003539 AMP-binding enzyme; Region: AMP-binding; cl15778 290340003540 Transcription factor WhiB; Region: Whib; pfam02467 290340003541 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340003542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340003543 active site 290340003544 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 290340003545 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 290340003546 Trm112p-like protein; Region: Trm112p; cl01066 290340003547 Adenosylhomocysteinase; Provisional; Region: PTZ00075 290340003548 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 290340003549 oligomerization interface [polypeptide binding]; other site 290340003550 active site 290340003551 NAD+ binding site [chemical binding]; other site 290340003552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 290340003553 Bacterial Ig-like domain; Region: Big_5; cl01012 290340003554 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 290340003555 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290340003556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290340003557 RDD family; Region: RDD; cl00746 290340003558 Integral membrane protein DUF95; Region: DUF95; cl00572 290340003559 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 290340003560 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 290340003561 putative active site [active] 290340003562 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340003563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340003564 catalytic residue [active] 290340003565 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 290340003566 EamA-like transporter family; Region: EamA; cl01037 290340003567 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290340003568 AMP-binding enzyme; Region: AMP-binding; cl15778 290340003569 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 290340003570 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 290340003571 Predicted methyltransferases [General function prediction only]; Region: COG0313 290340003572 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290340003573 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340003574 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340003575 tetramerization interface [polypeptide binding]; other site 290340003576 NAD(P) binding site [chemical binding]; other site 290340003577 catalytic residues [active] 290340003578 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 290340003579 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 290340003580 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340003581 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340003582 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340003583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340003584 Walker A motif; other site 290340003585 ATP binding site [chemical binding]; other site 290340003586 Walker B motif; other site 290340003587 arginine finger; other site 290340003588 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290340003589 active site 290340003590 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290340003591 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290340003592 G5 domain; Region: G5; pfam07501 290340003593 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 290340003594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003595 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 290340003596 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290340003597 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340003598 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340003599 ABC transporter; Region: ABC_tran_2; pfam12848 290340003600 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340003601 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290340003602 dimer interface [polypeptide binding]; other site 290340003603 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 290340003604 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290340003605 Substrate binding site; other site 290340003606 Mg++ binding site; other site 290340003607 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 290340003608 active site 290340003609 substrate binding site [chemical binding]; other site 290340003610 CoA binding site [chemical binding]; other site 290340003611 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290340003612 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 290340003613 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340003614 active site 290340003615 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 290340003616 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290340003617 5S rRNA interface [nucleotide binding]; other site 290340003618 CTC domain interface [polypeptide binding]; other site 290340003619 L16 interface [polypeptide binding]; other site 290340003620 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290340003621 putative active site [active] 290340003622 catalytic residue [active] 290340003623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003624 DNA binding residues [nucleotide binding] 290340003625 dimerization interface [polypeptide binding]; other site 290340003626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003627 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 290340003628 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 290340003629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003630 DNA binding residues [nucleotide binding] 290340003631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003632 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290340003633 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290340003634 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340003635 catalytic residue [active] 290340003636 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290340003637 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290340003638 trimerization site [polypeptide binding]; other site 290340003639 active site 290340003640 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 290340003641 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 290340003642 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290340003643 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 290340003644 putative NAD(P) binding site [chemical binding]; other site 290340003645 putative active site [active] 290340003646 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290340003647 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 290340003648 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 290340003649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340003650 ATP binding site [chemical binding]; other site 290340003651 putative Mg++ binding site [ion binding]; other site 290340003652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340003653 nucleotide binding region [chemical binding]; other site 290340003654 ATP-binding site [chemical binding]; other site 290340003655 TRCF domain; Region: TRCF; cl04088 290340003656 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 290340003657 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 290340003658 intersubunit interface [polypeptide binding]; other site 290340003659 active site 290340003660 catalytic residue [active] 290340003661 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290340003662 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340003663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003664 putative DNA binding site [nucleotide binding]; other site 290340003665 putative Zn2+ binding site [ion binding]; other site 290340003666 Cation efflux family; Region: Cation_efflux; cl00316 290340003667 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340003668 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340003669 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290340003670 Catalytic site [active] 290340003671 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003673 DNA binding site [nucleotide binding] 290340003674 domain linker motif; other site 290340003675 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340003676 ligand binding site [chemical binding]; other site 290340003677 dimerization interface [polypeptide binding]; other site 290340003678 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 290340003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003680 putative substrate translocation pore; other site 290340003681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003682 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340003683 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 290340003684 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003685 active site 290340003686 DNA binding site [nucleotide binding] 290340003687 Int/Topo IB signature motif; other site 290340003688 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 290340003689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003690 active site 290340003691 DNA binding site [nucleotide binding] 290340003692 Int/Topo IB signature motif; other site 290340003693 SH3 domain-containing protein; Provisional; Region: PRK10884 290340003694 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340003695 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290340003696 AMP-binding enzyme; Region: AMP-binding; cl15778 290340003697 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340003698 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340003699 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340003700 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340003701 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340003702 Protein of unknown function (DUF779); Region: DUF779; cl01432 290340003703 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340003704 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340003705 NAD(P) binding site [chemical binding]; other site 290340003706 catalytic residues [active] 290340003707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003709 putative substrate translocation pore; other site 290340003710 HTH-like domain; Region: HTH_21; pfam13276 290340003711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340003712 Integrase core domain; Region: rve; cl01316 290340003713 Integrase core domain; Region: rve_3; cl15866 290340003714 Helix-turn-helix domains; Region: HTH; cl00088 290340003715 Cupin domain; Region: Cupin_2; cl09118 290340003716 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 290340003717 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 290340003718 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 290340003719 putative dimer interface [polypeptide binding]; other site 290340003720 ligand binding site [chemical binding]; other site 290340003721 Zn binding site [ion binding]; other site 290340003722 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003723 active site 290340003724 DNA binding site [nucleotide binding] 290340003725 Int/Topo IB signature motif; other site 290340003726 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 290340003727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003728 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290340003729 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290340003730 active site 290340003731 DNA binding site [nucleotide binding] 290340003732 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290340003733 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 290340003734 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290340003735 active site 290340003736 Helix-turn-helix domains; Region: HTH; cl00088 290340003737 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290340003738 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 290340003739 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290340003740 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 290340003741 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 290340003742 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290340003743 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290340003744 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 290340003745 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 290340003746 active site 290340003747 substrate binding site [chemical binding]; other site 290340003748 metal binding site [ion binding]; metal-binding site 290340003749 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340003750 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340003751 substrate binding [chemical binding]; other site 290340003752 active site 290340003753 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340003754 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 290340003755 active site 290340003756 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 290340003757 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 290340003758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003760 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340003761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340003762 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290340003763 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 290340003764 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290340003765 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290340003766 [4Fe-4S] binding site [ion binding]; other site 290340003767 molybdopterin cofactor binding site; other site 290340003768 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 290340003769 molybdopterin cofactor binding site; other site 290340003770 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 290340003771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003772 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340003773 putative substrate translocation pore; other site 290340003774 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290340003775 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340003776 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340003777 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340003778 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340003779 carboxyltransferase (CT) interaction site; other site 290340003780 biotinylation site [posttranslational modification]; other site 290340003781 Maf-like protein; Region: Maf; pfam02545 290340003782 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290340003783 active site 290340003784 dimer interface [polypeptide binding]; other site 290340003785 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 290340003786 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 290340003787 Helix-turn-helix domains; Region: HTH; cl00088 290340003788 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 290340003789 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290340003790 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 290340003791 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 290340003792 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 290340003793 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290340003794 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290340003795 short chain dehydrogenase; Provisional; Region: PRK08278 290340003796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003797 NAD(P) binding site [chemical binding]; other site 290340003798 active site 290340003799 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290340003800 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 290340003801 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290340003802 Bacterial PH domain; Region: DUF304; cl01348 290340003803 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 290340003804 cyclase homology domain; Region: CHD; cd07302 290340003805 nucleotidyl binding site; other site 290340003806 metal binding site [ion binding]; metal-binding site 290340003807 dimer interface [polypeptide binding]; other site 290340003808 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003809 Interdomain contacts; other site 290340003810 Cytokine receptor motif; other site 290340003811 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003812 Interdomain contacts; other site 290340003813 Cytokine receptor motif; other site 290340003814 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 290340003815 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003816 Interdomain contacts; other site 290340003817 Cytokine receptor motif; other site 290340003818 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003819 Interdomain contacts; other site 290340003820 Cytokine receptor motif; other site 290340003821 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340003822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340003823 Walker A motif; other site 290340003824 ATP binding site [chemical binding]; other site 290340003825 Walker B motif; other site 290340003826 arginine finger; other site 290340003827 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340003828 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340003829 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 290340003830 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 290340003831 RDD family; Region: RDD; cl00746 290340003832 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290340003833 phosphopeptide binding site; other site 290340003834 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290340003835 Protein phosphatase 2C; Region: PP2C; pfam00481 290340003836 active site 290340003837 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290340003838 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340003839 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340003840 active site 290340003841 ATP binding site [chemical binding]; other site 290340003842 substrate binding site [chemical binding]; other site 290340003843 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340003844 substrate binding site [chemical binding]; other site 290340003845 activation loop (A-loop); other site 290340003846 activation loop (A-loop); other site 290340003847 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340003848 phosphopeptide binding site; other site 290340003849 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 290340003850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003852 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290340003853 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290340003854 nucleotide binding pocket [chemical binding]; other site 290340003855 K-X-D-G motif; other site 290340003856 catalytic site [active] 290340003857 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290340003858 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290340003859 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290340003860 Dimer interface [polypeptide binding]; other site 290340003861 BRCT sequence motif; other site 290340003862 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290340003863 active site 290340003864 dimerization interface [polypeptide binding]; other site 290340003865 Predicted ATPase [General function prediction only]; Region: COG4637 290340003866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340003867 Walker A/P-loop; other site 290340003868 ATP binding site [chemical binding]; other site 290340003869 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340003870 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340003871 active site 290340003872 catalytic tetrad [active] 290340003873 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340003874 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340003875 active site 290340003876 non-prolyl cis peptide bond; other site 290340003877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340003878 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290340003879 Walker A/P-loop; other site 290340003880 ATP binding site [chemical binding]; other site 290340003881 Q-loop/lid; other site 290340003882 ABC transporter signature motif; other site 290340003883 Walker B; other site 290340003884 D-loop; other site 290340003885 H-loop/switch region; other site 290340003886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340003887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340003888 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340003889 NMT1-like family; Region: NMT1_2; cl15260 290340003890 Predicted acetyltransferase [General function prediction only]; Region: COG3153 290340003891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340003892 Coenzyme A binding pocket [chemical binding]; other site 290340003893 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 290340003894 homotrimer interaction site [polypeptide binding]; other site 290340003895 putative active site [active] 290340003896 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340003897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 290340003898 active site 290340003899 dimerization interface [polypeptide binding]; other site 290340003900 Helix-turn-helix domains; Region: HTH; cl00088 290340003901 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290340003902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290340003903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340003904 ATP binding site [chemical binding]; other site 290340003905 Mg2+ binding site [ion binding]; other site 290340003906 G-X-G motif; other site 290340003907 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 290340003908 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 290340003909 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 290340003910 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340003911 Amidase; Region: Amidase; cl11426 290340003912 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 290340003913 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 290340003914 GatB domain; Region: GatB_Yqey; cl11497 290340003915 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290340003916 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340003918 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003920 dimer interface [polypeptide binding]; other site 290340003921 conserved gate region; other site 290340003922 putative PBP binding loops; other site 290340003923 ABC-ATPase subunit interface; other site 290340003924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340003925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003927 DNA binding site [nucleotide binding] 290340003928 domain linker motif; other site 290340003929 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340003930 dimerization interface [polypeptide binding]; other site 290340003931 ligand binding site [chemical binding]; other site 290340003932 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340003933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003934 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340003935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340003936 Helix-turn-helix domains; Region: HTH; cl00088 290340003937 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340003938 putative dimerization interface [polypeptide binding]; other site 290340003939 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290340003940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003941 NAD(P) binding site [chemical binding]; other site 290340003942 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290340003943 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290340003944 substrate-cofactor binding pocket; other site 290340003945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340003946 catalytic residue [active] 290340003947 Helix-turn-helix domains; Region: HTH; cl00088 290340003948 HTH-like domain; Region: HTH_21; pfam13276 290340003949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340003950 Integrase core domain; Region: rve; cl01316 290340003951 Integrase core domain; Region: rve_3; cl15866 290340003952 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340003953 imidazolonepropionase; Provisional; Region: PRK14085 290340003954 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 290340003955 active site 290340003956 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 290340003957 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340003958 NPCBM/NEW2 domain; Region: NPCBM; cl07060 290340003959 NPCBM/NEW2 domain; Region: NPCBM; cl07060 290340003960 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 290340003961 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290340003962 dimer interface [polypeptide binding]; other site 290340003963 active site 290340003964 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340003965 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340003966 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290340003967 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340003968 putative substrate binding site [chemical binding]; other site 290340003969 putative ATP binding site [chemical binding]; other site 290340003970 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290340003971 intersubunit interface [polypeptide binding]; other site 290340003972 active site 290340003973 zinc binding site [ion binding]; other site 290340003974 Na+ binding site [ion binding]; other site 290340003975 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340003976 Helix-turn-helix domains; Region: HTH; cl00088 290340003977 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340003978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340003979 catalytic core [active] 290340003980 CAAX protease self-immunity; Region: Abi; cl00558 290340003981 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340003982 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 290340003983 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340003984 homodimer interface [polypeptide binding]; other site 290340003985 substrate-cofactor binding pocket; other site 290340003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340003987 catalytic residue [active] 290340003988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340003989 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 290340003990 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 290340003991 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340003992 active site 290340003993 catalytic triad [active] 290340003994 oxyanion hole [active] 290340003995 Predicted esterase [General function prediction only]; Region: COG0400 290340003996 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340003997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 290340003998 Protein of unknown function, DUF606; Region: DUF606; cl01273 290340003999 Protein of unknown function, DUF606; Region: DUF606; cl01273 290340004000 glycyl-tRNA synthetase; Provisional; Region: PRK04173 290340004001 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290340004002 motif 1; other site 290340004003 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 290340004004 active site 290340004005 motif 2; other site 290340004006 motif 3; other site 290340004007 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 290340004008 anticodon binding site; other site 290340004009 YibE/F-like protein; Region: YibE_F; cl02259 290340004010 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 290340004011 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290340004012 FMN binding site [chemical binding]; other site 290340004013 active site 290340004014 catalytic residues [active] 290340004015 substrate binding site [chemical binding]; other site 290340004016 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 290340004017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290340004018 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 290340004019 DNA primase; Validated; Region: dnaG; PRK05667 290340004020 CHC2 zinc finger; Region: zf-CHC2; cl15369 290340004021 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340004022 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340004023 active site 290340004024 metal binding site [ion binding]; metal-binding site 290340004025 interdomain interaction site; other site 290340004026 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290340004027 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 290340004028 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 290340004029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004030 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 290340004031 putative substrate translocation pore; other site 290340004032 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290340004033 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 290340004034 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 290340004035 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340004036 putative ADP-binding pocket [chemical binding]; other site 290340004037 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340004038 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290340004039 rRNA interaction site [nucleotide binding]; other site 290340004040 S8 interaction site; other site 290340004041 putative laminin-1 binding site; other site 290340004042 elongation factor Ts; Provisional; Region: tsf; PRK09377 290340004043 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 290340004044 Elongation factor TS; Region: EF_TS; pfam00889 290340004045 Elongation factor TS; Region: EF_TS; pfam00889 290340004046 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290340004047 putative nucleotide binding site [chemical binding]; other site 290340004048 uridine monophosphate binding site [chemical binding]; other site 290340004049 homohexameric interface [polypeptide binding]; other site 290340004050 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290340004051 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 290340004052 hinge region; other site 290340004053 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 290340004054 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004055 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 290340004056 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004057 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004058 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290340004059 Sodium:solute symporter family; Region: SSF; cl00456 290340004060 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 290340004061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004062 active site 290340004063 phosphorylation site [posttranslational modification] 290340004064 intermolecular recognition site; other site 290340004065 dimerization interface [polypeptide binding]; other site 290340004066 LytTr DNA-binding domain; Region: LytTR; cl04498 290340004067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340004068 Histidine kinase; Region: His_kinase; pfam06580 290340004069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004070 ATP binding site [chemical binding]; other site 290340004071 Mg2+ binding site [ion binding]; other site 290340004072 G-X-G motif; other site 290340004073 Protein of unknown function, DUF485; Region: DUF485; cl01231 290340004074 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290340004075 Sodium:solute symporter family; Region: SSF; cl00456 290340004076 hypothetical protein; Provisional; Region: PRK07945 290340004077 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 290340004078 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290340004079 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340004080 Helix-turn-helix domains; Region: HTH; cl00088 290340004081 Helix-turn-helix domains; Region: HTH; cl00088 290340004082 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340004083 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340004084 tetramer interface [polypeptide binding]; other site 290340004085 TPP-binding site [chemical binding]; other site 290340004086 heterodimer interface [polypeptide binding]; other site 290340004087 phosphorylation loop region [posttranslational modification] 290340004088 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340004089 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340004090 alpha subunit interface [polypeptide binding]; other site 290340004091 TPP binding site [chemical binding]; other site 290340004092 heterodimer interface [polypeptide binding]; other site 290340004093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340004094 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 290340004095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340004096 E3 interaction surface; other site 290340004097 lipoyl attachment site [posttranslational modification]; other site 290340004098 e3 binding domain; Region: E3_binding; pfam02817 290340004099 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 290340004100 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340004101 extended (e) SDRs; Region: SDR_e; cd08946 290340004102 NAD(P) binding site [chemical binding]; other site 290340004103 active site 290340004104 substrate binding site [chemical binding]; other site 290340004105 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340004106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340004107 active site 290340004108 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 290340004109 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290340004110 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290340004111 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290340004112 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340004113 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340004114 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340004115 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340004116 carboxyltransferase (CT) interaction site; other site 290340004117 biotinylation site [posttranslational modification]; other site 290340004118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340004119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340004120 active site 290340004121 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340004122 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340004123 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 290340004124 putative active site [active] 290340004125 putative catalytic site [active] 290340004126 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340004127 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340004128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004129 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340004130 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340004131 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340004132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004133 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340004134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340004135 dimer interface [polypeptide binding]; other site 290340004136 conserved gate region; other site 290340004137 putative PBP binding loops; other site 290340004138 ABC-ATPase subunit interface; other site 290340004139 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 290340004140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340004141 dimer interface [polypeptide binding]; other site 290340004142 conserved gate region; other site 290340004143 putative PBP binding loops; other site 290340004144 ABC-ATPase subunit interface; other site 290340004145 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340004146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340004147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340004148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340004149 DNA binding site [nucleotide binding] 290340004150 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340004151 putative dimerization interface [polypeptide binding]; other site 290340004152 putative ligand binding site [chemical binding]; other site 290340004153 Lipase maturation factor; Region: LMF1; pfam06762 290340004154 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290340004155 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290340004156 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290340004157 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290340004158 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 290340004159 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290340004160 active site 290340004161 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290340004162 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290340004163 putative substrate binding region [chemical binding]; other site 290340004164 YCII-related domain; Region: YCII; cl00999 290340004165 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 290340004166 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290340004167 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290340004168 Predicted acetyltransferase [General function prediction only]; Region: COG3393 290340004169 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 290340004170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340004171 Helix-turn-helix domains; Region: HTH; cl00088 290340004172 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340004173 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340004174 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 290340004175 Walker A/P-loop; other site 290340004176 ATP binding site [chemical binding]; other site 290340004177 Q-loop/lid; other site 290340004178 ABC transporter signature motif; other site 290340004179 Walker B; other site 290340004180 D-loop; other site 290340004181 H-loop/switch region; other site 290340004182 prolyl-tRNA synthetase; Provisional; Region: PRK09194 290340004183 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 290340004184 dimer interface [polypeptide binding]; other site 290340004185 motif 1; other site 290340004186 active site 290340004187 motif 2; other site 290340004188 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 290340004189 putative deacylase active site [active] 290340004190 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290340004191 active site 290340004192 motif 3; other site 290340004193 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 290340004194 anticodon binding site; other site 290340004195 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 290340004196 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340004197 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340004198 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 290340004199 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 290340004200 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290340004201 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 290340004202 Sm1 motif; other site 290340004203 D1 - D2 interaction site; other site 290340004204 D3 - B interaction site; other site 290340004205 Hfq - Hfq interaction site; other site 290340004206 RNA binding pocket [nucleotide binding]; other site 290340004207 Sm2 motif; other site 290340004208 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 290340004209 NusA N-terminal domain; Region: NusA_N; pfam08529 290340004210 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290340004211 RNA binding site [nucleotide binding]; other site 290340004212 homodimer interface [polypeptide binding]; other site 290340004213 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 290340004214 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290340004215 G-X-X-G motif; other site 290340004216 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 290340004217 putative RNA binding cleft [nucleotide binding]; other site 290340004218 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290340004219 translation initiation factor IF-2; Region: IF-2; TIGR00487 290340004220 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290340004221 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290340004222 G1 box; other site 290340004223 putative GEF interaction site [polypeptide binding]; other site 290340004224 GTP/Mg2+ binding site [chemical binding]; other site 290340004225 Switch I region; other site 290340004226 G2 box; other site 290340004227 G3 box; other site 290340004228 Switch II region; other site 290340004229 G4 box; other site 290340004230 G5 box; other site 290340004231 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290340004232 Translation-initiation factor 2; Region: IF-2; pfam11987 290340004233 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290340004234 Ribosome-binding factor A; Region: RBFA; cl00542 290340004235 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340004236 nucleoside/Zn binding site; other site 290340004237 dimer interface [polypeptide binding]; other site 290340004238 catalytic motif [active] 290340004239 aspartate aminotransferase; Provisional; Region: PRK05764 290340004240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004242 homodimer interface [polypeptide binding]; other site 290340004243 catalytic residue [active] 290340004244 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 290340004245 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 290340004246 RNA binding site [nucleotide binding]; other site 290340004247 active site 290340004248 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 290340004249 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290340004250 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290340004251 active site 290340004252 Riboflavin kinase; Region: Flavokinase; cl03312 290340004253 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290340004254 16S/18S rRNA binding site [nucleotide binding]; other site 290340004255 S13e-L30e interaction site [polypeptide binding]; other site 290340004256 25S rRNA binding site [nucleotide binding]; other site 290340004257 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 290340004258 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 290340004259 oligomer interface [polypeptide binding]; other site 290340004260 RNA binding site [nucleotide binding]; other site 290340004261 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290340004262 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290340004263 RNase E interface [polypeptide binding]; other site 290340004264 trimer interface [polypeptide binding]; other site 290340004265 active site 290340004266 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290340004267 putative nucleic acid binding region [nucleotide binding]; other site 290340004268 G-X-X-G motif; other site 290340004269 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290340004270 RNA binding site [nucleotide binding]; other site 290340004271 domain interface; other site 290340004272 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290340004273 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290340004274 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290340004275 Ubiquitin-like proteins; Region: UBQ; cl00155 290340004276 charged pocket; other site 290340004277 hydrophobic patch; other site 290340004278 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290340004279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004280 FeS/SAM binding site; other site 290340004281 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290340004282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004284 active site 290340004285 phosphorylation site [posttranslational modification] 290340004286 intermolecular recognition site; other site 290340004287 dimerization interface [polypeptide binding]; other site 290340004288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340004289 DNA binding site [nucleotide binding] 290340004290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340004291 dimer interface [polypeptide binding]; other site 290340004292 phosphorylation site [posttranslational modification] 290340004293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004294 ATP binding site [chemical binding]; other site 290340004295 Mg2+ binding site [ion binding]; other site 290340004296 G-X-G motif; other site 290340004297 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 290340004298 Moco binding site; other site 290340004299 metal coordination site [ion binding]; other site 290340004300 dimerization interface [polypeptide binding]; other site 290340004301 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340004302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340004303 dimer interface [polypeptide binding]; other site 290340004304 putative functional site; other site 290340004305 putative MPT binding site; other site 290340004306 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290340004307 trimer interface [polypeptide binding]; other site 290340004308 dimer interface [polypeptide binding]; other site 290340004309 putative active site [active] 290340004310 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 290340004311 MoaE homodimer interface [polypeptide binding]; other site 290340004312 MoaD interaction [polypeptide binding]; other site 290340004313 active site residues [active] 290340004314 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290340004315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004316 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290340004317 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290340004318 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340004319 dimer interface [polypeptide binding]; other site 290340004320 active site 290340004321 catalytic residue [active] 290340004322 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 290340004323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340004324 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290340004325 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290340004326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340004327 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 290340004328 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290340004329 Competence-damaged protein; Region: CinA; cl00666 290340004330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340004331 non-specific DNA binding site [nucleotide binding]; other site 290340004332 salt bridge; other site 290340004333 sequence-specific DNA binding site [nucleotide binding]; other site 290340004334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340004335 Helix-turn-helix domains; Region: HTH; cl00088 290340004336 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 290340004337 recombinase A; Provisional; Region: recA; PRK09354 290340004338 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290340004339 hexamer interface [polypeptide binding]; other site 290340004340 Walker A motif; other site 290340004341 ATP binding site [chemical binding]; other site 290340004342 Walker B motif; other site 290340004343 RecX family; Region: RecX; cl00936 290340004344 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 290340004345 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290340004346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004347 FeS/SAM binding site; other site 290340004348 TRAM domain; Region: TRAM; cl01282 290340004349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340004350 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290340004351 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290340004352 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 290340004353 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 290340004354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340004355 S-adenosylmethionine binding site [chemical binding]; other site 290340004356 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 290340004357 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290340004358 HflX GTPase family; Region: HflX; cd01878 290340004359 G1 box; other site 290340004360 GTP/Mg2+ binding site [chemical binding]; other site 290340004361 Switch I region; other site 290340004362 G2 box; other site 290340004363 G3 box; other site 290340004364 Switch II region; other site 290340004365 G4 box; other site 290340004366 G5 box; other site 290340004367 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 290340004368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340004369 LexA repressor; Validated; Region: PRK00215 290340004370 Helix-turn-helix domains; Region: HTH; cl00088 290340004371 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290340004372 Catalytic site [active] 290340004373 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 290340004374 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 290340004375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340004376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004377 homodimer interface [polypeptide binding]; other site 290340004378 catalytic residue [active] 290340004379 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290340004380 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 290340004381 4-fold oligomerization interface [polypeptide binding]; other site 290340004382 putative active site pocket [active] 290340004383 metal binding residues [ion binding]; metal-binding site 290340004384 3-fold/trimer interface [polypeptide binding]; other site 290340004385 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 290340004386 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290340004387 putative active site [active] 290340004388 oxyanion strand; other site 290340004389 catalytic triad [active] 290340004390 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 290340004391 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290340004392 catalytic residues [active] 290340004393 translation initiation factor IF-3; Region: infC; TIGR00168 290340004394 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290340004395 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290340004396 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 290340004397 ribosomal protein L20; Region: rpl20; CHL00068 290340004398 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290340004399 23S rRNA binding site [nucleotide binding]; other site 290340004400 L21 binding site [polypeptide binding]; other site 290340004401 L13 binding site [polypeptide binding]; other site 290340004402 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 290340004403 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290340004404 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 290340004405 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290340004406 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290340004407 Cation efflux family; Region: Cation_efflux; cl00316 290340004408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004409 putative substrate translocation pore; other site 290340004410 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290340004411 active site 290340004412 8-oxo-dGMP binding site [chemical binding]; other site 290340004413 nudix motif; other site 290340004414 metal binding site [ion binding]; metal-binding site 290340004415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004416 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290340004417 FeS/SAM binding site; other site 290340004418 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 290340004419 putative substrate binding pocket [chemical binding]; other site 290340004420 AC domain interface; other site 290340004421 catalytic triad [active] 290340004422 AB domain interface; other site 290340004423 interchain disulfide; other site 290340004424 Protein of unknown function (DUF541); Region: SIMPL; cl01077 290340004425 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290340004426 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290340004427 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290340004428 dimer interface [polypeptide binding]; other site 290340004429 motif 1; other site 290340004430 active site 290340004431 motif 2; other site 290340004432 motif 3; other site 290340004433 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290340004434 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290340004435 putative tRNA-binding site [nucleotide binding]; other site 290340004436 B3/4 domain; Region: B3_4; cl11458 290340004437 tRNA synthetase B5 domain; Region: B5; cl08394 290340004438 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290340004439 dimer interface [polypeptide binding]; other site 290340004440 motif 1; other site 290340004441 motif 3; other site 290340004442 motif 2; other site 290340004443 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 290340004444 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340004445 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290340004446 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290340004447 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 290340004448 Zn binding site [ion binding]; other site 290340004449 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290340004450 AMP-binding enzyme; Region: AMP-binding; cl15778 290340004451 peptide synthase; Validated; Region: PRK05691 290340004452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290340004453 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 290340004454 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004455 putative trimer interface [polypeptide binding]; other site 290340004456 putative CoA binding site [chemical binding]; other site 290340004457 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004458 putative CoA binding site [chemical binding]; other site 290340004459 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004460 putative trimer interface [polypeptide binding]; other site 290340004461 putative CoA binding site [chemical binding]; other site 290340004462 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 290340004463 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 290340004464 NADP binding site [chemical binding]; other site 290340004465 dimer interface [polypeptide binding]; other site 290340004466 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290340004467 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340004468 putative di-iron ligands [ion binding]; other site 290340004469 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290340004470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004471 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290340004472 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 290340004473 heterotetramer interface [polypeptide binding]; other site 290340004474 active site pocket [active] 290340004475 cleavage site 290340004476 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 290340004477 feedback inhibition sensing region; other site 290340004478 homohexameric interface [polypeptide binding]; other site 290340004479 nucleotide binding site [chemical binding]; other site 290340004480 N-acetyl-L-glutamate binding site [chemical binding]; other site 290340004481 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 290340004482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340004483 inhibitor-cofactor binding pocket; inhibition site 290340004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004485 catalytic residue [active] 290340004486 ornithine carbamoyltransferase; Provisional; Region: PRK00779 290340004487 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290340004488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004489 arginine repressor; Provisional; Region: PRK03341 290340004490 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290340004491 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290340004492 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 290340004493 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290340004494 ANP binding site [chemical binding]; other site 290340004495 Substrate Binding Site II [chemical binding]; other site 290340004496 Substrate Binding Site I [chemical binding]; other site 290340004497 argininosuccinate lyase; Provisional; Region: PRK00855 290340004498 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290340004499 active sites [active] 290340004500 tetramer interface [polypeptide binding]; other site 290340004501 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290340004502 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 290340004503 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 290340004504 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 290340004505 AlkA N-terminal domain; Region: AlkA_N; cl05528 290340004506 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 290340004507 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340004508 minor groove reading motif; other site 290340004509 helix-hairpin-helix signature motif; other site 290340004510 substrate binding pocket [chemical binding]; other site 290340004511 active site 290340004512 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 290340004513 active site 290340004514 DNA binding site [nucleotide binding] 290340004515 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 290340004516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340004517 Family description; Region: UvrD_C_2; cl15862 290340004518 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290340004519 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290340004520 active site 290340004521 HIGH motif; other site 290340004522 dimer interface [polypeptide binding]; other site 290340004523 KMSKS motif; other site 290340004524 transcription termination factor Rho; Provisional; Region: PRK12678 290340004525 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 290340004526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340004527 active site 290340004528 motif I; other site 290340004529 motif II; other site 290340004530 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340004531 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 290340004532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 290340004533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340004534 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340004535 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 290340004536 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 290340004537 Walker A/P-loop; other site 290340004538 ATP binding site [chemical binding]; other site 290340004539 Q-loop/lid; other site 290340004540 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 290340004541 ABC transporter signature motif; other site 290340004542 Walker B; other site 290340004543 D-loop; other site 290340004544 H-loop/switch region; other site 290340004545 CTP synthetase; Validated; Region: pyrG; PRK05380 290340004546 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290340004547 Catalytic site [active] 290340004548 active site 290340004549 UTP binding site [chemical binding]; other site 290340004550 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290340004551 active site 290340004552 putative oxyanion hole; other site 290340004553 catalytic triad [active] 290340004554 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290340004555 dimer interface [polypeptide binding]; other site 290340004556 ADP-ribose binding site [chemical binding]; other site 290340004557 active site 290340004558 nudix motif; other site 290340004559 metal binding site [ion binding]; metal-binding site 290340004560 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 290340004561 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290340004562 active site 290340004563 Int/Topo IB signature motif; other site 290340004564 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340004565 nudix motif; other site 290340004566 citrate synthase; Provisional; Region: PRK14033 290340004567 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290340004568 oxalacetate binding site [chemical binding]; other site 290340004569 citrylCoA binding site [chemical binding]; other site 290340004570 coenzyme A binding site [chemical binding]; other site 290340004571 catalytic triad [active] 290340004572 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 290340004573 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340004574 tetramer interface [polypeptide binding]; other site 290340004575 active site 290340004576 Mg2+/Mn2+ binding site [ion binding]; other site 290340004577 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 290340004578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340004579 DNA-binding site [nucleotide binding]; DNA binding site 290340004580 FCD domain; Region: FCD; cl11656 290340004581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340004582 S-adenosylmethionine binding site [chemical binding]; other site 290340004583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340004584 DNA binding residues [nucleotide binding] 290340004585 dimerization interface [polypeptide binding]; other site 290340004586 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340004587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004588 active site 290340004589 phosphorylation site [posttranslational modification] 290340004590 intermolecular recognition site; other site 290340004591 dimerization interface [polypeptide binding]; other site 290340004592 FaeA-like protein; Region: FaeA; pfam04703 290340004593 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290340004594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004595 ATP binding site [chemical binding]; other site 290340004596 G-X-G motif; other site 290340004597 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290340004598 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290340004599 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340004600 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004601 P-loop; other site 290340004602 Magnesium ion binding site [ion binding]; other site 290340004603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004604 Magnesium ion binding site [ion binding]; other site 290340004605 ScpA/B protein; Region: ScpA_ScpB; cl00598 290340004606 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 290340004607 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 290340004608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340004609 RNA binding surface [nucleotide binding]; other site 290340004610 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 290340004611 active site 290340004612 prephenate dehydrogenase; Validated; Region: PRK06545 290340004613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004614 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290340004615 cytidylate kinase; Provisional; Region: cmk; PRK00023 290340004616 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290340004617 CMP-binding site; other site 290340004618 The sites determining sugar specificity; other site 290340004619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340004620 putative acyl-acceptor binding pocket; other site 290340004621 GTP-binding protein Der; Reviewed; Region: PRK03003 290340004622 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290340004623 G1 box; other site 290340004624 GTP/Mg2+ binding site [chemical binding]; other site 290340004625 Switch I region; other site 290340004626 G2 box; other site 290340004627 Switch II region; other site 290340004628 G3 box; other site 290340004629 G4 box; other site 290340004630 G5 box; other site 290340004631 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290340004632 G1 box; other site 290340004633 GTP/Mg2+ binding site [chemical binding]; other site 290340004634 Switch I region; other site 290340004635 G2 box; other site 290340004636 G3 box; other site 290340004637 Switch II region; other site 290340004638 G4 box; other site 290340004639 G5 box; other site 290340004640 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340004641 Helix-turn-helix domains; Region: HTH; cl00088 290340004642 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340004643 lipoyl attachment site [posttranslational modification]; other site 290340004644 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340004645 phosphopeptide binding site; other site 290340004646 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 290340004647 DNA binding residues [nucleotide binding] 290340004648 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340004649 Bifunctional nuclease; Region: DNase-RNase; cl00553 290340004650 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 290340004651 DNA binding residues [nucleotide binding] 290340004652 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340004653 putative dimer interface [polypeptide binding]; other site 290340004654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340004655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004656 Magnesium ion binding site [ion binding]; other site 290340004657 pyruvate carboxylase; Reviewed; Region: PRK12999 290340004658 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340004659 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340004660 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340004661 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290340004662 active site 290340004663 catalytic residues [active] 290340004664 metal binding site [ion binding]; metal-binding site 290340004665 homodimer binding site [polypeptide binding]; other site 290340004666 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340004667 carboxyltransferase (CT) interaction site; other site 290340004668 biotinylation site [posttranslational modification]; other site 290340004669 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290340004670 AMP-binding enzyme; Region: AMP-binding; cl15778 290340004671 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340004672 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340004673 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 290340004674 Esterase/lipase [General function prediction only]; Region: COG1647 290340004675 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340004676 putative acyl-acceptor binding pocket; other site 290340004677 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 290340004678 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340004679 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340004680 active site 290340004681 ATP binding site [chemical binding]; other site 290340004682 substrate binding site [chemical binding]; other site 290340004683 activation loop (A-loop); other site 290340004684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 290340004685 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004686 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004687 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004688 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004689 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340004690 putative peptidoglycan binding site; other site 290340004691 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340004692 putative peptidoglycan binding site; other site 290340004693 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340004694 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340004695 putative peptidoglycan binding site; other site 290340004696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 290340004697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290340004698 catalytic residue [active] 290340004699 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290340004700 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340004701 substrate binding pocket [chemical binding]; other site 290340004702 chain length determination region; other site 290340004703 substrate-Mg2+ binding site; other site 290340004704 catalytic residues [active] 290340004705 aspartate-rich region 1; other site 290340004706 active site lid residues [active] 290340004707 aspartate-rich region 2; other site 290340004708 DNA polymerase IV; Validated; Region: PRK02406 290340004709 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290340004710 active site 290340004711 DNA binding site [nucleotide binding] 290340004712 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340004713 cell division protein MraZ; Reviewed; Region: PRK00326 290340004714 MraZ protein; Region: MraZ; pfam02381 290340004715 MraZ protein; Region: MraZ; pfam02381 290340004716 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 290340004717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004718 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290340004719 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290340004720 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340004721 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290340004722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004726 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 290340004727 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004728 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004729 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290340004730 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290340004731 Mg++ binding site [ion binding]; other site 290340004732 putative catalytic motif [active] 290340004733 putative substrate binding site [chemical binding]; other site 290340004734 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 290340004735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004737 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 290340004738 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290340004739 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290340004740 active site 290340004741 homodimer interface [polypeptide binding]; other site 290340004742 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290340004743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004746 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290340004747 Cell division protein FtsQ; Region: FtsQ; pfam03799 290340004748 cell division protein FtsZ; Validated; Region: PRK09330 290340004749 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290340004750 nucleotide binding site [chemical binding]; other site 290340004751 SulA interaction site; other site 290340004752 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290340004753 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 290340004754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 290340004755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340004756 catalytic residue [active] 290340004757 Protein of unknown function (DUF552); Region: DUF552; cl00775 290340004758 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004759 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 290340004760 lipoprotein signal peptidase; Provisional; Region: PRK14787 290340004761 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 290340004762 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 290340004763 active site 290340004764 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290340004765 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 290340004766 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 290340004767 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290340004768 generic binding surface II; other site 290340004769 generic binding surface I; other site 290340004770 Flavin Reductases; Region: FlaRed; cl00801 290340004771 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290340004772 histidinol dehydrogenase; Region: hisD; TIGR00069 290340004773 NAD binding site [chemical binding]; other site 290340004774 dimerization interface [polypeptide binding]; other site 290340004775 product binding site; other site 290340004776 substrate binding site [chemical binding]; other site 290340004777 zinc binding site [ion binding]; other site 290340004778 catalytic residues [active] 290340004779 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 290340004780 ATP cone domain; Region: ATP-cone; pfam03477 290340004781 classical (c) SDRs; Region: SDR_c; cd05233 290340004782 short chain dehydrogenase; Provisional; Region: PRK06123 290340004783 NAD(P) binding site [chemical binding]; other site 290340004784 active site 290340004785 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340004786 D-allose kinase; Provisional; Region: PRK09698 290340004787 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340004788 active site 290340004789 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290340004790 oligomerization interface [polypeptide binding]; other site 290340004791 active site 290340004792 metal binding site [ion binding]; metal-binding site 290340004793 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340004794 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340004795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340004796 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 290340004797 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290340004798 metal binding triad; other site 290340004799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290340004800 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290340004801 metal binding triad; other site 290340004802 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290340004803 Sulfatase; Region: Sulfatase; cl10460 290340004804 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290340004805 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340004806 HTH-like domain; Region: HTH_21; pfam13276 290340004807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340004808 Integrase core domain; Region: rve; cl01316 290340004809 Integrase core domain; Region: rve_3; cl15866 290340004810 Helix-turn-helix domains; Region: HTH; cl00088 290340004811 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340004812 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 290340004813 Int/Topo IB signature motif; other site 290340004814 glutamine synthetase, type I; Region: GlnA; TIGR00653 290340004815 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340004816 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340004817 RDD family; Region: RDD; cl00746 290340004818 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 290340004819 lipoyl synthase; Provisional; Region: PRK05481 290340004820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004821 FeS/SAM binding site; other site 290340004822 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290340004823 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340004824 active site 290340004825 ATP binding site [chemical binding]; other site 290340004826 substrate binding site [chemical binding]; other site 290340004827 activation loop (A-loop); other site 290340004828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004829 TIGR01777 family protein; Region: yfcH 290340004830 NAD(P) binding site [chemical binding]; other site 290340004831 active site 290340004832 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 290340004833 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 290340004834 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290340004835 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 290340004836 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290340004837 protein binding site [polypeptide binding]; other site 290340004838 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 290340004839 Domain interface; other site 290340004840 Peptide binding site; other site 290340004841 Active site tetrad [active] 290340004842 OsmC-like protein; Region: OsmC; cl00767 290340004843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340004844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340004845 active site 290340004846 metal binding site [ion binding]; metal-binding site 290340004847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340004848 E3 interaction surface; other site 290340004849 lipoyl attachment site [posttranslational modification]; other site 290340004850 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340004851 E3 interaction surface; other site 290340004852 lipoyl attachment site [posttranslational modification]; other site 290340004853 e3 binding domain; Region: E3_binding; pfam02817 290340004854 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340004855 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 290340004856 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290340004857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340004858 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340004859 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290340004860 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290340004861 interface (dimer of trimers) [polypeptide binding]; other site 290340004862 Substrate-binding/catalytic site; other site 290340004863 Zn-binding sites [ion binding]; other site 290340004864 PAC2 family; Region: PAC2; cl00847 290340004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340004867 putative substrate translocation pore; other site 290340004868 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340004869 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340004870 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 290340004871 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290340004872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340004873 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290340004874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340004875 DNA binding residues [nucleotide binding] 290340004876 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 290340004877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004878 ATP binding site [chemical binding]; other site 290340004879 Mg2+ binding site [ion binding]; other site 290340004880 G-X-G motif; other site 290340004881 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290340004882 anchoring element; other site 290340004883 dimer interface [polypeptide binding]; other site 290340004884 ATP binding site [chemical binding]; other site 290340004885 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290340004886 active site 290340004887 metal binding site [ion binding]; metal-binding site 290340004888 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290340004889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004891 Peptidase family M48; Region: Peptidase_M48; cl12018 290340004892 Helix-turn-helix domains; Region: HTH; cl00088 290340004893 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290340004894 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 290340004895 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290340004896 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290340004897 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290340004898 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290340004899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340004900 Coenzyme A binding pocket [chemical binding]; other site 290340004901 DinB superfamily; Region: DinB_2; pfam12867 290340004902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340004903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340004904 active site 290340004905 metal binding site [ion binding]; metal-binding site 290340004906 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 290340004907 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 290340004908 CAP-like domain; other site 290340004909 active site 290340004910 primary dimer interface [polypeptide binding]; other site 290340004911 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340004912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 290340004913 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340004914 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 290340004915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004916 CoA-ligase; Region: Ligase_CoA; cl02894 290340004917 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340004918 Sulfatase; Region: Sulfatase; cl10460 290340004919 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290340004920 PglZ domain; Region: PglZ; pfam08665 290340004921 thymidine kinase; Provisional; Region: PRK04296 290340004922 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 290340004923 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340004924 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 290340004925 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290340004926 trimer interface [polypeptide binding]; other site 290340004927 active site 290340004928 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 290340004929 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 290340004930 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340004931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004932 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 290340004933 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340004934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004935 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340004936 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 290340004937 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 290340004938 TRAM domain; Region: TRAM; cl01282 290340004939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340004940 S-adenosylmethionine binding site [chemical binding]; other site 290340004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340004942 aconitate hydratase; Validated; Region: PRK09277 290340004943 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290340004944 substrate binding site [chemical binding]; other site 290340004945 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290340004946 ligand binding site [chemical binding]; other site 290340004947 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290340004948 substrate binding site [chemical binding]; other site 290340004949 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290340004950 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340004951 TPP-binding site [chemical binding]; other site 290340004952 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340004953 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340004954 PYR/PP interface [polypeptide binding]; other site 290340004955 dimer interface [polypeptide binding]; other site 290340004956 TPP binding site [chemical binding]; other site 290340004957 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340004958 Protein of unknown function (DUF402); Region: DUF402; cl00979 290340004959 Protein of unknown function (DUF402); Region: DUF402; cl00979 290340004960 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 290340004961 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340004962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340004963 active site 290340004964 catalytic tetrad [active] 290340004965 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340004966 substrate binding site [chemical binding]; other site 290340004967 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 290340004968 oxyanion hole (OAH) forming residues; other site 290340004969 trimer interface [polypeptide binding]; other site 290340004970 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 290340004971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004972 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340004973 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340004974 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340004975 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290340004976 dimer interface [polypeptide binding]; other site 290340004977 active site 290340004978 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 290340004979 catalytic site [active] 290340004980 putative active site [active] 290340004981 putative substrate binding site [chemical binding]; other site 290340004982 HRDC domain; Region: HRDC; cl02578 290340004983 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 290340004984 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 290340004985 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290340004986 tetramer interface [polypeptide binding]; other site 290340004987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004988 catalytic residue [active] 290340004989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004990 active site 290340004991 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 290340004992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340004993 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340004994 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 290340004995 putative deacylase active site [active] 290340004996 Fe-S metabolism associated domain; Region: SufE; cl00951 290340004997 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340004998 active site residue [active] 290340004999 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340005000 active site residue [active] 290340005001 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 290340005002 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 290340005003 benzoate transporter; Region: benE; TIGR00843 290340005004 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 290340005005 amino acid transporter; Region: 2A0306; TIGR00909 290340005006 Spore germination protein; Region: Spore_permease; cl15802 290340005007 Spore germination protein; Region: Spore_permease; cl15802 290340005008 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290340005009 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340005010 active site 290340005011 catalytic residues [active] 290340005012 metal binding site [ion binding]; metal-binding site 290340005013 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290340005014 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290340005015 putative active site [active] 290340005016 substrate binding site [chemical binding]; other site 290340005017 putative cosubstrate binding site; other site 290340005018 catalytic site [active] 290340005019 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290340005020 substrate binding site [chemical binding]; other site 290340005021 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290340005022 putative RNA binding site [nucleotide binding]; other site 290340005023 16S rRNA methyltransferase B; Provisional; Region: PRK14902 290340005024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340005025 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290340005026 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 290340005027 substrate binding site [chemical binding]; other site 290340005028 hexamer interface [polypeptide binding]; other site 290340005029 metal binding site [ion binding]; metal-binding site 290340005030 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 290340005031 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290340005032 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 290340005033 catalytic motif [active] 290340005034 Zn binding site [ion binding]; other site 290340005035 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340005036 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 290340005037 Lumazine binding domain; Region: Lum_binding; pfam00677 290340005038 Lumazine binding domain; Region: Lum_binding; pfam00677 290340005039 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290340005040 homopentamer interface [polypeptide binding]; other site 290340005041 active site 290340005042 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 290340005043 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290340005044 ATP phosphoribosyltransferase; Region: HisG; cl15266 290340005045 HisG, C-terminal domain; Region: HisG_C; cl06867 290340005046 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290340005047 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290340005048 substrate binding site [chemical binding]; other site 290340005049 glutamase interaction surface [polypeptide binding]; other site 290340005050 TIGR03085 family protein; Region: TIGR03085 290340005051 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 290340005052 anthranilate synthase component I; Provisional; Region: PRK13571 290340005053 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290340005054 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290340005055 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290340005056 active site 290340005057 ribulose/triose binding site [chemical binding]; other site 290340005058 phosphate binding site [ion binding]; other site 290340005059 substrate (anthranilate) binding pocket [chemical binding]; other site 290340005060 product (indole) binding pocket [chemical binding]; other site 290340005061 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290340005062 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 290340005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005064 catalytic residue [active] 290340005065 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 290340005066 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290340005067 substrate binding site [chemical binding]; other site 290340005068 active site 290340005069 catalytic residues [active] 290340005070 heterodimer interface [polypeptide binding]; other site 290340005071 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 290340005072 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290340005073 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290340005074 active site 290340005075 dimer interface [polypeptide binding]; other site 290340005076 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290340005077 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290340005078 active site 290340005079 FMN binding site [chemical binding]; other site 290340005080 substrate binding site [chemical binding]; other site 290340005081 3Fe-4S cluster binding site [ion binding]; other site 290340005082 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290340005083 domain interface; other site 290340005084 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 290340005085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005086 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340005087 pyruvate kinase; Provisional; Region: PRK06247 290340005088 domain interfaces; other site 290340005089 active site 290340005090 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 290340005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340005092 active site 290340005093 phosphorylation site [posttranslational modification] 290340005094 intermolecular recognition site; other site 290340005095 dimerization interface [polypeptide binding]; other site 290340005096 ANTAR domain; Region: ANTAR; cl04297 290340005097 putative phosphoketolase; Provisional; Region: PRK05261 290340005098 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340005099 TPP-binding site [chemical binding]; other site 290340005100 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 290340005101 XFP C-terminal domain; Region: XFP_C; pfam09363 290340005102 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 290340005103 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340005104 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340005105 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340005106 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290340005107 thioredoxin 2; Provisional; Region: PRK10996 290340005108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340005109 catalytic residues [active] 290340005110 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 290340005111 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 290340005112 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005113 Flavin Reductases; Region: FlaRed; cl00801 290340005114 methionine synthase; Provisional; Region: PRK01207 290340005115 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290340005116 substrate binding site [chemical binding]; other site 290340005117 THF binding site; other site 290340005118 zinc-binding site [ion binding]; other site 290340005119 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 290340005120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340005121 Helix-turn-helix domains; Region: HTH; cl00088 290340005122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340005123 dimerization interface [polypeptide binding]; other site 290340005124 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340005125 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340005126 active site 290340005127 catalytic tetrad [active] 290340005128 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 290340005129 hydroperoxidase II; Provisional; Region: katE; PRK11249 290340005130 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 290340005131 heme binding pocket [chemical binding]; other site 290340005132 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 290340005133 domain interactions; other site 290340005134 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290340005135 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340005136 NAD binding site [chemical binding]; other site 290340005137 catalytic Zn binding site [ion binding]; other site 290340005138 structural Zn binding site [ion binding]; other site 290340005139 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 290340005140 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 290340005141 NAD binding site [chemical binding]; other site 290340005142 catalytic Zn binding site [ion binding]; other site 290340005143 structural Zn binding site [ion binding]; other site 290340005144 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340005145 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340005146 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340005147 Helix-turn-helix domains; Region: HTH; cl00088 290340005148 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 290340005149 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290340005150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340005151 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 290340005152 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290340005153 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290340005154 dimer interface [polypeptide binding]; other site 290340005155 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290340005156 chaperone protein DnaJ; Provisional; Region: PRK14299 290340005157 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340005158 HSP70 interaction site [polypeptide binding]; other site 290340005159 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290340005160 substrate binding site [polypeptide binding]; other site 290340005161 dimer interface [polypeptide binding]; other site 290340005162 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 290340005163 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 290340005164 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290340005165 Clp amino terminal domain; Region: Clp_N; pfam02861 290340005166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005167 Walker A motif; other site 290340005168 ATP binding site [chemical binding]; other site 290340005169 Walker B motif; other site 290340005170 arginine finger; other site 290340005171 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 290340005172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005173 Walker A motif; other site 290340005174 ATP binding site [chemical binding]; other site 290340005175 Walker B motif; other site 290340005176 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290340005177 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290340005178 thioredoxin 2; Provisional; Region: PRK10996 290340005179 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340005180 catalytic residues [active] 290340005181 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340005182 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340005183 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340005184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005186 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005189 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005190 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340005191 TM-ABC transporter signature motif; other site 290340005192 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340005193 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340005194 ligand binding site [chemical binding]; other site 290340005195 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340005196 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005197 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340005198 AP (apurinic/apyrimidinic) site pocket; other site 290340005199 DNA interaction; other site 290340005200 Metal-binding active site; metal-binding site 290340005201 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340005202 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340005203 Walker A/P-loop; other site 290340005204 ATP binding site [chemical binding]; other site 290340005205 Q-loop/lid; other site 290340005206 ABC transporter signature motif; other site 290340005207 Walker B; other site 290340005208 D-loop; other site 290340005209 H-loop/switch region; other site 290340005210 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340005211 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005212 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340005213 Metal-binding active site; metal-binding site 290340005214 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290340005215 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290340005216 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290340005217 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290340005218 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340005219 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 290340005220 Fic/DOC family; Region: Fic; cl00960 290340005221 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290340005222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340005223 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 290340005224 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340005225 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340005226 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340005227 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 290340005228 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340005229 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340005230 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340005231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005232 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290340005233 NAD(P) binding site [chemical binding]; other site 290340005234 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 290340005235 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 290340005236 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 290340005237 dimer interface [polypeptide binding]; other site 290340005238 active site 290340005239 catalytic residue [active] 290340005240 metal binding site [ion binding]; metal-binding site 290340005241 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 290340005242 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005244 DNA-binding site [nucleotide binding]; DNA binding site 290340005245 UTRA domain; Region: UTRA; cl01230 290340005246 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340005247 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340005248 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 290340005249 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 290340005250 active site 290340005251 catalytic site [active] 290340005252 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340005253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340005254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340005255 DNA binding residues [nucleotide binding] 290340005256 Putative zinc-finger; Region: zf-HC2; cl15806 290340005257 large tegument protein UL36; Provisional; Region: PHA03247 290340005258 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340005259 TPP-binding site [chemical binding]; other site 290340005260 transketolase; Reviewed; Region: PRK05899 290340005261 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 290340005262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005263 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290340005264 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 290340005265 tetramer interface [polypeptide binding]; other site 290340005266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005267 catalytic residue [active] 290340005268 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290340005269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005270 Walker A/P-loop; other site 290340005271 ATP binding site [chemical binding]; other site 290340005272 Q-loop/lid; other site 290340005273 ABC transporter signature motif; other site 290340005274 Walker B; other site 290340005275 D-loop; other site 290340005276 H-loop/switch region; other site 290340005277 TOBE domain; Region: TOBE_2; cl01440 290340005278 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290340005279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340005280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005281 dimer interface [polypeptide binding]; other site 290340005282 conserved gate region; other site 290340005283 putative PBP binding loops; other site 290340005284 ABC-ATPase subunit interface; other site 290340005285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340005286 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005288 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340005289 putative substrate translocation pore; other site 290340005290 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 290340005291 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 290340005292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290340005293 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 290340005294 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290340005295 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 290340005296 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 290340005297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290340005298 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290340005299 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290340005300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340005301 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 290340005302 NAD(P) binding site [chemical binding]; other site 290340005303 catalytic residues [active] 290340005304 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340005305 homotrimer interaction site [polypeptide binding]; other site 290340005306 putative active site [active] 290340005307 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340005308 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 290340005309 FMN-binding pocket [chemical binding]; other site 290340005310 flavin binding motif; other site 290340005311 phosphate binding motif [ion binding]; other site 290340005312 beta-alpha-beta structure motif; other site 290340005313 NAD binding pocket [chemical binding]; other site 290340005314 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340005315 catalytic loop [active] 290340005316 iron binding site [ion binding]; other site 290340005317 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340005318 active site 290340005319 metal binding site [ion binding]; metal-binding site 290340005320 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 290340005321 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 290340005322 putative active site [active] 290340005323 Mn binding site [ion binding]; other site 290340005324 putative oligomer interface [polypeptide binding]; other site 290340005325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340005326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340005327 classical (c) SDRs; Region: SDR_c; cd05233 290340005328 NAD(P) binding site [chemical binding]; other site 290340005329 active site 290340005330 short chain dehydrogenase; Provisional; Region: PRK07062 290340005331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005332 NAD(P) binding site [chemical binding]; other site 290340005333 active site 290340005334 hypothetical protein; Provisional; Region: PRK07064 290340005335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340005336 PYR/PP interface [polypeptide binding]; other site 290340005337 dimer interface [polypeptide binding]; other site 290340005338 TPP binding site [chemical binding]; other site 290340005339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340005340 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340005341 TPP-binding site [chemical binding]; other site 290340005342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340005343 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340005344 iron-sulfur cluster [ion binding]; other site 290340005345 [2Fe-2S] cluster binding site [ion binding]; other site 290340005346 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340005347 hydrophobic ligand binding site; other site 290340005348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340005349 Helix-turn-helix domains; Region: HTH; cl00088 290340005350 Helix-turn-helix domains; Region: HTH; cl00088 290340005351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005352 Domain of unknown function DUF108; Region: DUF108; pfam01958 290340005353 hypothetical protein; Provisional; Region: PRK06062 290340005354 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340005355 inhibitor-cofactor binding pocket; inhibition site 290340005356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005357 catalytic residue [active] 290340005358 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340005359 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340005360 Helix-turn-helix domains; Region: HTH; cl00088 290340005361 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340005362 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340005363 tetrameric interface [polypeptide binding]; other site 290340005364 NAD binding site [chemical binding]; other site 290340005365 catalytic residues [active] 290340005366 mycothione reductase; Region: mycothione_red; TIGR03452 290340005367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340005368 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340005369 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 290340005370 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 290340005371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340005372 catalytic core [active] 290340005373 stage V sporulation protein K; Region: spore_V_K; TIGR02881 290340005374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005375 Walker A motif; other site 290340005376 ATP binding site [chemical binding]; other site 290340005377 Walker B motif; other site 290340005378 arginine finger; other site 290340005379 glyoxylate reductase; Reviewed; Region: PRK13243 290340005380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005381 aspartate aminotransferase; Provisional; Region: PRK05764 290340005382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340005383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005384 homodimer interface [polypeptide binding]; other site 290340005385 catalytic residue [active] 290340005386 Protein of unknown function (DUF808); Region: DUF808; cl01002 290340005387 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290340005388 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290340005389 potential catalytic triad [active] 290340005390 conserved cys residue [active] 290340005391 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340005392 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340005393 DNA binding site [nucleotide binding] 290340005394 domain linker motif; other site 290340005395 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340005396 putative dimerization interface [polypeptide binding]; other site 290340005397 putative ligand binding site [chemical binding]; other site 290340005398 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 290340005399 substrate binding site [chemical binding]; other site 290340005400 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340005401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340005402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005403 dimer interface [polypeptide binding]; other site 290340005404 conserved gate region; other site 290340005405 putative PBP binding loops; other site 290340005406 ABC-ATPase subunit interface; other site 290340005407 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340005408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005409 dimer interface [polypeptide binding]; other site 290340005410 conserved gate region; other site 290340005411 putative PBP binding loops; other site 290340005412 ABC-ATPase subunit interface; other site 290340005413 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290340005414 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340005415 Walker A/P-loop; other site 290340005416 ATP binding site [chemical binding]; other site 290340005417 Q-loop/lid; other site 290340005418 ABC transporter signature motif; other site 290340005419 Walker B; other site 290340005420 D-loop; other site 290340005421 H-loop/switch region; other site 290340005422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340005423 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 290340005424 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340005425 Walker A/P-loop; other site 290340005426 ATP binding site [chemical binding]; other site 290340005427 Q-loop/lid; other site 290340005428 ABC transporter signature motif; other site 290340005429 Walker B; other site 290340005430 D-loop; other site 290340005431 H-loop/switch region; other site 290340005432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340005433 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340005434 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340005435 substrate binding [chemical binding]; other site 290340005436 active site 290340005437 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340005438 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 290340005439 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340005440 substrate binding [chemical binding]; other site 290340005441 active site 290340005442 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340005443 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340005444 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340005445 putative substrate binding site [chemical binding]; other site 290340005446 putative ATP binding site [chemical binding]; other site 290340005447 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340005448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005449 Walker A/P-loop; other site 290340005450 ATP binding site [chemical binding]; other site 290340005451 Q-loop/lid; other site 290340005452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005453 ABC transporter signature motif; other site 290340005454 ABC transporter signature motif; other site 290340005455 Walker B; other site 290340005456 Walker B; other site 290340005457 D-loop; other site 290340005458 D-loop; other site 290340005459 H-loop/switch region; other site 290340005460 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340005461 ABC-ATPase subunit interface; other site 290340005462 dimer interface [polypeptide binding]; other site 290340005463 putative PBP binding regions; other site 290340005464 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340005465 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290340005466 intersubunit interface [polypeptide binding]; other site 290340005467 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 290340005468 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 290340005469 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 290340005470 PrpF protein; Region: PrpF; pfam04303 290340005471 Helix-turn-helix domains; Region: HTH; cl00088 290340005472 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 290340005473 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340005474 putative dimerization interface [polypeptide binding]; other site 290340005475 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 290340005476 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340005477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340005478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005479 dimer interface [polypeptide binding]; other site 290340005480 conserved gate region; other site 290340005481 putative PBP binding loops; other site 290340005482 ABC-ATPase subunit interface; other site 290340005483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005484 dimer interface [polypeptide binding]; other site 290340005485 conserved gate region; other site 290340005486 putative PBP binding loops; other site 290340005487 ABC-ATPase subunit interface; other site 290340005488 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340005489 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340005490 Walker A/P-loop; other site 290340005491 ATP binding site [chemical binding]; other site 290340005492 Q-loop/lid; other site 290340005493 ABC transporter signature motif; other site 290340005494 Walker B; other site 290340005495 D-loop; other site 290340005496 H-loop/switch region; other site 290340005497 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340005498 Walker A/P-loop; other site 290340005499 ATP binding site [chemical binding]; other site 290340005500 Q-loop/lid; other site 290340005501 ABC transporter signature motif; other site 290340005502 Walker B; other site 290340005503 D-loop; other site 290340005504 H-loop/switch region; other site 290340005505 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290340005506 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340005507 putative di-iron ligands [ion binding]; other site 290340005508 GAF domain; Region: GAF; cl15785 290340005509 ANTAR domain; Region: ANTAR; cl04297 290340005510 GAF domain; Region: GAF_2; pfam13185 290340005511 GAF domain; Region: GAF; cl15785 290340005512 ANTAR domain; Region: ANTAR; cl04297 290340005513 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 290340005514 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290340005515 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340005516 substrate binding site [chemical binding]; other site 290340005517 ATP binding site [chemical binding]; other site 290340005518 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 290340005519 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340005520 PYR/PP interface [polypeptide binding]; other site 290340005521 dimer interface [polypeptide binding]; other site 290340005522 TPP binding site [chemical binding]; other site 290340005523 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340005524 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 290340005525 TPP-binding site; other site 290340005526 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340005527 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340005528 tetrameric interface [polypeptide binding]; other site 290340005529 NAD binding site [chemical binding]; other site 290340005530 catalytic residues [active] 290340005531 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005534 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005535 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340005536 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 290340005537 putative oxidoreductase; Provisional; Region: PRK11579 290340005538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005539 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005541 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005542 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340005543 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340005544 DNA binding site [nucleotide binding] 290340005545 domain linker motif; other site 290340005546 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340005547 ligand binding site [chemical binding]; other site 290340005548 dimerization interface [polypeptide binding]; other site 290340005549 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 290340005550 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340005551 putative ligand binding site [chemical binding]; other site 290340005552 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340005553 TM-ABC transporter signature motif; other site 290340005554 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340005555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005556 Walker A/P-loop; other site 290340005557 ATP binding site [chemical binding]; other site 290340005558 Q-loop/lid; other site 290340005559 ABC transporter signature motif; other site 290340005560 Walker B; other site 290340005561 D-loop; other site 290340005562 H-loop/switch region; other site 290340005563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005565 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005566 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005570 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005573 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340005574 KduI/IolB family; Region: KduI; cl01508 290340005575 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005577 DNA-binding site [nucleotide binding]; DNA binding site 290340005578 UTRA domain; Region: UTRA; cl01230 290340005579 ChaB; Region: ChaB; cl01887 290340005580 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 290340005581 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340005582 active site 290340005583 haloalkane dehalogenase; Provisional; Region: PRK03204 290340005584 peptide synthase; Provisional; Region: PRK09274 290340005585 AMP-binding enzyme; Region: AMP-binding; cl15778 290340005586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340005587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005588 NAD(P) binding site [chemical binding]; other site 290340005589 active site 290340005590 amino acid transporter; Region: 2A0306; TIGR00909 290340005591 Spore germination protein; Region: Spore_permease; cl15802 290340005592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340005593 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 290340005594 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290340005595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005596 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290340005597 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290340005598 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340005599 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 290340005600 nucleotide binding site [chemical binding]; other site 290340005601 pyruvate dehydrogenase; Provisional; Region: PRK06546 290340005602 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290340005603 PYR/PP interface [polypeptide binding]; other site 290340005604 dimer interface [polypeptide binding]; other site 290340005605 tetramer interface [polypeptide binding]; other site 290340005606 TPP binding site [chemical binding]; other site 290340005607 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340005608 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290340005609 TPP-binding site [chemical binding]; other site 290340005610 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290340005611 excinuclease ABC subunit A; Provisional; Region: PRK00635 290340005612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005613 ABC transporter signature motif; other site 290340005614 Walker B; other site 290340005615 D-loop; other site 290340005616 H-loop/switch region; other site 290340005617 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 290340005618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340005619 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340005620 homotrimer interaction site [polypeptide binding]; other site 290340005621 putative active site [active] 290340005622 RF-1 domain; Region: RF-1; cl02875 290340005623 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340005624 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340005625 Walker A/P-loop; other site 290340005626 ATP binding site [chemical binding]; other site 290340005627 Q-loop/lid; other site 290340005628 ABC transporter signature motif; other site 290340005629 Walker B; other site 290340005630 D-loop; other site 290340005631 H-loop/switch region; other site 290340005632 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290340005633 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340005634 siderophore binding site; other site 290340005635 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340005636 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340005637 putative PBP binding regions; other site 290340005638 ABC-ATPase subunit interface; other site 290340005639 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340005640 dimer interface [polypeptide binding]; other site 290340005641 putative PBP binding regions; other site 290340005642 ABC-ATPase subunit interface; other site 290340005643 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340005644 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 290340005645 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290340005646 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 290340005647 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 290340005648 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290340005649 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005651 putative substrate translocation pore; other site 290340005652 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340005653 metal ion-dependent adhesion site (MIDAS); other site 290340005654 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340005655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005656 SWIM zinc finger; Region: SWIM; cl15408 290340005657 phenol 2-monooxygenase; Provisional; Region: PRK08294 290340005658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005659 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 290340005660 dimer interface [polypeptide binding]; other site 290340005661 5'-3' exonuclease; Region: 53EXOc; smart00475 290340005662 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290340005663 active site 290340005664 metal binding site 1 [ion binding]; metal-binding site 290340005665 putative 5' ssDNA interaction site; other site 290340005666 metal binding site 3; metal-binding site 290340005667 metal binding site 2 [ion binding]; metal-binding site 290340005668 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290340005669 putative DNA binding site [nucleotide binding]; other site 290340005670 putative metal binding site [ion binding]; other site 290340005671 YCII-related domain; Region: YCII; cl00999 290340005672 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 290340005673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340005674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340005675 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340005676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340005677 active site 290340005678 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340005679 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290340005680 putative NAD(P) binding site [chemical binding]; other site 290340005681 putative substrate binding site [chemical binding]; other site 290340005682 catalytic Zn binding site [ion binding]; other site 290340005683 structural Zn binding site [ion binding]; other site 290340005684 dimer interface [polypeptide binding]; other site 290340005685 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 290340005686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340005687 putative Mg++ binding site [ion binding]; other site 290340005688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005689 Helicase associated domain (HA2); Region: HA2; cl04503 290340005690 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 290340005691 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340005692 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340005693 active site 290340005694 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340005695 Spore germination protein; Region: Spore_permease; cl15802 290340005696 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 290340005697 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 290340005698 elongation factor G; Reviewed; Region: PRK12740 290340005699 G1 box; other site 290340005700 putative GEF interaction site [polypeptide binding]; other site 290340005701 GTP/Mg2+ binding site [chemical binding]; other site 290340005702 Switch I region; other site 290340005703 G2 box; other site 290340005704 G3 box; other site 290340005705 Switch II region; other site 290340005706 G4 box; other site 290340005707 G5 box; other site 290340005708 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290340005709 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290340005710 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290340005711 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 290340005712 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 290340005713 nucleotide binding site [chemical binding]; other site 290340005714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340005715 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290340005716 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340005717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340005718 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 290340005719 Walker A/P-loop; other site 290340005720 ATP binding site [chemical binding]; other site 290340005721 Q-loop/lid; other site 290340005722 ABC transporter signature motif; other site 290340005723 Walker B; other site 290340005724 D-loop; other site 290340005725 H-loop/switch region; other site 290340005726 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 290340005727 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340005728 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005730 DNA-binding site [nucleotide binding]; DNA binding site 290340005731 UTRA domain; Region: UTRA; cl01230 290340005732 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 290340005733 PaaX-like protein; Region: PaaX; pfam07848 290340005734 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 290340005735 kynureninase; Region: kynureninase; TIGR01814 290340005736 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340005737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340005738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340005739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340005740 catalytic residue [active] 290340005741 catalytic residue [active] 290340005742 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 290340005743 Phosphate transporter family; Region: PHO4; cl00396 290340005744 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340005745 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290340005746 CoenzymeA binding site [chemical binding]; other site 290340005747 subunit interaction site [polypeptide binding]; other site 290340005748 PHB binding site; other site 290340005749 DNA polymerase I; Provisional; Region: PRK05755 290340005750 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290340005751 active site 290340005752 putative 5' ssDNA interaction site; other site 290340005753 metal binding site 3; metal-binding site 290340005754 metal binding site 1 [ion binding]; metal-binding site 290340005755 metal binding site 2 [ion binding]; metal-binding site 290340005756 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290340005757 putative DNA binding site [nucleotide binding]; other site 290340005758 putative metal binding site [ion binding]; other site 290340005759 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 290340005760 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290340005761 active site 290340005762 DNA binding site [nucleotide binding] 290340005763 catalytic site [active] 290340005764 hypothetical protein; Provisional; Region: PRK01346 290340005765 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340005766 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 290340005767 NodB motif; other site 290340005768 putative active site [active] 290340005769 putative catalytic site [active] 290340005770 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 290340005771 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290340005772 RNA binding site [nucleotide binding]; other site 290340005773 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290340005774 RNA binding site [nucleotide binding]; other site 290340005775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290340005776 RNA binding site [nucleotide binding]; other site 290340005777 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290340005778 RNA binding site [nucleotide binding]; other site 290340005779 domain interface; other site 290340005780 Uncharacterized conserved protein [Function unknown]; Region: COG1739 290340005781 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 290340005782 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 290340005783 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 290340005784 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290340005785 CoA-binding site [chemical binding]; other site 290340005786 ATP-binding [chemical binding]; other site 290340005787 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 290340005788 excinuclease ABC subunit B; Provisional; Region: PRK05298 290340005789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340005791 nucleotide binding region [chemical binding]; other site 290340005792 ATP-binding site [chemical binding]; other site 290340005793 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290340005794 UvrB/uvrC motif; Region: UVR; pfam02151 290340005795 Integral membrane protein TerC family; Region: TerC; cl10468 290340005796 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340005797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340005798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340005799 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340005800 Coenzyme A binding pocket [chemical binding]; other site 290340005801 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340005802 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 290340005803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340005804 ATP binding site [chemical binding]; other site 290340005805 putative Mg++ binding site [ion binding]; other site 290340005806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340005807 nucleotide binding region [chemical binding]; other site 290340005808 ATP-binding site [chemical binding]; other site 290340005809 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 290340005810 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 290340005811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340005812 S-adenosylmethionine binding site [chemical binding]; other site 290340005813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005814 DNA-binding site [nucleotide binding]; DNA binding site 290340005815 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290340005816 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290340005817 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290340005818 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 290340005819 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290340005820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340005821 active site 290340005822 motif I; other site 290340005823 motif II; other site 290340005824 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340005825 putative acyl-acceptor binding pocket; other site 290340005826 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 290340005827 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290340005828 GIY-YIG motif/motif A; other site 290340005829 active site 290340005830 catalytic site [active] 290340005831 putative DNA binding site [nucleotide binding]; other site 290340005832 metal binding site [ion binding]; metal-binding site 290340005833 UvrB/uvrC motif; Region: UVR; pfam02151 290340005834 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290340005835 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340005836 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 290340005837 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 290340005838 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 290340005839 putative substrate binding pocket [chemical binding]; other site 290340005840 dimer interface [polypeptide binding]; other site 290340005841 phosphate binding site [ion binding]; other site 290340005842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 290340005843 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 290340005844 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 290340005845 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290340005846 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290340005847 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 290340005848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005849 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290340005850 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290340005851 Phosphoglycerate kinase; Region: PGK; pfam00162 290340005852 substrate binding site [chemical binding]; other site 290340005853 hinge regions; other site 290340005854 ADP binding site [chemical binding]; other site 290340005855 catalytic site [active] 290340005856 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290340005857 substrate binding site [chemical binding]; other site 290340005858 dimer interface [polypeptide binding]; other site 290340005859 catalytic triad [active] 290340005860 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 290340005861 putative active site [active] 290340005862 opcA protein; Region: OpcA; TIGR00534 290340005863 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 290340005864 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290340005865 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290340005866 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290340005867 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 290340005868 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290340005869 active site 290340005870 dimer interface [polypeptide binding]; other site 290340005871 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340005872 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 290340005873 putative active site [active] 290340005874 transaldolase; Provisional; Region: PRK03903 290340005875 catalytic residue [active] 290340005876 transketolase; Reviewed; Region: PRK05899 290340005877 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340005878 TPP-binding site [chemical binding]; other site 290340005879 dimer interface [polypeptide binding]; other site 290340005880 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340005881 PYR/PP interface [polypeptide binding]; other site 290340005882 dimer interface [polypeptide binding]; other site 290340005883 TPP binding site [chemical binding]; other site 290340005884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005885 UbiA prenyltransferase family; Region: UbiA; cl00337 290340005886 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 290340005887 putative active site [active] 290340005888 putative metal-binding site [ion binding]; other site 290340005889 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 290340005890 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340005891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340005892 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 290340005893 Walker A/P-loop; other site 290340005894 ATP binding site [chemical binding]; other site 290340005895 Q-loop/lid; other site 290340005896 ABC transporter signature motif; other site 290340005897 Walker B; other site 290340005898 D-loop; other site 290340005899 H-loop/switch region; other site 290340005900 Predicted transcriptional regulator [Transcription]; Region: COG2345 290340005901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340005902 putative DNA binding site [nucleotide binding]; other site 290340005903 putative Zn2+ binding site [ion binding]; other site 290340005904 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 290340005905 FeS assembly protein SufB; Region: sufB; TIGR01980 290340005906 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 290340005907 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 290340005908 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 290340005909 [2Fe-2S] cluster binding site [ion binding]; other site 290340005910 FeS assembly ATPase SufC; Region: sufC; TIGR01978 290340005911 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 290340005912 Walker A/P-loop; other site 290340005913 ATP binding site [chemical binding]; other site 290340005914 Q-loop/lid; other site 290340005915 ABC transporter signature motif; other site 290340005916 Walker B; other site 290340005917 D-loop; other site 290340005918 H-loop/switch region; other site 290340005919 Domain of unknown function DUF59; Region: DUF59; cl00941 290340005920 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 290340005921 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 290340005922 AMP-binding enzyme; Region: AMP-binding; cl15778 290340005923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340005924 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290340005925 dimer interface [polypeptide binding]; other site 290340005926 active site 290340005927 Cobalt transport protein; Region: CbiQ; cl00463 290340005928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005929 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340005930 Walker A/P-loop; other site 290340005931 ATP binding site [chemical binding]; other site 290340005932 Q-loop/lid; other site 290340005933 ABC transporter signature motif; other site 290340005934 Walker B; other site 290340005935 D-loop; other site 290340005936 H-loop/switch region; other site 290340005937 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 290340005938 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340005939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340005940 Walker A/P-loop; other site 290340005941 ATP binding site [chemical binding]; other site 290340005942 Q-loop/lid; other site 290340005943 ABC transporter signature motif; other site 290340005944 Walker B; other site 290340005945 D-loop; other site 290340005946 H-loop/switch region; other site 290340005947 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340005948 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 290340005949 putative deacylase active site [active] 290340005950 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340005951 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 290340005952 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290340005953 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290340005954 NAD(P) binding site [chemical binding]; other site 290340005955 homotetramer interface [polypeptide binding]; other site 290340005956 homodimer interface [polypeptide binding]; other site 290340005957 active site 290340005958 short chain dehydrogenase; Provisional; Region: PRK12937 290340005959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005960 NAD(P) binding site [chemical binding]; other site 290340005961 active site 290340005962 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340005963 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290340005964 Walker A/P-loop; other site 290340005965 ATP binding site [chemical binding]; other site 290340005966 Q-loop/lid; other site 290340005967 ABC transporter signature motif; other site 290340005968 Walker B; other site 290340005969 D-loop; other site 290340005970 H-loop/switch region; other site 290340005971 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290340005972 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290340005973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340005974 motif II; other site 290340005975 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340005976 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 290340005977 Walker A/P-loop; other site 290340005978 ATP binding site [chemical binding]; other site 290340005979 Q-loop/lid; other site 290340005980 ABC transporter signature motif; other site 290340005981 Walker B; other site 290340005982 D-loop; other site 290340005983 H-loop/switch region; other site 290340005984 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 290340005985 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340005986 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290340005987 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290340005988 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 290340005989 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290340005990 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290340005991 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290340005992 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290340005993 Zn binding site [ion binding]; other site 290340005994 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 290340005995 Uncharacterized conserved protein [Function unknown]; Region: COG2308 290340005996 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 290340005997 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340005998 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 290340005999 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 290340006000 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 290340006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006002 NAD(P) binding site [chemical binding]; other site 290340006003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006004 active site 290340006005 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 290340006006 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 290340006007 ligand binding site; other site 290340006008 oligomer interface; other site 290340006009 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290340006010 sulfate 1 binding site; other site 290340006011 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 290340006012 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290340006013 acyl-coenzyme A oxidase; Region: PLN02636 290340006014 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340006015 active site 290340006016 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 290340006017 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340006018 dimer interface [polypeptide binding]; other site 290340006019 active site 290340006020 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 290340006021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006022 NAD(P) binding site [chemical binding]; other site 290340006023 active site 290340006024 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340006025 active site 2 [active] 290340006026 active site 1 [active] 290340006027 hypothetical protein; Provisional; Region: PRK07906 290340006028 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 290340006029 putative metal binding site [ion binding]; other site 290340006030 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340006031 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340006032 active site 290340006033 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340006034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006035 Bacterial sugar transferase; Region: Bac_transf; cl00939 290340006036 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340006037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340006039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006040 NAD(P) binding site [chemical binding]; other site 290340006041 active site 290340006042 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290340006043 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290340006044 inhibitor-cofactor binding pocket; inhibition site 290340006045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340006046 catalytic residue [active] 290340006047 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 290340006048 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 290340006049 putative trimer interface [polypeptide binding]; other site 290340006050 putative CoA binding site [chemical binding]; other site 290340006051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340006052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340006053 MatE; Region: MatE; cl10513 290340006054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340006055 active site 290340006056 O-Antigen ligase; Region: Wzy_C; cl04850 290340006057 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290340006058 putative ADP-binding pocket [chemical binding]; other site 290340006059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340006060 active site 290340006061 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290340006062 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340006063 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290340006064 Probable Catalytic site; other site 290340006065 metal-binding site 290340006066 Cupin domain; Region: Cupin_2; cl09118 290340006067 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290340006068 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 290340006069 NADP binding site [chemical binding]; other site 290340006070 active site 290340006071 putative substrate binding site [chemical binding]; other site 290340006072 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290340006073 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290340006074 NAD binding site [chemical binding]; other site 290340006075 substrate binding site [chemical binding]; other site 290340006076 homodimer interface [polypeptide binding]; other site 290340006077 active site 290340006078 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290340006079 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290340006080 substrate binding site; other site 290340006081 tetramer interface; other site 290340006082 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340006083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340006084 active site 290340006085 catalytic tetrad [active] 290340006086 Bacitracin resistance protein BacA; Region: BacA; cl00858 290340006087 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 290340006088 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006089 active site 290340006090 HIGH motif; other site 290340006091 nucleotide binding site [chemical binding]; other site 290340006092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006093 active site 290340006094 KMSKS motif; other site 290340006095 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290340006096 tRNA binding surface [nucleotide binding]; other site 290340006097 anticodon binding site; other site 290340006098 PAC2 family; Region: PAC2; cl00847 290340006099 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290340006100 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340006101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340006102 motif II; other site 290340006103 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 290340006104 active site 290340006105 putative substrate binding region [chemical binding]; other site 290340006106 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 290340006107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006108 proteasome ATPase; Region: pup_AAA; TIGR03689 290340006109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006110 Walker A motif; other site 290340006111 ATP binding site [chemical binding]; other site 290340006112 Walker B motif; other site 290340006113 arginine finger; other site 290340006114 Pup-ligase protein; Region: Pup_ligase; cl15463 290340006115 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290340006116 active site 290340006117 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 290340006118 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290340006119 active site 290340006120 Pup-ligase protein; Region: Pup_ligase; cl15463 290340006121 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 290340006122 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 290340006123 WYL domain; Region: WYL; cl14852 290340006124 Predicted transcriptional regulator [Transcription]; Region: COG2378 290340006125 WYL domain; Region: WYL; cl14852 290340006126 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290340006127 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 290340006128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340006129 ATP binding site [chemical binding]; other site 290340006130 putative Mg++ binding site [ion binding]; other site 290340006131 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 290340006132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340006133 nucleotide binding region [chemical binding]; other site 290340006134 ATP-binding site [chemical binding]; other site 290340006135 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 290340006136 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 290340006137 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340006138 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340006139 active site 290340006140 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290340006141 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 290340006142 Ligand binding site; other site 290340006143 Putative Catalytic site; other site 290340006144 DXD motif; other site 290340006145 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 290340006146 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290340006147 HflK protein; Region: hflK; TIGR01933 290340006148 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 290340006149 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 290340006150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006151 S-adenosylmethionine binding site [chemical binding]; other site 290340006152 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290340006153 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290340006154 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340006155 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340006156 active site 290340006157 catalytic residues [active] 290340006158 metal binding site [ion binding]; metal-binding site 290340006159 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340006160 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290340006161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006163 S-adenosylmethionine binding site [chemical binding]; other site 290340006164 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 290340006165 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 290340006166 malonyl-CoA binding site [chemical binding]; other site 290340006167 dimer interface [polypeptide binding]; other site 290340006168 active site 290340006169 product binding site; other site 290340006170 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290340006171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006172 ABC transporter signature motif; other site 290340006173 Walker B; other site 290340006174 D-loop; other site 290340006175 H-loop/switch region; other site 290340006176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006177 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 290340006178 Walker A/P-loop; other site 290340006179 ATP binding site [chemical binding]; other site 290340006180 Q-loop/lid; other site 290340006181 ABC transporter signature motif; other site 290340006182 Walker B; other site 290340006183 D-loop; other site 290340006184 H-loop/switch region; other site 290340006185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340006186 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290340006187 dimer interface [polypeptide binding]; other site 290340006188 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340006189 active site 290340006190 metal binding site [ion binding]; metal-binding site 290340006191 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 290340006192 Helix-turn-helix domains; Region: HTH; cl00088 290340006193 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290340006194 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290340006195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290340006196 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 290340006197 Subunit I/III interface [polypeptide binding]; other site 290340006198 Cytochrome c; Region: Cytochrom_C; cl11414 290340006199 Cytochrome c; Region: Cytochrom_C; cl11414 290340006200 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290340006201 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290340006202 iron-sulfur cluster [ion binding]; other site 290340006203 [2Fe-2S] cluster binding site [ion binding]; other site 290340006204 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 290340006205 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290340006206 heme bH binding site [chemical binding]; other site 290340006207 intrachain domain interface; other site 290340006208 heme bL binding site [chemical binding]; other site 290340006209 interchain domain interface [polypeptide binding]; other site 290340006210 Qo binding site; other site 290340006211 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340006212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340006213 DNA-binding site [nucleotide binding]; DNA binding site 290340006214 UTRA domain; Region: UTRA; cl01230 290340006215 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 290340006216 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 290340006217 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 290340006218 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 290340006219 D-pathway; other site 290340006220 Putative ubiquinol binding site [chemical binding]; other site 290340006221 Low-spin heme (heme b) binding site [chemical binding]; other site 290340006222 Putative water exit pathway; other site 290340006223 Binuclear center (heme o3/CuB) [ion binding]; other site 290340006224 K-pathway; other site 290340006225 Putative proton exit pathway; other site 290340006226 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 290340006227 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 290340006228 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340006229 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 290340006230 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 290340006231 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 290340006232 active site 290340006233 metal binding site [ion binding]; metal-binding site 290340006234 dimer interface [polypeptide binding]; other site 290340006235 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 290340006236 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 290340006237 quinone interaction residues [chemical binding]; other site 290340006238 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 290340006239 active site 290340006240 catalytic residues [active] 290340006241 FMN binding site [chemical binding]; other site 290340006242 substrate binding site [chemical binding]; other site 290340006243 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290340006244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340006245 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290340006246 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290340006247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340006248 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290340006249 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290340006250 catalytic residue [active] 290340006251 putative FPP diphosphate binding site; other site 290340006252 putative FPP binding hydrophobic cleft; other site 290340006253 dimer interface [polypeptide binding]; other site 290340006254 putative IPP diphosphate binding site; other site 290340006255 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290340006256 Recombination protein O N terminal; Region: RecO_N; cl15812 290340006257 Recombination protein O C terminal; Region: RecO_C; pfam02565 290340006258 2-isopropylmalate synthase; Validated; Region: PRK03739 290340006259 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 290340006260 active site 290340006261 catalytic residues [active] 290340006262 metal binding site [ion binding]; metal-binding site 290340006263 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 290340006264 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 290340006265 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 290340006266 active site 290340006267 Zn binding site [ion binding]; other site 290340006268 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 290340006269 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340006270 GTPase Era; Reviewed; Region: era; PRK00089 290340006271 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290340006272 G1 box; other site 290340006273 GTP/Mg2+ binding site [chemical binding]; other site 290340006274 Switch I region; other site 290340006275 G2 box; other site 290340006276 Switch II region; other site 290340006277 G3 box; other site 290340006278 G4 box; other site 290340006279 G5 box; other site 290340006280 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 290340006281 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340006282 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340006283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340006284 Transporter associated domain; Region: CorC_HlyC; cl08393 290340006285 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 290340006286 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290340006287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006288 Sporulation and spore germination; Region: Germane; cl11253 290340006289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 290340006290 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 290340006291 chaperone protein DnaJ; Provisional; Region: PRK14278 290340006292 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340006293 HSP70 interaction site [polypeptide binding]; other site 290340006294 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290340006295 Zn binding sites [ion binding]; other site 290340006296 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290340006297 dimer interface [polypeptide binding]; other site 290340006298 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 290340006299 Helix-turn-helix domains; Region: HTH; cl00088 290340006300 HrcA protein C terminal domain; Region: HrcA; pfam01628 290340006301 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 290340006302 Tic20-like protein; Region: Tic20; pfam09685 290340006303 coproporphyrinogen III oxidase; Validated; Region: PRK05628 290340006304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340006305 FeS/SAM binding site; other site 290340006306 GTP-binding protein LepA; Provisional; Region: PRK05433 290340006307 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290340006308 G1 box; other site 290340006309 putative GEF interaction site [polypeptide binding]; other site 290340006310 GTP/Mg2+ binding site [chemical binding]; other site 290340006311 Switch I region; other site 290340006312 G2 box; other site 290340006313 G3 box; other site 290340006314 Switch II region; other site 290340006315 G4 box; other site 290340006316 G5 box; other site 290340006317 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 290340006318 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290340006319 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290340006320 PemK-like protein; Region: PemK; cl00995 290340006321 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 290340006322 hypothetical protein; Reviewed; Region: PRK07914 290340006323 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290340006324 Competence protein; Region: Competence; cl00471 290340006325 SLBB domain; Region: SLBB; pfam10531 290340006326 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290340006327 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 290340006328 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290340006329 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290340006330 HIGH motif; other site 290340006331 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290340006332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006333 active site 290340006334 KMSKS motif; other site 290340006335 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290340006336 tRNA binding surface [nucleotide binding]; other site 290340006337 glycerol kinase; Provisional; Region: glpK; PRK00047 290340006338 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 290340006339 N- and C-terminal domain interface [polypeptide binding]; other site 290340006340 putative active site [active] 290340006341 putative MgATP binding site [chemical binding]; other site 290340006342 catalytic site [active] 290340006343 metal binding site [ion binding]; metal-binding site 290340006344 putative homotetramer interface [polypeptide binding]; other site 290340006345 putative glycerol binding site [chemical binding]; other site 290340006346 homodimer interface [polypeptide binding]; other site 290340006347 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290340006348 amphipathic channel; other site 290340006349 Asn-Pro-Ala signature motifs; other site 290340006350 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 290340006351 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 290340006352 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 290340006353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340006354 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340006355 active site 290340006356 catalytic tetrad [active] 290340006357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340006358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340006359 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290340006360 benzoate transport; Region: 2A0115; TIGR00895 290340006361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006362 putative substrate translocation pore; other site 290340006363 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340006364 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 290340006365 FMN-binding pocket [chemical binding]; other site 290340006366 flavin binding motif; other site 290340006367 phosphate binding motif [ion binding]; other site 290340006368 beta-alpha-beta structure motif; other site 290340006369 NAD binding pocket [chemical binding]; other site 290340006370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340006371 catalytic loop [active] 290340006372 iron binding site [ion binding]; other site 290340006373 Helix-turn-helix domains; Region: HTH; cl00088 290340006374 primosome assembly protein PriA; Provisional; Region: PRK14873 290340006375 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290340006376 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290340006377 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290340006378 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290340006379 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290340006380 Flavoprotein; Region: Flavoprotein; cl08021 290340006381 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 290340006382 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 290340006383 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290340006384 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290340006385 catalytic site [active] 290340006386 G-X2-G-X-G-K; other site 290340006387 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 290340006388 active site 290340006389 dimer interface [polypeptide binding]; other site 290340006390 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 290340006391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340006392 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340006393 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290340006394 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340006395 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340006396 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290340006397 IMP binding site; other site 290340006398 dimer interface [polypeptide binding]; other site 290340006399 interdomain contacts; other site 290340006400 partial ornithine binding site; other site 290340006401 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290340006402 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 290340006403 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290340006404 catalytic site [active] 290340006405 subunit interface [polypeptide binding]; other site 290340006406 dihydroorotase; Validated; Region: pyrC; PRK09357 290340006407 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340006408 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 290340006409 active site 290340006410 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 290340006411 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290340006412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340006414 active site 290340006415 Protease prsW family; Region: PrsW-protease; cl15823 290340006416 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290340006417 putative RNA binding site [nucleotide binding]; other site 290340006418 elongation factor P; Validated; Region: PRK00529 290340006419 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290340006420 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290340006421 RNA binding site [nucleotide binding]; other site 290340006422 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290340006423 RNA binding site [nucleotide binding]; other site 290340006424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290340006425 TPR motif; other site 290340006426 binding surface 290340006427 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290340006428 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290340006429 active site 290340006430 dimer interface [polypeptide binding]; other site 290340006431 metal binding site [ion binding]; metal-binding site 290340006432 shikimate kinase; Reviewed; Region: aroK; PRK00131 290340006433 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290340006434 ADP binding site [chemical binding]; other site 290340006435 magnesium binding site [ion binding]; other site 290340006436 putative shikimate binding site; other site 290340006437 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290340006438 Tetramer interface [polypeptide binding]; other site 290340006439 active site 290340006440 FMN-binding site [chemical binding]; other site 290340006441 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290340006442 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340006443 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340006444 shikimate binding site; other site 290340006445 NAD(P) binding site [chemical binding]; other site 290340006446 YceG-like family; Region: YceG; pfam02618 290340006447 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 290340006448 dimerization interface [polypeptide binding]; other site 290340006449 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 290340006450 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290340006451 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 290340006452 motif 1; other site 290340006453 active site 290340006454 motif 2; other site 290340006455 motif 3; other site 290340006456 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 290340006457 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290340006458 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290340006459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340006460 RNA binding surface [nucleotide binding]; other site 290340006461 recombination factor protein RarA; Reviewed; Region: PRK13342 290340006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006463 Walker A motif; other site 290340006464 ATP binding site [chemical binding]; other site 290340006465 Walker B motif; other site 290340006466 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290340006467 Predicted acetyltransferase [General function prediction only]; Region: COG3393 290340006468 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340006469 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290340006470 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290340006471 dimer interface [polypeptide binding]; other site 290340006472 anticodon binding site; other site 290340006473 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 290340006474 homodimer interface [polypeptide binding]; other site 290340006475 motif 1; other site 290340006476 active site 290340006477 motif 2; other site 290340006478 GAD domain; Region: GAD; pfam02938 290340006479 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290340006480 active site 290340006481 motif 3; other site 290340006482 histidyl-tRNA synthetase; Region: hisS; TIGR00442 290340006483 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 290340006484 dimer interface [polypeptide binding]; other site 290340006485 motif 1; other site 290340006486 active site 290340006487 motif 2; other site 290340006488 motif 3; other site 290340006489 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290340006490 anticodon binding site; other site 290340006491 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290340006492 active site 290340006493 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006494 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006495 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006496 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 290340006497 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 290340006498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290340006499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290340006500 synthetase active site [active] 290340006501 NTP binding site [chemical binding]; other site 290340006502 metal binding site [ion binding]; metal-binding site 290340006503 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290340006504 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290340006505 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290340006506 Protein export membrane protein; Region: SecD_SecF; cl14618 290340006507 Preprotein translocase subunit; Region: YajC; cl00806 290340006508 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290340006509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006510 Walker A motif; other site 290340006511 ATP binding site [chemical binding]; other site 290340006512 Walker B motif; other site 290340006513 arginine finger; other site 290340006514 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290340006515 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290340006516 RuvA N terminal domain; Region: RuvA_N; pfam01330 290340006517 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290340006518 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 290340006519 active site 290340006520 putative DNA-binding cleft [nucleotide binding]; other site 290340006521 dimer interface [polypeptide binding]; other site 290340006522 Transcriptional regulator; Region: Transcrip_reg; cl00361 290340006523 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 290340006524 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 290340006525 predicted active site [active] 290340006526 catalytic triad [active] 290340006527 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 290340006528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340006529 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 290340006530 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290340006531 catalytic triad [active] 290340006532 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 290340006533 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 290340006534 putative active site [active] 290340006535 putative metal binding site [ion binding]; other site 290340006536 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290340006537 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290340006538 active site 290340006539 multimer interface [polypeptide binding]; other site 290340006540 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290340006541 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 290340006542 nucleotide binding site/active site [active] 290340006543 HIT family signature motif; other site 290340006544 catalytic residue [active] 290340006545 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 290340006546 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 290340006547 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 290340006548 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290340006549 active site 290340006550 dimer interface [polypeptide binding]; other site 290340006551 motif 1; other site 290340006552 motif 2; other site 290340006553 motif 3; other site 290340006554 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290340006555 anticodon binding site; other site 290340006556 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 290340006557 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 290340006558 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290340006559 generic binding surface II; other site 290340006560 generic binding surface I; other site 290340006561 hypothetical protein; Provisional; Region: PRK06753 290340006562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006563 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 290340006564 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340006565 catalytic residues [active] 290340006566 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 290340006567 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340006568 NAD binding site [chemical binding]; other site 290340006569 catalytic Zn binding site [ion binding]; other site 290340006570 substrate binding site [chemical binding]; other site 290340006571 structural Zn binding site [ion binding]; other site 290340006572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340006573 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340006574 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340006575 putative molybdopterin cofactor binding site [chemical binding]; other site 290340006576 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340006577 putative molybdopterin cofactor binding site; other site 290340006578 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290340006579 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 290340006580 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340006581 FAD dependent oxidoreductase; Region: DAO; pfam01266 290340006582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006583 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340006584 iron-sulfur cluster [ion binding]; other site 290340006585 [2Fe-2S] cluster binding site [ion binding]; other site 290340006586 A new structural DNA glycosylase; Region: AlkD_like; cl11434 290340006587 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290340006588 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340006589 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340006590 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290340006591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340006592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006593 Walker A/P-loop; other site 290340006594 ATP binding site [chemical binding]; other site 290340006595 Q-loop/lid; other site 290340006596 ABC transporter signature motif; other site 290340006597 Walker B; other site 290340006598 D-loop; other site 290340006599 H-loop/switch region; other site 290340006600 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290340006601 Acyl transferase domain; Region: Acyl_transf_1; cl08282 290340006602 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290340006603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006604 NAD(P) binding site [chemical binding]; other site 290340006605 active site 290340006606 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290340006607 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290340006608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340006609 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340006610 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 290340006611 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290340006612 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290340006613 dimer interface [polypeptide binding]; other site 290340006614 active site 290340006615 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 290340006616 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340006617 active site 290340006618 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 290340006619 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290340006620 dimer interface [polypeptide binding]; other site 290340006621 putative radical transfer pathway; other site 290340006622 diiron center [ion binding]; other site 290340006623 tyrosyl radical; other site 290340006624 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 290340006625 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 290340006626 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290340006627 active site 290340006628 dimer interface [polypeptide binding]; other site 290340006629 catalytic residues [active] 290340006630 effector binding site; other site 290340006631 R2 peptide binding site; other site 290340006632 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340006633 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340006634 catalytic residues [active] 290340006635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340006636 Helix-turn-helix domains; Region: HTH; cl00088 290340006637 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340006638 putative dimerization interface [polypeptide binding]; other site 290340006639 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 290340006640 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290340006641 metal ion-dependent adhesion site (MIDAS); other site 290340006642 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340006643 metal ion-dependent adhesion site (MIDAS); other site 290340006644 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340006645 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340006646 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340006647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006648 Walker A motif; other site 290340006649 ATP binding site [chemical binding]; other site 290340006650 Walker B motif; other site 290340006651 arginine finger; other site 290340006652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340006653 dimer interface [polypeptide binding]; other site 290340006654 conserved gate region; other site 290340006655 putative PBP binding loops; other site 290340006656 ABC-ATPase subunit interface; other site 290340006657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340006658 dimer interface [polypeptide binding]; other site 290340006659 conserved gate region; other site 290340006660 putative PBP binding loops; other site 290340006661 ABC-ATPase subunit interface; other site 290340006662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340006663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340006664 Helix-turn-helix domains; Region: HTH; cl00088 290340006665 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340006666 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340006667 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 290340006668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006669 S-adenosylmethionine binding site [chemical binding]; other site 290340006670 Cupin domain; Region: Cupin_2; cl09118 290340006671 Oligomerisation domain; Region: Oligomerisation; cl00519 290340006672 DNA topoisomerase 2; Provisional; Region: PLN03237 290340006673 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290340006674 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290340006675 active site 290340006676 (T/H)XGH motif; other site 290340006677 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290340006678 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290340006679 putative catalytic cysteine [active] 290340006680 gamma-glutamyl kinase; Provisional; Region: PRK05429 290340006681 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290340006682 nucleotide binding site [chemical binding]; other site 290340006683 homotetrameric interface [polypeptide binding]; other site 290340006684 putative phosphate binding site [ion binding]; other site 290340006685 putative allosteric binding site; other site 290340006686 PUA domain; Region: PUA; cl00607 290340006687 GTPase CgtA; Reviewed; Region: obgE; PRK12296 290340006688 GTP1/OBG; Region: GTP1_OBG; pfam01018 290340006689 Obg GTPase; Region: Obg; cd01898 290340006690 G1 box; other site 290340006691 GTP/Mg2+ binding site [chemical binding]; other site 290340006692 Switch I region; other site 290340006693 G2 box; other site 290340006694 G3 box; other site 290340006695 Switch II region; other site 290340006696 G4 box; other site 290340006697 G5 box; other site 290340006698 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 290340006699 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 290340006700 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 290340006701 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 290340006702 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290340006703 dimer interface [polypeptide binding]; other site 290340006704 substrate binding site [chemical binding]; other site 290340006705 ATP binding site [chemical binding]; other site 290340006706 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 290340006707 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 290340006708 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290340006709 homodimer interface [polypeptide binding]; other site 290340006710 oligonucleotide binding site [chemical binding]; other site 290340006711 Vitamin K epoxide reductase family; Region: VKOR; cl01729 290340006712 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290340006713 active site 290340006714 multimer interface [polypeptide binding]; other site 290340006715 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 290340006716 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 290340006717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340006718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340006719 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 290340006720 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290340006721 HIGH motif; other site 290340006722 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290340006723 active site 290340006724 KMSKS motif; other site 290340006725 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 290340006726 tRNA binding surface [nucleotide binding]; other site 290340006727 anticodon binding site; other site 290340006728 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340006729 putative catalytic site [active] 290340006730 putative metal binding site [ion binding]; other site 290340006731 putative phosphate binding site [ion binding]; other site 290340006732 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340006733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006734 NAD(P) binding site [chemical binding]; other site 290340006735 active site 290340006736 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 290340006737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006738 active site 290340006739 HIGH motif; other site 290340006740 nucleotide binding site [chemical binding]; other site 290340006741 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006742 active site 290340006743 KMSKS motif; other site 290340006744 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290340006745 tRNA binding surface [nucleotide binding]; other site 290340006746 anticodon binding site; other site 290340006747 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340006748 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 290340006749 putative DNA binding site [nucleotide binding]; other site 290340006750 catalytic residue [active] 290340006751 putative H2TH interface [polypeptide binding]; other site 290340006752 putative catalytic residues [active] 290340006753 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340006754 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290340006755 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340006756 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340006757 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290340006758 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 290340006759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006761 Walker A motif; other site 290340006762 ATP binding site [chemical binding]; other site 290340006763 Walker B motif; other site 290340006764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290340006765 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 290340006766 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290340006767 oligomer interface [polypeptide binding]; other site 290340006768 active site residues [active] 290340006769 Clp protease; Region: CLP_protease; pfam00574 290340006770 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290340006771 oligomer interface [polypeptide binding]; other site 290340006772 active site residues [active] 290340006773 trigger factor; Provisional; Region: tig; PRK01490 290340006774 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 290340006775 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290340006776 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340006777 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 290340006778 putative DNA binding site [nucleotide binding]; other site 290340006779 catalytic residue [active] 290340006780 putative H2TH interface [polypeptide binding]; other site 290340006781 putative catalytic residues [active] 290340006782 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340006783 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 290340006784 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290340006785 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290340006786 Zn binding site [ion binding]; other site 290340006787 OsmC-like protein; Region: OsmC; cl00767 290340006788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006789 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290340006790 NAD(P) binding site [chemical binding]; other site 290340006791 active site 290340006792 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290340006793 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 290340006794 apolar tunnel; other site 290340006795 heme binding site [chemical binding]; other site 290340006796 dimerization interface [polypeptide binding]; other site 290340006797 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 290340006798 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290340006799 active site 290340006800 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290340006801 catalytic triad [active] 290340006802 dimer interface [polypeptide binding]; other site 290340006803 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 290340006804 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340006805 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340006806 ABC transporter; Region: ABC_tran_2; pfam12848 290340006807 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340006808 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340006809 dimer interface [polypeptide binding]; other site 290340006810 ssDNA binding site [nucleotide binding]; other site 290340006811 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340006812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340006813 Coenzyme A binding pocket [chemical binding]; other site 290340006814 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340006815 active site 290340006816 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290340006817 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 290340006818 active site 290340006819 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 290340006820 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 290340006821 catalytic site [active] 290340006822 putative active site [active] 290340006823 putative substrate binding site [chemical binding]; other site 290340006824 dimer interface [polypeptide binding]; other site 290340006825 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340006826 active site 290340006827 catalytic residues [active] 290340006828 metal binding site [ion binding]; metal-binding site 290340006829 Protein of unknown function DUF262; Region: DUF262; cl14890 290340006830 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 290340006831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006832 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290340006833 Protein of unknown function (DUF328); Region: DUF328; cl01143 290340006834 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 290340006835 Putative zinc ribbon domain; Region: DUF164; pfam02591 290340006836 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 290340006837 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 290340006838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340006839 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340006840 dimer interface [polypeptide binding]; other site 290340006841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340006842 catalytic residue [active] 290340006843 serine O-acetyltransferase; Region: cysE; TIGR01172 290340006844 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290340006845 trimer interface [polypeptide binding]; other site 290340006846 active site 290340006847 substrate binding site [chemical binding]; other site 290340006848 CoA binding site [chemical binding]; other site 290340006849 short chain dehydrogenase; Validated; Region: PRK06182 290340006850 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290340006851 NADP binding site [chemical binding]; other site 290340006852 active site 290340006853 steroid binding site; other site 290340006854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006855 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 290340006856 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 290340006857 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340006858 Helix-turn-helix domains; Region: HTH; cl00088 290340006859 DNA-binding site [nucleotide binding]; DNA binding site 290340006860 FCD domain; Region: FCD; cl11656 290340006861 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 290340006862 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 290340006863 putative NAD(P) binding site [chemical binding]; other site 290340006864 catalytic Zn binding site [ion binding]; other site 290340006865 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290340006866 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340006867 NADP binding site [chemical binding]; other site 290340006868 homodimer interface [polypeptide binding]; other site 290340006869 active site 290340006870 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290340006871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006872 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340006873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006874 OpgC protein; Region: OpgC_C; cl00792 290340006875 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006877 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340006878 putative substrate translocation pore; other site 290340006879 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340006880 Helix-turn-helix domains; Region: HTH; cl00088 290340006881 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340006882 NAD-dependent deacetylase; Provisional; Region: PRK05333 290340006883 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290340006884 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 290340006885 dimer interface [polypeptide binding]; other site 290340006886 catalytic triad [active] 290340006887 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 290340006888 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290340006889 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290340006890 dimer interface [polypeptide binding]; other site 290340006891 TPP-binding site [chemical binding]; other site 290340006892 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340006893 Helix-turn-helix domains; Region: HTH; cl00088 290340006894 Acyl transferase domain; Region: Acyl_transf_1; cl08282 290340006895 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290340006896 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290340006897 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290340006898 dimer interface [polypeptide binding]; other site 290340006899 active site 290340006900 CoA binding pocket [chemical binding]; other site 290340006901 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290340006902 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290340006903 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290340006904 dimer interface [polypeptide binding]; other site 290340006905 active site 290340006906 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 290340006907 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340006908 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340006909 active site 290340006910 DNA binding site [nucleotide binding] 290340006911 Int/Topo IB signature motif; other site 290340006912 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290340006913 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290340006914 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 290340006915 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 290340006916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006917 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290340006918 Restriction endonuclease; Region: Mrr_cat; cl00516 290340006919 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 290340006920 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290340006921 RNA/DNA hybrid binding site [nucleotide binding]; other site 290340006922 active site 290340006923 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 290340006924 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 290340006925 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290340006926 RimM N-terminal domain; Region: RimM; pfam01782 290340006927 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 290340006928 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 290340006929 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 290340006930 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 290340006931 putative metal binding site [ion binding]; other site 290340006932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340006933 active site 290340006934 metal binding site [ion binding]; metal-binding site 290340006935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340006936 Amidohydrolase; Region: Amidohydro_4; pfam13147 290340006937 active site 290340006938 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290340006939 ThiC-associated domain; Region: ThiC-associated; pfam13667 290340006940 ThiC family; Region: ThiC; cl08031 290340006941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340006942 signal recognition particle protein; Provisional; Region: PRK10867 290340006943 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 290340006944 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290340006945 P loop; other site 290340006946 GTP binding site [chemical binding]; other site 290340006947 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290340006948 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 290340006949 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290340006950 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290340006951 Nitrogen regulatory protein P-II; Region: P-II; cl00412 290340006952 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290340006953 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290340006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340006956 putative substrate translocation pore; other site 290340006957 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290340006958 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 290340006959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340006960 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290340006961 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 290340006962 Walker A/P-loop; other site 290340006963 ATP binding site [chemical binding]; other site 290340006964 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290340006965 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 290340006966 ABC transporter signature motif; other site 290340006967 Walker B; other site 290340006968 D-loop; other site 290340006969 H-loop/switch region; other site 290340006970 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340006971 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340006972 Bacterial Ig-like domain; Region: Big_5; cl01012 290340006973 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340006974 Bacterial Ig-like domain; Region: Big_5; cl01012 290340006975 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340006976 Bacterial Ig-like domain; Region: Big_5; cl01012 290340006977 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340006978 translocation protein TolB; Provisional; Region: tolB; PRK03629 290340006979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340006981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006982 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 290340006983 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 290340006984 DNA binding site [nucleotide binding] 290340006985 catalytic residue [active] 290340006986 H2TH interface [polypeptide binding]; other site 290340006987 putative catalytic residues [active] 290340006988 turnover-facilitating residue; other site 290340006989 intercalation triad [nucleotide binding]; other site 290340006990 8OG recognition residue [nucleotide binding]; other site 290340006991 putative reading head residues; other site 290340006992 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340006993 ribonuclease III; Reviewed; Region: rnc; PRK00102 290340006994 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 290340006995 dimerization interface [polypeptide binding]; other site 290340006996 active site 290340006997 metal binding site [ion binding]; metal-binding site 290340006998 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 290340006999 dsRNA binding site [nucleotide binding]; other site 290340007000 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 290340007001 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 290340007002 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290340007003 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290340007004 active site 290340007005 (T/H)XGH motif; other site 290340007006 aminotransferase; Validated; Region: PRK07777 290340007007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340007008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007009 homodimer interface [polypeptide binding]; other site 290340007010 catalytic residue [active] 290340007011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340007012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340007013 S-adenosylmethionine binding site [chemical binding]; other site 290340007014 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290340007015 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290340007016 generic binding surface II; other site 290340007017 ssDNA binding site; other site 290340007018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007019 ATP binding site [chemical binding]; other site 290340007020 putative Mg++ binding site [ion binding]; other site 290340007021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007022 nucleotide binding region [chemical binding]; other site 290340007023 ATP-binding site [chemical binding]; other site 290340007024 DAK2 domain; Region: Dak2; cl03685 290340007025 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 290340007026 thiamine monophosphate kinase; Provisional; Region: PRK05731 290340007027 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290340007028 ATP binding site [chemical binding]; other site 290340007029 dimerization interface [polypeptide binding]; other site 290340007030 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 290340007031 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290340007032 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290340007033 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340007034 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290340007035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007036 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290340007037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340007038 putative acyl-acceptor binding pocket; other site 290340007039 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290340007040 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290340007041 hinge; other site 290340007042 active site 290340007043 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290340007044 substrate binding site [chemical binding]; other site 290340007045 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290340007046 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290340007047 substrate binding site [chemical binding]; other site 290340007048 ligand binding site [chemical binding]; other site 290340007049 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340007050 Helix-turn-helix domains; Region: HTH; cl00088 290340007051 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340007052 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 290340007053 YfjP GTPase; Region: YfjP; cd11383 290340007054 G1 box; other site 290340007055 GTP/Mg2+ binding site [chemical binding]; other site 290340007056 Switch I region; other site 290340007057 G2 box; other site 290340007058 Switch II region; other site 290340007059 G3 box; other site 290340007060 G4 box; other site 290340007061 G5 box; other site 290340007062 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290340007063 G1 box; other site 290340007064 GTP/Mg2+ binding site [chemical binding]; other site 290340007065 G2 box; other site 290340007066 Switch I region; other site 290340007067 G3 box; other site 290340007068 Switch II region; other site 290340007069 G5 box; other site 290340007070 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 290340007071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340007072 motif II; other site 290340007073 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290340007074 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290340007075 HIGH motif; other site 290340007076 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290340007077 active site 290340007078 KMSKS motif; other site 290340007079 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340007080 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 290340007081 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340007082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340007083 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 290340007084 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290340007085 homodimer interface [polypeptide binding]; other site 290340007086 substrate-cofactor binding pocket; other site 290340007087 catalytic residue [active] 290340007088 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 290340007089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340007090 Histidine kinase; Region: HisKA_3; pfam07730 290340007091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340007092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340007093 active site 290340007094 phosphorylation site [posttranslational modification] 290340007095 intermolecular recognition site; other site 290340007096 dimerization interface [polypeptide binding]; other site 290340007097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340007098 DNA binding residues [nucleotide binding] 290340007099 dimerization interface [polypeptide binding]; other site 290340007100 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340007101 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290340007102 Walker A/P-loop; other site 290340007103 ATP binding site [chemical binding]; other site 290340007104 Q-loop/lid; other site 290340007105 ABC transporter signature motif; other site 290340007106 Walker B; other site 290340007107 D-loop; other site 290340007108 H-loop/switch region; other site 290340007109 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340007110 FtsX-like permease family; Region: FtsX; cl15850 290340007111 FtsX-like permease family; Region: FtsX; cl15850 290340007112 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 290340007113 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290340007114 active site 290340007115 HIGH motif; other site 290340007116 KMSKS motif; other site 290340007117 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290340007118 tRNA binding surface [nucleotide binding]; other site 290340007119 anticodon binding site; other site 290340007120 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290340007121 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340007122 Walker A/P-loop; other site 290340007123 ATP binding site [chemical binding]; other site 290340007124 Q-loop/lid; other site 290340007125 ABC transporter signature motif; other site 290340007126 Walker B; other site 290340007127 D-loop; other site 290340007128 H-loop/switch region; other site 290340007129 FtsX-like permease family; Region: FtsX; cl15850 290340007130 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 290340007131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007132 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 290340007133 putative L-serine binding site [chemical binding]; other site 290340007134 ketol-acid reductoisomerase; Provisional; Region: PRK05479 290340007135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007136 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290340007137 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290340007138 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290340007139 putative valine binding site [chemical binding]; other site 290340007140 dimer interface [polypeptide binding]; other site 290340007141 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290340007142 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 290340007143 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340007144 PYR/PP interface [polypeptide binding]; other site 290340007145 dimer interface [polypeptide binding]; other site 290340007146 TPP binding site [chemical binding]; other site 290340007147 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340007148 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290340007149 TPP-binding site [chemical binding]; other site 290340007150 dimer interface [polypeptide binding]; other site 290340007151 Dehydratase family; Region: ILVD_EDD; cl00340 290340007152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340007153 Helix-turn-helix domains; Region: HTH; cl00088 290340007154 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340007155 putative dimerization interface [polypeptide binding]; other site 290340007156 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290340007157 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290340007158 Helix-turn-helix domains; Region: HTH; cl00088 290340007159 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290340007160 catalytic triad [active] 290340007161 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 290340007162 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290340007163 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340007164 peptide binding site [polypeptide binding]; other site 290340007165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007166 Predicted dehydrogenase [General function prediction only]; Region: COG0579 290340007167 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290340007168 Protein export membrane protein; Region: SecD_SecF; cl14618 290340007169 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290340007170 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340007171 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 290340007172 Helix-turn-helix domains; Region: HTH; cl00088 290340007173 Helix-turn-helix domains; Region: HTH; cl00088 290340007174 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290340007175 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 290340007176 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 290340007177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 290340007178 transmembrane helices; other site 290340007179 Electron transfer DM13; Region: DM13; cl02735 290340007180 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340007181 GtrA-like protein; Region: GtrA; cl00971 290340007182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340007183 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 290340007184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007185 catalytic residue [active] 290340007186 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 290340007187 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290340007188 dimerization interface [polypeptide binding]; other site 290340007189 active site 290340007190 L-aspartate oxidase; Provisional; Region: PRK07804 290340007191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007192 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340007193 Quinolinate synthetase A protein; Region: NadA; cl00420 290340007194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340007195 nudix motif; other site 290340007196 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340007197 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340007198 Helix-turn-helix domains; Region: HTH; cl00088 290340007199 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 290340007200 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340007201 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340007202 tetramer interface [polypeptide binding]; other site 290340007203 TPP-binding site [chemical binding]; other site 290340007204 heterodimer interface [polypeptide binding]; other site 290340007205 phosphorylation loop region [posttranslational modification] 290340007206 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340007207 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340007208 alpha subunit interface [polypeptide binding]; other site 290340007209 TPP binding site [chemical binding]; other site 290340007210 heterodimer interface [polypeptide binding]; other site 290340007211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340007212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340007213 E3 interaction surface; other site 290340007214 lipoyl attachment site [posttranslational modification]; other site 290340007215 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 290340007216 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340007217 nucleophilic elbow; other site 290340007218 catalytic triad; other site 290340007219 Retinoic acid induced 16-like protein; Region: RAI16-like; pfam10257 290340007220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340007221 active site 290340007222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007223 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340007224 putative substrate translocation pore; other site 290340007225 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340007226 Helix-turn-helix domains; Region: HTH; cl00088 290340007227 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340007228 Spore germination protein; Region: Spore_permease; cl15802 290340007229 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290340007230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340007231 Sulfatase; Region: Sulfatase; cl10460 290340007232 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290340007233 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340007234 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290340007235 Walker A/P-loop; other site 290340007236 ATP binding site [chemical binding]; other site 290340007237 Q-loop/lid; other site 290340007238 ABC transporter signature motif; other site 290340007239 Walker B; other site 290340007240 D-loop; other site 290340007241 H-loop/switch region; other site 290340007242 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340007243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340007244 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340007245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340007246 NMT1/THI5 like; Region: NMT1; pfam09084 290340007247 NMT1-like family; Region: NMT1_2; cl15260 290340007248 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340007249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340007250 active site 290340007251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340007252 Helix-turn-helix domains; Region: HTH; cl00088 290340007253 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 290340007254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007255 Walker A/P-loop; other site 290340007256 ATP binding site [chemical binding]; other site 290340007257 Q-loop/lid; other site 290340007258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007259 ABC transporter signature motif; other site 290340007260 Walker B; other site 290340007261 D-loop; other site 290340007262 H-loop/switch region; other site 290340007263 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290340007264 active site 290340007265 metal binding site [ion binding]; metal-binding site 290340007266 DNA binding site [nucleotide binding] 290340007267 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290340007268 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290340007269 amphipathic channel; other site 290340007270 Asn-Pro-Ala signature motifs; other site 290340007271 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340007272 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340007273 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 290340007274 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 290340007275 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 290340007276 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 290340007277 active site 290340007278 catalytic site [active] 290340007279 substrate binding site [chemical binding]; other site 290340007280 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 290340007281 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340007282 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 290340007283 Walker A/P-loop; other site 290340007284 ATP binding site [chemical binding]; other site 290340007285 Q-loop/lid; other site 290340007286 ABC transporter signature motif; other site 290340007287 Walker B; other site 290340007288 D-loop; other site 290340007289 H-loop/switch region; other site 290340007290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340007291 DNA-binding site [nucleotide binding]; DNA binding site 290340007292 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340007293 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290340007294 dimerization interface [polypeptide binding]; other site 290340007295 active site 290340007296 ribonuclease PH; Reviewed; Region: rph; PRK00173 290340007297 Ribonuclease PH; Region: RNase_PH_bact; cd11362 290340007298 hexamer interface [polypeptide binding]; other site 290340007299 active site 290340007300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340007301 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290340007302 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 290340007303 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 290340007304 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 290340007305 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 290340007306 active site 290340007307 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 290340007308 Isochorismatase family; Region: Isochorismatase; pfam00857 290340007309 catalytic triad [active] 290340007310 conserved cis-peptide bond; other site 290340007311 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290340007312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007313 ATP binding site [chemical binding]; other site 290340007314 putative Mg++ binding site [ion binding]; other site 290340007315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007316 ATP-binding site [chemical binding]; other site 290340007317 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 290340007318 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290340007319 active site 290340007320 trimer interface [polypeptide binding]; other site 290340007321 allosteric site; other site 290340007322 active site lid [active] 290340007323 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290340007324 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290340007325 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 290340007326 Walker A/P-loop; other site 290340007327 ATP binding site [chemical binding]; other site 290340007328 Q-loop/lid; other site 290340007329 ABC transporter signature motif; other site 290340007330 Walker B; other site 290340007331 D-loop; other site 290340007332 H-loop/switch region; other site 290340007333 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 290340007334 active site 290340007335 FMN binding site [chemical binding]; other site 290340007336 substrate binding site [chemical binding]; other site 290340007337 homotetramer interface [polypeptide binding]; other site 290340007338 catalytic residue [active] 290340007339 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290340007340 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340007341 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290340007342 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 290340007343 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 290340007344 Protein of unknown function DUF91; Region: DUF91; cl00709 290340007345 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290340007346 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340007347 active site 290340007348 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290340007349 DNA-binding site [nucleotide binding]; DNA binding site 290340007350 RNA-binding motif; other site 290340007351 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 290340007352 Putative esterase; Region: Esterase; pfam00756 290340007353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340007354 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 290340007355 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290340007356 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 290340007357 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290340007358 alpha subunit interaction interface [polypeptide binding]; other site 290340007359 Walker A motif; other site 290340007360 ATP binding site [chemical binding]; other site 290340007361 Walker B motif; other site 290340007362 inhibitor binding site; inhibition site 290340007363 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290340007364 ATP synthase; Region: ATP-synt; cl00365 290340007365 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 290340007366 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290340007367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 290340007368 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290340007369 beta subunit interaction interface [polypeptide binding]; other site 290340007370 Walker A motif; other site 290340007371 ATP binding site [chemical binding]; other site 290340007372 Walker B motif; other site 290340007373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290340007374 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290340007375 Plant ATP synthase F0; Region: YMF19; cl07975 290340007376 ATP synthase subunit C; Region: ATP-synt_C; cl00466 290340007377 ATP synthase A chain; Region: ATP-synt_A; cl00413 290340007378 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 290340007379 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290340007380 Mg++ binding site [ion binding]; other site 290340007381 putative catalytic motif [active] 290340007382 substrate binding site [chemical binding]; other site 290340007383 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290340007384 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007385 active site 290340007386 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 290340007387 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290340007388 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290340007389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340007390 S-adenosylmethionine binding site [chemical binding]; other site 290340007391 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290340007392 RF-1 domain; Region: RF-1; cl02875 290340007393 RF-1 domain; Region: RF-1; cl02875 290340007394 transcription termination factor Rho; Provisional; Region: PRK12678 290340007395 transcription termination factor Rho; Provisional; Region: PRK12608 290340007396 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290340007397 RNA binding site [nucleotide binding]; other site 290340007398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007399 Walker A motif; other site 290340007400 ATP binding site [chemical binding]; other site 290340007401 Walker B motif; other site 290340007402 homoserine kinase; Provisional; Region: PRK01212 290340007403 threonine synthase; Reviewed; Region: PRK06721 290340007404 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 290340007405 homodimer interface [polypeptide binding]; other site 290340007406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007407 catalytic residue [active] 290340007408 homoserine dehydrogenase; Provisional; Region: PRK06349 290340007409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007410 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290340007411 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 290340007412 diaminopimelate decarboxylase; Region: lysA; TIGR01048 290340007413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290340007414 active site 290340007415 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340007416 substrate binding site [chemical binding]; other site 290340007417 catalytic residues [active] 290340007418 dimer interface [polypeptide binding]; other site 290340007419 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 290340007420 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 290340007421 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290340007422 active site 290340007423 HIGH motif; other site 290340007424 KMSK motif region; other site 290340007425 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290340007426 tRNA binding surface [nucleotide binding]; other site 290340007427 anticodon binding site; other site 290340007428 FMN-binding domain; Region: FMN_bind; cl01081 290340007429 ApbE family; Region: ApbE; cl00643 290340007430 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 290340007431 FAD binding pocket [chemical binding]; other site 290340007432 conserved FAD binding motif [chemical binding]; other site 290340007433 phosphate binding motif [ion binding]; other site 290340007434 beta-alpha-beta structure motif; other site 290340007435 NAD binding pocket [chemical binding]; other site 290340007436 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 290340007437 active site 290340007438 Zn binding site [ion binding]; other site 290340007439 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 290340007440 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290340007441 conserved cys residue [active] 290340007442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340007443 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 290340007444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007445 ATP binding site [chemical binding]; other site 290340007446 putative Mg++ binding site [ion binding]; other site 290340007447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007448 nucleotide binding region [chemical binding]; other site 290340007449 ATP-binding site [chemical binding]; other site 290340007450 Helicase associated domain (HA2); Region: HA2; cl04503 290340007451 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 290340007452 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 290340007453 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 290340007454 nucleotide binding site/active site [active] 290340007455 HIT family signature motif; other site 290340007456 catalytic residue [active] 290340007457 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340007458 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290340007459 putative NAD(P) binding site [chemical binding]; other site 290340007460 putative substrate binding site [chemical binding]; other site 290340007461 catalytic Zn binding site [ion binding]; other site 290340007462 structural Zn binding site [ion binding]; other site 290340007463 dimer interface [polypeptide binding]; other site 290340007464 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290340007465 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340007466 active site residue [active] 290340007467 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340007468 active site residue [active] 290340007469 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340007470 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290340007471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007472 catalytic residue [active] 290340007473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340007474 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290340007475 metal binding site 2 [ion binding]; metal-binding site 290340007476 putative DNA binding helix; other site 290340007477 metal binding site 1 [ion binding]; metal-binding site 290340007478 dimer interface [polypeptide binding]; other site 290340007479 structural Zn2+ binding site [ion binding]; other site 290340007480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340007481 putative PBP binding regions; other site 290340007482 ABC-ATPase subunit interface; other site 290340007483 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340007484 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 290340007485 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340007486 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290340007487 intersubunit interface [polypeptide binding]; other site 290340007488 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340007489 FOG: CBS domain [General function prediction only]; Region: COG0517 290340007490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340007491 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340007492 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340007493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340007494 Transporter associated domain; Region: CorC_HlyC; cl08393 290340007495 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 290340007496 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 290340007497 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290340007498 TPP-binding site [chemical binding]; other site 290340007499 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 290340007500 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 290340007501 active site 290340007502 catalytic triad [active] 290340007503 oxyanion hole [active] 290340007504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340007505 Uncharacterized conserved protein [Function unknown]; Region: COG3595 290340007506 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340007507 Helix-turn-helix domains; Region: HTH; cl00088 290340007508 Putative zinc-finger; Region: zf-HC2; cl15806 290340007509 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 290340007510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340007511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340007512 DNA binding residues [nucleotide binding] 290340007513 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290340007514 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 290340007515 hinge; other site 290340007516 active site 290340007517 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290340007518 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290340007519 GTP/Mg2+ binding site [chemical binding]; other site 290340007520 G4 box; other site 290340007521 G5 box; other site 290340007522 G1 box; other site 290340007523 Switch I region; other site 290340007524 G2 box; other site 290340007525 G3 box; other site 290340007526 Switch II region; other site 290340007527 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 290340007528 active site 290340007529 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290340007530 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340007531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007532 catalytic residue [active] 290340007533 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290340007534 Helix-turn-helix domains; Region: HTH; cl00088 290340007535 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340007536 FeoA domain; Region: FeoA; cl00838 290340007537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340007539 putative substrate translocation pore; other site 290340007540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007541 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340007542 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290340007543 protein binding site [polypeptide binding]; other site 290340007544 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290340007545 SmpB-tmRNA interface; other site 290340007546 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340007547 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 290340007548 FtsX-like permease family; Region: FtsX; cl15850 290340007549 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 290340007550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007551 Walker A/P-loop; other site 290340007552 ATP binding site [chemical binding]; other site 290340007553 Q-loop/lid; other site 290340007554 ABC transporter signature motif; other site 290340007555 Walker B; other site 290340007556 D-loop; other site 290340007557 H-loop/switch region; other site 290340007558 peptide chain release factor 2; Validated; Region: prfB; PRK00578 290340007559 RF-1 domain; Region: RF-1; cl02875 290340007560 RF-1 domain; Region: RF-1; cl02875 290340007561 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 290340007562 TadE-like protein; Region: TadE; cl10688 290340007563 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 290340007564 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 290340007565 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 290340007566 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340007567 ATP binding site [chemical binding]; other site 290340007568 Walker A motif; other site 290340007569 hexamer interface [polypeptide binding]; other site 290340007570 Walker B motif; other site 290340007571 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 290340007572 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 290340007573 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 290340007574 active site 290340007575 Family description; Region: VCBS; pfam13517 290340007576 Family description; Region: VCBS; pfam13517 290340007577 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 290340007578 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290340007579 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340007580 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340007581 Family description; Region: VCBS; pfam13517 290340007582 Family description; Region: VCBS; pfam13517 290340007583 FG-GAP repeat; Region: FG-GAP; cl15299 290340007584 Family description; Region: VCBS; pfam13517 290340007585 FG-GAP repeat; Region: FG-GAP; cl15299 290340007586 Family description; Region: VCBS; pfam13517 290340007587 FG-GAP repeat; Region: FG-GAP; cl15299 290340007588 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290340007589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007590 active site 290340007591 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 290340007592 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 290340007593 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 290340007594 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 290340007595 Walker A/P-loop; other site 290340007596 ATP binding site [chemical binding]; other site 290340007597 Q-loop/lid; other site 290340007598 ABC transporter signature motif; other site 290340007599 Walker B; other site 290340007600 D-loop; other site 290340007601 H-loop/switch region; other site 290340007602 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340007603 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340007604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007605 active site 290340007606 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 290340007607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007608 UDP-galactopyranose mutase; Region: GLF; pfam03275 290340007609 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340007610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007611 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340007612 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 290340007613 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290340007614 inhibitor-cofactor binding pocket; inhibition site 290340007615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007616 catalytic residue [active] 290340007617 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290340007618 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340007619 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 290340007620 putative trimer interface [polypeptide binding]; other site 290340007621 putative active site [active] 290340007622 putative substrate binding site [chemical binding]; other site 290340007623 putative CoA binding site [chemical binding]; other site 290340007624 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340007625 phosphopeptide binding site; other site 290340007626 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 290340007627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007629 Transcription factor WhiB; Region: Whib; pfam02467 290340007630 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 290340007631 PAS fold; Region: PAS_4; pfam08448 290340007632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340007633 Histidine kinase; Region: HisKA_2; cl06527 290340007634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340007635 ATP binding site [chemical binding]; other site 290340007636 Mg2+ binding site [ion binding]; other site 290340007637 G-X-G motif; other site 290340007638 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 290340007639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007640 SAF domain; Region: SAF; cl00555 290340007641 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340007642 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340007643 putative peptidoglycan binding site; other site 290340007644 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 290340007645 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 290340007646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007647 nucleotide binding region [chemical binding]; other site 290340007648 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 290340007649 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 290340007650 30S subunit binding site; other site 290340007651 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 290340007652 lipoprotein LpqB; Provisional; Region: PRK13614 290340007653 Sporulation and spore germination; Region: Germane; cl11253 290340007654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340007655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290340007656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340007657 dimer interface [polypeptide binding]; other site 290340007658 phosphorylation site [posttranslational modification] 290340007659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340007660 ATP binding site [chemical binding]; other site 290340007661 G-X-G motif; other site 290340007662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340007663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340007664 active site 290340007665 phosphorylation site [posttranslational modification] 290340007666 intermolecular recognition site; other site 290340007667 dimerization interface [polypeptide binding]; other site 290340007668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340007669 DNA binding site [nucleotide binding] 290340007670 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 290340007671 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 290340007672 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 290340007673 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340007674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340007675 Walker A motif; other site 290340007676 ATP binding site [chemical binding]; other site 290340007677 Walker B motif; other site 290340007678 arginine finger; other site 290340007679 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 290340007680 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340007681 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340007682 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 290340007683 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 290340007684 Chorismate mutase type II; Region: CM_2; cl00693 290340007685 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340007686 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340007687 Walker A/P-loop; other site 290340007688 ATP binding site [chemical binding]; other site 290340007689 Q-loop/lid; other site 290340007690 ABC transporter signature motif; other site 290340007691 Walker B; other site 290340007692 D-loop; other site 290340007693 H-loop/switch region; other site 290340007694 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340007695 Walker A/P-loop; other site 290340007696 ATP binding site [chemical binding]; other site 290340007697 Q-loop/lid; other site 290340007698 ABC transporter signature motif; other site 290340007699 Walker B; other site 290340007700 D-loop; other site 290340007701 H-loop/switch region; other site 290340007702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340007703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340007704 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290340007705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007706 dimer interface [polypeptide binding]; other site 290340007707 conserved gate region; other site 290340007708 ABC-ATPase subunit interface; other site 290340007709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340007710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007711 dimer interface [polypeptide binding]; other site 290340007712 conserved gate region; other site 290340007713 putative PBP binding loops; other site 290340007714 ABC-ATPase subunit interface; other site 290340007715 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 290340007716 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340007717 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 290340007718 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290340007719 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290340007720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340007721 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340007722 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 290340007723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007724 catalytic residue [active] 290340007725 Predicted transcriptional regulator [Transcription]; Region: COG2345 290340007726 Helix-turn-helix domains; Region: HTH; cl00088 290340007727 diacylglycerol kinase; Reviewed; Region: PRK11914 290340007728 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340007729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340007730 HSP70 interaction site [polypeptide binding]; other site 290340007731 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290340007732 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 290340007733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340007734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340007735 DNA binding residues [nucleotide binding] 290340007736 putative anti-sigmaE protein; Provisional; Region: PRK13920 290340007737 Anti-sigma-K factor rskA; Region: RskA; pfam10099 290340007738 GntP family permease; Region: GntP_permease; pfam02447 290340007739 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 290340007740 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290340007741 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 290340007742 ATP-binding site [chemical binding]; other site 290340007743 Gluconate-6-phosphate binding site [chemical binding]; other site 290340007744 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340007745 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290340007746 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 290340007747 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290340007748 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290340007749 Ligand Binding Site [chemical binding]; other site 290340007750 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340007751 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290340007752 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290340007753 PspA/IM30 family; Region: PspA_IM30; pfam04012 290340007754 UTRA domain; Region: UTRA; cl01230 290340007755 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340007756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340007757 DNA-binding site [nucleotide binding]; DNA binding site 290340007758 UTRA domain; Region: UTRA; cl01230 290340007759 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 290340007760 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 290340007761 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 290340007762 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290340007763 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 290340007764 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 290340007765 Protein of unknown function DUF45; Region: DUF45; cl00636 290340007766 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340007767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007768 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340007769 Family description; Region: UvrD_C_2; cl15862 290340007770 HRDC domain; Region: HRDC; cl02578 290340007771 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 290340007772 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 290340007773 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 290340007774 putative NADH binding site [chemical binding]; other site 290340007775 putative active site [active] 290340007776 nudix motif; other site 290340007777 putative metal binding site [ion binding]; other site 290340007778 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340007779 active site 290340007780 ATP binding site [chemical binding]; other site 290340007781 substrate binding site [chemical binding]; other site 290340007782 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340007783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340007784 Family description; Region: UvrD_C_2; cl15862 290340007785 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290340007786 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340007787 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340007788 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290340007789 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340007790 DNA binding site [nucleotide binding] 290340007791 active site 290340007792 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290340007793 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 290340007794 active site 290340007795 catalytic site [active] 290340007796 substrate binding site [chemical binding]; other site 290340007797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340007798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340007799 substrate binding pocket [chemical binding]; other site 290340007800 membrane-bound complex binding site; other site 290340007801 hinge residues; other site 290340007802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007803 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340007804 dimer interface [polypeptide binding]; other site 290340007805 conserved gate region; other site 290340007806 putative PBP binding loops; other site 290340007807 ABC-ATPase subunit interface; other site 290340007808 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340007809 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340007810 Walker A/P-loop; other site 290340007811 ATP binding site [chemical binding]; other site 290340007812 Q-loop/lid; other site 290340007813 ABC transporter signature motif; other site 290340007814 Walker B; other site 290340007815 D-loop; other site 290340007816 H-loop/switch region; other site 290340007817 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340007818 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290340007819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340007820 inhibitor-cofactor binding pocket; inhibition site 290340007821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007822 catalytic residue [active] 290340007823 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290340007824 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340007825 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 290340007826 dimer interface [polypeptide binding]; other site 290340007827 active site 290340007828 Schiff base residues; other site 290340007829 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290340007830 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 290340007831 domain interfaces; other site 290340007832 active site 290340007833 ferrochelatase; Reviewed; Region: hemH; PRK00035 290340007834 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290340007835 C-terminal domain interface [polypeptide binding]; other site 290340007836 active site 290340007837 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290340007838 active site 290340007839 N-terminal domain interface [polypeptide binding]; other site 290340007840 Chlorite dismutase; Region: Chlor_dismutase; cl01280 290340007841 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 290340007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007843 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290340007844 substrate binding site [chemical binding]; other site 290340007845 active site 290340007846 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290340007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007848 NAD(P) binding pocket [chemical binding]; other site 290340007849 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290340007850 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 290340007851 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290340007852 ATP binding site [chemical binding]; other site 290340007853 substrate interface [chemical binding]; other site 290340007854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340007855 active site residue [active] 290340007856 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 290340007857 Helix-turn-helix domains; Region: HTH; cl00088 290340007858 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 290340007859 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 290340007860 aromatic arch; other site 290340007861 DCoH dimer interaction site [polypeptide binding]; other site 290340007862 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 290340007863 DCoH tetramer interaction site [polypeptide binding]; other site 290340007864 substrate binding site [chemical binding]; other site 290340007865 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290340007866 ThiS interaction site; other site 290340007867 putative active site [active] 290340007868 tetramer interface [polypeptide binding]; other site 290340007869 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290340007870 thiS-thiF/thiG interaction site; other site 290340007871 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 290340007872 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290340007873 thiamine phosphate binding site [chemical binding]; other site 290340007874 active site 290340007875 pyrophosphate binding site [ion binding]; other site 290340007876 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 290340007877 TM2 domain; Region: TM2; cl00984 290340007878 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 290340007879 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 290340007880 RNB domain; Region: RNB; pfam00773 290340007881 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290340007882 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340007883 ATP binding site [chemical binding]; other site 290340007884 Mg++ binding site [ion binding]; other site 290340007885 motif III; other site 290340007886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007887 nucleotide binding region [chemical binding]; other site 290340007888 ATP-binding site [chemical binding]; other site 290340007889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007890 MarC family integral membrane protein; Region: MarC; cl00919 290340007891 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290340007892 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 290340007893 proline aminopeptidase P II; Provisional; Region: PRK10879 290340007894 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290340007895 active site 290340007896 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 290340007897 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 290340007898 MgtE intracellular N domain; Region: MgtE_N; cl15244 290340007899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290340007900 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 290340007901 Domain of unknown function DUF59; Region: DUF59; cl00941 290340007902 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 290340007903 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290340007904 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290340007905 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 290340007906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340007907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340007908 DNA binding residues [nucleotide binding] 290340007909 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340007910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007911 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 290340007912 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340007913 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290340007914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340007915 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340007916 Walker A/P-loop; other site 290340007917 ATP binding site [chemical binding]; other site 290340007918 Q-loop/lid; other site 290340007919 ABC transporter signature motif; other site 290340007920 Walker B; other site 290340007921 D-loop; other site 290340007922 H-loop/switch region; other site 290340007923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340007924 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340007925 substrate binding pocket [chemical binding]; other site 290340007926 membrane-bound complex binding site; other site 290340007927 hinge residues; other site 290340007928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340007929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007930 dimer interface [polypeptide binding]; other site 290340007931 conserved gate region; other site 290340007932 putative PBP binding loops; other site 290340007933 ABC-ATPase subunit interface; other site 290340007934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007935 dimer interface [polypeptide binding]; other site 290340007936 conserved gate region; other site 290340007937 putative PBP binding loops; other site 290340007938 ABC-ATPase subunit interface; other site 290340007939 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 290340007940 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 290340007941 metal binding site [ion binding]; metal-binding site 290340007942 putative dimer interface [polypeptide binding]; other site 290340007943 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 290340007944 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 290340007945 putative trimer interface [polypeptide binding]; other site 290340007946 putative CoA binding site [chemical binding]; other site 290340007947 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290340007948 UDP-glucose 4-epimerase; Region: PLN02240 290340007949 NAD binding site [chemical binding]; other site 290340007950 homodimer interface [polypeptide binding]; other site 290340007951 active site 290340007952 substrate binding site [chemical binding]; other site 290340007953 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 290340007954 dimer interface [polypeptide binding]; other site 290340007955 Citrate synthase; Region: Citrate_synt; pfam00285 290340007956 active site 290340007957 citrylCoA binding site [chemical binding]; other site 290340007958 NADH binding [chemical binding]; other site 290340007959 cationic pore residues; other site 290340007960 oxalacetate/citrate binding site [chemical binding]; other site 290340007961 coenzyme A binding site [chemical binding]; other site 290340007962 catalytic triad [active] 290340007963 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 290340007964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340007965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007966 homodimer interface [polypeptide binding]; other site 290340007967 catalytic residue [active] 290340007968 Ferredoxin [Energy production and conversion]; Region: COG1146 290340007969 4Fe-4S binding domain; Region: Fer4; cl02805 290340007970 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290340007971 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 290340007972 G1 box; other site 290340007973 putative GEF interaction site [polypeptide binding]; other site 290340007974 GTP/Mg2+ binding site [chemical binding]; other site 290340007975 Switch I region; other site 290340007976 G2 box; other site 290340007977 G3 box; other site 290340007978 Switch II region; other site 290340007979 G4 box; other site 290340007980 G5 box; other site 290340007981 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290340007982 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290340007983 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 290340007984 active site 290340007985 catalytic triad [active] 290340007986 oxyanion hole [active] 290340007987 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340007988 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340007989 Walker A/P-loop; other site 290340007990 ATP binding site [chemical binding]; other site 290340007991 Q-loop/lid; other site 290340007992 ABC transporter signature motif; other site 290340007993 Walker B; other site 290340007994 D-loop; other site 290340007995 H-loop/switch region; other site 290340007996 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340007997 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340007998 Walker A/P-loop; other site 290340007999 ATP binding site [chemical binding]; other site 290340008000 Q-loop/lid; other site 290340008001 ABC transporter signature motif; other site 290340008002 Walker B; other site 290340008003 D-loop; other site 290340008004 H-loop/switch region; other site 290340008005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340008006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340008007 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290340008008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008009 dimer interface [polypeptide binding]; other site 290340008010 conserved gate region; other site 290340008011 putative PBP binding loops; other site 290340008012 ABC-ATPase subunit interface; other site 290340008013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008015 dimer interface [polypeptide binding]; other site 290340008016 conserved gate region; other site 290340008017 putative PBP binding loops; other site 290340008018 ABC-ATPase subunit interface; other site 290340008019 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340008020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290340008021 GTP-binding protein YchF; Reviewed; Region: PRK09601 290340008022 YchF GTPase; Region: YchF; cd01900 290340008023 G1 box; other site 290340008024 GTP/Mg2+ binding site [chemical binding]; other site 290340008025 Switch I region; other site 290340008026 G2 box; other site 290340008027 Switch II region; other site 290340008028 G3 box; other site 290340008029 G4 box; other site 290340008030 G5 box; other site 290340008031 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290340008032 RmuC family; Region: RmuC; pfam02646 290340008033 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290340008034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290340008035 generic binding surface II; other site 290340008036 generic binding surface I; other site 290340008037 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 290340008038 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 290340008039 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290340008040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340008041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008042 homodimer interface [polypeptide binding]; other site 290340008043 catalytic residue [active] 290340008044 NMT1-like family; Region: NMT1_2; cl15260 290340008045 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290340008046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340008047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008048 dimer interface [polypeptide binding]; other site 290340008049 conserved gate region; other site 290340008050 ABC-ATPase subunit interface; other site 290340008051 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290340008052 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 290340008053 Walker A/P-loop; other site 290340008054 ATP binding site [chemical binding]; other site 290340008055 Q-loop/lid; other site 290340008056 ABC transporter signature motif; other site 290340008057 Walker B; other site 290340008058 D-loop; other site 290340008059 H-loop/switch region; other site 290340008060 GTPase RsgA; Reviewed; Region: PRK01889 290340008061 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290340008062 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290340008063 GTP/Mg2+ binding site [chemical binding]; other site 290340008064 G4 box; other site 290340008065 G5 box; other site 290340008066 G1 box; other site 290340008067 Switch I region; other site 290340008068 G2 box; other site 290340008069 G3 box; other site 290340008070 Switch II region; other site 290340008071 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 290340008072 nudix motif; other site 290340008073 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 290340008074 Cupin domain; Region: Cupin_2; cl09118 290340008075 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290340008076 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 290340008077 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340008078 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 290340008079 Nitronate monooxygenase; Region: NMO; pfam03060 290340008080 FMN binding site [chemical binding]; other site 290340008081 substrate binding site [chemical binding]; other site 290340008082 putative catalytic residue [active] 290340008083 Helix-turn-helix domains; Region: HTH; cl00088 290340008084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340008085 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 290340008086 putative dimerization interface [polypeptide binding]; other site 290340008087 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340008088 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 290340008089 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340008090 Helix-turn-helix domains; Region: HTH; cl00088 290340008091 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340008092 Helix-turn-helix domains; Region: HTH; cl00088 290340008093 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 290340008094 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290340008095 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 290340008096 Predicted ATPase [General function prediction only]; Region: COG1485 290340008097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340008098 Walker A motif; other site 290340008099 ATP binding site [chemical binding]; other site 290340008100 Walker B motif; other site 290340008101 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290340008102 Ferritin-like domain; Region: Ferritin; pfam00210 290340008103 ferroxidase diiron center [ion binding]; other site 290340008104 CrcB-like protein; Region: CRCB; cl09114 290340008105 CrcB-like protein; Region: CRCB; cl09114 290340008106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340008107 Helix-turn-helix domains; Region: HTH; cl00088 290340008108 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 290340008109 Helix-turn-helix domains; Region: HTH; cl00088 290340008110 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 290340008111 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340008112 Catalytic site [active] 290340008113 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290340008114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008115 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340008116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340008117 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290340008118 active site 290340008119 tetramer interface; other site 290340008120 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 290340008121 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 290340008122 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 290340008123 SAF domain; Region: SAF; cl00555 290340008124 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 290340008125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340008126 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290340008127 GMP synthase; Reviewed; Region: guaA; PRK00074 290340008128 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290340008129 AMP/PPi binding site [chemical binding]; other site 290340008130 candidate oxyanion hole; other site 290340008131 catalytic triad [active] 290340008132 potential glutamine specificity residues [chemical binding]; other site 290340008133 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290340008134 ATP Binding subdomain [chemical binding]; other site 290340008135 Ligand Binding sites [chemical binding]; other site 290340008136 Dimerization subdomain; other site 290340008137 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 290340008138 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340008139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340008140 active site 290340008141 phosphorylation site [posttranslational modification] 290340008142 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 290340008143 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290340008144 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 290340008145 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 290340008146 active site 290340008147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340008148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340008149 Walker A/P-loop; other site 290340008150 ATP binding site [chemical binding]; other site 290340008151 Q-loop/lid; other site 290340008152 ABC transporter signature motif; other site 290340008153 Walker B; other site 290340008154 D-loop; other site 290340008155 H-loop/switch region; other site 290340008156 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290340008157 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290340008158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 290340008159 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 290340008160 active site 290340008161 OpgC protein; Region: OpgC_C; cl00792 290340008162 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340008163 OpgC protein; Region: OpgC_C; cl00792 290340008164 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340008165 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 290340008166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008167 PQ loop repeat; Region: PQ-loop; cl12056 290340008168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340008169 DNA binding residues [nucleotide binding] 290340008170 dimerization interface [polypeptide binding]; other site 290340008171 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290340008172 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290340008173 ring oligomerisation interface [polypeptide binding]; other site 290340008174 ATP/Mg binding site [chemical binding]; other site 290340008175 stacking interactions; other site 290340008176 hinge regions; other site 290340008177 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290340008178 oligomerisation interface [polypeptide binding]; other site 290340008179 mobile loop; other site 290340008180 roof hairpin; other site 290340008181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340008182 S-adenosylmethionine binding site [chemical binding]; other site 290340008183 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 290340008184 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340008185 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340008186 shikimate binding site; other site 290340008187 NAD(P) binding site [chemical binding]; other site 290340008188 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 290340008189 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290340008190 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 290340008191 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 290340008192 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340008193 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 290340008194 UGMP family protein; Validated; Region: PRK09604 290340008195 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 290340008196 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 290340008197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008198 Coenzyme A binding pocket [chemical binding]; other site 290340008199 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 290340008200 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 290340008201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290340008202 alanine racemase; Reviewed; Region: alr; PRK00053 290340008203 active site 290340008204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340008205 dimer interface [polypeptide binding]; other site 290340008206 substrate binding site [chemical binding]; other site 290340008207 catalytic residues [active] 290340008208 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340008209 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 290340008210 substrate binding site [chemical binding]; other site 290340008211 ATP binding site [chemical binding]; other site 290340008212 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290340008213 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 290340008214 NAD binding site [chemical binding]; other site 290340008215 sugar binding site [chemical binding]; other site 290340008216 divalent metal binding site [ion binding]; other site 290340008217 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340008218 dimer interface [polypeptide binding]; other site 290340008219 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340008220 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340008221 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 290340008222 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290340008223 putative ADP-binding pocket [chemical binding]; other site 290340008224 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 290340008225 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 290340008226 Potassium binding sites [ion binding]; other site 290340008227 Cesium cation binding sites [ion binding]; other site 290340008228 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 290340008229 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340008230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340008231 active site 290340008232 catalytic tetrad [active] 290340008233 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 290340008234 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 290340008235 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 290340008236 catalytic site [active] 290340008237 active site 290340008238 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290340008239 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 290340008240 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 290340008241 active site 290340008242 catalytic site [active] 290340008243 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290340008244 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290340008245 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290340008246 active site 290340008247 catalytic site [active] 290340008248 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 290340008249 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290340008250 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290340008251 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290340008252 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290340008253 glutaminase active site [active] 290340008254 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290340008255 dimer interface [polypeptide binding]; other site 290340008256 active site 290340008257 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290340008258 dimer interface [polypeptide binding]; other site 290340008259 active site 290340008260 pantothenate kinase; Provisional; Region: PRK05439 290340008261 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 290340008262 ATP-binding site [chemical binding]; other site 290340008263 CoA-binding site [chemical binding]; other site 290340008264 Mg2+-binding site [ion binding]; other site 290340008265 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 290340008266 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 290340008267 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 290340008268 active site 290340008269 substrate binding site [chemical binding]; other site 290340008270 metal binding site [ion binding]; metal-binding site 290340008271 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 290340008272 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290340008273 23S rRNA interface [nucleotide binding]; other site 290340008274 L3 interface [polypeptide binding]; other site 290340008275 TadE-like protein; Region: TadE; cl10688 290340008276 TadE-like protein; Region: TadE; cl10688 290340008277 SAF domain; Region: SAF; cl00555 290340008278 AAA domain; Region: AAA_31; pfam13614 290340008279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340008280 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290340008281 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340008282 ATP binding site [chemical binding]; other site 290340008283 Walker A motif; other site 290340008284 hexamer interface [polypeptide binding]; other site 290340008285 Walker B motif; other site 290340008286 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290340008287 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 290340008288 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 290340008289 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340008290 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290340008291 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 290340008292 dimerization interface 3.5A [polypeptide binding]; other site 290340008293 active site 290340008294 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 290340008295 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290340008296 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290340008297 alphaNTD homodimer interface [polypeptide binding]; other site 290340008298 alphaNTD - beta interaction site [polypeptide binding]; other site 290340008299 alphaNTD - beta' interaction site [polypeptide binding]; other site 290340008300 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 290340008301 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 290340008302 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 290340008303 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 290340008304 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 290340008305 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290340008306 rRNA binding site [nucleotide binding]; other site 290340008307 predicted 30S ribosome binding site; other site 290340008308 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 290340008309 putative active site pocket [active] 290340008310 cleavage site 290340008311 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340008312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340008313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008315 dimer interface [polypeptide binding]; other site 290340008316 conserved gate region; other site 290340008317 putative PBP binding loops; other site 290340008318 ABC-ATPase subunit interface; other site 290340008319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008320 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340008321 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340008322 active site 290340008323 adenylate kinase; Reviewed; Region: adk; PRK00279 290340008324 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340008325 AMP-binding site [chemical binding]; other site 290340008326 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340008327 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290340008328 SecY translocase; Region: SecY; pfam00344 290340008329 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 290340008330 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290340008331 23S rRNA binding site [nucleotide binding]; other site 290340008332 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290340008333 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290340008334 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290340008335 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290340008336 23S rRNA interface [nucleotide binding]; other site 290340008337 5S rRNA interface [nucleotide binding]; other site 290340008338 L27 interface [polypeptide binding]; other site 290340008339 L5 interface [polypeptide binding]; other site 290340008340 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290340008341 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290340008342 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290340008343 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 290340008344 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290340008345 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290340008346 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290340008347 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290340008348 KOW motif; Region: KOW; cl00354 290340008349 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 290340008350 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 290340008351 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290340008352 23S rRNA interface [nucleotide binding]; other site 290340008353 putative translocon interaction site; other site 290340008354 signal recognition particle (SRP54) interaction site; other site 290340008355 L23 interface [polypeptide binding]; other site 290340008356 trigger factor interaction site; other site 290340008357 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290340008358 23S rRNA interface [nucleotide binding]; other site 290340008359 5S rRNA interface [nucleotide binding]; other site 290340008360 putative antibiotic binding site [chemical binding]; other site 290340008361 L25 interface [polypeptide binding]; other site 290340008362 L27 interface [polypeptide binding]; other site 290340008363 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290340008364 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290340008365 G-X-X-G motif; other site 290340008366 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290340008367 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290340008368 putative translocon binding site; other site 290340008369 protein-rRNA interface [nucleotide binding]; other site 290340008370 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 290340008371 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290340008372 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290340008373 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290340008374 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 290340008375 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 290340008376 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 290340008377 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 290340008378 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290340008379 elongation factor Tu; Reviewed; Region: PRK00049 290340008380 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290340008381 G1 box; other site 290340008382 GEF interaction site [polypeptide binding]; other site 290340008383 GTP/Mg2+ binding site [chemical binding]; other site 290340008384 Switch I region; other site 290340008385 G2 box; other site 290340008386 G3 box; other site 290340008387 Switch II region; other site 290340008388 G4 box; other site 290340008389 G5 box; other site 290340008390 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290340008391 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290340008392 Antibiotic Binding Site [chemical binding]; other site 290340008393 elongation factor G; Reviewed; Region: PRK00007 290340008394 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290340008395 G1 box; other site 290340008396 putative GEF interaction site [polypeptide binding]; other site 290340008397 GTP/Mg2+ binding site [chemical binding]; other site 290340008398 Switch I region; other site 290340008399 G2 box; other site 290340008400 G3 box; other site 290340008401 Switch II region; other site 290340008402 G4 box; other site 290340008403 G5 box; other site 290340008404 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290340008405 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290340008406 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290340008407 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 290340008408 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290340008409 S17 interaction site [polypeptide binding]; other site 290340008410 S8 interaction site; other site 290340008411 16S rRNA interaction site [nucleotide binding]; other site 290340008412 streptomycin interaction site [chemical binding]; other site 290340008413 23S rRNA interaction site [nucleotide binding]; other site 290340008414 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290340008415 DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387 290340008416 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290340008417 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 290340008418 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290340008419 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 290340008420 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290340008421 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290340008422 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290340008423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290340008424 DNA binding site [nucleotide binding] 290340008425 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290340008426 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290340008427 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 290340008428 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 290340008429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 290340008430 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290340008431 RPB10 interaction site [polypeptide binding]; other site 290340008432 RPB1 interaction site [polypeptide binding]; other site 290340008433 RPB11 interaction site [polypeptide binding]; other site 290340008434 RPB3 interaction site [polypeptide binding]; other site 290340008435 RPB12 interaction site [polypeptide binding]; other site 290340008436 putative acyltransferase; Provisional; Region: PRK05790 290340008437 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340008438 dimer interface [polypeptide binding]; other site 290340008439 active site 290340008440 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 290340008441 putative deacylase active site [active] 290340008442 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290340008443 core dimer interface [polypeptide binding]; other site 290340008444 peripheral dimer interface [polypeptide binding]; other site 290340008445 L10 interface [polypeptide binding]; other site 290340008446 L11 interface [polypeptide binding]; other site 290340008447 putative EF-Tu interaction site [polypeptide binding]; other site 290340008448 putative EF-G interaction site [polypeptide binding]; other site 290340008449 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290340008450 23S rRNA interface [nucleotide binding]; other site 290340008451 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 290340008452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008453 Coenzyme A binding pocket [chemical binding]; other site 290340008454 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290340008455 mRNA/rRNA interface [nucleotide binding]; other site 290340008456 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290340008457 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290340008458 23S rRNA interface [nucleotide binding]; other site 290340008459 putative thiostrepton binding site; other site 290340008460 L7/L12 interface [polypeptide binding]; other site 290340008461 L25 interface [polypeptide binding]; other site 290340008462 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290340008463 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290340008464 putative homodimer interface [polypeptide binding]; other site 290340008465 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 290340008466 aspartate aminotransferase; Provisional; Region: PRK05764 290340008467 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340008468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008469 homodimer interface [polypeptide binding]; other site 290340008470 catalytic residue [active] 290340008471 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 290340008473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340008474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340008475 DNA binding residues [nucleotide binding] 290340008476 dimerization interface [polypeptide binding]; other site 290340008477 PspC domain; Region: PspC; cl00864 290340008478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340008479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290340008480 PspC domain; Region: PspC; cl00864 290340008481 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 290340008482 active site 290340008483 ADP/pyrophosphate binding site [chemical binding]; other site 290340008484 dimerization interface [polypeptide binding]; other site 290340008485 allosteric effector site; other site 290340008486 fructose-1,6-bisphosphate binding site; other site 290340008487 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340008488 Helix-turn-helix domains; Region: HTH; cl00088 290340008489 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290340008490 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290340008491 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 290340008492 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 290340008493 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340008494 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340008495 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 290340008496 heme-binding site [chemical binding]; other site 290340008497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340008498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340008499 DNA binding site [nucleotide binding] 290340008500 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290340008501 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340008502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008503 Coenzyme A binding pocket [chemical binding]; other site 290340008504 polyphosphate kinase; Provisional; Region: PRK05443 290340008505 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290340008506 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290340008507 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 290340008508 putative domain interface [polypeptide binding]; other site 290340008509 putative active site [active] 290340008510 catalytic site [active] 290340008511 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 290340008512 putative domain interface [polypeptide binding]; other site 290340008513 putative active site [active] 290340008514 catalytic site [active] 290340008515 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290340008516 active site 290340008517 Ap6A binding site [chemical binding]; other site 290340008518 nudix motif; other site 290340008519 metal binding site [ion binding]; metal-binding site 290340008520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340008521 catalytic core [active] 290340008522 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290340008523 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 290340008524 dimerization interface [polypeptide binding]; other site 290340008525 active site 290340008526 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 290340008527 folate binding site [chemical binding]; other site 290340008528 NADP+ binding site [chemical binding]; other site 290340008529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008530 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 290340008531 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290340008532 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340008533 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340008534 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 290340008535 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 290340008536 FAD binding domain; Region: FAD_binding_4; pfam01565 290340008537 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290340008538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340008539 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 290340008540 active site 290340008541 catalytic site [active] 290340008542 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 290340008543 active site 290340008544 catalytic site [active] 290340008545 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 290340008546 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340008547 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340008548 NMT1-like family; Region: NMT1_2; cl15260 290340008549 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340008550 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290340008551 Walker A/P-loop; other site 290340008552 ATP binding site [chemical binding]; other site 290340008553 Q-loop/lid; other site 290340008554 ABC transporter signature motif; other site 290340008555 Walker B; other site 290340008556 D-loop; other site 290340008557 H-loop/switch region; other site 290340008558 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340008559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008560 putative PBP binding loops; other site 290340008561 dimer interface [polypeptide binding]; other site 290340008562 ABC-ATPase subunit interface; other site 290340008563 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290340008564 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 290340008565 active site 290340008566 iron coordination sites [ion binding]; other site 290340008567 substrate binding pocket [chemical binding]; other site 290340008568 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290340008569 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290340008570 active site 290340008571 catalytic site [active] 290340008572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008574 dimer interface [polypeptide binding]; other site 290340008575 conserved gate region; other site 290340008576 putative PBP binding loops; other site 290340008577 ABC-ATPase subunit interface; other site 290340008578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340008579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008580 dimer interface [polypeptide binding]; other site 290340008581 conserved gate region; other site 290340008582 putative PBP binding loops; other site 290340008583 ABC-ATPase subunit interface; other site 290340008584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340008585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008586 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340008587 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340008588 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 290340008589 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290340008590 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290340008591 NAD(P) binding site [chemical binding]; other site 290340008592 putative active site [active] 290340008593 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340008594 putative peptidoglycan binding site; other site 290340008595 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 290340008596 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290340008597 ATP binding site [chemical binding]; other site 290340008598 Mg++ binding site [ion binding]; other site 290340008599 motif III; other site 290340008600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340008601 nucleotide binding region [chemical binding]; other site 290340008602 ATP-binding site [chemical binding]; other site 290340008603 DbpA RNA binding domain; Region: DbpA; pfam03880 290340008604 MOSC domain; Region: MOSC; pfam03473 290340008605 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290340008606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340008607 active site 290340008608 phosphorylation site [posttranslational modification] 290340008609 intermolecular recognition site; other site 290340008610 dimerization interface [polypeptide binding]; other site 290340008611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340008612 DNA binding site [nucleotide binding] 290340008613 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 290340008614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340008615 dimer interface [polypeptide binding]; other site 290340008616 phosphorylation site [posttranslational modification] 290340008617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340008618 ATP binding site [chemical binding]; other site 290340008619 Mg2+ binding site [ion binding]; other site 290340008620 G-X-G motif; other site 290340008621 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 290340008622 Amino acid permease; Region: AA_permease_2; pfam13520 290340008623 Spore germination protein; Region: Spore_permease; cl15802 290340008624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340008625 acyl-coenzyme A oxidase; Region: PLN02526 290340008626 active site 290340008627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 290340008628 Helix-turn-helix domains; Region: HTH; cl00088 290340008629 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340008630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340008631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008633 dimer interface [polypeptide binding]; other site 290340008634 conserved gate region; other site 290340008635 putative PBP binding loops; other site 290340008636 ABC-ATPase subunit interface; other site 290340008637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008639 dimer interface [polypeptide binding]; other site 290340008640 conserved gate region; other site 290340008641 putative PBP binding loops; other site 290340008642 ABC-ATPase subunit interface; other site 290340008643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340008644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340008645 Helix-turn-helix domains; Region: HTH; cl00088 290340008646 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 290340008647 Phosphoesterase family; Region: Phosphoesterase; cl15450 290340008648 Domain of unknown function (DUF756); Region: DUF756; pfam05506 290340008649 Domain of unknown function (DUF756); Region: DUF756; pfam05506 290340008650 cystathionine gamma-synthase; Provisional; Region: PRK07811 290340008651 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340008652 homodimer interface [polypeptide binding]; other site 290340008653 substrate-cofactor binding pocket; other site 290340008654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008655 catalytic residue [active] 290340008656 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 290340008657 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340008658 dimer interface [polypeptide binding]; other site 290340008659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008660 catalytic residue [active] 290340008661 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290340008662 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340008663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340008664 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340008665 minor groove reading motif; other site 290340008666 helix-hairpin-helix signature motif; other site 290340008667 substrate binding pocket [chemical binding]; other site 290340008668 active site 290340008669 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 290340008670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340008671 Walker A/P-loop; other site 290340008672 ATP binding site [chemical binding]; other site 290340008673 Q-loop/lid; other site 290340008674 ABC transporter signature motif; other site 290340008675 Walker B; other site 290340008676 D-loop; other site 290340008677 H-loop/switch region; other site 290340008678 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340008679 AMP-binding domain protein; Validated; Region: PRK08315 290340008680 AMP-binding enzyme; Region: AMP-binding; cl15778 290340008681 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 290340008682 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340008683 catalytic residues [active] 290340008684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340008685 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 290340008686 Walker A/P-loop; other site 290340008687 ATP binding site [chemical binding]; other site 290340008688 Q-loop/lid; other site 290340008689 ABC transporter signature motif; other site 290340008690 Walker B; other site 290340008691 D-loop; other site 290340008692 H-loop/switch region; other site 290340008693 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340008694 active site 290340008695 Ion channel; Region: Ion_trans_2; cl11596 290340008696 Protein of unknown function (DUF520); Region: DUF520; cl00723 290340008697 Peptidase family M48; Region: Peptidase_M48; cl12018 290340008698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340008699 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340008700 putative substrate translocation pore; other site 290340008701 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290340008702 metal binding site 2 [ion binding]; metal-binding site 290340008703 putative DNA binding helix; other site 290340008704 metal binding site 1 [ion binding]; metal-binding site 290340008705 structural Zn2+ binding site [ion binding]; other site 290340008706 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 290340008707 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 290340008708 tetramer interface [polypeptide binding]; other site 290340008709 heme binding pocket [chemical binding]; other site 290340008710 NADPH binding site [chemical binding]; other site 290340008711 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 290340008712 amino acid transporter; Region: 2A0306; TIGR00909 290340008713 Spore germination protein; Region: Spore_permease; cl15802 290340008714 Spore germination protein; Region: Spore_permease; cl15802 290340008715 Protein of unknown function (DUF779); Region: DUF779; cl01432 290340008716 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340008717 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 290340008718 NAD binding site [chemical binding]; other site 290340008719 substrate binding site [chemical binding]; other site 290340008720 catalytic Zn binding site [ion binding]; other site 290340008721 tetramer interface [polypeptide binding]; other site 290340008722 structural Zn binding site [ion binding]; other site 290340008723 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340008724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340008725 NAD(P) binding site [chemical binding]; other site 290340008726 catalytic residues [active] 290340008727 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 290340008728 Helix-turn-helix domains; Region: HTH; cl00088 290340008729 ferredoxin-NADP+ reductase; Region: PLN02852 290340008730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008731 Predicted permeases [General function prediction only]; Region: RarD; COG2962 290340008732 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 290340008733 substrate binding site [chemical binding]; other site 290340008734 catalytic residues [active] 290340008735 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 290340008736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340008737 inhibitor-cofactor binding pocket; inhibition site 290340008738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008739 catalytic residue [active] 290340008740 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340008741 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340008742 tetrameric interface [polypeptide binding]; other site 290340008743 NAD binding site [chemical binding]; other site 290340008744 catalytic residues [active] 290340008745 substrate binding site [chemical binding]; other site 290340008746 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340008747 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340008748 Helix-turn-helix domains; Region: HTH; cl00088 290340008749 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340008750 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340008751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340008752 DNA-binding site [nucleotide binding]; DNA binding site 290340008753 FCD domain; Region: FCD; cl11656 290340008754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340008755 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340008756 active site residue [active] 290340008757 ferredoxin-NADP+ reductase; Region: PLN02852 290340008758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008760 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290340008761 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 290340008762 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290340008763 active site 290340008764 Glutaminase; Region: Glutaminase; cl00907 290340008765 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 290340008766 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340008767 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340008768 Domain of unknown function (DUF305); Region: DUF305; cl15795 290340008769 lipoprotein LpqB; Provisional; Region: PRK13616 290340008770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008771 dimer interface [polypeptide binding]; other site 290340008772 conserved gate region; other site 290340008773 putative PBP binding loops; other site 290340008774 ABC-ATPase subunit interface; other site 290340008775 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340008776 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290340008777 Walker A/P-loop; other site 290340008778 ATP binding site [chemical binding]; other site 290340008779 Q-loop/lid; other site 290340008780 ABC transporter signature motif; other site 290340008781 Walker B; other site 290340008782 D-loop; other site 290340008783 H-loop/switch region; other site 290340008784 NMT1-like family; Region: NMT1_2; cl15260 290340008785 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 290340008786 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 290340008787 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 290340008788 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 290340008789 CysD dimerization site [polypeptide binding]; other site 290340008790 G1 box; other site 290340008791 putative GEF interaction site [polypeptide binding]; other site 290340008792 GTP/Mg2+ binding site [chemical binding]; other site 290340008793 Switch I region; other site 290340008794 G2 box; other site 290340008795 G3 box; other site 290340008796 Switch II region; other site 290340008797 G4 box; other site 290340008798 G5 box; other site 290340008799 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 290340008800 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 290340008801 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 290340008802 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290340008803 Active Sites [active] 290340008804 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290340008805 Active Sites [active] 290340008806 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 290340008807 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 290340008808 putative active site [active] 290340008809 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 290340008810 putative active site [active] 290340008811 Predicted membrane protein [Function unknown]; Region: COG2860 290340008812 UPF0126 domain; Region: UPF0126; pfam03458 290340008813 UPF0126 domain; Region: UPF0126; pfam03458 290340008814 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340008815 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340008816 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290340008817 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340008818 substrate binding pocket [chemical binding]; other site 290340008819 chain length determination region; other site 290340008820 substrate-Mg2+ binding site; other site 290340008821 catalytic residues [active] 290340008822 aspartate-rich region 1; other site 290340008823 active site lid residues [active] 290340008824 aspartate-rich region 2; other site 290340008825 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290340008826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008827 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 290340008828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340008829 S-adenosylmethionine binding site [chemical binding]; other site 290340008830 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 290340008831 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290340008832 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340008833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340008834 substrate binding pocket [chemical binding]; other site 290340008835 membrane-bound complex binding site; other site 290340008836 hinge residues; other site 290340008837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008838 dimer interface [polypeptide binding]; other site 290340008839 conserved gate region; other site 290340008840 putative PBP binding loops; other site 290340008841 ABC-ATPase subunit interface; other site 290340008842 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340008843 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340008844 Walker A/P-loop; other site 290340008845 ATP binding site [chemical binding]; other site 290340008846 Q-loop/lid; other site 290340008847 ABC transporter signature motif; other site 290340008848 Walker B; other site 290340008849 D-loop; other site 290340008850 H-loop/switch region; other site 290340008851 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290340008852 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290340008853 dimer interface [polypeptide binding]; other site 290340008854 tetramer interface [polypeptide binding]; other site 290340008855 PYR/PP interface [polypeptide binding]; other site 290340008856 TPP binding site [chemical binding]; other site 290340008857 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290340008858 TPP-binding site; other site 290340008859 SOUL heme-binding protein; Region: SOUL; pfam04832 290340008860 HTH-like domain; Region: HTH_21; pfam13276 290340008861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340008862 Integrase core domain; Region: rve; cl01316 290340008863 Integrase core domain; Region: rve_3; cl15866 290340008864 Helix-turn-helix domains; Region: HTH; cl00088 290340008865 Helix-turn-helix domains; Region: HTH; cl00088 290340008866 HTH-like domain; Region: HTH_21; pfam13276 290340008867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340008868 Integrase core domain; Region: rve; cl01316 290340008869 Integrase core domain; Region: rve_3; cl15866 290340008870 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 290340008871 O-succinylbenzoate synthase; Provisional; Region: PRK02901 290340008872 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290340008873 active site 290340008874 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 290340008875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340008876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340008877 DNA binding site [nucleotide binding] 290340008878 domain linker motif; other site 290340008879 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340008880 putative dimerization interface [polypeptide binding]; other site 290340008881 putative ligand binding site [chemical binding]; other site 290340008882 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 290340008883 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340008884 substrate binding [chemical binding]; other site 290340008885 active site 290340008886 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008888 dimer interface [polypeptide binding]; other site 290340008889 conserved gate region; other site 290340008890 putative PBP binding loops; other site 290340008891 ABC-ATPase subunit interface; other site 290340008892 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340008893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340008894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008895 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340008896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008897 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 290340008898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340008899 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340008900 active site 290340008901 catalytic triad [active] 290340008902 S-layer homology domain; Region: SLH; pfam00395 290340008903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340008904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340008905 putative substrate translocation pore; other site 290340008906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340008907 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 290340008908 S-layer homology domain; Region: SLH; pfam00395 290340008909 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 290340008910 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 290340008911 S-layer homology domain; Region: SLH; pfam00395 290340008912 S-layer homology domain; Region: SLH; pfam00395 290340008913 Cadherin repeat-like domain; Region: CA_like; cl15786 290340008914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290340008915 binding surface 290340008916 TPR motif; other site 290340008917 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340008918 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340008919 S-layer homology domain; Region: SLH; pfam00395 290340008920 S-layer homology domain; Region: SLH; pfam00395 290340008921 S-layer homology domain; Region: SLH; pfam00395 290340008922 Cation efflux family; Region: Cation_efflux; cl00316 290340008923 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 290340008924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340008925 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340008926 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340008927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340008928 Transporter associated domain; Region: CorC_HlyC; cl08393 290340008929 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340008930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340008931 S-layer homology domain; Region: SLH; pfam00395 290340008932 ribonuclease E; Reviewed; Region: rne; PRK10811 290340008933 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008934 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008935 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008936 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008937 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008938 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008939 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008940 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340008941 active site 290340008942 catalytic triad [active] 290340008943 S-layer homology domain; Region: SLH; pfam00395 290340008944 S-layer homology domain; Region: SLH; pfam00395 290340008945 S-layer homology domain; Region: SLH; pfam00395 290340008946 S-layer homology domain; Region: SLH; pfam00395 290340008947 S-layer homology domain; Region: SLH; pfam00395 290340008948 S-layer homology domain; Region: SLH; pfam00395 290340008949 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008950 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008951 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008952 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008953 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008954 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008955 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340008956 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008957 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340008958 Cupin domain; Region: Cupin_2; cl09118 290340008959 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 290340008960 Cupin domain; Region: Cupin_2; cl09118 290340008961 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290340008962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340008963 Helix-turn-helix domains; Region: HTH; cl00088 290340008964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 290340008965 HTH-like domain; Region: HTH_21; pfam13276 290340008966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340008967 Integrase core domain; Region: rve; cl01316 290340008968 Integrase core domain; Region: rve_3; cl15866 290340008969 Helix-turn-helix domains; Region: HTH; cl00088 290340008970 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340008971 E3 interaction surface; other site 290340008972 lipoyl attachment site [posttranslational modification]; other site 290340008973 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340008974 e3 binding domain; Region: E3_binding; pfam02817 290340008975 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 290340008976 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340008977 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340008978 alpha subunit interface [polypeptide binding]; other site 290340008979 TPP binding site [chemical binding]; other site 290340008980 heterodimer interface [polypeptide binding]; other site 290340008981 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340008982 Helix-turn-helix domains; Region: HTH; cl00088 290340008983 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290340008984 putative active site [active] 290340008985 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290340008986 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290340008987 substrate binding site; other site 290340008988 tetramer interface; other site 290340008989 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290340008990 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290340008991 NAD binding site [chemical binding]; other site 290340008992 substrate binding site [chemical binding]; other site 290340008993 homodimer interface [polypeptide binding]; other site 290340008994 active site 290340008995 Cupin domain; Region: Cupin_2; cl09118 290340008996 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290340008997 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 290340008998 NADP binding site [chemical binding]; other site 290340008999 active site 290340009000 putative substrate binding site [chemical binding]; other site 290340009001 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290340009002 Chain length determinant protein; Region: Wzz; cl15801 290340009003 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290340009004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009005 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340009008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340009009 active site 290340009010 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009011 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 290340009012 putative ADP-binding pocket [chemical binding]; other site 290340009013 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340009014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009015 Bacterial sugar transferase; Region: Bac_transf; cl00939 290340009016 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340009017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009018 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340009019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009020 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 290340009021 HTH-like domain; Region: HTH_21; pfam13276 290340009022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009023 Integrase core domain; Region: rve; cl01316 290340009024 Integrase core domain; Region: rve_3; cl15866 290340009025 Helix-turn-helix domains; Region: HTH; cl00088 290340009026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340009027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340009028 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340009029 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 290340009030 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340009031 putative di-iron ligands [ion binding]; other site 290340009032 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290340009033 FAD binding pocket [chemical binding]; other site 290340009034 FAD binding motif [chemical binding]; other site 290340009035 phosphate binding motif [ion binding]; other site 290340009036 beta-alpha-beta structure motif; other site 290340009037 NAD binding pocket [chemical binding]; other site 290340009038 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340009039 catalytic loop [active] 290340009040 iron binding site [ion binding]; other site 290340009041 LabA_like proteins; Region: LabA_like; cd06167 290340009042 putative metal binding site [ion binding]; other site 290340009043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340009044 phosphopeptide binding site; other site 290340009045 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 290340009046 penicillin-binding protein 2; Provisional; Region: PRK10795 290340009047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340009048 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 290340009049 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 290340009050 active site 290340009051 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340009052 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340009053 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 290340009054 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 290340009055 FG-GAP repeat; Region: FG-GAP; cl15299 290340009056 Family description; Region: VCBS; pfam13517 290340009057 FG-GAP repeat; Region: FG-GAP; cl15299 290340009058 Family description; Region: VCBS; pfam13517 290340009059 Helix-turn-helix domains; Region: HTH; cl00088 290340009060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340009061 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 290340009062 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 290340009063 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340009064 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340009065 active site 290340009066 catalytic triad [active] 290340009067 S-layer homology domain; Region: SLH; pfam00395 290340009068 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340009069 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340009070 S-layer homology domain; Region: SLH; pfam00395 290340009071 S-layer homology domain; Region: SLH; pfam00395 290340009072 S-layer homology domain; Region: SLH; pfam00395 290340009073 Protein of unknown function DUF262; Region: DUF262; cl14890 290340009074 S-layer homology domain; Region: SLH; pfam00395 290340009075 S-layer homology domain; Region: SLH; pfam00395 290340009076 Excalibur calcium-binding domain; Region: Excalibur; cl05460 290340009077 S-layer homology domain; Region: SLH; pfam00395 290340009078 S-layer homology domain; Region: SLH; pfam00395 290340009079 S-layer homology domain; Region: SLH; pfam00395 290340009080 S-layer homology domain; Region: SLH; pfam00395 290340009081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340009082 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 290340009083 active site 290340009084 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 290340009085 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 290340009086 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 290340009087 enoyl-CoA hydratase; Provisional; Region: PRK08140 290340009088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009089 substrate binding site [chemical binding]; other site 290340009090 oxyanion hole (OAH) forming residues; other site 290340009091 trimer interface [polypeptide binding]; other site 290340009092 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 290340009093 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 290340009094 FAD binding pocket [chemical binding]; other site 290340009095 FAD binding motif [chemical binding]; other site 290340009096 phosphate binding motif [ion binding]; other site 290340009097 beta-alpha-beta structure motif; other site 290340009098 NAD(p) ribose binding residues [chemical binding]; other site 290340009099 NAD binding pocket [chemical binding]; other site 290340009100 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 290340009101 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340009102 catalytic loop [active] 290340009103 iron binding site [ion binding]; other site 290340009104 Domain of unknown function DUF59; Region: DUF59; cl00941 290340009105 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 290340009106 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 290340009107 Phenylacetic acid degradation B; Region: PaaB; cl01371 290340009108 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 290340009109 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 290340009110 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340009111 active site 290340009112 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340009113 putative peptidoglycan binding site; other site 290340009114 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 290340009115 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 290340009116 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340009117 Catalytic site [active] 290340009118 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 290340009119 VanZ like family; Region: VanZ; cl01971 290340009120 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290340009121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290340009122 putative active site [active] 290340009123 heme pocket [chemical binding]; other site 290340009124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340009125 dimer interface [polypeptide binding]; other site 290340009126 phosphorylation site [posttranslational modification] 290340009127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009128 ATP binding site [chemical binding]; other site 290340009129 Mg2+ binding site [ion binding]; other site 290340009130 G-X-G motif; other site 290340009131 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009133 active site 290340009134 phosphorylation site [posttranslational modification] 290340009135 intermolecular recognition site; other site 290340009136 dimerization interface [polypeptide binding]; other site 290340009137 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009139 active site 290340009140 phosphorylation site [posttranslational modification] 290340009141 intermolecular recognition site; other site 290340009142 dimerization interface [polypeptide binding]; other site 290340009143 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009145 active site 290340009146 phosphorylation site [posttranslational modification] 290340009147 intermolecular recognition site; other site 290340009148 dimerization interface [polypeptide binding]; other site 290340009149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340009150 metal binding site [ion binding]; metal-binding site 290340009151 active site 290340009152 I-site; other site 290340009153 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 290340009154 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340009155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009156 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290340009157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340009158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340009159 dimer interface [polypeptide binding]; other site 290340009160 phosphorylation site [posttranslational modification] 290340009161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009162 ATP binding site [chemical binding]; other site 290340009163 Mg2+ binding site [ion binding]; other site 290340009164 G-X-G motif; other site 290340009165 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 290340009166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340009167 metal binding site [ion binding]; metal-binding site 290340009168 active site 290340009169 I-site; other site 290340009170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340009171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340009172 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340009173 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290340009174 CoenzymeA binding site [chemical binding]; other site 290340009175 subunit interaction site [polypeptide binding]; other site 290340009176 PHB binding site; other site 290340009177 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 290340009178 AMP-binding enzyme; Region: AMP-binding; cl15778 290340009179 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 290340009180 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 290340009181 substrate binding site [chemical binding]; other site 290340009182 dimer interface [polypeptide binding]; other site 290340009183 NADP binding site [chemical binding]; other site 290340009184 catalytic residues [active] 290340009185 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340009186 active site 2 [active] 290340009187 active site 1 [active] 290340009188 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340009189 S-layer homology domain; Region: SLH; pfam00395 290340009190 S-layer homology domain; Region: SLH; pfam00395 290340009191 S-layer homology domain; Region: SLH; pfam00395 290340009192 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340009193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340009194 active site 290340009195 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340009196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009198 DNA binding site [nucleotide binding] 290340009199 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340009200 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009203 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340009204 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009206 dimer interface [polypeptide binding]; other site 290340009207 conserved gate region; other site 290340009208 putative PBP binding loops; other site 290340009209 ABC-ATPase subunit interface; other site 290340009210 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 290340009211 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009213 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340009214 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 290340009215 active site 290340009216 catalytic triad [active] 290340009217 oxyanion hole [active] 290340009218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340009219 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 290340009220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009221 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340009222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009223 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290340009224 substrate binding site [chemical binding]; other site 290340009225 oxyanion hole (OAH) forming residues; other site 290340009226 trimer interface [polypeptide binding]; other site 290340009227 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 290340009228 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340009229 dimer interface [polypeptide binding]; other site 290340009230 active site 290340009231 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290340009232 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290340009233 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290340009234 hydrophobic ligand binding site; other site 290340009235 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290340009236 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340009237 iron-sulfur cluster [ion binding]; other site 290340009238 [2Fe-2S] cluster binding site [ion binding]; other site 290340009239 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290340009240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340009241 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 290340009242 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290340009243 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340009244 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340009245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009246 D-loop; other site 290340009247 H-loop/switch region; other site 290340009248 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340009249 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 290340009250 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340009251 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340009252 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340009253 ABC-ATPase subunit interface; other site 290340009254 dimer interface [polypeptide binding]; other site 290340009255 putative PBP binding regions; other site 290340009256 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340009257 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 290340009258 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290340009259 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290340009260 metal binding site [ion binding]; metal-binding site 290340009261 CAAX protease self-immunity; Region: Abi; cl00558 290340009262 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340009263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009264 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290340009265 substrate binding site [chemical binding]; other site 290340009266 oxyanion hole (OAH) forming residues; other site 290340009267 trimer interface [polypeptide binding]; other site 290340009268 AMP-binding enzyme; Region: AMP-binding; cl15778 290340009269 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 290340009270 UbiA prenyltransferase family; Region: UbiA; cl00337 290340009271 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 290340009272 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340009273 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290340009274 GTP-binding protein Der; Reviewed; Region: PRK00093 290340009275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009276 Dynamin family; Region: Dynamin_N; pfam00350 290340009277 G1 box; other site 290340009278 GTP/Mg2+ binding site [chemical binding]; other site 290340009279 G2 box; other site 290340009280 Switch I region; other site 290340009281 G3 box; other site 290340009282 Switch II region; other site 290340009283 G4 box; other site 290340009284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009285 Dynamin family; Region: Dynamin_N; pfam00350 290340009286 G1 box; other site 290340009287 GTP/Mg2+ binding site [chemical binding]; other site 290340009288 G2 box; other site 290340009289 Switch I region; other site 290340009290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009291 G3 box; other site 290340009292 Switch II region; other site 290340009293 GTP/Mg2+ binding site [chemical binding]; other site 290340009294 G4 box; other site 290340009295 G5 box; other site 290340009296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340009297 DNA binding residues [nucleotide binding] 290340009298 dimerization interface [polypeptide binding]; other site 290340009299 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 290340009300 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290340009301 ResB-like family; Region: ResB; pfam05140 290340009302 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340009303 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340009304 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340009305 catalytic residues [active] 290340009306 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340009307 catalytic core [active] 290340009308 YceI-like domain; Region: YceI; cl01001 290340009309 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 290340009310 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 290340009311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009312 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340009313 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290340009314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340009315 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340009316 Helix-turn-helix domains; Region: HTH; cl00088 290340009317 HTH-like domain; Region: HTH_21; pfam13276 290340009318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009319 Integrase core domain; Region: rve; cl01316 290340009320 Integrase core domain; Region: rve_3; cl15866 290340009321 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340009322 NeuB family; Region: NeuB; cl00496 290340009323 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290340009324 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 290340009325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009327 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340009328 Transmembrane secretion effector; Region: MFS_3; pfam05977 290340009329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009332 dimer interface [polypeptide binding]; other site 290340009333 conserved gate region; other site 290340009334 putative PBP binding loops; other site 290340009335 ABC-ATPase subunit interface; other site 290340009336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009338 dimer interface [polypeptide binding]; other site 290340009339 putative PBP binding loops; other site 290340009340 ABC-ATPase subunit interface; other site 290340009341 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009343 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340009344 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 290340009345 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340009346 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340009347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009351 dimer interface [polypeptide binding]; other site 290340009352 conserved gate region; other site 290340009353 putative PBP binding loops; other site 290340009354 ABC-ATPase subunit interface; other site 290340009355 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009357 dimer interface [polypeptide binding]; other site 290340009358 conserved gate region; other site 290340009359 putative PBP binding loops; other site 290340009360 ABC-ATPase subunit interface; other site 290340009361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009363 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340009364 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290340009365 active site 290340009366 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 290340009367 dimer interface [polypeptide binding]; other site 290340009368 NADP binding site [chemical binding]; other site 290340009369 catalytic residues [active] 290340009370 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340009371 active site pocket [active] 290340009372 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340009373 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290340009374 catalytic residue [active] 290340009375 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340009376 extended (e) SDRs; Region: SDR_e; cd08946 290340009377 NAD(P) binding site [chemical binding]; other site 290340009378 active site 290340009379 substrate binding site [chemical binding]; other site 290340009380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009381 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340009382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009384 DNA binding site [nucleotide binding] 290340009385 domain linker motif; other site 290340009386 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340009387 dimerization interface [polypeptide binding]; other site 290340009388 ligand binding site [chemical binding]; other site 290340009389 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340009390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340009391 DNA-binding site [nucleotide binding]; DNA binding site 290340009392 FCD domain; Region: FCD; cl11656 290340009393 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 290340009394 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290340009395 phosphate binding site [ion binding]; other site 290340009396 glutamate dehydrogenase; Provisional; Region: PRK09414 290340009397 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290340009398 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 290340009399 NAD(P) binding site [chemical binding]; other site 290340009400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340009401 dimerization interface [polypeptide binding]; other site 290340009402 putative DNA binding site [nucleotide binding]; other site 290340009403 putative Zn2+ binding site [ion binding]; other site 290340009404 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 290340009405 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 290340009406 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290340009407 Cation transport protein; Region: TrkH; cl10514 290340009408 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340009409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 290340009411 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290340009412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009413 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340009414 AP (apurinic/apyrimidinic) site pocket; other site 290340009415 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340009416 Metal-binding active site; metal-binding site 290340009417 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 290340009418 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 290340009419 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290340009420 active site 290340009421 interdomain interaction site; other site 290340009422 putative metal-binding site [ion binding]; other site 290340009423 nucleotide binding site [chemical binding]; other site 290340009424 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290340009425 domain I; other site 290340009426 DNA binding groove [nucleotide binding] 290340009427 phosphate binding site [ion binding]; other site 290340009428 domain II; other site 290340009429 domain III; other site 290340009430 nucleotide binding site [chemical binding]; other site 290340009431 catalytic site [active] 290340009432 domain IV; other site 290340009433 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009434 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009435 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340009437 dimerization interface [polypeptide binding]; other site 290340009438 putative DNA binding site [nucleotide binding]; other site 290340009439 putative Zn2+ binding site [ion binding]; other site 290340009440 HemK family putative methylases; Region: hemK_fam; TIGR00536 290340009441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340009442 S-adenosylmethionine binding site [chemical binding]; other site 290340009443 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 290340009444 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 290340009445 active site residue [active] 290340009446 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340009447 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 290340009448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340009449 ATP binding site [chemical binding]; other site 290340009450 putative Mg++ binding site [ion binding]; other site 290340009451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340009452 nucleotide binding region [chemical binding]; other site 290340009453 ATP-binding site [chemical binding]; other site 290340009454 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 290340009455 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 290340009456 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 290340009457 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009458 Walker A motif; other site 290340009459 ATP binding site [chemical binding]; other site 290340009460 Walker B motif; other site 290340009461 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 290340009462 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 290340009463 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 290340009464 active site 290340009465 DNA binding site [nucleotide binding] 290340009466 catalytic site [active] 290340009467 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290340009468 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 290340009469 putative active site [active] 290340009470 putative CoA binding site [chemical binding]; other site 290340009471 nudix motif; other site 290340009472 metal binding site [ion binding]; metal-binding site 290340009473 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 290340009474 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340009475 minor groove reading motif; other site 290340009476 helix-hairpin-helix signature motif; other site 290340009477 substrate binding pocket [chemical binding]; other site 290340009478 active site 290340009479 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 290340009480 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340009481 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290340009482 AMP-binding enzyme; Region: AMP-binding; cl15778 290340009483 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340009484 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340009485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340009486 DNA-binding site [nucleotide binding]; DNA binding site 290340009487 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340009488 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340009489 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290340009490 Walker A/P-loop; other site 290340009491 ATP binding site [chemical binding]; other site 290340009492 Q-loop/lid; other site 290340009493 ABC transporter signature motif; other site 290340009494 Walker B; other site 290340009495 D-loop; other site 290340009496 H-loop/switch region; other site 290340009497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009499 DNA binding site [nucleotide binding] 290340009500 domain linker motif; other site 290340009501 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340009502 dimerization interface [polypeptide binding]; other site 290340009503 ligand binding site [chemical binding]; other site 290340009504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009507 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009509 dimer interface [polypeptide binding]; other site 290340009510 conserved gate region; other site 290340009511 putative PBP binding loops; other site 290340009512 ABC-ATPase subunit interface; other site 290340009513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009515 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 290340009516 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 290340009517 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290340009518 trimer interface [polypeptide binding]; other site 290340009519 active site 290340009520 dimer interface [polypeptide binding]; other site 290340009521 Colicin V production protein; Region: Colicin_V; cl00567 290340009522 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340009523 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290340009524 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290340009525 ligand binding site [chemical binding]; other site 290340009526 flexible hinge region; other site 290340009527 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290340009528 putative switch regulator; other site 290340009529 non-specific DNA interactions [nucleotide binding]; other site 290340009530 DNA binding site [nucleotide binding] 290340009531 sequence specific DNA binding site [nucleotide binding]; other site 290340009532 putative cAMP binding site [chemical binding]; other site 290340009533 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290340009534 homotrimer interaction site [polypeptide binding]; other site 290340009535 putative active site [active] 290340009536 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 290340009537 Transglycosylase; Region: Transgly; cl07896 290340009538 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290340009539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340009540 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 290340009541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290340009542 putative active site [active] 290340009543 putative metal binding site [ion binding]; other site 290340009544 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340009545 Helix-turn-helix domains; Region: HTH; cl00088 290340009546 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 290340009547 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340009548 active site 290340009549 hypothetical protein; Provisional; Region: PRK06184 290340009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009551 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 290340009552 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340009553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340009554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340009555 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340009556 active site 290340009557 catalytic tetrad [active] 290340009558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340009559 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340009560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009561 Walker A/P-loop; other site 290340009562 ATP binding site [chemical binding]; other site 290340009563 Q-loop/lid; other site 290340009564 ABC transporter signature motif; other site 290340009565 Walker B; other site 290340009566 D-loop; other site 290340009567 H-loop/switch region; other site 290340009568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340009569 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340009570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009571 Walker A/P-loop; other site 290340009572 ATP binding site [chemical binding]; other site 290340009573 Q-loop/lid; other site 290340009574 ABC transporter signature motif; other site 290340009575 Walker B; other site 290340009576 D-loop; other site 290340009577 H-loop/switch region; other site 290340009578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340009579 non-specific DNA binding site [nucleotide binding]; other site 290340009580 salt bridge; other site 290340009581 sequence-specific DNA binding site [nucleotide binding]; other site 290340009582 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 290340009583 ATP binding site [chemical binding]; other site 290340009584 active site 290340009585 substrate binding site [chemical binding]; other site 290340009586 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290340009587 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290340009588 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340009589 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290340009590 L-asparaginase II; Region: Asparaginase_II; cl01842 290340009591 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290340009592 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290340009593 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 290340009594 classical (c) SDRs; Region: SDR_c; cd05233 290340009595 NAD(P) binding site [chemical binding]; other site 290340009596 active site 290340009597 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290340009598 Sodium:solute symporter family; Region: SSF; cl00456 290340009599 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290340009600 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290340009601 dimer interface [polypeptide binding]; other site 290340009602 TPP-binding site [chemical binding]; other site 290340009603 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 290340009604 metal-binding site 290340009605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340009606 Coenzyme A binding pocket [chemical binding]; other site 290340009607 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 290340009608 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290340009609 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 290340009610 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 290340009611 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290340009612 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 290340009613 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290340009614 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290340009615 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340009616 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340009617 nucleoside/Zn binding site; other site 290340009618 dimer interface [polypeptide binding]; other site 290340009619 catalytic motif [active] 290340009620 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340009621 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340009622 active site 290340009623 putative substrate binding pocket [chemical binding]; other site 290340009624 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 290340009625 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340009626 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340009627 putative active site [active] 290340009628 urate oxidase; Region: urate_oxi; TIGR03383 290340009629 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290340009630 active site 290340009631 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 290340009632 xanthine permease; Region: pbuX; TIGR03173 290340009633 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290340009634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340009635 Helix-turn-helix domains; Region: HTH; cl00088 290340009636 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340009637 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290340009638 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290340009639 putative NAD(P) binding site [chemical binding]; other site 290340009640 malate synthase A; Region: malate_syn_A; TIGR01344 290340009641 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290340009642 active site 290340009643 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340009644 hypothetical protein; Provisional; Region: PRK11171 290340009645 Cupin domain; Region: Cupin_2; cl09118 290340009646 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340009647 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 290340009648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009649 benzoate transport; Region: 2A0115; TIGR00895 290340009650 putative substrate translocation pore; other site 290340009651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009652 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290340009653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009654 ATP binding site [chemical binding]; other site 290340009655 Mg2+ binding site [ion binding]; other site 290340009656 G-X-G motif; other site 290340009657 Transglycosylase; Region: Transgly; cl07896 290340009658 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290340009659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340009660 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340009661 catalytic triad [active] 290340009662 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340009663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009664 putative substrate translocation pore; other site 290340009665 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290340009666 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 290340009667 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340009668 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340009669 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 290340009670 active site clefts [active] 290340009671 zinc binding site [ion binding]; other site 290340009672 dimer interface [polypeptide binding]; other site 290340009673 FG-GAP repeat; Region: FG-GAP; cl15299 290340009674 Family description; Region: VCBS; pfam13517 290340009675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340009676 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340009677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009678 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340009679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340009680 active site 290340009681 adenylate kinase; Reviewed; Region: adk; PRK00279 290340009682 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340009683 AMP-binding site [chemical binding]; other site 290340009684 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340009685 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340009686 putative hydrophobic ligand binding site [chemical binding]; other site 290340009687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340009688 dimerization interface [polypeptide binding]; other site 290340009689 putative DNA binding site [nucleotide binding]; other site 290340009690 putative Zn2+ binding site [ion binding]; other site 290340009691 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290340009692 putative active site [active] 290340009693 benzoate transport; Region: 2A0115; TIGR00895 290340009694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009695 putative substrate translocation pore; other site 290340009696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009697 GAF domain; Region: GAF; cl15785 290340009698 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290340009699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340009700 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 290340009701 active site 290340009702 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290340009703 putative hydrophobic ligand binding site [chemical binding]; other site 290340009704 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 290340009705 metal binding site [ion binding]; metal-binding site 290340009706 active site 290340009707 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340009708 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340009709 Walker A/P-loop; other site 290340009710 ATP binding site [chemical binding]; other site 290340009711 Q-loop/lid; other site 290340009712 ABC transporter signature motif; other site 290340009713 Walker B; other site 290340009714 D-loop; other site 290340009715 H-loop/switch region; other site 290340009716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340009717 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340009718 Walker A/P-loop; other site 290340009719 ATP binding site [chemical binding]; other site 290340009720 Q-loop/lid; other site 290340009721 ABC transporter signature motif; other site 290340009722 Walker B; other site 290340009723 D-loop; other site 290340009724 H-loop/switch region; other site 290340009725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340009726 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340009727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009728 ABC-ATPase subunit interface; other site 290340009729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340009730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009731 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 290340009732 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340009733 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340009734 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340009735 active site 290340009736 non-prolyl cis peptide bond; other site 290340009737 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340009738 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340009739 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340009740 active site residue [active] 290340009741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009742 putative substrate translocation pore; other site 290340009743 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290340009744 active site 290340009745 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 290340009746 dimer interface [polypeptide binding]; other site 290340009747 non-prolyl cis peptide bond; other site 290340009748 insertion regions; other site 290340009749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009750 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 290340009751 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290340009752 Walker A/P-loop; other site 290340009753 ATP binding site [chemical binding]; other site 290340009754 Q-loop/lid; other site 290340009755 ABC transporter signature motif; other site 290340009756 Walker B; other site 290340009757 D-loop; other site 290340009758 H-loop/switch region; other site 290340009759 NMT1-like family; Region: NMT1_2; cl15260 290340009760 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340009761 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340009762 active site 290340009763 non-prolyl cis peptide bond; other site 290340009764 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340009765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340009766 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290340009767 DXD motif; other site 290340009768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340009769 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 290340009770 active site 290340009771 catalytic residues [active] 290340009772 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340009773 nudix motif; other site 290340009774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340009775 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340009776 MOSC domain; Region: MOSC; pfam03473 290340009777 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340009778 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 290340009779 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340009780 Walker A/P-loop; other site 290340009781 ATP binding site [chemical binding]; other site 290340009782 Q-loop/lid; other site 290340009783 ABC transporter signature motif; other site 290340009784 Walker B; other site 290340009785 D-loop; other site 290340009786 H-loop/switch region; other site 290340009787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340009788 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290340009789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009790 Walker A/P-loop; other site 290340009791 ATP binding site [chemical binding]; other site 290340009792 Q-loop/lid; other site 290340009793 ABC transporter signature motif; other site 290340009794 Walker B; other site 290340009795 D-loop; other site 290340009796 H-loop/switch region; other site 290340009797 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340009798 Helix-turn-helix domains; Region: HTH; cl00088 290340009799 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340009800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340009801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340009802 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 290340009803 putative active site; other site 290340009804 putative metal binding residues [ion binding]; other site 290340009805 signature motif; other site 290340009806 putative triphosphate binding site [ion binding]; other site 290340009807 CHAD domain; Region: CHAD; cl10506 290340009808 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290340009809 putative hydrophobic ligand binding site [chemical binding]; other site 290340009810 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340009811 Helix-turn-helix domains; Region: HTH; cl00088 290340009812 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340009813 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340009814 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340009815 enoyl-CoA hydratase; Provisional; Region: PRK06688 290340009816 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009817 substrate binding site [chemical binding]; other site 290340009818 oxyanion hole (OAH) forming residues; other site 290340009819 trimer interface [polypeptide binding]; other site 290340009820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009821 thymidylate kinase; Validated; Region: tmk; PRK00698 290340009822 active site 290340009823 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340009824 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340009825 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 290340009826 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340009827 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 290340009828 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 290340009829 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 290340009830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009831 Walker A/P-loop; other site 290340009832 ATP binding site [chemical binding]; other site 290340009833 Q-loop/lid; other site 290340009834 ABC transporter signature motif; other site 290340009835 Walker B; other site 290340009836 D-loop; other site 290340009837 H-loop/switch region; other site 290340009838 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290340009839 active site 290340009840 putative substrate binding region [chemical binding]; other site 290340009841 YcaO-like family; Region: YcaO; pfam02624 290340009842 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 290340009843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009844 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340009845 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340009846 active site 290340009847 NAD binding site [chemical binding]; other site 290340009848 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 290340009849 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340009850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340009851 catalytic residue [active] 290340009852 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340009853 conserved cys residue [active] 290340009854 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009856 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340009857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009859 dimer interface [polypeptide binding]; other site 290340009860 conserved gate region; other site 290340009861 putative PBP binding loops; other site 290340009862 ABC-ATPase subunit interface; other site 290340009863 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009865 dimer interface [polypeptide binding]; other site 290340009866 conserved gate region; other site 290340009867 putative PBP binding loops; other site 290340009868 ABC-ATPase subunit interface; other site 290340009869 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340009870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009871 uridine kinase; Validated; Region: PRK06696 290340009872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009873 active site 290340009874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009876 DNA binding site [nucleotide binding] 290340009877 domain linker motif; other site 290340009878 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290340009879 ligand binding site [chemical binding]; other site 290340009880 dimerization interface [polypeptide binding]; other site 290340009881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009882 AAA domain; Region: AAA_21; pfam13304 290340009883 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 290340009884 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 290340009885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340009886 glyoxylate carboligase; Provisional; Region: PRK11269 290340009887 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340009888 PYR/PP interface [polypeptide binding]; other site 290340009889 dimer interface [polypeptide binding]; other site 290340009890 TPP binding site [chemical binding]; other site 290340009891 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290340009892 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340009893 TPP-binding site [chemical binding]; other site 290340009894 Glycerate kinase family; Region: Gly_kinase; cl00841 290340009895 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 290340009896 allantoinase; Region: allantoinase; TIGR03178 290340009897 active site 290340009898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340009899 DNA binding site [nucleotide binding] 290340009900 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290340009901 catalytic triad [active] 290340009902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009903 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009904 active site 290340009905 phosphorylation site [posttranslational modification] 290340009906 intermolecular recognition site; other site 290340009907 dimerization interface [polypeptide binding]; other site 290340009908 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 290340009909 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290340009910 Cellulose synthase; Region: Cellulose_synt; pfam03552 290340009911 DXD motif; other site 290340009912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340009913 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 290340009914 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290340009915 anti sigma factor interaction site; other site 290340009916 regulatory phosphorylation site [posttranslational modification]; other site 290340009917 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290340009918 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 290340009919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340009920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340009921 catalytic residue [active] 290340009922 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340009923 Helix-turn-helix domains; Region: HTH; cl00088 290340009924 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290340009925 active site 290340009926 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 290340009927 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 290340009928 active site 290340009929 homotetramer interface [polypeptide binding]; other site 290340009930 amidophosphoribosyltransferase; Provisional; Region: PRK07847 290340009931 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290340009932 active site 290340009933 tetramer interface [polypeptide binding]; other site 290340009934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340009935 active site 290340009936 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290340009937 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290340009938 dimerization interface [polypeptide binding]; other site 290340009939 putative ATP binding site [chemical binding]; other site 290340009940 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340009941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340009942 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340009943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340009944 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340009945 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340009946 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340009947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340009948 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 290340009949 Septum formation; Region: Septum_form; pfam13845 290340009950 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290340009951 Clp amino terminal domain; Region: Clp_N; pfam02861 290340009952 Clp amino terminal domain; Region: Clp_N; pfam02861 290340009953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340009954 Walker A motif; other site 290340009955 ATP binding site [chemical binding]; other site 290340009956 Walker B motif; other site 290340009957 arginine finger; other site 290340009958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340009959 Walker A motif; other site 290340009960 ATP binding site [chemical binding]; other site 290340009961 Walker B motif; other site 290340009962 arginine finger; other site 290340009963 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290340009964 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290340009965 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 290340009966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340009967 Walker A/P-loop; other site 290340009968 ATP binding site [chemical binding]; other site 290340009969 Q-loop/lid; other site 290340009970 ABC transporter signature motif; other site 290340009971 Walker B; other site 290340009972 D-loop; other site 290340009973 H-loop/switch region; other site 290340009974 TOBE domain; Region: TOBE_2; cl01440 290340009975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009976 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290340009977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340009978 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340009979 DNA binding residues [nucleotide binding] 290340009980 TOBE domain; Region: TOBE_2; cl01440 290340009981 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290340009982 FAD binding domain; Region: FAD_binding_4; pfam01565 290340009983 Berberine and berberine like; Region: BBE; pfam08031 290340009984 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 290340009985 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290340009986 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290340009987 catalytic site [active] 290340009988 BNR repeat-like domain; Region: BNR_2; pfam13088 290340009989 Asp-box motif; other site 290340009990 hypothetical protein; Provisional; Region: PRK11770 290340009991 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290340009992 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290340009993 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340009994 putative hydrophobic ligand binding site [chemical binding]; other site 290340009995 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 290340009996 active site 290340009997 HutD; Region: HutD; cl01532 290340009998 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290340009999 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290340010000 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340010001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010002 active site 290340010003 catalytic tetrad [active] 290340010004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340010005 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290340010006 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340010007 ATP binding site [chemical binding]; other site 290340010008 Mg++ binding site [ion binding]; other site 290340010009 motif III; other site 290340010010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340010011 nucleotide binding region [chemical binding]; other site 290340010012 ATP-binding site [chemical binding]; other site 290340010013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010014 putative substrate translocation pore; other site 290340010015 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 290340010016 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 290340010017 DNA binding residues [nucleotide binding] 290340010018 dimer interface [polypeptide binding]; other site 290340010019 [2Fe-2S] cluster binding site [ion binding]; other site 290340010020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010021 S-adenosylmethionine binding site [chemical binding]; other site 290340010022 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340010023 Helix-turn-helix domains; Region: HTH; cl00088 290340010024 Helix-turn-helix domains; Region: HTH; cl00088 290340010025 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340010026 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290340010027 metal binding site [ion binding]; metal-binding site 290340010028 dimer interface [polypeptide binding]; other site 290340010029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010030 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010031 putative substrate translocation pore; other site 290340010032 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340010033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010034 putative substrate translocation pore; other site 290340010035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340010036 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340010037 hydrophobic ligand binding site; other site 290340010038 Putative zinc-finger; Region: zf-HC2; cl15806 290340010039 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 290340010040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340010042 DNA binding residues [nucleotide binding] 290340010043 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290340010044 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290340010045 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340010046 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010047 putative active site [active] 290340010048 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 290340010049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340010050 Walker A/P-loop; other site 290340010051 ATP binding site [chemical binding]; other site 290340010052 Q-loop/lid; other site 290340010053 ABC transporter signature motif; other site 290340010054 Walker B; other site 290340010055 D-loop; other site 290340010056 H-loop/switch region; other site 290340010057 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 290340010058 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 290340010059 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 290340010060 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 290340010061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340010062 ATP binding site [chemical binding]; other site 290340010063 putative Mg++ binding site [ion binding]; other site 290340010064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340010065 nucleotide binding region [chemical binding]; other site 290340010066 ATP-binding site [chemical binding]; other site 290340010067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340010068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010069 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340010070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010071 DNA-binding site [nucleotide binding]; DNA binding site 290340010072 FCD domain; Region: FCD; cl11656 290340010073 amidase; Validated; Region: PRK06565 290340010074 Amidase; Region: Amidase; cl11426 290340010075 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 290340010076 agmatine deiminase; Region: agmatine_aguA; TIGR03380 290340010077 glycogen branching enzyme; Provisional; Region: PRK14705 290340010078 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340010079 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010080 Helix-turn-helix domains; Region: HTH; cl00088 290340010081 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010082 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010083 Helix-turn-helix domains; Region: HTH; cl00088 290340010084 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010085 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340010086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010087 NAD(P) binding site [chemical binding]; other site 290340010088 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340010089 TPP-binding site [chemical binding]; other site 290340010090 dimer interface [polypeptide binding]; other site 290340010091 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340010092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340010093 PYR/PP interface [polypeptide binding]; other site 290340010094 dimer interface [polypeptide binding]; other site 290340010095 TPP binding site [chemical binding]; other site 290340010096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340010097 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340010098 ATP binding site [chemical binding]; other site 290340010099 substrate binding site [chemical binding]; other site 290340010100 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340010101 classical (c) SDRs; Region: SDR_c; cd05233 290340010102 NAD(P) binding site [chemical binding]; other site 290340010103 active site 290340010104 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340010105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010106 NAD(P) binding site [chemical binding]; other site 290340010107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010108 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010109 putative substrate translocation pore; other site 290340010110 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340010111 classical (c) SDRs; Region: SDR_c; cd05233 290340010112 NAD(P) binding site [chemical binding]; other site 290340010113 active site 290340010114 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 290340010115 DNA binding residues [nucleotide binding] 290340010116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340010117 putative dimer interface [polypeptide binding]; other site 290340010118 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290340010119 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 290340010120 ATP binding site [chemical binding]; other site 290340010121 profilin binding site; other site 290340010122 Protein of unknown function (DUF817); Region: DUF817; cl01520 290340010123 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 290340010124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340010125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010126 NAD(P) binding site [chemical binding]; other site 290340010127 active site 290340010128 Cupin domain; Region: Cupin_2; cl09118 290340010129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340010130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340010131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340010133 Phospholipid methyltransferase; Region: PEMT; cl00763 290340010134 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340010135 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290340010136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340010137 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340010138 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290340010139 PhoD-like phosphatase; Region: PhoD; pfam09423 290340010140 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290340010141 putative active site [active] 290340010142 putative metal binding site [ion binding]; other site 290340010143 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290340010144 choline dehydrogenase; Validated; Region: PRK02106 290340010145 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290340010146 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 290340010147 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 290340010148 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 290340010149 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290340010150 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 290340010151 Baseplate J-like protein; Region: Baseplate_J; cl01294 290340010152 Baseplate J-like protein; Region: Baseplate_J; cl01294 290340010153 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 290340010154 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 290340010155 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290340010156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340010157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010158 homodimer interface [polypeptide binding]; other site 290340010159 catalytic residue [active] 290340010160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340010161 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 290340010162 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 290340010163 Helix-turn-helix domains; Region: HTH; cl00088 290340010164 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340010165 LysE type translocator; Region: LysE; cl00565 290340010166 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340010167 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340010168 NAD(P) binding site [chemical binding]; other site 290340010169 catalytic residues [active] 290340010170 prephenate dehydratase; Provisional; Region: PRK11899 290340010171 Prephenate dehydratase; Region: PDT; pfam00800 290340010172 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290340010173 putative L-Phe binding site [chemical binding]; other site 290340010174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290340010175 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 290340010176 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340010177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340010178 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340010179 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340010180 active site 290340010181 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340010182 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340010183 active site 290340010184 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290340010185 amphipathic channel; other site 290340010186 Asn-Pro-Ala signature motifs; other site 290340010187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340010188 dimerization interface [polypeptide binding]; other site 290340010189 putative DNA binding site [nucleotide binding]; other site 290340010190 putative Zn2+ binding site [ion binding]; other site 290340010191 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290340010192 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340010193 MMPL family; Region: MMPL; pfam03176 290340010194 Protein export membrane protein; Region: SecD_SecF; cl14618 290340010195 Transport protein; Region: actII; TIGR00833 290340010196 Helix-turn-helix domains; Region: HTH; cl00088 290340010197 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340010198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290340010199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010200 S-adenosylmethionine binding site [chemical binding]; other site 290340010201 YCII-related domain; Region: YCII; cl00999 290340010202 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 290340010203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340010205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010206 active site 290340010207 catalytic tetrad [active] 290340010208 DNA polymerase IV; Validated; Region: PRK03352 290340010209 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290340010210 active site 290340010211 DNA binding site [nucleotide binding] 290340010212 LysE type translocator; Region: LysE; cl00565 290340010213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340010214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010215 DNA binding site [nucleotide binding] 290340010216 domain linker motif; other site 290340010217 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010218 dimerization interface [polypeptide binding]; other site 290340010219 ligand binding site [chemical binding]; other site 290340010220 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290340010221 active site 290340010222 tetramer interface [polypeptide binding]; other site 290340010223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010224 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340010225 putative substrate translocation pore; other site 290340010226 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290340010227 substrate binding site [chemical binding]; other site 290340010228 dimer interface [polypeptide binding]; other site 290340010229 ATP binding site [chemical binding]; other site 290340010230 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340010231 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340010232 active site 290340010233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340010234 AAA domain; Region: AAA_18; pfam13238 290340010235 active site 290340010236 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 290340010237 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290340010238 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290340010239 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290340010240 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290340010241 putative active site [active] 290340010242 catalytic site [active] 290340010243 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290340010244 putative active site [active] 290340010245 catalytic site [active] 290340010246 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 290340010247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010248 catalytic residue [active] 290340010249 S-methylmethionine transporter; Provisional; Region: PRK11387 290340010250 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290340010251 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340010252 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340010253 dimer interface [polypeptide binding]; other site 290340010254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010255 catalytic residue [active] 290340010256 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290340010257 active sites [active] 290340010258 tetramer interface [polypeptide binding]; other site 290340010259 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010260 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010261 active site 290340010262 non-prolyl cis peptide bond; other site 290340010263 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290340010264 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340010265 Sulfate transporter family; Region: Sulfate_transp; cl15842 290340010266 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290340010267 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 290340010268 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340010269 active site residue [active] 290340010270 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 290340010271 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340010272 homodimer interface [polypeptide binding]; other site 290340010273 substrate-cofactor binding pocket; other site 290340010274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010275 catalytic residue [active] 290340010276 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 290340010277 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340010278 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290340010279 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 290340010280 putative active site [active] 290340010281 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340010282 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340010283 FAD binding pocket [chemical binding]; other site 290340010284 FAD binding motif [chemical binding]; other site 290340010285 phosphate binding motif [ion binding]; other site 290340010286 NAD binding pocket [chemical binding]; other site 290340010287 Penicillin amidase; Region: Penicil_amidase; pfam01804 290340010288 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 290340010289 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 290340010290 active site 290340010291 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290340010292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340010293 Cobalt transport protein; Region: CbiQ; cl00463 290340010294 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 290340010295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340010296 Walker A/P-loop; other site 290340010297 ATP binding site [chemical binding]; other site 290340010298 Q-loop/lid; other site 290340010299 ABC transporter signature motif; other site 290340010300 Walker B; other site 290340010301 D-loop; other site 290340010302 H-loop/switch region; other site 290340010303 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 290340010304 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 290340010305 Walker A/P-loop; other site 290340010306 ATP binding site [chemical binding]; other site 290340010307 Q-loop/lid; other site 290340010308 ABC transporter signature motif; other site 290340010309 Walker B; other site 290340010310 D-loop; other site 290340010311 H-loop/switch region; other site 290340010312 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 290340010313 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340010314 nudix motif; other site 290340010315 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 290340010316 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 290340010317 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 290340010318 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 290340010319 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 290340010320 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 290340010321 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 290340010322 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 290340010323 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 290340010324 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 290340010325 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 290340010326 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 290340010327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010328 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 290340010329 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 290340010330 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290340010331 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340010332 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010333 putative active site [active] 290340010334 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290340010335 trimer interface [polypeptide binding]; other site 290340010336 active site 290340010337 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 290340010338 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340010339 hydrophobic ligand binding site; other site 290340010340 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 290340010341 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340010342 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340010343 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290340010344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010345 NAD(P) binding pocket [chemical binding]; other site 290340010346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010347 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340010348 putative substrate translocation pore; other site 290340010349 Helix-turn-helix domains; Region: HTH; cl00088 290340010350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340010351 dimerization interface [polypeptide binding]; other site 290340010352 Predicted acetyltransferase [General function prediction only]; Region: COG3981 290340010353 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340010354 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340010355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340010356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010357 DNA binding site [nucleotide binding] 290340010358 domain linker motif; other site 290340010359 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290340010360 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010361 dimerization interface [polypeptide binding]; other site 290340010362 ligand binding site [chemical binding]; other site 290340010363 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290340010364 catalytic residue [active] 290340010365 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340010366 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 290340010367 Helix-turn-helix domains; Region: HTH; cl00088 290340010368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340010369 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290340010370 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 290340010371 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340010372 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 290340010373 N- and C-terminal domain interface [polypeptide binding]; other site 290340010374 D-xylulose kinase; Region: XylB; TIGR01312 290340010375 active site 290340010376 MgATP binding site [chemical binding]; other site 290340010377 catalytic site [active] 290340010378 metal binding site [ion binding]; metal-binding site 290340010379 carbohydrate binding site [chemical binding]; other site 290340010380 lac repressor; Reviewed; Region: lacI; PRK09526 290340010381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010382 DNA binding site [nucleotide binding] 290340010383 domain linker motif; other site 290340010384 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290340010385 ligand binding site [chemical binding]; other site 290340010386 dimerization interface (open form) [polypeptide binding]; other site 290340010387 dimerization interface (closed form) [polypeptide binding]; other site 290340010388 ribulokinase; Provisional; Region: PRK04123 290340010389 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 290340010390 putative N- and C-terminal domain interface [polypeptide binding]; other site 290340010391 putative active site [active] 290340010392 putative MgATP binding site [chemical binding]; other site 290340010393 catalytic site [active] 290340010394 metal binding site [ion binding]; metal-binding site 290340010395 carbohydrate binding site [chemical binding]; other site 290340010396 homodimer interface [polypeptide binding]; other site 290340010397 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 290340010398 intersubunit interface [polypeptide binding]; other site 290340010399 active site 290340010400 Zn2+ binding site [ion binding]; other site 290340010401 L-arabinose isomerase; Provisional; Region: PRK02929 290340010402 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 290340010403 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 290340010404 trimer interface [polypeptide binding]; other site 290340010405 putative substrate binding site [chemical binding]; other site 290340010406 putative metal binding site [ion binding]; other site 290340010407 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340010408 active site 290340010409 catalytic residues [active] 290340010410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340010411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010412 DNA binding site [nucleotide binding] 290340010413 domain linker motif; other site 290340010414 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010415 dimerization interface [polypeptide binding]; other site 290340010416 ligand binding site [chemical binding]; other site 290340010417 Domain of unknown function (DUF718); Region: DUF718; cl01281 290340010418 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 290340010419 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 290340010420 short chain dehydrogenase; Validated; Region: PRK08324 290340010421 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 290340010422 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290340010423 putative NAD(P) binding site [chemical binding]; other site 290340010424 active site 290340010425 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 290340010426 N- and C-terminal domain interface [polypeptide binding]; other site 290340010427 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 290340010428 active site 290340010429 catalytic site [active] 290340010430 metal binding site [ion binding]; metal-binding site 290340010431 ATP binding site [chemical binding]; other site 290340010432 carbohydrate binding site [chemical binding]; other site 290340010433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340010434 non-specific DNA binding site [nucleotide binding]; other site 290340010435 salt bridge; other site 290340010436 sequence-specific DNA binding site [nucleotide binding]; other site 290340010437 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290340010438 tetramerization interface [polypeptide binding]; other site 290340010439 active site 290340010440 Membrane transport protein; Region: Mem_trans; cl09117 290340010441 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340010442 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290340010443 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290340010444 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010445 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290340010446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340010447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340010448 substrate binding pocket [chemical binding]; other site 290340010449 membrane-bound complex binding site; other site 290340010450 hinge residues; other site 290340010451 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 290340010452 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290340010453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340010454 catalytic residue [active] 290340010455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010456 Coenzyme A binding pocket [chemical binding]; other site 290340010457 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340010458 Family description; Region: VCBS; pfam13517 290340010459 FG-GAP repeat; Region: FG-GAP; cl15299 290340010460 Family description; Region: VCBS; pfam13517 290340010461 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010462 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010463 active site 290340010464 non-prolyl cis peptide bond; other site 290340010465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010466 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 290340010467 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290340010468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340010470 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340010471 substrate binding pocket [chemical binding]; other site 290340010472 membrane-bound complex binding site; other site 290340010473 hinge residues; other site 290340010474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340010475 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290340010476 Walker A/P-loop; other site 290340010477 ATP binding site [chemical binding]; other site 290340010478 Q-loop/lid; other site 290340010479 ABC transporter signature motif; other site 290340010480 Walker B; other site 290340010481 D-loop; other site 290340010482 H-loop/switch region; other site 290340010483 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340010484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010485 dimer interface [polypeptide binding]; other site 290340010486 conserved gate region; other site 290340010487 putative PBP binding loops; other site 290340010488 ABC-ATPase subunit interface; other site 290340010489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010491 Coenzyme A binding pocket [chemical binding]; other site 290340010492 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 290340010493 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 290340010494 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010495 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340010496 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 290340010497 Copper resistance protein D; Region: CopD; cl00563 290340010498 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 290340010499 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290340010500 IHF dimer interface [polypeptide binding]; other site 290340010501 IHF - DNA interface [nucleotide binding]; other site 290340010502 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340010503 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340010504 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 290340010505 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 290340010506 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 290340010507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010508 Helix-turn-helix domains; Region: HTH; cl00088 290340010509 Bacterial transcriptional activator domain; Region: BTAD; smart01043 290340010510 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 290340010511 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 290340010512 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 290340010513 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340010514 active site 290340010515 catalytic triad [active] 290340010516 oxyanion hole [active] 290340010517 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340010518 Helix-turn-helix domains; Region: HTH; cl00088 290340010519 YCII-related domain; Region: YCII; cl00999 290340010520 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340010521 active site 290340010522 catalytic triad [active] 290340010523 oxyanion hole [active] 290340010524 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340010525 active site 290340010526 catalytic triad [active] 290340010527 oxyanion hole [active] 290340010528 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340010529 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340010530 FAD binding pocket [chemical binding]; other site 290340010531 FAD binding motif [chemical binding]; other site 290340010532 phosphate binding motif [ion binding]; other site 290340010533 NAD binding pocket [chemical binding]; other site 290340010534 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340010535 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340010536 Walker A/P-loop; other site 290340010537 ATP binding site [chemical binding]; other site 290340010538 Q-loop/lid; other site 290340010539 ABC transporter signature motif; other site 290340010540 Walker B; other site 290340010541 D-loop; other site 290340010542 H-loop/switch region; other site 290340010543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340010544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340010545 dimer interface [polypeptide binding]; other site 290340010546 putative PBP binding regions; other site 290340010547 ABC-ATPase subunit interface; other site 290340010548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340010549 dimer interface [polypeptide binding]; other site 290340010550 putative PBP binding regions; other site 290340010551 ABC-ATPase subunit interface; other site 290340010552 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340010553 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340010554 intersubunit interface [polypeptide binding]; other site 290340010555 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 290340010556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 290340010557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340010558 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290340010559 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 290340010560 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 290340010561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340010562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340010563 active site 290340010564 SEC-C motif; Region: SEC-C; pfam02810 290340010565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 290340010566 Flavin Reductases; Region: FlaRed; cl00801 290340010567 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 290340010568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010569 active site 290340010570 catalytic tetrad [active] 290340010571 sulfite oxidase; Provisional; Region: PLN00177 290340010572 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 290340010573 Moco binding site; other site 290340010574 metal coordination site [ion binding]; other site 290340010575 dimerization interface [polypeptide binding]; other site 290340010576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340010578 active site 290340010579 catalytic tetrad [active] 290340010580 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290340010581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010582 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340010583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010584 S-adenosylmethionine binding site [chemical binding]; other site 290340010585 PQQ-like domain; Region: PQQ_2; pfam13360 290340010586 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 290340010587 active site 290340010588 Trp docking motif [polypeptide binding]; other site 290340010589 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 290340010590 MatE; Region: MatE; cl10513 290340010591 Arginase family; Region: Arginase; cl00306 290340010592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340010593 RNA binding surface [nucleotide binding]; other site 290340010594 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 290340010595 transcriptional regulator NanR; Provisional; Region: PRK03837 290340010596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010597 DNA-binding site [nucleotide binding]; DNA binding site 290340010598 FCD domain; Region: FCD; cl11656 290340010599 L-asparaginase II; Region: Asparaginase_II; cl01842 290340010600 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290340010601 Aspartase; Region: Aspartase; cd01357 290340010602 active sites [active] 290340010603 tetramer interface [polypeptide binding]; other site 290340010604 L-asparagine permease; Provisional; Region: PRK15049 290340010605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340010606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010607 DNA-binding site [nucleotide binding]; DNA binding site 290340010608 FCD domain; Region: FCD; cl11656 290340010609 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 290340010610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340010611 active site 290340010612 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340010613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010614 active site 290340010615 catalytic tetrad [active] 290340010616 Domain of unknown function (DUF718); Region: DUF718; cl01281 290340010617 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 290340010618 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 290340010619 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340010620 putative active site pocket [active] 290340010621 metal binding site [ion binding]; metal-binding site 290340010622 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340010623 classical (c) SDRs; Region: SDR_c; cd05233 290340010624 NAD(P) binding site [chemical binding]; other site 290340010625 active site 290340010626 Family description; Region: VCBS; pfam13517 290340010627 FG-GAP repeat; Region: FG-GAP; cl15299 290340010628 Family description; Region: VCBS; pfam13517 290340010629 Family description; Region: VCBS; pfam13517 290340010630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010631 Coenzyme A binding pocket [chemical binding]; other site 290340010632 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340010633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340010634 Walker A motif; other site 290340010635 ATP binding site [chemical binding]; other site 290340010636 Walker B motif; other site 290340010637 arginine finger; other site 290340010638 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 290340010639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290340010640 Helix-turn-helix domains; Region: HTH; cl00088 290340010641 WHG domain; Region: WHG; pfam13305 290340010642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340010643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340010644 active site 290340010645 HIGH motif; other site 290340010646 nucleotide binding site [chemical binding]; other site 290340010647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340010648 active site 290340010649 KMSKS motif; other site 290340010650 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340010651 Helix-turn-helix domains; Region: HTH; cl00088 290340010652 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340010653 Helix-turn-helix domains; Region: HTH; cl00088 290340010654 LysE type translocator; Region: LysE; cl00565 290340010655 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 290340010656 putative hydrophobic ligand binding site [chemical binding]; other site 290340010657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340010658 dimerization interface [polypeptide binding]; other site 290340010659 putative DNA binding site [nucleotide binding]; other site 290340010660 putative Zn2+ binding site [ion binding]; other site 290340010661 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290340010662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010663 Helix-turn-helix domains; Region: HTH; cl00088 290340010664 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010665 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290340010666 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290340010667 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 290340010668 active site 290340010669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010670 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010671 putative substrate translocation pore; other site 290340010672 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340010673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010674 DNA-binding site [nucleotide binding]; DNA binding site 290340010675 FCD domain; Region: FCD; cl11656 290340010676 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340010677 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340010678 dimer interface [polypeptide binding]; other site 290340010679 active site 290340010680 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340010681 folate binding site [chemical binding]; other site 290340010682 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 290340010683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010684 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 290340010685 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 290340010686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290340010687 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340010688 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 290340010689 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340010690 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340010691 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 290340010692 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340010693 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340010694 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340010695 putative active site [active] 290340010696 putative substrate binding site [chemical binding]; other site 290340010697 putative cosubstrate binding site; other site 290340010698 catalytic site [active] 290340010699 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340010700 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340010701 Helix-turn-helix domains; Region: HTH; cl00088 290340010702 Sodium:solute symporter family; Region: SSF; cl00456 290340010703 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 290340010704 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 290340010705 active site 290340010706 catalytic site [active] 290340010707 Zn binding site [ion binding]; other site 290340010708 tetramer interface [polypeptide binding]; other site 290340010709 Protein of unknown function (DUF456); Region: DUF456; cl01069 290340010710 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290340010711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010712 NAD(P) binding pocket [chemical binding]; other site 290340010713 FG-GAP repeat; Region: FG-GAP; cl15299 290340010714 Family description; Region: VCBS; pfam13517 290340010715 FG-GAP repeat; Region: FG-GAP; cl15299 290340010716 Family description; Region: VCBS; pfam13517 290340010717 Family description; Region: VCBS; pfam13517 290340010718 FG-GAP repeat; Region: FG-GAP; cl15299 290340010719 Family description; Region: VCBS; pfam13517 290340010720 Family description; Region: VCBS; pfam13517 290340010721 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 290340010722 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340010723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340010725 putative substrate translocation pore; other site 290340010726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010727 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 290340010728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010729 putative substrate translocation pore; other site 290340010730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340010733 Helix-turn-helix domains; Region: HTH; cl00088 290340010734 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340010735 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340010736 Helix-turn-helix domains; Region: HTH; cl00088 290340010737 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 290340010738 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290340010739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340010740 Walker A/P-loop; other site 290340010741 ATP binding site [chemical binding]; other site 290340010742 Q-loop/lid; other site 290340010743 ABC transporter signature motif; other site 290340010744 Walker B; other site 290340010745 D-loop; other site 290340010746 H-loop/switch region; other site 290340010747 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340010748 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290340010749 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 290340010750 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340010751 Walker A/P-loop; other site 290340010752 ATP binding site [chemical binding]; other site 290340010753 Q-loop/lid; other site 290340010754 ABC transporter signature motif; other site 290340010755 Walker B; other site 290340010756 D-loop; other site 290340010757 H-loop/switch region; other site 290340010758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340010759 ABC-ATPase subunit interface; other site 290340010760 dimer interface [polypeptide binding]; other site 290340010761 putative PBP binding regions; other site 290340010762 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340010763 ABC-ATPase subunit interface; other site 290340010764 dimer interface [polypeptide binding]; other site 290340010765 putative PBP binding regions; other site 290340010766 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 290340010767 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340010768 putative ligand binding residues [chemical binding]; other site 290340010769 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 290340010770 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290340010771 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290340010772 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 290340010773 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 290340010774 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290340010775 active site 290340010776 P-loop; other site 290340010777 phosphorylation site [posttranslational modification] 290340010778 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340010779 active site 290340010780 phosphorylation site [posttranslational modification] 290340010781 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290340010782 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290340010783 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340010784 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340010785 dimerization domain swap beta strand [polypeptide binding]; other site 290340010786 regulatory protein interface [polypeptide binding]; other site 290340010787 active site 290340010788 regulatory phosphorylation site [posttranslational modification]; other site 290340010789 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340010790 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 290340010791 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 290340010792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010793 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 290340010794 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340010795 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 290340010796 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 290340010797 active site 290340010798 DNA binding site [nucleotide binding] 290340010799 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 290340010800 DNA binding site [nucleotide binding] 290340010801 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340010802 Helix-turn-helix domains; Region: HTH; cl00088 290340010803 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340010804 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290340010805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340010807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340010809 DNA binding residues [nucleotide binding] 290340010810 putative oxidoreductase; Provisional; Region: PRK11579 290340010811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340010813 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 290340010814 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340010815 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 290340010816 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340010817 Walker A/P-loop; other site 290340010818 ATP binding site [chemical binding]; other site 290340010819 Q-loop/lid; other site 290340010820 ABC transporter signature motif; other site 290340010821 Walker B; other site 290340010822 D-loop; other site 290340010823 H-loop/switch region; other site 290340010824 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340010825 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290340010826 Walker A/P-loop; other site 290340010827 ATP binding site [chemical binding]; other site 290340010828 Q-loop/lid; other site 290340010829 ABC transporter signature motif; other site 290340010830 Walker B; other site 290340010831 D-loop; other site 290340010832 H-loop/switch region; other site 290340010833 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340010834 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290340010835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010836 dimer interface [polypeptide binding]; other site 290340010837 conserved gate region; other site 290340010838 putative PBP binding loops; other site 290340010839 ABC-ATPase subunit interface; other site 290340010840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340010841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010842 dimer interface [polypeptide binding]; other site 290340010843 conserved gate region; other site 290340010844 putative PBP binding loops; other site 290340010845 ABC-ATPase subunit interface; other site 290340010846 Helix-turn-helix domains; Region: HTH; cl00088 290340010847 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340010848 Sporulation and spore germination; Region: Germane; cl11253 290340010849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340010850 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340010851 tetramer interface [polypeptide binding]; other site 290340010852 active site 290340010853 Mg2+/Mn2+ binding site [ion binding]; other site 290340010854 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290340010855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340010856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010857 homodimer interface [polypeptide binding]; other site 290340010858 catalytic residue [active] 290340010859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340010860 Ligand Binding Site [chemical binding]; other site 290340010861 Spore germination protein; Region: Spore_permease; cl15802 290340010862 Amino acid permease; Region: AA_permease_2; pfam13520 290340010863 Spore germination protein; Region: Spore_permease; cl15802 290340010864 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340010865 Amidohydrolase; Region: Amidohydro_4; pfam13147 290340010866 active site 290340010867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340010868 E3 interaction surface; other site 290340010869 lipoyl attachment site [posttranslational modification]; other site 290340010870 e3 binding domain; Region: E3_binding; pfam02817 290340010871 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340010872 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 290340010873 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340010874 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340010875 alpha subunit interface [polypeptide binding]; other site 290340010876 TPP binding site [chemical binding]; other site 290340010877 heterodimer interface [polypeptide binding]; other site 290340010878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340010879 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340010880 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340010881 tetramer interface [polypeptide binding]; other site 290340010882 TPP-binding site [chemical binding]; other site 290340010883 heterodimer interface [polypeptide binding]; other site 290340010884 phosphorylation loop region [posttranslational modification] 290340010885 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 290340010886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340010887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010888 homodimer interface [polypeptide binding]; other site 290340010889 catalytic residue [active] 290340010890 Membrane protein of unknown function; Region: DUF360; cl00850 290340010891 adenylosuccinate lyase; Provisional; Region: PRK09285 290340010892 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 290340010893 tetramer interface [polypeptide binding]; other site 290340010894 active site 290340010895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340010896 catalytic core [active] 290340010897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010898 Coenzyme A binding pocket [chemical binding]; other site 290340010899 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340010900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010901 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010902 putative substrate translocation pore; other site 290340010903 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 290340010904 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290340010905 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290340010906 LamB/YcsF family; Region: LamB_YcsF; cl00664 290340010907 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 290340010908 Helix-turn-helix domains; Region: HTH; cl00088 290340010909 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 290340010910 putative dimerization interface [polypeptide binding]; other site 290340010911 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340010912 aspartate aminotransferase; Provisional; Region: PRK05764 290340010913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340010914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010915 homodimer interface [polypeptide binding]; other site 290340010916 catalytic residue [active] 290340010917 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340010918 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 290340010919 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340010920 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340010921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340010922 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 290340010923 NAD binding site [chemical binding]; other site 290340010924 catalytic residues [active] 290340010925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010926 DNA-binding site [nucleotide binding]; DNA binding site 290340010927 FCD domain; Region: FCD; cl11656 290340010928 hypothetical protein; Provisional; Region: PRK12764 290340010929 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340010930 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340010931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 290340010932 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340010933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010934 CsbD-like; Region: CsbD; cl15799 290340010935 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340010936 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 290340010937 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 290340010938 Isochorismatase family; Region: Isochorismatase; pfam00857 290340010939 catalytic triad [active] 290340010940 conserved cis-peptide bond; other site 290340010941 short chain dehydrogenase; Provisional; Region: PRK06701 290340010942 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290340010943 NAD binding site [chemical binding]; other site 290340010944 metal binding site [ion binding]; metal-binding site 290340010945 active site 290340010946 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340010947 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340010948 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340010949 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 290340010950 Asp23 family; Region: Asp23; cl00574 290340010951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010952 RNA polymerase sigma factor; Reviewed; Region: PRK12527 290340010953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340010954 DNA binding residues [nucleotide binding] 290340010955 Asp23 family; Region: Asp23; cl00574 290340010956 Helix-turn-helix domains; Region: HTH; cl00088 290340010957 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010958 dimerization interface [polypeptide binding]; other site 290340010959 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340010960 ligand binding site [chemical binding]; other site 290340010961 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340010962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340010963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010964 dimer interface [polypeptide binding]; other site 290340010965 conserved gate region; other site 290340010966 putative PBP binding loops; other site 290340010967 ABC-ATPase subunit interface; other site 290340010968 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340010969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010970 dimer interface [polypeptide binding]; other site 290340010971 conserved gate region; other site 290340010972 putative PBP binding loops; other site 290340010973 ABC-ATPase subunit interface; other site 290340010974 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340010975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010976 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340010977 GAF domain; Region: GAF_2; pfam13185 290340010978 GAF domain; Region: GAF; cl15785 290340010979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340010980 dimer interface [polypeptide binding]; other site 290340010981 phosphorylation site [posttranslational modification] 290340010982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340010983 ATP binding site [chemical binding]; other site 290340010984 Mg2+ binding site [ion binding]; other site 290340010985 G-X-G motif; other site 290340010986 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 290340010987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340010988 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340010989 active site 290340010990 ATP binding site [chemical binding]; other site 290340010991 substrate binding site [chemical binding]; other site 290340010992 activation loop (A-loop); other site 290340010993 Sodium:solute symporter family; Region: SSF; cl00456 290340010994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340010995 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340010996 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340010997 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340010998 active site 290340010999 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340011001 catalytic core [active] 290340011002 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340011003 Spore germination protein; Region: Spore_permease; cl15802 290340011004 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290340011005 NmrA-like family; Region: NmrA; pfam05368 290340011006 NAD(P) binding site [chemical binding]; other site 290340011007 putative active site [active] 290340011008 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340011009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340011010 non-specific DNA binding site [nucleotide binding]; other site 290340011011 salt bridge; other site 290340011012 sequence-specific DNA binding site [nucleotide binding]; other site 290340011013 Cupin domain; Region: Cupin_2; cl09118 290340011014 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 290340011015 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340011016 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340011017 inhibitor site; inhibition site 290340011018 active site 290340011019 dimer interface [polypeptide binding]; other site 290340011020 catalytic residue [active] 290340011021 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 290340011022 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 290340011023 putative NAD(P) binding site [chemical binding]; other site 290340011024 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290340011025 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290340011026 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 290340011027 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 290340011028 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 290340011029 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 290340011030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011031 catalytic residue [active] 290340011032 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 290340011033 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 290340011034 putative active site [active] 290340011035 putative dimer interface [polypeptide binding]; other site 290340011036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011037 putative substrate translocation pore; other site 290340011038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340011040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340011041 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340011042 active site 290340011043 metal binding site [ion binding]; metal-binding site 290340011044 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340011045 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340011046 DNA binding residues [nucleotide binding] 290340011047 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340011048 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340011049 active site 290340011050 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 290340011051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011053 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011054 Helix-turn-helix domains; Region: HTH; cl00088 290340011055 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011056 benzoate transport; Region: 2A0115; TIGR00895 290340011057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011058 putative substrate translocation pore; other site 290340011059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011060 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290340011061 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340011062 Catalytic site [active] 290340011063 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290340011064 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340011065 Short C-terminal domain; Region: SHOCT; cl01373 290340011066 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290340011067 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 290340011068 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290340011069 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340011070 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290340011071 putative active site [active] 290340011072 catalytic site [active] 290340011073 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290340011074 putative active site [active] 290340011075 catalytic site [active] 290340011076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340011077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340011078 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 290340011079 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 290340011080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011081 DNA binding residues [nucleotide binding] 290340011082 dimerization interface [polypeptide binding]; other site 290340011083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340011084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340011085 active site 290340011086 ATP binding site [chemical binding]; other site 290340011087 substrate binding site [chemical binding]; other site 290340011088 activation loop (A-loop); other site 290340011089 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340011090 Helix-turn-helix domains; Region: HTH; cl00088 290340011091 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 290340011092 lipoyl synthase; Provisional; Region: PRK05481 290340011093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340011094 FeS/SAM binding site; other site 290340011095 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340011096 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340011097 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 290340011098 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340011099 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340011100 dimer interface [polypeptide binding]; other site 290340011101 active site 290340011102 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340011103 folate binding site [chemical binding]; other site 290340011104 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340011105 lipoyl attachment site [posttranslational modification]; other site 290340011106 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290340011107 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340011108 glycine dehydrogenase; Provisional; Region: PRK05367 290340011109 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340011110 tetramer interface [polypeptide binding]; other site 290340011111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011112 catalytic residue [active] 290340011113 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340011114 tetramer interface [polypeptide binding]; other site 290340011115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011116 catalytic residue [active] 290340011117 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340011118 Helix-turn-helix domains; Region: HTH; cl00088 290340011119 Arginase family; Region: Arginase; cl00306 290340011120 Sodium:solute symporter family; Region: SSF; cl00456 290340011121 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340011122 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340011123 tetrameric interface [polypeptide binding]; other site 290340011124 NAD binding site [chemical binding]; other site 290340011125 catalytic residues [active] 290340011126 substrate binding site [chemical binding]; other site 290340011127 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 290340011128 FAD binding domain; Region: FAD_binding_4; pfam01565 290340011129 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 290340011130 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 290340011131 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290340011132 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290340011133 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290340011134 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 290340011135 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340011136 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290340011137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340011138 motif II; other site 290340011139 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 290340011140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011141 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340011142 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340011143 PaaX-like protein; Region: PaaX; pfam07848 290340011144 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 290340011145 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340011146 active site 290340011147 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290340011148 AMP-binding enzyme; Region: AMP-binding; cl15778 290340011149 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340011150 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 290340011151 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290340011152 active site 290340011153 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290340011154 catalytic triad [active] 290340011155 dimer interface [polypeptide binding]; other site 290340011156 Cupin domain; Region: Cupin_2; cl09118 290340011157 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340011158 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340011159 homotrimer interaction site [polypeptide binding]; other site 290340011160 putative active site [active] 290340011161 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340011162 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290340011163 Helix-turn-helix domains; Region: HTH; cl00088 290340011164 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011165 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340011166 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340011167 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 290340011168 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340011169 dimer interface [polypeptide binding]; other site 290340011170 active site 290340011171 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290340011172 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 290340011173 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 290340011174 tetramer interface [polypeptide binding]; other site 290340011175 active site 290340011176 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 290340011177 heterodimer interface [polypeptide binding]; other site 290340011178 active site 290340011179 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340011180 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 290340011181 active site 290340011182 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340011183 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340011184 DNA interaction; other site 290340011185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 290340011186 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 290340011187 dimer interface [polypeptide binding]; other site 290340011188 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 290340011189 active site 290340011190 Fe binding site [ion binding]; other site 290340011191 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 290340011192 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340011193 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340011194 shikimate binding site; other site 290340011195 NAD(P) binding site [chemical binding]; other site 290340011196 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011197 Helix-turn-helix domains; Region: HTH; cl00088 290340011198 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011200 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011201 putative substrate translocation pore; other site 290340011202 Family description; Region: VCBS; pfam13517 290340011203 FG-GAP repeat; Region: FG-GAP; cl15299 290340011204 Family description; Region: VCBS; pfam13517 290340011205 Family description; Region: VCBS; pfam13517 290340011206 Family description; Region: VCBS; pfam13517 290340011207 FG-GAP repeat; Region: FG-GAP; cl15299 290340011208 Family description; Region: VCBS; pfam13517 290340011209 FG-GAP repeat; Region: FG-GAP; cl15299 290340011210 Family description; Region: VCBS; pfam13517 290340011211 FG-GAP repeat; Region: FG-GAP; cl15299 290340011212 Family description; Region: VCBS; pfam13517 290340011213 Ubiquitin-like proteins; Region: UBQ; cl00155 290340011214 charged pocket; other site 290340011215 hydrophobic patch; other site 290340011216 VPS10 domain; Region: VPS10; smart00602 290340011217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340011218 metal binding site [ion binding]; metal-binding site 290340011219 active site 290340011220 I-site; other site 290340011221 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340011222 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340011223 tetramer interface [polypeptide binding]; other site 290340011224 active site 290340011225 Mg2+/Mn2+ binding site [ion binding]; other site 290340011226 Helix-turn-helix domains; Region: HTH; cl00088 290340011227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340011228 dimerization interface [polypeptide binding]; other site 290340011229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340011230 Ligand Binding Site [chemical binding]; other site 290340011231 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 290340011232 GntP family permease; Region: GntP_permease; pfam02447 290340011233 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290340011234 active site 290340011235 intersubunit interface [polypeptide binding]; other site 290340011236 catalytic residue [active] 290340011237 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 290340011238 Amidohydrolase family; Region: Amidohydro_3; pfam07969 290340011239 active site 290340011240 putative substrate binding pocket [chemical binding]; other site 290340011241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340011242 active site 290340011243 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 290340011244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 290340011245 dimer interface [polypeptide binding]; other site 290340011246 active site 290340011247 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340011248 substrate binding site [chemical binding]; other site 290340011249 catalytic residue [active] 290340011250 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340011251 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290340011252 substrate binding site [chemical binding]; other site 290340011253 ATP binding site [chemical binding]; other site 290340011254 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011255 Helix-turn-helix domains; Region: HTH; cl00088 290340011256 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011257 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340011258 homotrimer interaction site [polypeptide binding]; other site 290340011259 putative active site [active] 290340011260 Membrane transport protein; Region: Mem_trans; cl09117 290340011261 LssY C-terminus; Region: LssY_C; pfam14067 290340011262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011263 NAD(P) binding site [chemical binding]; other site 290340011264 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340011265 active site 290340011266 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 290340011267 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290340011268 active site 290340011269 catalytic site [active] 290340011270 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 290340011271 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340011272 putative peptidoglycan binding site; other site 290340011273 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 290340011274 Predicted acetyltransferase [General function prediction only]; Region: COG3981 290340011275 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340011276 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290340011277 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290340011278 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290340011279 putative active site [active] 290340011280 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 290340011281 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340011282 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340011283 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340011284 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290340011285 putative active site [active] 290340011286 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340011287 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340011288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340011289 DNA binding site [nucleotide binding] 290340011290 domain linker motif; other site 290340011291 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 290340011292 putative dimerization interface [polypeptide binding]; other site 290340011293 putative ligand binding site [chemical binding]; other site 290340011294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340011295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011296 dimer interface [polypeptide binding]; other site 290340011297 conserved gate region; other site 290340011298 putative PBP binding loops; other site 290340011299 ABC-ATPase subunit interface; other site 290340011300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340011301 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340011302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340011303 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340011304 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340011305 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 290340011306 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340011307 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340011308 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 290340011309 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290340011310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011311 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340011312 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340011313 active site residue [active] 290340011314 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011315 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011316 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 290340011317 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 290340011318 active site 290340011319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340011320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011321 dimer interface [polypeptide binding]; other site 290340011322 conserved gate region; other site 290340011323 putative PBP binding loops; other site 290340011324 ABC-ATPase subunit interface; other site 290340011325 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340011326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011327 dimer interface [polypeptide binding]; other site 290340011328 conserved gate region; other site 290340011329 putative PBP binding loops; other site 290340011330 ABC-ATPase subunit interface; other site 290340011331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340011332 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340011333 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340011334 putative homodimer interface [polypeptide binding]; other site 290340011335 putative homotetramer interface [polypeptide binding]; other site 290340011336 putative allosteric switch controlling residues; other site 290340011337 putative metal binding site [ion binding]; other site 290340011338 putative homodimer-homodimer interface [polypeptide binding]; other site 290340011339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340011340 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340011341 metal-binding site [ion binding] 290340011342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340011343 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340011344 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 290340011345 EamA-like transporter family; Region: EamA; cl01037 290340011346 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290340011347 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 290340011348 putative efflux protein, MATE family; Region: matE; TIGR00797 290340011349 MatE; Region: MatE; cl10513 290340011350 MatE; Region: MatE; cl10513 290340011351 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 290340011352 DoxX; Region: DoxX; cl00976 290340011353 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290340011354 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340011355 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340011356 AAA domain; Region: AAA_22; pfam13401 290340011357 Predicted ATPase [General function prediction only]; Region: COG3899 290340011358 Predicted DNA binding protein [General function prediction only]; Region: COG3413 290340011359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011360 DNA binding residues [nucleotide binding] 290340011361 dimerization interface [polypeptide binding]; other site 290340011362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011363 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340011364 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340011365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011366 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 290340011367 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 290340011368 NADP binding site [chemical binding]; other site 290340011369 active site 290340011370 putative substrate binding site [chemical binding]; other site 290340011371 GDP-mannose 4,6-dehydratase; Region: PLN02653 290340011372 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 290340011373 NADP-binding site; other site 290340011374 homotetramer interface [polypeptide binding]; other site 290340011375 substrate binding site [chemical binding]; other site 290340011376 homodimer interface [polypeptide binding]; other site 290340011377 active site 290340011378 putative glycosyl transferase; Provisional; Region: PRK10307 290340011379 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 290340011380 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 290340011381 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 290340011382 putative trimer interface [polypeptide binding]; other site 290340011383 putative active site [active] 290340011384 putative substrate binding site [chemical binding]; other site 290340011385 putative CoA binding site [chemical binding]; other site 290340011386 O-Antigen ligase; Region: Wzy_C; cl04850 290340011387 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290340011388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340011389 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290340011390 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 290340011391 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 290340011392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340011393 putative ADP-binding pocket [chemical binding]; other site 290340011394 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 290340011395 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290340011396 Chain length determinant protein; Region: Wzz; cl15801 290340011397 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290340011398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011399 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340011400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011401 Bacterial sugar transferase; Region: Bac_transf; cl00939 290340011402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011403 Walker A motif; other site 290340011404 ATP binding site [chemical binding]; other site 290340011405 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340011406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011407 DNA-binding site [nucleotide binding]; DNA binding site 290340011408 FCD domain; Region: FCD; cl11656 290340011409 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340011410 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340011411 PYR/PP interface [polypeptide binding]; other site 290340011412 dimer interface [polypeptide binding]; other site 290340011413 TPP binding site [chemical binding]; other site 290340011414 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340011415 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340011416 TPP-binding site [chemical binding]; other site 290340011417 dimer interface [polypeptide binding]; other site 290340011418 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011420 putative substrate translocation pore; other site 290340011421 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340011422 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340011423 Metal-binding active site; metal-binding site 290340011424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011425 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340011426 NAD(P) binding site [chemical binding]; other site 290340011427 active site 290340011428 dihydroxyacetone kinase; Provisional; Region: PRK14479 290340011429 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290340011430 DAK2 domain; Region: Dak2; cl03685 290340011431 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 290340011432 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 290340011433 replicative DNA helicase; Region: DnaB; TIGR00665 290340011434 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290340011435 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290340011436 Walker A motif; other site 290340011437 ATP binding site [chemical binding]; other site 290340011438 Walker B motif; other site 290340011439 DNA binding loops [nucleotide binding] 290340011440 hypothetical protein; Provisional; Region: PRK06771 290340011441 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 290340011442 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340011443 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290340011444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340011445 substrate binding pocket [chemical binding]; other site 290340011446 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 290340011447 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 290340011448 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340011449 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340011450 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 290340011451 active site 290340011452 catalytic residues [active] 290340011453 metal binding site [ion binding]; metal-binding site 290340011454 glyoxylate reductase; Reviewed; Region: PRK13243 290340011455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011456 Glycerate kinase family; Region: Gly_kinase; cl00841 290340011457 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290340011458 hydrophobic ligand binding site; other site 290340011459 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 290340011460 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340011461 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340011462 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 290340011463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340011464 S-adenosylmethionine binding site [chemical binding]; other site 290340011465 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011466 Helix-turn-helix domains; Region: HTH; cl00088 290340011467 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011468 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340011469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011470 Walker A/P-loop; other site 290340011471 ATP binding site [chemical binding]; other site 290340011472 Q-loop/lid; other site 290340011473 Walker B; other site 290340011474 D-loop; other site 290340011475 H-loop/switch region; other site 290340011476 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 290340011477 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 290340011478 Protein of unknown function (DUF419); Region: DUF419; cl15265 290340011479 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290340011480 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290340011481 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290340011482 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 290340011483 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340011484 dimer interface [polypeptide binding]; other site 290340011485 ssDNA binding site [nucleotide binding]; other site 290340011486 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340011487 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 290340011488 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 290340011489 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290340011490 Spore germination protein; Region: Spore_permease; cl15802 290340011491 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 290340011492 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 290340011493 active site 290340011494 metal binding site [ion binding]; metal-binding site 290340011495 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 290340011496 putative active site [active] 290340011497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340011499 active site 290340011500 phosphorylation site [posttranslational modification] 290340011501 intermolecular recognition site; other site 290340011502 dimerization interface [polypeptide binding]; other site 290340011503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011504 DNA binding residues [nucleotide binding] 290340011505 dimerization interface [polypeptide binding]; other site 290340011506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340011507 Histidine kinase; Region: HisKA_3; pfam07730 290340011508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290340011509 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 290340011510 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290340011511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340011512 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 290340011513 Walker A/P-loop; other site 290340011514 ATP binding site [chemical binding]; other site 290340011515 Q-loop/lid; other site 290340011516 ABC transporter signature motif; other site 290340011517 Walker B; other site 290340011518 D-loop; other site 290340011519 H-loop/switch region; other site 290340011520 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290340011521 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340011522 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290340011523 active site 290340011524 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340011525 Helix-turn-helix domains; Region: HTH; cl00088 290340011526 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290340011527 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340011528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011529 Walker A/P-loop; other site 290340011530 ATP binding site [chemical binding]; other site 290340011531 Q-loop/lid; other site 290340011532 ABC transporter signature motif; other site 290340011533 Walker B; other site 290340011534 D-loop; other site 290340011535 H-loop/switch region; other site 290340011536 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290340011537 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340011538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340011539 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 290340011540 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 290340011541 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290340011542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290340011543 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 290340011544 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290340011545 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 290340011546 putative active site [active] 290340011547 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 290340011548 putative catalytic site [active] 290340011549 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340011550 NPCBM/NEW2 domain; Region: NPCBM; cl07060 290340011551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340011553 active site 290340011554 phosphorylation site [posttranslational modification] 290340011555 intermolecular recognition site; other site 290340011556 dimerization interface [polypeptide binding]; other site 290340011557 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011558 DNA binding residues [nucleotide binding] 290340011559 dimerization interface [polypeptide binding]; other site 290340011560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340011561 Histidine kinase; Region: HisKA_3; pfam07730 290340011562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290340011563 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340011564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340011565 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290340011566 Walker A/P-loop; other site 290340011567 ATP binding site [chemical binding]; other site 290340011568 Q-loop/lid; other site 290340011569 ABC transporter signature motif; other site 290340011570 Walker B; other site 290340011571 D-loop; other site 290340011572 H-loop/switch region; other site 290340011573 Helix-turn-helix domains; Region: HTH; cl00088 290340011574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011575 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290340011576 NAD(P) binding site [chemical binding]; other site 290340011577 active site 290340011578 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290340011579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011580 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 290340011581 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340011582 catalytic core [active] 290340011583 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290340011584 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 290340011585 active site 290340011586 NTP binding site [chemical binding]; other site 290340011587 metal binding triad [ion binding]; metal-binding site 290340011588 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290340011589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290340011590 Zn2+ binding site [ion binding]; other site 290340011591 Mg2+ binding site [ion binding]; other site 290340011592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290340011593 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290340011594 active site 290340011595 Ap6A binding site [chemical binding]; other site 290340011596 nudix motif; other site 290340011597 metal binding site [ion binding]; metal-binding site 290340011598 integral membrane protein MviN; Region: mviN; TIGR01695 290340011599 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340011600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340011602 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 290340011603 ParB-like nuclease domain; Region: ParBc; cl02129 290340011604 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340011605 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340011606 P-loop; other site 290340011607 Magnesium ion binding site [ion binding]; other site 290340011608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340011609 Magnesium ion binding site [ion binding]; other site 290340011610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290340011611 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 290340011612 G-X-X-G motif; other site 290340011613 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 290340011614 RxxxH motif; other site 290340011615 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 290340011616 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 290340011617 Haemolytic domain; Region: Haemolytic; cl00506 290340011618 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 290340011619 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340011620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340011621 Magnesium ion binding site [ion binding]; other site 290340011622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011623 Helix-turn-helix domains; Region: HTH; cl00088 290340011624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011625 dimerization interface [polypeptide binding]; other site 290340011626 putative DNA binding site [nucleotide binding]; other site 290340011627 putative Zn2+ binding site [ion binding]; other site 290340011628 SAF domain; Region: SAF; cl00555 290340011629 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290340011630 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 290340011631 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340011632 ATP binding site [chemical binding]; other site 290340011633 Walker A motif; other site 290340011634 hexamer interface [polypeptide binding]; other site 290340011635 Walker B motif; other site 290340011636 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340011637 putative peptidoglycan binding site; other site 290340011638 AAA-like domain; Region: AAA_10; pfam12846 290340011639 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340011640 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340011641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340011642 active site 290340011643 Int/Topo IB signature motif; other site 290340011644 DNA binding site [nucleotide binding] 290340011645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340011646 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 290340011647 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340011648 active site 290340011649 DNA binding site [nucleotide binding] 290340011650 Int/Topo IB signature motif; other site 290340011651 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340011652 putative catalytic site [active] 290340011653 putative metal binding site [ion binding]; other site 290340011654 putative phosphate binding site [ion binding]; other site 290340011655 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340011656 putative catalytic site [active] 290340011657 putative metal binding site [ion binding]; other site 290340011658 putative phosphate binding site [ion binding]; other site 290340011659 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 290340011660 AAA domain; Region: AAA_22; pfam13401 290340011661 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 290340011662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011663 Walker A motif; other site 290340011664 ATP binding site [chemical binding]; other site 290340011665 Walker B motif; other site 290340011666 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290340011667 DnaA box-binding interface [nucleotide binding]; other site 290340011668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340011669 active site 290340011670 DNA binding site [nucleotide binding] 290340011671 Int/Topo IB signature motif; other site 290340011672 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340011673 active site 290340011674 Int/Topo IB signature motif; other site 290340011675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290340011676 Creatinine amidohydrolase; Region: Creatininase; cl00618 290340011677 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 290340011678 transposase; Provisional; Region: PRK06526 290340011679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340011680 Walker A motif; other site 290340011681 ATP binding site [chemical binding]; other site 290340011682 Walker B motif; other site 290340011683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290340011684 Helix-turn-helix domains; Region: HTH; cl00088 290340011685 Integrase core domain; Region: rve; cl01316 290340011686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290340011687 Epoxide hydrolase N terminus; Region: EHN; pfam06441 290340011688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011689 Cupin domain; Region: Cupin_2; cl09118 290340011690 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340011691 Spore germination protein; Region: Spore_permease; cl15802 290340011692 Ferredoxin [Energy production and conversion]; Region: COG1146 290340011693 4Fe-4S binding domain; Region: Fer4; cl02805 290340011694 ferredoxin-NADP+ reductase; Region: PLN02852 290340011695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011696 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 290340011697 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340011698 NAD binding site [chemical binding]; other site 290340011699 catalytic Zn binding site [ion binding]; other site 290340011700 substrate binding site [chemical binding]; other site 290340011701 structural Zn binding site [ion binding]; other site 290340011702 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340011703 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 290340011704 AMP-binding enzyme; Region: AMP-binding; cl15778 290340011705 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 290340011706 NAD(P) binding site [chemical binding]; other site 290340011707 catalytic residues [active] 290340011708 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290340011709 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340011710 catalytic triad [active] 290340011711 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340011712 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340011713 NAD(P) binding site [chemical binding]; other site 290340011714 catalytic residues [active] 290340011715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340011716 classical (c) SDRs; Region: SDR_c; cd05233 290340011717 NAD(P) binding site [chemical binding]; other site 290340011718 active site 290340011719 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340011720 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340011721 catalytic triad [active] 290340011722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 290340011723 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 290340011724 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 290340011725 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290340011726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011727 NAD(P) binding site [chemical binding]; other site 290340011728 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340011729 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340011730 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340011731 GAF domain; Region: GAF_2; pfam13185 290340011732 GAF domain; Region: GAF; cl15785 290340011733 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340011734 Helix-turn-helix domains; Region: HTH; cl00088 290340011735 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340011736 Helix-turn-helix domains; Region: HTH; cl00088 290340011737 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340011738 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290340011739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011740 pyruvate carboxylase; Reviewed; Region: PRK12999 290340011741 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340011742 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290340011743 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290340011744 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290340011745 active site 290340011746 catalytic residues [active] 290340011747 metal binding site [ion binding]; metal-binding site 290340011748 homodimer binding site [polypeptide binding]; other site 290340011749 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340011750 carboxyltransferase (CT) interaction site; other site 290340011751 biotinylation site [posttranslational modification]; other site 290340011752 Transcription factor WhiB; Region: Whib; pfam02467 290340011753 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340011754 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340011755 active site 290340011756 metal binding site [ion binding]; metal-binding site 290340011757 interdomain interaction site; other site 290340011758 TrwC relaxase; Region: TrwC; pfam08751 290340011759 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340011760 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 290340011761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011763 TrwC relaxase; Region: TrwC; pfam08751 290340011764 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340011765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011766 Family description; Region: UvrD_C_2; cl15862 290340011767 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340011768 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340011769 active site 290340011770 metal binding site [ion binding]; metal-binding site 290340011771 interdomain interaction site; other site 290340011772 Staphylococcal nuclease homologues; Region: SNc; smart00318 290340011773 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 290340011774 Catalytic site; other site 290340011775 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340011776 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340011777 active site 290340011778 putative substrate binding pocket [chemical binding]; other site 290340011779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011781 Family description; Region: UvrD_C_2; cl15862 290340011782 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340011783 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340011784 active site 290340011785 metal binding site [ion binding]; metal-binding site 290340011786 interdomain interaction site; other site 290340011787 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340011788 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340011789 Magnesium ion binding site [ion binding]; other site 290340011790 Helix-turn-helix domains; Region: HTH; cl00088 290340011791 HTH-like domain; Region: HTH_21; pfam13276 290340011792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340011793 Integrase core domain; Region: rve; cl01316 290340011794 Integrase core domain; Region: rve_3; cl15866 290340011795 Helix-turn-helix domains; Region: HTH; cl00088 290340011796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011797 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340011798 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 290340011799 DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389 290340011800 AAA-like domain; Region: AAA_10; pfam12846 290340011801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011802 Walker A motif; other site 290340011803 ATP binding site [chemical binding]; other site 290340011804 Walker B motif; other site 290340011805 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 290340011806 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 290340011807 HicB family; Region: HicB; pfam05534 290340011808 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340011809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340011810 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 290340011811 Family description; Region: UvrD_C_2; cl15862 290340011812 ParB-like nuclease domain; Region: ParBc; cl02129 290340011813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290340011814 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290340011815 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 290340011816 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290340011817 Cation efflux family; Region: Cation_efflux; cl00316 290340011818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011819 dimerization interface [polypeptide binding]; other site 290340011820 putative DNA binding site [nucleotide binding]; other site 290340011821 putative Zn2+ binding site [ion binding]; other site 290340011822 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340011823 metal-binding site [ion binding] 290340011824 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340011825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340011826 metal-binding site [ion binding] 290340011827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340011828 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340011829 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 290340011830 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340011831 putative homodimer interface [polypeptide binding]; other site 290340011832 putative homotetramer interface [polypeptide binding]; other site 290340011833 putative allosteric switch controlling residues; other site 290340011834 putative metal binding site [ion binding]; other site 290340011835 putative homodimer-homodimer interface [polypeptide binding]; other site 290340011836 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290340011837 dimerization interface [polypeptide binding]; other site 290340011838 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340011839 metal-binding site [ion binding] 290340011840 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340011841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340011842 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340011843 Domain of unknown function (DUF305); Region: DUF305; cl15795 290340011844 Ycf48-like protein; Provisional; Region: PRK13684 290340011845 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290340011846 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340011847 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340011848 catalytic residues [active] 290340011849 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290340011850 putative peptidoglycan binding site; other site 290340011851 NlpC/P60 family; Region: NLPC_P60; cl11438 290340011852 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340011853 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290340011854 AMP-binding enzyme; Region: AMP-binding; cl15778 290340011855 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290340011856 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 290340011857 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340011858 putative trimer interface [polypeptide binding]; other site 290340011859 putative CoA binding site [chemical binding]; other site 290340011860 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340011861 putative trimer interface [polypeptide binding]; other site 290340011862 putative CoA binding site [chemical binding]; other site 290340011863 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 290340011864 Domain of unknown function (DUF305); Region: DUF305; cl15795 290340011865 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290340011866 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 290340011867 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290340011868 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011869 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290340011870 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340011871 ResB-like family; Region: ResB; pfam05140 290340011872 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340011873 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 290340011874 Subunit I/III interface [polypeptide binding]; other site 290340011875 multicopper oxidase; Provisional; Region: PRK10965 290340011876 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011877 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011878 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011879 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 290340011880 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 290340011881 putative active site [active] 290340011882 putative metal binding site [ion binding]; other site 290340011883 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290340011884 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 290340011885 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290340011886 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340011887 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340011888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011889 dimerization interface [polypeptide binding]; other site 290340011890 putative DNA binding site [nucleotide binding]; other site 290340011891 putative Zn2+ binding site [ion binding]; other site 290340011892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011893 dimerization interface [polypeptide binding]; other site 290340011894 putative DNA binding site [nucleotide binding]; other site 290340011895 putative Zn2+ binding site [ion binding]; other site 290340011896 Cation efflux family; Region: Cation_efflux; cl00316 290340011897 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340011898 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340011899 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 290340011900 Copper resistance protein D; Region: CopD; cl00563 290340011901 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 290340011902 Bacterial Ig-like domain; Region: Big_5; cl01012 290340011903 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340011904 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340011905 catalytic residues [active] 290340011906 Vitamin K epoxide reductase family; Region: VKOR; cl01729 290340011907 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290340011908 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 290340011909 Peptidase C26; Region: Peptidase_C26; pfam07722 290340011910 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340011911 catalytic triad [active] 290340011912 Late embryogenesis abundant protein; Region: LEA_2; cl12118 290340011913 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 290340011914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011915 active site 290340011916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340011917 Helix-turn-helix domains; Region: HTH; cl00088 290340011918 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340011919 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290340011920 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 290340011921 Transposase domain (DUF772); Region: DUF772; cl15789 290340011922 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 290340011923 Transposase domain (DUF772); Region: DUF772; cl15789 290340011924 cytosine deaminase; Provisional; Region: PRK05985 290340011925 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340011926 active site 290340011927 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 290340011928 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 290340011929 putative substrate binding site [chemical binding]; other site 290340011930 nucleotide binding site [chemical binding]; other site 290340011931 nucleotide binding site [chemical binding]; other site 290340011932 homodimer interface [polypeptide binding]; other site 290340011933 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 290340011934 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340011935 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340011936 active site 290340011937 putative substrate binding pocket [chemical binding]; other site 290340011938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340011939 Helix-turn-helix domains; Region: HTH; cl00088 290340011940 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340011941 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 290340011942 Putative transposase; Region: Y2_Tnp; pfam04986 290340011943 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 290340011944 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 290340011945 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340011946 catalytic residues [active] 290340011947 catalytic nucleophile [active] 290340011948 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340011949 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340011950 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340011951 Synaptic Site I dimer interface [polypeptide binding]; other site 290340011952 DNA binding site [nucleotide binding] 290340011953 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340011954 DNA-binding interface [nucleotide binding]; DNA binding site 290340011955 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 290340011956 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340011957 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011958 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011959 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 290340011960 Short C-terminal domain; Region: SHOCT; cl01373 290340011961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340011962 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340011963 active site residue [active] 290340011964 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340011965 catalytic residues [active] 290340011966 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340011967 active site residue [active] 290340011968 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340011969 active site residue [active] 290340011970 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 290340011971 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340011972 active site residue [active] 290340011973 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340011974 putative homodimer interface [polypeptide binding]; other site 290340011975 putative homotetramer interface [polypeptide binding]; other site 290340011976 putative allosteric switch controlling residues; other site 290340011977 putative metal binding site [ion binding]; other site 290340011978 putative homodimer-homodimer interface [polypeptide binding]; other site 290340011979 Domain of unknown function DUF302; Region: DUF302; cl01364 290340011980 DsrE/DsrF-like family; Region: DrsE; cl00672 290340011981 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290340011982 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340011983 DNA binding residues [nucleotide binding] 290340011984 dimer interface [polypeptide binding]; other site 290340011985 metal binding site [ion binding]; metal-binding site 290340011986 mercuric reductase; Region: MerA; TIGR02053 290340011987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340011988 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340011989 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340011990 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340011991 catalytic residues [active] 290340011992 catalytic nucleophile [active] 290340011993 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340011994 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340011995 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340011996 Synaptic Site I dimer interface [polypeptide binding]; other site 290340011997 DNA binding site [nucleotide binding] 290340011998 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340011999 DNA-binding interface [nucleotide binding]; DNA binding site 290340012000 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012001 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012002 catalytic residues [active] 290340012003 catalytic nucleophile [active] 290340012004 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012005 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012006 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012007 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012008 DNA binding site [nucleotide binding] 290340012009 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340012010 DNA-binding interface [nucleotide binding]; DNA binding site 290340012011 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 290340012012 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290340012013 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340012014 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290340012015 Walker A/P-loop; other site 290340012016 ATP binding site [chemical binding]; other site 290340012017 Q-loop/lid; other site 290340012018 ABC transporter signature motif; other site 290340012019 Walker B; other site 290340012020 D-loop; other site 290340012021 H-loop/switch region; other site 290340012022 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340012023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340012024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340012025 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340012026 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 290340012027 catalytic loop [active] 290340012028 iron binding site [ion binding]; other site 290340012029 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 290340012030 FAD binding pocket [chemical binding]; other site 290340012031 FAD binding motif [chemical binding]; other site 290340012032 phosphate binding motif [ion binding]; other site 290340012033 beta-alpha-beta structure motif; other site 290340012034 NAD binding pocket [chemical binding]; other site 290340012035 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290340012036 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 290340012037 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 290340012038 inter-subunit interface; other site 290340012039 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290340012040 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340012041 iron-sulfur cluster [ion binding]; other site 290340012042 [2Fe-2S] cluster binding site [ion binding]; other site 290340012043 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 290340012044 putative alpha subunit interface [polypeptide binding]; other site 290340012045 putative active site [active] 290340012046 putative substrate binding site [chemical binding]; other site 290340012047 Fe binding site [ion binding]; other site 290340012048 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290340012049 Helix-turn-helix domains; Region: HTH; cl00088 290340012050 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012051 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340012052 Amidase; Region: Amidase; cl11426 290340012053 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340012054 NMT1-like family; Region: NMT1_2; cl15260 290340012055 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 290340012056 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 290340012057 active site 290340012058 catalytic triad [active] 290340012059 Helix-turn-helix domains; Region: HTH; cl00088 290340012060 HTH-like domain; Region: HTH_21; pfam13276 290340012061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340012062 Integrase core domain; Region: rve; cl01316 290340012063 Integrase core domain; Region: rve_3; cl15866 290340012064 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340012065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012066 Predicted helicase [General function prediction only]; Region: COG4889 290340012067 Restriction endonuclease; Region: Mrr_cat; cl00516 290340012068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340012069 ATP binding site [chemical binding]; other site 290340012070 putative Mg++ binding site [ion binding]; other site 290340012071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012072 Lsr2; Region: Lsr2; pfam11774 290340012073 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290340012074 ThiC-associated domain; Region: ThiC-associated; pfam13667 290340012075 ThiC family; Region: ThiC; cl08031 290340012076 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340012077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340012078 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340012079 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340012080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340012081 Transporter associated domain; Region: CorC_HlyC; cl08393 290340012082 Integral membrane protein TerC family; Region: TerC; cl10468 290340012083 Integral membrane protein TerC family; Region: TerC; cl10468 290340012084 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 290340012085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012086 AAA domain; Region: AAA_22; pfam13401 290340012087 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 290340012088 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340012089 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 290340012090 putative homodimer interface [polypeptide binding]; other site 290340012091 putative active site [active] 290340012092 catalytic site [active] 290340012093 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340012094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340012095 ATP binding site [chemical binding]; other site 290340012096 putative Mg++ binding site [ion binding]; other site 290340012097 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290340012098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340012099 ATP-binding site [chemical binding]; other site 290340012100 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 290340012101 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 290340012102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012104 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012106 Peptidase family M48; Region: Peptidase_M48; cl12018 290340012107 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 290340012108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340012109 salt bridge; other site 290340012110 non-specific DNA binding site [nucleotide binding]; other site 290340012111 sequence-specific DNA binding site [nucleotide binding]; other site 290340012112 HipA N-terminal domain; Region: Couple_hipA; cl11853 290340012113 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290340012114 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290340012115 ParA-like protein; Provisional; Region: PHA02518 290340012116 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012117 Magnesium ion binding site [ion binding]; other site 290340012118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340012122 nucleotide binding region [chemical binding]; other site 290340012123 ATP-binding site [chemical binding]; other site 290340012124 Predicted ATPase [General function prediction only]; Region: COG5293 290340012125 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 290340012126 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 290340012127 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012128 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012129 catalytic residues [active] 290340012130 catalytic nucleophile [active] 290340012131 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012132 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012133 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012134 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012135 DNA binding site [nucleotide binding] 290340012136 Helix-turn-helix domains; Region: HTH; cl00088 290340012137 DNA-binding interface [nucleotide binding]; DNA binding site 290340012138 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 290340012139 putative hydrophobic ligand binding site [chemical binding]; other site 290340012140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012141 Helix-turn-helix domains; Region: HTH; cl00088 290340012142 translocation protein TolB; Provisional; Region: tolB; PRK01029 290340012143 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340012144 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012145 Bacterial Ig-like domain; Region: Big_5; cl01012 290340012146 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012147 Bacterial Ig-like domain; Region: Big_5; cl01012 290340012148 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012149 Bacterial Ig-like domain; Region: Big_5; cl01012 290340012150 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012151 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290340012152 dimerization interface [polypeptide binding]; other site 290340012153 Domain of unknown function (DUF305); Region: DUF305; cl15795 290340012154 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 290340012155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012156 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340012157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012158 dimerization interface [polypeptide binding]; other site 290340012159 putative DNA binding site [nucleotide binding]; other site 290340012160 putative Zn2+ binding site [ion binding]; other site 290340012161 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290340012162 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012163 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340012164 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 290340012165 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340012166 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340012167 catalytic residues [active] 290340012168 Vitamin K epoxide reductase family; Region: VKOR; cl01729 290340012169 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340012170 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340012171 ResB-like family; Region: ResB; pfam05140 290340012172 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340012173 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 290340012174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012175 dimerization interface [polypeptide binding]; other site 290340012176 putative DNA binding site [nucleotide binding]; other site 290340012177 putative Zn2+ binding site [ion binding]; other site 290340012178 Copper resistance protein D; Region: CopD; cl00563 290340012179 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 290340012180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012181 dimerization interface [polypeptide binding]; other site 290340012182 putative DNA binding site [nucleotide binding]; other site 290340012183 putative Zn2+ binding site [ion binding]; other site 290340012184 Cation efflux family; Region: Cation_efflux; cl00316 290340012185 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290340012186 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340012187 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340012188 Bacterial Ig-like domain; Region: Big_5; cl01012 290340012189 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290340012190 Helix-turn-helix domains; Region: HTH; cl00088 290340012191 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340012192 FeoA domain; Region: FeoA; cl00838 290340012193 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 290340012194 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290340012195 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290340012196 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340012197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012198 dimerization interface [polypeptide binding]; other site 290340012199 putative DNA binding site [nucleotide binding]; other site 290340012200 putative Zn2+ binding site [ion binding]; other site 290340012201 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290340012202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012203 dimerization interface [polypeptide binding]; other site 290340012204 putative DNA binding site [nucleotide binding]; other site 290340012205 putative Zn2+ binding site [ion binding]; other site 290340012206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012207 putative DNA binding site [nucleotide binding]; other site 290340012208 dimerization interface [polypeptide binding]; other site 290340012209 putative Zn2+ binding site [ion binding]; other site 290340012210 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340012211 active site 290340012212 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340012213 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340012214 active site 290340012215 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340012216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012217 amine oxidase; Region: PLN02976 290340012218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290340012219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012220 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340012221 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340012222 active site 290340012223 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340012224 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340012225 active site 290340012226 DinB superfamily; Region: DinB_2; pfam12867 290340012227 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 290340012228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290340012229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290340012230 ParB-like partition proteins; Region: parB_part; TIGR00180 290340012231 ParB-like nuclease domain; Region: ParBc; cl02129 290340012232 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340012233 catalytic residues [active] 290340012234 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290340012235 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340012236 dimer interface [polypeptide binding]; other site 290340012237 ssDNA binding site [nucleotide binding]; other site 290340012238 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340012239 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290340012240 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 290340012241 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340012242 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340012243 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340012244 Helix-turn-helix domains; Region: HTH; cl00088 290340012245 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 290340012246 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340012247 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340012248 active site 290340012249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340012250 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340012251 Amino acid permease; Region: AA_permease; pfam00324 290340012252 phenol 2-monooxygenase; Provisional; Region: PRK08294 290340012253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012254 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 290340012255 dimer interface [polypeptide binding]; other site 290340012256 hypothetical protein; Provisional; Region: PRK12764 290340012257 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340012258 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340012259 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340012260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340012261 DNA-binding site [nucleotide binding]; DNA binding site 290340012262 FCD domain; Region: FCD; cl11656 290340012263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012264 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 290340012265 NAD binding site [chemical binding]; other site 290340012266 catalytic residues [active] 290340012267 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340012268 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 290340012269 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290340012270 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012271 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340012272 tetramerization interface [polypeptide binding]; other site 290340012273 NAD(P) binding site [chemical binding]; other site 290340012274 catalytic residues [active] 290340012275 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012276 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340012277 NAD(P) binding site [chemical binding]; other site 290340012278 catalytic residues [active] 290340012279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340012280 classical (c) SDRs; Region: SDR_c; cd05233 290340012281 NAD(P) binding site [chemical binding]; other site 290340012282 active site 290340012283 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340012284 Phosphotransferase enzyme family; Region: APH; pfam01636 290340012285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340012286 active site 290340012287 ATP binding site [chemical binding]; other site 290340012288 substrate binding site [chemical binding]; other site 290340012289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012290 Helix-turn-helix domains; Region: HTH; cl00088 290340012291 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 290340012292 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340012293 inhibitor-cofactor binding pocket; inhibition site 290340012294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340012295 catalytic residue [active] 290340012296 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012297 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340012298 NAD(P) binding site [chemical binding]; other site 290340012299 catalytic residues [active] 290340012300 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290340012301 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340012302 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 290340012303 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340012304 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340012305 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290340012306 non-specific DNA interactions [nucleotide binding]; other site 290340012307 DNA binding site [nucleotide binding] 290340012308 sequence specific DNA binding site [nucleotide binding]; other site 290340012309 putative cAMP binding site [chemical binding]; other site 290340012310 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012311 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340012312 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012313 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340012314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012315 putative substrate translocation pore; other site 290340012316 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340012317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012318 hypothetical protein; Validated; Region: PRK06201 290340012319 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340012320 Isochorismatase family; Region: Isochorismatase; pfam00857 290340012321 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 290340012322 catalytic triad [active] 290340012323 conserved cis-peptide bond; other site 290340012324 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340012325 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290340012326 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 290340012327 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 290340012328 CGNR zinc finger; Region: zf-CGNR; pfam11706 290340012329 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340012330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012331 putative substrate translocation pore; other site 290340012332 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 290340012333 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340012334 Spore germination protein; Region: Spore_permease; cl15802 290340012335 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 290340012336 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340012337 active site 290340012338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340012339 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 290340012340 substrate binding pocket [chemical binding]; other site 290340012341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290340012342 Flavin Reductases; Region: FlaRed; cl00801 290340012343 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290340012344 tetramerization interface [polypeptide binding]; other site 290340012345 active site 290340012346 Right handed beta helix region; Region: Beta_helix; pfam13229 290340012347 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340012348 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290340012349 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012350 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012351 Cupin domain; Region: Cupin_2; cl09118 290340012352 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340012353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340012354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290340012356 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340012357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340012358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340012359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340012360 dimer interface [polypeptide binding]; other site 290340012361 conserved gate region; other site 290340012362 putative PBP binding loops; other site 290340012363 ABC-ATPase subunit interface; other site 290340012364 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340012365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340012366 dimer interface [polypeptide binding]; other site 290340012367 conserved gate region; other site 290340012368 putative PBP binding loops; other site 290340012369 ABC-ATPase subunit interface; other site 290340012370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340012371 DNA binding site [nucleotide binding] 290340012372 domain linker motif; other site 290340012373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340012374 ligand binding site [chemical binding]; other site 290340012375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340012376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340012377 DNA binding site [nucleotide binding] 290340012378 domain linker motif; other site 290340012379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340012380 dimerization interface [polypeptide binding]; other site 290340012381 ligand binding site [chemical binding]; other site 290340012382 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 290340012383 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 290340012384 putative ligand binding site [chemical binding]; other site 290340012385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012386 dimerization interface [polypeptide binding]; other site 290340012387 putative DNA binding site [nucleotide binding]; other site 290340012388 putative Zn2+ binding site [ion binding]; other site 290340012389 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 290340012390 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 290340012391 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 290340012392 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 290340012393 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 290340012394 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 290340012395 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340012396 Amidase; Region: Amidase; cl11426 290340012397 adenylate kinase; Reviewed; Region: adk; PRK00279 290340012398 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340012399 AMP-binding site [chemical binding]; other site 290340012400 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340012401 citrate synthase; Provisional; Region: PRK14033 290340012402 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290340012403 oxalacetate binding site [chemical binding]; other site 290340012404 citrylCoA binding site [chemical binding]; other site 290340012405 coenzyme A binding site [chemical binding]; other site 290340012406 catalytic triad [active] 290340012407 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 290340012408 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340012409 tetramer interface [polypeptide binding]; other site 290340012410 active site 290340012411 Mg2+/Mn2+ binding site [ion binding]; other site 290340012412 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 290340012413 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340012414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340012415 DNA-binding site [nucleotide binding]; DNA binding site 290340012416 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290340012417 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290340012418 AMP-binding enzyme; Region: AMP-binding; cl15778 290340012419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340012420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012421 putative substrate translocation pore; other site 290340012422 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340012423 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340012424 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340012425 Fibronectin type III-like domain; Region: Fn3-like; cl15273 290340012426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012427 Helix-turn-helix domains; Region: HTH; cl00088 290340012428 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290340012429 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340012430 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340012431 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012432 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340012434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340012435 metal-binding site [ion binding] 290340012436 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012437 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290340012438 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340012439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340012440 DNA-binding site [nucleotide binding]; DNA binding site 290340012441 FCD domain; Region: FCD; cl11656 290340012442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340012443 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290340012444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012445 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290340012446 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340012447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340012448 DNA-binding site [nucleotide binding]; DNA binding site 290340012449 FCD domain; Region: FCD; cl11656 290340012450 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290340012451 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290340012452 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290340012453 active site 290340012454 Creatinine amidohydrolase; Region: Creatininase; cl00618 290340012455 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340012456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012457 putative substrate translocation pore; other site 290340012458 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340012459 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290340012460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340012461 catalytic residue [active] 290340012462 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290340012463 homotrimer interaction site [polypeptide binding]; other site 290340012464 putative active site [active] 290340012465 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290340012466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340012468 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340012469 active site residue [active] 290340012470 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 290340012471 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290340012472 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340012473 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290340012474 AMP-binding enzyme; Region: AMP-binding; cl15778 290340012475 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340012476 ethanolamine permease; Region: 2A0305; TIGR00908 290340012477 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340012478 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340012479 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340012480 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340012481 HTH-like domain; Region: HTH_21; pfam13276 290340012482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340012483 Integrase core domain; Region: rve; cl01316 290340012484 Integrase core domain; Region: rve_3; cl15866 290340012485 Helix-turn-helix domains; Region: HTH; cl00088 290340012486 Protein of unknown function (DUF779); Region: DUF779; cl01432 290340012487 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340012488 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012489 NAD(P) binding site [chemical binding]; other site 290340012490 catalytic residues [active] 290340012491 Spore germination protein; Region: Spore_permease; cl15802 290340012492 Helix-turn-helix domains; Region: HTH; cl00088 290340012493 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012494 Isochorismatase family; Region: Isochorismatase; pfam00857 290340012495 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 290340012496 catalytic triad [active] 290340012497 conserved cis-peptide bond; other site 290340012498 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 290340012499 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290340012500 conserved cys residue [active] 290340012501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340012502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340012503 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 290340012504 Helix-turn-helix domains; Region: HTH; cl00088 290340012505 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340012506 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290340012507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012508 Htaa; Region: HtaA; pfam04213 290340012509 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290340012510 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340012511 catalytic triad [active] 290340012512 GAF domain; Region: GAF; cl15785 290340012513 GAF domain; Region: GAF_2; pfam13185 290340012514 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340012515 Helix-turn-helix domains; Region: HTH; cl00088 290340012516 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290340012517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012518 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 290340012519 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 290340012520 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 290340012521 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340012522 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340012523 catalytic triad [active] 290340012524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340012525 classical (c) SDRs; Region: SDR_c; cd05233 290340012526 NAD(P) binding site [chemical binding]; other site 290340012527 active site 290340012528 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340012529 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340012530 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340012531 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 290340012532 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290340012533 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 290340012534 FAD binding pocket [chemical binding]; other site 290340012535 FAD binding motif [chemical binding]; other site 290340012536 catalytic residues [active] 290340012537 NAD binding pocket [chemical binding]; other site 290340012538 phosphate binding motif [ion binding]; other site 290340012539 beta-alpha-beta structure motif; other site 290340012540 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340012541 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012542 NAD(P) binding site [chemical binding]; other site 290340012543 catalytic residues [active] 290340012544 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340012545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340012546 inhibitor-cofactor binding pocket; inhibition site 290340012547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340012548 catalytic residue [active] 290340012549 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340012550 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340012551 NAD binding site [chemical binding]; other site 290340012552 catalytic Zn binding site [ion binding]; other site 290340012553 substrate binding site [chemical binding]; other site 290340012554 structural Zn binding site [ion binding]; other site 290340012555 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012556 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 290340012557 NAD(P) binding site [chemical binding]; other site 290340012558 catalytic residues [active] 290340012559 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340012560 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290340012561 metal binding site [ion binding]; metal-binding site 290340012562 dimer interface [polypeptide binding]; other site 290340012563 Helix-turn-helix domains; Region: HTH; cl00088 290340012564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012565 NAD(P) binding site [chemical binding]; other site 290340012566 active site 290340012567 Sulfatase; Region: Sulfatase; cl10460 290340012568 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012569 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012570 catalytic residues [active] 290340012571 catalytic nucleophile [active] 290340012572 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012573 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012574 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012575 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012576 DNA binding site [nucleotide binding] 290340012577 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340012578 DNA-binding interface [nucleotide binding]; DNA binding site 290340012579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340012580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340012581 active site 290340012582 phosphorylation site [posttranslational modification] 290340012583 intermolecular recognition site; other site 290340012584 dimerization interface [polypeptide binding]; other site 290340012585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340012586 DNA binding site [nucleotide binding] 290340012587 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290340012588 tetramer interface; other site 290340012589 active site 290340012590 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 290340012591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340012592 TM1410 hypothetical-related protein; Region: DUF297; cl00997 290340012593 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290340012594 UDP-glucose 4-epimerase; Region: PLN02240 290340012595 NAD binding site [chemical binding]; other site 290340012596 homodimer interface [polypeptide binding]; other site 290340012597 active site 290340012598 substrate binding site [chemical binding]; other site 290340012599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290340012600 PAS domain; Region: PAS_9; pfam13426 290340012601 putative active site [active] 290340012602 heme pocket [chemical binding]; other site 290340012603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340012604 metal binding site [ion binding]; metal-binding site 290340012605 active site 290340012606 I-site; other site 290340012607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340012608 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 290340012609 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 290340012610 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290340012611 GAF domain; Region: GAF; cl15785 290340012612 ANTAR domain; Region: ANTAR; cl04297 290340012613 Helix-turn-helix domains; Region: HTH; cl00088 290340012614 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340012615 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340012616 substrate binding site [chemical binding]; other site 290340012617 ATP binding site [chemical binding]; other site 290340012618 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 290340012619 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290340012620 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 290340012621 Int/Topo IB signature motif; other site 290340012622 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290340012623 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340012624 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340012625 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290340012626 active site 290340012627 DNA binding site [nucleotide binding] 290340012628 Int/Topo IB signature motif; other site 290340012629 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340012630 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340012631 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290340012632 active site 290340012633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012634 ATP binding site [chemical binding]; other site 290340012635 Walker A motif; other site 290340012636 Walker B motif; other site 290340012637 AAA-like domain; Region: AAA_10; pfam12846 290340012638 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340012639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290340012640 NlpC/P60 family; Region: NLPC_P60; cl11438 290340012641 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 290340012642 nucleotide binding site [chemical binding]; other site