-- dump date 20120504_133457 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521095000001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000002 ATP binding site [chemical binding]; other site 521095000003 Mg2+ binding site [ion binding]; other site 521095000004 G-X-G motif; other site 521095000005 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 521095000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000007 Walker A motif; other site 521095000008 ATP binding site [chemical binding]; other site 521095000009 Walker B motif; other site 521095000010 arginine finger; other site 521095000011 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521095000012 DnaA box-binding interface [nucleotide binding]; other site 521095000013 DNA polymerase III subunit beta; Validated; Region: PRK05643 521095000014 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521095000015 putative DNA binding surface [nucleotide binding]; other site 521095000016 dimer interface [polypeptide binding]; other site 521095000017 beta-clamp/clamp loader binding surface; other site 521095000018 beta-clamp/translesion DNA polymerase binding surface; other site 521095000019 recombination protein F; Reviewed; Region: recF; PRK00064 521095000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000021 Walker A/P-loop; other site 521095000022 ATP binding site [chemical binding]; other site 521095000023 Q-loop/lid; other site 521095000024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000025 ABC transporter signature motif; other site 521095000026 Walker B; other site 521095000027 D-loop; other site 521095000028 H-loop/switch region; other site 521095000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521095000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000031 Mg2+ binding site [ion binding]; other site 521095000032 G-X-G motif; other site 521095000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521095000034 anchoring element; other site 521095000035 dimer interface [polypeptide binding]; other site 521095000036 ATP binding site [chemical binding]; other site 521095000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521095000038 active site 521095000039 putative metal-binding site [ion binding]; other site 521095000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521095000041 DNA gyrase subunit A; Validated; Region: PRK05560 521095000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 521095000043 CAP-like domain; other site 521095000044 active site 521095000045 primary dimer interface [polypeptide binding]; other site 521095000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000052 Bifunctional nuclease; Region: DNase-RNase; cl00553 521095000053 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 521095000054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521095000055 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 521095000056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000057 dimer interface [polypeptide binding]; other site 521095000058 conserved gate region; other site 521095000059 putative PBP binding loops; other site 521095000060 ABC-ATPase subunit interface; other site 521095000061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000062 dimer interface [polypeptide binding]; other site 521095000063 conserved gate region; other site 521095000064 putative PBP binding loops; other site 521095000065 ABC-ATPase subunit interface; other site 521095000066 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521095000067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000068 Walker A/P-loop; other site 521095000069 ATP binding site [chemical binding]; other site 521095000070 Q-loop/lid; other site 521095000071 ABC transporter signature motif; other site 521095000072 Walker B; other site 521095000073 D-loop; other site 521095000074 H-loop/switch region; other site 521095000075 TOBE domain; Region: TOBE_2; cl01440 521095000076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095000077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095000078 DNA binding site [nucleotide binding] 521095000079 domain linker motif; other site 521095000080 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 521095000081 putative dimerization interface [polypeptide binding]; other site 521095000082 putative ligand binding site [chemical binding]; other site 521095000083 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 521095000084 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 521095000085 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 521095000086 G1 box; other site 521095000087 putative GEF interaction site [polypeptide binding]; other site 521095000088 GTP/Mg2+ binding site [chemical binding]; other site 521095000089 Switch I region; other site 521095000090 G2 box; other site 521095000091 G3 box; other site 521095000092 Switch II region; other site 521095000093 G4 box; other site 521095000094 G5 box; other site 521095000095 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 521095000096 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 521095000097 Predicted membrane protein [Function unknown]; Region: COG2860 521095000098 UPF0126 domain; Region: UPF0126; pfam03458 521095000099 UPF0126 domain; Region: UPF0126; pfam03458 521095000100 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 521095000101 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 521095000102 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521095000103 dimer interface [polypeptide binding]; other site 521095000104 ssDNA binding site [nucleotide binding]; other site 521095000105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521095000106 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 521095000107 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 521095000108 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 521095000109 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521095000110 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521095000111 replicative DNA helicase; Region: DnaB; TIGR00665 521095000112 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521095000113 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521095000114 Walker A motif; other site 521095000115 ATP binding site [chemical binding]; other site 521095000116 Walker B motif; other site 521095000117 DNA binding loops [nucleotide binding] 521095000118 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 521095000119 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 521095000120 GDP-binding site [chemical binding]; other site 521095000121 ACT binding site; other site 521095000122 IMP binding site; other site 521095000123 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 521095000124 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 521095000125 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 521095000126 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521095000127 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 521095000128 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 521095000129 dimer interface [polypeptide binding]; other site 521095000130 ADP-ribose binding site [chemical binding]; other site 521095000131 active site 521095000132 nudix motif; other site 521095000133 metal binding site [ion binding]; metal-binding site 521095000134 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095000135 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095000136 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 521095000137 Walker A/P-loop; other site 521095000138 ATP binding site [chemical binding]; other site 521095000139 Q-loop/lid; other site 521095000140 ABC transporter signature motif; other site 521095000141 Walker B; other site 521095000142 D-loop; other site 521095000143 H-loop/switch region; other site 521095000144 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 521095000145 dimer interface [polypeptide binding]; other site 521095000146 pyridoxal binding site [chemical binding]; other site 521095000147 ATP binding site [chemical binding]; other site 521095000148 AIR carboxylase; Region: AIRC; cl00310 521095000149 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 521095000150 active site 521095000151 catalytic site [active] 521095000152 amidophosphoribosyltransferase; Region: purF; TIGR01134 521095000153 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 521095000154 active site 521095000155 tetramer interface [polypeptide binding]; other site 521095000156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095000157 active site 521095000158 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 521095000159 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 521095000160 dimerization interface [polypeptide binding]; other site 521095000161 putative ATP binding site [chemical binding]; other site 521095000162 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 521095000163 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 521095000164 active site 521095000165 substrate binding site [chemical binding]; other site 521095000166 cosubstrate binding site; other site 521095000167 catalytic site [active] 521095000168 OpgC protein; Region: OpgC_C; cl00792 521095000169 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521095000170 Flavin Reductases; Region: FlaRed; cl00801 521095000171 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 521095000172 classical (c) SDRs; Region: SDR_c; cd05233 521095000173 NAD(P) binding site [chemical binding]; other site 521095000174 active site 521095000175 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521095000176 Phosphate transporter family; Region: PHO4; cl00396 521095000177 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 521095000178 PQ loop repeat; Region: PQ-loop; cl12056 521095000179 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 521095000180 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521095000181 CAAX protease self-immunity; Region: Abi; cl00558 521095000182 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 521095000183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095000184 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 521095000185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000186 S-adenosylmethionine binding site [chemical binding]; other site 521095000187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000188 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521095000189 NAD(P) binding site [chemical binding]; other site 521095000190 LDH/MDH dimer interface [polypeptide binding]; other site 521095000191 substrate binding site [chemical binding]; other site 521095000192 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 521095000193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 521095000194 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521095000195 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 521095000196 Walker A/P-loop; other site 521095000197 ATP binding site [chemical binding]; other site 521095000198 Q-loop/lid; other site 521095000199 ABC transporter signature motif; other site 521095000200 Walker B; other site 521095000201 D-loop; other site 521095000202 H-loop/switch region; other site 521095000203 elongation factor G; Reviewed; Region: PRK12740 521095000204 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 521095000205 G1 box; other site 521095000206 putative GEF interaction site [polypeptide binding]; other site 521095000207 GTP/Mg2+ binding site [chemical binding]; other site 521095000208 Switch I region; other site 521095000209 G2 box; other site 521095000210 G3 box; other site 521095000211 Switch II region; other site 521095000212 G4 box; other site 521095000213 G5 box; other site 521095000214 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521095000215 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521095000216 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521095000217 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 521095000218 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 521095000219 TPP-binding site; other site 521095000220 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000221 PYR/PP interface [polypeptide binding]; other site 521095000222 dimer interface [polypeptide binding]; other site 521095000223 TPP binding site [chemical binding]; other site 521095000224 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000225 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 521095000226 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 521095000227 dimer interface [polypeptide binding]; other site 521095000228 active site 521095000229 metal binding site [ion binding]; metal-binding site 521095000230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521095000231 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 521095000232 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095000233 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095000234 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 521095000235 Domain of unknown function DUF21; Region: DUF21; pfam01595 521095000236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521095000237 Transporter associated domain; Region: CorC_HlyC; cl08393 521095000238 cyanophycin synthetase; Provisional; Region: PRK14016 521095000239 YtxH-like protein; Region: YtxH; cl02079 521095000240 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 521095000241 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521095000242 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 521095000243 MgtE intracellular N domain; Region: MgtE_N; cl15244 521095000244 FOG: CBS domain [General function prediction only]; Region: COG0517 521095000245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521095000246 LemA family; Region: LemA; cl00742 521095000247 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 521095000248 nucleoside/Zn binding site; other site 521095000249 dimer interface [polypeptide binding]; other site 521095000250 catalytic motif [active] 521095000251 PUA domain; Region: PUA; cl00607 521095000252 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521095000253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000254 S-adenosylmethionine binding site [chemical binding]; other site 521095000255 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 521095000256 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521095000257 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521095000258 ATP binding site [chemical binding]; other site 521095000259 Mg++ binding site [ion binding]; other site 521095000260 motif III; other site 521095000261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095000262 nucleotide binding region [chemical binding]; other site 521095000263 ATP-binding site [chemical binding]; other site 521095000264 homoserine O-succinyltransferase; Provisional; Region: PRK05368 521095000265 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 521095000266 proposed active site lysine [active] 521095000267 conserved cys residue [active] 521095000268 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521095000269 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521095000270 active site 521095000271 metal binding site [ion binding]; metal-binding site 521095000272 homotetramer interface [polypeptide binding]; other site 521095000273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095000274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000275 DNA-binding site [nucleotide binding]; DNA binding site 521095000276 UTRA domain; Region: UTRA; cl01230 521095000277 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 521095000278 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521095000279 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 521095000280 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521095000281 active site 521095000282 P-loop; other site 521095000283 phosphorylation site [posttranslational modification] 521095000284 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 521095000285 methionine cluster; other site 521095000286 active site 521095000287 phosphorylation site [posttranslational modification] 521095000288 metal binding site [ion binding]; metal-binding site 521095000289 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 521095000290 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 521095000291 motif 1; other site 521095000292 dimer interface [polypeptide binding]; other site 521095000293 active site 521095000294 motif 2; other site 521095000295 motif 3; other site 521095000296 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521095000297 dimerization interface [polypeptide binding]; other site 521095000298 DPS ferroxidase diiron center [ion binding]; other site 521095000299 ion pore; other site 521095000300 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 521095000301 4Fe-4S binding domain; Region: Fer4_5; pfam12801 521095000302 4Fe-4S binding domain; Region: Fer4_5; pfam12801 521095000303 electron transport complex protein RnfC; Provisional; Region: PRK05035 521095000304 4Fe-4S binding domain; Region: Fer4; cl02805 521095000305 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521095000306 catalytic residues [active] 521095000307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095000308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095000309 active site 521095000310 phosphorylation site [posttranslational modification] 521095000311 intermolecular recognition site; other site 521095000312 dimerization interface [polypeptide binding]; other site 521095000313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095000314 DNA binding site [nucleotide binding] 521095000315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 521095000316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095000317 dimer interface [polypeptide binding]; other site 521095000318 phosphorylation site [posttranslational modification] 521095000319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000320 ATP binding site [chemical binding]; other site 521095000321 Mg2+ binding site [ion binding]; other site 521095000322 G-X-G motif; other site 521095000323 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521095000324 active site 521095000325 intersubunit interactions; other site 521095000326 catalytic residue [active] 521095000327 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521095000328 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521095000329 dimer interface [polypeptide binding]; other site 521095000330 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521095000331 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 521095000332 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095000333 HSP70 interaction site [polypeptide binding]; other site 521095000334 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521095000335 substrate binding site [polypeptide binding]; other site 521095000336 dimer interface [polypeptide binding]; other site 521095000337 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 521095000338 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521095000339 DNA binding residues [nucleotide binding] 521095000340 putative dimer interface [polypeptide binding]; other site 521095000341 RelB antitoxin; Region: RelB; cl01171 521095000342 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 521095000343 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 521095000344 Clp amino terminal domain; Region: Clp_N; pfam02861 521095000345 Clp amino terminal domain; Region: Clp_N; pfam02861 521095000346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000347 Walker A motif; other site 521095000348 ATP binding site [chemical binding]; other site 521095000349 Walker B motif; other site 521095000350 arginine finger; other site 521095000351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000352 Walker A motif; other site 521095000353 ATP binding site [chemical binding]; other site 521095000354 Walker B motif; other site 521095000355 arginine finger; other site 521095000356 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 521095000357 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 521095000358 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521095000359 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 521095000360 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095000361 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 521095000362 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 521095000363 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521095000364 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521095000365 sugar binding site [chemical binding]; other site 521095000366 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 521095000367 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521095000368 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 521095000369 putative dimer interface [polypeptide binding]; other site 521095000370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095000371 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521095000372 B3/4 domain; Region: B3_4; cl11458 521095000373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095000374 active site 521095000375 aspartate aminotransferase; Provisional; Region: PRK06836 521095000376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095000377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095000378 homodimer interface [polypeptide binding]; other site 521095000379 catalytic residue [active] 521095000380 putative hydrolase; Validated; Region: PRK09248 521095000381 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 521095000382 active site 521095000383 DNA binding site [nucleotide binding] 521095000384 putative phosphate binding site [ion binding]; other site 521095000385 putative catalytic site [active] 521095000386 metal binding site A [ion binding]; metal-binding site 521095000387 AP binding site [nucleotide binding]; other site 521095000388 metal binding site B [ion binding]; metal-binding site 521095000389 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 521095000390 dihydropteroate synthase; Region: DHPS; TIGR01496 521095000391 substrate binding pocket [chemical binding]; other site 521095000392 dimer interface [polypeptide binding]; other site 521095000393 inhibitor binding site; inhibition site 521095000394 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 521095000395 catalytic center binding site [active] 521095000396 ATP binding site [chemical binding]; other site 521095000397 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 521095000398 Type III pantothenate kinase; Region: Pan_kinase; cl09130 521095000399 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 521095000400 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 521095000401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000402 Walker A motif; other site 521095000403 ATP binding site [chemical binding]; other site 521095000404 Walker B motif; other site 521095000405 arginine finger; other site 521095000406 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 521095000407 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 521095000408 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 521095000409 recombination protein RecR; Reviewed; Region: recR; PRK00076 521095000410 RecR protein; Region: RecR; pfam02132 521095000411 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 521095000412 putative active site [active] 521095000413 putative metal-binding site [ion binding]; other site 521095000414 tetramer interface [polypeptide binding]; other site 521095000415 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 521095000416 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095000417 Rrf2 family protein; Region: rrf2_super; TIGR00738 521095000418 Helix-turn-helix domains; Region: HTH; cl00088 521095000419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521095000420 endonuclease III; Region: ENDO3c; smart00478 521095000421 minor groove reading motif; other site 521095000422 helix-hairpin-helix signature motif; other site 521095000423 active site 521095000424 Rubrerythrin [Energy production and conversion]; Region: COG1592 521095000425 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 521095000426 binuclear metal center [ion binding]; other site 521095000427 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 521095000428 iron binding site [ion binding]; other site 521095000429 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521095000430 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521095000431 minor groove reading motif; other site 521095000432 helix-hairpin-helix signature motif; other site 521095000433 substrate binding pocket [chemical binding]; other site 521095000434 active site 521095000435 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 521095000436 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521095000437 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 521095000438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095000439 ATP binding site [chemical binding]; other site 521095000440 putative Mg++ binding site [ion binding]; other site 521095000441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095000442 nucleotide binding region [chemical binding]; other site 521095000443 ATP-binding site [chemical binding]; other site 521095000444 TRCF domain; Region: TRCF; cl04088 521095000445 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521095000446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000447 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 521095000448 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 521095000449 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 521095000450 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095000451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000452 DNA-binding site [nucleotide binding]; DNA binding site 521095000453 UTRA domain; Region: UTRA; cl01230 521095000454 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095000455 TPP-binding site [chemical binding]; other site 521095000456 dimer interface [polypeptide binding]; other site 521095000457 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095000458 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000459 PYR/PP interface [polypeptide binding]; other site 521095000460 dimer interface [polypeptide binding]; other site 521095000461 TPP binding site [chemical binding]; other site 521095000462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000463 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521095000464 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 521095000465 putative active site [active] 521095000466 metal binding site [ion binding]; metal-binding site 521095000467 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 521095000468 intersubunit interface [polypeptide binding]; other site 521095000469 active site 521095000470 catalytic residue [active] 521095000471 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 521095000472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095000473 FeS/SAM binding site; other site 521095000474 hypothetical protein; Provisional; Region: PRK10977 521095000475 Glycine radical; Region: Gly_radical; cl12026 521095000476 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 521095000477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521095000478 ligand binding site [chemical binding]; other site 521095000479 flexible hinge region; other site 521095000480 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 521095000481 putative switch regulator; other site 521095000482 non-specific DNA interactions [nucleotide binding]; other site 521095000483 DNA binding site [nucleotide binding] 521095000484 sequence specific DNA binding site [nucleotide binding]; other site 521095000485 putative cAMP binding site [chemical binding]; other site 521095000486 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 521095000487 putative kinase; Provisional; Region: PRK09954 521095000488 Helix-turn-helix domains; Region: HTH; cl00088 521095000489 DNA binding residues [nucleotide binding] 521095000490 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 521095000491 substrate binding site [chemical binding]; other site 521095000492 ATP binding site [chemical binding]; other site 521095000493 Sulfatase; Region: Sulfatase; cl10460 521095000494 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 521095000495 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521095000496 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 521095000497 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521095000498 ligand binding site [chemical binding]; other site 521095000499 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521095000500 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 521095000501 Walker A/P-loop; other site 521095000502 ATP binding site [chemical binding]; other site 521095000503 Q-loop/lid; other site 521095000504 ABC transporter signature motif; other site 521095000505 Walker B; other site 521095000506 D-loop; other site 521095000507 H-loop/switch region; other site 521095000508 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 521095000509 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000510 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000511 TM-ABC transporter signature motif; other site 521095000512 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000513 TM-ABC transporter signature motif; other site 521095000514 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521095000515 active site 521095000516 catalytic motif [active] 521095000517 Zn binding site [ion binding]; other site 521095000518 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 521095000519 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 521095000520 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 521095000521 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 521095000522 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 521095000523 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521095000524 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 521095000525 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521095000526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 521095000527 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 521095000528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 521095000529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095000530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095000531 DNA binding site [nucleotide binding] 521095000532 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521095000533 ligand binding site [chemical binding]; other site 521095000534 dimerization interface [polypeptide binding]; other site 521095000535 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 521095000536 P-loop; other site 521095000537 active site 521095000538 phosphorylation site [posttranslational modification] 521095000539 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 521095000540 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095000541 active site 521095000542 phosphorylation site [posttranslational modification] 521095000543 peptidase T; Region: peptidase-T; TIGR01882 521095000544 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521095000545 metal binding site [ion binding]; metal-binding site 521095000546 dimer interface [polypeptide binding]; other site 521095000547 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521095000548 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095000549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095000550 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521095000551 active site 521095000552 motif I; other site 521095000553 motif II; other site 521095000554 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095000555 Helix-turn-helix domains; Region: HTH; cl00088 521095000556 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521095000557 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 521095000558 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 521095000559 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 521095000560 Protein of unknown function (DUF812); Region: DUF812; pfam05667 521095000561 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521095000562 ribonuclease PH; Reviewed; Region: rph; PRK00173 521095000563 Ribonuclease PH; Region: RNase_PH_bact; cd11362 521095000564 hexamer interface [polypeptide binding]; other site 521095000565 active site 521095000566 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521095000567 active site 521095000568 dimerization interface [polypeptide binding]; other site 521095000569 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 521095000570 active site 521095000571 trimer interface [polypeptide binding]; other site 521095000572 allosteric site; other site 521095000573 active site lid [active] 521095000574 hexamer (dimer of trimers) interface [polypeptide binding]; other site 521095000575 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 521095000576 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 521095000577 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 521095000578 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095000579 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095000580 TPP-binding site [chemical binding]; other site 521095000581 dimer interface [polypeptide binding]; other site 521095000582 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095000583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000584 PYR/PP interface [polypeptide binding]; other site 521095000585 dimer interface [polypeptide binding]; other site 521095000586 TPP binding site [chemical binding]; other site 521095000587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000588 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 521095000589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000590 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521095000591 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521095000592 Uncharacterized conserved protein [Function unknown]; Region: COG1912 521095000593 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 521095000594 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 521095000595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095000596 Coenzyme A binding pocket [chemical binding]; other site 521095000597 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 521095000598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521095000599 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521095000600 UGMP family protein; Validated; Region: PRK09604 521095000601 NAD synthetase; Reviewed; Region: nadE; PRK02628 521095000602 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 521095000603 multimer interface [polypeptide binding]; other site 521095000604 active site 521095000605 catalytic triad [active] 521095000606 protein interface 1 [polypeptide binding]; other site 521095000607 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521095000608 homodimer interface [polypeptide binding]; other site 521095000609 NAD binding pocket [chemical binding]; other site 521095000610 ATP binding pocket [chemical binding]; other site 521095000611 Mg binding site [ion binding]; other site 521095000612 active-site loop [active] 521095000613 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521095000614 oligomerisation interface [polypeptide binding]; other site 521095000615 mobile loop; other site 521095000616 roof hairpin; other site 521095000617 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521095000618 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521095000619 ring oligomerisation interface [polypeptide binding]; other site 521095000620 ATP/Mg binding site [chemical binding]; other site 521095000621 stacking interactions; other site 521095000622 hinge regions; other site 521095000623 ferredoxin; Validated; Region: PRK07118 521095000624 4Fe-4S binding domain; Region: Fer4; cl02805 521095000625 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 521095000626 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521095000627 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 521095000628 GTP-binding protein YchF; Reviewed; Region: PRK09601 521095000629 YchF GTPase; Region: YchF; cd01900 521095000630 G1 box; other site 521095000631 GTP/Mg2+ binding site [chemical binding]; other site 521095000632 Switch I region; other site 521095000633 G2 box; other site 521095000634 Switch II region; other site 521095000635 G3 box; other site 521095000636 G4 box; other site 521095000637 G5 box; other site 521095000638 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521095000639 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 521095000640 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 521095000641 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 521095000642 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095000643 GMP synthase; Reviewed; Region: guaA; PRK00074 521095000644 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521095000645 AMP/PPi binding site [chemical binding]; other site 521095000646 candidate oxyanion hole; other site 521095000647 catalytic triad [active] 521095000648 potential glutamine specificity residues [chemical binding]; other site 521095000649 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521095000650 ATP Binding subdomain [chemical binding]; other site 521095000651 Ligand Binding sites [chemical binding]; other site 521095000652 Dimerization subdomain; other site 521095000653 PHP domain; Region: PHP; pfam02811 521095000654 AAA domain; Region: AAA_23; pfam13476 521095000655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000656 Walker A/P-loop; other site 521095000657 ATP binding site [chemical binding]; other site 521095000658 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521095000659 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521095000660 DNA binding site [nucleotide binding] 521095000661 Int/Topo IB signature motif; other site 521095000662 active site 521095000663 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 521095000664 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 521095000665 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 521095000666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000668 Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736 521095000669 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521095000670 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 521095000671 HsdM N-terminal domain; Region: HsdM_N; pfam12161 521095000672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000673 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 521095000674 Mu-like prophage protein [General function prediction only]; Region: COG3941 521095000675 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521095000676 Fic family protein [Function unknown]; Region: COG3177 521095000677 Fic/DOC family; Region: Fic; cl00960 521095000678 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 521095000679 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 521095000680 glutaminase active site [active] 521095000681 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521095000682 dimer interface [polypeptide binding]; other site 521095000683 active site 521095000684 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 521095000685 dimer interface [polypeptide binding]; other site 521095000686 active site 521095000687 Helix-turn-helix domains; Region: HTH; cl00088 521095000688 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 521095000689 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095000690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000691 Walker A/P-loop; other site 521095000692 ATP binding site [chemical binding]; other site 521095000693 Q-loop/lid; other site 521095000694 ABC transporter signature motif; other site 521095000695 Walker B; other site 521095000696 D-loop; other site 521095000697 H-loop/switch region; other site 521095000698 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095000699 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 521095000700 Phospholipid methyltransferase; Region: PEMT; cl00763 521095000701 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095000702 Helix-turn-helix domains; Region: HTH; cl00088 521095000703 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 521095000704 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521095000705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521095000706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000707 Walker A/P-loop; other site 521095000708 ATP binding site [chemical binding]; other site 521095000709 Q-loop/lid; other site 521095000710 ABC transporter signature motif; other site 521095000711 Walker B; other site 521095000712 D-loop; other site 521095000713 H-loop/switch region; other site 521095000714 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 521095000715 catalytic triad [active] 521095000716 active site nucleophile [active] 521095000717 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095000718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000719 DNA-binding site [nucleotide binding]; DNA binding site 521095000720 Predicted membrane protein [General function prediction only]; Region: COG4194 521095000721 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 521095000722 RelB antitoxin; Region: RelB; cl01171 521095000723 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 521095000724 Predicted transcriptional regulator [Transcription]; Region: COG1959 521095000725 Helix-turn-helix domains; Region: HTH; cl00088 521095000726 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 521095000727 Isochorismatase family; Region: Isochorismatase; pfam00857 521095000728 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521095000729 catalytic triad [active] 521095000730 conserved cis-peptide bond; other site 521095000731 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095000732 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521095000733 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 521095000734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095000735 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095000736 Walker A/P-loop; other site 521095000737 ATP binding site [chemical binding]; other site 521095000738 Q-loop/lid; other site 521095000739 ABC transporter signature motif; other site 521095000740 Walker B; other site 521095000741 D-loop; other site 521095000742 H-loop/switch region; other site 521095000743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095000744 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521095000745 FtsX-like permease family; Region: FtsX; cl15850 521095000746 Uncharacterized conserved protein [Function unknown]; Region: COG2014 521095000747 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 521095000748 Domain of unknown function (DUF364); Region: DUF364; pfam04016 521095000749 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 521095000750 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 521095000751 metal binding site [ion binding]; metal-binding site 521095000752 dimer interface [polypeptide binding]; other site 521095000753 xanthine permease; Region: pbuX; TIGR03173 521095000754 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 521095000755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 521095000756 YheO-like PAS domain; Region: PAS_6; pfam08348 521095000757 Helix-turn-helix domains; Region: HTH; cl00088 521095000758 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 521095000759 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095000760 active site 521095000761 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 521095000762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000763 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 521095000764 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 521095000765 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 521095000766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 521095000767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 521095000768 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 521095000769 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 521095000770 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095000771 catalytic residue [active] 521095000772 peptidase; Reviewed; Region: PRK13004 521095000773 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 521095000774 putative metal binding site [ion binding]; other site 521095000775 putative dimer interface [polypeptide binding]; other site 521095000776 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 521095000777 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521095000778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000779 carbamate kinase; Reviewed; Region: PRK12686 521095000780 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 521095000781 putative substrate binding site [chemical binding]; other site 521095000782 nucleotide binding site [chemical binding]; other site 521095000783 nucleotide binding site [chemical binding]; other site 521095000784 homodimer interface [polypeptide binding]; other site 521095000785 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 521095000786 Ligand binding site; other site 521095000787 metal-binding site 521095000788 phenylhydantoinase; Validated; Region: PRK08323 521095000789 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 521095000790 tetramer interface [polypeptide binding]; other site 521095000791 active site 521095000792 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521095000793 homotrimer interaction site [polypeptide binding]; other site 521095000794 putative active site [active] 521095000795 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 521095000796 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 521095000797 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 521095000798 CPxP motif; other site 521095000799 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521095000800 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521095000801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095000802 catalytic residue [active] 521095000803 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 521095000804 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 521095000805 selenium donor protein; Region: selD; TIGR00476 521095000806 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 521095000807 dimerization interface [polypeptide binding]; other site 521095000808 putative ATP binding site [chemical binding]; other site 521095000809 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 521095000810 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 521095000811 XdhC Rossmann domain; Region: XdhC_C; pfam13478 521095000812 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 521095000813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521095000814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000815 dimer interface [polypeptide binding]; other site 521095000816 conserved gate region; other site 521095000817 putative PBP binding loops; other site 521095000818 ABC-ATPase subunit interface; other site 521095000819 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 521095000820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000821 Walker A/P-loop; other site 521095000822 ATP binding site [chemical binding]; other site 521095000823 Q-loop/lid; other site 521095000824 ABC transporter signature motif; other site 521095000825 Walker B; other site 521095000826 D-loop; other site 521095000827 H-loop/switch region; other site 521095000828 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 521095000829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095000830 FeS/SAM binding site; other site 521095000831 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 521095000832 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 521095000833 trimer interface [polypeptide binding]; other site 521095000834 dimer interface [polypeptide binding]; other site 521095000835 putative active site [active] 521095000836 MOSC domain; Region: MOSC; pfam03473 521095000837 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 521095000838 putative MPT binding site; other site 521095000839 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 521095000840 MPT binding site; other site 521095000841 trimer interface [polypeptide binding]; other site 521095000842 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095000843 Uncharacterized conserved protein [Function unknown]; Region: COG2461 521095000844 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095000845 ApbE family; Region: ApbE; cl00643 521095000846 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 521095000847 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 521095000848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095000849 Zn2+ binding site [ion binding]; other site 521095000850 Mg2+ binding site [ion binding]; other site 521095000851 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 521095000852 substrate binding site [chemical binding]; other site 521095000853 THF binding site; other site 521095000854 zinc-binding site [ion binding]; other site 521095000855 Predicted transcriptional regulator [Transcription]; Region: COG2378 521095000856 WYL domain; Region: WYL; cl14852 521095000857 HIRAN domain; Region: HIRAN; cl07418 521095000858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521095000859 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521095000860 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 521095000861 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095000862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000863 Walker A/P-loop; other site 521095000864 ATP binding site [chemical binding]; other site 521095000865 Q-loop/lid; other site 521095000866 ABC transporter signature motif; other site 521095000867 Walker B; other site 521095000868 D-loop; other site 521095000869 H-loop/switch region; other site 521095000870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095000871 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095000872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000873 Walker A/P-loop; other site 521095000874 ATP binding site [chemical binding]; other site 521095000875 Q-loop/lid; other site 521095000876 ABC transporter signature motif; other site 521095000877 Walker B; other site 521095000878 D-loop; other site 521095000879 H-loop/switch region; other site 521095000880 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 521095000881 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 521095000882 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521095000883 ABC-ATPase subunit interface; other site 521095000884 dimer interface [polypeptide binding]; other site 521095000885 putative PBP binding regions; other site 521095000886 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521095000887 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 521095000888 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 521095000889 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 521095000890 metal binding site [ion binding]; metal-binding site 521095000891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521095000892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000893 NAD(P) binding site [chemical binding]; other site 521095000894 active site 521095000895 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 521095000896 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 521095000897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095000898 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 521095000899 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 521095000900 Sulfatase; Region: Sulfatase; cl10460 521095000901 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 521095000902 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 521095000903 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 521095000904 putative active site [active] 521095000905 catalytic site [active] 521095000906 putative metal binding site [ion binding]; other site 521095000907 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 521095000908 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095000909 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095000910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000911 S-adenosylmethionine binding site [chemical binding]; other site 521095000912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095000913 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521095000914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095000915 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 521095000916 active site 521095000917 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 521095000918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000919 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 521095000920 NAD-dependent deacetylase; Provisional; Region: PRK00481 521095000921 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 521095000922 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 521095000923 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521095000924 DRTGG domain; Region: DRTGG; cl12147 521095000925 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521095000926 DHH family; Region: DHH; pfam01368 521095000927 DHHA2 domain; Region: DHHA2; pfam02833 521095000928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 521095000929 MORN repeat; Region: MORN; cl14787 521095000930 OpgC protein; Region: OpgC_C; cl00792 521095000931 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521095000932 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521095000933 active site 521095000934 catalytic triad [active] 521095000935 oxyanion hole [active] 521095000936 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 521095000937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095000938 Walker A/P-loop; other site 521095000939 ATP binding site [chemical binding]; other site 521095000940 Q-loop/lid; other site 521095000941 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095000942 ABC transporter; Region: ABC_tran_2; pfam12848 521095000943 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095000944 Ferritin-like domain; Region: Ferritin; pfam00210 521095000945 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 521095000946 ferroxidase diiron center [ion binding]; other site 521095000947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 521095000948 EamA-like transporter family; Region: EamA; cl01037 521095000949 EamA-like transporter family; Region: EamA; cl01037 521095000950 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 521095000951 active site 521095000952 homodimer interface [polypeptide binding]; other site 521095000953 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 521095000954 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 521095000955 active site 521095000956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 521095000957 hypothetical protein; Provisional; Region: PRK13663 521095000958 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 521095000959 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 521095000960 dimer interface [polypeptide binding]; other site 521095000961 putative active site [active] 521095000962 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 521095000963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095000964 non-specific DNA binding site [nucleotide binding]; other site 521095000965 salt bridge; other site 521095000966 sequence-specific DNA binding site [nucleotide binding]; other site 521095000967 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 521095000968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521095000969 Helix-turn-helix domains; Region: HTH; cl00088 521095000970 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521095000971 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 521095000972 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 521095000973 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 521095000974 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 521095000975 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 521095000976 active site 521095000977 Zn binding site [ion binding]; other site 521095000978 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 521095000979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095000980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095000981 homodimer interface [polypeptide binding]; other site 521095000982 catalytic residue [active] 521095000983 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 521095000984 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521095000985 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521095000986 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521095000987 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521095000988 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 521095000989 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521095000990 P-loop; other site 521095000991 active site 521095000992 phosphorylation site [posttranslational modification] 521095000993 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521095000994 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095000995 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095000996 putative substrate binding site [chemical binding]; other site 521095000997 putative ATP binding site [chemical binding]; other site 521095000998 Transcriptional regulator; Region: Transcrip_reg; cl00361 521095000999 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521095001000 Helix-turn-helix domains; Region: HTH; cl00088 521095001001 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 521095001002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095001003 active site 521095001004 phosphorylation site [posttranslational modification] 521095001005 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 521095001006 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095001007 P-loop; other site 521095001008 active site 521095001009 phosphorylation site [posttranslational modification] 521095001010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095001011 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 521095001012 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 521095001013 intersubunit interface [polypeptide binding]; other site 521095001014 active site 521095001015 Zn2+ binding site [ion binding]; other site 521095001016 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 521095001017 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521095001018 AP (apurinic/apyrimidinic) site pocket; other site 521095001019 DNA interaction; other site 521095001020 Metal-binding active site; metal-binding site 521095001021 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521095001022 active site 521095001023 intersubunit interactions; other site 521095001024 catalytic residue [active] 521095001025 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095001026 TPP-binding site [chemical binding]; other site 521095001027 dimer interface [polypeptide binding]; other site 521095001028 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095001029 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095001030 PYR/PP interface [polypeptide binding]; other site 521095001031 dimer interface [polypeptide binding]; other site 521095001032 TPP binding site [chemical binding]; other site 521095001033 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095001034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001035 non-specific DNA binding site [nucleotide binding]; other site 521095001036 salt bridge; other site 521095001037 sequence-specific DNA binding site [nucleotide binding]; other site 521095001038 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001039 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095001040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001041 Walker A/P-loop; other site 521095001042 ATP binding site [chemical binding]; other site 521095001043 Q-loop/lid; other site 521095001044 ABC transporter signature motif; other site 521095001045 Walker B; other site 521095001046 D-loop; other site 521095001047 H-loop/switch region; other site 521095001048 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 521095001049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095001050 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 521095001051 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 521095001052 FAD binding pocket [chemical binding]; other site 521095001053 FAD binding motif [chemical binding]; other site 521095001054 phosphate binding motif [ion binding]; other site 521095001055 beta-alpha-beta structure motif; other site 521095001056 NAD binding pocket [chemical binding]; other site 521095001057 Iron coordination center [ion binding]; other site 521095001058 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521095001059 putative active site [active] 521095001060 catalytic residue [active] 521095001061 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 521095001062 putative substrate binding pocket [chemical binding]; other site 521095001063 AC domain interface; other site 521095001064 catalytic triad [active] 521095001065 AB domain interface; other site 521095001066 interchain disulfide; other site 521095001067 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521095001068 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521095001069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095001070 active site 521095001071 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 521095001072 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 521095001073 Substrate binding site; other site 521095001074 Mg++ binding site; other site 521095001075 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 521095001076 active site 521095001077 substrate binding site [chemical binding]; other site 521095001078 CoA binding site [chemical binding]; other site 521095001079 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 521095001080 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 521095001081 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 521095001082 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521095001083 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521095001084 substrate binding pocket [chemical binding]; other site 521095001085 chain length determination region; other site 521095001086 substrate-Mg2+ binding site; other site 521095001087 catalytic residues [active] 521095001088 aspartate-rich region 1; other site 521095001089 active site lid residues [active] 521095001090 aspartate-rich region 2; other site 521095001091 UDP-glucose 4-epimerase; Region: PLN02240 521095001092 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 521095001093 NAD binding site [chemical binding]; other site 521095001094 homodimer interface [polypeptide binding]; other site 521095001095 active site 521095001096 substrate binding site [chemical binding]; other site 521095001097 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 521095001098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001099 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095001100 Walker A/P-loop; other site 521095001101 ATP binding site [chemical binding]; other site 521095001102 Q-loop/lid; other site 521095001103 ABC transporter signature motif; other site 521095001104 Walker B; other site 521095001105 D-loop; other site 521095001106 H-loop/switch region; other site 521095001107 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521095001108 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095001109 FtsX-like permease family; Region: FtsX; cl15850 521095001110 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 521095001111 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 521095001112 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 521095001113 dimerization interface [polypeptide binding]; other site 521095001114 ATP binding site [chemical binding]; other site 521095001115 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 521095001116 dimerization interface [polypeptide binding]; other site 521095001117 ATP binding site [chemical binding]; other site 521095001118 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 521095001119 putative active site [active] 521095001120 catalytic triad [active] 521095001121 Cobalt transport protein; Region: CbiQ; cl00463 521095001122 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 521095001123 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095001124 Walker A/P-loop; other site 521095001125 ATP binding site [chemical binding]; other site 521095001126 Q-loop/lid; other site 521095001127 ABC transporter signature motif; other site 521095001128 Walker B; other site 521095001129 D-loop; other site 521095001130 H-loop/switch region; other site 521095001131 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 521095001132 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095001133 Walker A/P-loop; other site 521095001134 ATP binding site [chemical binding]; other site 521095001135 Q-loop/lid; other site 521095001136 ABC transporter signature motif; other site 521095001137 Walker B; other site 521095001138 D-loop; other site 521095001139 H-loop/switch region; other site 521095001140 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 521095001141 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521095001142 FAD binding domain; Region: FAD_binding_4; pfam01565 521095001143 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521095001144 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521095001145 active site 521095001146 ADP/pyrophosphate binding site [chemical binding]; other site 521095001147 dimerization interface [polypeptide binding]; other site 521095001148 allosteric effector site; other site 521095001149 fructose-1,6-bisphosphate binding site; other site 521095001150 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521095001151 active site 521095001152 ADP/pyrophosphate binding site [chemical binding]; other site 521095001153 dimerization interface [polypeptide binding]; other site 521095001154 allosteric effector site; other site 521095001155 fructose-1,6-bisphosphate binding site; other site 521095001156 enolase; Provisional; Region: eno; PRK00077 521095001157 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521095001158 dimer interface [polypeptide binding]; other site 521095001159 metal binding site [ion binding]; metal-binding site 521095001160 substrate binding pocket [chemical binding]; other site 521095001161 Cupin domain; Region: Cupin_2; cl09118 521095001162 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 521095001163 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001164 Family description; Region: UvrD_C_2; cl15862 521095001165 Predicted GTPase [General function prediction only]; Region: COG0218 521095001166 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 521095001167 G1 box; other site 521095001168 GTP/Mg2+ binding site [chemical binding]; other site 521095001169 Switch I region; other site 521095001170 G2 box; other site 521095001171 G3 box; other site 521095001172 Switch II region; other site 521095001173 G4 box; other site 521095001174 G5 box; other site 521095001175 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095001176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001177 Walker A/P-loop; other site 521095001178 ATP binding site [chemical binding]; other site 521095001179 Q-loop/lid; other site 521095001180 ABC transporter signature motif; other site 521095001181 Walker B; other site 521095001182 D-loop; other site 521095001183 H-loop/switch region; other site 521095001184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095001185 Helix-turn-helix domains; Region: HTH; cl00088 521095001186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095001187 dimerization interface [polypeptide binding]; other site 521095001188 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 521095001189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095001190 active site 521095001191 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521095001192 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521095001193 putative dimer interface [polypeptide binding]; other site 521095001194 putative anticodon binding site; other site 521095001195 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521095001196 homodimer interface [polypeptide binding]; other site 521095001197 motif 1; other site 521095001198 motif 2; other site 521095001199 active site 521095001200 motif 3; other site 521095001201 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001202 catalytic core [active] 521095001203 CHAD domain; Region: CHAD; cl10506 521095001204 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 521095001205 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521095001206 homodimer interface [polypeptide binding]; other site 521095001207 substrate-cofactor binding pocket; other site 521095001208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001209 catalytic residue [active] 521095001210 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521095001211 MatE; Region: MatE; cl10513 521095001212 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 521095001213 dipeptidase PepV; Reviewed; Region: PRK07318 521095001214 active site 521095001215 metal binding site [ion binding]; metal-binding site 521095001216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001217 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095001218 Walker A/P-loop; other site 521095001219 ATP binding site [chemical binding]; other site 521095001220 Q-loop/lid; other site 521095001221 ABC transporter signature motif; other site 521095001222 Walker B; other site 521095001223 D-loop; other site 521095001224 H-loop/switch region; other site 521095001225 FtsX-like permease family; Region: FtsX; cl15850 521095001226 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 521095001227 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521095001228 Peptidase M16C associated; Region: M16C_assoc; pfam08367 521095001229 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521095001230 EamA-like transporter family; Region: EamA; cl01037 521095001231 EamA-like transporter family; Region: EamA; cl01037 521095001232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521095001233 SlyX; Region: SlyX; cl01090 521095001234 Bacitracin resistance protein BacA; Region: BacA; cl00858 521095001235 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521095001236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001237 Family description; Region: UvrD_C_2; cl15862 521095001238 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521095001239 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521095001240 Phosphate transporter family; Region: PHO4; cl00396 521095001241 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521095001242 Asp23 family; Region: Asp23; cl00574 521095001243 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 521095001244 active site 521095001245 substrate binding site [chemical binding]; other site 521095001246 Phosphotransferase enzyme family; Region: APH; pfam01636 521095001247 ATP binding site [chemical binding]; other site 521095001248 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521095001249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001250 dimer interface [polypeptide binding]; other site 521095001251 conserved gate region; other site 521095001252 putative PBP binding loops; other site 521095001253 ABC-ATPase subunit interface; other site 521095001254 NMT1/THI5 like; Region: NMT1; pfam09084 521095001255 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 521095001256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001257 Walker A/P-loop; other site 521095001258 ATP binding site [chemical binding]; other site 521095001259 Q-loop/lid; other site 521095001260 ABC transporter signature motif; other site 521095001261 Walker B; other site 521095001262 D-loop; other site 521095001263 H-loop/switch region; other site 521095001264 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 521095001265 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521095001266 oligomer interface [polypeptide binding]; other site 521095001267 putative active site [active] 521095001268 metal binding site [ion binding]; metal-binding site 521095001269 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 521095001270 hypothetical protein; Provisional; Region: PRK08185 521095001271 intersubunit interface [polypeptide binding]; other site 521095001272 active site 521095001273 zinc binding site [ion binding]; other site 521095001274 Na+ binding site [ion binding]; other site 521095001275 Helix-turn-helix domains; Region: HTH; cl00088 521095001276 Rrf2 family protein; Region: rrf2_super; TIGR00738 521095001277 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521095001278 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521095001279 trimerization site [polypeptide binding]; other site 521095001280 active site 521095001281 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521095001282 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521095001283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095001284 catalytic residue [active] 521095001285 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 521095001286 FeS assembly protein SufB; Region: sufB; TIGR01980 521095001287 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 521095001288 FeS assembly ATPase SufC; Region: sufC; TIGR01978 521095001289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001290 Walker A/P-loop; other site 521095001291 ATP binding site [chemical binding]; other site 521095001292 Q-loop/lid; other site 521095001293 ABC transporter signature motif; other site 521095001294 Walker B; other site 521095001295 D-loop; other site 521095001296 H-loop/switch region; other site 521095001297 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 521095001298 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 521095001299 dimer interface [polypeptide binding]; other site 521095001300 motif 1; other site 521095001301 active site 521095001302 motif 2; other site 521095001303 motif 3; other site 521095001304 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521095001305 anticodon binding site; other site 521095001306 Helix-turn-helix domains; Region: HTH; cl00088 521095001307 HTH-like domain; Region: HTH_21; pfam13276 521095001308 Integrase core domain; Region: rve; cl01316 521095001309 Integrase core domain; Region: rve_3; cl15866 521095001310 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 521095001311 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095001312 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 521095001313 Walker A/P-loop; other site 521095001314 ATP binding site [chemical binding]; other site 521095001315 Q-loop/lid; other site 521095001316 ABC transporter signature motif; other site 521095001317 Walker B; other site 521095001318 D-loop; other site 521095001319 H-loop/switch region; other site 521095001320 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 521095001321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095001322 Helix-turn-helix domains; Region: HTH; cl00088 521095001323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095001324 dimerization interface [polypeptide binding]; other site 521095001325 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 521095001326 active site 521095001327 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 521095001328 4Fe-4S binding domain; Region: Fer4; cl02805 521095001329 4Fe-4S binding domain; Region: Fer4; cl02805 521095001330 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 521095001331 Glucan-binding protein C; Region: GbpC; pfam08363 521095001332 phosphoglycolate phosphatase; Provisional; Region: PRK13222 521095001333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095001334 motif II; other site 521095001335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 521095001336 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521095001337 active site 521095001338 ATP binding site [chemical binding]; other site 521095001339 substrate binding site [chemical binding]; other site 521095001340 activation loop (A-loop); other site 521095001341 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095001342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001343 Walker A/P-loop; other site 521095001344 ATP binding site [chemical binding]; other site 521095001345 Q-loop/lid; other site 521095001346 ABC transporter signature motif; other site 521095001347 Walker B; other site 521095001348 D-loop; other site 521095001349 H-loop/switch region; other site 521095001350 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521095001351 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521095001352 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521095001353 dimer interface [polypeptide binding]; other site 521095001354 anticodon binding site; other site 521095001355 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 521095001356 motif 1; other site 521095001357 dimer interface [polypeptide binding]; other site 521095001358 active site 521095001359 motif 2; other site 521095001360 GAD domain; Region: GAD; pfam02938 521095001361 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 521095001362 active site 521095001363 motif 3; other site 521095001364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001365 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095001366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001367 Walker A/P-loop; other site 521095001368 ATP binding site [chemical binding]; other site 521095001369 Q-loop/lid; other site 521095001370 ABC transporter signature motif; other site 521095001371 Walker B; other site 521095001372 D-loop; other site 521095001373 H-loop/switch region; other site 521095001374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001375 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095001376 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 521095001377 Walker A/P-loop; other site 521095001378 ATP binding site [chemical binding]; other site 521095001379 Q-loop/lid; other site 521095001380 ABC transporter signature motif; other site 521095001381 Walker B; other site 521095001382 D-loop; other site 521095001383 H-loop/switch region; other site 521095001384 CrcB-like protein; Region: CRCB; cl09114 521095001385 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 521095001386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095001387 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 521095001388 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 521095001389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521095001390 putative substrate translocation pore; other site 521095001391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001392 catalytic core [active] 521095001393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001394 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 521095001395 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521095001396 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521095001397 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 521095001398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095001399 substrate binding pocket [chemical binding]; other site 521095001400 membrane-bound complex binding site; other site 521095001401 hinge residues; other site 521095001402 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 521095001403 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001405 dimer interface [polypeptide binding]; other site 521095001406 conserved gate region; other site 521095001407 putative PBP binding loops; other site 521095001408 ABC-ATPase subunit interface; other site 521095001409 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 521095001410 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 521095001411 Walker A/P-loop; other site 521095001412 ATP binding site [chemical binding]; other site 521095001413 Q-loop/lid; other site 521095001414 ABC transporter signature motif; other site 521095001415 Walker B; other site 521095001416 D-loop; other site 521095001417 H-loop/switch region; other site 521095001418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095001419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095001420 DNA binding site [nucleotide binding] 521095001421 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 521095001422 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 521095001423 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521095001424 protein binding site [polypeptide binding]; other site 521095001425 RmuC family; Region: RmuC; pfam02646 521095001426 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521095001427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001428 Walker A/P-loop; other site 521095001429 ATP binding site [chemical binding]; other site 521095001430 Q-loop/lid; other site 521095001431 ABC transporter signature motif; other site 521095001432 Walker B; other site 521095001433 D-loop; other site 521095001434 H-loop/switch region; other site 521095001435 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 521095001436 putative homotetramer interface [polypeptide binding]; other site 521095001437 putative homodimer interface [polypeptide binding]; other site 521095001438 putative allosteric switch controlling residues; other site 521095001439 putative metal binding site [ion binding]; other site 521095001440 putative homodimer-homodimer interface [polypeptide binding]; other site 521095001441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521095001442 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095001443 metal-binding site [ion binding] 521095001444 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095001445 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095001446 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095001447 metal-binding site [ion binding] 521095001448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095001449 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 521095001450 active site 521095001451 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 521095001452 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 521095001453 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 521095001454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521095001455 active site 521095001456 metal binding site [ion binding]; metal-binding site 521095001457 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 521095001458 putative active site [active] 521095001459 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001461 dimer interface [polypeptide binding]; other site 521095001462 conserved gate region; other site 521095001463 putative PBP binding loops; other site 521095001464 ABC-ATPase subunit interface; other site 521095001465 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001467 dimer interface [polypeptide binding]; other site 521095001468 conserved gate region; other site 521095001469 putative PBP binding loops; other site 521095001470 ABC-ATPase subunit interface; other site 521095001471 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 521095001472 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 521095001473 Walker A/P-loop; other site 521095001474 ATP binding site [chemical binding]; other site 521095001475 Q-loop/lid; other site 521095001476 ABC transporter signature motif; other site 521095001477 Walker B; other site 521095001478 D-loop; other site 521095001479 H-loop/switch region; other site 521095001480 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 521095001481 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095001482 substrate binding pocket [chemical binding]; other site 521095001483 membrane-bound complex binding site; other site 521095001484 hinge residues; other site 521095001485 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 521095001486 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521095001487 active site 521095001488 catalytic triad [active] 521095001489 oxyanion hole [active] 521095001490 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 521095001491 recombination factor protein RarA; Reviewed; Region: PRK13342 521095001492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095001493 Walker A motif; other site 521095001494 ATP binding site [chemical binding]; other site 521095001495 Walker B motif; other site 521095001496 arginine finger; other site 521095001497 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 521095001498 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521095001499 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 521095001500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521095001501 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521095001502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521095001503 DNA binding residues [nucleotide binding] 521095001504 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521095001505 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 521095001506 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 521095001507 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 521095001508 motif 1; other site 521095001509 active site 521095001510 motif 2; other site 521095001511 motif 3; other site 521095001512 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 521095001513 DHHA1 domain; Region: DHHA1; pfam02272 521095001514 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 521095001515 YceG-like family; Region: YceG; pfam02618 521095001516 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521095001517 dimerization interface [polypeptide binding]; other site 521095001518 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 521095001519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095001520 active site 521095001521 motif I; other site 521095001522 motif II; other site 521095001523 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521095001524 Shikimate kinase; Region: SKI; pfam01202 521095001525 ADP binding site [chemical binding]; other site 521095001526 magnesium binding site [ion binding]; other site 521095001527 putative shikimate binding site; other site 521095001528 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521095001529 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521095001530 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 521095001531 active site 521095001532 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 521095001533 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 521095001534 active pocket/dimerization site; other site 521095001535 active site 521095001536 phosphorylation site [posttranslational modification] 521095001537 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 521095001538 active site 521095001539 phosphorylation site [posttranslational modification] 521095001540 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 521095001541 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 521095001542 Domain of unknown function (DUF956); Region: DUF956; cl01917 521095001543 elongation factor P; Validated; Region: PRK00529 521095001544 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521095001545 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521095001546 RNA binding site [nucleotide binding]; other site 521095001547 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521095001548 RNA binding site [nucleotide binding]; other site 521095001549 Asp23 family; Region: Asp23; cl00574 521095001550 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 521095001551 putative RNA binding site [nucleotide binding]; other site 521095001552 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 521095001553 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 521095001554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521095001555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095001556 S-adenosylmethionine binding site [chemical binding]; other site 521095001557 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 521095001558 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 521095001559 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 521095001560 Walker A/P-loop; other site 521095001561 ATP binding site [chemical binding]; other site 521095001562 Q-loop/lid; other site 521095001563 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 521095001564 ABC transporter signature motif; other site 521095001565 Walker B; other site 521095001566 D-loop; other site 521095001567 H-loop/switch region; other site 521095001568 CTP synthetase; Validated; Region: pyrG; PRK05380 521095001569 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521095001570 Catalytic site [active] 521095001571 active site 521095001572 UTP binding site [chemical binding]; other site 521095001573 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521095001574 active site 521095001575 putative oxyanion hole; other site 521095001576 catalytic triad [active] 521095001577 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 521095001578 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521095001579 Int/Topo IB signature motif; other site 521095001580 active site 521095001581 cell division protein MraZ; Reviewed; Region: PRK00326 521095001582 MraZ protein; Region: MraZ; pfam02381 521095001583 MraZ protein; Region: MraZ; pfam02381 521095001584 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 521095001585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095001586 Septum formation initiator; Region: DivIC; cl11433 521095001587 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521095001588 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095001589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095001590 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 521095001591 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095001592 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001593 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 521095001594 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521095001595 Mg++ binding site [ion binding]; other site 521095001596 putative catalytic motif [active] 521095001597 putative substrate binding site [chemical binding]; other site 521095001598 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 521095001599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095001601 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521095001602 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521095001603 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521095001604 active site 521095001605 homodimer interface [polypeptide binding]; other site 521095001606 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 521095001607 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095001608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001609 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095001610 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521095001611 FAD binding domain; Region: FAD_binding_4; pfam01565 521095001612 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521095001613 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 521095001614 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 521095001615 cell division protein FtsZ; Validated; Region: PRK09330 521095001616 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521095001617 nucleotide binding site [chemical binding]; other site 521095001618 SulA interaction site; other site 521095001619 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 521095001620 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 521095001621 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 521095001622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095001623 catalytic residue [active] 521095001624 Protein of unknown function (DUF552); Region: DUF552; cl00775 521095001625 YGGT family; Region: YGGT; cl00508 521095001626 DivIVA protein; Region: DivIVA; pfam05103 521095001627 DivIVA domain; Region: DivI1A_domain; TIGR03544 521095001628 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 521095001629 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 521095001630 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095001631 FeS/SAM binding site; other site 521095001632 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521095001633 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 521095001634 active site 521095001635 NTP binding site [chemical binding]; other site 521095001636 metal binding triad [ion binding]; metal-binding site 521095001637 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521095001638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095001639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095001640 Predicted membrane protein [Function unknown]; Region: COG1511 521095001641 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521095001642 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521095001643 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521095001644 Predicted membrane protein [Function unknown]; Region: COG1511 521095001645 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521095001646 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521095001647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521095001648 Helix-turn-helix domains; Region: HTH; cl00088 521095001649 S-adenosylmethionine synthetase; Validated; Region: PRK05250 521095001650 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521095001651 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521095001652 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521095001653 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 521095001654 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 521095001655 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 521095001656 putative L-serine binding site [chemical binding]; other site 521095001657 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 521095001658 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 521095001659 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521095001660 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521095001661 HIGH motif; other site 521095001662 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521095001663 active site 521095001664 KMSKS motif; other site 521095001665 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 521095001666 active site 521095001667 catalytic site [active] 521095001668 substrate binding site [chemical binding]; other site 521095001669 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 521095001670 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521095001671 active site 521095001672 metal binding site [ion binding]; metal-binding site 521095001673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 521095001674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001676 Walker A/P-loop; other site 521095001677 ATP binding site [chemical binding]; other site 521095001678 ABC transporter signature motif; other site 521095001679 Walker B; other site 521095001680 D-loop; other site 521095001681 H-loop/switch region; other site 521095001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521095001683 putative substrate translocation pore; other site 521095001684 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 521095001685 Uncharacterized conserved protein [Function unknown]; Region: COG2461 521095001686 Family of unknown function (DUF438); Region: DUF438; pfam04282 521095001687 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 521095001688 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521095001689 RelB antitoxin; Region: RelB; cl01171 521095001690 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521095001691 putative catalytic site [active] 521095001692 putative metal binding site [ion binding]; other site 521095001693 putative phosphate binding site [ion binding]; other site 521095001694 aspartate aminotransferase; Provisional; Region: PRK05764 521095001695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095001696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001697 homodimer interface [polypeptide binding]; other site 521095001698 catalytic residue [active] 521095001699 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 521095001700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 521095001701 active site 521095001702 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095001703 substrate binding site [chemical binding]; other site 521095001704 catalytic residues [active] 521095001705 dimer interface [polypeptide binding]; other site 521095001706 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521095001707 dihydrodipicolinate synthase; Region: dapA; TIGR00674 521095001708 dimer interface [polypeptide binding]; other site 521095001709 active site 521095001710 catalytic residue [active] 521095001711 dihydrodipicolinate reductase; Provisional; Region: PRK00048 521095001712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095001713 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 521095001714 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 521095001715 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 521095001716 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 521095001717 trimer interface [polypeptide binding]; other site 521095001718 active site 521095001719 substrate binding site [chemical binding]; other site 521095001720 CoA binding site [chemical binding]; other site 521095001721 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 521095001722 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 521095001723 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521095001724 DHH family; Region: DHH; pfam01368 521095001725 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521095001726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095001727 ATP binding site [chemical binding]; other site 521095001728 putative Mg++ binding site [ion binding]; other site 521095001729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095001730 nucleotide binding region [chemical binding]; other site 521095001731 ATP-binding site [chemical binding]; other site 521095001732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 521095001733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095001734 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521095001735 synthetase active site [active] 521095001736 NTP binding site [chemical binding]; other site 521095001737 metal binding site [ion binding]; metal-binding site 521095001738 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521095001739 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 521095001740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095001741 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 521095001742 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521095001743 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521095001744 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 521095001745 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521095001746 23S rRNA binding site [nucleotide binding]; other site 521095001747 L21 binding site [polypeptide binding]; other site 521095001748 L13 binding site [polypeptide binding]; other site 521095001749 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 521095001750 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 521095001751 Mg++ binding site [ion binding]; other site 521095001752 putative catalytic motif [active] 521095001753 substrate binding site [chemical binding]; other site 521095001754 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 521095001755 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 521095001756 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 521095001757 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 521095001758 active site 521095001759 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 521095001760 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 521095001761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095001762 active site 521095001763 HIGH motif; other site 521095001764 nucleotide binding site [chemical binding]; other site 521095001765 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521095001766 KMSK motif region; other site 521095001767 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 521095001768 tRNA binding surface [nucleotide binding]; other site 521095001769 anticodon binding site; other site 521095001770 Helix-turn-helix domains; Region: HTH; cl00088 521095001771 Helix-turn-helix domains; Region: HTH; cl00088 521095001772 transcription termination factor Rho; Provisional; Region: rho; PRK09376 521095001773 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 521095001774 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095001775 RNA binding site [nucleotide binding]; other site 521095001776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001777 Walker A motif; other site 521095001778 ATP binding site [chemical binding]; other site 521095001779 Walker B motif; other site 521095001780 NMT1-like family; Region: NMT1_2; cl15260 521095001781 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 521095001782 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 521095001783 putative ligand binding site [chemical binding]; other site 521095001784 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 521095001785 TM-ABC transporter signature motif; other site 521095001786 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 521095001787 TM-ABC transporter signature motif; other site 521095001788 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 521095001789 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 521095001790 Walker A/P-loop; other site 521095001791 ATP binding site [chemical binding]; other site 521095001792 Q-loop/lid; other site 521095001793 ABC transporter signature motif; other site 521095001794 Walker B; other site 521095001795 D-loop; other site 521095001796 H-loop/switch region; other site 521095001797 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 521095001798 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 521095001799 Walker A/P-loop; other site 521095001800 ATP binding site [chemical binding]; other site 521095001801 Q-loop/lid; other site 521095001802 ABC transporter signature motif; other site 521095001803 Walker B; other site 521095001804 D-loop; other site 521095001805 H-loop/switch region; other site 521095001806 homoserine kinase; Provisional; Region: PRK01212 521095001807 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521095001808 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521095001809 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 521095001810 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 521095001811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001812 catalytic residue [active] 521095001813 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 521095001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095001815 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521095001816 aspartate kinase; Reviewed; Region: PRK09034 521095001817 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521095001818 nucleotide binding site [chemical binding]; other site 521095001819 substrate binding site [chemical binding]; other site 521095001820 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521095001821 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521095001822 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 521095001823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095001824 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 521095001825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 521095001826 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 521095001827 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 521095001828 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 521095001829 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 521095001830 Int/Topo IB signature motif; other site 521095001831 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521095001832 active site 521095001833 substrate binding site [chemical binding]; other site 521095001834 catalytic site [active] 521095001835 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 521095001836 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 521095001837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001838 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 521095001839 non-specific DNA binding site [nucleotide binding]; other site 521095001840 salt bridge; other site 521095001841 sequence-specific DNA binding site [nucleotide binding]; other site 521095001842 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521095001843 Catalytic site [active] 521095001844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001845 non-specific DNA binding site [nucleotide binding]; other site 521095001846 salt bridge; other site 521095001847 sequence-specific DNA binding site [nucleotide binding]; other site 521095001848 BRO family, N-terminal domain; Region: Bro-N; cl10591 521095001849 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 521095001850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095001851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095001852 S-adenosylmethionine binding site [chemical binding]; other site 521095001853 TIR domain; Region: TIR_2; cl15770 521095001854 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 521095001855 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 521095001856 Int/Topo IB signature motif; other site 521095001857 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521095001858 dimer interface [polypeptide binding]; other site 521095001859 ssDNA binding site [nucleotide binding]; other site 521095001860 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521095001861 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 521095001862 AAA domain; Region: AAA_22; pfam13401 521095001863 Phage Terminase; Region: Terminase_1; pfam03354 521095001864 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 521095001865 Phage capsid family; Region: Phage_capsid; pfam05065 521095001866 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 521095001867 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 521095001868 tape measure domain; Region: tape_meas_nterm; TIGR02675 521095001869 Phage-related protein [Function unknown]; Region: COG5412 521095001870 Bacteriophage holin; Region: Phage_holin_1; cl02344 521095001871 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 521095001872 amidase catalytic site [active] 521095001873 Zn binding residues [ion binding]; other site 521095001874 substrate binding site [chemical binding]; other site 521095001875 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095001876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 521095001877 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 521095001878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095001879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001880 homodimer interface [polypeptide binding]; other site 521095001881 catalytic residue [active] 521095001882 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095001883 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095001884 putative substrate binding site [chemical binding]; other site 521095001885 putative ATP binding site [chemical binding]; other site 521095001886 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 521095001887 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521095001888 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 521095001889 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 521095001890 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 521095001891 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 521095001892 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 521095001893 ABC-2 type transporter; Region: ABC2_membrane; cl11417 521095001894 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 521095001895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095001896 DNA-binding site [nucleotide binding]; DNA binding site 521095001897 UTRA domain; Region: UTRA; cl01230 521095001898 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521095001899 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 521095001900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001901 dimer interface [polypeptide binding]; other site 521095001902 conserved gate region; other site 521095001903 putative PBP binding loops; other site 521095001904 ABC-ATPase subunit interface; other site 521095001905 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521095001906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001907 dimer interface [polypeptide binding]; other site 521095001908 conserved gate region; other site 521095001909 putative PBP binding loops; other site 521095001910 ABC-ATPase subunit interface; other site 521095001911 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 521095001912 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 521095001913 Walker A/P-loop; other site 521095001914 ATP binding site [chemical binding]; other site 521095001915 Q-loop/lid; other site 521095001916 ABC transporter signature motif; other site 521095001917 Walker B; other site 521095001918 D-loop; other site 521095001919 H-loop/switch region; other site 521095001920 TOBE domain; Region: TOBE_2; cl01440 521095001921 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 521095001922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521095001923 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 521095001924 glutamate dehydrogenase; Provisional; Region: PRK09414 521095001925 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521095001926 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 521095001927 NAD(P) binding site [chemical binding]; other site 521095001928 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 521095001929 active site 521095001930 DNA binding site [nucleotide binding] 521095001931 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 521095001932 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 521095001933 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 521095001934 catalytic site [active] 521095001935 subunit interface [polypeptide binding]; other site 521095001936 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 521095001937 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521095001938 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521095001939 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 521095001940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521095001941 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521095001942 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 521095001943 IMP binding site; other site 521095001944 dimer interface [polypeptide binding]; other site 521095001945 partial ornithine binding site; other site 521095001946 trigger factor; Region: tig; TIGR00115 521095001947 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 521095001948 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521095001949 Clp protease; Region: CLP_protease; pfam00574 521095001950 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521095001951 oligomer interface [polypeptide binding]; other site 521095001952 active site residues [active] 521095001953 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521095001954 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 521095001955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095001956 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 521095001957 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 521095001958 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 521095001959 Ligand binding site; other site 521095001960 metal-binding site 521095001961 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095001962 active site 521095001963 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 521095001964 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 521095001965 putative ATP binding site [chemical binding]; other site 521095001966 putative substrate interface [chemical binding]; other site 521095001967 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521095001968 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095001969 active site 521095001970 HIGH motif; other site 521095001971 nucleotide binding site [chemical binding]; other site 521095001972 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095001973 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521095001974 active site 521095001975 KMSKS motif; other site 521095001976 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521095001977 tRNA binding surface [nucleotide binding]; other site 521095001978 anticodon binding site; other site 521095001979 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521095001980 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 521095001981 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 521095001982 Potassium binding sites [ion binding]; other site 521095001983 Cesium cation binding sites [ion binding]; other site 521095001984 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 521095001985 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521095001986 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521095001987 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521095001988 homodimer interface [polypeptide binding]; other site 521095001989 NADP binding site [chemical binding]; other site 521095001990 substrate binding site [chemical binding]; other site 521095001991 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 521095001992 homodecamer interface [polypeptide binding]; other site 521095001993 GTP cyclohydrolase I; Provisional; Region: PLN03044 521095001994 active site 521095001995 putative catalytic site residues [active] 521095001996 zinc binding site [ion binding]; other site 521095001997 GTP-CH-I/GFRP interaction surface; other site 521095001998 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521095001999 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095002000 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095002001 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 521095002002 Double zinc ribbon; Region: DZR; pfam12773 521095002003 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 521095002004 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 521095002005 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521095002006 active site 521095002007 dimer interface [polypeptide binding]; other site 521095002008 motif 1; other site 521095002009 motif 2; other site 521095002010 motif 3; other site 521095002011 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 521095002012 anticodon binding site; other site 521095002013 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 521095002014 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 521095002015 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 521095002016 putative catalytic cysteine [active] 521095002017 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 521095002018 putative active site [active] 521095002019 metal binding site [ion binding]; metal-binding site 521095002020 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 521095002021 folate binding site [chemical binding]; other site 521095002022 NADP+ binding site [chemical binding]; other site 521095002023 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 521095002024 dimerization interface [polypeptide binding]; other site 521095002025 active site 521095002026 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 521095002027 active site 521095002028 8-oxo-dGMP binding site [chemical binding]; other site 521095002029 nudix motif; other site 521095002030 metal binding site [ion binding]; metal-binding site 521095002031 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521095002032 active site 521095002033 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 521095002034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095002035 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 521095002036 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 521095002037 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 521095002038 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 521095002039 putative active site [active] 521095002040 catalytic site [active] 521095002041 putative substrate binding site [chemical binding]; other site 521095002042 HRDC domain; Region: HRDC; cl02578 521095002043 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 521095002044 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 521095002045 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 521095002046 generic binding surface I; other site 521095002047 generic binding surface II; other site 521095002048 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 521095002049 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521095002050 nucleotide binding site/active site [active] 521095002051 HIT family signature motif; other site 521095002052 catalytic residue [active] 521095002053 Acetokinase family; Region: Acetate_kinase; cl01029 521095002054 propionate/acetate kinase; Provisional; Region: PRK12379 521095002055 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 521095002056 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 521095002057 active site 521095002058 catalytic residues [active] 521095002059 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 521095002060 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 521095002061 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 521095002062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002063 UDP-galactopyranose mutase; Region: GLF; pfam03275 521095002064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521095002065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095002066 active site 521095002067 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 521095002068 Maf-like protein; Region: Maf; pfam02545 521095002069 active site 521095002070 dimer interface [polypeptide binding]; other site 521095002071 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 521095002072 TRAM domain; Region: TRAM; cl01282 521095002073 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 521095002074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002075 S-adenosylmethionine binding site [chemical binding]; other site 521095002076 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521095002077 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521095002078 active site 521095002079 HIGH motif; other site 521095002080 dimer interface [polypeptide binding]; other site 521095002081 KMSKS motif; other site 521095002082 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 521095002083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002084 FeS/SAM binding site; other site 521095002085 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095002086 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 521095002087 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095002088 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 521095002089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095002090 active site turn [active] 521095002091 phosphorylation site [posttranslational modification] 521095002092 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 521095002093 trimer interface [polypeptide binding]; other site 521095002094 active site 521095002095 dimer interface [polypeptide binding]; other site 521095002096 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 521095002097 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 521095002098 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 521095002099 shikimate binding site; other site 521095002100 NAD(P) binding site [chemical binding]; other site 521095002101 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 521095002102 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521095002103 ADP binding site [chemical binding]; other site 521095002104 magnesium binding site [ion binding]; other site 521095002105 putative shikimate binding site; other site 521095002106 Chorismate mutase type II; Region: CM_2; cl00693 521095002107 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 521095002108 Tetramer interface [polypeptide binding]; other site 521095002109 active site 521095002110 FMN-binding site [chemical binding]; other site 521095002111 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 521095002112 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 521095002113 hinge; other site 521095002114 active site 521095002115 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521095002116 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521095002117 active site 521095002118 intersubunit interface [polypeptide binding]; other site 521095002119 catalytic residue [active] 521095002120 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 521095002121 active site 521095002122 dimer interface [polypeptide binding]; other site 521095002123 metal binding site [ion binding]; metal-binding site 521095002124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095002125 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 521095002126 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095002127 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095002128 Double zinc ribbon; Region: DZR; pfam12773 521095002129 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 521095002130 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 521095002131 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521095002132 active site 521095002133 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521095002134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095002135 binding surface 521095002136 TPR motif; other site 521095002137 rod shape-determining protein MreB; Provisional; Region: PRK13927 521095002138 Cell division protein FtsA; Region: FtsA; cl11496 521095002139 rod shape-determining protein MreC; Provisional; Region: PRK13922 521095002140 rod shape-determining protein MreC; Region: MreC; pfam04085 521095002141 rod shape-determining protein MreD; Region: MreD; cl01087 521095002142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521095002143 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095002144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095002145 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521095002146 Domain of unknown function (DUF697); Region: DUF697; cl12064 521095002147 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 521095002148 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 521095002149 B12 binding site [chemical binding]; other site 521095002150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002151 FeS/SAM binding site; other site 521095002152 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 521095002153 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 521095002154 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 521095002155 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095002156 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095002157 Walker A/P-loop; other site 521095002158 ATP binding site [chemical binding]; other site 521095002159 Q-loop/lid; other site 521095002160 ABC transporter signature motif; other site 521095002161 Walker B; other site 521095002162 D-loop; other site 521095002163 H-loop/switch region; other site 521095002164 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095002165 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095002166 Walker A/P-loop; other site 521095002167 ATP binding site [chemical binding]; other site 521095002168 Q-loop/lid; other site 521095002169 ABC transporter signature motif; other site 521095002170 Walker B; other site 521095002171 D-loop; other site 521095002172 H-loop/switch region; other site 521095002173 Cobalt transport protein; Region: CbiQ; cl00463 521095002174 GTPase CgtA; Reviewed; Region: obgE; PRK12297 521095002175 GTP1/OBG; Region: GTP1_OBG; pfam01018 521095002176 Obg GTPase; Region: Obg; cd01898 521095002177 G1 box; other site 521095002178 GTP/Mg2+ binding site [chemical binding]; other site 521095002179 Switch I region; other site 521095002180 G2 box; other site 521095002181 G3 box; other site 521095002182 Switch II region; other site 521095002183 G4 box; other site 521095002184 G5 box; other site 521095002185 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 521095002186 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 521095002187 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521095002188 active site 521095002189 (T/H)XGH motif; other site 521095002190 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 521095002191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095002192 Oligomerisation domain; Region: Oligomerisation; cl00519 521095002193 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 521095002194 active site 521095002195 DNA polymerase IV; Validated; Region: PRK02406 521095002196 DNA binding site [nucleotide binding] 521095002197 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 521095002198 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 521095002199 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 521095002200 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 521095002201 RimM N-terminal domain; Region: RimM; pfam01782 521095002202 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 521095002203 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521095002204 Catalytic site [active] 521095002205 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 521095002206 dimer interface [polypeptide binding]; other site 521095002207 motif 1; other site 521095002208 active site 521095002209 motif 2; other site 521095002210 motif 3; other site 521095002211 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 521095002212 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095002213 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 521095002214 pyruvate phosphate dikinase; Provisional; Region: PRK09279 521095002215 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 521095002216 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 521095002217 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 521095002218 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 521095002219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095002220 Zn2+ binding site [ion binding]; other site 521095002221 Mg2+ binding site [ion binding]; other site 521095002222 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 521095002223 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 521095002224 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521095002225 RNA/DNA hybrid binding site [nucleotide binding]; other site 521095002226 active site 521095002227 Restriction endonuclease; Region: Mrr_cat; cl00516 521095002228 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521095002229 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 521095002230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002231 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521095002232 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 521095002233 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 521095002234 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 521095002235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002236 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 521095002237 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521095002238 Int/Topo IB signature motif; other site 521095002239 active site 521095002240 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521095002241 rRNA interaction site [nucleotide binding]; other site 521095002242 S8 interaction site; other site 521095002243 putative laminin-1 binding site; other site 521095002244 elongation factor Ts; Provisional; Region: tsf; PRK09377 521095002245 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 521095002246 Elongation factor TS; Region: EF_TS; pfam00889 521095002247 Elongation factor TS; Region: EF_TS; pfam00889 521095002248 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 521095002249 putative nucleotide binding site [chemical binding]; other site 521095002250 uridine monophosphate binding site [chemical binding]; other site 521095002251 homohexameric interface [polypeptide binding]; other site 521095002252 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521095002253 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 521095002254 hinge region; other site 521095002255 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521095002256 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 521095002257 catalytic residue [active] 521095002258 putative FPP diphosphate binding site; other site 521095002259 putative FPP binding hydrophobic cleft; other site 521095002260 dimer interface [polypeptide binding]; other site 521095002261 putative IPP diphosphate binding site; other site 521095002262 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 521095002263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 521095002264 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 521095002265 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 521095002266 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 521095002267 RIP metalloprotease RseP; Region: TIGR00054 521095002268 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002269 active site 521095002270 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002271 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521095002272 protein binding site [polypeptide binding]; other site 521095002273 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002274 putative substrate binding region [chemical binding]; other site 521095002275 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521095002276 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 521095002277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521095002278 prolyl-tRNA synthetase; Provisional; Region: PRK09194 521095002279 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 521095002280 dimer interface [polypeptide binding]; other site 521095002281 motif 1; other site 521095002282 active site 521095002283 motif 2; other site 521095002284 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 521095002285 putative deacylase active site [active] 521095002286 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 521095002287 active site 521095002288 motif 3; other site 521095002289 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 521095002290 anticodon binding site; other site 521095002291 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 521095002292 ZIP Zinc transporter; Region: Zip; pfam02535 521095002293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521095002294 active site 521095002295 metal binding site [ion binding]; metal-binding site 521095002296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095002297 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095002298 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095002299 ABC transporter; Region: ABC_tran_2; pfam12848 521095002300 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095002301 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 521095002302 active site 521095002303 putative substrate binding region [chemical binding]; other site 521095002304 ScpA/B protein; Region: ScpA_ScpB; cl00598 521095002305 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 521095002306 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521095002307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095002308 RNA binding surface [nucleotide binding]; other site 521095002309 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 521095002310 active site 521095002311 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095002312 catalytic core [active] 521095002313 cytidylate kinase; Provisional; Region: cmk; PRK00023 521095002314 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521095002315 CMP-binding site; other site 521095002316 The sites determining sugar specificity; other site 521095002317 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521095002318 putative acyl-acceptor binding pocket; other site 521095002319 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 521095002320 LytB protein; Region: LYTB; cl00507 521095002321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521095002322 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 521095002323 Protein of unknown function (DUF512); Region: DUF512; pfam04459 521095002324 GTP-binding protein Der; Reviewed; Region: PRK00093 521095002325 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521095002326 G1 box; other site 521095002327 GTP/Mg2+ binding site [chemical binding]; other site 521095002328 Switch I region; other site 521095002329 G2 box; other site 521095002330 Switch II region; other site 521095002331 G3 box; other site 521095002332 G4 box; other site 521095002333 G5 box; other site 521095002334 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521095002335 G1 box; other site 521095002336 GTP/Mg2+ binding site [chemical binding]; other site 521095002337 Switch I region; other site 521095002338 G2 box; other site 521095002339 G3 box; other site 521095002340 Switch II region; other site 521095002341 G4 box; other site 521095002342 G5 box; other site 521095002343 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 521095002344 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521095002345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002346 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521095002347 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 521095002348 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 521095002349 substrate binding site [chemical binding]; other site 521095002350 hexamer interface [polypeptide binding]; other site 521095002351 metal binding site [ion binding]; metal-binding site 521095002352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521095002353 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 521095002354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095002355 catalytic residue [active] 521095002356 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521095002357 Putative zinc ribbon domain; Region: DUF164; pfam02591 521095002358 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 521095002359 Flavoprotein; Region: Flavoprotein; cl08021 521095002360 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 521095002361 endonuclease IV; Provisional; Region: PRK01060 521095002362 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 521095002363 AP (apurinic/apyrimidinic) site pocket; other site 521095002364 DNA interaction; other site 521095002365 Metal-binding active site; metal-binding site 521095002366 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095002367 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095002368 ABC transporter; Region: ABC_tran_2; pfam12848 521095002369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 521095002370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002371 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095002372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002373 Walker A/P-loop; other site 521095002374 ATP binding site [chemical binding]; other site 521095002375 Q-loop/lid; other site 521095002376 ABC transporter signature motif; other site 521095002377 Walker B; other site 521095002378 D-loop; other site 521095002379 H-loop/switch region; other site 521095002380 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095002381 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002382 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 521095002383 Walker A/P-loop; other site 521095002384 ATP binding site [chemical binding]; other site 521095002385 Q-loop/lid; other site 521095002386 ABC transporter signature motif; other site 521095002387 Walker B; other site 521095002388 D-loop; other site 521095002389 H-loop/switch region; other site 521095002390 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 521095002391 DNA binding site [nucleotide binding] 521095002392 active site 521095002393 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 521095002394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521095002395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521095002396 ligand binding site [chemical binding]; other site 521095002397 Helix-turn-helix domains; Region: HTH; cl00088 521095002398 hybrid cluster protein; Provisional; Region: PRK05290 521095002399 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 521095002400 hybrid metal cluster; other site 521095002401 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 521095002402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095002403 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521095002404 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521095002405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002406 S-adenosylmethionine binding site [chemical binding]; other site 521095002407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002409 S-adenosylmethionine binding site [chemical binding]; other site 521095002410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002411 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 521095002412 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095002413 active site 521095002414 motif I; other site 521095002415 motif II; other site 521095002416 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095002417 hypothetical protein; Provisional; Region: PRK08262 521095002418 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521095002419 metal binding site [ion binding]; metal-binding site 521095002420 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521095002421 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 521095002422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095002423 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 521095002424 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521095002425 homotrimer interaction site [polypeptide binding]; other site 521095002426 putative active site [active] 521095002427 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095002428 phosphopeptide binding site; other site 521095002429 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 521095002430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521095002431 DNA binding residues [nucleotide binding] 521095002432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095002433 active site 521095002434 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 521095002435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521095002436 NlpC/P60 family; Region: NLPC_P60; cl11438 521095002437 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 521095002438 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 521095002439 Cl- selectivity filter; other site 521095002440 Cl- binding residues [ion binding]; other site 521095002441 pore gating glutamate residue; other site 521095002442 dimer interface [polypeptide binding]; other site 521095002443 H+/Cl- coupling transport residue; other site 521095002444 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 521095002445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002446 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 521095002447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 521095002448 putative metal binding site [ion binding]; other site 521095002449 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521095002450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002451 S-adenosylmethionine binding site [chemical binding]; other site 521095002452 Leucine carboxyl methyltransferase; Region: LCM; cl01306 521095002453 Predicted acetyltransferase [General function prediction only]; Region: COG3981 521095002454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095002455 Coenzyme A binding pocket [chemical binding]; other site 521095002456 A new structural DNA glycosylase; Region: AlkD_like; cd06561 521095002457 active site 521095002458 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521095002459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095002461 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521095002462 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521095002463 trimer interface [polypeptide binding]; other site 521095002464 active site 521095002465 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 521095002466 ATP cone domain; Region: ATP-cone; pfam03477 521095002467 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 521095002468 putative peptidoglycan binding site; other site 521095002469 LexA repressor; Validated; Region: PRK00215 521095002470 Helix-turn-helix domains; Region: HTH; cl00088 521095002471 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521095002472 Catalytic site [active] 521095002473 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 521095002474 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 521095002475 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 521095002476 HflX GTPase family; Region: HflX; cd01878 521095002477 G1 box; other site 521095002478 GTP/Mg2+ binding site [chemical binding]; other site 521095002479 Switch I region; other site 521095002480 G2 box; other site 521095002481 G3 box; other site 521095002482 Switch II region; other site 521095002483 G4 box; other site 521095002484 G5 box; other site 521095002485 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521095002486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002487 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 521095002488 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002490 FeS/SAM binding site; other site 521095002491 TRAM domain; Region: TRAM; cl01282 521095002492 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 521095002493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095002494 ATP binding site [chemical binding]; other site 521095002495 Mg2+ binding site [ion binding]; other site 521095002496 G-X-G motif; other site 521095002497 phosphodiesterase; Provisional; Region: PRK12704 521095002498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 521095002499 RecX family; Region: RecX; cl00936 521095002500 recombinase A; Provisional; Region: recA; PRK09354 521095002501 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521095002502 hexamer interface [polypeptide binding]; other site 521095002503 Walker A motif; other site 521095002504 ATP binding site [chemical binding]; other site 521095002505 Walker B motif; other site 521095002506 Competence-damaged protein; Region: CinA; cl00666 521095002507 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521095002508 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 521095002509 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002511 FeS/SAM binding site; other site 521095002512 Protein of unknown function (DUF520); Region: DUF520; cl00723 521095002513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 521095002514 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 521095002515 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 521095002516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002517 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 521095002518 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 521095002519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095002520 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 521095002521 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 521095002522 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521095002523 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521095002524 RNase E interface [polypeptide binding]; other site 521095002525 trimer interface [polypeptide binding]; other site 521095002526 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521095002527 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521095002528 RNase E interface [polypeptide binding]; other site 521095002529 trimer interface [polypeptide binding]; other site 521095002530 active site 521095002531 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521095002532 putative nucleic acid binding region [nucleotide binding]; other site 521095002533 G-X-X-G motif; other site 521095002534 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521095002535 RNA binding site [nucleotide binding]; other site 521095002536 domain interface; other site 521095002537 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521095002538 16S/18S rRNA binding site [nucleotide binding]; other site 521095002539 S13e-L30e interaction site [polypeptide binding]; other site 521095002540 25S rRNA binding site [nucleotide binding]; other site 521095002541 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 521095002542 Recombination protein O N terminal; Region: RecO_N; cl15812 521095002543 Recombination protein O C terminal; Region: RecO_C; pfam02565 521095002544 GTPase Era; Reviewed; Region: era; PRK00089 521095002545 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521095002546 G1 box; other site 521095002547 GTP/Mg2+ binding site [chemical binding]; other site 521095002548 Switch I region; other site 521095002549 G2 box; other site 521095002550 Switch II region; other site 521095002551 G3 box; other site 521095002552 G4 box; other site 521095002553 G5 box; other site 521095002554 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 521095002555 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 521095002556 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 521095002557 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 521095002558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002559 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002560 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 521095002561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002562 FeS/SAM binding site; other site 521095002563 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 521095002564 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095002565 HSP70 interaction site [polypeptide binding]; other site 521095002566 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 521095002567 substrate binding site [polypeptide binding]; other site 521095002568 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521095002569 Zn binding sites [ion binding]; other site 521095002570 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521095002571 dimer interface [polypeptide binding]; other site 521095002572 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095002573 HSP70 interaction site [polypeptide binding]; other site 521095002574 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 521095002575 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521095002576 Zn binding sites [ion binding]; other site 521095002577 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 521095002578 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 521095002579 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 521095002580 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 521095002581 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521095002582 FMN binding site [chemical binding]; other site 521095002583 active site 521095002584 catalytic residues [active] 521095002585 substrate binding site [chemical binding]; other site 521095002586 GTP-binding protein LepA; Provisional; Region: PRK05433 521095002587 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521095002588 G1 box; other site 521095002589 putative GEF interaction site [polypeptide binding]; other site 521095002590 GTP/Mg2+ binding site [chemical binding]; other site 521095002591 Switch I region; other site 521095002592 G2 box; other site 521095002593 G3 box; other site 521095002594 Switch II region; other site 521095002595 G4 box; other site 521095002596 G5 box; other site 521095002597 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521095002598 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521095002599 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521095002600 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 521095002601 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 521095002602 DNA polymerase III, delta subunit; Region: holA; TIGR01128 521095002603 Competence protein; Region: Competence; cl00471 521095002604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095002605 SLBB domain; Region: SLBB; pfam10531 521095002606 comEA protein; Region: comE; TIGR01259 521095002607 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 521095002608 THUMP domain; Region: THUMP; cl12076 521095002609 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 521095002610 Ligand Binding Site [chemical binding]; other site 521095002611 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 521095002612 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 521095002613 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 521095002614 catalytic site [active] 521095002615 G-X2-G-X-G-K; other site 521095002616 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 521095002617 active site 521095002618 dimer interface [polypeptide binding]; other site 521095002619 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 521095002620 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 521095002621 heterodimer interface [polypeptide binding]; other site 521095002622 active site 521095002623 FMN binding site [chemical binding]; other site 521095002624 homodimer interface [polypeptide binding]; other site 521095002625 substrate binding site [chemical binding]; other site 521095002626 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 521095002627 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 521095002628 FAD binding pocket [chemical binding]; other site 521095002629 FAD binding motif [chemical binding]; other site 521095002630 phosphate binding motif [ion binding]; other site 521095002631 beta-alpha-beta structure motif; other site 521095002632 NAD binding pocket [chemical binding]; other site 521095002633 Iron coordination center [ion binding]; other site 521095002634 dihydroorotase; Validated; Region: pyrC; PRK09357 521095002635 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095002636 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 521095002637 active site 521095002638 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 521095002639 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521095002640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095002641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095002642 active site 521095002643 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 521095002644 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 521095002645 Walker A/P-loop; other site 521095002646 ATP binding site [chemical binding]; other site 521095002647 Q-loop/lid; other site 521095002648 ABC transporter signature motif; other site 521095002649 Walker B; other site 521095002650 D-loop; other site 521095002651 H-loop/switch region; other site 521095002652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095002653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095002654 DNA binding site [nucleotide binding] 521095002655 domain linker motif; other site 521095002656 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 521095002657 ligand binding site [chemical binding]; other site 521095002658 dimerization interface (open form) [polypeptide binding]; other site 521095002659 dimerization interface (closed form) [polypeptide binding]; other site 521095002660 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 521095002661 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 521095002662 active site 521095002663 catalytic residues [active] 521095002664 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 521095002665 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 521095002666 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521095002667 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 521095002668 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521095002669 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521095002670 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 521095002671 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521095002672 TM-ABC transporter signature motif; other site 521095002673 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 521095002674 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 521095002675 Walker A/P-loop; other site 521095002676 ATP binding site [chemical binding]; other site 521095002677 Q-loop/lid; other site 521095002678 ABC transporter signature motif; other site 521095002679 Walker B; other site 521095002680 D-loop; other site 521095002681 H-loop/switch region; other site 521095002682 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 521095002683 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521095002684 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 521095002685 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521095002686 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 521095002687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521095002688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521095002689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521095002690 DNA binding residues [nucleotide binding] 521095002691 DNA primase, catalytic core; Region: dnaG; TIGR01391 521095002692 CHC2 zinc finger; Region: zf-CHC2; cl15369 521095002693 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521095002694 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521095002695 active site 521095002696 metal binding site [ion binding]; metal-binding site 521095002697 interdomain interaction site; other site 521095002698 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 521095002699 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 521095002700 active site 521095002701 Riboflavin kinase; Region: Flavokinase; cl03312 521095002702 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 521095002703 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 521095002704 RNA binding site [nucleotide binding]; other site 521095002705 active site 521095002706 DHH family; Region: DHH; pfam01368 521095002707 Ribosome-binding factor A; Region: RBFA; cl00542 521095002708 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521095002709 translation initiation factor IF-2; Region: IF-2; TIGR00487 521095002710 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521095002711 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521095002712 G1 box; other site 521095002713 putative GEF interaction site [polypeptide binding]; other site 521095002714 GTP/Mg2+ binding site [chemical binding]; other site 521095002715 Switch I region; other site 521095002716 G2 box; other site 521095002717 G3 box; other site 521095002718 Switch II region; other site 521095002719 G4 box; other site 521095002720 G5 box; other site 521095002721 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521095002722 Translation-initiation factor 2; Region: IF-2; pfam11987 521095002723 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521095002724 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 521095002725 NusA N-terminal domain; Region: NusA_N; pfam08529 521095002726 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521095002727 RNA binding site [nucleotide binding]; other site 521095002728 homodimer interface [polypeptide binding]; other site 521095002729 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 521095002730 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521095002731 G-X-X-G motif; other site 521095002732 ribosome maturation protein RimP; Reviewed; Region: PRK00092 521095002733 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 521095002734 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 521095002735 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 521095002736 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521095002737 HIGH motif; other site 521095002738 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095002739 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521095002740 active site 521095002741 KMSKS motif; other site 521095002742 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521095002743 tRNA binding surface [nucleotide binding]; other site 521095002744 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 521095002745 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 521095002746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602 521095002747 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 521095002748 active site 521095002749 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521095002750 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 521095002751 DXD motif; other site 521095002752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002753 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095002754 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 521095002755 Walker A/P-loop; other site 521095002756 ATP binding site [chemical binding]; other site 521095002757 Q-loop/lid; other site 521095002758 ABC transporter signature motif; other site 521095002759 Walker B; other site 521095002760 D-loop; other site 521095002761 H-loop/switch region; other site 521095002762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002763 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 521095002764 Walker A/P-loop; other site 521095002765 ATP binding site [chemical binding]; other site 521095002766 Q-loop/lid; other site 521095002767 ABC transporter signature motif; other site 521095002768 Walker B; other site 521095002769 D-loop; other site 521095002770 H-loop/switch region; other site 521095002771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521095002772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095002773 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521095002774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095002775 RNA binding surface [nucleotide binding]; other site 521095002776 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 521095002777 active site 521095002778 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 521095002779 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 521095002780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095002781 active site 521095002782 HIGH motif; other site 521095002783 nucleotide binding site [chemical binding]; other site 521095002784 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095002785 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521095002786 active site 521095002787 KMSKS motif; other site 521095002788 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 521095002789 tRNA binding surface [nucleotide binding]; other site 521095002790 anticodon binding site; other site 521095002791 FtsH Extracellular; Region: FtsH_ext; pfam06480 521095002792 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521095002793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095002795 Walker A motif; other site 521095002796 ATP binding site [chemical binding]; other site 521095002797 Walker B motif; other site 521095002798 arginine finger; other site 521095002799 Peptidase family M41; Region: Peptidase_M41; pfam01434 521095002800 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521095002801 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 521095002802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095002803 non-specific DNA binding site [nucleotide binding]; other site 521095002804 salt bridge; other site 521095002805 sequence-specific DNA binding site [nucleotide binding]; other site 521095002806 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 521095002807 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521095002808 OpgC protein; Region: OpgC_C; cl00792 521095002809 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 521095002810 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 521095002811 Protein of unknown function (DUF454); Region: DUF454; cl01063 521095002812 signal recognition particle protein; Provisional; Region: PRK10867 521095002813 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 521095002814 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521095002815 P loop; other site 521095002816 GTP binding site [chemical binding]; other site 521095002817 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521095002818 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 521095002819 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 521095002820 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521095002821 P loop; other site 521095002822 GTP binding site [chemical binding]; other site 521095002823 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521095002824 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 521095002825 Walker A/P-loop; other site 521095002826 ATP binding site [chemical binding]; other site 521095002827 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 521095002828 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 521095002829 Q-loop/lid; other site 521095002830 ABC transporter signature motif; other site 521095002831 Walker B; other site 521095002832 D-loop; other site 521095002833 H-loop/switch region; other site 521095002834 ribonuclease III; Reviewed; Region: rnc; PRK00102 521095002835 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521095002836 dimerization interface [polypeptide binding]; other site 521095002837 active site 521095002838 metal binding site [ion binding]; metal-binding site 521095002839 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521095002840 dsRNA binding site [nucleotide binding]; other site 521095002841 Phosphopantetheine attachment site; Region: PP-binding; cl09936 521095002842 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 521095002843 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 521095002844 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 521095002845 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521095002846 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 521095002847 active site 521095002848 (T/H)XGH motif; other site 521095002849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002850 S-adenosylmethionine binding site [chemical binding]; other site 521095002851 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 521095002852 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 521095002853 generic binding surface II; other site 521095002854 ssDNA binding site; other site 521095002855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095002856 ATP binding site [chemical binding]; other site 521095002857 putative Mg++ binding site [ion binding]; other site 521095002858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095002859 nucleotide binding region [chemical binding]; other site 521095002860 ATP-binding site [chemical binding]; other site 521095002861 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 521095002862 DAK2 domain; Region: Dak2; cl03685 521095002863 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 521095002864 Asp23 family; Region: Asp23; cl00574 521095002865 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 521095002866 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 521095002867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095002868 motif II; other site 521095002869 Thiamine pyrophosphokinase; Region: TPK; cd07995 521095002870 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 521095002871 active site 521095002872 dimerization interface [polypeptide binding]; other site 521095002873 thiamine binding site [chemical binding]; other site 521095002874 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 521095002875 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 521095002876 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 521095002877 putative RNA binding site [nucleotide binding]; other site 521095002878 16S rRNA methyltransferase B; Provisional; Region: PRK14902 521095002879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 521095002880 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 521095002881 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521095002882 putative active site [active] 521095002883 substrate binding site [chemical binding]; other site 521095002884 putative cosubstrate binding site; other site 521095002885 catalytic site [active] 521095002886 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521095002887 substrate binding site [chemical binding]; other site 521095002888 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521095002889 active site 521095002890 catalytic residues [active] 521095002891 metal binding site [ion binding]; metal-binding site 521095002892 primosome assembly protein PriA; Validated; Region: PRK05580 521095002893 primosome assembly protein PriA; Validated; Region: PRK05580 521095002894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095002895 ATP binding site [chemical binding]; other site 521095002896 putative Mg++ binding site [ion binding]; other site 521095002897 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 521095002898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095002899 nucleotide binding region [chemical binding]; other site 521095002900 ATP-binding site [chemical binding]; other site 521095002901 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 521095002902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002903 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 521095002904 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 521095002905 Protein of unknown function (DUF328); Region: DUF328; cl01143 521095002906 OpgC protein; Region: OpgC_C; cl00792 521095002907 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 521095002908 Membrane protein of unknown function; Region: DUF360; cl00850 521095002909 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521095002910 dimerization domain swap beta strand [polypeptide binding]; other site 521095002911 regulatory protein interface [polypeptide binding]; other site 521095002912 active site 521095002913 regulatory phosphorylation site [posttranslational modification]; other site 521095002914 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521095002915 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 521095002916 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 521095002917 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 521095002918 CAAX protease self-immunity; Region: Abi; cl00558 521095002919 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 521095002920 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095002921 active site 521095002922 HIGH motif; other site 521095002923 nucleotide binding site [chemical binding]; other site 521095002924 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095002925 KMSKS motif; other site 521095002926 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095002927 tRNA binding surface [nucleotide binding]; other site 521095002928 anticodon binding site; other site 521095002929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095002930 Helix-turn-helix domains; Region: HTH; cl00088 521095002931 transcriptional regulator SlyA; Provisional; Region: PRK03573 521095002932 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095002933 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095002935 Walker A/P-loop; other site 521095002936 ATP binding site [chemical binding]; other site 521095002937 Q-loop/lid; other site 521095002938 ABC transporter signature motif; other site 521095002939 Walker B; other site 521095002940 D-loop; other site 521095002941 H-loop/switch region; other site 521095002942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002943 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095002944 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 521095002945 Walker A/P-loop; other site 521095002946 ATP binding site [chemical binding]; other site 521095002947 Q-loop/lid; other site 521095002948 ABC transporter signature motif; other site 521095002949 Walker B; other site 521095002950 D-loop; other site 521095002951 H-loop/switch region; other site 521095002952 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521095002953 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095002954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095002955 TPR motif; other site 521095002956 binding surface 521095002957 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521095002958 active site 521095002959 metal binding site [ion binding]; metal-binding site 521095002960 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095002961 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 521095002962 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 521095002963 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095002964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 521095002965 DNA-binding site [nucleotide binding]; DNA binding site 521095002966 RNA-binding motif; other site 521095002967 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095002968 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095002969 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 521095002970 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521095002971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095002972 Walker A motif; other site 521095002973 ATP binding site [chemical binding]; other site 521095002974 Walker B motif; other site 521095002975 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521095002976 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 521095002977 RuvA N terminal domain; Region: RuvA_N; pfam01330 521095002978 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 521095002979 active site 521095002980 putative DNA-binding cleft [nucleotide binding]; other site 521095002981 dimer interface [polypeptide binding]; other site 521095002982 Predicted amidohydrolase [General function prediction only]; Region: COG0388 521095002983 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 521095002984 active site 521095002985 catalytic triad [active] 521095002986 dimer interface [polypeptide binding]; other site 521095002987 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 521095002988 Ligand Binding Site [chemical binding]; other site 521095002989 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 521095002990 non-heme iron binding site [ion binding]; other site 521095002991 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 521095002992 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 521095002993 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 521095002994 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 521095002995 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521095002996 generic binding surface II; other site 521095002997 generic binding surface I; other site 521095002998 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 521095002999 trimer interface [polypeptide binding]; other site 521095003000 active site 521095003001 G bulge; other site 521095003002 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 521095003003 trimer interface [polypeptide binding]; other site 521095003004 active site 521095003005 G bulge; other site 521095003006 Uncharacterized conserved protein [Function unknown]; Region: COG1739 521095003007 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521095003008 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 521095003009 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 521095003010 HPr interaction site; other site 521095003011 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521095003012 active site 521095003013 phosphorylation site [posttranslational modification] 521095003014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095003015 S-adenosylmethionine binding site [chemical binding]; other site 521095003016 histone acetyltransferase, ELP3 family; Region: ELP3; TIGR01211 521095003017 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 521095003018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095003019 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 521095003020 catalytic residue [active] 521095003021 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521095003022 peroxiredoxin; Region: AhpC; TIGR03137 521095003023 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 521095003024 dimer interface [polypeptide binding]; other site 521095003025 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521095003026 catalytic triad [active] 521095003027 peroxidatic and resolving cysteines [active] 521095003028 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 521095003029 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 521095003030 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521095003031 Ligand Binding Site [chemical binding]; other site 521095003032 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521095003033 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 521095003034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095003035 catalytic residue [active] 521095003036 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 521095003037 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521095003038 anti sigma factor interaction site; other site 521095003039 regulatory phosphorylation site [posttranslational modification]; other site 521095003040 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521095003041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003042 ATP binding site [chemical binding]; other site 521095003043 Mg2+ binding site [ion binding]; other site 521095003044 G-X-G motif; other site 521095003045 PAS domain; Region: PAS_9; pfam13426 521095003046 GAF domain; Region: GAF_2; pfam13185 521095003047 GAF domain; Region: GAF; cl15785 521095003048 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 521095003049 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 521095003050 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003051 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 521095003052 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003053 Walker A/P-loop; other site 521095003054 ATP binding site [chemical binding]; other site 521095003055 Q-loop/lid; other site 521095003056 ABC transporter signature motif; other site 521095003057 Walker B; other site 521095003058 D-loop; other site 521095003059 H-loop/switch region; other site 521095003060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003061 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003062 Walker A/P-loop; other site 521095003063 ATP binding site [chemical binding]; other site 521095003064 Q-loop/lid; other site 521095003065 ABC transporter signature motif; other site 521095003066 Walker B; other site 521095003067 D-loop; other site 521095003068 H-loop/switch region; other site 521095003069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521095003071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003072 dimer interface [polypeptide binding]; other site 521095003073 conserved gate region; other site 521095003074 ABC-ATPase subunit interface; other site 521095003075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003077 dimer interface [polypeptide binding]; other site 521095003078 conserved gate region; other site 521095003079 putative PBP binding loops; other site 521095003080 ABC-ATPase subunit interface; other site 521095003081 Preprotein translocase SecG subunit; Region: SecG; cl09123 521095003082 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521095003083 substrate binding site [chemical binding]; other site 521095003084 dimer interface [polypeptide binding]; other site 521095003085 catalytic triad [active] 521095003086 Phosphoglycerate kinase; Region: PGK; pfam00162 521095003087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521095003088 substrate binding site [chemical binding]; other site 521095003089 hinge regions; other site 521095003090 ADP binding site [chemical binding]; other site 521095003091 catalytic site [active] 521095003092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003093 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 521095003094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 521095003095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 521095003096 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 521095003097 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 521095003098 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 521095003099 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 521095003100 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 521095003101 putative active site cavity [active] 521095003102 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521095003103 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 521095003104 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521095003105 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521095003106 active site 521095003107 inhibitor site; inhibition site 521095003108 dimer interface [polypeptide binding]; other site 521095003109 catalytic residue [active] 521095003110 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 521095003111 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 521095003112 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 521095003113 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003114 Walker A/P-loop; other site 521095003115 ATP binding site [chemical binding]; other site 521095003116 Q-loop/lid; other site 521095003117 ABC transporter signature motif; other site 521095003118 Walker B; other site 521095003119 D-loop; other site 521095003120 H-loop/switch region; other site 521095003121 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003122 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 521095003123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003124 dimer interface [polypeptide binding]; other site 521095003125 conserved gate region; other site 521095003126 putative PBP binding loops; other site 521095003127 ABC-ATPase subunit interface; other site 521095003128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521095003129 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003130 Walker A/P-loop; other site 521095003131 ATP binding site [chemical binding]; other site 521095003132 Q-loop/lid; other site 521095003133 ABC transporter signature motif; other site 521095003134 Walker B; other site 521095003135 D-loop; other site 521095003136 H-loop/switch region; other site 521095003137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003140 dimer interface [polypeptide binding]; other site 521095003141 conserved gate region; other site 521095003142 putative PBP binding loops; other site 521095003143 ABC-ATPase subunit interface; other site 521095003144 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003145 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003146 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 521095003147 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521095003148 GIY-YIG motif/motif A; other site 521095003149 active site 521095003150 catalytic site [active] 521095003151 putative DNA binding site [nucleotide binding]; other site 521095003152 metal binding site [ion binding]; metal-binding site 521095003153 UvrB/uvrC motif; Region: UVR; pfam02151 521095003154 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521095003155 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 521095003156 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 521095003157 putative deacylase active site [active] 521095003158 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521095003159 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 521095003160 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 521095003161 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 521095003162 Domain of unknown function (DUF386); Region: DUF386; cl01047 521095003163 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 521095003164 flavoprotein, HI0933 family; Region: TIGR00275 521095003165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003166 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 521095003167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003168 excinuclease ABC subunit B; Provisional; Region: PRK05298 521095003169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095003170 ATP binding site [chemical binding]; other site 521095003171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095003172 nucleotide binding region [chemical binding]; other site 521095003173 ATP-binding site [chemical binding]; other site 521095003174 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521095003175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095003176 TPR motif; other site 521095003177 binding surface 521095003178 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 521095003179 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521095003180 CoA-binding site [chemical binding]; other site 521095003181 ATP-binding [chemical binding]; other site 521095003182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095003183 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 521095003184 Walker A/P-loop; other site 521095003185 ATP binding site [chemical binding]; other site 521095003186 Q-loop/lid; other site 521095003187 ABC transporter signature motif; other site 521095003188 Walker B; other site 521095003189 D-loop; other site 521095003190 H-loop/switch region; other site 521095003191 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521095003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003193 dimer interface [polypeptide binding]; other site 521095003194 conserved gate region; other site 521095003195 putative PBP binding loops; other site 521095003196 ABC-ATPase subunit interface; other site 521095003197 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 521095003198 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521095003199 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521095003200 metal binding site [ion binding]; metal-binding site 521095003201 peptidase T; Region: peptidase-T; TIGR01882 521095003202 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521095003203 metal binding site [ion binding]; metal-binding site 521095003204 dimer interface [polypeptide binding]; other site 521095003205 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 521095003206 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 521095003207 catalytic triad [active] 521095003208 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003209 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003210 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 521095003211 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003212 Walker A/P-loop; other site 521095003213 ATP binding site [chemical binding]; other site 521095003214 Q-loop/lid; other site 521095003215 ABC transporter signature motif; other site 521095003216 Walker B; other site 521095003217 D-loop; other site 521095003218 H-loop/switch region; other site 521095003219 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003220 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521095003221 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 521095003222 Walker A/P-loop; other site 521095003223 ATP binding site [chemical binding]; other site 521095003224 Q-loop/lid; other site 521095003225 ABC transporter signature motif; other site 521095003226 Walker B; other site 521095003227 D-loop; other site 521095003228 H-loop/switch region; other site 521095003229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003230 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521095003231 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 521095003232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003233 dimer interface [polypeptide binding]; other site 521095003234 conserved gate region; other site 521095003235 putative PBP binding loops; other site 521095003236 ABC-ATPase subunit interface; other site 521095003237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003239 dimer interface [polypeptide binding]; other site 521095003240 conserved gate region; other site 521095003241 putative PBP binding loops; other site 521095003242 ABC-ATPase subunit interface; other site 521095003243 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003244 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003245 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 521095003246 Collagen binding domain; Region: Collagen_bind; pfam05737 521095003247 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095003248 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 521095003249 domain interaction interfaces; other site 521095003250 putative Ca2+ binding sites [ion binding]; other site 521095003251 putative ligand binding motif; other site 521095003252 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 521095003253 putative ligand binding motif; other site 521095003254 domain interaction interfaces; other site 521095003255 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521095003256 RNA binding site [nucleotide binding]; other site 521095003257 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521095003258 RNA binding site [nucleotide binding]; other site 521095003259 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 521095003260 RNA binding site [nucleotide binding]; other site 521095003261 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095003262 RNA binding site [nucleotide binding]; other site 521095003263 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095003264 metal-binding site [ion binding] 521095003265 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095003266 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 521095003267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521095003268 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095003269 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095003270 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 521095003271 catalytic residues [active] 521095003272 dimer interface [polypeptide binding]; other site 521095003273 Helix-turn-helix domains; Region: HTH; cl00088 521095003274 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521095003275 Cation efflux family; Region: Cation_efflux; cl00316 521095003276 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 521095003277 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 521095003278 G1 box; other site 521095003279 GTP/Mg2+ binding site [chemical binding]; other site 521095003280 Switch I region; other site 521095003281 G2 box; other site 521095003282 G3 box; other site 521095003283 Switch II region; other site 521095003284 G4 box; other site 521095003285 G5 box; other site 521095003286 Nucleoside recognition; Region: Gate; cl00486 521095003287 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 521095003288 Nucleoside recognition; Region: Gate; cl00486 521095003289 FeoA domain; Region: FeoA; cl00838 521095003290 FeoA domain; Region: FeoA; cl00838 521095003291 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 521095003292 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 521095003293 MatE; Region: MatE; cl10513 521095003294 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 521095003295 C-terminal domain interface [polypeptide binding]; other site 521095003296 GSH binding site (G-site) [chemical binding]; other site 521095003297 dimer interface [polypeptide binding]; other site 521095003298 Protein of unknown function (DUF523); Region: DUF523; cl00733 521095003299 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521095003300 trigger factor; Provisional; Region: tig; PRK01490 521095003301 LabA_like proteins; Region: LabA_like; cd06167 521095003302 putative metal binding site [ion binding]; other site 521095003303 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 521095003304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003305 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521095003306 NAD(P) binding pocket [chemical binding]; other site 521095003307 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 521095003308 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 521095003309 30S subunit binding site; other site 521095003310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 521095003311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095003312 substrate binding pocket [chemical binding]; other site 521095003313 membrane-bound complex binding site; other site 521095003314 hinge residues; other site 521095003315 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 521095003316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095003317 active site 521095003318 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 521095003319 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 521095003320 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 521095003321 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003322 Walker A/P-loop; other site 521095003323 ATP binding site [chemical binding]; other site 521095003324 Q-loop/lid; other site 521095003325 ABC transporter signature motif; other site 521095003326 Walker B; other site 521095003327 D-loop; other site 521095003328 H-loop/switch region; other site 521095003329 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003330 Walker A/P-loop; other site 521095003331 ATP binding site [chemical binding]; other site 521095003332 Q-loop/lid; other site 521095003333 ABC transporter signature motif; other site 521095003334 Walker B; other site 521095003335 D-loop; other site 521095003336 H-loop/switch region; other site 521095003337 PQQ-like domain; Region: PQQ_2; pfam13360 521095003338 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521095003339 Trp docking motif [polypeptide binding]; other site 521095003340 active site 521095003341 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 521095003342 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521095003343 trimer interface [polypeptide binding]; other site 521095003344 active site 521095003345 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 521095003346 NifU-like domain; Region: NifU; cl00484 521095003347 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 521095003348 Peptidase family U32; Region: Peptidase_U32; cl03113 521095003349 Collagenase; Region: DUF3656; pfam12392 521095003350 Peptidase family U32; Region: Peptidase_U32; cl03113 521095003351 Cupin domain; Region: Cupin_2; cl09118 521095003352 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 521095003353 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521095003354 Ligand binding site; other site 521095003355 Putative Catalytic site; other site 521095003356 DXD motif; other site 521095003357 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 521095003358 MatE; Region: MatE; cl10513 521095003359 LicD family; Region: LicD; cl01378 521095003360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095003361 active site 521095003362 EamA-like transporter family; Region: EamA; cl01037 521095003363 Helix-turn-helix domains; Region: HTH; cl00088 521095003364 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 521095003365 active site 521095003366 metal-binding site 521095003367 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 521095003368 active site 521095003369 ATP binding site [chemical binding]; other site 521095003370 substrate binding site [chemical binding]; other site 521095003371 dimer interface [polypeptide binding]; other site 521095003372 LicD family; Region: LicD; cl01378 521095003373 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 521095003374 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 521095003375 NAD binding site [chemical binding]; other site 521095003376 substrate binding site [chemical binding]; other site 521095003377 homodimer interface [polypeptide binding]; other site 521095003378 active site 521095003379 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 521095003380 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 521095003381 NADP binding site [chemical binding]; other site 521095003382 active site 521095003383 putative substrate binding site [chemical binding]; other site 521095003384 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 521095003385 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 521095003386 substrate binding site; other site 521095003387 tetramer interface; other site 521095003388 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521095003389 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521095003390 active site 521095003391 HIGH motif; other site 521095003392 dimer interface [polypeptide binding]; other site 521095003393 KMSKS motif; other site 521095003394 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521095003395 Transglycosylase; Region: Transgly; cl07896 521095003396 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 521095003397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095003398 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 521095003399 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 521095003400 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 521095003401 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521095003402 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521095003403 active site 521095003404 substrate binding site [chemical binding]; other site 521095003405 metal binding site [ion binding]; metal-binding site 521095003406 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 521095003407 THUMP domain; Region: THUMP; cl12076 521095003408 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 521095003409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095003410 S-adenosylmethionine binding site [chemical binding]; other site 521095003411 K+ potassium transporter; Region: K_trans; cl15781 521095003412 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095003413 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521095003414 active site 521095003415 motif I; other site 521095003416 motif II; other site 521095003417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095003418 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 521095003419 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 521095003420 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521095003421 active site 521095003422 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 521095003423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095003424 non-specific DNA binding site [nucleotide binding]; other site 521095003425 salt bridge; other site 521095003426 sequence-specific DNA binding site [nucleotide binding]; other site 521095003427 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 521095003428 TadE-like protein; Region: TadE; cl10688 521095003429 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 521095003430 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 521095003431 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521095003432 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 521095003433 ATP binding site [chemical binding]; other site 521095003434 Walker A motif; other site 521095003435 hexamer interface [polypeptide binding]; other site 521095003436 Walker B motif; other site 521095003437 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521095003438 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095003439 SAF domain; Region: SAF; cl00555 521095003440 Predicted GTPases [General function prediction only]; Region: COG1162 521095003441 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095003442 RNA binding site [nucleotide binding]; other site 521095003443 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521095003444 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521095003445 GTP/Mg2+ binding site [chemical binding]; other site 521095003446 G4 box; other site 521095003447 G5 box; other site 521095003448 G1 box; other site 521095003449 Switch I region; other site 521095003450 G2 box; other site 521095003451 G3 box; other site 521095003452 Switch II region; other site 521095003453 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 521095003454 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 521095003455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095003456 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521095003457 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095003458 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095003459 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 521095003460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003461 pyruvate kinase; Provisional; Region: PRK05826 521095003462 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 521095003463 domain interfaces; other site 521095003464 active site 521095003465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003466 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095003467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095003468 Walker A/P-loop; other site 521095003469 ATP binding site [chemical binding]; other site 521095003470 Q-loop/lid; other site 521095003471 ABC transporter signature motif; other site 521095003472 Walker B; other site 521095003473 D-loop; other site 521095003474 H-loop/switch region; other site 521095003475 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003476 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095003477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095003478 Walker A/P-loop; other site 521095003479 ATP binding site [chemical binding]; other site 521095003480 Q-loop/lid; other site 521095003481 ABC transporter signature motif; other site 521095003482 Walker B; other site 521095003483 D-loop; other site 521095003484 H-loop/switch region; other site 521095003485 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 521095003486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095003487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095003488 active site 521095003489 phosphorylation site [posttranslational modification] 521095003490 intermolecular recognition site; other site 521095003491 dimerization interface [polypeptide binding]; other site 521095003492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095003493 DNA binding site [nucleotide binding] 521095003494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095003495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095003496 dimer interface [polypeptide binding]; other site 521095003497 phosphorylation site [posttranslational modification] 521095003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003499 ATP binding site [chemical binding]; other site 521095003500 Mg2+ binding site [ion binding]; other site 521095003501 G-X-G motif; other site 521095003502 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 521095003503 homodimer interface [polypeptide binding]; other site 521095003504 putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510 521095003505 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 521095003506 active site 521095003507 homodimer interface [polypeptide binding]; other site 521095003508 catalytic site [active] 521095003509 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 521095003510 glycogen synthase; Provisional; Region: glgA; PRK00654 521095003511 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 521095003512 ADP-binding pocket [chemical binding]; other site 521095003513 homodimer interface [polypeptide binding]; other site 521095003514 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 521095003515 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521095003516 ligand binding site; other site 521095003517 oligomer interface; other site 521095003518 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521095003519 dimer interface [polypeptide binding]; other site 521095003520 N-terminal domain interface [polypeptide binding]; other site 521095003521 sulfate 1 binding site; other site 521095003522 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 521095003523 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521095003524 ligand binding site; other site 521095003525 oligomer interface; other site 521095003526 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521095003527 dimer interface [polypeptide binding]; other site 521095003528 N-terminal domain interface [polypeptide binding]; other site 521095003529 sulfate 1 binding site; other site 521095003530 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 521095003531 homodimer interface [polypeptide binding]; other site 521095003532 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 521095003533 active site pocket [active] 521095003534 glycogen branching enzyme; Provisional; Region: PRK12313 521095003535 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 521095003536 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 521095003537 active site 521095003538 catalytic site [active] 521095003539 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 521095003540 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 521095003541 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 521095003542 active site 521095003543 NAD binding site [chemical binding]; other site 521095003544 metal binding site [ion binding]; metal-binding site 521095003545 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 521095003546 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 521095003547 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 521095003548 putative tRNA-binding site [nucleotide binding]; other site 521095003549 B3/4 domain; Region: B3_4; cl11458 521095003550 tRNA synthetase B5 domain; Region: B5; cl08394 521095003551 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521095003552 dimer interface [polypeptide binding]; other site 521095003553 motif 1; other site 521095003554 motif 3; other site 521095003555 motif 2; other site 521095003556 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 521095003557 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 521095003558 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 521095003559 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521095003560 dimer interface [polypeptide binding]; other site 521095003561 motif 1; other site 521095003562 active site 521095003563 motif 2; other site 521095003564 motif 3; other site 521095003565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521095003566 ABC-ATPase subunit interface; other site 521095003567 dimer interface [polypeptide binding]; other site 521095003568 putative PBP binding regions; other site 521095003569 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521095003570 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 521095003571 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 521095003572 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 521095003573 metal binding site [ion binding]; metal-binding site 521095003574 Protein of unknown function (DUF421); Region: DUF421; cl00990 521095003575 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 521095003576 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 521095003577 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 521095003578 active site 521095003579 dimer interface [polypeptide binding]; other site 521095003580 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 521095003581 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521095003582 dimer interface [polypeptide binding]; other site 521095003583 active site 521095003584 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 521095003585 putative active site [active] 521095003586 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095003587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095003588 DNA-binding site [nucleotide binding]; DNA binding site 521095003589 UTRA domain; Region: UTRA; cl01230 521095003590 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 521095003591 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 521095003592 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 521095003593 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 521095003594 active site 521095003595 phosphorylation site [posttranslational modification] 521095003596 Preprotein translocase subunit; Region: YajC; cl00806 521095003597 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 521095003598 active pocket/dimerization site; other site 521095003599 active site 521095003600 phosphorylation site [posttranslational modification] 521095003601 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095003602 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095003603 putative substrate binding site [chemical binding]; other site 521095003604 putative ATP binding site [chemical binding]; other site 521095003605 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 521095003606 hypothetical protein; Provisional; Region: PRK08185 521095003607 intersubunit interface [polypeptide binding]; other site 521095003608 active site 521095003609 zinc binding site [ion binding]; other site 521095003610 Na+ binding site [ion binding]; other site 521095003611 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 521095003612 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 521095003613 homodimer interface [polypeptide binding]; other site 521095003614 substrate-cofactor binding pocket; other site 521095003615 catalytic residue [active] 521095003616 Protein of unknown function, DUF488; Region: DUF488; cl01246 521095003617 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 521095003618 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 521095003619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521095003620 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 521095003621 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 521095003622 HPr interaction site; other site 521095003623 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521095003624 active site 521095003625 phosphorylation site [posttranslational modification] 521095003626 FtsX-like permease family; Region: FtsX; cl15850 521095003627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095003628 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095003629 Walker A/P-loop; other site 521095003630 ATP binding site [chemical binding]; other site 521095003631 Q-loop/lid; other site 521095003632 ABC transporter signature motif; other site 521095003633 Walker B; other site 521095003634 D-loop; other site 521095003635 H-loop/switch region; other site 521095003636 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521095003637 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521095003638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095003639 Coenzyme A binding pocket [chemical binding]; other site 521095003640 sensory histidine kinase CreC; Provisional; Region: PRK11100 521095003641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003642 ATP binding site [chemical binding]; other site 521095003643 Mg2+ binding site [ion binding]; other site 521095003644 G-X-G motif; other site 521095003645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095003646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095003647 active site 521095003648 phosphorylation site [posttranslational modification] 521095003649 intermolecular recognition site; other site 521095003650 dimerization interface [polypeptide binding]; other site 521095003651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095003652 DNA binding site [nucleotide binding] 521095003653 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521095003654 active site 521095003655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095003656 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 521095003657 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521095003658 active site 521095003659 HIGH motif; other site 521095003660 KMSKS motif; other site 521095003661 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521095003662 tRNA binding surface [nucleotide binding]; other site 521095003663 anticodon binding site; other site 521095003664 Predicted methyltransferases [General function prediction only]; Region: COG0313 521095003665 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 521095003666 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 521095003667 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 521095003668 active site 521095003669 PSP1 C-terminal conserved region; Region: PSP1; cl00770 521095003670 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 521095003671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095003672 DNA polymerase III subunit delta'; Validated; Region: PRK05564 521095003673 thymidylate kinase; Validated; Region: tmk; PRK00698 521095003674 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521095003675 TMP-binding site; other site 521095003676 ATP-binding site [chemical binding]; other site 521095003677 DNA topoisomerase I; Validated; Region: PRK07219 521095003678 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 521095003679 active site 521095003680 putative interdomain interaction site [polypeptide binding]; other site 521095003681 putative metal-binding site [ion binding]; other site 521095003682 putative nucleotide binding site [chemical binding]; other site 521095003683 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521095003684 domain I; other site 521095003685 DNA binding groove [nucleotide binding] 521095003686 phosphate binding site [ion binding]; other site 521095003687 domain II; other site 521095003688 domain III; other site 521095003689 nucleotide binding site [chemical binding]; other site 521095003690 catalytic site [active] 521095003691 domain IV; other site 521095003692 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521095003693 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521095003694 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 521095003695 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 521095003696 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521095003697 anti sigma factor interaction site; other site 521095003698 regulatory phosphorylation site [posttranslational modification]; other site 521095003699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095003700 TPR motif; other site 521095003701 binding surface 521095003702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521095003703 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 521095003704 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095003705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095003706 homodimer interface [polypeptide binding]; other site 521095003707 catalytic residue [active] 521095003708 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 521095003709 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 521095003710 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 521095003711 RNA/DNA hybrid binding site [nucleotide binding]; other site 521095003712 active site 521095003713 DNA polymerase I; Provisional; Region: PRK05755 521095003714 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521095003715 active site 521095003716 metal binding site 1 [ion binding]; metal-binding site 521095003717 putative 5' ssDNA interaction site; other site 521095003718 metal binding site 3; metal-binding site 521095003719 metal binding site 2 [ion binding]; metal-binding site 521095003720 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521095003721 putative DNA binding site [nucleotide binding]; other site 521095003722 putative metal binding site [ion binding]; other site 521095003723 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 521095003724 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521095003725 active site 521095003726 DNA binding site [nucleotide binding] 521095003727 catalytic site [active] 521095003728 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 521095003729 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 521095003730 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521095003731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 521095003732 Predicted membrane protein [Function unknown]; Region: COG1971 521095003733 Domain of unknown function DUF; Region: DUF204; pfam02659 521095003734 Domain of unknown function DUF; Region: DUF204; pfam02659 521095003735 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 521095003736 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 521095003737 ArsC family; Region: ArsC; pfam03960 521095003738 putative ArsC-like catalytic residues; other site 521095003739 putative TRX-like catalytic residues [active] 521095003740 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521095003741 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 521095003742 nucleotide binding pocket [chemical binding]; other site 521095003743 K-X-D-G motif; other site 521095003744 catalytic site [active] 521095003745 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521095003746 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521095003747 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521095003748 Dimer interface [polypeptide binding]; other site 521095003749 BRCT sequence motif; other site 521095003750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095003751 active site 521095003752 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 521095003753 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 521095003754 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 521095003755 Ligand binding site; other site 521095003756 metal-binding site 521095003757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095003758 Plant ATP synthase F0; Region: YMF19; cl07975 521095003759 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 521095003760 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 521095003761 FtsX-like permease family; Region: FtsX; cl15850 521095003762 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095003763 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095003764 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 521095003765 Walker A/P-loop; other site 521095003766 ATP binding site [chemical binding]; other site 521095003767 Q-loop/lid; other site 521095003768 ABC transporter signature motif; other site 521095003769 Walker B; other site 521095003770 D-loop; other site 521095003771 H-loop/switch region; other site 521095003772 DNA polymerase IV; Reviewed; Region: PRK03103 521095003773 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 521095003774 active site 521095003775 DNA binding site [nucleotide binding] 521095003776 DJ-1 family protein; Region: not_thiJ; TIGR01383 521095003777 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 521095003778 conserved cys residue [active] 521095003779 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095003780 active site 521095003781 phosphorylation site [posttranslational modification] 521095003782 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 521095003783 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 521095003784 dimer interface [polypeptide binding]; other site 521095003785 active site 521095003786 metal binding site [ion binding]; metal-binding site 521095003787 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 521095003788 EamA-like transporter family; Region: EamA; cl01037 521095003789 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 521095003790 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 521095003791 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 521095003792 ATP cone domain; Region: ATP-cone; pfam03477 521095003793 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095003794 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521095003795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095003796 active site 521095003797 putative glycosyl transferase; Provisional; Region: PRK10073 521095003798 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095003799 active site 521095003800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095003801 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 521095003802 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521095003803 dimerization interface 3.5A [polypeptide binding]; other site 521095003804 active site 521095003805 Cobalt transport protein; Region: CbiQ; cl00463 521095003806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095003807 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003808 Walker A/P-loop; other site 521095003809 ATP binding site [chemical binding]; other site 521095003810 Q-loop/lid; other site 521095003811 ABC transporter signature motif; other site 521095003812 Walker B; other site 521095003813 D-loop; other site 521095003814 H-loop/switch region; other site 521095003815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095003816 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003817 Walker A/P-loop; other site 521095003818 ATP binding site [chemical binding]; other site 521095003819 Q-loop/lid; other site 521095003820 ABC transporter signature motif; other site 521095003821 Walker B; other site 521095003822 D-loop; other site 521095003823 H-loop/switch region; other site 521095003824 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 521095003825 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521095003826 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521095003827 alphaNTD homodimer interface [polypeptide binding]; other site 521095003828 alphaNTD - beta interaction site [polypeptide binding]; other site 521095003829 alphaNTD - beta' interaction site [polypeptide binding]; other site 521095003830 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 521095003831 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521095003832 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521095003833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095003834 RNA binding surface [nucleotide binding]; other site 521095003835 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 521095003836 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 521095003837 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 521095003838 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521095003839 rRNA binding site [nucleotide binding]; other site 521095003840 predicted 30S ribosome binding site; other site 521095003841 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521095003842 active site 521095003843 adenylate kinase; Reviewed; Region: adk; PRK00279 521095003844 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521095003845 AMP-binding site [chemical binding]; other site 521095003846 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521095003847 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521095003848 SecY translocase; Region: SecY; pfam00344 521095003849 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 521095003850 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 521095003851 23S rRNA binding site [nucleotide binding]; other site 521095003852 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521095003853 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521095003854 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521095003855 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521095003856 5S rRNA interface [nucleotide binding]; other site 521095003857 L27 interface [polypeptide binding]; other site 521095003858 23S rRNA interface [nucleotide binding]; other site 521095003859 L5 interface [polypeptide binding]; other site 521095003860 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521095003861 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521095003862 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521095003863 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 521095003864 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 521095003865 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521095003866 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521095003867 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521095003868 KOW motif; Region: KOW; cl00354 521095003869 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521095003870 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 521095003871 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 521095003872 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521095003873 23S rRNA interface [nucleotide binding]; other site 521095003874 putative translocon interaction site; other site 521095003875 signal recognition particle (SRP54) interaction site; other site 521095003876 L23 interface [polypeptide binding]; other site 521095003877 trigger factor interaction site; other site 521095003878 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521095003879 23S rRNA interface [nucleotide binding]; other site 521095003880 5S rRNA interface [nucleotide binding]; other site 521095003881 putative antibiotic binding site [chemical binding]; other site 521095003882 L25 interface [polypeptide binding]; other site 521095003883 L27 interface [polypeptide binding]; other site 521095003884 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521095003885 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521095003886 G-X-X-G motif; other site 521095003887 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521095003888 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521095003889 putative translocon binding site; other site 521095003890 protein-rRNA interface [nucleotide binding]; other site 521095003891 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 521095003892 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521095003893 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521095003894 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521095003895 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 521095003896 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 521095003897 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 521095003898 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521095003899 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 521095003900 active site 521095003901 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 521095003902 elongation factor G; Reviewed; Region: PRK00007 521095003903 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521095003904 G1 box; other site 521095003905 putative GEF interaction site [polypeptide binding]; other site 521095003906 GTP/Mg2+ binding site [chemical binding]; other site 521095003907 Switch I region; other site 521095003908 G2 box; other site 521095003909 G3 box; other site 521095003910 Switch II region; other site 521095003911 G4 box; other site 521095003912 G5 box; other site 521095003913 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521095003914 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521095003915 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521095003916 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 521095003917 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521095003918 S17 interaction site [polypeptide binding]; other site 521095003919 S8 interaction site; other site 521095003920 16S rRNA interaction site [nucleotide binding]; other site 521095003921 streptomycin interaction site [chemical binding]; other site 521095003922 23S rRNA interaction site [nucleotide binding]; other site 521095003923 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521095003924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 521095003925 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 521095003926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521095003927 dimerization interface [polypeptide binding]; other site 521095003928 putative DNA binding site [nucleotide binding]; other site 521095003929 putative Zn2+ binding site [ion binding]; other site 521095003930 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 521095003931 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521095003932 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 521095003933 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521095003934 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521095003935 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521095003936 cleft; other site 521095003937 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521095003938 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521095003939 DNA binding site [nucleotide binding] 521095003940 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521095003941 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 521095003942 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 521095003943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 521095003944 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 521095003945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521095003946 RPB1 interaction site [polypeptide binding]; other site 521095003947 RPB10 interaction site [polypeptide binding]; other site 521095003948 RPB11 interaction site [polypeptide binding]; other site 521095003949 RPB3 interaction site [polypeptide binding]; other site 521095003950 RPB12 interaction site [polypeptide binding]; other site 521095003951 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521095003952 peripheral dimer interface [polypeptide binding]; other site 521095003953 core dimer interface [polypeptide binding]; other site 521095003954 L10 interface [polypeptide binding]; other site 521095003955 L11 interface [polypeptide binding]; other site 521095003956 putative EF-Tu interaction site [polypeptide binding]; other site 521095003957 putative EF-G interaction site [polypeptide binding]; other site 521095003958 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521095003959 23S rRNA interface [nucleotide binding]; other site 521095003960 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521095003961 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521095003962 mRNA/rRNA interface [nucleotide binding]; other site 521095003963 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521095003964 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521095003965 23S rRNA interface [nucleotide binding]; other site 521095003966 L7/L12 interface [polypeptide binding]; other site 521095003967 putative thiostrepton binding site; other site 521095003968 L25 interface [polypeptide binding]; other site 521095003969 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 521095003970 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521095003971 putative homodimer interface [polypeptide binding]; other site 521095003972 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 521095003973 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 521095003974 elongation factor Tu; Reviewed; Region: PRK00049 521095003975 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521095003976 G1 box; other site 521095003977 GEF interaction site [polypeptide binding]; other site 521095003978 GTP/Mg2+ binding site [chemical binding]; other site 521095003979 Switch I region; other site 521095003980 G2 box; other site 521095003981 G3 box; other site 521095003982 Switch II region; other site 521095003983 G4 box; other site 521095003984 G5 box; other site 521095003985 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521095003986 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521095003987 Antibiotic Binding Site [chemical binding]; other site 521095003988 YacP-like NYN domain; Region: NYN_YacP; cl01491 521095003989 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521095003990 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 521095003991 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 521095003992 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 521095003993 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521095003994 active site 521095003995 HIGH motif; other site 521095003996 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521095003997 KMSKS motif; other site 521095003998 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095003999 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 521095004000 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 521095004001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095004002 Walker A/P-loop; other site 521095004003 ATP binding site [chemical binding]; other site 521095004004 Q-loop/lid; other site 521095004005 ABC transporter signature motif; other site 521095004006 Walker B; other site 521095004007 D-loop; other site 521095004008 H-loop/switch region; other site 521095004009 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 521095004010 homotrimer interaction site [polypeptide binding]; other site 521095004011 zinc binding site [ion binding]; other site 521095004012 CDP-binding sites; other site 521095004013 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 521095004014 substrate binding site; other site 521095004015 dimer interface; other site 521095004016 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 521095004017 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521095004018 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 521095004019 Clp protease ATP binding subunit; Region: clpC; CHL00095 521095004020 Clp amino terminal domain; Region: Clp_N; pfam02861 521095004021 Clp amino terminal domain; Region: Clp_N; pfam02861 521095004022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004023 Walker A motif; other site 521095004024 ATP binding site [chemical binding]; other site 521095004025 Walker B motif; other site 521095004026 arginine finger; other site 521095004027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004028 Walker A motif; other site 521095004029 ATP binding site [chemical binding]; other site 521095004030 Walker B motif; other site 521095004031 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 521095004032 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 521095004033 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 521095004034 dimer interface [polypeptide binding]; other site 521095004035 putative anticodon binding site; other site 521095004036 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 521095004037 motif 1; other site 521095004038 active site 521095004039 motif 2; other site 521095004040 motif 3; other site 521095004041 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 521095004042 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521095004043 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521095004044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 521095004045 malate dehydrogenase; Provisional; Region: PRK13529 521095004046 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521095004047 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 521095004048 NAD(P) binding site [chemical binding]; other site 521095004049 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 521095004050 active site 521095004051 tetramer interface [polypeptide binding]; other site 521095004052 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521095004053 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 521095004054 substrate binding site [chemical binding]; other site 521095004055 dimer interface [polypeptide binding]; other site 521095004056 ATP binding site [chemical binding]; other site 521095004057 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 521095004058 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 521095004059 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095004060 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521095004061 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 521095004062 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095004063 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521095004064 FMN binding site [chemical binding]; other site 521095004065 dimer interface [polypeptide binding]; other site 521095004066 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 521095004067 dimer interface [polypeptide binding]; other site 521095004068 FMN binding site [chemical binding]; other site 521095004069 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 521095004070 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 521095004071 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095004072 active site turn [active] 521095004073 phosphorylation site [posttranslational modification] 521095004074 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521095004075 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 521095004076 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 521095004077 putative active site [active] 521095004078 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 521095004079 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 521095004080 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 521095004081 putative active site [active] 521095004082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095004083 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095004084 GAF domain; Region: GAF; cl15785 521095004085 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 521095004086 dimer interface [polypeptide binding]; other site 521095004087 active site 521095004088 metal binding site [ion binding]; metal-binding site 521095004089 glutathione binding site [chemical binding]; other site 521095004090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521095004091 oligoendopeptidase F; Region: pepF; TIGR00181 521095004092 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 521095004093 active site 521095004094 Zn binding site [ion binding]; other site 521095004095 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 521095004096 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 521095004097 gating phenylalanine in ion channel; other site 521095004098 Restriction endonuclease; Region: Mrr_cat; cl00516 521095004099 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 521095004100 Uncharacterized conserved protein [Function unknown]; Region: COG4127 521095004101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004102 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521095004103 Walker A motif; other site 521095004104 ATP binding site [chemical binding]; other site 521095004105 Walker B motif; other site 521095004106 arginine finger; other site 521095004107 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521095004108 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095004109 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095004110 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095004111 putative phosphoketolase; Provisional; Region: PRK05261 521095004112 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 521095004113 TPP-binding site [chemical binding]; other site 521095004114 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 521095004115 XFP C-terminal domain; Region: XFP_C; pfam09363 521095004116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095004117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095004118 DNA binding site [nucleotide binding] 521095004119 domain linker motif; other site 521095004120 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521095004121 dimerization interface [polypeptide binding]; other site 521095004122 ligand binding site [chemical binding]; other site 521095004123 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 521095004124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521095004125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004126 sequence-specific DNA binding site [nucleotide binding]; other site 521095004127 salt bridge; other site 521095004128 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 521095004129 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 521095004130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095004131 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521095004132 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 521095004133 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 521095004134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095004135 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 521095004136 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521095004137 tetramer interface [polypeptide binding]; other site 521095004138 catalytic Zn binding site [ion binding]; other site 521095004139 NADP binding site [chemical binding]; other site 521095004140 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 521095004141 putative active site [active] 521095004142 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 521095004143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 521095004144 TM2 domain; Region: TM2; cl00984 521095004145 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095004146 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 521095004147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004148 dimer interface [polypeptide binding]; other site 521095004149 phosphorylation site [posttranslational modification] 521095004150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004151 ATP binding site [chemical binding]; other site 521095004152 Mg2+ binding site [ion binding]; other site 521095004153 G-X-G motif; other site 521095004154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095004155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004156 active site 521095004157 phosphorylation site [posttranslational modification] 521095004158 intermolecular recognition site; other site 521095004159 dimerization interface [polypeptide binding]; other site 521095004160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095004161 DNA binding site [nucleotide binding] 521095004162 transcriptional repressor DicA; Reviewed; Region: PRK09706 521095004163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004164 non-specific DNA binding site [nucleotide binding]; other site 521095004165 salt bridge; other site 521095004166 sequence-specific DNA binding site [nucleotide binding]; other site 521095004167 Isochorismatase family; Region: Isochorismatase; pfam00857 521095004168 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521095004169 catalytic triad [active] 521095004170 conserved cis-peptide bond; other site 521095004171 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 521095004172 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 521095004173 Fe-S cluster binding site [ion binding]; other site 521095004174 active site 521095004175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521095004176 alanine racemase; Reviewed; Region: alr; PRK00053 521095004177 active site 521095004178 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095004179 dimer interface [polypeptide binding]; other site 521095004180 substrate binding site [chemical binding]; other site 521095004181 catalytic residues [active] 521095004182 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 521095004183 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 521095004184 putative ATP binding site [chemical binding]; other site 521095004185 putative substrate binding site [chemical binding]; other site 521095004186 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 521095004187 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 521095004188 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 521095004189 active site 521095004190 substrate binding site [chemical binding]; other site 521095004191 metal binding site [ion binding]; metal-binding site 521095004192 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 521095004193 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521095004194 23S rRNA interface [nucleotide binding]; other site 521095004195 L3 interface [polypeptide binding]; other site 521095004196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 521095004197 Putative esterase; Region: Esterase; pfam00756 521095004198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 521095004199 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095004200 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095004201 putative substrate binding site [chemical binding]; other site 521095004202 putative ATP binding site [chemical binding]; other site 521095004203 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 521095004204 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 521095004205 active site 521095004206 nucleophile elbow; other site 521095004207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004208 non-specific DNA binding site [nucleotide binding]; other site 521095004209 salt bridge; other site 521095004210 sequence-specific DNA binding site [nucleotide binding]; other site 521095004211 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 521095004212 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521095004213 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 521095004214 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521095004215 active site 521095004216 P-loop; other site 521095004217 phosphorylation site [posttranslational modification] 521095004218 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 521095004219 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 521095004220 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 521095004221 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 521095004222 substrate binding [chemical binding]; other site 521095004223 active site 521095004224 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 521095004225 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 521095004226 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 521095004227 G5 domain; Region: G5; pfam07501 521095004228 LytTr DNA-binding domain; Region: LytTR; cl04498 521095004229 acid-resistance membrane protein; Provisional; Region: PRK10209 521095004230 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 521095004231 active site 521095004232 catalytic site [active] 521095004233 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 521095004234 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095004235 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521095004236 metal ion-dependent adhesion site (MIDAS); other site 521095004237 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 521095004238 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095004239 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 521095004240 Helix-turn-helix domains; Region: HTH; cl00088 521095004241 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 521095004242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521095004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095004244 S-adenosylmethionine binding site [chemical binding]; other site 521095004245 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 521095004246 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 521095004247 Rubredoxin; Region: Rubredoxin; pfam00301 521095004248 iron binding site [ion binding]; other site 521095004249 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521095004250 SmpB-tmRNA interface; other site 521095004251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521095004252 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 521095004253 RNB domain; Region: RNB; pfam00773 521095004254 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 521095004255 RNA binding site [nucleotide binding]; other site 521095004256 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521095004257 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095004258 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 521095004259 active site 521095004260 Spore germination protein; Region: Spore_permease; cl15802 521095004261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095004262 Helix-turn-helix domains; Region: HTH; cl00088 521095004263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095004264 dimerization interface [polypeptide binding]; other site 521095004265 FtsX-like permease family; Region: FtsX; cl15850 521095004266 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 521095004267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095004268 Walker A/P-loop; other site 521095004269 ATP binding site [chemical binding]; other site 521095004270 Q-loop/lid; other site 521095004271 ABC transporter signature motif; other site 521095004272 Walker B; other site 521095004273 D-loop; other site 521095004274 H-loop/switch region; other site 521095004275 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521095004276 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521095004277 active site 521095004278 intersubunit interface [polypeptide binding]; other site 521095004279 catalytic residue [active] 521095004280 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521095004281 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521095004282 inhibitor site; inhibition site 521095004283 active site 521095004284 dimer interface [polypeptide binding]; other site 521095004285 catalytic residue [active] 521095004286 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 521095004287 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 521095004288 putative active site [active] 521095004289 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 521095004290 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095004291 P-loop; other site 521095004292 active site 521095004293 phosphorylation site [posttranslational modification] 521095004294 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095004295 active site 521095004296 phosphorylation site [posttranslational modification] 521095004297 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521095004298 Helix-turn-helix domains; Region: HTH; cl00088 521095004299 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 521095004300 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521095004301 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521095004302 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521095004303 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 521095004304 peptide chain release factor 2; Validated; Region: prfB; PRK00578 521095004305 RF-1 domain; Region: RF-1; cl02875 521095004306 RF-1 domain; Region: RF-1; cl02875 521095004307 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 521095004308 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 521095004309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095004310 nucleotide binding region [chemical binding]; other site 521095004311 hypothetical protein; Provisional; Region: PRK02250 521095004312 SEC-C motif; Region: SEC-C; pfam02810 521095004313 Chromatin associated protein KTI12; Region: KTI12; pfam08433 521095004314 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 521095004315 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 521095004316 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521095004317 active site 521095004318 substrate binding site [chemical binding]; other site 521095004319 metal binding site [ion binding]; metal-binding site 521095004320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095004321 active site 521095004322 Helix-turn-helix domains; Region: HTH; cl00088 521095004323 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 521095004324 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521095004325 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 521095004326 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521095004327 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521095004328 hinge; other site 521095004329 active site 521095004330 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 521095004331 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 521095004332 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 521095004333 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 521095004334 alpha subunit interaction interface [polypeptide binding]; other site 521095004335 Walker A motif; other site 521095004336 ATP binding site [chemical binding]; other site 521095004337 Walker B motif; other site 521095004338 inhibitor binding site; inhibition site 521095004339 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521095004340 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 521095004341 ATP synthase; Region: ATP-synt; cl00365 521095004342 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 521095004343 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 521095004344 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 521095004345 beta subunit interaction interface [polypeptide binding]; other site 521095004346 Walker A motif; other site 521095004347 ATP binding site [chemical binding]; other site 521095004348 Walker B motif; other site 521095004349 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521095004350 Plant ATP synthase F0; Region: YMF19; cl07975 521095004351 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 521095004352 Plant ATP synthase F0; Region: YMF19; cl07975 521095004353 ATP synthase subunit C; Region: ATP-synt_C; cl00466 521095004354 ATP synthase A chain; Region: ATP-synt_A; cl00413 521095004355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095004356 active site 521095004357 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 521095004358 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 521095004359 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 521095004360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095004361 S-adenosylmethionine binding site [chemical binding]; other site 521095004362 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521095004363 RF-1 domain; Region: RF-1; cl02875 521095004364 RF-1 domain; Region: RF-1; cl02875 521095004365 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 521095004366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521095004367 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 521095004368 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 521095004369 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 521095004370 active site 521095004371 phosphorylation site [posttranslational modification] 521095004372 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 521095004373 active pocket/dimerization site; other site 521095004374 active site 521095004375 phosphorylation site [posttranslational modification] 521095004376 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 521095004377 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521095004378 active site 521095004379 dimer interface [polypeptide binding]; other site 521095004380 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521095004381 dimer interface [polypeptide binding]; other site 521095004382 active site 521095004383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521095004384 catalytic residues [active] 521095004385 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 521095004386 active site 521095004387 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521095004388 active site 521095004389 metal binding site [ion binding]; metal-binding site 521095004390 homotetramer interface [polypeptide binding]; other site 521095004391 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 521095004392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004393 active site 521095004394 phosphorylation site [posttranslational modification] 521095004395 intermolecular recognition site; other site 521095004396 dimerization interface [polypeptide binding]; other site 521095004397 LytTr DNA-binding domain; Region: LytTR; cl04498 521095004398 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 521095004399 Histidine kinase; Region: His_kinase; pfam06580 521095004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004401 ATP binding site [chemical binding]; other site 521095004402 Mg2+ binding site [ion binding]; other site 521095004403 G-X-G motif; other site 521095004404 QueT transporter; Region: QueT; cl01932 521095004405 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521095004406 conserved cys residue [active] 521095004407 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 521095004408 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 521095004409 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 521095004410 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 521095004411 dimer interface [polypeptide binding]; other site 521095004412 PYR/PP interface [polypeptide binding]; other site 521095004413 TPP binding site [chemical binding]; other site 521095004414 substrate binding site [chemical binding]; other site 521095004415 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 521095004416 Domain of unknown function; Region: EKR; cl11037 521095004417 4Fe-4S binding domain; Region: Fer4; cl02805 521095004418 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521095004419 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 521095004420 TPP-binding site [chemical binding]; other site 521095004421 dimer interface [polypeptide binding]; other site 521095004422 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 521095004423 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 521095004424 purine monophosphate binding site [chemical binding]; other site 521095004425 dimer interface [polypeptide binding]; other site 521095004426 putative catalytic residues [active] 521095004427 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521095004428 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521095004429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095004430 Coenzyme A binding pocket [chemical binding]; other site 521095004431 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095004432 active site 521095004433 HIGH motif; other site 521095004434 nucleotide binding site [chemical binding]; other site 521095004435 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095004436 active site 521095004437 KMSKS motif; other site 521095004438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004439 dimer interface [polypeptide binding]; other site 521095004440 phosphorylation site [posttranslational modification] 521095004441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004442 ATP binding site [chemical binding]; other site 521095004443 Mg2+ binding site [ion binding]; other site 521095004444 G-X-G motif; other site 521095004445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095004446 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 521095004447 DNA-binding site [nucleotide binding]; DNA binding site 521095004448 UTRA domain; Region: UTRA; cl01230 521095004449 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095004450 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 521095004451 active site turn [active] 521095004452 phosphorylation site [posttranslational modification] 521095004453 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 521095004454 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 521095004455 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 521095004456 Ca binding site [ion binding]; other site 521095004457 active site 521095004458 catalytic site [active] 521095004459 seryl-tRNA synthetase; Provisional; Region: PRK05431 521095004460 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521095004461 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 521095004462 dimer interface [polypeptide binding]; other site 521095004463 active site 521095004464 motif 1; other site 521095004465 motif 2; other site 521095004466 motif 3; other site 521095004467 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521095004468 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521095004469 active site 521095004470 ATP binding site [chemical binding]; other site 521095004471 substrate binding site [chemical binding]; other site 521095004472 activation loop (A-loop); other site 521095004473 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 521095004474 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095004475 phosphopeptide binding site; other site 521095004476 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095004477 phosphopeptide binding site; other site 521095004478 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 521095004479 active site 521095004480 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521095004481 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095004482 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 521095004483 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521095004484 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521095004485 active site 521095004486 ATP binding site [chemical binding]; other site 521095004487 substrate binding site [chemical binding]; other site 521095004488 activation loop (A-loop); other site 521095004489 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004490 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004491 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004492 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004493 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 521095004494 active site 521095004495 ATP binding site [chemical binding]; other site 521095004496 substrate binding site [chemical binding]; other site 521095004497 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 521095004498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521095004499 dimerization interface [polypeptide binding]; other site 521095004500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004501 dimer interface [polypeptide binding]; other site 521095004502 phosphorylation site [posttranslational modification] 521095004503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004504 ATP binding site [chemical binding]; other site 521095004505 Mg2+ binding site [ion binding]; other site 521095004506 G-X-G motif; other site 521095004507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095004508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004509 active site 521095004510 phosphorylation site [posttranslational modification] 521095004511 intermolecular recognition site; other site 521095004512 dimerization interface [polypeptide binding]; other site 521095004513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095004514 DNA binding site [nucleotide binding] 521095004515 adenylosuccinate lyase; Provisional; Region: PRK07492 521095004516 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 521095004517 tetramer interface [polypeptide binding]; other site 521095004518 active site 521095004519 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 521095004520 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 521095004521 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521095004522 metal binding site 2 [ion binding]; metal-binding site 521095004523 putative DNA binding helix; other site 521095004524 metal binding site 1 [ion binding]; metal-binding site 521095004525 dimer interface [polypeptide binding]; other site 521095004526 structural Zn2+ binding site [ion binding]; other site 521095004527 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 521095004528 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095004529 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 521095004530 WYL domain; Region: WYL; cl14852 521095004531 WYL domain; Region: WYL; cl14852 521095004532 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 521095004533 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521095004534 active site 521095004535 substrate binding site [chemical binding]; other site 521095004536 catalytic site [active] 521095004537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095004538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 521095004539 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 521095004540 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521095004541 ATP-grasp domain; Region: ATP-grasp_4; cl03087 521095004542 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 521095004543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095004544 FeS/SAM binding site; other site 521095004545 ParB-like partition proteins; Region: parB_part; TIGR00180 521095004546 ParB-like nuclease domain; Region: ParBc; cl02129 521095004547 KorB domain; Region: KorB; pfam08535 521095004548 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521095004549 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521095004550 P-loop; other site 521095004551 Magnesium ion binding site [ion binding]; other site 521095004552 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521095004553 Magnesium ion binding site [ion binding]; other site 521095004554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 521095004555 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521095004556 G-X-X-G motif; other site 521095004557 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 521095004558 RxxxH motif; other site 521095004559 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 521095004560 Haemolytic domain; Region: Haemolytic; cl00506 521095004561 Ribonuclease P; Region: Ribonuclease_P; cl00457 521095004562 Ribosomal protein L34; Region: Ribosomal_L34; cl00370